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CY1113184T1 - Μεθοδος για την παρασκευη θεραπευτικως πολυτιμων παραγωγων τριφαινυλβουτενιου - Google Patents

Μεθοδος για την παρασκευη θεραπευτικως πολυτιμων παραγωγων τριφαινυλβουτενιου

Info

Publication number
CY1113184T1
CY1113184T1 CY20121100670T CY121100670T CY1113184T1 CY 1113184 T1 CY1113184 T1 CY 1113184T1 CY 20121100670 T CY20121100670 T CY 20121100670T CY 121100670 T CY121100670 T CY 121100670T CY 1113184 T1 CY1113184 T1 CY 1113184T1
Authority
CY
Cyprus
Prior art keywords
preparation
therapeutically
trifinylbutenium
producers
differential
Prior art date
Application number
CY20121100670T
Other languages
English (en)
Inventor
Marja Södervall
Maire Eloranta
Arja Kalapudas
Original Assignee
Hormos Medical Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hormos Medical Ltd. filed Critical Hormos Medical Ltd.
Publication of CY1113184T1 publication Critical patent/CY1113184T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/30—Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Η παρούσα εφεύρεση αφορά μέθοδο για την παρασκευή θεραπευτικώς πολύτιμων παραγώγων τριφαινυλβουτενίου, ειδικώς ospemifene ή fispemifene, τύπου (Ι).
CY20121100670T 2007-02-14 2012-07-26 Μεθοδος για την παρασκευη θεραπευτικως πολυτιμων παραγωγων τριφαινυλβουτενιου CY1113184T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88983807P 2007-02-14 2007-02-14
EP08718510A EP2121553B1 (en) 2007-02-14 2008-02-13 Method for the preparation of therapeutically valuable triphenylbutene derivatives

Publications (1)

Publication Number Publication Date
CY1113184T1 true CY1113184T1 (el) 2016-04-13

Family

ID=39271403

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100670T CY1113184T1 (el) 2007-02-14 2012-07-26 Μεθοδος για την παρασκευη θεραπευτικως πολυτιμων παραγωγων τριφαινυλβουτενιου

Country Status (19)

Country Link
US (2) US7812197B2 (el)
EP (3) EP2518039B8 (el)
JP (1) JP5363344B2 (el)
KR (1) KR101510646B1 (el)
CN (1) CN101636372B (el)
AU (1) AU2008214530B2 (el)
BR (2) BRPI0807675B1 (el)
CA (1) CA2677861C (el)
CY (1) CY1113184T1 (el)
DK (1) DK2121553T3 (el)
ES (3) ES2590262T3 (el)
HK (2) HK1139379A1 (el)
HR (1) HRP20141107T1 (el)
MX (1) MX2009008660A (el)
PL (1) PL2121553T3 (el)
PT (1) PT2121553E (el)
RU (1) RU2465261C2 (el)
SI (2) SI2518039T1 (el)
WO (1) WO2008099059A1 (el)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008099059A1 (en) * 2007-02-14 2008-08-21 Hormos Medical Ltd Method for the preparation of therapeutically valuable triphenylbutene derivatives
PT2526080E (pt) * 2010-01-19 2014-05-06 Cambrex Karlskoga Ab Novos processos para produção de derivados de benzofenona
KR101308258B1 (ko) * 2010-10-15 2013-09-13 씨제이제일제당 (주) 엔독시펜의 신규한 제조 방법
JP6174156B2 (ja) * 2012-10-19 2017-08-02 フェルミオン オサケ ユキチュア オスペミフェンの製造方法
EP2909163A1 (en) * 2012-10-19 2015-08-26 Fermion Oy A process for the preparation of ospemifene
CN103739456A (zh) * 2013-12-03 2014-04-23 镇江圣安医药有限公司 2-（对-（（z-4-氯-1,2-二苯基-1-丁烯基）苯氧基）乙醇的新型衍生物及其应用
CN104788300B (zh) * 2014-01-22 2017-01-11 南京华威医药科技开发有限公司 欧司哌米芬多晶型
CN104230723B (zh) * 2014-08-21 2016-08-24 凯莱英医药集团（天津）股份有限公司 托瑞米芬的合成方法
EP3181545B1 (en) * 2014-09-16 2023-11-01 Shionogi & Co., Ltd. Process for the preparation of ospemifene
ES2717546T3 (es) 2014-12-29 2019-06-21 Olon Spa Proceso para la preparación de ospemifeno y fispemifeno
WO2016110805A1 (en) * 2015-01-09 2016-07-14 Glenmark Pharmaceuticals Limited Process for preparation of ospemifene
WO2017159669A1 (ja) * 2016-03-15 2017-09-21 塩野義製薬株式会社 フェノキシエタノール誘導体の製造方法
KR20240041745A (ko) 2022-09-23 2024-04-01 김민정 입체음향 베개

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2641075C2 (de) * 1975-09-29 1985-11-14 The Regents Of The University Of California, Berkeley, Calif. Verfahren zur Herstellung von symmetrischen Olefinen
JPS5422313A (en) 1977-07-22 1979-02-20 Kougai Boushi Chiyousa Kenkiyu Process for preparing nnformylamine
US4656187A (en) 1981-08-03 1987-04-07 Eli Lilly And Company Treatment of mammary cancer
FI77839C (fi) 1982-05-27 1989-05-10 Farmos Oy Foerfarande foer framstaellning av nya terapeutiskt effektiva trifenylalkan- och alkenderivat.
GB2126576B (en) * 1982-06-25 1985-06-19 Farmos Group Limited Alkane and alkene derivatives
US5491173A (en) 1982-06-25 1996-02-13 Orion-Yhtyma Oy Tri-phenyl alkene derivatives and their preparation and use
US4729999A (en) 1984-10-12 1988-03-08 Bcm Technologies Antiestrogen therapy for symptoms of estrogen deficiency
US4935243A (en) 1988-12-19 1990-06-19 Pharmacaps, Inc. Chewable, edible soft gelatin capsule
US5189212A (en) 1990-09-07 1993-02-23 University Of Georgia Research Foundation, Inc. Triarylethylene carboxylic acids with estrogenic activity
US5219548A (en) 1990-10-01 1993-06-15 Board Of Regents, The University Of Texas System High affinity halogenated-tamoxifen derivatives and uses thereof
EP0551434B1 (en) 1990-10-01 1995-11-15 The Board Of Regents, The University Of Texas System High affinity tamoxifen derivatives and uses thereof
US6096874A (en) 1990-10-01 2000-08-01 Board Of Regents, The University Of Texas System High affinity tamoxifen derivatives
US5118667A (en) 1991-05-03 1992-06-02 Celtrix Pharmaceuticals, Inc. Bone growth factors and inhibitors of bone resorption for promoting bone formation
US5196435A (en) 1991-11-21 1993-03-23 Eli Lilly And Company Melatonin derivatives and combinations with antiestrogen compounds for treating mammalian breast carcinoma
GB9207437D0 (en) 1992-04-03 1992-05-20 Orion Yhtymae Oy Topical administration of toremifene and its metabolites
US5352699A (en) 1992-04-30 1994-10-04 University Of Massachusetts Medical Center Use of retinioc acid to treat vaginal atrophy
US5446203A (en) 1992-08-25 1995-08-29 New York University Synthesis of haloenones and aryl or alkyl substituted enones or alkenes
DE4335876A1 (de) 1993-10-17 1995-04-20 Schering Ag Kombination von Progesteronantagonisten und Antiöstrogenen mit partialer agonistischer Wirkung für die Hormonsubstitutions-Therapie für peri- und postmenopausale Frauen
US5461064A (en) 1993-12-21 1995-10-24 Eli Lilly And Company Methods of inhibiting atrophy of the skin and vagina
US5650425A (en) 1994-04-04 1997-07-22 Pharmos Corporation Permanently ionic derivatives of steroid hormones and their antagonists
US5681835A (en) 1994-04-25 1997-10-28 Glaxo Wellcome Inc. Non-steroidal ligands for the estrogen receptor
US5604248A (en) 1994-05-05 1997-02-18 Eli Lilly And Company Method for minimizing the uterotrophic effect of tamoxifen and tamoxifen analogs
US5470883A (en) 1994-05-23 1995-11-28 Stromberg; Brent V. Method of treating peripheral vasoconstriction with tamoxifen citrate
FI100692B (fi) 1994-05-24 1998-02-13 Leiras Oy Menetelmä farmaseuttisten koostumusten valmistamiseksi, jolloin koostu mukset pohjautuvat mikroemulsiogeeleihin sekä uusia mikroemulsioihin p ohjautuvia geelejä
US5441986A (en) 1994-07-19 1995-08-15 Pfizer Inc. Estrogen agonists as remedies for prostate and cardiovascular diseases
GB9418067D0 (en) 1994-09-07 1994-10-26 Orion Yhtymae Oy Triphenylethylenes for the prevention and treatment of osteoporosis
US5658931A (en) 1994-09-20 1997-08-19 Eli Lilly And Company Method for inhibiting mammalian breast carcinoma with tamoxifen, and analogs thereof, and certain naphthyl compounds
US6562862B1 (en) 1994-10-20 2003-05-13 Eli Lilly And Company Methods of inhibiting physiological conditions associated with an excess of neuropeptide Y
MX9703944A (es) 1994-11-29 1998-05-31 Hoechst Marion Roussel Inc Metodo para usar derivados de triaril-etileno en el tratamiento y prevencion de osteoporosis.
US5821254A (en) 1995-02-17 1998-10-13 The United States Of America As Represented By The Department Of Health And Human Services Uses of 9-cis-retinoic acids and derivatives thereof alone or in combination with antineoplastic agents in the prevention or treatment of cancer
GB9509572D0 (en) 1995-05-11 1995-07-05 Cancer Res Campaign Tech Cancer therapy
DE19526146A1 (de) 1995-07-07 1997-01-09 Schering Ag Triphenylethylene, Verfahren zu deren Herstellung, diese Triphenylethylene enthaltene pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
US5747059A (en) 1996-01-11 1998-05-05 Novo Nordisk A/S Atrophy of skin/mucous membrane
GB9604577D0 (en) 1996-03-04 1996-05-01 Orion Yhtymae Oy Serum cholesterol lowering agent
DE19653736C2 (de) 1996-12-12 2002-11-21 Lancaster Group Gmbh Kosmetisches Präparat mit Peptidzusatz
GB9803521D0 (en) 1998-02-19 1998-04-15 Orion Yhtymo Oy New compounds and pharmaceutical compositions thereof
US6632447B1 (en) 1998-05-07 2003-10-14 The University Of Tennessee Research Corporation Method for chemoprevention of prostate cancer
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US6525084B2 (en) 1998-07-23 2003-02-25 Novo Nordisk A/S Stable pharmaceutical formulation
US6245352B1 (en) 1999-04-27 2001-06-12 Eli Lilly And Company Pharmaceutical formulation
TW593256B (en) * 1999-11-16 2004-06-21 Hormos Medical Oy Ltd Triphenylalkene derivatives and their use as selective estrogen receptor modulators
CO5271697A1 (es) 2000-01-12 2003-04-30 Pfizer Prod Inc Composiciones y procedimientos para el tratamiento de afecciones que responden a un aumento de testosterona
CA2395730A1 (en) 2000-01-28 2001-08-02 Endorecherche, Inc. Selective estrogen receptor modulators in combination with estrogens
US20010034340A1 (en) 2000-03-20 2001-10-25 American Home Products Corporation Hormone replacement therapy
US6245819B1 (en) 2000-07-21 2001-06-12 Hormos Medical Oy, Ltd. Method for the treatment of vaginal dryness and sexual dysfunction in women during or after the menopause
US6514898B2 (en) * 2000-12-15 2003-02-04 Shell Oil Company Process of preparing a fluid rare earth alkoxylation catalyst
FI111710B (fi) * 2001-05-04 2003-09-15 Hormos Medical Oy Ltd Menetelmä terapeuttisesti aktiivisen yhdisteen valmistamiseksi
CA2458452C (en) 2001-08-10 2011-04-19 Takeda Chemical Industries, Ltd. Gnrh agonist combination drugs
SI1460969T1 (sl) 2001-11-29 2008-10-31 Gtx Inc Preprečevanje in zdravljenje s pomanjkanjem androgena inducirane osteoporoze
US20070197664A1 (en) 2001-11-29 2007-08-23 Steiner Mitchell S Prevention and treatment of androgen-deprivation induced osteoporosis
ATE344025T1 (de) 2002-06-06 2006-11-15 Hormos Medical Ltd Behandlung oder prävention von urogenitaler atrophie und deren symptomen bei frauen
US20040248989A1 (en) 2003-06-05 2004-12-09 Risto Santti Method for the treatment or prevention of lower urinary tract symptoms
US8236861B2 (en) 2004-02-13 2012-08-07 Hormos Medical Corporation Method for enhancing the bioavailablity of ospemifene
US20050187302A1 (en) 2004-02-23 2005-08-25 Hormos Medical Corporation Method for treatment or prevention of osteoporosis in individuals with high bone turnover
US8642079B2 (en) 2004-02-23 2014-02-04 Hormos Medical Corporation Solid formulations of ospemifene
EP1727802A1 (en) 2004-02-25 2006-12-06 Smithkline Beecham Corporation Substituted quinoline compounds for use as selective estrogen receptor modulator
US8758821B2 (en) 2004-05-04 2014-06-24 Hormos Medical Ltd. Oral formulations of ospemifene
MX2007002606A (es) 2004-09-03 2007-05-15 Hormos Medical Ltd Uso de un modulador del receptor selectivo a estrogeno para la elaboracion de una preparacion farmaceutica para uso en un metodo para el tratamiento o prevencion de la deficiencia de androgenos.
WO2008099059A1 (en) 2007-02-14 2008-08-21 Hormos Medical Ltd Method for the preparation of therapeutically valuable triphenylbutene derivatives
WO2008099060A2 (en) 2007-02-14 2008-08-21 Hormos Medical Ltd Methods for the preparation of fispemifene from ospemifene

Also Published As

Publication number Publication date
EP2121553A1 (en) 2009-11-25
US20080207956A1 (en) 2008-08-28
CA2677861A1 (en) 2008-08-21
RU2465261C2 (ru) 2012-10-27
AU2008214530B2 (en) 2012-04-26
MX2009008660A (es) 2009-10-13
EP2821385A2 (en) 2015-01-07
EP2518039B1 (en) 2014-08-27
HK1139379A1 (en) 2010-09-17
EP2518039B8 (en) 2014-12-17
US8293947B2 (en) 2012-10-23
RU2009134131A (ru) 2011-03-20
KR101510646B1 (ko) 2015-04-10
CA2677861C (en) 2015-05-19
HRP20141107T1 (hr) 2015-01-02
DK2121553T3 (da) 2012-07-23
JP5363344B2 (ja) 2013-12-11
ES2389961T3 (es) 2012-11-05
ES2590262T3 (es) 2016-11-21
WO2008099059A1 (en) 2008-08-21
EP2821385B1 (en) 2016-07-27
US20110015448A1 (en) 2011-01-20
HK1206003A1 (zh) 2015-12-31
SI2121553T1 (sl) 2012-11-30
BRPI0823326A2 (pt) 2013-10-15
BRPI0807675B1 (pt) 2021-05-18
PT2121553E (pt) 2012-07-26
JP2010518150A (ja) 2010-05-27
PL2121553T3 (pl) 2012-11-30
EP2518039A9 (en) 2013-02-13
ES2524002T3 (es) 2014-12-03
US7812197B2 (en) 2010-10-12
BRPI0823326B1 (pt) 2021-06-29
CN101636372A (zh) 2010-01-27
BRPI0807675A2 (pt) 2011-09-13
CN101636372B (zh) 2013-03-27
SI2518039T1 (sl) 2015-02-27
EP2821385A3 (en) 2015-02-25
EP2121553B1 (en) 2012-06-27
KR20090110862A (ko) 2009-10-22
EP2518039A1 (en) 2012-10-31
AU2008214530A1 (en) 2008-08-21

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