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BR112015027369A2 - composições e métodos para modular a expressão de hbv e ttr - Google Patents

composições e métodos para modular a expressão de hbv e ttr

Info

Publication number
BR112015027369A2
BR112015027369A2 BR112015027369A BR112015027369A BR112015027369A2 BR 112015027369 A2 BR112015027369 A2 BR 112015027369A2 BR 112015027369 A BR112015027369 A BR 112015027369A BR 112015027369 A BR112015027369 A BR 112015027369A BR 112015027369 A2 BR112015027369 A2 BR 112015027369A2
Authority
BR
Brazil
Prior art keywords
ttr
hbv
modulating
expression
compositions
Prior art date
Application number
BR112015027369A
Other languages
English (en)
Other versions
BR112015027369B1 (pt
BR112015027369A8 (pt
Inventor
E Swayze Eric
P Seth Punit
P Prakash Thazha
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51843959&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112015027369(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Priority to BR122018009831-7A priority Critical patent/BR122018009831B1/pt
Publication of BR112015027369A2 publication Critical patent/BR112015027369A2/pt
Publication of BR112015027369A8 publication Critical patent/BR112015027369A8/pt
Publication of BR112015027369B1 publication Critical patent/BR112015027369B1/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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Abstract

resumo patente de invenção: "composições e métodos para modular a expressão de hbv e ttr". a presente invenção refere-se aos compostos compreendendo um oligonucleotídeo modificado e um grupo de conjugado, em que o oligonucleotídeo modificado consiste em 8 a 80 nucleosídeos ligados e tem uma sequência de nucleobase pelo menos 85%, 90%, 95% ou 100% complementar a seq id no: 2 que codifica a transtirretina (ttr). em determinadas modalidades, os compostos oligoméricos estão conjugados à n-acetilgalactosamina.
BR112015027369-6A 2013-05-01 2014-05-01 compostos compreendendo um oligonucleotídeo modificado e um grupo de conjugado, composição compreendendo os referidos compostos e usos dos mesmos BR112015027369B1 (pt)

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CL2015003217A1 (es) 2016-07-08

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