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ES2782119T3 - Antígenos de F de prefusión del VRS - Google Patents

Antígenos de F de prefusión del VRS Download PDF

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Publication number
ES2782119T3
ES2782119T3 ES17191721T ES17191721T ES2782119T3 ES 2782119 T3 ES2782119 T3 ES 2782119T3 ES 17191721 T ES17191721 T ES 17191721T ES 17191721 T ES17191721 T ES 17191721T ES 2782119 T3 ES2782119 T3 ES 2782119T3
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ES
Spain
Prior art keywords
rsv
cysteine residue
region
protein
hra
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ES17191721T
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English (en)
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Kurt Swanson
Andrea Carfi
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GlaxoSmithKline Biologicals SA
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GlaxoSmithKline Biologicals SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Un polipéptido F de prefusión del virus respiratorio sincitial (VRS), en el que la región HRA, restos 137-239 de la SEQ ID NO:1 de la proteína F del VRS de referencia, contiene un resto de cisteína introducido y la región DIII, restos 51-98 y 206-308 de la SEQ ID NO:1 de la proteína F del VRS de referencia, contiene un resto de cisteína introducido, y se forma un puente disulfuro entre el resto de cisteína introducido en le región HRA y el resto de cisteína introducido en la región DIII que impide la formación del paquete de seis hélice HRA-HRB postfusión y estabiliza el polipéptido F de prefusión de RSV que comprende además un dominio de trimerización heterólogo, que es la espiral enrrollada de la proteína de cremallera de leucina de la levadura GCN4, la secuencia de timerización de la fibritina T4 del bacteriófago ("foldon") o el dominio de trimerización de la HA de la influenza.
ES17191721T 2011-05-13 2012-05-14 Antígenos de F de prefusión del VRS Active ES2782119T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161486005P 2011-05-13 2011-05-13

Publications (1)

Publication Number Publication Date
ES2782119T3 true ES2782119T3 (es) 2020-09-10

Family

ID=46124783

Family Applications (2)

Application Number Title Priority Date Filing Date
ES17191721T Active ES2782119T3 (es) 2011-05-13 2012-05-14 Antígenos de F de prefusión del VRS
ES12722057.2T Active ES2651143T3 (es) 2011-05-13 2012-05-14 Antígenos de F de prefusión del VRS

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES12722057.2T Active ES2651143T3 (es) 2011-05-13 2012-05-14 Antígenos de F de prefusión del VRS

Country Status (24)

Country Link
US (8) US20140248314A1 (es)
EP (2) EP3275892B1 (es)
JP (1) JP2014519819A (es)
CN (1) CN103842374A (es)
AU (1) AU2012255971A1 (es)
BR (1) BR112013029169B1 (es)
CA (1) CA2835644C (es)
CY (2) CY1119849T1 (es)
DK (2) DK2707385T3 (es)
ES (2) ES2782119T3 (es)
FR (1) FR23C1046I2 (es)
HR (2) HRP20171703T1 (es)
HU (2) HUE048777T2 (es)
LT (2) LT2707385T (es)
MX (1) MX351011B (es)
NO (1) NO2707385T3 (es)
PL (2) PL3275892T3 (es)
PT (2) PT3275892T (es)
RS (1) RS56748B1 (es)
RU (1) RU2013155485A (es)
SG (1) SG194755A1 (es)
SI (2) SI3275892T1 (es)
SM (1) SMT201700569T1 (es)
WO (1) WO2012158613A1 (es)

Families Citing this family (108)

* Cited by examiner, † Cited by third party
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