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DK2342226T3 - HUMAN ANTI-PD-1, PD-L1 AND PD-L2 ANTIBODIES AND APPLICATIONS THEREOF - Google Patents

HUMAN ANTI-PD-1, PD-L1 AND PD-L2 ANTIBODIES AND APPLICATIONS THEREOF Download PDF

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Publication number
DK2342226T3
DK2342226T3 DK09816950.1T DK09816950T DK2342226T3 DK 2342226 T3 DK2342226 T3 DK 2342226T3 DK 09816950 T DK09816950 T DK 09816950T DK 2342226 T3 DK2342226 T3 DK 2342226T3
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Prior art keywords
antibody
antigen
antibodies
cells
human
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DK09816950.1T
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Danish (da)
English (en)
Inventor
Rafi Ahmed
James P Gregson
Gordon J Freeman
Timothy D Jones
Francis J Carr
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Dana Farber Cancer Inst Inc
Univ Emory
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Publication of DK2342226T3 publication Critical patent/DK2342226T3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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  • Immunology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
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  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
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DK09816950.1T 2008-09-26 2009-09-25 HUMAN ANTI-PD-1, PD-L1 AND PD-L2 ANTIBODIES AND APPLICATIONS THEREOF DK2342226T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10053408P 2008-09-26 2008-09-26
PCT/US2009/058475 WO2010036959A2 (en) 2008-09-26 2009-09-25 Human anti-pd-1, pd-l1, and pd-l2 antibodies and uses therefor

Publications (1)

Publication Number Publication Date
DK2342226T3 true DK2342226T3 (en) 2016-09-26

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DK09816950.1T DK2342226T3 (en) 2008-09-26 2009-09-25 HUMAN ANTI-PD-1, PD-L1 AND PD-L2 ANTIBODIES AND APPLICATIONS THEREOF

Country Status (16)

Country Link
US (5) US8552154B2 (de)
EP (3) EP3133086B1 (de)
JP (4) JP6087503B2 (de)
KR (4) KR101924874B1 (de)
CN (2) CN102264762B (de)
AU (4) AU2009296392B2 (de)
BR (1) BRPI0919377A2 (de)
CA (2) CA2998281C (de)
DK (1) DK2342226T3 (de)
ES (2) ES2592216T3 (de)
HU (1) HUE030807T2 (de)
IL (3) IL211830A (de)
MX (2) MX349463B (de)
PL (1) PL2342226T3 (de)
SI (1) SI2342226T1 (de)
WO (1) WO2010036959A2 (de)

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WO2009114335A2 (en) * 2008-03-12 2009-09-17 Merck & Co., Inc. Pd-1 binding proteins
EP2285960B1 (de) 2008-05-08 2015-07-08 Asuragen, INC. Zusammensetzungen und verfahren in zusammenhang mit der mirna-184modulation von neovaskularisation oder angiogenese
US9650639B2 (en) 2008-05-19 2017-05-16 Advaxis, Inc. Dual delivery system for heterologous antigens
JP5757863B2 (ja) 2008-05-19 2015-08-05 アドバクシス インコーポレイテッド 異種抗原のための二重送達システム
US9017660B2 (en) 2009-11-11 2015-04-28 Advaxis, Inc. Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors
CN102264762B (zh) 2008-09-26 2018-03-27 达纳-法伯癌症研究公司 人抗pd‑1、pd‑l1和pd‑l2的抗体及其应用
US20120058178A1 (en) 2009-03-30 2012-03-08 Eisai R&D Management Co., Ltd. Liposome Composition
US20100329983A1 (en) 2009-06-26 2010-12-30 Soricimed Biopharma Inc. Compounds and methods for the detection of trpv-6 cancers and drug delivery
US10016617B2 (en) 2009-11-11 2018-07-10 The Trustees Of The University Of Pennsylvania Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers
TW201134488A (en) * 2010-03-11 2011-10-16 Ucb Pharma Sa PD-1 antibodies
CA2791930A1 (en) 2010-03-11 2011-09-15 Kerry Louise Tyson Pd-1 antibody
EP2621527A4 (de) 2010-10-01 2015-12-09 Univ Pennsylvania Verwendung von listerien-impfstoffvektoren zur umkehrung einer impfstoff-unempfänglichkeit bei patienten mit parasiteninfektionen
WO2012048113A2 (en) 2010-10-07 2012-04-12 The General Hospital Corporation Biomarkers of cancer
EP3332804A1 (de) 2011-03-11 2018-06-13 Advaxis, Inc. Adjuvanzien auf listerien-basis
WO2012145493A1 (en) * 2011-04-20 2012-10-26 Amplimmune, Inc. Antibodies and other molecules that bind b7-h1 and pd-1
CA2834548C (en) 2011-04-28 2021-06-01 The Broad Institute, Inc. Inhibitors of histone deacetylase
CN102298053B (zh) * 2011-05-20 2014-01-29 中山大学肿瘤防治中心 原发性肝细胞肝癌术后复发风险评估的组合抗体试剂盒
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