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HRP20171703T1 - Predfuzijski antigeni rsv f - Google Patents

Predfuzijski antigeni rsv f Download PDF

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Publication number
HRP20171703T1
HRP20171703T1 HRP20171703TT HRP20171703T HRP20171703T1 HR P20171703 T1 HRP20171703 T1 HR P20171703T1 HR P20171703T T HRP20171703T T HR P20171703TT HR P20171703 T HRP20171703 T HR P20171703T HR P20171703 T1 HRP20171703 T1 HR P20171703T1
Authority
HR
Croatia
Prior art keywords
rsv
fusion polypeptide
polypeptide according
fusion
cysteine residue
Prior art date
Application number
HRP20171703TT
Other languages
English (en)
Inventor
Kurt Swanson
Andrea Carfi
Original Assignee
Glaxosmithkline Biologicals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46124783&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20171703(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Biologicals Sa filed Critical Glaxosmithkline Biologicals Sa
Publication of HRP20171703T1 publication Critical patent/HRP20171703T1/hr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (12)

1. Predfuzijski polipeptid F iz respiratornog sincicijskog virusa (RSV), naznačen time što područje HRA, ostaci 137-239 iz referentnog proteina RSV F sa SEQ ID NO:1, sadrži ubačeni cisteinski ostatak, te što područje DIII, ostaci 51-98 i 206-308 iz referentnog proteina RSV F sa SEQ ID NO:1, sadrži ubačeni cisteinski ostatak, gdje se formira disulfidna veza između ubačenog cisteinskog ostatka u području HRA i ubačenog cisteinskog ostatka u području DIII, koja stabilizira predfuzijski polipeptid RSV F.
2. Predfuzijski polipeptid RSV F u skladu s patentnim zahtjevom 1, naznačen time što su navedene cisteinske mutacije međusobno udaljene otprilike 10 Å.
3. Predfuzijski polipeptid RSV F u skladu s bilo kojim od patentnim zahtjevom 1 ili 2, naznačen time što je predfuzijski polipeptid RSV F topljiva ektodomena RSV F.
4. Predfuzijski polipeptid RSV F u skladu s bilo kojim od patentnih zahtjeva 1 do 3, naznačen time što dodatno sadrži heterolognu oligomerizacijsku domenu, epitop ili signalni peptid.
5. Predfuzijski polipeptid RSV F u skladu s patentnim zahtjevom 4, naznačen time što je navedena heterologna oligomerizacijska domena trimerizacijska domena.
6. Predfuzijski polipeptid RSV F u skladu s patentnim zahtjevom 5, naznačen time što se trimerizacijsku domenu bira između hemaglutinina iz virusa influence, SARS šiljka, HIV gp41, NadA, modificiranog GCN4, GCN4 ili ATCaze.
7. Imunogeni pripravak, naznačen time što sadrži predfuzijski polipeptid RSV F u skladu s bilo kojim od patentnih zahtjeva 1 do 6 i, izborno, adjuvans.
8. Imunogeni pripravak u skladu s patentnim zahtjevom 7, naznačen time što se adjuvans bira iz skupine koju čine: aluminijeva sol, emulzija skvalena u vodi, benzonaftiridinski spoj, fosfolipidni spoj, niskomolekulski imunopotencijator i kombinacije bilo kojeg od gore navedenog.
9. Izolirana nukleinska kiselina, naznačena time što kodira predfuzijski polipeptid RSV F u skladu s bilo kojim od patentnih zahtjeva 1 do 6.
10. Izolirana nukleinska kiselina u skladu s patentnim zahtjevom 9, naznačena time što je samoreplicirajuća molekula RNA.
11. Imunogeni pripravak, naznačen time što sadrži samoreplicirajuću molekulu RNA u skladu s patentnim zahtjevom 10 i, izborno, sustav za unos RNA.
12. Imunogeni pripravak u skladu s patentnim zahtjevom 7, 8 ili 11, naznačen time što je namijenjen upotrebi kao medikament.
HRP20171703TT 2011-05-13 2012-05-14 Predfuzijski antigeni rsv f HRP20171703T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161486005P 2011-05-13 2011-05-13
EP12722057.2A EP2707385B1 (en) 2011-05-13 2012-05-14 Pre-fusion rsv f antigens
PCT/US2012/037773 WO2012158613A1 (en) 2011-05-13 2012-05-14 Pre-fusion rsv f antigens

Publications (1)

Publication Number Publication Date
HRP20171703T1 true HRP20171703T1 (hr) 2017-12-15

Family

ID=46124783

Family Applications (2)

Application Number Title Priority Date Filing Date
HRP20171703TT HRP20171703T1 (hr) 2011-05-13 2012-05-14 Predfuzijski antigeni rsv f
HRP20200451TT HRP20200451T1 (hr) 2011-05-13 2020-03-18 Predfuzijski antigeni f iz rsv

Family Applications After (1)

Application Number Title Priority Date Filing Date
HRP20200451TT HRP20200451T1 (hr) 2011-05-13 2020-03-18 Predfuzijski antigeni f iz rsv

Country Status (24)

Country Link
US (8) US20140248314A1 (hr)
EP (2) EP3275892B1 (hr)
JP (1) JP2014519819A (hr)
CN (1) CN103842374A (hr)
AU (1) AU2012255971A1 (hr)
BR (1) BR112013029169B1 (hr)
CA (1) CA2835644C (hr)
CY (2) CY1119849T1 (hr)
DK (2) DK2707385T3 (hr)
ES (2) ES2782119T3 (hr)
FR (1) FR23C1046I2 (hr)
HR (2) HRP20171703T1 (hr)
HU (2) HUE048777T2 (hr)
LT (2) LT2707385T (hr)
MX (1) MX351011B (hr)
NO (1) NO2707385T3 (hr)
PL (2) PL2707385T3 (hr)
PT (2) PT3275892T (hr)
RS (1) RS56748B1 (hr)
RU (1) RU2013155485A (hr)
SG (1) SG194755A1 (hr)
SI (2) SI3275892T1 (hr)
SM (1) SMT201700569T1 (hr)
WO (1) WO2012158613A1 (hr)

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