NO325273B1 - GLP-1-derivater - Google Patents

GLP-1-derivater Download PDF

Info

Publication number: NO325273B1
Authority: NO; Norway
Prior art keywords: glp; arg26; arg; lys; derivative according
Prior art date: 1996-08-30

Application number

NO19990950A

Other languages

English (en)

Norwegian (no)

Other versions

NO990950D0 (no

NO990950L (no

Inventor

Per Franklin Nielsen

Liselotte Bjerre Knudsen

Per Olaf Huusfeldt

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-30

Filing date

1999-02-26

Publication date

2008-03-17

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27221005&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO325273(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1999-02-26 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1999-02-26 Publication of NO990950D0 publication Critical patent/NO990950D0/no

1999-04-28 Publication of NO990950L publication Critical patent/NO990950L/no

2008-03-17 Publication of NO325273B1 publication Critical patent/NO325273B1/no

Links

DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical class C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 title claims abstract description 348
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Classifications

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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Endocrinology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Obesity (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Zoology (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Emergency Medicine (AREA)
Toxicology (AREA)
Child & Adolescent Psychology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Vehicle Interior And Exterior Ornaments, Soundproofing, And Insulation (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO19990950A 1996-08-30 1999-02-26 GLP-1-derivater NO325273B1 (no)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DK93196		1996-08-30
DK125996		1996-11-08
DK147096		1996-12-20
PCT/DK1997/000340 WO1998008871A1 (en)	1996-08-30	1997-08-22	Glp-1 derivatives

Publications (3)

Publication Number	Publication Date
NO990950D0 NO990950D0 (no)	1999-02-26
NO990950L NO990950L (no)	1999-04-28
NO325273B1 true NO325273B1 (no)	2008-03-17

Family

ID=27221005

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
NO19990950A NO325273B1 (no)	1996-08-30	1999-02-26	GLP-1-derivater
NO2009027C NO2009027I2 (no)	1996-08-30	2009-11-18	Arg34Lys26(N epsilon-(gamma-glutamyl(N alfa-heksadecanoyl))-GLP-1-(7-37)
NO2019036C NO2019036I1 (no)	1996-08-30	2019-09-20	Liraglutid - forlenget SPC

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
NO2009027C NO2009027I2 (no)	1996-08-30	2009-11-18	Arg34Lys26(N epsilon-(gamma-glutamyl(N alfa-heksadecanoyl))-GLP-1-(7-37)
NO2019036C NO2019036I1 (no)	1996-08-30	2019-09-20	Liraglutid - forlenget SPC

Country Status (21)

Country	Link
EP (2)	EP0944648B1 (ru)
JP (3)	JP3149958B2 (ru)
KR (1)	KR100556067B1 (ru)
CN (1)	CN1271086C (ru)
AT (1)	ATE356830T1 (ru)
BR (1)	BRPI9711437B8 (ru)
CA (2)	CA2468374C (ru)
CZ (1)	CZ300837B6 (ru)
DE (3)	DE69737479D1 (ru)
DK (1)	DK0944648T3 (ru)
ES (1)	ES2283025T3 (ru)
FR (1)	FR09C0054I2 (ru)
HU (1)	HU227021B1 (ru)
IL (3)	IL128332A0 (ru)
NL (1)	NL300422I2 (ru)
NO (3)	NO325273B1 (ru)
PL (1)	PL192359B1 (ru)
PT (1)	PT944648E (ru)
RU (1)	RU2214419C2 (ru)
UA (1)	UA72181C2 (ru)
WO (1)	WO1998008871A1 (ru)

Families Citing this family (493)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
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1997
- 1997-08-22 JP JP51118398A patent/JP3149958B2/ja not_active Expired - Lifetime
- 1997-08-22 CN CNB971984131A patent/CN1271086C/zh not_active Expired - Lifetime
- 1997-08-22 PT PT97935509T patent/PT944648E/pt unknown
- 1997-08-22 PL PL331896A patent/PL192359B1/pl unknown
- 1997-08-22 DE DE69737479A patent/DE69737479D1/de not_active Expired - Lifetime
- 1997-08-22 BR BRPI9711437A patent/BRPI9711437B8/pt not_active IP Right Cessation
- 1997-08-22 DE DE122009000079C patent/DE122009000079I2/de active Active
- 1997-08-22 KR KR1019997001750A patent/KR100556067B1/ko active Protection Beyond IP Right Term
- 1997-08-22 WO PCT/DK1997/000340 patent/WO1998008871A1/en active Application Filing
- 1997-08-22 EP EP97935509A patent/EP0944648B1/en not_active Expired - Lifetime
- 1997-08-22 AT AT97935509T patent/ATE356830T1/de active
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- 1997-08-22 DE DE69737479T patent/DE69737479T4/de not_active Expired - Lifetime
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- 1997-08-22 CZ CZ0062999A patent/CZ300837B6/cs not_active IP Right Cessation
- 1997-08-22 RU RU99106518/04A patent/RU2214419C2/ru active Protection Beyond IP Right Term
- 1997-08-22 DK DK97935509T patent/DK0944648T3/da active
- 1997-08-22 UA UA99021142A patent/UA72181C2/ru unknown
- 1997-08-22 IL IL12833297A patent/IL128332A0/xx active IP Right Grant
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- 1997-08-22 HU HU9903714A patent/HU227021B1/hu active Protection Beyond IP Right Term
- 1997-08-22 EP EP07103319A patent/EP1826216A1/en not_active Withdrawn
1999
- 1999-02-02 IL IL128332A patent/IL128332A/en active Protection Beyond IP Right Term
- 1999-02-26 NO NO19990950A patent/NO325273B1/no not_active IP Right Cessation
2000
- 2000-05-19 JP JP2000152778A patent/JP2001011095A/ja active Pending
2006
- 2006-07-24 JP JP2006201324A patent/JP2006348038A/ja active Pending
2008
- 2008-01-30 IL IL189136A patent/IL189136A/en not_active IP Right Cessation
2009
- 2009-10-22 NL NL300422C patent/NL300422I2/nl unknown
- 2009-10-23 FR FR09C0054C patent/FR09C0054I2/fr active Active
- 2009-11-18 NO NO2009027C patent/NO2009027I2/no unknown
2019
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Also Published As

Publication number	Publication date
RU2214419C2 (ru)	2003-10-20
BRPI9711437B8 (pt)	2021-05-25
HU227021B1 (en)	2010-05-28
CA2264243A1 (en)	1998-03-05
KR20000035964A (ko)	2000-06-26
DE122009000079I1 (de)	2010-05-27
UA72181C2 (ru)	2005-02-15
IL128332A0 (en)	2000-01-31
DE122009000079I2 (de)	2011-06-16
NO990950D0 (no)	1999-02-26
ATE356830T1 (de)	2007-04-15
JP2001011095A (ja)	2001-01-16
ES2283025T3 (es)	2007-10-16
BRPI9711437B1 (pt)	2017-05-16
EP0944648B1 (en)	2007-03-14
CA2468374C (en)	2010-12-21
PL331896A1 (en)	1999-08-16
KR100556067B1 (ko)	2006-03-07
AU732957C (en)	1998-03-19
AU732957B2 (en)	2001-05-03
HUP9903714A3 (en)	2000-07-28
DK0944648T3 (da)	2007-07-02
PT944648E (pt)	2007-06-26
BR9711437A (pt)	2000-01-18
CZ300837B6 (cs)	2009-08-26
DE69737479T4 (de)	2010-05-06
IL189136A0 (en)	2008-06-05
AU3847897A (en)	1998-03-19
JP2000500505A (ja)	2000-01-18
NL300422I2 (nl)	2010-04-01
NO2009027I1 (no)	2009-11-30
PL192359B1 (pl)	2006-10-31
DE69737479T2 (de)	2007-11-29
CN1271086C (zh)	2006-08-23
CA2264243C (en)	2004-10-05
NO2009027I2 (no)	2015-01-19
HUP9903714A2 (hu)	2000-03-28
NL300422I1 (nl)	2010-01-04
IL189136A (en)	2015-05-31
IL128332A (en)	2008-04-13
EP0944648A1 (en)	1999-09-29
DE69737479D1 (de)	2007-04-26
CZ62999A3 (cs)	1999-07-14
NO2019036I1 (no)	2019-09-20
CA2468374A1 (en)	1998-03-05
CN1232470A (zh)	1999-10-20
NO990950L (no)	1999-04-28
FR09C0054I1 (ru)	2009-04-12
JP3149958B2 (ja)	2001-03-26
JP2006348038A (ja)	2006-12-28
EP1826216A1 (en)	2007-08-29
FR09C0054I2 (fr)	2011-04-01
WO1998008871A1 (en)	1998-03-05

Publication	Publication Date	Title
NO325273B1 (no)	2008-03-17	GLP-1-derivater
EP1056775B1 (en)	2010-04-28	Glp-1 derivatives of glp-1 and exendin with protracted profile of action
EP1060191B1 (en)	2010-04-28	Derivatives of glp-1 analogs
EP1061946B1 (en)	2004-04-28	Glp-1 derivatives with helix-content exceeding 25 %, forming partially structured micellar-like aggregates
US6268343B1 (en)	2001-07-31	Derivatives of GLP-1 analogs
US6458924B2 (en)	2002-10-01	Derivatives of GLP-1 analogs
US8097698B2 (en)	2012-01-17	Derivatives of GLP-1 analogs
CN1951965B (zh)	2011-07-20	Glp-1衍生物
AU3847897C1 (en)	2018-08-02	GLP-1 derivatives
EP1840134B1 (en)	2016-04-13	GLP-1 derivatives
MXPA99001823A (en)	1999-09-01	Glp-1 derivatives

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