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MX2014003043A - Formas solidas de un inhibidor de disociacion transtiretina. - Google Patents

Formas solidas de un inhibidor de disociacion transtiretina.

Info

Publication number
MX2014003043A
MX2014003043A MX2014003043A MX2014003043A MX2014003043A MX 2014003043 A MX2014003043 A MX 2014003043A MX 2014003043 A MX2014003043 A MX 2014003043A MX 2014003043 A MX2014003043 A MX 2014003043A MX 2014003043 A MX2014003043 A MX 2014003043A
Authority
MX
Mexico
Prior art keywords
solid forms
transthyretin
dissociation inhibitor
solid
dissociation
Prior art date
Application number
MX2014003043A
Other languages
English (en)
Inventor
Richard Frederic Labaudiniere
Michael Henry O'neill
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MX2014003043A publication Critical patent/MX2014003043A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

La presente invención se refiere a formas sólidas de la sal de N-metil-D-glucamina (meglumina) de 6-carboxi-2-(3,5-diclorofenil)- benzoxazol y a métodos para su preparación. La invención también se dirige a composiciones farmacéuticas que contienen al menos una forma sólida y al uso terapéutico o profiláctico de tales formas sólidas y composiciones.
MX2014003043A 2011-09-16 2012-09-12 Formas solidas de un inhibidor de disociacion transtiretina. MX2014003043A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161535551P 2011-09-16 2011-09-16
PCT/IB2012/054748 WO2013038351A1 (en) 2011-09-16 2012-09-12 Solid forms of a transthyretin dissociation inhibitor

Publications (1)

Publication Number Publication Date
MX2014003043A true MX2014003043A (es) 2015-02-05

Family

ID=47116132

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014003043A MX2014003043A (es) 2011-09-16 2012-09-12 Formas solidas de un inhibidor de disociacion transtiretina.

Country Status (16)

Country Link
US (2) US9249112B2 (es)
EP (1) EP2755961A1 (es)
JP (2) JP5869677B2 (es)
KR (1) KR20140054231A (es)
CN (1) CN103781770B (es)
AR (1) AR088755A1 (es)
AU (1) AU2012310157B2 (es)
BR (1) BR112014005810A2 (es)
CA (1) CA2847293C (es)
IL (1) IL231472A0 (es)
MX (1) MX2014003043A (es)
RU (1) RU2586330C2 (es)
SG (1) SG2014013270A (es)
TW (2) TWI476185B (es)
WO (1) WO2013038351A1 (es)
ZA (1) ZA201401202B (es)

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US9770441B1 (en) * 2014-09-08 2017-09-26 Pfizer Inc. Crystalline solid forms of 6-carboxy-2-(3,5-dichlorophenyl)-benzoxazole
CN107344927A (zh) 2016-05-05 2017-11-14 苏州晶云药物科技有限公司 Tafamidis葡甲胺盐的晶型E及其制备方法和用途
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JP2022534420A (ja) * 2019-05-31 2022-07-29 プレックス ファーマスーティカルズ，インク 眼のタンパク質凝集疾患を治療するための薬剤
WO2021019448A1 (en) * 2019-08-01 2021-02-04 Honour (R&D) Process for the preparation of transthyretin dissociation inhibitor
WO2021093809A1 (zh) 2019-11-15 2021-05-20 苏州科睿思制药有限公司 他发米帝司的晶型及其制备方法和用途
AU2020406455B2 (en) * 2019-12-20 2024-02-15 Pfizer Ireland Pharmaceuticals Efficient process for making 6-carboxy benzoxazole derivatives
WO2021232619A1 (zh) * 2020-05-19 2021-11-25 苏州科睿思制药有限公司 一种他发米帝司游离酸的晶型及其制备方法和用途
WO2022009221A1 (en) * 2020-07-04 2022-01-13 Nuray Chemicals Private Limited Solid state forms of 6-carboxy-2-(3, 5-dichlorophenyl)-benzoxazole of formula-i and pharmaceutically acceptable salts thereof
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Also Published As

Publication number Publication date
JP5869677B2 (ja) 2016-02-24
KR20140054231A (ko) 2014-05-08
AR088755A1 (es) 2014-07-02
US20160185739A1 (en) 2016-06-30
TW201516039A (zh) 2015-05-01
WO2013038351A1 (en) 2013-03-21
SG2014013270A (en) 2014-05-29
JP2016128444A (ja) 2016-07-14
CN103781770A (zh) 2014-05-07
AU2012310157A1 (en) 2014-04-03
ZA201401202B (en) 2016-01-27
CA2847293A1 (en) 2013-03-21
RU2014109676A (ru) 2015-10-27
TW201315720A (zh) 2013-04-16
NZ621194A (en) 2016-02-26
BR112014005810A2 (pt) 2017-03-28
CN103781770B (zh) 2016-04-13
TWI538909B (zh) 2016-06-21
TWI476185B (zh) 2015-03-11
CA2847293C (en) 2017-03-28
US9249112B2 (en) 2016-02-02
RU2586330C2 (ru) 2016-06-10
IL231472A0 (en) 2014-04-30
AU2012310157B2 (en) 2015-11-12
HK1197239A1 (zh) 2015-01-09
JP2014526498A (ja) 2014-10-06
EP2755961A1 (en) 2014-07-23
US20150031735A1 (en) 2015-01-29

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