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CY1108467T1 - Συνθεσεις και μεθοδοι για σταθεροποιηση τρανσθυρετινης και παρεμποδιση εσφαλμενης αναδιπλωσης τρανσθυρετινης - Google Patents

Συνθεσεις και μεθοδοι για σταθεροποιηση τρανσθυρετινης και παρεμποδιση εσφαλμενης αναδιπλωσης τρανσθυρετινης

Info

Publication number
CY1108467T1
CY1108467T1 CY20081101229T CY081101229T CY1108467T1 CY 1108467 T1 CY1108467 T1 CY 1108467T1 CY 20081101229 T CY20081101229 T CY 20081101229T CY 081101229 T CY081101229 T CY 081101229T CY 1108467 T1 CY1108467 T1 CY 1108467T1
Authority
CY
Cyprus
Prior art keywords
methods
transthyretin
stabilization
transythretine
transfithretine
Prior art date
Application number
CY20081101229T
Other languages
English (en)
Inventor
Jeffrey W Kelly
Evan T Powers
Hossein Razavi
Original Assignee
The Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32685364&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1108467(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by The Scripps Research Institute filed Critical The Scripps Research Institute
Publication of CY1108467T1 publication Critical patent/CY1108467T1/el

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Κινητική σταθεροποίηση της φυσικής κατάστασης τρανσθυρετίνης είναι ένας αποτελεσματικός μηχανισμός για αποτροπή εσφαλμένης αναδίπλωσης πρωτεΐνης. Επειδή η εσφαλμένη αναδίπλωση τρανσθυρετίνης παίζει ένα σημαντικό ρόλο στις αμυλοειδείς ασθένειες τρανσθυρετίνης, παρεμπόδιση τέτοιας εσφαλμένης αναδίπλωσης μπορεί να χρησιμοποιηθεί ως αποτελεσματική θεραπεία ή προφύλαξη για τέτοιες ασθένειες. Αποκαλύπτονται μέθοδοι θεραπευτικής αγωγής, μέθοδοι συστηματικής εξέτασης καθώς επίσης ειδικές σταθεροποιητικές τρανσθυρετίνης ενώσεις.
CY20081101229T 2002-12-19 2008-10-30 Συνθεσεις και μεθοδοι για σταθεροποιηση τρανσθυρετινης και παρεμποδιση εσφαλμενης αναδιπλωσης τρανσθυρετινης CY1108467T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43507902P 2002-12-19 2002-12-19
US46543503P 2003-04-24 2003-04-24
EP03813782A EP1587821B1 (en) 2002-12-19 2003-12-19 Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding

Publications (1)

Publication Number Publication Date
CY1108467T1 true CY1108467T1 (el) 2014-04-09

Family

ID=32685364

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20081101229T CY1108467T1 (el) 2002-12-19 2008-10-30 Συνθεσεις και μεθοδοι για σταθεροποιηση τρανσθυρετινης και παρεμποδιση εσφαλμενης αναδιπλωσης τρανσθυρετινης
CY2012005C CY2012005I2 (el) 2002-12-19 2012-01-30 Συνθεσεις και μεθοδοι για σταθεροποιηση τρανσθυρετινης και παρεμποδιση εσφαλμενης αναδιπλωσης τρανσθυρετινης

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY2012005C CY2012005I2 (el) 2002-12-19 2012-01-30 Συνθεσεις και μεθοδοι για σταθεροποιηση τρανσθυρετινης και παρεμποδιση εσφαλμενης αναδιπλωσης τρανσθυρετινης

Country Status (19)

Country Link
US (6) US7214695B2 (el)
EP (3) EP1587821B1 (el)
JP (3) JP4665076B2 (el)
KR (1) KR101089904B1 (el)
CN (2) CN101413143B (el)
AT (2) ATE524741T1 (el)
AU (2) AU2003303196C1 (el)
BE (1) BE2012C008I2 (el)
BR (1) BRPI0317463B8 (el)
CA (2) CA2800237C (el)
CY (2) CY1108467T1 (el)
DE (2) DE60323155D1 (el)
DK (2) DK1988397T3 (el)
ES (3) ES2524803T3 (el)
FR (1) FR12C0008I2 (el)
LU (1) LU91935I2 (el)
PT (2) PT1587821E (el)
SI (1) SI1587821T1 (el)
WO (1) WO2004056315A2 (el)

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