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CY1118777T1 - Μεθοδος για την παρασκευη ενωσεων χρησιμων ως αναστολεις του sglt2 - Google Patents

Μεθοδος για την παρασκευη ενωσεων χρησιμων ως αναστολεις του sglt2

Info

Publication number
CY1118777T1
CY1118777T1 CY20171100390T CY171100390T CY1118777T1 CY 1118777 T1 CY1118777 T1 CY 1118777T1 CY 20171100390 T CY20171100390 T CY 20171100390T CY 171100390 T CY171100390 T CY 171100390T CY 1118777 T1 CY1118777 T1 CY 1118777T1
Authority
CY
Cyprus
Prior art keywords
formula
compound
sglt2
union
suspensions
Prior art date
Application number
CY20171100390T
Other languages
English (en)
Inventor
Vittorio Farina
Sebastien François Emmanuel Lemaire
Ioannis N Houpis
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43127364&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1118777(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CY1118777T1 publication Critical patent/CY1118777T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/06—Zinc compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Η παρούσα εφεύρεση κατευθύνεται σε μία νέα μέθοδο για την παρασκευή ενώσεων του τύπου (I): ή φαρμακευτικώς αποδεκτού άλατος ή διαλυτώματος αυτών, που περιλαμβάνει: τύπο (VII) (VIII) (IX) αντίδραση μιας ένωσης του τύπου (VII), όπου Μ2 είναι είδος ψευδαργύρου, με μία ένωση του τύπου (VIII), όπου εκάστη Ζ είναι μία ανεξαρτήτως επιλεγόμενη ομάδα προστασίας οξυγόνου και όπου LG2 είναι μία αποχωρούσα ομάδα· σε ένα μίγμα διαλύτη αιθέρα και διαλύτη υδρογονάνθρακα· για να αποδοθεί η αντίστοιχη ένωση του τύπου (IX)· απο-προστασία της ένωσης του τύπου (IX)· για να αποδοθεί η αντίστοιχη ένωση του τύπου (I).
CY20171100390T 2009-10-14 2017-03-31 Μεθοδος για την παρασκευη ενωσεων χρησιμων ως αναστολεις του sglt2 CY1118777T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25137809P 2009-10-14 2009-10-14
PCT/US2010/052598 WO2011047113A1 (en) 2009-10-14 2010-10-14 Process for the preparation of compounds useful as inhibitors of sglt2

Publications (1)

Publication Number Publication Date
CY1118777T1 true CY1118777T1 (el) 2017-07-12

Family

ID=43127364

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20171100390T CY1118777T1 (el) 2009-10-14 2017-03-31 Μεθοδος για την παρασκευη ενωσεων χρησιμων ως αναστολεις του sglt2

Country Status (30)

Country Link
US (1) US9174971B2 (el)
EP (1) EP2488515B1 (el)
JP (1) JP5833011B2 (el)
KR (1) KR101730920B1 (el)
CN (1) CN102648196B (el)
AU (1) AU2010306797B2 (el)
BR (1) BR112012008939B1 (el)
CA (1) CA2777528C (el)
CL (1) CL2012000929A1 (el)
CY (1) CY1118777T1 (el)
DK (1) DK2488515T3 (el)
EA (1) EA024368B1 (el)
ES (1) ES2620469T3 (el)
HR (1) HRP20170446T1 (el)
HU (1) HUE031375T2 (el)
IL (1) IL219094A (el)
IN (1) IN2012DN03299A (el)
LT (1) LT2488515T (el)
ME (1) ME02634B (el)
MX (1) MX340214B (el)
NZ (1) NZ599306A (el)
PH (1) PH12012500698A1 (el)
PL (1) PL2488515T3 (el)
PT (1) PT2488515T (el)
RS (1) RS55909B1 (el)
SG (1) SG10201500258WA (el)
SI (1) SI2488515T1 (el)
SM (1) SMT201700162T1 (el)
UA (1) UA109883C2 (el)
WO (1) WO2011047113A1 (el)

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US9056850B2 (en) * 2008-10-17 2015-06-16 Janssen Pharmaceutica N.V. Process for the preparation of compounds useful as inhibitors of SGLT
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CN105008379B (zh) * 2013-02-26 2018-06-29 田边三菱制药株式会社 α-卤代四酰基葡萄糖的制造方法
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CN103980261B (zh) * 2014-04-01 2016-06-29 天津大学 卡格列净的a晶型及其结晶制备方法
CN103980262B (zh) * 2014-04-01 2016-06-22 天津大学 卡格列净的b晶型及其结晶制备方法
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CN103936726B (zh) * 2014-04-18 2016-06-15 王军 晶体、制备方法及其用途
CN105330706B (zh) * 2014-06-05 2019-04-16 江苏豪森药业集团有限公司 卡格列净中间体的制备方法
US20170247359A1 (en) * 2014-09-05 2017-08-31 Mylan Laboratories Ltd. Process for the preparation of canagliflozin
CN104402946B (zh) * 2014-11-17 2018-01-02 连云港恒运药业有限公司 卡格列净中间体及其无定形的制备方法
CN104530023A (zh) * 2014-12-25 2015-04-22 重庆医药工业研究院有限责任公司 一种卡格列净晶型i及其制备方法
CN104557895B (zh) * 2015-01-27 2017-10-31 江苏嘉逸医药有限公司 1‑(β‑D‑吡喃葡糖基)‑4‑甲基‑3‑[5‑(4‑氟苯基)‑2‑噻吩基甲基]苯的合成工艺
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