EP2401367B1
(en)
|
2009-02-26 |
2016-11-30 |
Transposagen Biopharmaceuticals, Inc. |
Hyperactive piggybac transposases
|
US9445581B2
(en)
|
2012-03-28 |
2016-09-20 |
Kymab Limited |
Animal models and therapeutic molecules
|
ES2965212T3
(es)
|
2009-07-08 |
2024-04-11 |
Kymab Ltd |
Modelos de animales y moléculas terapéuticas
|
US9457077B2
(en)
|
2009-11-18 |
2016-10-04 |
Katherine Rose Kovarik |
Method and system for targeting the microbiome to promote health and treat allergic and inflammatory diseases
|
US9585920B2
(en)
|
2011-02-04 |
2017-03-07 |
Katherine Rose Kovarik |
Method and system for treating cancer cachexia
|
US10842834B2
(en)
|
2016-01-06 |
2020-11-24 |
Joseph E. Kovarik |
Method and system for reducing the likelihood of developing liver cancer in an individual diagnosed with non-alcoholic fatty liver disease
|
US11191665B2
(en)
|
2011-02-04 |
2021-12-07 |
Joseph E. Kovarik |
Method and system for reducing the likelihood of a porphyromonas gingivalis infection in a human being
|
US10548761B2
(en)
|
2011-02-04 |
2020-02-04 |
Joseph E. Kovarik |
Method and system for reducing the likelihood of colorectal cancer in a human being
|
US11844720B2
(en)
|
2011-02-04 |
2023-12-19 |
Seed Health, Inc. |
Method and system to reduce the likelihood of dental caries and halitosis
|
US10085938B2
(en)
|
2011-02-04 |
2018-10-02 |
Joseph E. Kovarik |
Method and system for preventing sore throat in humans
|
US10314865B2
(en)
|
2011-02-04 |
2019-06-11 |
Katherine Rose Kovarik |
Method and system for treating cancer and other age-related diseases by extending the healthspan of a human
|
US10111913B2
(en)
|
2011-02-04 |
2018-10-30 |
Joseph E. Kovarik |
Method of reducing the likelihood of skin cancer in an individual human being
|
US10687975B2
(en)
|
2011-02-04 |
2020-06-23 |
Joseph E. Kovarik |
Method and system to facilitate the growth of desired bacteria in a human's mouth
|
US10940169B2
(en)
|
2015-11-30 |
2021-03-09 |
Joseph E. Kovarik |
Method for reducing the likelihood of developing cancer in an individual human being
|
US10245288B2
(en)
|
2011-02-04 |
2019-04-02 |
Joseph E. Kovarik |
Method and system for reducing the likelihood of developing NASH in an individual diagnosed with non-alcoholic fatty liver disease
|
US11357722B2
(en)
|
2011-02-04 |
2022-06-14 |
Seed Health, Inc. |
Method and system for preventing sore throat in humans
|
US11419903B2
(en)
|
2015-11-30 |
2022-08-23 |
Seed Health, Inc. |
Method and system for reducing the likelihood of osteoporosis
|
US10010568B2
(en)
|
2011-02-04 |
2018-07-03 |
Katherine Rose Kovarik |
Method and system for reducing the likelihood of a spirochetes infection in a human being
|
US10086018B2
(en)
|
2011-02-04 |
2018-10-02 |
Joseph E. Kovarik |
Method and system for reducing the likelihood of colorectal cancer in a human being
|
US11998479B2
(en)
|
2011-02-04 |
2024-06-04 |
Seed Health, Inc. |
Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure
|
US11273187B2
(en)
|
2015-11-30 |
2022-03-15 |
Joseph E. Kovarik |
Method and system for reducing the likelihood of developing depression in an individual
|
US10583033B2
(en)
|
2011-02-04 |
2020-03-10 |
Katherine Rose Kovarik |
Method and system for reducing the likelihood of a porphyromonas gingivalis infection in a human being
|
US9987224B2
(en)
|
2011-02-04 |
2018-06-05 |
Joseph E. Kovarik |
Method and system for preventing migraine headaches, cluster headaches and dizziness
|
US11951140B2
(en)
|
2011-02-04 |
2024-04-09 |
Seed Health, Inc. |
Modulation of an individual's gut microbiome to address osteoporosis and bone disease
|
US10835560B2
(en)
|
2013-12-20 |
2020-11-17 |
Joseph E. Kovarik |
Reducing the likelihood of skin cancer in an individual human being
|
US11951139B2
(en)
|
2015-11-30 |
2024-04-09 |
Seed Health, Inc. |
Method and system for reducing the likelihood of osteoporosis
|
US9730967B2
(en)
|
2011-02-04 |
2017-08-15 |
Katherine Rose Kovarik |
Method and system for treating cancer cachexia
|
US11523934B2
(en)
|
2011-02-04 |
2022-12-13 |
Seed Health, Inc. |
Method and system to facilitate the growth of desired bacteria in a human's mouth
|
US10512661B2
(en)
|
2011-02-04 |
2019-12-24 |
Joseph E. Kovarik |
Method and system for reducing the likelihood of developing liver cancer in an individual diagnosed with non-alcoholic fatty liver disease
|
CN106434665B
(zh)
|
2011-06-30 |
2021-06-08 |
箭头药业股份有限公司 |
用于抑制乙型肝炎病毒的基因表达的组合物和方法
|
WO2013066438A2
(en)
|
2011-07-22 |
2013-05-10 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
CN107056936B
(zh)
|
2011-09-19 |
2021-09-03 |
科马布有限公司 |
免疫球蛋白基因多样性的操纵及多抗体治疗剂
|
EP2761008A1
(en)
|
2011-09-26 |
2014-08-06 |
Kymab Limited |
Chimaeric surrogate light chains (slc) comprising human vpreb
|
US9253965B2
(en)
|
2012-03-28 |
2016-02-09 |
Kymab Limited |
Animal models and therapeutic molecules
|
US10465042B2
(en)
|
2011-12-02 |
2019-11-05 |
Yale University |
Poly(amine-co-ester) nanoparticles and methods of use thereof
|
RU2663354C2
(ru)
|
2011-12-16 |
2018-08-03 |
Таргитджин Байотекнолоджиз Лтд |
Композиции и способы для модификации заданной последовательности нуклеиновой кислоты-мишени
|
WO2014163886A1
(en)
|
2013-03-12 |
2014-10-09 |
President And Fellows Of Harvard College |
Method of generating a three-dimensional nucleic acid containing matrix
|
ES2991004T3
(es)
|
2011-12-22 |
2024-12-02 |
Harvard College |
Métodos para la detección de analitos
|
GB201122458D0
(en)
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
US9637739B2
(en)
*
|
2012-03-20 |
2017-05-02 |
Vilnius University |
RNA-directed DNA cleavage by the Cas9-crRNA complex
|
GB2502127A
(en)
|
2012-05-17 |
2013-11-20 |
Kymab Ltd |
Multivalent antibodies and in vivo methods for their production
|
US10251377B2
(en)
|
2012-03-28 |
2019-04-09 |
Kymab Limited |
Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
|
EP2847335B1
(en)
|
2012-04-25 |
2018-06-27 |
Regeneron Pharmaceuticals, Inc. |
Nuclease-mediated targeting with large targeting vectors
|
EP3597741A1
(en)
|
2012-04-27 |
2020-01-22 |
Duke University |
Genetic correction of mutated genes
|
RS56119B1
(sr)
|
2012-05-25 |
2017-10-31 |
Univ California |
Postupci i sastavi za rnk-usmerenu modifikaciju ciljane dnk i za rnk-usmerenu modulaciju transkripcije
|
WO2013177560A1
(en)
|
2012-05-25 |
2013-11-28 |
The Regents Of The University Of California |
Microfluidic systems for particle trapping and separation
|
KR20150023670A
(ko)
*
|
2012-06-12 |
2015-03-05 |
제넨테크, 인크. |
조건적 녹아웃 대립유전자의 생성 방법 및 이를 위한 조성물
|
EP2861737B1
(en)
|
2012-06-19 |
2019-04-17 |
Regents Of The University Of Minnesota |
Gene targeting in plants using dna viruses
|
EP3808844A1
(en)
*
|
2012-07-25 |
2021-04-21 |
The Broad Institute, Inc. |
Inducible dna binding proteins and genome perturbation tools and applications thereof
|
AU2013335451C1
(en)
|
2012-10-23 |
2024-07-04 |
Toolgen Incorporated |
Composition for cleaving a target DNA comprising a guide RNA specific for the target DNA and Cas protein-encoding nucleic acid or Cas protein, and use thereof
|
KR102575769B1
(ko)
*
|
2012-10-23 |
2023-09-08 |
주식회사 툴젠 |
표적 DNA에 특이적인 가이드 RNA 및 Cas 단백질을 암호화하는 핵산 또는 Cas 단백질을 포함하는, 표적 DNA를 절단하기 위한 조성물 및 이의 용도
|
EP2920319B1
(en)
|
2012-11-16 |
2020-02-19 |
Poseida Therapeutics, Inc. |
Site-specific enzymes and methods of use
|
KR102240555B1
(ko)
|
2012-11-27 |
2021-04-16 |
칠드런'즈 메디컬 센터 코포레이션 |
태아 헤모글로빈 재유도를 위한 bcl11a 원위 조절 요소의 표적화
|
KR102243092B1
(ko)
*
|
2012-12-06 |
2021-04-22 |
시그마-알드리치 컴퍼니., 엘엘씨 |
Crispr-기초된 유전체 변형과 조절
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
PL2931898T3
(pl)
|
2012-12-12 |
2016-09-30 |
Le Cong |
Projektowanie i optymalizacja systemów, sposoby i kompozycje do manipulacji sekwencją z domenami funkcjonalnymi
|
US20140310830A1
(en)
|
2012-12-12 |
2014-10-16 |
Feng Zhang |
CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes
|
PT2771468E
(pt)
*
|
2012-12-12 |
2015-06-02 |
Harvard College |
Engenharia de sistemas, métodos e composições-guia otimizadas para manipulação de sequências
|
ES2883590T3
(es)
|
2012-12-12 |
2021-12-09 |
Broad Inst Inc |
Suministro, modificación y optimización de sistemas, métodos y composiciones para la manipulación de secuencias y aplicaciones terapéuticas
|
WO2014093718A1
(en)
*
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Methods, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
EP2931899A1
(en)
*
|
2012-12-12 |
2015-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
WO2014093709A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
IL300461A
(en)
|
2012-12-12 |
2023-04-01 |
Harvard College |
Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation
|
US20140189896A1
(en)
|
2012-12-12 |
2014-07-03 |
Feng Zhang |
Crispr-cas component systems, methods and compositions for sequence manipulation
|
DK2931891T3
(da)
|
2012-12-17 |
2019-08-19 |
Harvard College |
Rna-styret modificering af menneskelige genomer
|
CN104995302B
(zh)
|
2013-01-16 |
2021-08-31 |
爱默蕾大学 |
Cas9-核酸复合物及其相关用途
|
US11135273B2
(en)
|
2013-02-07 |
2021-10-05 |
The Rockefeller University |
Sequence specific antimicrobials
|
WO2014124226A1
(en)
|
2013-02-07 |
2014-08-14 |
The Rockefeller University |
Sequence specific antimicrobials
|
CN103981147B
(zh)
|
2013-02-08 |
2017-11-10 |
中国科学院上海生命科学研究院 |
一种新的制备肝实质细胞的方法
|
DK2963113T3
(da)
*
|
2013-02-14 |
2020-02-17 |
Univ Osaka |
Fremgangsmåde til isolering af specifik genomregion under anvendelse af molekyle, der binder specifikt til endogen dna-sekvens
|
CN109913495B
(zh)
|
2013-02-20 |
2022-11-25 |
瑞泽恩制药公司 |
大鼠的遗传修饰
|
WO2014131833A1
(en)
*
|
2013-02-27 |
2014-09-04 |
Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) |
Gene editing in the oocyte by cas9 nucleases
|
CA2905432C
(en)
|
2013-03-14 |
2021-09-14 |
Caribou Biosciences, Inc. |
Compositions and methods of nucleic acid-targeting nucleic acids
|
US9234213B2
(en)
*
|
2013-03-15 |
2016-01-12 |
System Biosciences, Llc |
Compositions and methods directed to CRISPR/Cas genomic engineering systems
|
US10760064B2
(en)
*
|
2013-03-15 |
2020-09-01 |
The General Hospital Corporation |
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
US9957515B2
(en)
|
2013-03-15 |
2018-05-01 |
Cibus Us Llc |
Methods and compositions for targeted gene modification
|
US20140273230A1
(en)
*
|
2013-03-15 |
2014-09-18 |
Sigma-Aldrich Co., Llc |
Crispr-based genome modification and regulation
|
KR102339732B1
(ko)
*
|
2013-03-15 |
2021-12-15 |
시버스 유에스 엘엘씨 |
올리고뉴클레오타이드 매개 유전자 보수를 사용한 표적화된 유전자 변형의 효율을 증가시키기 위한 방법 및 조성물
|
AU2014233465A1
(en)
|
2013-03-15 |
2015-09-03 |
Cibus Europe B.V. |
Targeted gene modification using oligonucleotide-mediated gene repair
|
US20140349400A1
(en)
*
|
2013-03-15 |
2014-11-27 |
Massachusetts Institute Of Technology |
Programmable Modification of DNA
|
WO2014144155A1
(en)
*
|
2013-03-15 |
2014-09-18 |
Regents Of The University Of Minnesota |
Engineering plant genomes using crispr/cas systems
|
KR102210319B1
(ko)
*
|
2013-03-15 |
2021-02-01 |
더 제너럴 하스피탈 코포레이션 |
특정 게놈 좌위에 대한 유전적 및 후성적 조절 단백질의 rna-안내 표적화
|
US9788534B2
(en)
|
2013-03-18 |
2017-10-17 |
Kymab Limited |
Animal models and therapeutic molecules
|
US9828582B2
(en)
|
2013-03-19 |
2017-11-28 |
Duke University |
Compositions and methods for the induction and tuning of gene expression
|
DK3456831T3
(da)
|
2013-04-16 |
2021-09-06 |
Regeneron Pharma |
Målrettet modifikation af rottegenom
|
US20160186208A1
(en)
*
|
2013-04-16 |
2016-06-30 |
Whitehead Institute For Biomedical Research |
Methods of Mutating, Modifying or Modulating Nucleic Acid in a Cell or Nonhuman Mammal
|
US9783618B2
(en)
|
2013-05-01 |
2017-10-10 |
Kymab Limited |
Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics
|
US11707056B2
(en)
|
2013-05-02 |
2023-07-25 |
Kymab Limited |
Animals, repertoires and methods
|
US9783593B2
(en)
|
2013-05-02 |
2017-10-10 |
Kymab Limited |
Antibodies, variable domains and chains tailored for human use
|
US10604771B2
(en)
|
2013-05-10 |
2020-03-31 |
Sangamo Therapeutics, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering
|
WO2014186435A2
(en)
|
2013-05-14 |
2014-11-20 |
University Of Georgia Research Foundation, Inc. |
Compositions and methods for reducing neointima formation
|
WO2014186585A2
(en)
|
2013-05-15 |
2014-11-20 |
Sangamo Biosciences, Inc. |
Methods and compositions for treatment of a genetic condition
|
WO2014186686A2
(en)
*
|
2013-05-17 |
2014-11-20 |
Two Blades Foundation |
Targeted mutagenesis and genome engineering in plants using rna-guided cas nucleases
|
DK3004349T3
(en)
*
|
2013-05-29 |
2018-06-06 |
Cellectis Sa |
A method for producing precise DNA cleavage using CAS9 nickase activity
|
AU2014273085B2
(en)
*
|
2013-05-29 |
2020-10-22 |
Cellectis |
New compact scaffold of Cas9 in the type II CRISPR system
|
US11414695B2
(en)
|
2013-05-29 |
2022-08-16 |
Agilent Technologies, Inc. |
Nucleic acid enrichment using Cas9
|
MX2015016798A
(es)
*
|
2013-06-04 |
2016-10-26 |
Harvard College |
Regulacion transcripcional guiada por acido ribonucleico.
|
US20140356956A1
(en)
*
|
2013-06-04 |
2014-12-04 |
President And Fellows Of Harvard College |
RNA-Guided Transcriptional Regulation
|
US9982277B2
(en)
|
2013-06-11 |
2018-05-29 |
The Regents Of The University Of California |
Methods and compositions for target DNA modification
|
EP3008186B1
(en)
|
2013-06-14 |
2018-11-28 |
Cellectis |
Methods for non-transgenic genome editing in plants
|
KR20160030187A
(ko)
*
|
2013-06-17 |
2016-03-16 |
더 브로드 인스티튜트, 인코퍼레이티드 |
간의 표적화 및 치료를 위한 CRISPRCas 시스템, 벡터 및 조성물의 전달 및 용도
|
CA2915834A1
(en)
|
2013-06-17 |
2014-12-24 |
Massachusetts Institute Of Technology |
Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
|
AU2014281030B2
(en)
*
|
2013-06-17 |
2020-07-09 |
Massachusetts Institute Of Technology |
Delivery, engineering and optimization of systems, methods and compositions for targeting and modeling diseases and disorders of post mitotic cells
|
KR20160034901A
(ko)
|
2013-06-17 |
2016-03-30 |
더 브로드 인스티튜트, 인코퍼레이티드 |
서열 조작에 최적화된 crispr-cas 이중 닉카아제 시스템, 방법 및 조성물
|
AU2014281031B2
(en)
*
|
2013-06-17 |
2020-05-21 |
Massachusetts Institute Of Technology |
Delivery, use and therapeutic applications of the CRISPR-Cas systems and compositions for targeting disorders and diseases using viral components
|
EP3011033B1
(en)
|
2013-06-17 |
2020-02-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
US10011850B2
(en)
|
2013-06-21 |
2018-07-03 |
The General Hospital Corporation |
Using RNA-guided FokI Nucleases (RFNs) to increase specificity for RNA-Guided Genome Editing
|
KR20220025922A
(ko)
|
2013-07-09 |
2022-03-03 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
멀티플렉스 rna-가이드된 게놈 조작
|
KR102481330B1
(ko)
|
2013-07-10 |
2022-12-23 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
Rna-가이드된 유전자 조절 및 편집을 위한 직교 cas9 단백질
|
US9663782B2
(en)
*
|
2013-07-19 |
2017-05-30 |
Larix Bioscience Llc |
Methods and compositions for producing double allele knock outs
|
US10563225B2
(en)
*
|
2013-07-26 |
2020-02-18 |
President And Fellows Of Harvard College |
Genome engineering
|
US10421957B2
(en)
|
2013-07-29 |
2019-09-24 |
Agilent Technologies, Inc. |
DNA assembly using an RNA-programmable nickase
|
ES2915377T3
(es)
|
2013-08-02 |
2022-06-22 |
Enevolv Inc |
Procedimientos y células huésped para ingeniería genómica, de vías y biomolécular
|
US20150044772A1
(en)
*
|
2013-08-09 |
2015-02-12 |
Sage Labs, Inc. |
Crispr/cas system-based novel fusion protein and its applications in genome editing
|
US20150044192A1
(en)
|
2013-08-09 |
2015-02-12 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a cas9 nuclease
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
EP3473720A1
(en)
|
2013-08-22 |
2019-04-24 |
Pioneer Hi-Bred International, Inc. |
Genome modification using guide polynucleotide/cas endonuclease systems and methods of use
|
EP4074330A1
(en)
*
|
2013-09-05 |
2022-10-19 |
Massachusetts Institute of Technology |
Tuning microbial populations with programmable nucleases
|
US9737604B2
(en)
|
2013-09-06 |
2017-08-22 |
President And Fellows Of Harvard College |
Use of cationic lipids to deliver CAS9
|
US9228207B2
(en)
|
2013-09-06 |
2016-01-05 |
President And Fellows Of Harvard College |
Switchable gRNAs comprising aptamers
|
US9388430B2
(en)
|
2013-09-06 |
2016-07-12 |
President And Fellows Of Harvard College |
Cas9-recombinase fusion proteins and uses thereof
|
CA2924069C
(en)
|
2013-09-11 |
2021-11-02 |
Arsia Therapeutics, Inc. |
Liquid protein formulations containing ionic liquids
|
WO2015040402A1
(en)
*
|
2013-09-18 |
2015-03-26 |
Kymab Limited |
Methods. cells & organisms
|
SG10201802295XA
(en)
|
2013-10-01 |
2018-04-27 |
Kymab Ltd |
Animal Models and Therapeutic Molecules
|
WO2015065964A1
(en)
|
2013-10-28 |
2015-05-07 |
The Broad Institute Inc. |
Functional genomics using crispr-cas systems, compositions, methods, screens and applications thereof
|
US10584358B2
(en)
|
2013-10-30 |
2020-03-10 |
North Carolina State University |
Compositions and methods related to a type-II CRISPR-Cas system in Lactobacillus buchneri
|
JP6560205B2
(ja)
*
|
2013-11-04 |
2019-08-14 |
ダウ アグロサイエンシィズ エルエルシー |
最適なダイズ遺伝子座
|
WO2015069682A2
(en)
*
|
2013-11-05 |
2015-05-14 |
President And Fellows Of Harvard College |
Precise microbiota engineering at the cellular level
|
EP3363903B1
(en)
|
2013-11-07 |
2024-01-03 |
Editas Medicine, Inc. |
Crispr-related methods and compositions with governing grnas
|
US11326209B2
(en)
*
|
2013-11-07 |
2022-05-10 |
Massachusetts Institute Of Technology |
Cell-based genomic recorded accumulative memory
|
EP3071695A2
(en)
*
|
2013-11-18 |
2016-09-28 |
Crispr Therapeutics AG |
Crispr-cas system materials and methods
|
US10787684B2
(en)
*
|
2013-11-19 |
2020-09-29 |
President And Fellows Of Harvard College |
Large gene excision and insertion
|
US9074199B1
(en)
|
2013-11-19 |
2015-07-07 |
President And Fellows Of Harvard College |
Mutant Cas9 proteins
|
PL3080279T3
(pl)
|
2013-12-11 |
2019-03-29 |
Regeneron Pharmaceuticals, Inc. |
Sposoby i kompozycje do celowanej modyfikacji genomu
|
AU2014360811B2
(en)
|
2013-12-11 |
2017-05-18 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for the targeted modification of a genome
|
WO2015089364A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crystal structure of a crispr-cas system, and uses thereof
|
CN111269902A
(zh)
*
|
2013-12-12 |
2020-06-12 |
布罗德研究所有限公司 |
Crispr-cas系统和组合物的递送及用途
|
CA2932472A1
(en)
|
2013-12-12 |
2015-06-18 |
Massachusetts Institute Of Technology |
Compositions and methods of use of crispr-cas systems in nucleotide repeat disorders
|
EP3080271B1
(en)
|
2013-12-12 |
2020-02-12 |
The Broad Institute, Inc. |
Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems
|
WO2015089277A1
(en)
*
|
2013-12-12 |
2015-06-18 |
The Regents Of The University Of California |
Methods and compositions for modifying a single stranded target nucleic acid
|
JP2017503485A
(ja)
|
2013-12-12 |
2017-02-02 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
遺伝子産物の発現、構造情報、及び誘導性モジュラーcas酵素を変更するためのcrispr−cas系並びに方法
|
US9840699B2
(en)
*
|
2013-12-12 |
2017-12-12 |
President And Fellows Of Harvard College |
Methods for nucleic acid editing
|
CN106061510B
(zh)
|
2013-12-12 |
2020-02-14 |
布罗德研究所有限公司 |
用于基因组编辑的crispr-cas系统和组合物的递送、用途和治疗应用
|
KR20160089526A
(ko)
*
|
2013-12-12 |
2016-07-27 |
더 브로드 인스티튜트, 인코퍼레이티드 |
입자 전달 성분을 이용한 표적 장애 및 질병에 대한 crispr-cas 시스템 및 조성물의 전달, 이용 및 치료 적용
|
US20160304893A1
(en)
*
|
2013-12-13 |
2016-10-20 |
Cellectis |
Cas9 nuclease platform for microalgae genome engineering
|
CN106030310B
(zh)
|
2013-12-13 |
2019-01-04 |
通用医疗公司 |
可溶性高分子量(hmw)tau种类及其应用
|
US20150191744A1
(en)
*
|
2013-12-17 |
2015-07-09 |
University Of Massachusetts |
Cas9 effector-mediated regulation of transcription, differentiation and gene editing/labeling
|
PT3083958T
(pt)
|
2013-12-19 |
2019-06-27 |
Amyris Inc |
Métodos de integração genómica
|
TWI672379B
(zh)
|
2013-12-19 |
2019-09-21 |
瑞士商諾華公司 |
人類間皮素嵌合性抗原受體及其用途
|
US11642382B2
(en)
|
2013-12-20 |
2023-05-09 |
Seed Health, Inc. |
Method for treating an individual suffering from bladder cancer
|
US11213552B2
(en)
|
2015-11-30 |
2022-01-04 |
Joseph E. Kovarik |
Method for treating an individual suffering from a chronic infectious disease and cancer
|
US11833177B2
(en)
|
2013-12-20 |
2023-12-05 |
Seed Health, Inc. |
Probiotic to enhance an individual's skin microbiome
|
EP3083671B1
(en)
|
2013-12-20 |
2020-09-30 |
Fred Hutchinson Cancer Research Center |
Tagged chimeric effector molecules and receptors thereof
|
US11998574B2
(en)
|
2013-12-20 |
2024-06-04 |
Seed Health, Inc. |
Method and system for modulating an individual's skin microbiome
|
US11969445B2
(en)
|
2013-12-20 |
2024-04-30 |
Seed Health, Inc. |
Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH
|
US11026982B2
(en)
|
2015-11-30 |
2021-06-08 |
Joseph E. Kovarik |
Method for reducing the likelihood of developing bladder or colorectal cancer in an individual human being
|
US11826388B2
(en)
|
2013-12-20 |
2023-11-28 |
Seed Health, Inc. |
Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation
|
US12005085B2
(en)
|
2013-12-20 |
2024-06-11 |
Seed Health, Inc. |
Probiotic method and composition for maintaining a healthy vaginal microbiome
|
US11980643B2
(en)
|
2013-12-20 |
2024-05-14 |
Seed Health, Inc. |
Method and system to modify an individual's gut-brain axis to provide neurocognitive protection
|
WO2015090229A1
(en)
|
2013-12-20 |
2015-06-25 |
Novartis Ag |
Regulatable chimeric antigen receptor
|
US11839632B2
(en)
|
2013-12-20 |
2023-12-12 |
Seed Health, Inc. |
Topical application of CRISPR-modified bacteria to treat acne vulgaris
|
US11529379B2
(en)
|
2013-12-20 |
2022-12-20 |
Seed Health, Inc. |
Method and system for reducing the likelihood of developing colorectal cancer in an individual human being
|
US11672835B2
(en)
|
2013-12-20 |
2023-06-13 |
Seed Health, Inc. |
Method for treating individuals having cancer and who are receiving cancer immunotherapy
|
JP6721508B2
(ja)
*
|
2013-12-26 |
2020-07-15 |
ザ ジェネラル ホスピタル コーポレイション |
多重ガイドrna
|
WO2015103153A1
(en)
*
|
2013-12-31 |
2015-07-09 |
The Regents Of The University Of California |
Cas9 crystals and methods of use thereof
|
AU2015204784B2
(en)
*
|
2014-01-08 |
2021-01-28 |
President And Fellows Of Harvard College |
RNA-guided gene drives
|
RU2016133286A
(ru)
|
2014-01-14 |
2018-02-20 |
Лэм Терапьютикс, Инк. |
Способы мутагенеза
|
US10787654B2
(en)
|
2014-01-24 |
2020-09-29 |
North Carolina State University |
Methods and compositions for sequence guiding Cas9 targeting
|
JP2017503514A
(ja)
*
|
2014-01-24 |
2017-02-02 |
ノースカロライナ ステート ユニバーシティーNorth Carolina State University |
Cas9ターゲッティングをガイドする配列に関する方法および組成物
|
US10354746B2
(en)
*
|
2014-01-27 |
2019-07-16 |
Georgia Tech Research Corporation |
Methods and systems for identifying CRISPR/Cas off-target sites
|
US11315659B2
(en)
*
|
2014-01-27 |
2022-04-26 |
Georgia Tech Research Corporation |
Methods and systems for identifying nucleotide-guided nuclease off-target sites
|
WO2015116686A1
(en)
*
|
2014-01-29 |
2015-08-06 |
Agilent Technologies, Inc. |
Cas9-based isothermal method of detection of specific dna sequence
|
WO2015119941A2
(en)
|
2014-02-04 |
2015-08-13 |
Igenomx International Genomics Corporation |
Genome fractioning
|
HUE066611T2
(hu)
*
|
2014-02-11 |
2024-08-28 |
Univ Colorado Regents |
CRISPR-aktivált multiplex genommérnökség
|
US10287590B2
(en)
|
2014-02-12 |
2019-05-14 |
Dna2.0, Inc. |
Methods for generating libraries with co-varying regions of polynuleotides for genome modification
|
CN106232814B
(zh)
|
2014-02-13 |
2021-05-11 |
宝生物工程(美国)有限公司 |
从核酸的初始集合中耗尽靶分子的方法、以及用于实践其的组合物和试剂盒
|
EP3107999A4
(en)
*
|
2014-02-18 |
2017-10-04 |
Duke University |
Compositions for the inactivation of virus replication and methods of making and using the same
|
US10370680B2
(en)
*
|
2014-02-24 |
2019-08-06 |
Sangamo Therapeutics, Inc. |
Method of treating factor IX deficiency using nuclease-mediated targeted integration
|
CA2940217C
(en)
|
2014-02-27 |
2023-06-13 |
Monsanto Technology Llc |
Compositions and methods for site directed genomic modification
|
CN103820454B
(zh)
*
|
2014-03-04 |
2016-03-30 |
上海金卫生物技术有限公司 |
CRISPR-Cas9特异性敲除人PD1基因的方法以及用于特异性靶向PD1基因的sgRNA
|
WO2015134812A1
(en)
|
2014-03-05 |
2015-09-11 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating usher syndrome and retinitis pigmentosa
|
CN106459957B
(zh)
|
2014-03-05 |
2020-03-20 |
国立大学法人神户大学 |
用于特异性转变靶向dna序列的核酸碱基的基因组序列的修饰方法、及其使用的分子复合体
|
WO2015138510A1
(en)
|
2014-03-10 |
2015-09-17 |
Editas Medicine., Inc. |
Crispr/cas-related methods and compositions for treating leber's congenital amaurosis 10 (lca10)
|
US11339437B2
(en)
|
2014-03-10 |
2022-05-24 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
US11141493B2
(en)
|
2014-03-10 |
2021-10-12 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
CA2942407C
(en)
*
|
2014-03-14 |
2023-09-26 |
Cibus Us Llc |
Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
|
EP3593812A3
(en)
|
2014-03-15 |
2020-05-27 |
Novartis AG |
Treatment of cancer using chimeric antigen receptor
|
EP3811970A1
(en)
|
2014-03-15 |
2021-04-28 |
Novartis AG |
Regulatable chimeric antigen receptor
|
EP3628334B1
(en)
*
|
2014-03-21 |
2023-06-28 |
Genzyme Corporation |
Gene therapy for retinitis pigmentosa
|
WO2015148431A1
(en)
|
2014-03-24 |
2015-10-01 |
IMMCO Diagnostics, Inc. |
Improved anti-nuclear antibody detection and diagnostics for systemic and non-systemic autoimmune disorders
|
JP2017512500A
(ja)
*
|
2014-03-25 |
2017-05-25 |
ギンゴー バイオワークス, インコーポレイテッド |
細胞工学のための方法および遺伝システム
|
US11242525B2
(en)
|
2014-03-26 |
2022-02-08 |
Editas Medicine, Inc. |
CRISPR/CAS-related methods and compositions for treating sickle cell disease
|
US11318206B2
(en)
|
2014-03-28 |
2022-05-03 |
Aposense Ltd |
Compounds and methods for trans-membrane delivery of molecules
|
CA2944141C
(en)
*
|
2014-03-28 |
2023-03-28 |
Aposense Ltd. |
Compounds and methods for trans-membrane delivery of molecules
|
WO2015153791A1
(en)
*
|
2014-04-01 |
2015-10-08 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating herpes simplex virus type 2 (hsv-2)
|
WO2015153940A1
(en)
*
|
2014-04-03 |
2015-10-08 |
Massachusetts Institute Of Technology |
Methods and compositions for the production of guide rna
|
CN107075482B
(zh)
|
2014-04-07 |
2021-03-16 |
诺华股份有限公司 |
使用抗cd19嵌合抗原受体治疗癌症
|
EP3129490A4
(en)
|
2014-04-08 |
2017-10-04 |
North Carolina State University |
Methods and compositions for rna-directed repression of transcription using crispr-associated genes
|
IL292512B2
(en)
*
|
2014-04-18 |
2024-07-01 |
Editas Medicine Inc |
Crispr–cas–related methods, compositions and components for cancer immunotherapy
|
ES2744186T3
(es)
|
2014-04-25 |
2020-02-24 |
Childrens Medical Center |
Composiciones y métodos para tratar las hemoglobinopatías
|
JP2017513510A
(ja)
|
2014-04-28 |
2017-06-01 |
リコンビネティクス・インコーポレイテッドRecombinetics,Inc. |
ブタにおける多重遺伝子編集
|
WO2015168404A1
(en)
*
|
2014-04-30 |
2015-11-05 |
Massachusetts Institute Of Technology |
Toehold-gated guide rna for programmable cas9 circuitry with rna input
|
WO2015172149A1
(en)
|
2014-05-09 |
2015-11-12 |
Yale University |
Hyperbranched polyglycerol-coated particles and methods of making and using thereof
|
US11918695B2
(en)
|
2014-05-09 |
2024-03-05 |
Yale University |
Topical formulation of hyperbranched polymer-coated particles
|
EP3142707A4
(en)
*
|
2014-05-13 |
2018-02-21 |
Sangamo Therapeutics, Inc. |
Methods and compositions for prevention or treatment of a disease
|
PL3145934T3
(pl)
|
2014-05-19 |
2021-08-16 |
Pfizer Inc. |
Podstawione związki 6,8-dioksabicyklo[3.2.1]oktano-2,3-diolu jako środki kierujące do ASGPR
|
WO2015179540A1
(en)
*
|
2014-05-20 |
2015-11-26 |
Regents Of The University Of Minnesota |
Method for editing a genetic sequence
|
CA2949713A1
(en)
|
2014-05-30 |
2015-12-03 |
The Board Of Trustees Of The Leland Stanford Junior University |
Compositions and methods of delivering treatments for latent viral infections
|
US9970001B2
(en)
|
2014-06-05 |
2018-05-15 |
Sangamo Therapeutics, Inc. |
Methods and compositions for nuclease design
|
BR112016028564A2
(pt)
*
|
2014-06-06 |
2018-01-30 |
Regeneron Pharma |
método para modificar um locus-alvo em uma célula.
|
US11274302B2
(en)
*
|
2016-08-17 |
2022-03-15 |
Diacarta Ltd |
Specific synthetic chimeric Xenonucleic acid guide RNA; s(XNA-gRNA) for enhancing CRISPR mediated genome editing efficiency
|
CA2951707A1
(en)
|
2014-06-10 |
2015-12-17 |
Massachusetts Institute Of Technology |
Method for gene editing
|
BR112016028741A2
(pt)
|
2014-06-11 |
2017-11-07 |
Univ Duke |
composições e métodos para controle de fluxo rápido e dinâmico usando válvulas metabólicas sintéticas
|
WO2015192020A1
(en)
|
2014-06-13 |
2015-12-17 |
Children's Medical Center Corporation |
Products and methods to isolate mitochondria
|
WO2015195798A1
(en)
*
|
2014-06-17 |
2015-12-23 |
Poseida Therapeutics, Inc. |
A method for directing proteins to specific loci in the genome and uses thereof
|
IL286474B2
(en)
|
2014-06-23 |
2023-11-01 |
Massachusetts Gen Hospital |
Genome-wide random identification of DSBS assessed by sequencing (guide-sequence)
|
ES2781323T3
(es)
|
2014-06-23 |
2020-09-01 |
Regeneron Pharma |
Montaje de ADN mediado por nucleasas
|
SI3161128T1
(sl)
|
2014-06-26 |
2019-02-28 |
Regeneron Pharmaceuticals, Inc. |
Postopki in sestavki za ciljano genetsko spremembo in postopki uporabe
|
MX2017000422A
(es)
|
2014-07-11 |
2017-05-01 |
Du Pont |
Composiciones y metodos para producir plantas resistentes al herbicida glifosato.
|
WO2016011070A2
(en)
*
|
2014-07-14 |
2016-01-21 |
The Regents Of The University Of California |
A protein tagging system for in vivo single molecule imaging and control of gene transcription
|
US11254933B2
(en)
*
|
2014-07-14 |
2022-02-22 |
The Regents Of The University Of California |
CRISPR/Cas transcriptional modulation
|
CA2954414A1
(en)
*
|
2014-07-15 |
2016-01-21 |
Juno Therapeutics, Inc. |
Engineered cells for adoptive cell therapy
|
US20160053272A1
(en)
*
|
2014-07-18 |
2016-02-25 |
Whitehead Institute For Biomedical Research |
Methods Of Modifying A Sequence Using CRISPR
|
US20160053304A1
(en)
*
|
2014-07-18 |
2016-02-25 |
Whitehead Institute For Biomedical Research |
Methods Of Depleting Target Sequences Using CRISPR
|
EP3193915A1
(en)
|
2014-07-21 |
2017-07-26 |
Novartis AG |
Combinations of low, immune enhancing. doses of mtor inhibitors and cars
|
WO2016014553A1
(en)
|
2014-07-21 |
2016-01-28 |
Novartis Ag |
Sortase synthesized chimeric antigen receptors
|
ES2805475T3
(es)
|
2014-07-21 |
2021-02-12 |
Novartis Ag |
Tratamiento del cáncer utilizando un receptor antigénico quimérico de CD33
|
AU2015292744C1
(en)
|
2014-07-21 |
2021-01-21 |
Novartis Ag |
Treatment of cancer using humanized anti-BCMA chimeric antigen receptor
|
SG11201702066UA
(en)
*
|
2014-07-21 |
2017-04-27 |
Illumina Inc |
Polynucleotide enrichment using crispr-cas systems
|
WO2016022363A2
(en)
|
2014-07-30 |
2016-02-11 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
US20170209492A1
(en)
|
2014-07-31 |
2017-07-27 |
Novartis Ag |
Subset-optimized chimeric antigen receptor-containing t-cells
|
US20160076093A1
(en)
*
|
2014-08-04 |
2016-03-17 |
University Of Washington |
Multiplex homology-directed repair
|
JP6715419B2
(ja)
|
2014-08-06 |
2020-07-01 |
トゥールジェン インコーポレイテッド |
カンピロバクター・ジェジュニcrispr/casシステムに由来するrgenを使用したゲノム編集
|
WO2016022866A1
(en)
*
|
2014-08-07 |
2016-02-11 |
Agilent Technologies, Inc. |
Cis-blocked guide rna
|
US10513711B2
(en)
|
2014-08-13 |
2019-12-24 |
Dupont Us Holding, Llc |
Genetic targeting in non-conventional yeast using an RNA-guided endonuclease
|
AU2015301460B2
(en)
|
2014-08-14 |
2021-04-08 |
Novartis Ag |
Treatment of cancer using GFR alpha-4 chimeric antigen receptor
|
US11071289B2
(en)
|
2014-08-14 |
2021-07-27 |
Biocytogen Boston Corp |
DNA knock-in system
|
US9879270B2
(en)
*
|
2014-08-15 |
2018-01-30 |
Wisconsin Alumni Research Foundation |
Constructs and methods for genome editing and genetic engineering of fungi and protists
|
CA2958292A1
(en)
|
2014-08-19 |
2016-02-25 |
President And Fellows Of Harvard College |
Rna-guided systems for probing and mapping of nucleic acids
|
RU2020117196A
(ru)
|
2014-08-19 |
2020-10-15 |
Новартис Аг |
Химерный антигенный рецептор (car) против cd123 для использования в лечении злокачественных опухолей
|
WO2016028887A1
(en)
|
2014-08-19 |
2016-02-25 |
Pacific Biosciences Of California, Inc. |
Compositions and methods for enrichment of nucleic acids
|
US10435685B2
(en)
|
2014-08-19 |
2019-10-08 |
Pacific Biosciences Of California, Inc. |
Compositions and methods for enrichment of nucleic acids
|
AU2015308910B2
(en)
|
2014-08-27 |
2017-12-07 |
Caribou Biosciences, Inc. |
Methods for increasing Cas9-mediated engineering efficiency
|
EP3186375A4
(en)
*
|
2014-08-28 |
2019-03-13 |
North Carolina State University |
Novel CAS9 PROTEINS AND CHARACTERISTICS FOR DNA TARGETING AND GENOME EDITING
|
US10570418B2
(en)
|
2014-09-02 |
2020-02-25 |
The Regents Of The University Of California |
Methods and compositions for RNA-directed target DNA modification
|
AU2015315651A1
(en)
|
2014-09-12 |
2017-02-16 |
E. I. Du Pont De Nemours And Company |
Generation of site-specific-integration sites for complex trait loci in corn and soybean, and methods of use
|
WO2016044605A1
(en)
|
2014-09-17 |
2016-03-24 |
Beatty, Gregory |
Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
|
WO2016049024A2
(en)
*
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling competition of multiple cancer mutations in vivo
|
US10370673B2
(en)
|
2014-09-26 |
2019-08-06 |
Purecircle Sdn Bhd |
Single nucleotide polymorphism (SNP) markers for stevia
|
SG10201902811TA
(en)
|
2014-09-29 |
2019-04-29 |
Jackson Lab |
High efficiency, high throughput generation of genetically modified mammals by electroporation
|
US20170233762A1
(en)
*
|
2014-09-29 |
2017-08-17 |
The Regents Of The University Of California |
Scaffold rnas
|
JP6716577B2
(ja)
|
2014-10-01 |
2020-07-01 |
イーグル・バイオロジクス・インコーポレイテッドEagle Biologics, Inc. |
粘度低下物質を含有する、多糖および核酸の調合薬
|
WO2016050512A1
(en)
|
2014-10-03 |
2016-04-07 |
Bayer Cropscience Nv |
Methods and means for increasing stress tolerance and biomass in plants
|
AU2015330699B2
(en)
|
2014-10-10 |
2021-12-02 |
Editas Medicine, Inc. |
Compositions and methods for promoting homology directed repair
|
US10428310B2
(en)
|
2014-10-15 |
2019-10-01 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for generating or maintaining pluripotent cells
|
US11174506B2
(en)
*
|
2014-10-17 |
2021-11-16 |
Howard Hughes Medical Institute |
Genomic probes
|
GB201418965D0
(sr)
|
2014-10-24 |
2014-12-10 |
Ospedale San Raffaele And Fond Telethon |
|
WO2016065364A1
(en)
*
|
2014-10-24 |
2016-04-28 |
Life Technologies Corporation |
Compositions and methods for enhancing homologous recombination
|
PL3215166T3
(pl)
|
2014-10-31 |
2024-08-26 |
The Trustees Of The University Of Pennsylvania |
Zmiana ekspresji genów w limfocytach car-t i ich zastosowanie
|
EP3708155A1
(en)
|
2014-10-31 |
2020-09-16 |
Massachusetts Institute Of Technology |
Massively parallel combinatorial genetics for crispr
|
WO2016073559A1
(en)
*
|
2014-11-05 |
2016-05-12 |
The Regents Of The University Of California |
Methods for autocatalytic genome editing and neutralizing autocatalytic genome editing
|
EP3597740B1
(en)
*
|
2014-11-06 |
2022-03-23 |
DuPont US Holding, LLC |
Peptide-mediated delivery of rna-guided endonuclease into cells
|
WO2016073990A2
(en)
|
2014-11-07 |
2016-05-12 |
Editas Medicine, Inc. |
Methods for improving crispr/cas-mediated genome-editing
|
US11470826B2
(en)
*
|
2014-11-17 |
2022-10-18 |
National University Corporation Tokyo Medical And Dental University |
Method of conveniently producing genetically modified non-human mammal with high efficiency
|
CN104531632A
(zh)
*
|
2014-11-18 |
2015-04-22 |
李云英 |
快速降解的Cas9-ODC422-461融合蛋白及其应用
|
EP3521437B1
(en)
|
2014-11-21 |
2025-01-15 |
Regeneron Pharmaceuticals, Inc. |
Methods for targeted genetic modification using paired guide rnas
|
EP3224353B9
(en)
*
|
2014-11-26 |
2023-08-09 |
Technology Innovation Momentum Fund (Israel) Limited Partnership |
Targeted elimination of bacterial genes
|
GB201421096D0
(en)
|
2014-11-27 |
2015-01-14 |
Imp Innovations Ltd |
Genome editing methods
|
US10479997B2
(en)
|
2014-12-01 |
2019-11-19 |
Novartis Ag |
Compositions and methods for diagnosis and treatment of prostate cancer
|
EP4400584A3
(en)
|
2014-12-03 |
2024-10-16 |
Agilent Technologies, Inc. |
Guide rna with chemical modifications
|
WO2016094679A1
(en)
|
2014-12-10 |
2016-06-16 |
Regents Of The University Of Minnesota |
Genetically modified cells, tissues, and organs for treating disease
|
EP3230451B1
(en)
|
2014-12-12 |
2021-04-07 |
The Broad Institute, Inc. |
Protected guide rnas (pgrnas)
|
KR101796518B1
(ko)
*
|
2014-12-12 |
2017-11-14 |
한국한의학연구원 |
일체형 유전자 치료 유도만능줄기세포 제작방법
|
JP6997623B2
(ja)
*
|
2014-12-12 |
2022-02-04 |
エム. ウルフ、トッド |
オリゴヌクレオチドを利用して細胞内の核酸を編集するための組成物および方法
|
WO2016094874A1
(en)
*
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Escorted and functionalized guides for crispr-cas systems
|
EP3234136B1
(en)
|
2014-12-16 |
2024-08-21 |
C3J Therapeutics, Inc. |
Compositions of and methods for in vitro viral genome engineering
|
MX2017007907A
(es)
*
|
2014-12-17 |
2017-09-18 |
Du Pont |
Composiciones y métodos para la edición genética eficaz en e. coli usando sistemas de ácido desoxirribonucleico (arn) guía/endonucleasa de sistema asociado a repeticiones palindrómicas cortas agrupadas regularmente espaciadas (cas) en combinación con moldes de modificación de polinucleótido circular.
|
WO2016097751A1
(en)
*
|
2014-12-18 |
2016-06-23 |
The University Of Bath |
Method of cas9 mediated genome engineering
|
EP3786296A1
(en)
|
2014-12-18 |
2021-03-03 |
Integrated Dna Technologies, Inc. |
Crispr-based compositions and methods of use
|
US20190054117A1
(en)
|
2014-12-19 |
2019-02-21 |
Novartis Ag |
Dimerization switches and uses thereof
|
AU2015364427B2
(en)
|
2014-12-19 |
2021-05-27 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for targeted genetic modification through single-step multiple targeting
|
WO2016100857A1
(en)
|
2014-12-19 |
2016-06-23 |
Regeneron Pharmaceuticals, Inc. |
Stem cells for modeling type 2 diabetes
|
EP3957745A1
(en)
|
2014-12-20 |
2022-02-23 |
Arc Bio, LLC |
Compositions and methods for targeted depletion, enrichment, and partitioning of nucleic acids using crispr/cas system proteins
|
ES2785329T3
(es)
|
2014-12-23 |
2020-10-06 |
Syngenta Participations Ag |
Métodos y composiciones para identificar y enriquecer células que comprenden modificaciones genómicas específicas para el sitio
|
WO2016106244A1
(en)
|
2014-12-24 |
2016-06-30 |
The Broad Institute Inc. |
Crispr having or associated with destabilization domains
|
AU2015373893B2
(en)
|
2014-12-31 |
2021-07-29 |
Synthetic Genomics, Inc. |
Compositions and methods for high efficiency in vivo genome editing
|
DK3242950T3
(da)
*
|
2015-01-06 |
2021-12-20 |
Dsm Ip Assets Bv |
Crispr-cas-system til en trådformet svampeværtscelle
|
US11208638B2
(en)
|
2015-01-12 |
2021-12-28 |
The Regents Of The University Of California |
Heterodimeric Cas9 and methods of use thereof
|
MA41349A
(fr)
*
|
2015-01-14 |
2017-11-21 |
Univ Temple |
Éradication de l'herpès simplex de type i et d'autres virus de l'herpès associés guidée par arn
|
EP4219730A1
(en)
|
2015-01-27 |
2023-08-02 |
Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences |
Method for conducting site-specific modification on entire plant via gene transient expression
|
US10059940B2
(en)
*
|
2015-01-27 |
2018-08-28 |
Minghong Zhong |
Chemically ligated RNAs for CRISPR/Cas9-lgRNA complexes as antiviral therapeutic agents
|
WO2016123243A1
(en)
|
2015-01-28 |
2016-08-04 |
The Regents Of The University Of California |
Methods and compositions for labeling a single-stranded target nucleic acid
|
AU2016211517B2
(en)
|
2015-01-28 |
2021-05-13 |
Caribou Biosciences, Inc. |
CRISPR hybrid DNA/RNA polynucleotides and methods of use
|
AU2016211161C1
(en)
*
|
2015-01-30 |
2023-11-23 |
The Regents Of The University Of California |
Protein delivery in primary hematopoietic cells
|
WO2016126747A1
(en)
*
|
2015-02-02 |
2016-08-11 |
Meiragtx Uk Limited |
Regulation of gene expression by aptamer-mediated modulation of alternative splicing
|
CN114891816B
(zh)
|
2015-02-06 |
2025-01-21 |
新加坡国立大学 |
核酸、包含其的工程免疫细胞及其制备方法和用途
|
EP3256487A4
(en)
|
2015-02-09 |
2018-07-18 |
Duke University |
Compositions and methods for epigenome editing
|
WO2016133165A1
(ja)
*
|
2015-02-19 |
2016-08-25 |
国立大学法人徳島大学 |
Cas9 mRNAを哺乳動物の受精卵にエレクトロポレーションにより導入する方法
|
US20180030438A1
(en)
|
2015-02-23 |
2018-02-01 |
Crispr Therapeutics Ag |
Materials and methods for treatment of hemoglobinopathies
|
US12129471B2
(en)
|
2015-02-23 |
2024-10-29 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of human genetic diseases including hemoglobinopathies
|
US20180245073A1
(en)
*
|
2015-02-23 |
2018-08-30 |
Voyager Therapeutics, Inc. |
Regulatable expression using adeno-associated virus (aav)
|
US10968536B2
(en)
|
2015-02-25 |
2021-04-06 |
Jumpcode Genomics, Inc. |
Methods and compositions for sequencing
|
AU2016226077B2
(en)
|
2015-03-03 |
2021-12-23 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases with altered PAM specificity
|
WO2016142427A1
(en)
|
2015-03-10 |
2016-09-15 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Method ank kit for reprogramming somatic cells
|
EP3268472B1
(en)
|
2015-03-13 |
2021-05-05 |
The Jackson Laboratory |
A three-component crispr/cas complex system and uses thereof
|
EP3279321A4
(en)
|
2015-03-16 |
2018-10-31 |
Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences |
Method of applying non-genetic substance to perform site-directed reform of plant genome
|
WO2016149422A1
(en)
*
|
2015-03-16 |
2016-09-22 |
The Broad Institute, Inc. |
Encoding of dna vector identity via iterative hybridization detection of a barcode transcript
|
CN113846144B
(zh)
|
2015-03-17 |
2023-09-26 |
生物辐射实验室股份有限公司 |
检测基因组编辑
|
AU2016235163B2
(en)
|
2015-03-24 |
2022-03-24 |
The Regents Of The University Of California |
Adeno-associated virus variants and methods of use thereof
|
EP4019635A1
(en)
*
|
2015-03-25 |
2022-06-29 |
Editas Medicine, Inc. |
Crispr/cas-related methods, compositions and components
|
BR112017017260A2
(pt)
|
2015-03-27 |
2018-04-17 |
Du Pont |
construções de dna, vetor, célula, plantas, semente, método de expressão de rna e método de modificação de local alvo
|
JP2018513681A
(ja)
|
2015-03-31 |
2018-05-31 |
エクセリゲン サイエンティフィック, インコーポレイテッドExeligen Scientific, Inc. |
細胞または生物のゲノムへのDNA配列の標的化組み込みのためのCas9レトロウイルスインテグラーゼおよびCas9レコンビナーゼ系
|
WO2016164356A1
(en)
|
2015-04-06 |
2016-10-13 |
The Board Of Trustees Of The Leland Stanford Junior University |
Chemically modified guide rnas for crispr/cas-mediated gene regulation
|
WO2016167300A1
(ja)
*
|
2015-04-13 |
2016-10-20 |
国立大学法人東京大学 |
光依存的に又は薬物存在下でヌクレアーゼ活性若しくはニッカーゼ活性を示す、又は標的遺伝子の発現を抑制若しくは活性化するポリペプチドのセット
|
AU2016249402B2
(en)
|
2015-04-15 |
2021-09-09 |
Synthetic Genomics, Inc. |
Algal chloroplastic SRP54 mutants
|
US11674144B2
(en)
*
|
2015-04-16 |
2023-06-13 |
California Institute Of Technology |
Fractional regulation of transcription
|
WO2016172583A1
(en)
|
2015-04-23 |
2016-10-27 |
Novartis Ag |
Treatment of cancer using chimeric antigen receptor and protein kinase a blocker
|
AU2016253150B2
(en)
*
|
2015-04-24 |
2022-04-21 |
Editas Medicine, Inc. |
Evaluation of Cas9 molecule/guide RNA molecule complexes
|
WO2016176652A2
(en)
|
2015-04-29 |
2016-11-03 |
Fred Hutchinson Cancer Research Center |
Modified stem cells and uses thereof
|
US11845928B2
(en)
*
|
2015-05-04 |
2023-12-19 |
Tsinghua University |
Methods and kits for fragmenting DNA
|
CA2984975A1
(en)
|
2015-05-06 |
2016-11-10 |
Snipr Technologies Limited |
Altering microbial populations & modifying microbiota
|
EP3294873B2
(en)
*
|
2015-05-08 |
2024-09-18 |
The Children's Medical Center Corporation |
Targeting bcl11a enhancer functional regions for fetal hemoglobin reinduction
|
US11253616B2
(en)
|
2017-09-06 |
2022-02-22 |
The Trustees Of The University Of Pennsylvania |
Small molecules for dual function positron emission tomography (PET) and cell suicide switches
|
WO2016182959A1
(en)
|
2015-05-11 |
2016-11-17 |
Editas Medicine, Inc. |
Optimized crispr/cas9 systems and methods for gene editing in stem cells
|
WO2016183402A2
(en)
*
|
2015-05-13 |
2016-11-17 |
President And Fellows Of Harvard College |
Methods of making and using guide rna for use with cas9 systems
|
WO2016183448A1
(en)
*
|
2015-05-14 |
2016-11-17 |
University Of Southern California |
Optimized gene editing utilizing a recombinant endonuclease system
|
CN107849546A
(zh)
|
2015-05-15 |
2018-03-27 |
先锋国际良种公司 |
对cas内切核酸酶系统、pam序列和指导rna元件的快速表征
|
EP3294880A4
(en)
*
|
2015-05-15 |
2018-12-26 |
Dharmacon, Inc. |
Synthetic single guide rna for cas9-mediated gene editing
|
EP3095870A1
(en)
|
2015-05-19 |
2016-11-23 |
Kws Saat Se |
Methods for the in planta transformation of plants and manufacturing processes and products based and obtainable therefrom
|
US10966414B2
(en)
|
2015-05-26 |
2021-04-06 |
California Institute Of Technology |
Population control using engineered translocations
|
US10117911B2
(en)
|
2015-05-29 |
2018-11-06 |
Agenovir Corporation |
Compositions and methods to treat herpes simplex virus infections
|
JP2018516563A
(ja)
|
2015-05-29 |
2018-06-28 |
ノース カロライナ ステート ユニバーシティNorth Carolina State University |
Crispr核酸を用いて、細菌、古細菌、藻類、および、酵母をスクリーニングする方法
|
US10883103B2
(en)
|
2015-06-02 |
2021-01-05 |
Monsanto Technology Llc |
Compositions and methods for delivery of a polynucleotide into a plant
|
US10392607B2
(en)
|
2015-06-03 |
2019-08-27 |
The Regents Of The University Of California |
Cas9 variants and methods of use thereof
|
WO2016196887A1
(en)
*
|
2015-06-03 |
2016-12-08 |
Board Of Regents Of The University Of Nebraska |
Dna editing using single-stranded dna
|
EP3302525A2
(en)
|
2015-06-05 |
2018-04-11 |
Novartis AG |
Methods and compositions for diagnosing, treating, and monitoring treatment of shank3 deficiency associated disorders
|
US11911415B2
(en)
|
2015-06-09 |
2024-02-27 |
Editas Medicine, Inc. |
CRISPR/Cas-related methods and compositions for improving transplantation
|
US20160362667A1
(en)
|
2015-06-10 |
2016-12-15 |
Caribou Biosciences, Inc. |
CRISPR-Cas Compositions and Methods
|
GB201510296D0
(en)
*
|
2015-06-12 |
2015-07-29 |
Univ Wageningen |
Thermostable CAS9 nucleases
|
EP3307893A4
(en)
|
2015-06-12 |
2019-08-21 |
Lonza Walkersville, Inc. |
PROCESS FOR NUCLEAR REPROGRAMMING WITH SYNTHETIC TRANSCRIPTION FACTORS
|
WO2016205276A1
(en)
|
2015-06-15 |
2016-12-22 |
North Carolina State University |
Methods and compositions for efficient delivery of nucleic acids and rna-based antimicrobials
|
JP2018521689A
(ja)
*
|
2015-06-17 |
2018-08-09 |
ポセイダ セラピューティクス, インコーポレイテッド |
タンパク質をゲノム内の特定の遺伝子座に導くための組成物および方法
|
CA2989831A1
(en)
|
2015-06-17 |
2016-12-22 |
The Uab Research Foundation |
Crispr/cas9 complex for genomic editing
|
CN108026545A
(zh)
|
2015-06-17 |
2018-05-11 |
Uab研究基金会 |
用于将功能性多肽引入到血细胞谱系细胞中的crispr/cas9复合物
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
US9790490B2
(en)
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
KR20230132877A
(ko)
|
2015-06-18 |
2023-09-18 |
더 브로드 인스티튜트, 인코퍼레이티드 |
표적외 효과를 감소시키는 crispr 효소 돌연변이
|
WO2016205749A1
(en)
*
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
WO2017004279A2
(en)
*
|
2015-06-29 |
2017-01-05 |
Massachusetts Institute Of Technology |
Compositions comprising nucleic acids and methods of using the same
|
US11414657B2
(en)
|
2015-06-29 |
2022-08-16 |
Ionis Pharmaceuticals, Inc. |
Modified CRISPR RNA and modified single CRISPR RNA and uses thereof
|
JP6765665B2
(ja)
*
|
2015-07-13 |
2020-10-07 |
国立研究開発法人農業・食品産業技術総合研究機構 |
不稔化植物、不稔化植物の作出方法、及びベクター
|
MA42895A
(fr)
|
2015-07-15 |
2018-05-23 |
Juno Therapeutics Inc |
Cellules modifiées pour thérapie cellulaire adoptive
|
US11479793B2
(en)
|
2015-07-15 |
2022-10-25 |
Rutgers, The State University Of New Jersey |
Nuclease-independent targeted gene editing platform and uses thereof
|
WO2017015101A1
(en)
*
|
2015-07-17 |
2017-01-26 |
University Of Washington |
Methods for maximizing the efficiency of targeted gene correction
|
WO2017015637A1
(en)
|
2015-07-22 |
2017-01-26 |
Duke University |
High-throughput screening of regulatory element function with epigenome editing technologies
|
EP4339287A3
(en)
|
2015-07-31 |
2024-05-22 |
Regents Of The University Of Minnesota |
Modified cells and methods of therapy
|
WO2017024047A1
(en)
*
|
2015-08-03 |
2017-02-09 |
Emendobio Inc. |
Compositions and methods for increasing nuclease induced recombination rate in cells
|
WO2017024318A1
(en)
|
2015-08-06 |
2017-02-09 |
Dana-Farber Cancer Institute, Inc. |
Targeted protein degradation to attenuate adoptive t-cell therapy associated adverse inflammatory responses
|
US10130651B2
(en)
|
2015-08-07 |
2018-11-20 |
Arrowhead Pharmaceuticals, Inc. |
RNAi Therapy for Hepatitis B Virus Infection
|
US9580727B1
(en)
|
2015-08-07 |
2017-02-28 |
Caribou Biosciences, Inc. |
Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides
|
US11667691B2
(en)
|
2015-08-07 |
2023-06-06 |
Novartis Ag |
Treatment of cancer using chimeric CD3 receptor proteins
|
EP3334746B1
(en)
|
2015-08-14 |
2021-11-24 |
The University Of Sydney |
Connexin 45 inhibition for therapy
|
WO2017028768A1
(en)
*
|
2015-08-14 |
2017-02-23 |
Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences |
Method for obtaining glyphosate-resistant rice by site-directed nucleotide substitution
|
JP6986509B2
(ja)
|
2015-08-19 |
2021-12-22 |
アーク バイオ, エルエルシー |
核酸ガイド化ヌクレアーゼをベースとした系を使用する核酸の捕捉
|
WO2017031341A1
(en)
|
2015-08-19 |
2017-02-23 |
Children's Research Institute, Children's National Medical Center |
Compositions and methods for treating graft versus host disease
|
EA201890565A1
(ru)
*
|
2015-08-25 |
2019-04-30 |
Дьюк Юниверсити |
Композиции и способы улучшения специфичности в геномной инженерии с применением рнк-направляемых эндонуклеаз
|
WO2017040343A1
(en)
|
2015-08-28 |
2017-03-09 |
Pioneer Hi-Bred International, Inc. |
Ochrobactrum-mediated transformation of plants
|
US9926546B2
(en)
|
2015-08-28 |
2018-03-27 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
EP4036236A1
(en)
*
|
2015-08-28 |
2022-08-03 |
The General Hospital Corporation |
Engineered crispr-cas9 nucleases
|
US9512446B1
(en)
|
2015-08-28 |
2016-12-06 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
WO2017040709A1
(en)
|
2015-08-31 |
2017-03-09 |
Caribou Biosciences, Inc. |
Directed nucleic acid repair
|
WO2017040511A1
(en)
|
2015-08-31 |
2017-03-09 |
Agilent Technologies, Inc. |
Compounds and methods for crispr/cas-based genome editing by homologous recombination
|
EP3347464B1
(en)
*
|
2015-09-08 |
2024-01-24 |
University of Massachusetts |
Dnase h activity of neisseria meningitidis cas9
|
US10767173B2
(en)
|
2015-09-09 |
2020-09-08 |
National University Corporation Kobe University |
Method for converting genome sequence of gram-positive bacterium by specifically converting nucleic acid base of targeted DNA sequence, and molecular complex used in same
|
CN108348167B
(zh)
*
|
2015-09-09 |
2022-06-03 |
普梭梅根公司 |
用于脑-颅面健康相关病症的源自微生物群系的诊断及治疗方法和系统
|
CN108348166B
(zh)
*
|
2015-09-09 |
2022-06-03 |
普梭梅根公司 |
用于与抗生素使用相关的感染性疾病及其它健康状况的源自微生物群系的诊断及治疗方法和系统
|
WO2017044776A1
(en)
*
|
2015-09-10 |
2017-03-16 |
Texas Tech University System |
Single-guide rna (sgrna) with improved knockout efficiency
|
CA3000816A1
(en)
|
2015-09-11 |
2017-03-16 |
The General Hospital Corporation |
Full interrogation of nuclease dsbs and sequencing (find-seq)
|
DK3349802T3
(en)
|
2015-09-14 |
2021-10-11 |
Univ Texas |
Lipocationic dendrimers and uses thereof
|
EP3352795B1
(en)
*
|
2015-09-21 |
2020-08-12 |
The Regents of The University of California |
Compositions and methods for target nucleic acid modification
|
CA2999500A1
(en)
|
2015-09-24 |
2017-03-30 |
Editas Medicine, Inc. |
Use of exonucleases to improve crispr/cas-mediated genome editing
|
WO2017053729A1
(en)
|
2015-09-25 |
2017-03-30 |
The Board Of Trustees Of The Leland Stanford Junior University |
Nuclease-mediated genome editing of primary cells and enrichment thereof
|
WO2017058751A1
(en)
*
|
2015-09-28 |
2017-04-06 |
North Carolina State University |
Methods and compositions for sequence specific antimicrobials
|
WO2017058791A1
(en)
*
|
2015-09-29 |
2017-04-06 |
Agenovir Corporation |
Compositions and methods for treatment of latent viral infections
|
KR20180053748A
(ko)
|
2015-09-30 |
2018-05-23 |
더 제너럴 하스피탈 코포레이션 |
시퀀싱(circle-seq)에 의한 절단 반응의 포괄적인 시험관내 보고
|
EP3356520B1
(en)
|
2015-10-02 |
2022-03-23 |
The U.S.A. as represented by the Secretary, Department of Health and Human Services |
Lentiviral protein delivery system for rna-guided genome editing
|
US11692182B2
(en)
*
|
2015-10-09 |
2023-07-04 |
Monsanto Technology Llc |
RNA-guided DNA nucleases and uses thereof
|
US20180273979A1
(en)
|
2015-10-12 |
2018-09-27 |
E I Du Pont De Nemours And Company |
Protected dna templates for gene modification and increased homologous recombination in cells and methods of use
|
WO2017066497A2
(en)
|
2015-10-13 |
2017-04-20 |
Duke University |
Genome engineering with type i crispr systems in eukaryotic cells
|
US9862941B2
(en)
|
2015-10-14 |
2018-01-09 |
Pioneer Hi-Bred International, Inc. |
Single cell microfluidic device
|
CA3001859A1
(en)
|
2015-10-16 |
2017-04-20 |
The Trustees Of Columbia University In The City Of New York |
Compositions and methods for inhibition of lineage specific antigens
|
FR3042506B1
(fr)
*
|
2015-10-16 |
2018-11-30 |
IFP Energies Nouvelles |
Outil genetique de transformation de bacteries clostridium
|
MX2018004809A
(es)
|
2015-10-20 |
2018-06-08 |
Pionner Hi Bred Int Inc |
Metodos y composiciones para la modificacion genomica exenta de marcadores.
|
WO2017068077A1
(en)
|
2015-10-20 |
2017-04-27 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Methods and products for genetic engineering
|
EP3365441A1
(en)
*
|
2015-10-22 |
2018-08-29 |
The Broad Institute Inc. |
Type vi-b crispr enzymes and systems
|
EP3365461B1
(en)
|
2015-10-22 |
2020-10-14 |
Institut National de la Sante et de la Recherche Medicale (INSERM) |
Endonuclease-barcoding
|
EP3350327B1
(en)
|
2015-10-23 |
2018-09-26 |
Caribou Biosciences, Inc. |
Engineered crispr class 2 cross-type nucleic-acid targeting nucleic acids
|
IL310721A
(en)
|
2015-10-23 |
2024-04-01 |
Harvard College |
Nucleobase editors and their uses
|
US11369692B2
(en)
|
2015-10-28 |
2022-06-28 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of Duchenne Muscular Dystrophy
|
AU2016349288A1
(en)
|
2015-11-03 |
2018-05-31 |
President And Fellows Of Harvard College |
Method and apparatus for volumetric imaging of a three-dimensional nucleic acid containing matrix
|
US12043843B2
(en)
|
2015-11-04 |
2024-07-23 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of hemoglobinopathies
|
CA2999649A1
(en)
|
2015-11-06 |
2017-05-11 |
Crispr Therapeutics Ag |
Materials and methods for treatment of glycogen storage disease type 1a
|
WO2017079026A1
(en)
|
2015-11-06 |
2017-05-11 |
E. I. Du Pont De Nemours And Company |
Generation of complex trait loci in soybean and methods of use
|
CN108471731A
(zh)
|
2015-11-06 |
2018-08-31 |
杰克逊实验室 |
大型基因组dna敲入及其用途
|
WO2017081288A1
(en)
|
2015-11-11 |
2017-05-18 |
Lonza Ltd |
Crispr-associated (cas) proteins with reduced immunogenicity
|
US10851367B2
(en)
|
2015-11-12 |
2020-12-01 |
Pfizer Inc. |
Tissue-specific genome engineering using CRISPR-Cas9
|
US11306308B2
(en)
*
|
2015-11-13 |
2022-04-19 |
Massachusetts Institute Of Technology |
High-throughput CRISPR-based library screening
|
JP7418957B2
(ja)
|
2015-11-16 |
2024-01-22 |
リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル |
タイチン系ミオパチー及び他のタイチノパチーの治療のための材料及び方法
|
US10669320B2
(en)
|
2015-11-18 |
2020-06-02 |
The Regents Of The University Of Michigan |
Mps1 and KNL1 phosphorylation system
|
JP6923205B2
(ja)
|
2015-11-27 |
2021-08-18 |
国立大学法人神戸大学 |
標的化したdna配列の核酸塩基を特異的に変換する、単子葉植物のゲノム配列の変換方法、及びそれに用いる分子複合体
|
US11529412B2
(en)
|
2015-11-30 |
2022-12-20 |
Seed Health, Inc. |
Method and system for protecting honey bees from pesticides
|
EP3397261A4
(en)
|
2015-11-30 |
2019-07-03 |
Flagship Pioneering Innovations V, Inc. |
METHODS AND COMPOSITIONS RELATED TO CHOIC DRISOMES
|
US10675347B2
(en)
|
2015-11-30 |
2020-06-09 |
Joseph E. Kovarik |
Method and system for protecting honey bees from fipronil pesticides
|
KR20180081618A
(ko)
|
2015-11-30 |
2018-07-16 |
듀크 유니버시티 |
유전자 편집에 의한 인간 디스트로핀 유전자의 교정을 위한 치료용 표적 및 사용 방법
|
US10933128B2
(en)
|
2015-11-30 |
2021-03-02 |
Joseph E. Kovarik |
Method and system for protecting honey bees from pesticides
|
US10086024B2
(en)
|
2015-11-30 |
2018-10-02 |
Joseph E. Kovarik |
Method and system for protecting honey bees, bats and butterflies from neonicotinoid pesticides
|
US10568916B2
(en)
|
2015-11-30 |
2020-02-25 |
Joseph E. Kovarik |
Method and system for protecting honey bees, bats and butterflies from neonicotinoid pesticides
|
CN109715801B
(zh)
|
2015-12-01 |
2022-11-01 |
克里斯普治疗股份公司 |
用于治疗α1抗胰蛋白酶缺乏的材料和方法
|
US10946042B2
(en)
|
2015-12-01 |
2021-03-16 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for selective phagocytosis of human cancer cells
|
NZ756843A
(en)
*
|
2015-12-04 |
2021-07-30 |
Caribou Biosciences Inc |
Engineered nucleic-acid targeting nucleic acids
|
US9988624B2
(en)
|
2015-12-07 |
2018-06-05 |
Zymergen Inc. |
Microbial strain improvement by a HTP genomic engineering platform
|
US10787662B2
(en)
|
2015-12-07 |
2020-09-29 |
Arc Bio, Llc |
Methods and compositions for the making and using of guide nucleic acids
|
JP6821598B2
(ja)
|
2015-12-07 |
2021-01-27 |
ザイマージェン インコーポレイテッド |
Corynebacterium glutamicum由来のプロモーター
|
US11208649B2
(en)
|
2015-12-07 |
2021-12-28 |
Zymergen Inc. |
HTP genomic engineering platform
|
DK3387134T3
(da)
|
2015-12-11 |
2020-12-21 |
Danisco Us Inc |
Fremgangsmåder og sammensætninger til øget nukleasemedieret genommodifikation og reducerede virkninger uden for målstedet
|
EP3708665A1
(en)
|
2015-12-18 |
2020-09-16 |
Danisco US Inc. |
Methods and compositions for t-rna based guide rna expression
|
JP6700306B2
(ja)
*
|
2015-12-18 |
2020-05-27 |
国立研究開発法人科学技術振興機構 |
受精前の卵細胞、受精卵、及び標的遺伝子の改変方法
|
WO2017106767A1
(en)
*
|
2015-12-18 |
2017-06-22 |
The Scripps Research Institute |
Production of unnatural nucleotides using a crispr/cas9 system
|
EP3390624A4
(en)
|
2015-12-18 |
2019-07-10 |
The Regents of The University of California |
Modified site-directed modifying polypeptides and methods of use thereof
|
AU2016370726B2
(en)
*
|
2015-12-18 |
2022-12-08 |
Danisco Us Inc. |
Methods and compositions for polymerase II (Pol-II) based guide RNA expression
|
IL299646A
(en)
|
2015-12-18 |
2023-03-01 |
Oncosec Medical Inc |
Plasmid constructs for heterologous protein expression and methods of use
|
WO2017112620A1
(en)
|
2015-12-22 |
2017-06-29 |
North Carolina State University |
Methods and compositions for delivery of crispr based antimicrobials
|
WO2017112944A1
(en)
|
2015-12-23 |
2017-06-29 |
Fred Hutchinson Cancer Research Center |
High affinity t cell receptors and uses thereof
|
US20210260219A1
(en)
|
2015-12-23 |
2021-08-26 |
Crispr Therapeutics Ag |
Materials and methods for treatment of amyotrophic lateral sclerosis and/or frontal temporal lobular degeneration
|
US20190000880A1
(en)
|
2015-12-30 |
2019-01-03 |
Novartis Ag |
Immune effector cell therapies with enhanced efficacy
|
CA3009194A1
(en)
|
2016-01-11 |
2017-07-20 |
The Board Of Trustees Of The Leland Stanford Junior University |
Chimeric proteins and methods of regulating gene expression
|
EP3402494B1
(en)
|
2016-01-11 |
2021-04-07 |
The Board of Trustees of the Leland Stanford Junior University |
Chimeric proteins and methods of immunotherapy
|
US11441146B2
(en)
|
2016-01-11 |
2022-09-13 |
Christiana Care Health Services, Inc. |
Compositions and methods for improving homogeneity of DNA generated using a CRISPR/Cas9 cleavage system
|
WO2017123609A1
(en)
*
|
2016-01-12 |
2017-07-20 |
The Regents Of The University Of California |
Compositions and methods for enhanced genome editing
|
CN109414001A
(zh)
|
2016-01-15 |
2019-03-01 |
杰克逊实验室 |
通过cas9蛋白的多循环电穿孔产生的遗传修饰的非人哺乳动物
|
WO2017124037A1
(en)
|
2016-01-15 |
2017-07-20 |
The Children's Medical Center Corporation |
Therapeutic use of mitochondria and combined mitochondrial agents
|
EP3199632A1
(en)
|
2016-01-26 |
2017-08-02 |
ACIB GmbH |
Temperature-inducible crispr/cas system
|
BR112018015348A2
(pt)
|
2016-01-26 |
2018-12-18 |
Pioneer Hi Bred Int |
método para obter uma planta de milho ceroso, planta, semente, polinucleotídeo-guia e método para produzir uma planta híbrida de milho ceroso
|
CA3013179A1
(en)
*
|
2016-01-30 |
2017-08-03 |
Bonac Corporation |
Artificial single guide rna and use thereof
|
US20190038771A1
(en)
|
2016-02-02 |
2019-02-07 |
Crispr Therapeutics Ag |
Materials and methods for treatment of severe combined immunodeficiency (scid) or omenn syndrome
|
US11845933B2
(en)
|
2016-02-03 |
2023-12-19 |
Massachusetts Institute Of Technology |
Structure-guided chemical modification of guide RNA and its applications
|
JP7558637B2
(ja)
|
2016-02-09 |
2024-10-01 |
キブス ユーエス エルエルシー |
オリゴヌクレオチド介在性遺伝子修復を利用した標的遺伝子修飾の効率を上昇させるための方法および組成物
|
JP2019513345A
(ja)
*
|
2016-02-10 |
2019-05-30 |
ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン |
核酸の検知
|
WO2017139309A1
(en)
|
2016-02-12 |
2017-08-17 |
Ceres, Inc. |
Methods and materials for high throughput testing of mutagenized allele combinations
|
US11339427B2
(en)
|
2016-02-12 |
2022-05-24 |
Jumpcode Genomics, Inc. |
Method for target specific RNA transcription of DNA sequences
|
US9896696B2
(en)
|
2016-02-15 |
2018-02-20 |
Benson Hill Biosystems, Inc. |
Compositions and methods for modifying genomes
|
CN109476706A
(zh)
|
2016-02-16 |
2019-03-15 |
耶鲁大学 |
用于促进靶向基因编辑的组合物及其使用方法
|
WO2017143061A1
(en)
|
2016-02-16 |
2017-08-24 |
Yale University |
Compositions and methods for treatment of cystic fibrosis
|
WO2017143071A1
(en)
|
2016-02-18 |
2017-08-24 |
The Regents Of The University Of California |
Methods and compositions for gene editing in stem cells
|
EP3416689B1
(en)
|
2016-02-18 |
2023-01-18 |
CRISPR Therapeutics AG |
Materials and methods for treatment of severe combined immunodeficiency (scid) or omenn syndrome
|
US11155814B2
(en)
|
2016-02-22 |
2021-10-26 |
Caribou Biosciences, Inc. |
Methods for using DNA repair for cell engineering
|
CN105646719B
(zh)
*
|
2016-02-24 |
2019-12-20 |
无锡市妇幼保健院 |
一种高效定点转基因的工具及其应用
|
US11530253B2
(en)
|
2016-02-25 |
2022-12-20 |
The Children's Medical Center Corporation |
Customized class switch of immunoglobulin genes in lymphoma and hybridoma by CRISPR/CAS9 technology
|
DK3420089T3
(da)
*
|
2016-02-26 |
2022-03-14 |
Lanzatech Nz Inc |
CRISPR/Cas-systemer til C-1-fikserende bakterier
|
WO2017151444A1
(en)
|
2016-02-29 |
2017-09-08 |
Agilent Technologies, Inc. |
Methods and compositions for blocking off-target nucleic acids from cleavage by crispr proteins
|
EP3423083A4
(en)
|
2016-03-04 |
2019-10-02 |
Indoor Biotechnologies Inc. |
FEL D 1 INACTIVATIONS AND RELATED COMPOSITIONS AND METHODS BASED ON GENOMIC EDITION OF CRISPR-CAS9
|
EP3699281A1
(en)
|
2016-03-11 |
2020-08-26 |
Pioneer Hi-Bred International, Inc. |
Novel cas9 systems and methods of use
|
WO2017155715A1
(en)
|
2016-03-11 |
2017-09-14 |
Pioneer Hi-Bred International, Inc. |
Novel cas9 systems and methods of use
|
WO2017155717A1
(en)
|
2016-03-11 |
2017-09-14 |
Pioneer Hi-Bred International, Inc. |
Novel cas9 systems and methods of use
|
EP3429635A4
(en)
*
|
2016-03-15 |
2019-11-27 |
University of Massachusetts |
ANTI-CRISPR COMPOUNDS AND METHOD OF USE
|
WO2017158422A1
(en)
|
2016-03-16 |
2017-09-21 |
Crispr Therapeutics Ag |
Materials and methods for treatment of hereditary haemochromatosis
|
WO2017161043A1
(en)
|
2016-03-16 |
2017-09-21 |
The J. David Gladstone Institutes |
Methods and compositions for treating obesity and/or diabetes and for identifying candidate treatment agents
|
EP3219799A1
(en)
|
2016-03-17 |
2017-09-20 |
IMBA-Institut für Molekulare Biotechnologie GmbH |
Conditional crispr sgrna expression
|
WO2017165826A1
(en)
|
2016-03-25 |
2017-09-28 |
Editas Medicine, Inc. |
Genome editing systems comprising repair-modulating enzyme molecules and methods of their use
|
US11512311B2
(en)
|
2016-03-25 |
2022-11-29 |
Editas Medicine, Inc. |
Systems and methods for treating alpha 1-antitrypsin (A1AT) deficiency
|
WO2017172860A1
(en)
*
|
2016-03-31 |
2017-10-05 |
President And Fellows Of Harvard College |
Methods and compositions for the single tube preparation of sequencing libraries using cas9
|
WO2017173453A1
(en)
|
2016-04-01 |
2017-10-05 |
The Brigham And Women's Hospital, Inc. |
Stimuli-responsive nanoparticles for biomedical applications
|
EP3443086B1
(en)
|
2016-04-13 |
2021-11-24 |
Editas Medicine, Inc. |
Cas9 fusion molecules, gene editing systems, and methods of use thereof
|
WO2017180915A2
(en)
*
|
2016-04-13 |
2017-10-19 |
Duke University |
Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use
|
WO2017180926A1
(en)
*
|
2016-04-14 |
2017-10-19 |
Boco Silicon Valley. Inc. |
Genome editing of human neural stem cells using nucleases
|
AU2017250304B2
(en)
|
2016-04-15 |
2023-08-17 |
Novartis Ag |
Compositions and methods for selective protein expression
|
WO2017180989A2
(en)
|
2016-04-15 |
2017-10-19 |
Memorial Sloan Kettering Cancer Center |
Transgenic t cell and chimeric antigen receptor t cell compositions and related methods
|
WO2017181107A2
(en)
*
|
2016-04-16 |
2017-10-19 |
Ohio State Innovation Foundation |
Modified cpf1 mrna, modified guide rna, and uses thereof
|
DK3445388T3
(da)
|
2016-04-18 |
2024-06-03 |
Vertex Pharma |
Materialer og fremgangsmåder til behandling af hæmoglobinopatier
|
AU2017254718A1
(en)
*
|
2016-04-22 |
2018-11-15 |
Intellia Therapeutics, Inc. |
Compositions and methods for treatment of diseases associated with trinucleotide repeats in transcription factor four
|
CA3022290A1
(en)
|
2016-04-25 |
2017-11-02 |
President And Fellows Of Harvard College |
Hybridization chain reaction methods for in situ molecular detection
|
CN109072233A
(zh)
|
2016-04-26 |
2018-12-21 |
麻省理工学院 |
可扩展的重组酶级联
|
US11514331B2
(en)
|
2016-04-27 |
2022-11-29 |
Massachusetts Institute Of Technology |
Sequence-controlled polymer random access memory storage
|
EP3448997B1
(en)
|
2016-04-27 |
2020-10-14 |
Massachusetts Institute of Technology |
Stable nanoscale nucleic acid assemblies and methods thereof
|
WO2017191503A1
(en)
|
2016-05-05 |
2017-11-09 |
Crispr Therapeutics Ag |
Materials and methods for treatment of hemoglobinopathies
|
CN115837006A
(zh)
|
2016-05-06 |
2023-03-24 |
布里格姆及妇女医院股份有限公司 |
用于向软骨中受控递送被囊封的药剂的二元自组装凝胶
|
JP6872560B2
(ja)
*
|
2016-05-06 |
2021-05-19 |
エム. ウルフ、トッド |
プログラム可能ヌクレアーゼのあるゲノム編集及びプログラム可能ヌクレアーゼのないゲノム編集のための改善された方法
|
WO2017197128A1
(en)
|
2016-05-11 |
2017-11-16 |
Yale University |
Poly(amine-co-ester) nanoparticles and methods of use thereof
|
EP3456825A4
(en)
*
|
2016-05-13 |
2020-03-18 |
Kaneka Corporation |
METHOD FOR PLANT GENE EDITING
|
CN109152343A
(zh)
|
2016-05-13 |
2019-01-04 |
株式会社钟化 |
转化植物的制备方法
|
US11499158B2
(en)
|
2016-05-13 |
2022-11-15 |
Kaneka Corporation |
Method for modifying plant
|
RU2745563C2
(ru)
|
2016-05-20 |
2021-03-29 |
Регенерон Фармасьютикалс, Инк. |
Способы преодоления иммунологической толерантности с использованием множества направляющих рнк
|
EP3464323B1
(en)
*
|
2016-05-27 |
2021-09-22 |
Aadigen, LLC |
Peptides and nanoparticles for intracellular delivery of genome-editing molecules
|
US11286493B2
(en)
|
2016-05-27 |
2022-03-29 |
The Regents Of The University Of California |
Methods and compositions for targeting RNA polymerases and non-coding RNA biogenesis to specific loci
|
BR112018074531B1
(pt)
*
|
2016-06-02 |
2021-01-19 |
Sigma-Aldrich Co. Llc |
composição que compreende um sistema de nuclease e seu uso, kit, método in vitro para aumentar a eficiência da modificação do genoma-alvo e método para detectar uma sequência cromossômica
|
GB201609811D0
(en)
|
2016-06-05 |
2016-07-20 |
Snipr Technologies Ltd |
Methods, cells, systems, arrays, RNA and kits
|
US10767175B2
(en)
|
2016-06-08 |
2020-09-08 |
Agilent Technologies, Inc. |
High specificity genome editing using chemically modified guide RNAs
|
WO2017222834A1
(en)
*
|
2016-06-10 |
2017-12-28 |
City Of Hope |
Compositions and methods for mitochondrial genome editing
|
AU2017286122A1
(en)
|
2016-06-14 |
2018-11-22 |
Pioneer Hi-Bred International, Inc. |
Use of Cpf1 endonuclease for plant genome modifications
|
US20190177710A1
(en)
*
|
2016-06-15 |
2019-06-13 |
Toolgen Incorporated |
Method For Screening Target Specific Nuclease Using Multi-Target System Of On-Target And Off-Target And Use Thereof
|
US10337051B2
(en)
|
2016-06-16 |
2019-07-02 |
The Regents Of The University Of California |
Methods and compositions for detecting a target RNA
|
WO2017219027A1
(en)
*
|
2016-06-17 |
2017-12-21 |
The Broad Institute Inc. |
Type vi crispr orthologs and systems
|
CA3018430A1
(en)
|
2016-06-20 |
2017-12-28 |
Pioneer Hi-Bred International, Inc. |
Novel cas systems and methods of use
|
US11293021B1
(en)
|
2016-06-23 |
2022-04-05 |
Inscripta, Inc. |
Automated cell processing methods, modules, instruments, and systems
|
ES2915562T3
(es)
|
2016-06-24 |
2022-06-23 |
Univ Colorado Regents |
Métodos para generar bibliotecas combinatorias con código de barras
|
EP3474849A4
(en)
|
2016-06-27 |
2020-07-29 |
The Broad Institute, Inc. |
COMPOSITIONS AND METHODS FOR DETECTION AND TREATMENT OF DIABETES
|
CA3029271A1
(en)
|
2016-06-28 |
2018-01-04 |
Cellectis |
Altering expression of gene products in plants through targeted insertion of nucleic acid sequences
|
EP3478828B1
(en)
|
2016-06-29 |
2024-09-04 |
CRISPR Therapeutics AG |
Materials and methods for treatment of friedreich ataxia and other related disorders
|
EP3478829A1
(en)
|
2016-06-29 |
2019-05-08 |
Crispr Therapeutics AG |
Materials and methods for treatment of myotonic dystrophy type 1 (dm1) and other related disorders
|
US11174469B2
(en)
|
2016-06-29 |
2021-11-16 |
Crispr Therapeutics Ag |
Materials and methods for treatment of Amyotrophic Lateral Sclerosis (ALS) and other related disorders
|
WO2018005793A1
(en)
|
2016-06-30 |
2018-01-04 |
Zymergen Inc. |
Methods for generating a glucose permease library and uses thereof
|
WO2018005655A2
(en)
|
2016-06-30 |
2018-01-04 |
Zymergen Inc. |
Methods for generating a bacterial hemoglobin library and uses thereof
|
CN118542952A
(zh)
|
2016-07-06 |
2024-08-27 |
沃泰克斯药物股份有限公司 |
用于治疗疼痛相关病症的材料和方法
|
US11801313B2
(en)
|
2016-07-06 |
2023-10-31 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of pain related disorders
|
WO2018007871A1
(en)
|
2016-07-08 |
2018-01-11 |
Crispr Therapeutics Ag |
Materials and methods for treatment of transthyretin amyloidosis
|
WO2018013932A1
(en)
|
2016-07-15 |
2018-01-18 |
Salk Institute For Biological Studies |
Methods and compositions for genome editing in non-dividing cells
|
SG11201900344YA
(en)
|
2016-07-15 |
2019-02-27 |
Novartis Ag |
Treatment and prevention of cytokine release syndrome using a chimeric antigen receptor in combination with a kinase inhibitor
|
US12214056B2
(en)
|
2016-07-19 |
2025-02-04 |
Duke University |
Therapeutic applications of CPF1-based genome editing
|
WO2018015444A1
(en)
|
2016-07-22 |
2018-01-25 |
Novozymes A/S |
Crispr-cas9 genome editing with multiple guide rnas in filamentous fungi
|
WO2018020323A2
(en)
|
2016-07-25 |
2018-02-01 |
Crispr Therapeutics Ag |
Materials and methods for treatment of fatty acid disorders
|
CN106191043B
(zh)
*
|
2016-07-26 |
2019-07-02 |
吉林大学 |
一种基因片段、载体pPlasmid-Clearance及应用
|
KR20240027874A
(ko)
|
2016-07-28 |
2024-03-04 |
리제너론 파마슈티칼스 인코포레이티드 |
Gpr156 변이체 및 이들의 용도
|
ES2965134T3
(es)
|
2016-07-29 |
2024-04-11 |
Regeneron Pharma |
Ratones que contienen mutaciones que resultan en la expresión de fibrilina-1 truncada en C
|
EP3494220A1
(en)
|
2016-08-02 |
2019-06-12 |
Editas Medicine, Inc. |
Compositions and methods for treating cep290 associated disease
|
EP3494215A1
(en)
|
2016-08-03 |
2019-06-12 |
President and Fellows of Harvard College |
Adenosine nucleobase editors and uses thereof
|
US11078481B1
(en)
|
2016-08-03 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for screening for cancer targets
|
JOP20170161A1
(ar)
|
2016-08-04 |
2019-01-30 |
Arrowhead Pharmaceuticals Inc |
عوامل RNAi للعدوى بفيروس التهاب الكبد ب
|
JP7201153B2
(ja)
|
2016-08-09 |
2023-01-10 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
プログラム可能cas9-リコンビナーゼ融合タンパク質およびその使用
|
KR101710026B1
(ko)
|
2016-08-10 |
2017-02-27 |
주식회사 무진메디 |
Cas9 단백질 및 가이드 RNA의 혼성체를 함유하는 나노 리포좀 전달체 조성물
|
WO2018031950A1
(en)
|
2016-08-12 |
2018-02-15 |
Caribou Biosciences, Inc. |
Protein engineering methods
|
EP3498846B1
(en)
|
2016-08-12 |
2024-11-06 |
Toolgen Incorporated |
Manipulated immunoregulatory element and immunity altered thereby
|
EP3500669A4
(en)
*
|
2016-08-16 |
2020-01-22 |
The Regents of the University of California |
METHOD FOR SEARCHING FOR LOW ABUNDANCE SEQUENCES BY HYBRIDIZATION (FLASH)
|
MA46018A
(fr)
*
|
2016-08-19 |
2019-06-26 |
Bluebird Bio Inc |
Activateurs d'édition du génome
|
EP3500675A4
(en)
|
2016-08-19 |
2020-01-29 |
Whitehead Institute for Biomedical Research |
Methods of editing dna methylation
|
CN109963945A
(zh)
*
|
2016-08-20 |
2019-07-02 |
阿维利诺美国实验室股份有限公司 |
单一向导rna、crispr/cas9系统及其使用方法
|
WO2018039438A1
(en)
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
EP3503927A1
(en)
|
2016-08-29 |
2019-07-03 |
The Regents of the University of California |
Topical formulations based on ionic species for skin treatment
|
US11078483B1
(en)
|
2016-09-02 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for measuring and improving CRISPR reagent function
|
CN106399311A
(zh)
*
|
2016-09-07 |
2017-02-15 |
同济大学 |
用于Chip‑seq全基因组结合谱的内源蛋白标记的方法
|
EP3510407A1
(en)
|
2016-09-08 |
2019-07-17 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for diagnosing and treating nephrotic syndrome
|
WO2018049168A1
(en)
|
2016-09-09 |
2018-03-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
High-throughput precision genome editing
|
EP3512535A4
(en)
|
2016-09-13 |
2020-05-06 |
The Jackson Laboratory |
Targeted enhanced dna demethylation
|
EA201990591A1
(ru)
|
2016-09-23 |
2019-08-30 |
Фред Хатчинсон Кэнсер Рисерч Сентер |
Tcr, специфичные к минорному антигену гистосовместимости (h) ha-1, и их применения
|
US20190225974A1
(en)
|
2016-09-23 |
2019-07-25 |
BASF Agricultural Solutions Seed US LLC |
Targeted genome optimization in plants
|
JP2019532672A
(ja)
|
2016-09-28 |
2019-11-14 |
ノバルティス アーゲー |
多孔質膜系巨大分子送達システム
|
WO2018060238A1
(en)
*
|
2016-09-29 |
2018-04-05 |
F. Hoffmann-La Roche Ag |
Method to analyze and optimize gene editing modules and delivery approaches
|
GB201616590D0
(en)
*
|
2016-09-29 |
2016-11-16 |
Oxford Nanopore Technologies Limited |
Method
|
EP3523426A4
(en)
|
2016-09-30 |
2020-01-22 |
The Regents of The University of California |
RNA GUIDED NUCLEIC ACID MODIFYING ENZYMES AND METHOD FOR USE THEREOF
|
CN110418647B
(zh)
*
|
2016-09-30 |
2024-10-29 |
加利福尼亚大学董事会 |
Rna指导的核酸修饰酶及其使用方法
|
US10669539B2
(en)
|
2016-10-06 |
2020-06-02 |
Pioneer Biolabs, Llc |
Methods and compositions for generating CRISPR guide RNA libraries
|
KR102717188B1
(ko)
|
2016-10-07 |
2024-10-16 |
노파르티스 아게 |
암의 치료를 위한 키메라 항원 수용체
|
WO2018069232A1
(en)
|
2016-10-10 |
2018-04-19 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for predicting the risk of having cardiac hypertrophy
|
WO2018071448A1
(en)
|
2016-10-11 |
2018-04-19 |
The Regents Of The University Of California |
Systems and methods to encapsulate and preserve organic matter for analysis
|
CA3037560A1
(en)
|
2016-10-13 |
2018-04-19 |
Pioneer Hi-Bred International, Inc. |
Generating northern leaf blight resistant maize
|
KR102662249B1
(ko)
|
2016-10-14 |
2024-05-03 |
더 제너럴 하스피탈 코포레이션 |
후성적으로 조절되는 부위-특이적 뉴클레아제
|
KR102622411B1
(ko)
|
2016-10-14 |
2024-01-10 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵염기 에디터의 aav 전달
|
GB201617559D0
(en)
|
2016-10-17 |
2016-11-30 |
University Court Of The University Of Edinburgh The |
Swine comprising modified cd163 and associated methods
|
CN110520530A
(zh)
|
2016-10-18 |
2019-11-29 |
明尼苏达大学董事会 |
肿瘤浸润性淋巴细胞和治疗方法
|
WO2018081138A1
(en)
|
2016-10-24 |
2018-05-03 |
Yale University |
Biodegradable contraceptive implants
|
WO2018081531A2
(en)
|
2016-10-28 |
2018-05-03 |
Ariad Pharmaceuticals, Inc. |
Methods for human t-cell activation
|
WO2018080573A1
(en)
|
2016-10-28 |
2018-05-03 |
Massachusetts Institute Of Technology |
Crispr/cas global regulator screening platform
|
EP3535396A1
(en)
|
2016-11-01 |
2019-09-11 |
Novartis AG |
Methods and compositions for enhancing gene editing
|
WO2018085414A1
(en)
*
|
2016-11-02 |
2018-05-11 |
President And Fellows Of Harvard College |
Engineered guide rna sequences for in situ detection and sequencing
|
CN109689693B
(zh)
*
|
2016-11-03 |
2022-06-28 |
深圳华大生命科学研究院 |
提高基因编辑效率的方法和系统
|
WO2018144097A1
(en)
|
2016-11-04 |
2018-08-09 |
Akeagen Llc |
Genetically modified non-human animals and methods for producing heavy chain-only antibodies
|
WO2018085693A1
(en)
|
2016-11-04 |
2018-05-11 |
Inari Agriculture, Inc. |
Novel plant cells, plants, and seeds
|
US20190345500A1
(en)
|
2016-11-14 |
2019-11-14 |
|Nserm (Institut National De La Santé Et De La Recherche Médicale) |
Methods and pharmaceutical compositions for modulating stem cells proliferation or differentiation
|
WO2018094356A2
(en)
*
|
2016-11-18 |
2018-05-24 |
Genedit Inc. |
Compositions and methods for target nucleic acid modification
|
KR20190085528A
(ko)
|
2016-11-22 |
2019-07-18 |
싱가포르국립대학교 |
T 세포 악성종양의 면역요법을 위한 키메라 항원 수용체 및 cd7 발현의 차단
|
EP3545090A1
(en)
|
2016-11-28 |
2019-10-02 |
The Board of Regents of The University of Texas System |
Prevention of muscular dystrophy by crispr/cpf1-mediated gene editing
|
WO2018100190A1
(en)
|
2016-12-02 |
2018-06-07 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and compositions for diagnosing renal cell carcinoma
|
US9816093B1
(en)
|
2016-12-06 |
2017-11-14 |
Caribou Biosciences, Inc. |
Engineered nucleic acid-targeting nucleic acids
|
JP2020500541A
(ja)
|
2016-12-08 |
2020-01-16 |
ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム |
ヒト化デュシェンヌ型筋ジストロフィー変異を有するdmdレポーターモデル
|
JP7206214B2
(ja)
|
2016-12-13 |
2023-01-17 |
シアトル チルドレンズ ホスピタル (ディービーエイ シアトル チルドレンズ リサーチ インスティテュート) |
インビトロ及びインビボで操作された細胞において発現された化学誘導シグナル伝達複合体の外因性薬物活性化の方法
|
BR112019012155A2
(pt)
|
2016-12-14 |
2019-11-12 |
Stichting Technische Wetenschappen |
uso de pelo menos uma molécula-guia de rna e uma proteína cas, método de ligação, clivagem, marcação ou modificação de um polinucleotídeo alvo de fita dupla, célula transformada, e, complexo de nucleoproteína
|
CN110582302A
(zh)
|
2016-12-14 |
2019-12-17 |
利甘达尔股份有限公司 |
用于核酸和/或蛋白有效负载递送的组合物和方法
|
WO2018112470A1
(en)
|
2016-12-16 |
2018-06-21 |
The Brigham And Women's Hospital, Inc. |
Co-delivery of nucleic acids for simultaneous suppression and expression of target genes
|
WO2018118585A1
(en)
*
|
2016-12-22 |
2018-06-28 |
Agenovir Corporation |
Antiviral compositions
|
US10745677B2
(en)
|
2016-12-23 |
2020-08-18 |
President And Fellows Of Harvard College |
Editing of CCR5 receptor gene to protect against HIV infection
|
WO2018126087A1
(en)
|
2016-12-29 |
2018-07-05 |
Applied Stemcell, Inc. |
Gene editing method using virus
|
EP3342868B1
(en)
|
2016-12-30 |
2019-12-25 |
Systasy Bioscience GmbH |
Constructs and screening methods
|
US11859219B1
(en)
|
2016-12-30 |
2024-01-02 |
Flagship Pioneering Innovations V, Inc. |
Methods of altering a target nucleotide sequence with an RNA-guided nuclease and a single guide RNA
|
US12065666B2
(en)
|
2017-01-05 |
2024-08-20 |
Rutgers, The State University Of New Jersey |
Targeted gene editing platform independent of DNA double strand break and uses thereof
|
JOP20190166A1
(ar)
|
2017-01-05 |
2019-07-02 |
Univ Texas |
استراتيجية مثلى من أجل تعديلات تخطي إكسون باستخدام crispr/cas9 مع متواليات توجيه ثلاثي
|
WO2018127585A1
(en)
|
2017-01-06 |
2018-07-12 |
Txcell |
Monospecific regulatory t cell population with cytotoxicity for b cells
|
EP3346001A1
(en)
|
2017-01-06 |
2018-07-11 |
TXCell |
Monospecific regulatory t cell population with cytotoxicity for b cells
|
JP7229923B2
(ja)
|
2017-01-06 |
2023-02-28 |
エディタス・メディシン、インコーポレイテッド |
ヌクレアーゼ切断を評価する方法
|
DK3565891T3
(da)
|
2017-01-09 |
2023-07-24 |
Whitehead Inst Biomedical Res |
Fremgangsmåder til ændring af genekspression ved forstyrrelse af transkriptionsfaktor-multimere, der strukturerer regulatoriske sløjfer
|
US11230710B2
(en)
|
2017-01-09 |
2022-01-25 |
Aposense Ltd |
Compounds and methods for trans-membrane delivery of molecules
|
EP3568470B1
(en)
|
2017-01-10 |
2022-07-06 |
Christiana Care Health Services, Inc. |
Methods for in vitro site-directed mutagenesis using gene editing technologies
|
WO2018131551A1
(ja)
*
|
2017-01-13 |
2018-07-19 |
学校法人自治医科大学 |
肝臓ゲノム上の凝固関連因子遺伝子を破壊するためのaavベクター
|
AU2018209969B2
(en)
|
2017-01-20 |
2024-02-29 |
The Regents Of The University Of California |
Targeted gene activation in plants
|
RU2021133626A
(ru)
*
|
2017-01-23 |
2022-01-31 |
Регенерон Фармасьютикалз, Инк. |
Варианты hsd17b13 и их применения
|
US11566253B2
(en)
|
2017-01-26 |
2023-01-31 |
The Regents Of The University Of California |
Targeted gene demethylation in plants
|
EP3574005B1
(en)
|
2017-01-26 |
2021-12-15 |
Novartis AG |
Cd28 compositions and methods for chimeric antigen receptor therapy
|
WO2018140899A1
(en)
|
2017-01-28 |
2018-08-02 |
Inari Agriculture, Inc. |
Novel plant cells, plants, and seeds
|
US20190375815A1
(en)
|
2017-01-31 |
2019-12-12 |
Novartis Ag |
Treatment of cancer using chimeric t cell receptor proteins having multiple specificities
|
JP2020506702A
(ja)
|
2017-02-02 |
2020-03-05 |
カーギル インコーポレイテッド |
C6−c10脂肪酸誘導体を生成する遺伝子組み換え細胞
|
WO2018203947A2
(en)
|
2017-02-06 |
2018-11-08 |
Zymergen Inc. |
Engineered biosynthetic pathways for production of tyramine by fermentation
|
US10995333B2
(en)
*
|
2017-02-06 |
2021-05-04 |
10X Genomics, Inc. |
Systems and methods for nucleic acid preparation
|
TW201839136A
(zh)
|
2017-02-06 |
2018-11-01 |
瑞士商諾華公司 |
治療血色素異常症之組合物及方法
|
US11311609B2
(en)
|
2017-02-08 |
2022-04-26 |
Dana-Farber Cancer Institute, Inc. |
Regulating chimeric antigen receptors
|
EP3579872A1
(en)
|
2017-02-10 |
2019-12-18 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the mapk pathway
|
KR20190116282A
(ko)
|
2017-02-10 |
2019-10-14 |
지머젠 인코포레이티드 |
복수의 숙주를 위한 다중 dna 구조체의 조립 및 편집을 위한 모듈식 범용 플라스미드 디자인 전략
|
EP3585878A4
(en)
|
2017-02-21 |
2020-12-09 |
Duke University |
COMPOSITIONS AND PROCESSES FOR ROBUST DYNAMIC METABOLIC REGULATION
|
EP3585900B1
(en)
|
2017-02-22 |
2022-12-21 |
CRISPR Therapeutics AG |
Materials and methods for treatment of spinocerebellar ataxia type 2 (sca2) and other spinocerebellar ataxia type 2 protein (atxn2) gene related conditions or disorders
|
EP3585898A1
(en)
|
2017-02-22 |
2020-01-01 |
CRISPR Therapeutics AG |
Materials and methods for treatment of spinocerebellar ataxia type 1 (sca1) and other spinocerebellar ataxia type 1 protein (atxn1) gene related conditions or disorders
|
US11407997B2
(en)
|
2017-02-22 |
2022-08-09 |
Crispr Therapeutics Ag |
Materials and methods for treatment of primary hyperoxaluria type 1 (PH1) and other alanine-glyoxylate aminotransferase (AGXT) gene related conditions or disorders
|
US11920148B2
(en)
|
2017-02-22 |
2024-03-05 |
Crispr Therapeutics Ag |
Compositions and methods for gene editing
|
US20200040061A1
(en)
|
2017-02-22 |
2020-02-06 |
Crispr Therapeutics Ag |
Materials and methods for treatment of early onset parkinson's disease (park1) and other synuclein, alpha (snca) gene related conditions or disorders
|
IL268895B1
(en)
|
2017-02-28 |
2025-01-01 |
Vor Biopharma Inc |
Compositions and methods for inhibiting proteins with specific binding
|
US20200048359A1
(en)
|
2017-02-28 |
2020-02-13 |
Novartis Ag |
Shp inhibitor compositions and uses for chimeric antigen receptor therapy
|
WO2018165504A1
(en)
|
2017-03-09 |
2018-09-13 |
President And Fellows Of Harvard College |
Suppression of pain by gene editing
|
EP3592777A1
(en)
|
2017-03-10 |
2020-01-15 |
President and Fellows of Harvard College |
Cytosine to guanine base editor
|
WO2018170184A1
(en)
|
2017-03-14 |
2018-09-20 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
EP3595694A4
(en)
*
|
2017-03-14 |
2021-06-09 |
The Regents of The University of California |
Engineering crispr cas9 immune stealth
|
CN110582299A
(zh)
|
2017-03-15 |
2019-12-17 |
弗雷德哈钦森癌症研究中心 |
高亲和力mage-a1特异性tcr及其用途
|
WO2018167119A1
(en)
|
2017-03-15 |
2018-09-20 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Pharmaceutical compositions for the treatment of thrombosis in patients suffering from a myeloproliferative neoplasm
|
AU2018240571B2
(en)
|
2017-03-23 |
2024-11-07 |
President And Fellows Of Harvard College |
Nucleobase editors comprising nucleic acid programmable DNA binding proteins
|
SG11201906297QA
(en)
*
|
2017-03-24 |
2019-10-30 |
Curevac Ag |
Nucleic acids encoding crispr-associated proteins and uses thereof
|
WO2018172508A1
(en)
|
2017-03-24 |
2018-09-27 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and compositions for treating melanoma
|
EP3600269A1
(en)
|
2017-03-24 |
2020-02-05 |
INSERM - Institut National de la Santé et de la Recherche Médicale |
Gfi1 inhibitors for the treatment of hyperglycemia
|
US10876101B2
(en)
|
2017-03-28 |
2020-12-29 |
Locanabio, Inc. |
CRISPR-associated (Cas) protein
|
WO2018183607A1
(en)
|
2017-03-30 |
2018-10-04 |
Pioneer Hi-Bred International, Inc. |
Methods of identifying and characterizing gene editing variations in nucleic acids
|
US20210275543A1
(en)
|
2017-03-30 |
2021-09-09 |
Nserm (Institut National De La Santé Et De La Recherche Médicale) |
Methods for the treatment of mitochondrial genetic diseases
|
US20200113821A1
(en)
|
2017-04-04 |
2020-04-16 |
Yale University |
Compositions and methods for in utero delivery
|
JP2020516283A
(ja)
|
2017-04-11 |
2020-06-11 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. |
ヒドロキシステロイド(17−ベータ)デヒドロゲナーゼ(hsd17b)ファミリーのメンバーのモジュレーターの活性をスクリーニングするためのアッセイ
|
US11913015B2
(en)
|
2017-04-17 |
2024-02-27 |
University Of Maryland, College Park |
Embryonic cell cultures and methods of using the same
|
US11834670B2
(en)
*
|
2017-04-19 |
2023-12-05 |
Global Life Sciences Solutions Usa Llc |
Site-specific DNA modification using a donor DNA repair template having tandem repeat sequences
|
KR20250007033A
(ko)
|
2017-04-20 |
2025-01-13 |
이제네시스, 인크. |
유전자 변형 동물의 생성 방법
|
US11458118B2
(en)
|
2017-04-21 |
2022-10-04 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for the treatment of diseases associated with reduced CFTR function
|
EP3612204A4
(en)
|
2017-04-21 |
2021-01-27 |
The General Hospital Corporation |
INDUCTIBLE, TUNING AND MULTIPLEX HUMAN GENE REGULATION USING CRISPR-CPF1
|
US11591589B2
(en)
|
2017-04-21 |
2023-02-28 |
The General Hospital Corporation |
Variants of Cpf1 (Cas12a) with altered PAM specificity
|
EP3615552A1
(en)
|
2017-04-24 |
2020-03-04 |
DuPont Nutrition Biosciences ApS |
Methods and compositions of anti-crispr proteins for use in plants
|
US20200179511A1
(en)
|
2017-04-28 |
2020-06-11 |
Novartis Ag |
Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor
|
WO2018201056A1
(en)
|
2017-04-28 |
2018-11-01 |
Novartis Ag |
Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor
|
EP3615672A1
(en)
|
2017-04-28 |
2020-03-04 |
Editas Medicine, Inc. |
Methods and systems for analyzing guide rna molecules
|
WO2018204722A1
(en)
*
|
2017-05-05 |
2018-11-08 |
Califorinia Institute Of Technology |
Dna sequence modification-based gene drive
|
WO2018202921A2
(en)
|
2017-05-05 |
2018-11-08 |
Universitat Autònoma De Barcelona |
Nanostructured proteins and uses thereof
|
CN110914431B
(zh)
*
|
2017-05-08 |
2024-04-19 |
株式会社图尔金 |
经人工操纵的免疫细胞
|
WO2018209158A2
(en)
|
2017-05-10 |
2018-11-15 |
Editas Medicine, Inc. |
Crispr/rna-guided nuclease systems and methods
|
MX2019013514A
(es)
|
2017-05-12 |
2020-01-20 |
Crispr Therapeutics Ag |
Materiales y metodos para modificar celulas por ingenieria genetica y usos de los mismos en inmunooncologia.
|
US11560566B2
(en)
|
2017-05-12 |
2023-01-24 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
|
WO2018213351A1
(en)
*
|
2017-05-16 |
2018-11-22 |
The Regents Of The University Of California |
Thermostable rna-guided endonucleases and methods of use thereof
|
WO2018212361A1
(en)
*
|
2017-05-17 |
2018-11-22 |
Edigene Corporation |
Method of treating diseases associated with myd88 pathways using crispr-gndm system
|
CA3062981A1
(en)
|
2017-05-17 |
2018-11-22 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Flt3 inhibitors for improving pain treatments by opioids
|
US10780119B2
(en)
|
2017-05-24 |
2020-09-22 |
Effector Therapeutics Inc. |
Methods and compositions for cellular immunotherapy
|
EP3630970A4
(en)
|
2017-05-25 |
2020-12-30 |
The General Hospital Corporation |
BASE EDITORS WITH IMPROVED PRECISION AND SPECIFICITY
|
US11788087B2
(en)
|
2017-05-25 |
2023-10-17 |
The Children's Medical Center Corporation |
BCL11A guide delivery
|
WO2018226560A1
(en)
|
2017-06-05 |
2018-12-13 |
Regeneron Pharmaceuticals, Inc. |
B4galt1 variants and uses thereof
|
CN108977442B
(zh)
*
|
2017-06-05 |
2023-01-06 |
广州市锐博生物科技有限公司 |
用于dna编辑的系统及其应用
|
WO2018226880A1
(en)
|
2017-06-06 |
2018-12-13 |
Zymergen Inc. |
A htp genomic engineering platform for improving escherichia coli
|
WO2018226900A2
(en)
|
2017-06-06 |
2018-12-13 |
Zymergen Inc. |
A htp genomic engineering platform for improving fungal strains
|
US20210079100A1
(en)
|
2017-06-08 |
2021-03-18 |
Inserm (Institute National De La Sante Et De La Recherche Medicale) |
Methods and compositions for treating hyperpigmentation disorders
|
WO2018227210A1
(en)
|
2017-06-09 |
2018-12-13 |
The Regents Of The University Of California |
High-efficiency encapsulation in droplets based on hydrodynamic vortices control
|
US11517901B2
(en)
|
2017-06-09 |
2022-12-06 |
The Regents Of The University Of California |
High-efficiency particle encapsulation in droplets with particle spacing and downstream droplet sorting
|
CN110997908A
(zh)
|
2017-06-09 |
2020-04-10 |
爱迪塔斯医药公司 |
工程化的cas9核酸酶
|
CA3066750A1
(en)
|
2017-06-13 |
2018-12-20 |
Flagship Pioneering Innovations V, Inc. |
Compositions comprising curons and uses thereof
|
MX2019015188A
(es)
|
2017-06-15 |
2020-08-03 |
Univ California |
Inserciones de adn no virales orientadas.
|
AU2018289077B2
(en)
|
2017-06-23 |
2022-03-10 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
US10011849B1
(en)
|
2017-06-23 |
2018-07-03 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
US9982279B1
(en)
|
2017-06-23 |
2018-05-29 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
US20230193241A1
(en)
|
2017-06-25 |
2023-06-22 |
Snipr Technologies Limited |
Altering microbial populations & modifying microbiota
|
CN118109477A
(zh)
|
2017-06-27 |
2024-05-31 |
瑞泽恩制药公司 |
包含人源化asgr1基因座的非人动物
|
EP4270012A3
(en)
|
2017-06-30 |
2024-04-03 |
Inscripta, Inc. |
Automated cell processing methods, modules, instruments and systems
|
WO2019005539A1
(en)
|
2017-06-30 |
2019-01-03 |
Codexis, Inc. |
T7 POLYMERASE RNA VARIANTS
|
US11168322B2
(en)
|
2017-06-30 |
2021-11-09 |
Arbor Biotechnologies, Inc. |
CRISPR RNA targeting enzymes and systems and uses thereof
|
EP3645721A1
(en)
|
2017-06-30 |
2020-05-06 |
Novartis AG |
Methods for the treatment of disease with gene editing systems
|
KR20200023455A
(ko)
|
2017-06-30 |
2020-03-04 |
코덱시스, 인코포레이티드 |
T7 rna 폴리머라제 변이체
|
EP3645021A4
(en)
|
2017-06-30 |
2021-04-21 |
Intima Bioscience, Inc. |
ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY
|
MA49578A
(fr)
|
2017-07-11 |
2021-04-07 |
Synthorx Inc |
Incorporation de nucléotides non naturels et procédés associés
|
EP3427756A1
(en)
|
2017-07-14 |
2019-01-16 |
Universidad Autónoma De Barcelona (UAB) |
Therapeutic nanoconjugates and uses thereof
|
WO2019014564A1
(en)
|
2017-07-14 |
2019-01-17 |
Editas Medicine, Inc. |
SYSTEMS AND METHODS OF TARGETED INTEGRATION AND GENOME EDITING AND DETECTION THEREOF WITH INTEGRATED PRIMING SITES
|
US11452967B2
(en)
|
2017-07-17 |
2022-09-27 |
Zymergen Inc. |
Metal-organic framework materials
|
WO2019018551A2
(en)
|
2017-07-18 |
2019-01-24 |
Lee Tzumin |
METHODS AND COMPOSITIONS FOR GENETICALLY GENETIC HANDLING OF GENES AND CELLS
|
WO2019016310A1
(en)
|
2017-07-20 |
2019-01-24 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
METHODS AND COMPOSITIONS FOR TREATING CANCERS
|
US11926664B2
(en)
|
2017-07-25 |
2024-03-12 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for modulating monocytopoiesis
|
CN109295054B
(zh)
*
|
2017-07-25 |
2024-02-06 |
广州普世利华科技有限公司 |
用于靶向病原体基因RNA的gRNA及基于C2c2的病原体基因的检测方法及试剂盒
|
EP3658573A1
(en)
|
2017-07-28 |
2020-06-03 |
President and Fellows of Harvard College |
Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace)
|
KR20200032117A
(ko)
|
2017-07-31 |
2020-03-25 |
리제너론 파마슈티칼스 인코포레이티드 |
생체 내에서 외인성 공여체 핵산과의 CRISPR/Cas-유도된 재조합의 평가
|
KR20200036912A
(ko)
|
2017-07-31 |
2020-04-07 |
리플렉션 바이오테크놀러지스 리미티드 |
안과 질환을 위한 세포 모델 및 치료요법
|
EP3585159A1
(en)
|
2017-07-31 |
2020-01-01 |
Regeneron Pharmaceuticals, Inc. |
Cas-transgenic mouse embryonic stem cells and mice and uses thereof
|
MX2020001177A
(es)
|
2017-07-31 |
2020-09-25 |
Regeneron Pharma |
Animales no humanos reporteros de crispr y usos de los mismos.
|
CN111278848B
(zh)
|
2017-08-04 |
2023-06-27 |
北京大学 |
特异性识别甲基化修饰dna碱基的tale rvd及其应用
|
WO2019028686A1
(zh)
|
2017-08-08 |
2019-02-14 |
北京大学 |
基因敲除方法
|
US11384383B2
(en)
|
2017-08-08 |
2022-07-12 |
Depixus |
In vitro isolation and enrichment of nucleic acids using site-specific nucleases
|
JP7355730B2
(ja)
|
2017-08-09 |
2023-10-03 |
ベンソン ヒル,インコーポレイティド |
ゲノムを修飾するための組成物及び方法
|
EP3668983A1
(en)
*
|
2017-08-18 |
2020-06-24 |
The Board of Regents of The University of Texas System |
Exon deletion correction of duchenne muscular dystrophy mutations in the dystrophin actin binding domain 1 using crispr genome editing
|
EP3673054A4
(en)
*
|
2017-08-22 |
2021-06-02 |
Napigen, Inc. |
ORGANEL GENOME MODIFICATION USING POLYNUCLEOTIDE-GUIDED ENDONUCLEASE
|
CN118530967A
(zh)
|
2017-08-23 |
2024-08-23 |
通用医疗公司 |
具有改变的PAM特异性的工程化的CRISPR-Cas9核酸酶
|
US10738327B2
(en)
|
2017-08-28 |
2020-08-11 |
Inscripta, Inc. |
Electroporation cuvettes for automation
|
EP3676376B1
(en)
|
2017-08-30 |
2025-01-15 |
President and Fellows of Harvard College |
High efficiency base editors comprising gam
|
WO2019050948A1
(en)
*
|
2017-09-05 |
2019-03-14 |
Regeneron Pharmaceuticals, Inc. |
ADMINISTRATION OF A GENE EDITION SYSTEM HAVING ONLY ONE RETROVIRAL PARTICLE AND METHODS OF GENERATING AND USING
|
JP2020533289A
(ja)
|
2017-09-06 |
2020-11-19 |
フレッド ハッチンソン キャンサー リサーチ センター |
養子細胞治療を改善するための方法
|
EP3679072A1
(en)
|
2017-09-06 |
2020-07-15 |
Fred Hutchinson Cancer Research Center |
Strep-tag specific chimeric receptors and uses thereof
|
WO2019050899A1
(en)
|
2017-09-06 |
2019-03-14 |
Regeneron Pharmaceuticals, Inc. |
SINGLE IMMUNOGLOBULIN INTERLEUKIN 1 (SIGIRR) RELATED INTERCEPTOR-RELATED VARIANTS AND USES THEREOF
|
US20190071683A1
(en)
|
2017-09-07 |
2019-03-07 |
Regeneron Pharmaceuticals, Inc. |
Solute Carrier Family 14 Member 1 (SLC14A1) Variants And Uses Thereof
|
WO2019051097A1
(en)
|
2017-09-08 |
2019-03-14 |
The Regents Of The University Of California |
RNA-GUIDED ENDONUCLEASE FUSION POLYPEPTIDES AND METHODS OF USING SAME
|
AU2018329745A1
(en)
*
|
2017-09-11 |
2020-04-16 |
The Regents Of The University Of California |
Antibody-mediated delivery of Cas9 to mammalian cells
|
CN110168093B
(zh)
*
|
2017-09-12 |
2023-08-15 |
中科蓝华(广州)生物医药技术有限公司 |
一种转染细胞内寄生虫的试剂盒及其应用
|
WO2019055862A1
(en)
|
2017-09-14 |
2019-03-21 |
Fred Hutchinson Cancer Research Center |
HIGH AFFINITY T CELL RECEPTORS AND USES THEREOF
|
EP3684914B1
(en)
|
2017-09-18 |
2024-05-29 |
Futuragene Israel Ltd. |
Tissue-specific expression control of della polypeptides
|
TW201920661A
(zh)
|
2017-09-18 |
2019-06-01 |
大陸商博雅輯因(北京)生物科技有限公司 |
一種基因編輯t細胞及其用途
|
US20190218532A1
(en)
*
|
2017-09-19 |
2019-07-18 |
Massachusetts Institute Of Technology |
Streptococcus Canis Cas9 as a Genome Engineering Platform with Novel PAM Specificity
|
WO2019057649A1
(en)
|
2017-09-19 |
2019-03-28 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA
|
US11453865B2
(en)
*
|
2017-09-19 |
2022-09-27 |
Massachusetts Institute Of Technology |
Applications of engineered Streptococcus canis Cas9 variants on single-base PAM targets
|
BR112020005361A2
(pt)
|
2017-09-19 |
2020-09-24 |
The University Of British Columbia |
anticorpos anti-hla-a2 e métodos de uso dos mesmos
|
MX2020003100A
(es)
|
2017-09-19 |
2020-08-20 |
Advaxis Inc |
Composiciones y metodos para la liofilizacion de bacterias o cepas de listeria.
|
IT201700105372A1
(it)
*
|
2017-09-20 |
2019-03-20 |
Fondazione St Italiano Tecnologia |
Molecola di acido nucleico funzionale e relativo uso
|
US20200268837A1
(en)
|
2017-09-20 |
2020-08-27 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for modulating autophagy
|
JP7317023B2
(ja)
|
2017-09-20 |
2023-07-28 |
ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア |
新規抗hla-a2抗体、およびその使用
|
BR112020005803A2
(pt)
|
2017-09-25 |
2020-12-01 |
Agrospheres, Inc. |
composições e métodos para produção e administração moduláveis de produtos biológicos
|
US11572574B2
(en)
*
|
2017-09-28 |
2023-02-07 |
Toolgen Incorporated |
Artificial genome manipulation for gene expression regulation
|
KR20200058508A
(ko)
*
|
2017-09-29 |
2020-05-27 |
인텔리아 테라퓨틱스, 인크. |
게놈 편집을 위한 폴리뉴클레오티드, 조성물 및 방법
|
KR102662879B1
(ko)
*
|
2017-09-29 |
2024-05-02 |
주식회사 툴젠 |
망막 기능장애 질환 치료를 위한 유전자 조작
|
SG11202000771UA
(en)
|
2017-09-29 |
2020-04-29 |
Regeneron Pharma |
Non-human animals comprising a humanized ttr locus and methods of use
|
US10435713B2
(en)
|
2017-09-30 |
2019-10-08 |
Inscripta, Inc. |
Flow through electroporation instrumentation
|
CA3078247A1
(en)
|
2017-10-06 |
2019-04-11 |
Camp4 Therapeutics Corporation |
Methods and compositions for treating urea cycle disorders, in particular otc deficiency
|
US11725228B2
(en)
|
2017-10-11 |
2023-08-15 |
The General Hospital Corporation |
Methods for detecting site-specific and spurious genomic deamination induced by base editing technologies
|
CA3078883A1
(en)
|
2017-10-11 |
2019-04-18 |
Regeneron Pharmaceuticals, Inc. |
Inhibition of hsd17b13 in the treatment of liver disease in patients expressing the pnpla3 i148m variation
|
WO2019075409A1
(en)
|
2017-10-12 |
2019-04-18 |
The Regents Of The University Of California |
ISOLATION AND IDENTIFICATION WITHOUT MICROFLUIDIC LABEL OF CELLS USING FLUORESCENCE LIFE IMAGING (FLIM)
|
SG11202002822XA
(en)
|
2017-10-16 |
2020-04-29 |
Regeneron Pharma |
Cornulin (crnn) variants and uses thereof
|
US11795443B2
(en)
|
2017-10-16 |
2023-10-24 |
The Broad Institute, Inc. |
Uses of adenosine base editors
|
US20190247517A1
(en)
|
2017-10-17 |
2019-08-15 |
Casebia Therapeutics Limited Liability Partnership |
Compositions and methods for gene editing for hemophilia a
|
US11745179B2
(en)
*
|
2017-10-20 |
2023-09-05 |
The Regents Of The University Of California |
Microfluidic systems and methods for lipoplex-mediated cell transfection
|
US11499127B2
(en)
|
2017-10-20 |
2022-11-15 |
The Regents Of The University Of California |
Multi-layered microfluidic systems for in vitro large-scale perfused capillary networks
|
JP2021502330A
(ja)
|
2017-10-20 |
2021-01-28 |
フレッド ハッチンソン キャンサー リサーチ センター |
Tigitおよび/またはcd112rを標的とするか、またはcd226過剰発現を含む、組成物および免疫治療の方法
|
WO2019135816A2
(en)
*
|
2017-10-23 |
2019-07-11 |
The Broad Institute, Inc. |
Novel nucleic acid modifiers
|
EP3700535A1
(en)
|
2017-10-23 |
2020-09-02 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Compounds for treating cmv related diseases
|
KR102013798B1
(ko)
|
2017-10-25 |
2019-08-23 |
성균관대학교산학협력단 |
노화 모델 제조 방법 및 이에 의해 제조된 세포 또는 동물 노화 모델
|
MA50849A
(fr)
|
2017-10-26 |
2020-09-02 |
Vertex Pharma |
Substances et procédés pour le traitement d'hémoglobinopathies
|
KR102503130B1
(ko)
|
2017-10-27 |
2023-02-24 |
더 리전트 오브 더 유니버시티 오브 캘리포니아 |
내인성 t 세포 수용체의 표적화된 대체
|
CN109722415B
(zh)
|
2017-10-27 |
2021-01-26 |
博雅辑因(北京)生物科技有限公司 |
一种造血干细胞的培养组合物、培养基以及造血干细胞的培养方法
|
WO2019089798A1
(en)
|
2017-10-31 |
2019-05-09 |
Novartis Ag |
Anti-car compositions and methods
|
WO2019089808A1
(en)
|
2017-11-01 |
2019-05-09 |
The Regents Of The University Of California |
Class 2 crispr/cas compositions and methods of use
|
CN117487776A
(zh)
|
2017-11-01 |
2024-02-02 |
加利福尼亚大学董事会 |
Casz组合物和使用方法
|
WO2019087113A1
(en)
|
2017-11-01 |
2019-05-09 |
Novartis Ag |
Synthetic rnas and methods of use
|
EP3704237A1
(en)
*
|
2017-11-02 |
2020-09-09 |
Arbor Biotechnologies, Inc. |
Novel crispr-associated transposon systems and components
|
EP3707155A2
(en)
|
2017-11-09 |
2020-09-16 |
Vertex Pharmaceuticals Incorporated |
Crispr/cas systems for treatment of dmd
|
EP3707252A1
(en)
*
|
2017-11-10 |
2020-09-16 |
Novozymes A/S |
Temperature-sensitive cas9 protein
|
AU2018366290B2
(en)
|
2017-11-10 |
2022-01-27 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising Slc30a8 mutation and methods of use
|
WO2019094928A1
(en)
|
2017-11-10 |
2019-05-16 |
Massachusetts Institute Of Technology |
Microbial production of pure single stranded nucleic acids
|
US20210180059A1
(en)
|
2017-11-16 |
2021-06-17 |
Astrazeneca Ab |
Compositions and methods for improving the efficacy of cas9-based knock-in strategies
|
EP3713644B1
(en)
|
2017-11-20 |
2024-08-07 |
University of Georgia Research Foundation, Inc. |
Compositions and methods for modulating hif-2a to improve muscle generation and repair
|
WO2019101995A1
(en)
|
2017-11-27 |
2019-05-31 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for cardiac regeneration
|
ES2973937T3
(es)
|
2017-11-30 |
2024-06-25 |
Regeneron Pharma |
Ratas que comprenden un locus TRKB humanizado
|
US20220267403A1
(en)
|
2017-12-01 |
2022-08-25 |
Fred Hutchinson Cancer Research Center |
Binding proteins specific for 5t4 and uses thereof
|
EP3720453B1
(en)
|
2017-12-05 |
2024-07-10 |
Caribou Biosciences, Inc. |
Modified lymphocytes
|
US12161674B2
(en)
|
2017-12-05 |
2024-12-10 |
Vertex Pharmaceuticals Incorporated |
CRISPR-CAS9 modified CD34+ human hematopoietic stem and progenitor cells and uses thereof
|
CN111918960B
(zh)
*
|
2017-12-05 |
2025-01-28 |
比奥普来克斯有限公司 |
预防微生物感染的方法和组合物
|
WO2019113387A1
(en)
|
2017-12-07 |
2019-06-13 |
Zymergen Inc. |
Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation
|
CA3082956A1
(en)
|
2017-12-08 |
2019-06-13 |
Synthetic Genomics, Inc. |
Improving algal lipid productivity via genetic modification of a tpr domain containing protein
|
US11661599B1
(en)
|
2017-12-14 |
2023-05-30 |
National Technology & Engineering Solutions Of Sandia, Llc |
CRISPR-Cas based system for targeting single-stranded sequences
|
CA3084825A1
(en)
*
|
2017-12-14 |
2019-06-20 |
Crispr Therapeutics Ag |
Novel rna-programmable endonuclease systems and their use in genome editing and other applications
|
CN111465689B
(zh)
|
2017-12-15 |
2024-07-12 |
丹尼斯科美国公司 |
Cas9变体和使用方法
|
AU2018385757B2
(en)
|
2017-12-15 |
2023-10-19 |
Flagship Pioneering Innovations Vi, Llc |
Compositions comprising circular polyribonucleotides and uses thereof
|
CN111836892A
(zh)
|
2017-12-21 |
2020-10-27 |
克里斯珀医疗股份公司 |
用于治疗2a型乌谢尔综合征的材料和方法
|
SG11202006101WA
(en)
*
|
2017-12-29 |
2020-07-29 |
Scripps Research Inst |
Unnatural base pair compositions and methods of use
|
US11193132B2
(en)
|
2017-12-29 |
2021-12-07 |
Synthetic Genomics, Inc. |
Genetic modulation of photosynthetic organisms for improved growth
|
US20190201548A1
(en)
|
2017-12-29 |
2019-07-04 |
Rubius Therapeutics, Inc. |
Gene editing and targeted transcriptional modulation for engineering erythroid cells
|
EP3735590A1
(en)
|
2018-01-04 |
2020-11-11 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and compositions for treating melanoma resistant
|
WO2019136216A1
(en)
|
2018-01-05 |
2019-07-11 |
The Board Of Regents Of The University Of Texas System |
Therapeutic crispr/cas9 compositions and methods of use
|
EP3737766A4
(en)
|
2018-01-09 |
2021-11-24 |
Cibus US LLC |
GENES OF RESISTANCE TO CRUSHING AND MUTATIONS
|
WO2019140278A1
(en)
|
2018-01-11 |
2019-07-18 |
Fred Hutchinson Cancer Research Center |
Immunotherapy targeting core binding factor antigens
|
US11268092B2
(en)
|
2018-01-12 |
2022-03-08 |
GenEdit, Inc. |
Structure-engineered guide RNA
|
CA3088180A1
(en)
|
2018-01-12 |
2019-07-18 |
Crispr Therapeutics Ag |
Compositions and methods for gene editing by targeting transferrin
|
AU2019207409B2
(en)
|
2018-01-12 |
2023-02-23 |
Basf Se |
Gene underlying the number of spikelets per spike qtl in wheat on chromosome 7a
|
IL276082B2
(en)
*
|
2018-01-17 |
2024-01-01 |
Vertex Pharma |
Dna-pk inhibitor compounds, compositions comprising same and uses thereof
|
US12145984B2
(en)
|
2018-01-24 |
2024-11-19 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Methods for preventing ischemia reperfusion injury in an organ with antibody antagonists of IL-33
|
WO2019147275A1
(en)
*
|
2018-01-26 |
2019-08-01 |
Integrated Dna Technologies, Inc. |
Crispr-based compositions and methods of use
|
US12098363B2
(en)
*
|
2018-01-26 |
2024-09-24 |
The Children's Medical Center Corporation |
Targeting BCL11A distal regulatory elements with a CAS9-CAS9 fusion for fetal hemoglobin reinduction
|
US11926835B1
(en)
|
2018-01-29 |
2024-03-12 |
Inari Agriculture Technology, Inc. |
Methods for efficient tomato genome editing
|
JP2021511803A
(ja)
|
2018-01-31 |
2021-05-13 |
ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム |
ヒト心筋細胞におけるジストロフィン変異を修正するための組成物および方法
|
WO2019150309A1
(en)
|
2018-02-02 |
2019-08-08 |
Hammack Scott |
Modulators of gpr68 and uses thereof for treating and preventing diseases
|
MA51788A
(fr)
|
2018-02-05 |
2020-12-16 |
Vertex Pharma |
Substances et méthodes pour traiter des hémoglobinopathies
|
US20210093679A1
(en)
|
2018-02-05 |
2021-04-01 |
Novome Biotechnologies, Inc. |
Engineered gut microbes and uses thereof
|
EP3749767A1
(en)
|
2018-02-05 |
2020-12-16 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of hemoglobinopathies
|
WO2019157326A1
(en)
|
2018-02-08 |
2019-08-15 |
Zymergen Inc. |
Genome editing using crispr in corynebacterium
|
KR102465067B1
(ko)
*
|
2018-02-15 |
2022-11-10 |
시그마-알드리치 컴퍼니., 엘엘씨 |
진핵 게놈 변형을 위한 조작된 cas9 시스템
|
JP7384811B2
(ja)
|
2018-02-16 |
2023-11-21 |
アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル |
白斑を処置するための方法及び組成物
|
MA51869A
(fr)
|
2018-02-16 |
2020-12-23 |
Bayer Healthcare Llc |
Compositions et méthodes pour l'édition génique par ciblage du fibrinogène-alpha
|
EP3755798A4
(en)
|
2018-02-19 |
2022-04-06 |
Yale University |
PHOSPHOPEPTIDE-ENCODING OLIGONUCLEOTIDE LIBRARIES AND METHODS FOR DETECTING PHOSPHORYLATION-DEPENDENT MOLECULAR INTERACTIONS
|
CN112020554B
(zh)
|
2018-02-23 |
2024-10-22 |
先锋国际良种公司 |
新颖cas9直系同源物
|
CA3091138A1
(en)
|
2018-02-26 |
2019-08-29 |
Fred Hutchinson Cancer Research Center |
Compositions and methods for cellular immunotherapy
|
US11713472B2
(en)
|
2018-03-06 |
2023-08-01 |
The Board Of Trustees Of The University Of Illinois |
Genome editing in Archaea
|
AU2019231783B2
(en)
|
2018-03-09 |
2023-11-16 |
Advaxis, Inc. |
Compositions and methods for evaluating attenuation and infectivity of Listeria strains
|
US11332752B2
(en)
*
|
2018-03-12 |
2022-05-17 |
Pioneer Hi-Bred International, Inc. |
Use of morphogenic factors for the improvement of gene editing
|
CN112020558A
(zh)
|
2018-03-14 |
2020-12-01 |
爱迪塔斯医药公司 |
治疗血红蛋白病的系统和方法
|
EP3765094A4
(en)
|
2018-03-15 |
2021-12-22 |
KSQ Therapeutics, Inc. |
GENE REGULATION COMPOSITIONS AND METHODS FOR IMPROVING IMMUNOTHERAPY
|
KR20240038811A
(ko)
|
2018-03-19 |
2024-03-25 |
리제너론 파마슈티칼스 인코포레이티드 |
CRISPR/Cas 시스템을 사용한 동물에서의 전사 조절
|
JP7550648B2
(ja)
*
|
2018-03-19 |
2024-09-13 |
クリスパー セラピューティクス アーゲー |
新規rnaプログラム可能エンドヌクレアーゼ系およびその使用
|
EP3768836B1
(en)
|
2018-03-20 |
2023-12-20 |
Tsinghua University |
Alzheimer's disease animal model and use thereof
|
US10760075B2
(en)
|
2018-04-30 |
2020-09-01 |
Snipr Biome Aps |
Treating and preventing microbial infections
|
CN111148833B
(zh)
*
|
2018-03-26 |
2021-04-02 |
国立大学法人神户大学 |
改变细胞具有的双链dna的目标部位的方法
|
KR20210010853A
(ko)
*
|
2018-03-27 |
2021-01-28 |
(주)지플러스생명과학 |
서열 특이적인 생체내 세포 표적화
|
CN112204131A
(zh)
|
2018-03-29 |
2021-01-08 |
因思科瑞普特公司 |
用于诱导和转化的细胞生长速率的自动化控制
|
WO2019193375A1
(en)
|
2018-04-04 |
2019-10-10 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Use of fzd7 inhibitors for the treatment of retinal neovascularization
|
CN112272516B
(zh)
|
2018-04-06 |
2023-05-30 |
儿童医疗中心有限公司 |
用于体细胞重新编程和调整印记的组合物和方法
|
EP3774907A1
(en)
|
2018-04-13 |
2021-02-17 |
Sangamo Therapeutics France |
Chimeric antigen receptor specific for interleukin-23 receptor
|
US10376889B1
(en)
|
2018-04-13 |
2019-08-13 |
Inscripta, Inc. |
Automated cell processing instruments comprising reagent cartridges
|
JP7460539B2
(ja)
|
2018-04-17 |
2024-04-02 |
ザ ジェネラル ホスピタル コーポレイション |
核酸を結合、修飾、および切断する物質の基質選択性および部位のためのin vitroでの高感度アッセイ
|
WO2019204668A1
(en)
|
2018-04-18 |
2019-10-24 |
Casebia Therapeutics Limited Liability Partnership |
Compositions and methods for knockdown of apo(a) by gene editing for treatment of cardiovascular disease
|
EP3781705A4
(en)
|
2018-04-19 |
2022-01-26 |
The Regents of the University of California |
Compositions and methods for gene editing
|
US10557216B2
(en)
|
2018-04-24 |
2020-02-11 |
Inscripta, Inc. |
Automated instrumentation for production of T-cell receptor peptide libraries
|
WO2019209926A1
(en)
|
2018-04-24 |
2019-10-31 |
Inscripta, Inc. |
Automated instrumentation for production of peptide libraries
|
US10858761B2
(en)
|
2018-04-24 |
2020-12-08 |
Inscripta, Inc. |
Nucleic acid-guided editing of exogenous polynucleotides in heterologous cells
|
US20210239681A1
(en)
|
2018-04-27 |
2021-08-05 |
Advaxis, Inc. |
Compositions and methods for evaluating potency of listeria-based immunotherapeutics
|
EP3784351A1
(en)
|
2018-04-27 |
2021-03-03 |
Novartis AG |
Car t cell therapies with enhanced efficacy
|
CA3091490A1
(en)
|
2018-04-27 |
2019-10-31 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Rapamycin resistant cells
|
WO2019213910A1
(en)
*
|
2018-05-10 |
2019-11-14 |
Syngenta Participations Ag |
Methods and compositions for targeted editing of polynucleotides
|
BR112020022612A2
(pt)
|
2018-05-10 |
2021-02-09 |
Auxolytic Ltd |
métodos e composições de terapia genética usando células reguláveis auxotróficas
|
IL278630B2
(en)
|
2018-05-11 |
2024-10-01 |
Lupagen Inc |
Systems and methods for closed loop, real-time modifications of patient cells
|
AU2019265019A1
(en)
|
2018-05-11 |
2020-11-26 |
Beam Therapeutics Inc. |
Methods of substituting pathogenic amino acids using programmable base editor systems
|
WO2019222545A1
(en)
|
2018-05-16 |
2019-11-21 |
Synthego Corporation |
Methods and systems for guide rna design and use
|
WO2019226603A1
(en)
*
|
2018-05-22 |
2019-11-28 |
The Regents Of The University Of California |
Trna/pre-mirna compositions and use in treating cancer
|
EP3797160A1
(en)
|
2018-05-23 |
2021-03-31 |
The Broad Institute Inc. |
Base editors and uses thereof
|
CA3100386A1
(en)
|
2018-05-23 |
2019-11-28 |
National University Of Singapore |
Blockade of cd2 surface expression and expression of chimeric antigen receptors for immunotherapy of t-cell malignancies
|
EP3572512A1
(en)
|
2018-05-24 |
2019-11-27 |
B.R.A.I.N. Ag |
A method for engineering a protein
|
US11866719B1
(en)
|
2018-06-04 |
2024-01-09 |
Inari Agriculture Technology, Inc. |
Heterologous integration of regulatory elements to alter gene expression in wheat cells and wheat plants
|
CN113015797A
(zh)
|
2018-06-05 |
2021-06-22 |
生命编辑制药股份有限公司 |
Rna-指导的核酸酶及其活性片段和变体及其使用方法
|
WO2019236893A2
(en)
*
|
2018-06-07 |
2019-12-12 |
Allen Institute |
Stem cell lines containing endogenous, differentially-expressed tagged proteins, methods of production, and use thereof
|
FR3082208A1
(fr)
|
2018-06-11 |
2019-12-13 |
Fondation Mediterranee Infection |
Methode de modification d'une sequence cible d'acide nucleique d'une cellule hote
|
CN112203725A
(zh)
|
2018-06-13 |
2021-01-08 |
诺华股份有限公司 |
Bcma嵌合抗原受体及其用途
|
US11203744B2
(en)
|
2018-06-21 |
2021-12-21 |
Duke University |
Compositions and methods for the production of pyruvic acid and related products using dynamic metabolic control
|
WO2020002592A1
(en)
|
2018-06-29 |
2020-01-02 |
Stichting Het Nederlands Kanker Instituut - Antoni Van Leeuwenhoek Ziekenhuis |
Traf2 inhibitors for use in the treatment of a cancer
|
EP4070802A1
(en)
|
2018-06-30 |
2022-10-12 |
Inscripta, Inc. |
Instruments, modules, and methods for improved detection of edited sequences in live cells
|
CN112823011A
(zh)
|
2018-07-09 |
2021-05-18 |
加利福尼亚大学董事会 |
基于t细胞的免疫疗法的基因靶标
|
JP2021530212A
(ja)
|
2018-07-13 |
2021-11-11 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California |
レトロトランスポゾンベースの送達媒体及びその使用方法
|
US12018297B2
(en)
|
2018-07-16 |
2024-06-25 |
The Regents Of The University Of Michigan |
Nuclease-mediated nucleic acid modification
|
WO2020018964A1
(en)
|
2018-07-20 |
2020-01-23 |
Fred Hutchinson Cancer Research Center |
Compositions and methods for controlled expression of antigen-specific receptors
|
US20210292761A1
(en)
*
|
2018-07-24 |
2021-09-23 |
Flagship Pioneering Innovations Vi, Llc |
Compositions comprising circular polyribonucleotides and uses thereof
|
WO2020028327A1
(en)
*
|
2018-07-31 |
2020-02-06 |
Intellia Therapeutics, Inc. |
Compositions and methods for hydroxyacid oxidase 1 ( hao1) gene editing for treating primary hyperoxaluria type 1 (ph1)
|
US11939593B2
(en)
|
2018-08-01 |
2024-03-26 |
University Of Georgia Research Foundation, Inc. |
Compositions and methods for improving embryo development
|
EP4442836A3
(en)
|
2018-08-01 |
2024-12-18 |
Mammoth Biosciences, Inc. |
Programmable nuclease compositions and methods of use thereof
|
EP3829652A4
(en)
*
|
2018-08-01 |
2022-05-11 |
University of Maryland, Baltimore |
MODULATION OF MTORC1 ACTIVITY AND AUTOPHAGY BY CIB2-RHEB INTERACTION
|
KR20210040985A
(ko)
|
2018-08-07 |
2021-04-14 |
가부시키가이샤 모달리스 |
신규 전사 액티베이터
|
KR20210046006A
(ko)
|
2018-08-10 |
2021-04-27 |
상가모 테라퓨틱스 프랑스 |
Tnfr2 도메인을 포함하는 신규한 car 작제물
|
US11142740B2
(en)
|
2018-08-14 |
2021-10-12 |
Inscripta, Inc. |
Detection of nuclease edited sequences in automated modules and instruments
|
US10752874B2
(en)
|
2018-08-14 |
2020-08-25 |
Inscripta, Inc. |
Instruments, modules, and methods for improved detection of edited sequences in live cells
|
US10532324B1
(en)
|
2018-08-14 |
2020-01-14 |
Inscripta, Inc. |
Instruments, modules, and methods for improved detection of edited sequences in live cells
|
KR20210044795A
(ko)
*
|
2018-08-15 |
2021-04-23 |
지머젠 인코포레이티드 |
고 처리량 대사 공학에서 CRISPRi의 응용
|
US12150967B2
(en)
|
2018-08-18 |
2024-11-26 |
Seed Health, Inc. |
Methods and compositions for honey bee health
|
WO2020041380A1
(en)
*
|
2018-08-20 |
2020-02-27 |
The Broad Institute, Inc. |
Methods and compositions for optochemical control of crispr-cas9
|
BR112021003031A8
(pt)
|
2018-08-22 |
2023-05-02 |
Hutchinson Fred Cancer Res |
Imunoterapia direcionada a antígenos kras ou her2
|
JP7541508B2
(ja)
|
2018-08-23 |
2024-08-28 |
サンガモ セラピューティクス, インコーポレイテッド |
操作された標的特異的な塩基エディター
|
CN113423725A
(zh)
|
2018-08-28 |
2021-09-21 |
Vor生物制药股份有限公司 |
遗传工程化造血干细胞及其用途
|
JP2021534785A
(ja)
|
2018-08-28 |
2021-12-16 |
フレッド ハッチンソン キャンサー リサーチ センター |
誘導ノッチシグナル伝達を用いた養子t細胞療法の方法及び組成物
|
WO2020081149A2
(en)
|
2018-08-30 |
2020-04-23 |
Inscripta, Inc. |
Improved detection of nuclease edited sequences in automated modules and instruments
|
US11459551B1
(en)
|
2018-08-31 |
2022-10-04 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
CN112912502A
(zh)
|
2018-08-31 |
2021-06-04 |
耶鲁大学 |
用于增强基于三链体和核酸酶的基因编辑的组合物和方法
|
WO2020048942A1
(en)
|
2018-09-04 |
2020-03-12 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for enhancing cytotoxic t lymphocyte-dependent immune responses
|
US20210278420A1
(en)
|
2018-09-05 |
2021-09-09 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and compositions for treating asthma and allergic diseases
|
US10724052B2
(en)
|
2018-09-07 |
2020-07-28 |
Crispr Therapeutics Ag |
Universal donor cells
|
CN112654702A
(zh)
|
2018-09-07 |
2021-04-13 |
阿斯利康(瑞典)有限公司 |
改进的核酸酶的组合物和方法
|
WO2020053125A1
(en)
|
2018-09-10 |
2020-03-19 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for the treatment of neurofibromatosis
|
CA3112612C
(en)
|
2018-09-13 |
2024-02-27 |
Regeneron Pharmaceuticals, Inc. |
Complement factor h gene knockout rat as a model of c3 glomerulopathy
|
RU2706298C1
(ru)
*
|
2018-09-14 |
2019-11-15 |
Закрытое Акционерное Общество "Биокад" |
НУКЛЕАЗА PaCas9
|
WO2020061591A1
(en)
|
2018-09-21 |
2020-03-26 |
President And Fellows Of Harvard College |
Methods and compositions for treating diabetes, and methods for enriching mrna coding for secreted proteins
|
US20240165232A1
(en)
|
2018-09-24 |
2024-05-23 |
Fred Hutchinson Cancer Research Center |
Chimeric receptor proteins and uses thereof
|
EP3856772A1
(en)
|
2018-09-25 |
2021-08-04 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
Use of antagonists of th17 cytokines for the treatment of bronchial remodeling in patients suffering from allergic asthma
|
GB201815820D0
(en)
|
2018-09-28 |
2018-11-14 |
Univ Wageningen |
Off-target activity inhibitors for guided endonucleases
|
WO2020070062A1
(en)
|
2018-10-01 |
2020-04-09 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Use of tim-3 inhibitors for the treatment of exacerbations in patients suffering from severe asthma
|
WO2020072248A1
(en)
|
2018-10-01 |
2020-04-09 |
North Carolina State University |
Recombinant type i crispr-cas system
|
WO2020072253A1
(en)
|
2018-10-01 |
2020-04-09 |
North Carolina State University |
Recombinant type i crispr-cas system and uses thereof for screening for variant cells
|
CN112867794A
(zh)
|
2018-10-04 |
2021-05-28 |
株式会社钟化 |
用于植物的基因组编辑的dna构建物
|
JP2022512648A
(ja)
|
2018-10-09 |
2022-02-07 |
アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル |
心筋線維化の処置のためのαV-インテグリン(CD51)阻害剤の使用
|
WO2020076976A1
(en)
|
2018-10-10 |
2020-04-16 |
Readcoor, Inc. |
Three-dimensional spatial molecular indexing
|
US11851663B2
(en)
|
2018-10-14 |
2023-12-26 |
Snipr Biome Aps |
Single-vector type I vectors
|
JP2022505139A
(ja)
|
2018-10-15 |
2022-01-14 |
フォンダッツィオーネ・テレソン |
ゲノム編集の方法及び構築物
|
EP3866583A1
(en)
|
2018-10-16 |
2021-08-25 |
Pioneer Hi-Bred International, Inc. |
Genome edited fine mapping and causal gene identification
|
US20210348159A1
(en)
|
2018-10-17 |
2021-11-11 |
Crispr Therapeutics Ag |
Compositions and methods for delivering transgenes
|
AU2019361204A1
(en)
|
2018-10-18 |
2021-05-27 |
Intellia Therapeutics, Inc. |
Compositions and methods for treating alpha-1 antitrypsin deficiencey
|
WO2020079162A1
(en)
|
2018-10-18 |
2020-04-23 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for inducing full ablation of hematopoiesis
|
JP7472121B2
(ja)
|
2018-10-18 |
2024-04-22 |
インテリア セラピューティクス,インコーポレーテッド |
アルブミン遺伝子座からの導入遺伝子発現のための組成物及び方法
|
AU2019360270A1
(en)
|
2018-10-18 |
2021-05-27 |
Intellia Therapeutics, Inc. |
Compositions and methods for expressing factor IX.
|
WO2020082041A1
(en)
|
2018-10-18 |
2020-04-23 |
Intellia Therapeutics, Inc. |
Nucleic acid constructs and methods of use
|
US10604746B1
(en)
|
2018-10-22 |
2020-03-31 |
Inscripta, Inc. |
Engineered enzymes
|
US11214781B2
(en)
|
2018-10-22 |
2022-01-04 |
Inscripta, Inc. |
Engineered enzyme
|
US11946047B2
(en)
*
|
2018-10-23 |
2024-04-02 |
Texas Tech University System |
Treatment strategies against anthrax by interfering with critical host factors
|
UY38427A
(es)
|
2018-10-26 |
2020-05-29 |
Novartis Ag |
Métodos y composiciones para terapia con células oculares
|
US11407995B1
(en)
|
2018-10-26 |
2022-08-09 |
Inari Agriculture Technology, Inc. |
RNA-guided nucleases and DNA binding proteins
|
US20210388389A1
(en)
|
2018-10-30 |
2021-12-16 |
Yale University |
Compositions and methods for rapid and modular generation of chimeric antigen receptor t cells
|
JP2022513408A
(ja)
|
2018-10-31 |
2022-02-07 |
ザイマージェン インコーポレイテッド |
Dnaライブラリーの多重化決定論的アセンブリー
|
US20220010321A1
(en)
|
2018-11-01 |
2022-01-13 |
Keygene N.V. |
Dual guide rna for crispr/cas genome editing in plants cells
|
US11434477B1
(en)
|
2018-11-02 |
2022-09-06 |
Inari Agriculture Technology, Inc. |
RNA-guided nucleases and DNA binding proteins
|
KR20210102231A
(ko)
|
2018-11-09 |
2021-08-19 |
프레드 헛친슨 켄서 리서치 센터 |
메소텔린에 특이적인 t 세포 수용체 및 면역요법에서의 그의 용도
|
WO2020102286A1
(en)
|
2018-11-14 |
2020-05-22 |
University Of Florida Research Foundation, Inc. |
Materials and methods for modifying wolbachia and paratransformation of arthropods
|
MX2021005720A
(es)
|
2018-11-16 |
2021-07-21 |
Astellas Pharma Inc |
Metodo para tratar la distrofia muscular mediante el direccionamiento del gen de utrofina.
|
EP3887538A1
(en)
|
2018-11-28 |
2021-10-06 |
Keygene N.V. |
Targeted enrichment by endonuclease protection
|
EP3887516A1
(en)
*
|
2018-11-29 |
2021-10-06 |
Flagship Pioneering Innovations V, Inc. |
Methods of modulating rna
|
WO2020112195A1
(en)
|
2018-11-30 |
2020-06-04 |
Yale University |
Compositions, technologies and methods of using plerixafor to enhance gene editing
|
KR20200071198A
(ko)
|
2018-12-10 |
2020-06-19 |
네오이뮨텍, 인코퍼레이티드 |
Nrf2 발현 조절 기반 T 세포 항암면역치료법
|
JP7553100B2
(ja)
*
|
2018-12-12 |
2024-09-18 |
国立大学法人九州大学 |
ゲノム編集された細胞の製造方法
|
US11166996B2
(en)
|
2018-12-12 |
2021-11-09 |
Flagship Pioneering Innovations V, Inc. |
Anellovirus compositions and methods of use
|
IL283853B2
(en)
|
2018-12-14 |
2024-10-01 |
Pioneer Hi Bred Int |
Novel crispr-cas systems for genome editing
|
WO2020131862A1
(en)
*
|
2018-12-17 |
2020-06-25 |
The Broad Institute, Inc. |
Crispr-associated transposase systems and methods of use thereof
|
CA3124039A1
(en)
|
2018-12-19 |
2020-06-25 |
King's College London |
Immunotherapeutic methods and compositions
|
MX2021007400A
(es)
|
2018-12-20 |
2021-07-15 |
Regeneron Pharma |
Expansion de repeticiones mediada por nucleasas.
|
AU2019406214A1
(en)
|
2018-12-21 |
2021-08-05 |
Northwestern University |
Use of annexins in preventing and treating muscle membrane injury
|
AU2019417720A1
(en)
*
|
2018-12-24 |
2021-07-08 |
Visterra, Inc. |
Methods for identifying epitopes and paratopes
|
AU2019416108A1
(en)
|
2018-12-27 |
2021-08-12 |
LifeEDIT Therapeutics, Inc. |
Polypeptides useful for gene editing and methods of use
|
WO2020136216A1
(en)
|
2018-12-27 |
2020-07-02 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods of identifying subjects having or at risk of having a coagulation related disorder
|
CN113518829A
(zh)
*
|
2018-12-31 |
2021-10-19 |
Htg分子诊断有限公司 |
检测同一样品中dna和rna的方法
|
KR20220008253A
(ko)
|
2019-01-03 |
2022-01-20 |
엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔 (인쎄름) |
암을 앓는 대상에서 cd8+ t 세포 의존성 면역 반응을 향상시키기 위한 방법 및 약학적 조성물
|
WO2020142754A2
(en)
|
2019-01-04 |
2020-07-09 |
Mammoth Biosciences, Inc. |
Programmable nuclease improvements and compositions and methods for nucleic acid amplification and detection
|
TWI852977B
(zh)
*
|
2019-01-10 |
2024-08-21 |
美商健生生物科技公司 |
前列腺新抗原及其用途
|
US20220106584A1
(en)
|
2019-01-14 |
2022-04-07 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and kits for generating and selecting a variant of a binding protein with increased binding affinity and/or specificity
|
WO2020150144A1
(en)
|
2019-01-15 |
2020-07-23 |
Seminis Vegetable Seeds, Inc. |
Green bean plants with improved disease resistance
|
JP2022522265A
(ja)
|
2019-01-16 |
2022-04-15 |
アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル |
エリスロフェロンの変異体及びその使用
|
US20220072084A1
(en)
|
2019-01-17 |
2022-03-10 |
Universitat Autonoma De Barcelona (Uab) |
Therapeutic nanoconjugates and uses thereof
|
US11419932B2
(en)
|
2019-01-24 |
2022-08-23 |
Massachusetts Institute Of Technology |
Nucleic acid nanostructure platform for antigen presentation and vaccine formulations formed therefrom
|
EP3918059A4
(en)
*
|
2019-01-29 |
2022-11-30 |
Flagship Pioneering Innovations V, Inc. |
COMPOSITIONS CONTAINING AN ENDONUCLEASIS AND METHODS OF PURIFICATION OF AN ENDONUCLEASE
|
WO2020163396A1
(en)
|
2019-02-04 |
2020-08-13 |
The General Hospital Corporation |
Adenine dna base editor variants with reduced off-target rna editing
|
US20220117911A1
(en)
|
2019-02-04 |
2022-04-21 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and compositions for modulating blood-brain barrier
|
WO2020163856A1
(en)
|
2019-02-10 |
2020-08-13 |
The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone |
Modified mitochondrion and methods of use thereof
|
CA3129532A1
(en)
|
2019-02-15 |
2020-08-20 |
Crispr Therapeutics Ag |
Gene editing for hemophilia a with improved factor viii expression
|
KR20210139271A
(ko)
|
2019-02-15 |
2021-11-22 |
시그마-알드리치 컴퍼니., 엘엘씨 |
Crispr/cas 융합 단백질 및 시스템
|
WO2020169472A2
(en)
|
2019-02-18 |
2020-08-27 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods of inducing phenotypic changes in macrophages
|
GB201902277D0
(en)
|
2019-02-19 |
2019-04-03 |
King S College London |
Therapeutic agents
|
WO2020172332A1
(en)
|
2019-02-20 |
2020-08-27 |
Fred Hutchinson Cancer Research Center |
Binding proteins specific for ras neoantigens and uses thereof
|
WO2020176389A1
(en)
|
2019-02-25 |
2020-09-03 |
Caribou Biosciences, Inc. |
Plasmids for gene editing
|
WO2020180699A1
(en)
*
|
2019-03-01 |
2020-09-10 |
Arbor Biotechnologies, Inc. |
Novel crispr dna targeting enzymes and systems
|
US20220127661A1
(en)
|
2019-03-04 |
2022-04-28 |
King Abdullah University Of Science And Technology |
Compositions and methods of targeted nucleic acid enrichment by loop adapter protection and exonuclease digestion
|
CN116732004A
(zh)
|
2019-03-07 |
2023-09-12 |
加利福尼亚大学董事会 |
CRISPR-Cas效应子多肽和其使用方法
|
US11053515B2
(en)
|
2019-03-08 |
2021-07-06 |
Zymergen Inc. |
Pooled genome editing in microbes
|
CA3129871A1
(en)
|
2019-03-08 |
2020-09-17 |
Zymergen Inc. |
Iterative genome editing in microbes
|
MX2021010837A
(es)
|
2019-03-11 |
2021-10-14 |
Fred Hutchinson Cancer Center |
Receptores en linfocitos t de la proteina 1 de tumor de wilms (wt1) de alta avidez.
|
MX2021010938A
(es)
|
2019-03-11 |
2022-01-06 |
Sorrento Therapeutics Inc |
Proceso mejorado para integración de constructos de adn utilizando endonucleasas guiadas por arn.
|
AU2020239225A1
(en)
*
|
2019-03-12 |
2021-09-30 |
Bayer Healthcare Llc |
Novel high fidelity RNA-programmable endonuclease systems and uses thereof
|
CA3127813A1
(en)
|
2019-03-18 |
2020-09-24 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas screening platform to identify genetic modifiers of tau seeding or aggregation
|
WO2020190927A1
(en)
|
2019-03-18 |
2020-09-24 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas dropout screening platform to reveal genetic vulnerabilities associated with tau aggregation
|
WO2020191234A1
(en)
|
2019-03-19 |
2020-09-24 |
The Broad Institute, Inc. |
Methods and compositions for editing nucleotide sequences
|
US11001831B2
(en)
|
2019-03-25 |
2021-05-11 |
Inscripta, Inc. |
Simultaneous multiplex genome editing in yeast
|
WO2020198174A1
(en)
|
2019-03-25 |
2020-10-01 |
Inscripta, Inc. |
Simultaneous multiplex genome editing in yeast
|
WO2020198408A1
(en)
|
2019-03-27 |
2020-10-01 |
Pioneer Hi-Bred International, Inc. |
Plant explant transformation
|
WO2020193740A1
(en)
|
2019-03-28 |
2020-10-01 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
New strategy for treating pancreatic cancer
|
WO2020201073A1
(en)
|
2019-03-29 |
2020-10-08 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for the treatment of keloid, hypertrophic scars and/or hyperpigmentation disorders
|
WO2020201362A2
(en)
|
2019-04-02 |
2020-10-08 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods of predicting and preventing cancer in patients having premalignant lesions
|
CN113727603B
(zh)
|
2019-04-03 |
2024-03-19 |
瑞泽恩制药公司 |
用于将抗体编码序列插入到安全港基因座中的方法和组合物
|
SG11202108524SA
(en)
|
2019-04-04 |
2021-09-29 |
Regeneron Pharma |
Methods for scarless introduction of targeted modifications into targeting vectors
|
SG11202108454RA
(en)
|
2019-04-04 |
2021-09-29 |
Regeneron Pharma |
Non-human animals comprising a humanized coagulation factor 12 locus
|
WO2020206202A1
(en)
|
2019-04-05 |
2020-10-08 |
Danisco Us Inc |
Methods for integrating a donor dna sequence into the genome of bacillus using linear recombinant dna constructs and compositions thereof
|
EP3950942A4
(en)
|
2019-04-05 |
2023-01-18 |
Osaka University |
KNOCK-IN CELL PRODUCTION PROCESS
|
MX2021012157A
(es)
|
2019-04-05 |
2022-01-06 |
Danisco Us Inc |
Métodos para la integración de polinucleótidos en el genoma de bacillus usando constructos de adn recombinante circular dual y composiciones de los mismos.
|
WO2020208082A1
(en)
|
2019-04-09 |
2020-10-15 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Method for treating cmv related diseases
|
WO2020208185A1
(en)
|
2019-04-12 |
2020-10-15 |
Astrazeneca Ab |
Compositions and methods for improved gene editing
|
GB201905360D0
(en)
|
2019-04-16 |
2019-05-29 |
Univ Nottingham |
Fungal strains, production and uses thereof
|
EP3959320A1
(en)
|
2019-04-24 |
2022-03-02 |
Novartis AG |
Compositions and methods for selective protein degradation
|
EA202192931A1
(ru)
|
2019-04-30 |
2022-02-22 |
Эдиджен Инк. |
Способ прогнозирования эффективности лечения гемоглобинопатии
|
EP3963109A1
(en)
|
2019-04-30 |
2022-03-09 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and compositions for treating melanoma
|
BR112021021912A2
(pt)
*
|
2019-04-30 |
2022-01-18 |
Emendobio Inc |
Nova nuclease omni-50 crispr
|
US11692197B2
(en)
|
2019-05-06 |
2023-07-04 |
Inari Agriculture Technology, Inc. |
Delivery of biological molecules to plant cells
|
US20210047649A1
(en)
|
2019-05-08 |
2021-02-18 |
Vertex Pharmaceuticals Incorporated |
Crispr/cas all-in-two vector systems for treatment of dmd
|
EP3966334A1
(en)
|
2019-05-10 |
2022-03-16 |
Basf Se |
Regulatory nucleic acid molecules for enhancing gene expression in plants
|
JP2022534813A
(ja)
|
2019-05-23 |
2022-08-03 |
ブイオーアール バイオファーマ インコーポレーテッド |
Cd33改変のための組成物および方法
|
WO2020239623A1
(en)
|
2019-05-24 |
2020-12-03 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Use of ngal inhibitors for the treating chronic wound
|
US20220307021A1
(en)
|
2019-06-04 |
2022-09-29 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
A neuropilin antagonist in combination with a p38alpha-kinase inhibitor for the treatment of cancer
|
CN113874510A
(zh)
|
2019-06-04 |
2021-12-31 |
瑞泽恩制药公司 |
包括具有β滑移突变的人源化TTR基因座的非人动物和使用方法
|
US20220229072A1
(en)
|
2019-06-04 |
2022-07-21 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Use of cd9 as a biomarker and as a biotarget in glomerulonephritis or glomerulosclerosis
|
CA3139122C
(en)
|
2019-06-06 |
2023-04-25 |
Inscripta, Inc. |
Curing for recursive nucleic acid-guided cell editing
|
CA3137764A1
(en)
|
2019-06-07 |
2020-12-10 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized albumin locus
|
BR112021024288A2
(pt)
|
2019-06-07 |
2022-02-15 |
Scribe Therapeutics Inc |
Sistemas casx modificados
|
CA3137765A1
(en)
|
2019-06-14 |
2020-12-17 |
Regeneron Pharmaceuticals, Inc. |
Models of tauopathy
|
WO2020249769A1
(en)
|
2019-06-14 |
2020-12-17 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and compositions for treating ocular diseases related to mitochondrial dna maintenance
|
US10907125B2
(en)
|
2019-06-20 |
2021-02-02 |
Inscripta, Inc. |
Flow through electroporation modules and instrumentation
|
WO2020257395A1
(en)
|
2019-06-21 |
2020-12-24 |
Inscripta, Inc. |
Genome-wide rationally-designed mutations leading to enhanced lysine production in e. coli
|
CN114630910A
(zh)
|
2019-06-25 |
2022-06-14 |
伊纳瑞农业技术有限公司 |
改善的同源依赖修复基因组编辑
|
US10927385B2
(en)
|
2019-06-25 |
2021-02-23 |
Inscripta, Inc. |
Increased nucleic-acid guided cell editing in yeast
|
US11905532B2
(en)
|
2019-06-25 |
2024-02-20 |
Massachusetts Institute Of Technology |
Compositions and methods for molecular memory storage and retrieval
|
EP3990475A1
(en)
|
2019-06-27 |
2022-05-04 |
Regeneron Pharmaceuticals, Inc. |
Modeling tdp-43 proteinopathy
|
US20220354863A1
(en)
|
2019-07-02 |
2022-11-10 |
Inserm (Institut National De La Santè Et De La Recherch Médicale) |
Methods for the prophylactic treatment of cancer in patients suffering from pancreatitis
|
WO2021001431A1
(en)
|
2019-07-02 |
2021-01-07 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Use of pi3ka-selective inhibitors for treating metastatic disease in patients suffering from pancreatic cancer
|
GB201909597D0
(en)
|
2019-07-03 |
2019-08-14 |
Univ Wageningen |
Crispr type v-u1 system from mycobacterium mucogenicum and uses thereof
|
EP3998086A4
(en)
|
2019-07-12 |
2023-08-30 |
Riken |
THERAPEUTIC AGENT FOR A DISEASE CAUSED BY A DOMINANT MUTED GENE
|
US10801042B1
(en)
|
2019-07-15 |
2020-10-13 |
Vigene Biosciences, Inc. |
Use of ion concentrations to increase the packaging efficiency of recombinant adeno-associated virus
|
JP2022541761A
(ja)
|
2019-07-15 |
2022-09-27 |
メドイミューン・リミテッド |
タンパク質二量体化の三分子システム及び使用方法
|
US10653731B1
(en)
|
2019-07-15 |
2020-05-19 |
Vigene Biosciences Inc. |
Recombinantly-modified adeno-associated virus (rAAV) having improved packaging efficiency
|
US10557149B1
(en)
|
2019-07-15 |
2020-02-11 |
Vigene Biosciences, Inc. |
Recombinantly-modified adeno-associated virus helper vectors and their use to improve the packaging efficiency of recombinantly-modified adeno-associated virus
|
WO2021009299A1
(en)
|
2019-07-17 |
2021-01-21 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Bcl-xl:fkbp12 fusion proteins suitable for screening agents capable of slowing down the aging process
|
WO2021013911A1
(en)
|
2019-07-24 |
2021-01-28 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Inhibitors of the sting pathway for the treatment of hidradenitis suppurativa
|
US20220275105A1
(en)
|
2019-08-02 |
2022-09-01 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Neutralizing granzyme b for providing cardioprotection in a subject who experienced a myocardial infarction
|
US12179199B2
(en)
|
2019-08-09 |
2024-12-31 |
The Regents Of The University Of California |
Microfluidic single-cell pairing array for studying cell-cell interactions in isolated compartments
|
WO2021028359A1
(en)
|
2019-08-09 |
2021-02-18 |
Sangamo Therapeutics France |
Controlled expression of chimeric antigen receptors in t cells
|
BR112022002695A2
(pt)
*
|
2019-08-12 |
2022-08-23 |
Lifeedit Therapeutics Inc |
Nucleases guiadas por rna, fragmentos ativos e variantes das mesmas e métodos de uso
|
AU2020334064A1
(en)
|
2019-08-20 |
2022-03-03 |
Fred Hutchinson Cancer Center |
T-cell immunotherapy specific for WT-1
|
AU2020337918A1
(en)
*
|
2019-08-28 |
2022-03-03 |
The Board Of Trustees Of The Leland Stanford Junior University |
Modified circular RNAs and methods of use thereof
|
US20220290160A1
(en)
|
2019-08-28 |
2022-09-15 |
Vor Biopharma Inc. |
Compositions and methods for cll1 modification
|
KR20220047381A
(ko)
|
2019-08-28 |
2022-04-15 |
보르 바이오파마 인크. |
Cd123 변형을 위한 조성물 및 방법
|
CN115151275A
(zh)
|
2019-08-30 |
2022-10-04 |
耶鲁大学 |
用于向细胞递送核酸的组合物和方法
|
WO2021046155A1
(en)
|
2019-09-03 |
2021-03-11 |
Voyager Therapeutics, Inc. |
Vectorized editing of nucleic acids to correct overt mutations
|
JP2022547105A
(ja)
|
2019-09-04 |
2022-11-10 |
博雅▲輯▼因(北京)生物科技有限公司 |
オフターゲット評価に基づく遺伝子編集治療の評価方法
|
WO2021044012A1
(en)
|
2019-09-05 |
2021-03-11 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Method of treatment and pronostic of acute myeloid leukemia
|
MX2022002663A
(es)
|
2019-09-05 |
2022-04-07 |
Crispr Therapeutics Ag |
Celulas donantes universales.
|
BR112022003996A2
(pt)
|
2019-09-05 |
2022-05-31 |
Benson Hill Inc |
Composições e métodos para modificar genomas
|
US11118196B2
(en)
|
2019-09-05 |
2021-09-14 |
Crispr Therapeutics Ag |
Universal donor cells
|
MX2022002919A
(es)
*
|
2019-09-10 |
2022-09-09 |
Science Solutions Llc |
Nuevas endonucleasas guiadas por rna crispr-cas tipo ii y tipo v de clase 2.
|
US20230203515A1
(en)
|
2019-09-12 |
2023-06-29 |
Basf Se |
Regulatory Nucleic Acid Molecules for Enhancing Gene Expression in Plants
|
WO2021047775A1
(en)
|
2019-09-12 |
2021-03-18 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Use of inhibitors of tgfb/activinb signaling pathway for the treatment of patients suffering from medulloblastoma group 3
|
KR20220062079A
(ko)
|
2019-09-13 |
2022-05-13 |
리제너론 파마슈티칼스 인코포레이티드 |
지질 나노입자에 의해 전달되는 CRISPR/Cas 시스템을 사용한 동물에서의 전사 조절
|
CN114391040A
(zh)
|
2019-09-23 |
2022-04-22 |
欧米茄治疗公司 |
用于调节载脂蛋白b(apob)基因表达的组合物和方法
|
EP4041894A1
(en)
|
2019-09-23 |
2022-08-17 |
Omega Therapeutics, Inc. |
COMPOSITIONS AND METHODS FOR MODULATING HEPATOCYTE NUCLEAR FACTOR 4-ALPHA (HNF4a) GENE EXPRESSION
|
US11542513B2
(en)
|
2019-09-26 |
2023-01-03 |
Seminis Vegetable Seeds, Inc. |
Lettuce plants having resistance to Nasonovia ribisnigri biotype Nr:1
|
WO2021063968A1
(en)
|
2019-09-30 |
2021-04-08 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Method and composition for diagnosing chronic obstructive pulmonary disease
|
CN114929873A
(zh)
*
|
2019-09-30 |
2022-08-19 |
西格马-奥尔德里奇有限责任公司 |
使用靶向核酸酶调节微生物群的组成
|
WO2021067788A1
(en)
*
|
2019-10-03 |
2021-04-08 |
Artisan Development Labs, Inc. |
Crispr systems with engineered dual guide nucleic acids
|
US20220354811A1
(en)
|
2019-10-03 |
2022-11-10 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and compositions for modulating macrophages polarization
|
WO2021069387A1
(en)
|
2019-10-07 |
2021-04-15 |
Basf Se |
Regulatory nucleic acid molecules for enhancing gene expression in plants
|
EP4043473A4
(en)
|
2019-10-11 |
2024-03-27 |
Sumitomo Chemical Company, Limited |
METHOD FOR PRODUCING NUCLEIC ACID OLIGOMERS
|
EP4045658A4
(en)
*
|
2019-10-15 |
2024-01-03 |
Agency for Science, Technology and Research |
Assays for measuring nucleic acid modifying enzyme activity
|
EP3808766A1
(en)
|
2019-10-15 |
2021-04-21 |
Sangamo Therapeutics France |
Chimeric antigen receptor specific for interleukin-23 receptor
|
WO2021078359A1
(en)
|
2019-10-21 |
2021-04-29 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Use of inhibitors of cubilin for the treatment of chronic kidney diseases
|
WO2021081264A1
(en)
*
|
2019-10-24 |
2021-04-29 |
Pairwise Plants Services, Inc. |
Optimized crispr-cas nucleases and base editors and methods of use thereof
|
WO2021083959A1
(en)
|
2019-10-29 |
2021-05-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and compositions for treating uveal melanoma
|
MX2022005572A
(es)
|
2019-11-08 |
2022-06-09 |
Regeneron Pharma |
Estrategias crispr y aav para la terapia de retinosquisis juvenil ligada al cromosoma x.
|
IL292351A
(en)
*
|
2019-11-13 |
2022-06-01 |
Crispr Therapeutics Ag |
Methods of manufacturing car-t cells
|
AR120469A1
(es)
*
|
2019-11-13 |
2022-02-16 |
Crispr Therapeutics Ag |
Proceso de fabricación para hacer células t que expresen receptores de antígeno quiméricos
|
WO2021102059A1
(en)
|
2019-11-19 |
2021-05-27 |
Inscripta, Inc. |
Methods for increasing observed editing in bacteria
|
WO2021101950A1
(en)
|
2019-11-19 |
2021-05-27 |
Danisco Us Inc |
Selection marker free methods for modifying the genome of bacillus and compositions thereof
|
US20230037413A1
(en)
|
2019-11-20 |
2023-02-09 |
Corbion Biotech, Inc. |
Sucrose invertase variants
|
CN110938659B
(zh)
*
|
2019-11-22 |
2022-05-10 |
广东省微生物研究所(广东省微生物分析检测中心) |
一种提高纤维堆囊菌埃博霉素产量的dCas9载体及其构建方法
|
WO2021099600A1
(en)
|
2019-11-22 |
2021-05-27 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Inhibitors of adrenomedullin for the treatment of acute myeloid leukemia by eradicating leukemic stem cells
|
WO2021108363A1
(en)
|
2019-11-25 |
2021-06-03 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas-mediated upregulation of humanized ttr allele
|
MX2022006365A
(es)
|
2019-11-26 |
2022-06-22 |
Novartis Ag |
Receptores de antigeno quimerico cd19 y cd22 y usos de los mismos.
|
EP4065701A4
(en)
|
2019-11-27 |
2023-11-29 |
Danmarks Tekniske Universitet |
CONSTRUCTS, COMPOSITIONS AND METHODS THEREOF WITH IMPROVED GENOMEDITING EFFICIENCY AND SPECIFICITY
|
EP4065699A1
(en)
|
2019-11-27 |
2022-10-05 |
Promega Corporation |
Multipartite luciferase peptides and polypeptides
|
JP2023503979A
(ja)
|
2019-11-27 |
2023-02-01 |
アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル |
子宮内膜症の治療におけるニューロピリン拮抗薬の使用。
|
EP4064830A1
(en)
|
2019-11-29 |
2022-10-05 |
Basf Se |
Increasing resistance against fungal infections in plants
|
CN114787365A
(zh)
|
2019-12-03 |
2022-07-22 |
巴斯夫欧洲公司 |
用于在植物中增强基因表达的调节性核酸分子
|
AU2020398213A1
(en)
|
2019-12-03 |
2022-06-16 |
Beam Therapeutics Inc. |
Synthetic guide RNA, compositions, methods, and uses thereof
|
WO2021118626A1
(en)
|
2019-12-10 |
2021-06-17 |
Inscripta, Inc. |
Novel mad nucleases
|
US10704033B1
(en)
|
2019-12-13 |
2020-07-07 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
GB201918586D0
(en)
|
2019-12-17 |
2020-01-29 |
Patterson James |
Engineered platelets for targeted delivery of a therapeutic agent
|
CA3157127A1
(en)
|
2019-12-18 |
2021-06-24 |
Aamir MIR |
Cascade/dcas3 complementation assays for in vivo detection of nucleic acid-guided nuclease edited cells
|
KR20220116504A
(ko)
|
2019-12-19 |
2022-08-23 |
바스프 에스이 |
정밀 화학물의 제조에서 공시 수율, 탄소-전환-효율 및 탄소 기질 적응성의 증가
|
EP4077658A1
(en)
|
2019-12-20 |
2022-10-26 |
Basf Se |
Decreasing toxicity of terpenes and increasing the production potential in micro-organisms
|
IL271656A
(en)
|
2019-12-22 |
2021-06-30 |
Yeda Res & Dev |
System and methods for identifying cells that have undergone genome editing
|
EP3842452A1
(en)
|
2019-12-26 |
2021-06-30 |
Universitat Autònoma de Barcelona |
Scaffold proteins and therapeutic nanoconjugates based on nidogen
|
JP2023516538A
(ja)
|
2019-12-30 |
2023-04-20 |
博雅▲緝▼因(北京)生物科技有限公司 |
Ucart細胞を精製する方法及び応用
|
EP4086340A1
(en)
|
2019-12-30 |
2022-11-09 |
Edigene Biotechnology Inc. |
Universal car-t targeting t-cell lymphoma cell and preparation method therefor and use thereof
|
WO2021138560A2
(en)
|
2020-01-02 |
2021-07-08 |
The Trustees Of Columbia University In The City Of New York |
Programmable and portable crispr-cas transcriptional activation in bacteria
|
CN110982820A
(zh)
*
|
2020-01-03 |
2020-04-10 |
云南中烟工业有限责任公司 |
一种烟草单倍体的基因编辑方法
|
US10689669B1
(en)
|
2020-01-11 |
2020-06-23 |
Inscripta, Inc. |
Automated multi-module cell processing methods, instruments, and systems
|
EP4090770A1
(en)
|
2020-01-17 |
2022-11-23 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and compositions for treating melanoma
|
CA3168604A1
(en)
|
2020-01-21 |
2021-07-29 |
Limagrain Europe |
Wheat haploid inducer plant and uses
|
WO2021151073A2
(en)
*
|
2020-01-24 |
2021-07-29 |
The General Hospital Corporation |
Unconstrained genome targeting with near-pamless engineered crispr-cas9 variants
|
WO2021151085A2
(en)
*
|
2020-01-24 |
2021-07-29 |
The General Hospital Corporation |
Crispr-cas enzymes with enhanced on-target activity
|
CA3157061A1
(en)
|
2020-01-27 |
2021-08-05 |
Christian SILTANEN |
Electroporation modules and instrumentation
|
EP4096396A1
(en)
|
2020-01-28 |
2022-12-07 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized pnpla3 locus and methods of use
|
US20230095584A1
(en)
|
2020-01-29 |
2023-03-30 |
Sumitomo Chemical Company, Limited |
Process of preparing nucleic acid oligomer
|
EP4098655A4
(en)
|
2020-01-29 |
2024-02-28 |
Sumitomo Chemical Company, Limited |
PROCESS FOR THE PRODUCTION OF NUCLEIC ACID OLIGOMERS
|
EP4099821A1
(en)
|
2020-02-07 |
2022-12-14 |
Regeneron Pharmaceuticals, Inc. |
<smallcaps/>? ? ?klkb1? ? ? ? ?non-human animals comprising a humanizedlocus and methods of use
|
EP4107273A1
(en)
|
2020-02-21 |
2022-12-28 |
Limagrain Europe |
Prime editing technology for plant genome engineering
|
EP4110817A1
(en)
|
2020-02-26 |
2023-01-04 |
Sorrento Therapeutics, Inc. |
Activatable antigen binding proteins with universal masking moieties
|
CA3167369A1
(en)
|
2020-03-04 |
2021-09-10 |
Tara YOUNG |
Methods and compositions for sensitization of tumor cells to immune therapy
|
WO2021183720A1
(en)
|
2020-03-11 |
2021-09-16 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating forkhead box p3 (foxp3) gene expression
|
KR20210116324A
(ko)
|
2020-03-12 |
2021-09-27 |
기초과학연구원 |
게놈 서열 변이를 가지는 세포 사멸 유도용 조성물 및 상기 조성물을 이용한 세포 사멸 유도 방법
|
WO2021188840A1
(en)
|
2020-03-19 |
2021-09-23 |
Rewrite Therapeutics, Inc. |
Methods and compositions for directed genome editing
|
MX2022011683A
(es)
|
2020-03-20 |
2022-12-08 |
Inst Nat Sante Rech Med |
Receptor de antigeno quimerico especifico para cd45rc humano y usos del mismo.
|
US20230102342A1
(en)
|
2020-03-23 |
2023-03-30 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized ttr locus comprising a v30m mutation and methods of use
|
JPWO2021193865A1
(sr)
|
2020-03-26 |
2021-09-30 |
|
|
CN115335387A
(zh)
|
2020-03-27 |
2022-11-11 |
住友化学株式会社 |
核酸寡聚物的制造方法
|
US12057197B2
(en)
|
2020-04-03 |
2024-08-06 |
Creyon Bio, Inc. |
Oligonucleotide-based machine learning
|
JP2023522848A
(ja)
|
2020-04-08 |
2023-06-01 |
アストラゼネカ・アクチエボラーグ |
改善された部位特異的改変のための組成物及び方法
|
US20230132275A1
(en)
|
2020-04-08 |
2023-04-27 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Use of cdon inhibitors for the treatment of endothelial dysfunction
|
TW202208626A
(zh)
|
2020-04-24 |
2022-03-01 |
美商生命編輯公司 |
Rna引導核酸酶及其活性片段與變體,以及使用方法
|
US20210332388A1
(en)
|
2020-04-24 |
2021-10-28 |
Inscripta, Inc. |
Compositions, methods, modules and instruments for automated nucleic acid-guided nuclease editing in mammalian cells
|
US20230167191A1
(en)
|
2020-04-24 |
2023-06-01 |
Sorrento Therapeutics, Inc. |
Memory Dimeric Antigen Receptors (mDARs)
|
US20230348852A1
(en)
|
2020-04-27 |
2023-11-02 |
Novartis Ag |
Methods and compositions for ocular cell therapy
|
IL297851A
(en)
|
2020-05-04 |
2023-01-01 |
Saliogen Therapeutics Inc |
Transposition-based treatments
|
BR112022020072A2
(pt)
|
2020-05-05 |
2022-11-29 |
Genus Plc |
Genes cd163, células, linhagens de células, par de grnas, complexo crispr, métodos para editar um gene cd163, preparar uma célula, produzir animais e determinar a presença ou ausência de uma sequência editada, embrião, leitão ou porco adulto, iniciador de pcr, sonda de pcr, usos e método de criação de um porco resistente ao prrsv
|
WO2021224633A1
(en)
|
2020-05-06 |
2021-11-11 |
Orchard Therapeutics (Europe) Limited |
Treatment for neurodegenerative diseases
|
WO2021224401A1
(en)
|
2020-05-07 |
2021-11-11 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and compositions for determining a reference range of β-galactose exposure platelet
|
DE112021002672T5
(de)
|
2020-05-08 |
2023-04-13 |
President And Fellows Of Harvard College |
Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz
|
EP4150081A1
(en)
|
2020-05-13 |
2023-03-22 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Base editing approaches for the treatment of betahemoglobinopathies
|
WO2021230385A1
(en)
|
2020-05-15 |
2021-11-18 |
Astellas Pharma Inc. |
Method for treating muscular dystrophy by targeting utrophin gene
|
US11787841B2
(en)
|
2020-05-19 |
2023-10-17 |
Inscripta, Inc. |
Rationally-designed mutations to the thrA gene for enhanced lysine production in E. coli
|
US11263022B2
(en)
*
|
2020-05-21 |
2022-03-01 |
Microsoft Technology Licensing, Llc |
Mechanism to turn on/off post-processing features in the device media foundation transform
|
EP4161552A1
(en)
|
2020-06-05 |
2023-04-12 |
The Broad Institute, Inc. |
Compositions and methods for treating neoplasia
|
US20230235326A1
(en)
|
2020-06-05 |
2023-07-27 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for treating ocular diseases
|
IL298473A
(en)
|
2020-06-11 |
2023-01-01 |
Novartis Ag |
Zbtb32 inhibitors and uses thereof
|
CN111748539B
(zh)
*
|
2020-06-11 |
2021-10-22 |
中国农业科学院农产品加工研究所 |
CRISPR/LpCas9基因编辑系统及其应用
|
EP4168006A1
(en)
|
2020-06-18 |
2023-04-26 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
New strategy for treating pancreatic cancer
|
CN116096920A
(zh)
|
2020-06-23 |
2023-05-09 |
科罗拉多大学董事会法人团体 |
用于诊断呼吸道病原体和预测covid-19相关结果的方法
|
US20230232796A1
(en)
|
2020-06-26 |
2023-07-27 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized ace2 locus
|
WO2022008597A1
(en)
|
2020-07-08 |
2022-01-13 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical composition for the treatment of infectious diseases
|
JP2023533979A
(ja)
*
|
2020-07-08 |
2023-08-07 |
ザ ジャクソン ラボラトリー |
ヒト自然免疫機能を支えるトランスジェニックマウスモデル
|
BR112022026885A2
(pt)
|
2020-07-09 |
2023-01-24 |
Modalis Therapeutics Corp |
Método para tratar doença de alzheimer por direcionamento de gene mapt
|
EP4179079A1
(en)
|
2020-07-10 |
2023-05-17 |
Horizon Discovery Limited |
Method for producing genetically modified cells
|
AU2021204717A1
(en)
|
2020-07-15 |
2022-02-03 |
Seminis Vegetable Seeds, Inc. |
Green Bean Plants with Improved Disease Resistance
|
AU2021310363A1
(en)
|
2020-07-15 |
2023-03-16 |
LifeEDIT Therapeutics, Inc. |
Uracil stabilizing proteins and active fragments and variants thereof and methods of use
|
US20230323299A1
(en)
|
2020-08-03 |
2023-10-12 |
Inserm (Institut National De La Santé Et De La Recherch Médicale) |
Population of treg cells functionally committed to exert a regulatory activity and their use for adoptive therapy
|
WO2022032085A1
(en)
|
2020-08-07 |
2022-02-10 |
The Jackson Laboratory |
Targeted sequence insertion compositions and methods
|
WO2022036180A1
(en)
|
2020-08-13 |
2022-02-17 |
Yale University |
Compositions and methods for engineering and selection of car t cells with desired phenotypes
|
US20220049303A1
(en)
|
2020-08-17 |
2022-02-17 |
Readcoor, Llc |
Methods and systems for spatial mapping of genetic variants
|
BR112023002885A2
(pt)
|
2020-08-18 |
2023-03-21 |
Pioneer Hi Bred Int |
Genes de resistência a múltiplas doenças e seus empilhamentos genômicos
|
MX2023002041A
(es)
|
2020-08-20 |
2023-04-27 |
A2 Biotherapeutics Inc |
Composiciones y métodos para tratar cánceres positivos para mesotelina.
|
FI4058474T3
(fi)
|
2020-08-20 |
2024-07-01 |
A2 Biotherapeutics Inc |
Koostumuksia ja menetelmiä EGFR-positiivisten syöpien hoitoon
|
CA3188867A1
(en)
|
2020-08-20 |
2022-02-24 |
Xueyin Wang |
Compositions and methods for treating ceacam positive cancers
|
CN116438302A
(zh)
*
|
2020-08-24 |
2023-07-14 |
宏基因组学公司 |
用于对货物核苷酸序列转位的系统和方法
|
EP4204564A1
(en)
|
2020-08-28 |
2023-07-05 |
Vor Biopharma Inc. |
Compositions and methods for cd123 modification
|
EP4204565A1
(en)
|
2020-08-28 |
2023-07-05 |
Vor Biopharma Inc. |
Compositions and methods for cll1 modification
|
CA3193424A1
(en)
|
2020-08-31 |
2022-03-03 |
Yale University |
Compositions and methods for delivery of nucleic acids to cells
|
CA3194019A1
(en)
|
2020-09-04 |
2022-03-10 |
National University Corporation Kobe University |
Miniaturized cytidine deaminase-containing complex for modifying double-stranded dna
|
KR20230084505A
(ko)
|
2020-09-11 |
2023-06-13 |
라이프에디트 테라퓨틱스, 인크. |
Dna 변형 효소 및 그의 활성 단편 및 변이체 및 사용 방법
|
WO2022056459A1
(en)
|
2020-09-14 |
2022-03-17 |
Vor Biopharma, Inc. |
Compositions and methods for cd5 modification
|
EP4211244A1
(en)
|
2020-09-14 |
2023-07-19 |
Vor Biopharma, Inc. |
Compositions and methods for cd38 modification
|
US11299731B1
(en)
|
2020-09-15 |
2022-04-12 |
Inscripta, Inc. |
CRISPR editing to embed nucleic acid landing pads into genomes of live cells
|
US20240033290A1
(en)
|
2020-09-18 |
2024-02-01 |
Vor Biopharma Inc. |
Compositions and methods for cd7 modification
|
CA3193089A1
(en)
|
2020-09-18 |
2022-03-24 |
Jamie KERSHNER |
Constructs and uses thereof for efficient and specific genome editing
|
WO2022066973A1
(en)
|
2020-09-24 |
2022-03-31 |
Fred Hutchinson Cancer Research Center |
Immunotherapy targeting pbk or oip5 antigens
|
CN116724053A
(zh)
|
2020-09-24 |
2023-09-08 |
弗雷德哈钦森癌症中心 |
靶向sox2抗原的免疫治疗
|
JP2023543218A
(ja)
*
|
2020-09-24 |
2023-10-13 |
フラッグシップ パイオニアリング イノベーションズ ブイ, インコーポレイテッド |
遺伝子発現を阻害するための組成物及び方法
|
JPWO2022064908A1
(sr)
|
2020-09-24 |
2022-03-31 |
|
|
WO2022067240A1
(en)
|
2020-09-28 |
2022-03-31 |
Vor Biopharma, Inc. |
Compositions and methods for cd6 modification
|
WO2022070107A1
(en)
|
2020-09-30 |
2022-04-07 |
Crispr Therapeutics Ag |
Materials and methods for treatment of amyotrophic lateral sclerosis
|
US10947552B1
(en)
|
2020-09-30 |
2021-03-16 |
Alpine Roads, Inc. |
Recombinant fusion proteins for producing milk proteins in plants
|
CA3191387A1
(en)
|
2020-09-30 |
2022-04-07 |
Nobell Foods, Inc. |
Recombinant milk proteins and food compositions comprising the same
|
WO2022072643A1
(en)
|
2020-09-30 |
2022-04-07 |
Vor Biopharma Inc. |
Compositions and methods for cd30 gene modification
|
US10894812B1
(en)
|
2020-09-30 |
2021-01-19 |
Alpine Roads, Inc. |
Recombinant milk proteins
|
US20230348874A1
(en)
|
2020-10-02 |
2023-11-02 |
Limagrain Europe |
Crispr-mediated directed codon re-write
|
US20230375571A1
(en)
|
2020-10-05 |
2023-11-23 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Gdf3 as biomarker and biotarget in post-ischemic cardiac remodeling
|
EP4225914A1
(en)
|
2020-10-06 |
2023-08-16 |
Keygene N.V. |
Targeted sequence addition
|
WO2022076353A1
(en)
|
2020-10-06 |
2022-04-14 |
Fred Hutchinson Cancer Research Center |
Compositions and methods for treating mage-a1-expressing disease
|
WO2022079020A1
(en)
|
2020-10-13 |
2022-04-21 |
Centre National De La Recherche Scientifique (Cnrs) |
Targeted-antibacterial-plasmids combining conjugation and crispr /cas systems and uses thereof
|
KR20230091894A
(ko)
|
2020-10-21 |
2023-06-23 |
메사추세츠 인스티튜트 오브 테크놀로지 |
부위 특이적 표적화 요소를 통한 프로그램 가능한 첨가(paste)를 사용하는 부위 특이적 유전 공학을 위한 시스템, 방법, 및 조성물
|
WO2022084531A1
(en)
|
2020-10-23 |
2022-04-28 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and compositions for treating glioma
|
US20240000846A1
(en)
|
2020-10-27 |
2024-01-04 |
Vor Biopharma Inc. |
Compositions and methods for treating hematopoietic malignancy
|
US20240344058A1
(en)
|
2020-10-30 |
2024-10-17 |
Vor Biopharma Inc. |
Compositions and methods for bcma modification
|
CN112553195B
(zh)
*
|
2020-11-05 |
2022-04-05 |
南方医科大学 |
一种用于CRISPR-Cas9定点突变编辑DNMT1基因的试剂及其应用
|
JPWO2022097663A1
(sr)
|
2020-11-06 |
2022-05-12 |
|
|
US11512297B2
(en)
|
2020-11-09 |
2022-11-29 |
Inscripta, Inc. |
Affinity tag for recombination protein recruitment
|
JP2023549504A
(ja)
|
2020-11-13 |
2023-11-27 |
ノバルティス アーゲー |
キメラ抗原受容体(car)発現細胞との組合せ療法
|
AU2021380830A1
(en)
|
2020-11-13 |
2023-06-08 |
Vor Biopharma Inc. |
Methods and compositions relating to genetically engineered cells expressing chimeric antigen receptors
|
US20230416830A1
(en)
|
2020-11-16 |
2023-12-28 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and compositions for predicting and treating uveal melanoma
|
WO2022112316A1
(en)
|
2020-11-24 |
2022-06-02 |
Keygene N.V. |
Targeted enrichment using nanopore selective sequencing
|
WO2022115506A2
(en)
|
2020-11-24 |
2022-06-02 |
University Of Houston System |
Salicylic acid-inducible gene expression compositions and systems for cells
|
EP4251741A1
(en)
|
2020-11-30 |
2023-10-04 |
CRISPR Therapeutics AG |
Gene-edited natural killer cells
|
WO2022120022A1
(en)
|
2020-12-02 |
2022-06-09 |
Regeneron Pharmaceuticals, Inc. |
Crispr sam biosensor cell lines and methods of use thereof
|
CA3201258A1
(en)
|
2020-12-03 |
2022-06-09 |
Sean Higgins |
Engineered class 2 type v crispr systems
|
WO2022132836A2
(en)
|
2020-12-14 |
2022-06-23 |
Fred Hutchinson Cancer Research Center |
Compositions and methods for cellular immunotherapy
|
BR112023012460A2
(pt)
|
2020-12-23 |
2023-11-07 |
Flagship Pioneering Innovations V Inc |
Conjunto in vitro de capsídeos de anellovirus que envolvem rna
|
TW202235615A
(zh)
|
2020-12-30 |
2022-09-16 |
美商英特利亞醫療公司 |
工程化之t細胞
|
EP4271798A1
(en)
|
2020-12-30 |
2023-11-08 |
CRISPR Therapeutics AG |
Compositions and methods for differentiating stem cells into nk cells
|
WO2022144855A1
(en)
|
2020-12-31 |
2022-07-07 |
Crispr Therapeutics Ag |
Universal donor cells
|
CN116724109A
(zh)
|
2020-12-31 |
2023-09-08 |
Vor生物制药股份有限公司 |
用于cd34基因修饰的组合物和方法
|
WO2022146497A1
(en)
|
2021-01-04 |
2022-07-07 |
Inscripta, Inc. |
Mad nucleases
|
EP4274893B1
(en)
|
2021-01-05 |
2025-01-01 |
Revvity Discovery Limited |
Method for producing genetically modified cells
|
WO2022150269A1
(en)
|
2021-01-07 |
2022-07-14 |
Inscripta, Inc. |
Mad nucleases
|
CA3207102A1
(en)
|
2021-01-12 |
2022-07-21 |
March Therapeutics, Inc. |
Context-dependent, double-stranded dna-specific deaminases and uses thereof
|
EP4288541A1
(en)
|
2021-02-05 |
2023-12-13 |
Christiana Care Gene Editing Institute, Inc. |
Methods of and compositions for reducing gene expression and/or activity
|
AU2022216642A1
(en)
*
|
2021-02-08 |
2023-09-21 |
Emendobio Inc. |
Omni 103 crispr nuclease
|
AU2022215636A1
(en)
*
|
2021-02-08 |
2023-09-21 |
Emendobio Inc. |
Omni 90-99, 101, 104-110, 114, 116, 118-123, 125, 126, 128, 129, and 131-138 crispr nucleases
|
US11884924B2
(en)
|
2021-02-16 |
2024-01-30 |
Inscripta, Inc. |
Dual strand nucleic acid-guided nickase editing
|
CA3207958A1
(en)
|
2021-02-16 |
2022-08-25 |
Julyun OH |
Compositions and methods for treating her2 positive cancers
|
EP4297799A1
(en)
|
2021-02-25 |
2024-01-03 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
Allele-specific genome editing of the nr2e3 mutation g56r
|
US20240141399A1
(en)
*
|
2021-03-01 |
2024-05-02 |
The Regents Of The University Of California |
Methods for generating a crispr array
|
GB202103131D0
(en)
|
2021-03-05 |
2021-04-21 |
Biosystems Tech Limited |
Method for preparation of research organisms
|
EP4308118A1
(en)
|
2021-03-17 |
2024-01-24 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
Methods and compositions for treating melanoma
|
AU2022242754A1
(en)
|
2021-03-22 |
2023-11-02 |
LifeEDIT Therapeutics, Inc. |
Dna modifyng enzymes and active fragments and variants thereof and methods of use
|
TW202309291A
(zh)
|
2021-04-07 |
2023-03-01 |
法商新植物Sas公司 |
用於室內空氣修復之組合物及方法
|
WO2022214522A2
(en)
|
2021-04-07 |
2022-10-13 |
Astrazeneca Ab |
Compositions and methods for site-specific modification
|
US20240200059A1
(en)
|
2021-04-09 |
2024-06-20 |
Vor Biopharma Inc. |
Photocleavable guide rnas and methods of use thereof
|
EP4320153A1
(en)
|
2021-04-09 |
2024-02-14 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for the treatment of anaplastic large cell lymphoma
|
CA3212047A1
(en)
|
2021-04-15 |
2022-10-20 |
Jeroen Stuurman |
Co-regeneration recalcitrant plants
|
JP2024513588A
(ja)
|
2021-04-15 |
2024-03-26 |
キージーン ナムローゼ フェンノートシャップ |
遺伝性突然変異のための可動性エンドヌクレアーゼ
|
EP4323501A1
(en)
|
2021-04-16 |
2024-02-21 |
Beam Therapeutics Inc. |
Genetic modification of hepatocytes
|
EP4326873A1
(en)
|
2021-04-22 |
2024-02-28 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for treating cancer
|
EP4326903A1
(en)
|
2021-04-23 |
2024-02-28 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Methods and compositions for treating cell senescence accumulation related disease
|
CA3218511A1
(en)
|
2021-05-10 |
2022-11-17 |
Sqz Biotechnologies Company |
Methods for delivering genome editing molecules to the nucleus or cytosol of a cell and uses thereof
|
JP2024518793A
(ja)
|
2021-05-27 |
2024-05-02 |
アストラゼネカ・アクチエボラーグ |
向上した安定性を有するcas9エフェクタータンパク質
|
WO2022251644A1
(en)
|
2021-05-28 |
2022-12-01 |
Lyell Immunopharma, Inc. |
Nr4a3-deficient immune cells and uses thereof
|
WO2022254337A1
(en)
|
2021-06-01 |
2022-12-08 |
Novartis Ag |
Cd19 and cd22 chimeric antigen receptors and uses thereof
|
EP4347818A2
(en)
|
2021-06-01 |
2024-04-10 |
Arbor Biotechnologies, Inc. |
Gene editing systems comprising a crispr nuclease and uses thereof
|
EP4419672A2
(en)
|
2021-06-01 |
2024-08-28 |
Artisan Development Labs, Inc. |
Compositions and methods for targeting, editing, or modifying genes
|
EP4347830A2
(en)
|
2021-06-02 |
2024-04-10 |
Beam Therapeutics Inc. |
Circular guide rnas for crispr/cas editing systems
|
US20230052243A1
(en)
|
2021-06-02 |
2023-02-16 |
Lyell Immunopharma, Inc. |
Nr4a-deficient cells expressing c-jun and uses thereof
|
WO2022261115A1
(en)
|
2021-06-07 |
2022-12-15 |
Yale University |
Peptide nucleic acids for spatiotemporal control of crispr-cas binding
|
EP4352215A1
(en)
|
2021-06-11 |
2024-04-17 |
LifeEDIT Therapeutics, Inc. |
Rna polymerase iii promoters and methods of use
|
GB202108585D0
(en)
|
2021-06-16 |
2021-07-28 |
Rockend Ltd |
Methods and compositions
|
CA3223311A1
(en)
|
2021-06-18 |
2022-12-22 |
Andrea BARGHETTI |
Compositions and methods for targeting, editing or modifying human genes
|
WO2022269393A1
(en)
|
2021-06-23 |
2022-12-29 |
Crispr Therapeutics Ag |
Engineered cells with improved protection from natural killer cell killing
|
WO2022272293A1
(en)
*
|
2021-06-23 |
2022-12-29 |
The Board Of Trustees Of The Leland Stanford Junior University |
Compositions and methods for efficient retron production and genetic editing
|
WO2023283585A2
(en)
|
2021-07-06 |
2023-01-12 |
Vor Biopharma Inc. |
Inhibitor oligonucleotides and methods of use thereof
|
WO2023283359A2
(en)
|
2021-07-07 |
2023-01-12 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating secreted frizzled receptor protein 1 (sfrp1) gene expression
|
WO2023283495A1
(en)
*
|
2021-07-09 |
2023-01-12 |
The Brigham And Women's Hospital, Inc. |
Crispr-based protein barcoding and surface assembly
|
TW202317602A
(zh)
|
2021-07-15 |
2023-05-01 |
福瑞德哈金森腫瘤中心 |
嵌合多肽
|
AU2022313315A1
(en)
|
2021-07-23 |
2024-02-08 |
Beam Therapeutics Inc. |
Guide rnas for crispr/cas editing systems
|
CA3227103A1
(en)
|
2021-07-30 |
2023-02-02 |
Matthew P. GEMBERLING |
Compositions and methods for modulating expression of frataxin (fxn)
|
WO2023010135A1
(en)
|
2021-07-30 |
2023-02-02 |
Tune Therapeutics, Inc. |
Compositions and methods for modulating expression of methyl-cpg binding protein 2 (mecp2)
|
EP4381062A1
(en)
|
2021-08-02 |
2024-06-12 |
Vor Biopharma Inc. |
Compositions and methods for gene modification
|
KR102573947B1
(ko)
|
2021-08-09 |
2023-09-01 |
경상국립대학교산학협력단 |
콩 유전자교정 효율 증대를 위한 유전자교정 시스템 및 이의 용도
|
KR102573948B1
(ko)
|
2021-08-09 |
2023-09-01 |
경상국립대학교산학협력단 |
Mips1과 이의 상동체 동시 타겟 유전자교정 시스템 및 이의 용도
|
KR102573952B1
(ko)
|
2021-08-09 |
2023-09-01 |
경상국립대학교산학협력단 |
E2와 이의 상동체 동시 타겟 유전자교정 시스템 및 이의 용도
|
KR102574819B1
(ko)
|
2021-08-09 |
2023-09-04 |
경상국립대학교산학협력단 |
P34와 이의 상동체 동시 타겟 유전자교정 시스템 및 이의 용도
|
KR102584891B1
(ko)
|
2021-08-09 |
2023-10-04 |
경상국립대학교산학협력단 |
GmIPK1 유전자교정 시스템 및 이의 용도
|
EP4144841A1
(en)
*
|
2021-09-07 |
2023-03-08 |
Bayer AG |
Novel small rna programmable endonuclease systems with impoved pam specificity and uses thereof
|
CA3230927A1
(en)
|
2021-09-10 |
2023-03-16 |
Agilent Technologies, Inc. |
Guide rnas with chemical modification for prime editing
|
KR20240095525A
(ko)
*
|
2021-09-21 |
2024-06-25 |
스크라이브 테라퓨틱스 인크. |
조작된 casx 억제 시스템
|
JP2024536851A
(ja)
|
2021-09-27 |
2024-10-08 |
モンサント テクノロジー エルエルシー |
単子葉植物種子から切除された胚外植片を形質転換するための組成物及び方法
|
US20240417755A1
(en)
|
2021-09-27 |
2024-12-19 |
Vor Biopharma Inc. |
Fusion polypeptides for genetic editing and methods of use thereof
|
KR20240082343A
(ko)
|
2021-09-28 |
2024-06-10 |
스미또모 가가꾸 가부시끼가이샤 |
정제 디클로로아세트산의 제조 방법
|
EP4409000A1
(en)
|
2021-09-28 |
2024-08-07 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Base editing approaches for the treatment of beta-hemoglobinopathies
|
JP2024536135A
(ja)
|
2021-09-30 |
2024-10-04 |
アストラゼネカ・アクチエボラーグ |
CRISPR/Cas挿入の効率を増大させるための阻害剤の使用
|
CA3233097A1
(en)
|
2021-09-30 |
2023-04-06 |
Katherine Diane GRIBBLE |
Compositions and methods for treating kcnq4-associated hearing loss
|
WO2023059115A1
(ko)
|
2021-10-06 |
2023-04-13 |
주식회사 진코어 |
유전자 편집을 위한 target 시스템 및 이의 용도
|
WO2023064924A1
(en)
|
2021-10-14 |
2023-04-20 |
Codiak Biosciences, Inc. |
Modified producer cells for extracellular vesicle production
|
AU2022366987A1
(en)
|
2021-10-14 |
2024-05-16 |
Arsenal Biosciences, Inc. |
Immune cells having co-expressed shrnas and logic gate systems
|
WO2023064732A1
(en)
|
2021-10-15 |
2023-04-20 |
Georgia State University Research Foundation, Inc. |
Delivery of therapeutic recombinant uricase using nanoparticles
|
JP2024540972A
(ja)
|
2021-10-20 |
2024-11-06 |
ユニバーシティ オブ ロチェスター |
加齢性白質喪失の若返り治療
|
WO2023070043A1
(en)
|
2021-10-20 |
2023-04-27 |
Yale University |
Compositions and methods for targeted editing and evolution of repetitive genetic elements
|
US20240407344A1
(en)
|
2021-10-22 |
2024-12-12 |
Tokyo Metropolitan Institute Of Medical Science |
Neurodegenerative and amyotrophic model animal
|
US20230293727A1
(en)
|
2021-10-26 |
2023-09-21 |
Regeneron Pharmaceuticals, Inc. |
Overexpression of lemd2, lemd3, or chmp7 as a therapeutic modality for tauopathy
|
TW202334194A
(zh)
|
2021-10-27 |
2023-09-01 |
美商雷傑納榮製藥公司 |
用於表現因子ix以便治療b型血友病的組成物及方法
|
EP4423271A2
(en)
|
2021-10-28 |
2024-09-04 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas-related methods and compositions for knocking out c5
|
MX2024005318A
(es)
|
2021-11-01 |
2024-09-23 |
Tome Biosciences Inc |
Plataforma de construccion unica para el suministro simultaneo de maquinaria de edicion de genes y carga de acido nucleico.
|
WO2023081756A1
(en)
|
2021-11-03 |
2023-05-11 |
The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone |
Precise genome editing using retrons
|
EP4427044A1
(en)
|
2021-11-03 |
2024-09-11 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
Methods and compositions for treating triple negative breast cancer (tnbc)
|
CN118488784A
(zh)
|
2021-11-04 |
2024-08-13 |
瑞泽恩制药公司 |
包含经修饰的cacng1基因座的非人动物
|
CA3236152A1
(en)
|
2021-11-09 |
2023-05-19 |
Vor Biopharma Inc. |
Compositions and methods for erm2 modification
|
WO2023091954A2
(en)
|
2021-11-19 |
2023-05-25 |
The Trustees Of The University Of Pennsylvania |
Engineered pan-leukocyte antigen cd45 to facilitate car t cell therapy
|
GB202117314D0
(en)
|
2021-11-30 |
2022-01-12 |
Clarke David John |
Cyclic nucleic acid fragmentation
|
EP4441089A1
(en)
|
2021-12-01 |
2024-10-09 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for increasing fetal hemoglobin content by editing the +55-kb region of the erythroid-specific bcl11a enhancer
|
CN118632622A
(zh)
|
2021-12-08 |
2024-09-10 |
瑞泽恩制药公司 |
突变型肌纤蛋白疾病模型及其用途
|
EP4444874A1
(en)
|
2021-12-09 |
2024-10-16 |
Zygosity Limited |
Vector
|
WO2023105244A1
(en)
|
2021-12-10 |
2023-06-15 |
Pig Improvement Company Uk Limited |
Editing tmprss2/4 for disease resistance in livestock
|
US20230193310A1
(en)
|
2021-12-10 |
2023-06-22 |
Seminis Vegetabe Seeds, Inc. |
Lettuce plants having resistance to downy mildew
|
GB202118058D0
(en)
|
2021-12-14 |
2022-01-26 |
Univ Warwick |
Methods to increase yields in crops
|
US20230279442A1
(en)
|
2021-12-15 |
2023-09-07 |
Versitech Limited |
Engineered cas9-nucleases and method of use thereof
|
WO2023111173A1
(en)
|
2021-12-16 |
2023-06-22 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
An ezh2 degrader or inhibitor for use in the treatment of resistant acute myeloid leukemia
|
JP2025500904A
(ja)
|
2021-12-17 |
2025-01-15 |
キージーン ナムローゼ フェンノートシャップ |
植物の二重摘心
|
WO2023122506A1
(en)
|
2021-12-20 |
2023-06-29 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising humanized ace2 and tmprss loci
|
EP4453196A1
(en)
|
2021-12-21 |
2024-10-30 |
Alia Therapeutics Srl |
Type ii cas proteins and applications thereof
|
WO2023119135A1
(en)
|
2021-12-21 |
2023-06-29 |
Benson Hill, Inc. |
Compositions and methods for modifying genomes
|
EP4452257A1
(en)
|
2021-12-21 |
2024-10-30 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and compositions for treating melanoma
|
EP4452335A1
(en)
|
2021-12-22 |
2024-10-30 |
Tome Biosciences, Inc. |
Co-delivery of a gene editor construct and a donor template
|
IL313726A
(en)
|
2021-12-23 |
2024-08-01 |
Univ Massachusetts |
Medical treatment of fragile X-linked disorder
|
AU2022424002A1
(en)
|
2021-12-29 |
2024-06-13 |
Bristol-Myers Squibb Company |
Generation of landing pad cell lines
|
WO2023137471A1
(en)
|
2022-01-14 |
2023-07-20 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for programming t cell phenotypes through targeted gene activation
|
WO2023137472A2
(en)
|
2022-01-14 |
2023-07-20 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for programming t cell phenotypes through targeted gene repression
|
WO2023141602A2
(en)
|
2022-01-21 |
2023-07-27 |
Renagade Therapeutics Management Inc. |
Engineered retrons and methods of use
|
WO2023139557A1
(en)
|
2022-01-24 |
2023-07-27 |
LifeEDIT Therapeutics, Inc. |
Rna-guided nucleases and active fragments and variants thereof and methods of use
|
WO2023144104A1
(en)
|
2022-01-25 |
2023-08-03 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Base editing approaches for the treatment of βeta-thalassemia
|
WO2023144235A1
(en)
|
2022-01-27 |
2023-08-03 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for monitoring and treating warburg effect in patients with pi3k-related disorders
|
WO2023150181A1
(en)
|
2022-02-01 |
2023-08-10 |
President And Fellows Of Harvard College |
Methods and compositions for treating cancer
|
AU2023216255A1
(en)
|
2022-02-02 |
2024-07-11 |
Regeneron Pharmaceuticals, Inc. |
Anti-tfr:gaa and anti-cd63:gaa insertions for treatment of pompe disease
|
EP4475671A1
(en)
|
2022-02-07 |
2024-12-18 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for defining optimal treatment timeframes in lysosomal disease
|
EP4223877A1
(en)
*
|
2022-02-08 |
2023-08-09 |
Eberhard Karls Universität Tübingen Medizinische Fakultät |
System and method for editing genomic dna to modulate splicing
|
IL314673A
(en)
|
2022-02-11 |
2024-10-01 |
Regeneron Pharma |
Compositions and methods for screening 4r tau targeting agents
|
WO2023152351A1
(en)
|
2022-02-14 |
2023-08-17 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Treatment of liver cancers by disrupting the beta-catenin/tcf-4 binding site located upstream of meg3 in the dlk1/dio3 locus
|
EP4479536A1
(en)
|
2022-02-17 |
2024-12-25 |
The Board Of Regents Of The University Of Texas System |
Crispr/spcas9 variant and methods for enhanced correcton of duchenne muscular dystrophy mutations
|
WO2023156587A1
(en)
|
2022-02-18 |
2023-08-24 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Use of tcr-deficient car-tregs in combination with anti-tcr complex monoclonal antibodies for inducing durable tolerance
|
AU2022201166B2
(en)
*
|
2022-02-21 |
2024-02-22 |
Zhuhai Shu Tong Medical Technology Co., Ltd. |
Type ii crispr/cas9 genome editing system and the application thereof
|
US12157886B2
(en)
*
|
2022-02-21 |
2024-12-03 |
Zhuhai Shu Tong Medical Technology Co., Ltd. |
Type II CRISPR/Cas9 genome editing system and the application thereof
|
WO2023164670A2
(en)
*
|
2022-02-25 |
2023-08-31 |
Duke University |
Crispr-cas9 compositions and methods with a novel cas9 protein for genome editing and gene regulation
|
WO2023164636A1
(en)
|
2022-02-25 |
2023-08-31 |
Vor Biopharma Inc. |
Compositions and methods for homology-directed repair gene modification
|
CN119032176A
(zh)
|
2022-03-01 |
2024-11-26 |
克里斯珀医疗股份公司 |
用于治疗血管生成素样3 (angptl3)相关状况的方法和组合物
|
EP4486881A1
(en)
|
2022-03-01 |
2025-01-08 |
Celyntra Therapeutics SA |
Composition and methods for transgene insertion
|
JPWO2023182274A1
(sr)
|
2022-03-23 |
2023-09-28 |
|
|
WO2023192872A1
(en)
|
2022-03-28 |
2023-10-05 |
Massachusetts Institute Of Technology |
Rna scaffolded wireframe origami and methods thereof
|
WO2023194359A1
(en)
|
2022-04-04 |
2023-10-12 |
Alia Therapeutics Srl |
Compositions and methods for treatment of usher syndrome type 2a
|
AU2023251040A1
(en)
|
2022-04-04 |
2024-10-17 |
Vor Biopharma Inc. |
Compositions and methods for mediating epitope engineering
|
WO2023205744A1
(en)
|
2022-04-20 |
2023-10-26 |
Tome Biosciences, Inc. |
Programmable gene insertion compositions
|
CN114864002B
(zh)
*
|
2022-04-28 |
2023-03-10 |
广西科学院 |
一种基于深度学习的转录因子结合位点识别方法
|
WO2023212677A2
(en)
|
2022-04-29 |
2023-11-02 |
Regeneron Pharmaceuticals, Inc. |
Identification of tissue-specific extragenic safe harbors for gene therapy approaches
|
IL316555A
(en)
|
2022-05-02 |
2024-12-01 |
Fond Telethon Ets |
Homology-independent directed integration for gene editing
|
WO2023215725A1
(en)
|
2022-05-02 |
2023-11-09 |
Fred Hutchinson Cancer Center |
Compositions and methods for cellular immunotherapy
|
WO2023215831A1
(en)
|
2022-05-04 |
2023-11-09 |
Tome Biosciences, Inc. |
Guide rna compositions for programmable gene insertion
|
WO2023220603A1
(en)
|
2022-05-09 |
2023-11-16 |
Regeneron Pharmaceuticals, Inc. |
Vectors and methods for in vivo antibody production
|
WO2023217888A1
(en)
|
2022-05-10 |
2023-11-16 |
Institut National de la Santé et de la Recherche Médicale |
Base editing approaches for correcting the cd39 (cag>tag) mutation in patients suffering from βeta-thalassemia
|
CN119183383A
(zh)
*
|
2022-05-13 |
2024-12-24 |
思研(Sri)国际顾问与咨询公司 |
转录因子到内源基因的可编程募集
|
AU2023273885A1
(en)
|
2022-05-19 |
2024-12-05 |
Lyell Immunopharma, Inc. |
Polynucleotides targeting nr4a3 and uses thereof
|
WO2023225670A2
(en)
|
2022-05-20 |
2023-11-23 |
Tome Biosciences, Inc. |
Ex vivo programmable gene insertion
|
WO2023225410A2
(en)
|
2022-05-20 |
2023-11-23 |
Artisan Development Labs, Inc. |
Systems and methods for assessing risk of genome editing events
|
AU2023276715A1
(en)
|
2022-05-25 |
2025-01-09 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and methods for modulating circulating factors
|
WO2023230566A2
(en)
|
2022-05-25 |
2023-11-30 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and methods for modulating cytokines
|
AU2023276757A1
(en)
|
2022-05-25 |
2024-11-21 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and methods for modulation of tumor suppressors and oncogenes
|
WO2023230570A2
(en)
|
2022-05-25 |
2023-11-30 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and methods for modulating genetic drivers
|
AU2023276714A1
(en)
|
2022-05-25 |
2024-11-21 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and methods for modulation of immune responses
|
WO2023235726A2
(en)
|
2022-05-31 |
2023-12-07 |
Regeneron Pharmaceuticals, Inc. |
Crispr interference therapeutics for c9orf72 repeat expansion disease
|
WO2023235677A1
(en)
|
2022-05-31 |
2023-12-07 |
Regeneron Pharmaceuticals, Inc. |
Animal model of tdp-43 proteinopathy
|
WO2023235725A2
(en)
|
2022-05-31 |
2023-12-07 |
Regeneron Pharmaceuticals, Inc. |
Crispr-based therapeutics for c9orf72 repeat expansion disease
|
WO2023233339A1
(en)
|
2022-06-01 |
2023-12-07 |
Crispr Therapeutics Ag |
Compositions and methods for differentiating stem cells into nk cells
|
WO2023233342A2
(en)
|
2022-06-01 |
2023-12-07 |
Crispr Therapeutics Ag |
Gene-edited natural killer cells
|
US20230404003A1
(en)
|
2022-06-21 |
2023-12-21 |
Seminis Vegetable Seeds, Inc. |
Novel qtls conferring resistance to cucumber mosaic virus
|
WO2023250511A2
(en)
|
2022-06-24 |
2023-12-28 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for reducing low-density lipoprotein through targeted gene repression
|
WO2024006955A1
(en)
|
2022-06-29 |
2024-01-04 |
Intellia Therapeutics, Inc. |
Engineered t cells
|
GB202209518D0
(en)
|
2022-06-29 |
2022-08-10 |
Snipr Biome Aps |
Treating & preventing E coli infections
|
WO2024005864A1
(en)
|
2022-06-30 |
2024-01-04 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
JP7152094B1
(ja)
|
2022-06-30 |
2022-10-12 |
リージョナルフィッシュ株式会社 |
tracrRNAユニット、及びゲノム編集方法
|
WO2024005863A1
(en)
|
2022-06-30 |
2024-01-04 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
WO2024006802A1
(en)
|
2022-06-30 |
2024-01-04 |
Pioneer Hi-Bred International, Inc. |
Artificial intelligence-mediated methods and systems for genome editing
|
EP4299739A1
(en)
|
2022-06-30 |
2024-01-03 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
EP4299733A1
(en)
|
2022-06-30 |
2024-01-03 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
GB2621813A
(en)
|
2022-06-30 |
2024-02-28 |
Univ Newcastle |
Preventing disease recurrence in Mitochondrial replacement therapy
|
WO2024008799A1
(en)
|
2022-07-06 |
2024-01-11 |
Institut National de la Santé et de la Recherche Médicale |
Methods for the treatment of proliferative glomerulonephritis
|
WO2024015881A2
(en)
|
2022-07-12 |
2024-01-18 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for targeted transcriptional activation
|
WO2024015925A2
(en)
|
2022-07-13 |
2024-01-18 |
Vor Biopharma Inc. |
Compositions and methods for artificial protospacer adjacent motif (pam) generation
|
WO2024013514A2
(en)
|
2022-07-15 |
2024-01-18 |
Pig Improvement Company Uk Limited |
Gene edited livestock animals having coronavirus resistance
|
AU2023311964A1
(en)
|
2022-07-18 |
2025-01-30 |
Renagade Therapeutics Management Inc. |
Gene editing components, systems, and methods of use
|
WO2024020587A2
(en)
|
2022-07-22 |
2024-01-25 |
Tome Biosciences, Inc. |
Pleiopluripotent stem cell programmable gene insertion
|
WO2024018056A1
(en)
|
2022-07-22 |
2024-01-25 |
Institut National de la Santé et de la Recherche Médicale |
Base editing approaches for correcting the ivs2-1 (g>a) mutation in patients suffering from βeta-thalassemia
|
AU2023311477A1
(en)
|
2022-07-22 |
2025-01-30 |
The Johns Hopkins University |
Dendrimer-enabled targeted intracellular crispr/cas system delivery and gene editing
|
WO2024026313A1
(en)
|
2022-07-25 |
2024-02-01 |
The Regents Of The University Of California |
Methods of producing and using avian embryonic stem cells and avian telencephalic organoids
|
WO2024023734A1
(en)
|
2022-07-26 |
2024-02-01 |
Bit Bio Limited |
MULTI-gRNA GENOME EDITING
|
WO2024024873A1
(ja)
|
2022-07-28 |
2024-02-01 |
住友化学株式会社 |
チオ化溶液
|
WO2024026474A1
(en)
|
2022-07-29 |
2024-02-01 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle
|
WO2024026488A2
(en)
|
2022-07-29 |
2024-02-01 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a modified transferrin receptor locus
|
WO2024028433A1
(en)
|
2022-08-04 |
2024-02-08 |
Institut National de la Santé et de la Recherche Médicale |
Methods for the treatment of lymphoproliferative disorders
|
AU2023320529A1
(en)
|
2022-08-05 |
2025-02-06 |
Regeneron Pharmaceuticals, Inc. |
Aggregation-resistant variants of tdp-43
|
WO2024036190A2
(en)
|
2022-08-09 |
2024-02-15 |
Pioneer Hi-Bred International, Inc. |
Guide polynucleotide multiplexing
|
WO2024033901A1
(en)
|
2022-08-12 |
2024-02-15 |
LifeEDIT Therapeutics, Inc. |
Rna-guided nucleases and active fragments and variants thereof and methods of use
|
TW202426641A
(zh)
|
2022-08-19 |
2024-07-01 |
美商圖恩療法股份有限公司 |
以靶向基因抑制來調節b型肝炎病毒之組合物、系統和方法
|
WO2024044723A1
(en)
|
2022-08-25 |
2024-02-29 |
Renagade Therapeutics Management Inc. |
Engineered retrons and methods of use
|
WO2024042489A1
(en)
|
2022-08-25 |
2024-02-29 |
LifeEDIT Therapeutics, Inc. |
Chemical modification of guide rnas with locked nucleic acid for rna guided nuclease-mediated gene editing
|
WO2024042165A2
(en)
|
2022-08-26 |
2024-02-29 |
UCB Biopharma SRL |
Novel rna-guided nucleases and nucleic acid targeting systems comprising such rna-guided nucleases
|
WO2024042168A1
(en)
|
2022-08-26 |
2024-02-29 |
UCB Biopharma SRL |
Novel rna-guided nucleases and nucleic acid targeting systems comprising such rna-guided nucleases
|
WO2024047110A1
(en)
|
2022-08-31 |
2024-03-07 |
Institut National de la Santé et de la Recherche Médicale |
Method to generate more efficient car-t cells
|
WO2024047247A1
(en)
|
2022-09-02 |
2024-03-07 |
Institut National de la Santé et de la Recherche Médicale |
Base editing approaches for the treatment of amyotrophic lateral sclerosis
|
WO2024052318A1
(en)
|
2022-09-06 |
2024-03-14 |
Institut National de la Santé et de la Recherche Médicale |
Novel dual split car-t cells for the treatment of cd38-positive hematological malignancies
|
WO2024056659A1
(en)
|
2022-09-13 |
2024-03-21 |
Institut National de la Santé et de la Recherche Médicale |
Method for treating prostate cancer and other epithelial cancers
|
WO2024056880A2
(en)
|
2022-09-16 |
2024-03-21 |
Alia Therapeutics Srl |
Enqp type ii cas proteins and applications thereof
|
WO2024064623A2
(en)
*
|
2022-09-19 |
2024-03-28 |
Emendobio Inc. |
Biallelic knockout of cish
|
WO2024064642A2
(en)
|
2022-09-19 |
2024-03-28 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for modulating t cell function
|
WO2024064824A2
(en)
|
2022-09-21 |
2024-03-28 |
Yale University |
Compositions and methods for identification of membrane targets for enhancement of nk cell therapy
|
WO2024064952A1
(en)
|
2022-09-23 |
2024-03-28 |
Lyell Immunopharma, Inc. |
Methods for culturing nr4a-deficient cells overexpressing c-jun
|
WO2024064958A1
(en)
|
2022-09-23 |
2024-03-28 |
Lyell Immunopharma, Inc. |
Methods for culturing nr4a-deficient cells
|
WO2024073606A1
(en)
|
2022-09-28 |
2024-04-04 |
Regeneron Pharmaceuticals, Inc. |
Antibody resistant modified receptors to enhance cell-based therapies
|
US20240224964A9
(en)
|
2022-09-29 |
2024-07-11 |
Regeneron Pharmaceuticals, Inc. |
Correction of hepatosteatosis in humanized liver animals through restoration of il6/il6r/gp130 signaling in human hepatocytes
|
WO2024073751A1
(en)
|
2022-09-29 |
2024-04-04 |
Vor Biopharma Inc. |
Methods and compositions for gene modification and enrichment
|
WO2024077174A1
(en)
|
2022-10-05 |
2024-04-11 |
Lyell Immunopharma, Inc. |
Methods for culturing nr4a-deficient cells
|
WO2024081736A2
(en)
|
2022-10-11 |
2024-04-18 |
Yale University |
Compositions and methods of using cell-penetrating antibodies
|
WO2024083579A1
(en)
|
2022-10-20 |
2024-04-25 |
Basf Se |
Regulatory nucleic acid molecules for enhancing gene expression in plants
|
WO2024084034A1
(en)
|
2022-10-21 |
2024-04-25 |
Institut National de la Santé et de la Recherche Médicale |
Methods and pharmaceutical compositions for the treatment of osteoarthritis
|
EP4477659A1
(en)
|
2022-10-27 |
2024-12-18 |
Sumitomo Chemical Company, Limited |
Method for producing oligonucleotide
|
CN115678903B
(zh)
*
|
2022-11-03 |
2024-04-02 |
贵州大学 |
一种白背飞虱Ago1基因、合成dsRNA的方法及其应用
|
TW202434726A
(zh)
|
2022-11-04 |
2024-09-01 |
美商生命編輯治療學公司 |
具內部插入位進化腺嘌呤去胺及rna引導之核酸酶融合蛋白及其使用方法
|
US20240182561A1
(en)
|
2022-11-04 |
2024-06-06 |
Regeneron Pharmaceuticals, Inc. |
Calcium voltage-gated channel auxiliary subunit gamma 1 (cacng1) binding proteins and cacng1-mediated delivery to skeletal muscle
|
WO2024102434A1
(en)
|
2022-11-10 |
2024-05-16 |
Senda Biosciences, Inc. |
Rna compositions comprising lipid nanoparticles or lipid reconstructed natural messenger packs
|
US20240173426A1
(en)
|
2022-11-14 |
2024-05-30 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes
|
WO2024107670A1
(en)
|
2022-11-16 |
2024-05-23 |
Regeneron Pharmaceuticals, Inc. |
Chimeric proteins comprising membrane bound il-12 with protease cleavable linkers
|
WO2024105162A1
(en)
|
2022-11-16 |
2024-05-23 |
Alia Therapeutics Srl |
Type ii cas proteins and applications thereof
|
WO2024105633A1
(en)
|
2022-11-18 |
2024-05-23 |
Kyoto Prefectural Public University Corporation |
Compositions for mitophagy induction and uses thereof
|
WO2024119101A1
(en)
|
2022-12-01 |
2024-06-06 |
Yale University |
Stimuli-responsive traceless engineering platform for intracellular payload delivery
|
WO2024118882A1
(en)
|
2022-12-01 |
2024-06-06 |
Genencor International Bv |
Iterative multiplex genome engineering in microbial cells using a selection marker swapping system
|
WO2024118876A1
(en)
|
2022-12-01 |
2024-06-06 |
Genencor International Bv |
Iterative multiplex genome engineering in microbial cells using a recombinant self-excisable selection marker system
|
WO2024118881A1
(en)
|
2022-12-01 |
2024-06-06 |
Genencor International Bv |
Iterative muliplex genome engineering in microbial cells using a bidirectional selection marker system
|
WO2024123786A1
(en)
|
2022-12-06 |
2024-06-13 |
Pioneer Hi-Bred International, Inc. |
Methods and compositions for co-delivery of t-dnas expressing multiple guide polynucleotides into plants
|
WO2024123789A1
(en)
|
2022-12-07 |
2024-06-13 |
Sanofi |
Predicting indel frequencies
|
WO2024127370A1
(en)
|
2022-12-16 |
2024-06-20 |
LifeEDIT Therapeutics, Inc. |
Guide rnas that target trac gene and methods of use
|
WO2024127369A1
(en)
|
2022-12-16 |
2024-06-20 |
LifeEDIT Therapeutics, Inc. |
Guide rnas that target foxp3 gene and methods of use
|
WO2024138194A1
(en)
|
2022-12-22 |
2024-06-27 |
Tome Biosciences, Inc. |
Platforms, compositions, and methods for in vivo programmable gene insertion
|
WO2024133723A1
(en)
|
2022-12-22 |
2024-06-27 |
Institut National de la Santé et de la Recherche Médicale |
Methods for decreasing therapeutic acquired resistance to chemotherapy and/or radiotherapy
|
WO2024138189A2
(en)
|
2022-12-22 |
2024-06-27 |
Intellia Therapeutics, Inc. |
Methods for analyzing nucleic acid cargos of lipid nucleic acid assemblies
|
WO2024133851A1
(en)
|
2022-12-22 |
2024-06-27 |
Keygene N.V. |
Regeneration by protoplast callus grafting
|
WO2024149810A2
(en)
|
2023-01-11 |
2024-07-18 |
Alia Therapeutics Srl |
Type ii cas proteins and applications thereof
|
WO2024151213A2
(en)
|
2023-01-12 |
2024-07-18 |
National University Of Singapore |
Blockade of cd8 expression and chimeric antigen receptors for immunotherapy of t-cell and nk-cell malignancies
|
WO2024159071A1
(en)
|
2023-01-27 |
2024-08-02 |
Regeneron Pharmaceuticals, Inc. |
Modified rhabdovirus glycoproteins and uses thereof
|
WO2024163650A1
(en)
|
2023-02-01 |
2024-08-08 |
Regeneron Pharmaceuticals, Inc. |
Animals comprising a modified klhdc7b locus
|
WO2024163678A2
(en)
|
2023-02-01 |
2024-08-08 |
Tune Therapeutics, Inc. |
Fusion proteins and systems for targeted activation of frataxin (fxn) and related methods
|
WO2024163683A2
(en)
|
2023-02-01 |
2024-08-08 |
Tune Therapeutics, Inc. |
Systems, compositions, and methods for modulating expression of methyl-cpg binding protein 2 (mecp2) and x-inactive specific transcript (xist)
|
WO2024163615A1
(en)
|
2023-02-02 |
2024-08-08 |
University Of Florida Research Foundation, Incorporated |
Brain-derived neurotrophic factor-nano luciferase transgenic rodents and methods of use thereof
|
WO2024165484A1
(en)
|
2023-02-06 |
2024-08-15 |
Institut National de la Santé et de la Recherche Médicale |
Enrichment of genetically modified hematopoietic stem cells through multiplex base editing
|
WO2024168097A2
(en)
*
|
2023-02-07 |
2024-08-15 |
Applied Stemcell, Inc. |
Integrase variants for gene insertion in human cell
|
WO2024168312A1
(en)
|
2023-02-09 |
2024-08-15 |
Vor Biopharma Inc. |
Methods for treating hematopoietic malignancy
|
WO2024168348A1
(en)
*
|
2023-02-10 |
2024-08-15 |
Tryptagenix, Inc. |
Production of monoterpene indole alkaloid compounds in a heterologous host
|
US20240301447A1
(en)
|
2023-02-15 |
2024-09-12 |
Arbor Biotechnologies, Inc. |
Gene editing method for inhibiting aberrant splicing in stathmin 2 (stmn2) transcript
|
WO2024184376A1
(en)
|
2023-03-09 |
2024-09-12 |
International Centre For Genetic Engineering And Biotechnology - Icgeb |
Human alpha galactosidase a coding sequence for the treatment of fabry disease
|
WO2024196921A1
(en)
|
2023-03-20 |
2024-09-26 |
Pioneer Hi-Bred International, Inc. |
Cas polypeptides with altered pam recognition
|
US20240358820A1
(en)
|
2023-03-23 |
2024-10-31 |
Carbon Biosciences, Inc. |
Protoparvovirus compositions comprising a protoparvovirus variant vp1 capsid polypeptide and related methods
|
WO2024196965A1
(en)
|
2023-03-23 |
2024-09-26 |
Carbon Biosciences, Inc. |
Parvovirus compositions and related methods for gene therapy
|
WO2024201368A1
(en)
|
2023-03-29 |
2024-10-03 |
Astrazeneca Ab |
Use of inhibitors to increase efficiency of crispr/cas insertions
|
WO2024206911A2
(en)
|
2023-03-30 |
2024-10-03 |
Children's Hospital Medical Center |
Clinical-grade organoids
|
WO2024206714A1
(en)
*
|
2023-03-31 |
2024-10-03 |
Mammoth Biosciences, Inc. |
Engineered effector proteins, compositions, systems and methods of use thereof
|
WO2024211287A1
(en)
|
2023-04-03 |
2024-10-10 |
Seagen Inc. |
Production cell lines with targeted integration sites
|
WO2024211887A1
(en)
*
|
2023-04-07 |
2024-10-10 |
Genentech, Inc. |
Modified guide rnas
|
WO2024215744A1
(en)
|
2023-04-14 |
2024-10-17 |
Seminis Vegetable Seeds, Inc. |
Methods and compositions for peronospora resistance in spinach
|
WO2024220135A1
(en)
|
2023-04-17 |
2024-10-24 |
University Of Massachusetts |
Prime editing systems having pegrna with reduced auto-inhibitory interaction
|
WO2024218295A1
(en)
|
2023-04-21 |
2024-10-24 |
Vib Vzw |
Allelic combinations in crops for yield increase
|
WO2024218394A1
(en)
|
2023-04-21 |
2024-10-24 |
Fondazione Telethon Ets |
Genome editing methods and constructs
|
WO2024226499A1
(en)
|
2023-04-24 |
2024-10-31 |
The Broad Institute, Inc. |
Compositions and methods for modifying fertility
|
WO2024227131A1
(en)
*
|
2023-04-27 |
2024-10-31 |
Rensselaer Polytechnic Institute |
Recombinant enzyme for the accurate insertion of dna sequences in eukaryotic cells
|
WO2024226156A1
(en)
|
2023-04-27 |
2024-10-31 |
University Of Massachusetts |
Cas-embedded cytidine deaminase ribonucleoprotein complexes having improved base editing specificity and efficiency
|
WO2024233328A1
(en)
*
|
2023-05-05 |
2024-11-14 |
Insmed Incorporated |
Nannochloropsis-producing viruses and methods and compositions for making the same
|
WO2024234006A1
(en)
|
2023-05-11 |
2024-11-14 |
Tome Biosciences, Inc. |
Systems, compositions, and methods for targeting liver sinusodial endothelial cells (lsecs)
|
WO2024233894A1
(en)
*
|
2023-05-11 |
2024-11-14 |
University Of Massachusetts |
Compositions and methods for improved genome editing with nme2cas9 and nme2-smucas9 variants
|
WO2024235991A1
(en)
|
2023-05-15 |
2024-11-21 |
UCB Biopharma SRL |
Rna-guided nucleases and nucleic acid targeting systems comprising such rna-guided nucleases
|
WO2024236336A1
(en)
|
2023-05-17 |
2024-11-21 |
Institut National de la Santé et de la Recherche Médicale |
Lipc variant in the treatment of hypercholesterolemia and atherosclerotic cardiovascular disease
|
WO2024238977A2
(en)
|
2023-05-18 |
2024-11-21 |
Children's Hospital Medical Center |
Liver organoids with intrahepatic sympathetic nerves, and methods of use thereof
|
WO2024243438A2
(en)
|
2023-05-23 |
2024-11-28 |
Omega Therapeutics, Inc. |
Compositions and methods for reducing cxcl9, cxcl10, and cxcl11 gene expression
|
WO2024245951A1
(en)
|
2023-05-26 |
2024-12-05 |
Institut National de la Santé et de la Recherche Médicale |
Combination of slc8a1 inhibitor and mitochondria-targeted antioxidant for treating melanoma
|
WO2024246162A1
(en)
|
2023-05-30 |
2024-12-05 |
Institut National de la Santé et de la Recherche Médicale |
Method and pharmaceutical composition for use in the treatment of focal cortical dysplasia
|
WO2024254376A1
(en)
|
2023-06-08 |
2024-12-12 |
Regeneron Pharmaceuticals, Inc. |
Animal model with rapid onset of alzheimer's amyloid beta plaque pathology
|
WO2024259135A1
(en)
|
2023-06-13 |
2024-12-19 |
Intellia Therapeutics, Inc. |
Assays for analysis of ribonucleic acid (rna) molecules
|
WO2024256635A1
(en)
|
2023-06-15 |
2024-12-19 |
Institut National de la Santé et de la Recherche Médicale |
Dpm1 inhibitor for treating cancer
|
WO2024259309A1
(en)
|
2023-06-15 |
2024-12-19 |
Regeneron Pharmaceuticals, Inc. |
Gene therapy for hearing disorders
|
WO2024261302A1
(en)
|
2023-06-22 |
2024-12-26 |
Institut National de la Santé et de la Recherche Médicale |
Nlrp3 inhibitors, pak1/2 inhibitors and/or caspase 1 inhibitors for use in the treatment of rac2 monogenic disorders
|
WO2024261323A1
(en)
|
2023-06-23 |
2024-12-26 |
Astrazeneca Ab |
Molecular switches
|
WO2024263961A2
(en)
|
2023-06-23 |
2024-12-26 |
Children's Hospital Medical Center |
Methods of matrix-free suspension culture
|
WO2025003344A1
(en)
|
2023-06-28 |
2025-01-02 |
Alia Therapeutics Srl |
Type ii cas proteins and applications thereof
|
WO2025006963A1
(en)
|
2023-06-30 |
2025-01-02 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for increasing homology-directed repair
|
WO2025012316A2
(en)
|
2023-07-10 |
2025-01-16 |
Universiteit Gent |
Method of genome-editing
|
WO2025017033A1
(en)
|
2023-07-17 |
2025-01-23 |
Institut National de la Santé et de la Recherche Médicale |
Prime editing of the -115 region in the hbg1 and/or hbg2 promoter for increasing fetal hemoglobin content in a eukaryotic cell
|
WO2025017030A1
(en)
|
2023-07-17 |
2025-01-23 |
Institut National de la Santé et de la Recherche Médicale |
Prime editing of the -200 region in the hbg1 and/or hbg2 promoter for increasing fetal hemoglobin content in a eukaryotic cell
|
WO2025021839A1
(en)
|
2023-07-25 |
2025-01-30 |
Institut National de la Santé et de la Recherche Médicale |
Method to treat metabolic disorders
|
WO2025022367A2
(en)
|
2023-07-27 |
2025-01-30 |
Life Edit Therapeutics, Inc. |
Rna-guided nucleases and active fragments and variants thereof and methods of use
|
CN118127022B
(zh)
*
|
2024-04-30 |
2024-07-12 |
四川大学 |
变异链球菌环状RNA circcsbD及应用、其过表达菌株及构建方法和应用
|