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MX339300B - Inhibidores de molecula pequeña de la activacion n-terminal del receptor de androgenos. - Google Patents

Inhibidores de molecula pequeña de la activacion n-terminal del receptor de androgenos.

Info

Publication number
MX339300B
MX339300B MX2011001890A MX2011001890A MX339300B MX 339300 B MX339300 B MX 339300B MX 2011001890 A MX2011001890 A MX 2011001890A MX 2011001890 A MX2011001890 A MX 2011001890A MX 339300 B MX339300 B MX 339300B
Authority
MX
Mexico
Prior art keywords
small molecule
androgen receptor
molecule inhibitors
compounds
terminus
Prior art date
Application number
MX2011001890A
Other languages
English (en)
Other versions
MX2011001890A (es
Inventor
Marianne D Sadar
Nasrin R Mawji
Wangjun
Raymond J Anderson
David E Williams
Mike Leblanc
lu-ping Yan
Original Assignee
British Columbia Cancer Agency
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41706796&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX339300(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by British Columbia Cancer Agency filed Critical British Columbia Cancer Agency
Publication of MX2011001890A publication Critical patent/MX2011001890A/es
Publication of MX339300B publication Critical patent/MX339300B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)

Abstract

La presente invención se refiere a compuestos que tienen una estructura de Fórmula (A). Se proporcionan usos de dichos compuestos para el tratamiento de varias indicaciones, incluyendo cáncer de próstata, así como métodos de tratamiento que involucran dichos compuestos. También se proporcionan usos de compuestos que tienen una estructura de Fórmula (F) para el tratamiento de varias indicaciones, incluyendo cáncer de próstata, así como métodos de tratamiento que involucran dichos compuestos.
MX2011001890A 2008-08-22 2009-08-24 Inhibidores de molecula pequeña de la activacion n-terminal del receptor de androgenos. MX339300B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13627708P 2008-08-22 2008-08-22
PCT/CA2009/001173 WO2010020055A1 (en) 2008-08-22 2009-08-24 Small molecule inhibitors of n-terminus activation of the androgen receptor

Publications (2)

Publication Number Publication Date
MX2011001890A MX2011001890A (es) 2011-06-20
MX339300B true MX339300B (es) 2016-05-19

Family

ID=41706796

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011001890A MX339300B (es) 2008-08-22 2009-08-24 Inhibidores de molecula pequeña de la activacion n-terminal del receptor de androgenos.

Country Status (14)

Country Link
US (2) US9487479B2 (es)
EP (1) EP2331501B1 (es)
JP (1) JP2012500778A (es)
CN (1) CN102131775B (es)
AU (1) AU2009284668B2 (es)
BR (1) BRPI0917818A2 (es)
CA (1) CA2728103C (es)
CL (1) CL2011000341A1 (es)
CO (1) CO6351779A2 (es)
ES (1) ES2593859T3 (es)
HK (1) HK1153198A1 (es)
MX (1) MX339300B (es)
RU (1) RU2519948C2 (es)
WO (1) WO2010020055A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012500778A (ja) 2008-08-22 2012-01-12 ブリティッシュ コロンビア キャンサー エージェンシー ブランチ アンドロゲン受容体のｎ末端の活性化の小分子阻害剤
US9682933B2 (en) * 2014-05-30 2017-06-20 British Columbia Cancer Agency Branch Androgen receptor modulators and methods for their use
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
US10799416B2 (en) * 2017-01-11 2020-10-13 Jonathan Taves Self-treating upper neck system for therapeutic mobilization
CN107353239B (zh) 2017-08-11 2019-06-18 北京卓凯生物技术有限公司 4-氧-烷基化特特拉姆酸类化合物及其制备方法
CN107468690B (zh) * 2017-08-11 2020-01-31 北京卓凯生物技术有限公司 4-氧-烷基化特特拉姆酸类化合物及其制备方法与应用
RU2694373C2 (ru) * 2017-10-16 2019-07-12 Федеральное государственное бюджетное образовательное учреждение высшего образования "Кировский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО Кировский ГМУ Минздрава России) Способ лечения кастрационно-устойчивого рака простаты
RU2694259C2 (ru) * 2017-10-16 2019-07-11 Федеральное государственное бюджетное образовательное учреждение высшего образования "Кировский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО Кировский ГМУ Минздрава России) Способ лечения кастрационно-устойчивого рака простаты
RU2696287C2 (ru) * 2017-10-16 2019-08-01 Федеральное государственное бюджетное образовательное учреждение высшего образования "Кировский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО Кировский ГМУ Минздрава России) Способ лечения кастрационно-устойчивого рака простаты
RU2700573C2 (ru) * 2017-10-16 2019-09-18 Федеральное государственное бюджетное образовательное учреждение высшего образования "Кировский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО Кировский ГМУ Минздрава России) Способ лечения кастрационно-устойчивого рака простаты

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0317057A (ja) * 1989-06-15 1991-01-25 Fujisawa Pharmaceut Co Ltd 新規５員環複素環化合物
AU4494399A (en) 1998-06-30 2000-01-24 University Of British Columbia, The Inhibitors of androgen-independent activation of androgen receptor
RU2269520C2 (ru) * 2000-05-09 2006-02-10 Эдфарма, Инк. Соединения пиперазиндиона
GB0130677D0 (en) * 2001-12-21 2002-02-06 Glaxo Group Ltd Medicaments and novel compounds
US7772433B2 (en) 2002-02-28 2010-08-10 University Of Tennessee Research Foundation SARMS and method of use thereof
JP2012500778A (ja) 2008-08-22 2012-01-12 ブリティッシュ コロンビア キャンサー エージェンシー ブランチ アンドロゲン受容体のｎ末端の活性化の小分子阻害剤
US9682933B2 (en) * 2014-05-30 2017-06-20 British Columbia Cancer Agency Branch Androgen receptor modulators and methods for their use

Also Published As

Publication number Publication date
AU2009284668A1 (en) 2010-02-25
CN102131775B (zh) 2015-12-16
RU2011110743A (ru) 2012-09-27
HK1153198A1 (zh) 2012-03-23
MX2011001890A (es) 2011-06-20
ES2593859T3 (es) 2016-12-13
CA2728103C (en) 2017-06-27
CL2011000341A1 (es) 2011-09-02
CO6351779A2 (es) 2011-12-20
US20170239216A1 (en) 2017-08-24
US9487479B2 (en) 2016-11-08
JP2012500778A (ja) 2012-01-12
BRPI0917818A2 (pt) 2017-02-21
EP2331501A4 (en) 2012-06-06
CA2728103A1 (en) 2010-02-25
WO2010020055A1 (en) 2010-02-25
EP2331501A1 (en) 2011-06-15
AU2009284668B2 (en) 2015-07-09
CN102131775A (zh) 2011-07-20
EP2331501B1 (en) 2016-07-20
RU2519948C2 (ru) 2014-06-20
US20110230539A1 (en) 2011-09-22

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