SI1605897T1 - Polietilen glikol povezane GLP spojine - Google Patents
Polietilen glikol povezane GLP spojineInfo
- Publication number
- SI1605897T1 SI1605897T1 SI200431937T SI200431937T SI1605897T1 SI 1605897 T1 SI1605897 T1 SI 1605897T1 SI 200431937 T SI200431937 T SI 200431937T SI 200431937 T SI200431937 T SI 200431937T SI 1605897 T1 SI1605897 T1 SI 1605897T1
- Authority
- SI
- Slovenia
- Prior art keywords
- compounds
- polyethelene glycol
- glp
- glycol link
- link glp
- Prior art date
Links
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 title 2
- 101100337060 Caenorhabditis elegans glp-1 gene Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Nutrition Science (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45608103P | 2003-03-19 | 2003-03-19 | |
| PCT/US2004/006082 WO2004093823A2 (en) | 2003-03-19 | 2004-03-19 | Polyethelene glycol link glp-1 compounds |
| EP04722142A EP1605897B1 (en) | 2003-03-19 | 2004-03-19 | Polyethelene glycol link glp-1 compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1605897T1 true SI1605897T1 (sl) | 2012-11-30 |
Family
ID=33310655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200431937T SI1605897T1 (sl) | 2003-03-19 | 2004-03-19 | Polietilen glikol povezane GLP spojine |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7557183B2 (sl) |
| EP (1) | EP1605897B1 (sl) |
| JP (1) | JP2006520818A (sl) |
| KR (1) | KR100733940B1 (sl) |
| CN (1) | CN1832959A (sl) |
| AU (1) | AU2004231461B2 (sl) |
| BR (1) | BRPI0407936A (sl) |
| CA (1) | CA2518336A1 (sl) |
| CO (1) | CO5611157A2 (sl) |
| CR (1) | CR7997A (sl) |
| CY (1) | CY1114035T1 (sl) |
| DK (1) | DK1605897T3 (sl) |
| EA (1) | EA009366B1 (sl) |
| EC (1) | ECSP056025A (sl) |
| ES (1) | ES2390270T3 (sl) |
| HR (1) | HRP20050683A2 (sl) |
| MX (1) | MXPA05009940A (sl) |
| NO (1) | NO20054310L (sl) |
| NZ (1) | NZ541534A (sl) |
| PL (1) | PL1605897T3 (sl) |
| PT (1) | PT1605897E (sl) |
| SI (1) | SI1605897T1 (sl) |
| UA (1) | UA92451C2 (sl) |
| WO (1) | WO2004093823A2 (sl) |
| ZA (1) | ZA200506881B (sl) |
Families Citing this family (118)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| US7157277B2 (en) | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
| US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
| PL1615945T3 (pl) | 2003-04-09 | 2012-03-30 | Ratiopharm Gmbh | Sposoby glikopegylacji i białka/peptydy wytwarzane tymi sposobami |
| US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
| US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
| US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
| US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
| KR20060135661A (ko) | 2003-12-18 | 2006-12-29 | 노보 노르디스크 에이/에스 | 신규 ｇｌｐ-1 화합물 |
| WO2006010143A2 (en) | 2004-07-13 | 2006-01-26 | Neose Technologies, Inc. | Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1] |
| EP2586456B1 (en) | 2004-10-29 | 2016-01-20 | ratiopharm GmbH | Remodeling and glycopegylation of fibroblast growth factor (FGF) |
| AU2006203792B2 (en) | 2005-01-10 | 2011-11-03 | Ratiopharm Gmbh | Glycopegylated Granulocyte Colony Stimulating Factor |
| TWI376234B (en) | 2005-02-01 | 2012-11-11 | Msd Oss Bv | Conjugates of a polypeptide and an oligosaccharide |
| TWI362392B (en) | 2005-03-18 | 2012-04-21 | Novo Nordisk As | Acylated glp-1 compounds |
| MX2007011307A (es) | 2005-03-18 | 2007-10-08 | Novo Nordisk As | Compuestos de glp-1 extendidos. |
| WO2006121569A2 (en) | 2005-04-08 | 2006-11-16 | Neose Technologies, Inc. | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
| JP2008539735A (ja) * | 2005-05-06 | 2008-11-20 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | グルカゴン様ペプチド１（ｇｌｐ−１）受容体アンタゴニストおよびそれらの薬理学的使用方法 |
| PL1881850T3 (pl) * | 2005-05-13 | 2011-03-31 | Lilly Co Eli | Pegylowane związki GLP-1 |
| JP5216580B2 (ja) | 2005-05-25 | 2013-06-19 | ノヴォ ノルディスク アー／エス | グリコペグ化第ｉｘ因子 |
| US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
| CN101296708B (zh) * | 2005-10-26 | 2011-12-07 | 伊莱利利公司 | 选择性vpac2受体肽激动剂 |
| US20090048440A1 (en) | 2005-11-03 | 2009-02-19 | Neose Technologies, Inc. | Nucleotide Sugar Purification Using Membranes |
| CN101534846B (zh) | 2005-11-07 | 2014-11-05 | 印第安纳大学研究及科技有限公司 | 显示生理学溶解性和稳定性的胰高血糖素类似物 |
| WO2007075534A2 (en) * | 2005-12-16 | 2007-07-05 | Nektar Therapeutics Al, Corporation | Polymer conjugates of glp-1 |
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| CN102827284B (zh) | 2006-11-14 | 2015-07-29 | 上海仁会生物制药股份有限公司 | 带有聚乙二醇基团的Exendin或其类似物及其制剂和用途 |
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| AU2009219232B2 (en) | 2008-02-27 | 2014-02-27 | Novo Nordisk A/S | Conjugated Factor VIII molecules |
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| CA2727161A1 (en) * | 2008-06-17 | 2009-12-23 | Indiana University Research And Technology Corporation | Glucagon analogs exhibiting enhanced solubility and stability physiological ph buffers |
| IT1392655B1 (it) * | 2008-11-20 | 2012-03-16 | Bio Ker S R L | Site-specific monoconjugated insulinotropic glp-1 peptides. |
| AU2009335712B2 (en) | 2008-12-19 | 2015-09-17 | Indiana University Research And Technology Corporation | Insulin analogs |
| MX2011006524A (es) | 2008-12-19 | 2011-08-17 | Univ Indiana Res & Tech Corp | Profarmacos de peptido de la superfamilia de glucagon basado en amida. |
| CA2747195A1 (en) * | 2008-12-19 | 2010-07-15 | Indiana University Research And Technology Corporation | Dipeptide linked medicinal agents |
| CN102245624B (zh) | 2008-12-19 | 2016-08-10 | 印第安纳大学研究及科技有限公司 | 基于酰胺的胰岛素前药 |
| CA2755395C (en) | 2009-03-20 | 2015-02-24 | Hanmi Holdings Co., Ltd. | Method for preparing a site-specific physiologically active polypeptide conjugate |
| CN101870728A (zh) | 2009-04-23 | 2010-10-27 | 派格生物医药(苏州)有限公司 | 新型Exendin变体及其缀合物 |
| EP2443146B1 (en) | 2009-06-16 | 2016-10-05 | Indiana University Research And Technology Corporation | Gip receptor-active glucagon compounds |
| BR112012011467A2 (pt) | 2009-10-30 | 2019-09-24 | Otsuka Chemical Co Ltd | forma glicosilada de análogo ao glp-1 antigênico. |
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| EP2512503A4 (en) | 2009-12-18 | 2013-08-21 | Univ Indiana Res & Tech Corp | COAGONISTS OF GLUCAGON / GLP-1 RECEPTOR |
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| ES2661228T3 (es) | 2010-05-13 | 2018-03-28 | Indiana University Research And Technology Corporation | Péptidos de la superfamilia de glucagón que muestran actividad de receptor nuclear de hormona |
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| ES2713952T3 (es) | 2010-12-22 | 2019-05-24 | Univ Indiana Res & Tech Corp | Análogos de glucagón que muestran actividad de receptor de GIP |
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| HRP20170890T1 (hr) | 2011-06-22 | 2017-09-08 | Indiana University Research And Technology Corporation | Suagonisti glukagonskog/glp-1 receptora |
| CN102321170B (zh) * | 2011-09-14 | 2013-11-13 | 深圳翰宇药业股份有限公司 | 利拉鲁肽变构体及其缀合物 |
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| EP2793932B1 (en) | 2011-12-20 | 2018-10-03 | Indiana University Research and Technology Corporation | Ctp-based insulin analogs for treatment of diabetes |
| ES2715308T3 (es) | 2012-03-22 | 2019-06-03 | Novo Nordisk As | Composiciones que comprenden un agente de suministro y su preparación |
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2004
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- 2004-03-19 AU AU2004231461A patent/AU2004231461B2/en not_active Ceased
- 2004-03-19 PT PT04722142T patent/PT1605897E/pt unknown
- 2004-03-19 HR HR20050683A patent/HRP20050683A2/xx not_active Application Discontinuation
- 2004-03-19 WO PCT/US2004/006082 patent/WO2004093823A2/en active Application Filing
- 2004-03-19 US US10/548,328 patent/US7557183B2/en not_active Expired - Fee Related
- 2004-03-19 PL PL04722142T patent/PL1605897T3/pl unknown
- 2004-03-19 EA EA200501482A patent/EA009366B1/ru not_active IP Right Cessation
- 2004-03-19 MX MXPA05009940A patent/MXPA05009940A/es active IP Right Grant
- 2004-03-19 SI SI200431937T patent/SI1605897T1/sl unknown
- 2004-03-19 NZ NZ541534A patent/NZ541534A/en not_active IP Right Cessation
- 2004-03-19 EP EP04722142A patent/EP1605897B1/en not_active Expired - Lifetime
- 2004-03-19 BR BRPI0407936-1A patent/BRPI0407936A/pt not_active IP Right Cessation
- 2004-03-19 UA UAA200508688A patent/UA92451C2/ru unknown
- 2004-03-19 CA CA002518336A patent/CA2518336A1/en not_active Abandoned
- 2004-03-19 ES ES04722142T patent/ES2390270T3/es not_active Expired - Lifetime
- 2004-03-19 JP JP2006508916A patent/JP2006520818A/ja active Pending
- 2004-03-19 CN CNA2004800074368A patent/CN1832959A/zh active Pending
- 2004-03-19 DK DK04722142.9T patent/DK1605897T3/da active
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- 2005-09-19 EC EC2005006025A patent/ECSP056025A/es unknown
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- 2005-09-19 NO NO20054310A patent/NO20054310L/no not_active Application Discontinuation
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| ES2390270T3 (es) | 2012-11-08 |
| EP1605897B1 (en) | 2012-07-25 |
| NO20054310D0 (no) | 2005-09-19 |
| HRP20050683A2 (en) | 2006-07-31 |
| CN1832959A (zh) | 2006-09-13 |
| DK1605897T3 (da) | 2012-08-20 |
| UA92451C2 (en) | 2010-11-10 |
| NO20054310L (no) | 2005-11-16 |
| NZ541534A (en) | 2008-05-30 |
| PT1605897E (pt) | 2012-09-10 |
| US20080113905A1 (en) | 2008-05-15 |
| EP1605897A4 (en) | 2010-08-04 |
| WO2004093823A3 (en) | 2005-12-22 |
| EA009366B1 (ru) | 2007-12-28 |
| JP2006520818A (ja) | 2006-09-14 |
| MXPA05009940A (es) | 2005-12-05 |
| WO2004093823A2 (en) | 2004-11-04 |
| ECSP056025A (es) | 2006-01-27 |
| PL1605897T3 (pl) | 2012-12-31 |
| EA200501482A1 (ru) | 2006-06-30 |
| KR100733940B1 (ko) | 2007-06-29 |
| AU2004231461B2 (en) | 2009-11-12 |
| EP1605897A2 (en) | 2005-12-21 |
| AU2004231461A1 (en) | 2004-11-04 |
| CY1114035T1 (el) | 2016-07-27 |
| CO5611157A2 (es) | 2006-02-28 |
| KR20050111386A (ko) | 2005-11-24 |
| ZA200506881B (en) | 2006-11-29 |
| CA2518336A1 (en) | 2004-11-04 |
| CR7997A (es) | 2008-11-28 |
| BRPI0407936A (pt) | 2006-02-21 |
| US7557183B2 (en) | 2009-07-07 |
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