JO3148B1 - مركب مثبط لإشارات مسار notch - Google Patents
مركب مثبط لإشارات مسار notchInfo
- Publication number
- JO3148B1 JO3148B1 JOP/2012/0190A JOP20120190A JO3148B1 JO 3148 B1 JO3148 B1 JO 3148B1 JO P20120190 A JOP20120190 A JO P20120190A JO 3148 B1 JO3148 B1 JO 3148B1
- Authority
- JO
- Jordan
- Prior art keywords
- signaling inhibitor
- notch pathway
- pathway signaling
- inhibitor compound
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
Abstract
يوفر الاختراع الحالي مركب، أو ملح أو هيدرات مقبولين صيدليًا، وتركيبة صيدلية تحتوي على المركب المذكور، أو ملح أو هيدرات مقبولين صيدليًا، ويكون مفيدًا كمثبِّط لإشارات مسار Notch لعلاج السرطان.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161512016P | 2011-07-27 | 2011-07-27 | |
| US201161560486P | 2011-11-16 | 2011-11-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JO3148B1 true JO3148B1 (ar) | 2017-09-20 |
Family
ID=46598983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JOP/2012/0190A JO3148B1 (ar) | 2011-07-27 | 2012-07-10 | مركب مثبط لإشارات مسار notch |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US8569286B2 (ar) |
| EP (1) | EP2736920B1 (ar) |
| JP (1) | JP6027110B2 (ar) |
| KR (1) | KR101578309B1 (ar) |
| CN (1) | CN103732612B (ar) |
| AP (1) | AP4080A (ar) |
| AR (1) | AR087107A1 (ar) |
| AU (1) | AU2012287251B2 (ar) |
| BR (1) | BR112014001600B1 (ar) |
| CA (1) | CA2841178C (ar) |
| CL (1) | CL2014000175A1 (ar) |
| CO (1) | CO6862159A2 (ar) |
| CR (1) | CR20140036A (ar) |
| CY (1) | CY1116645T1 (ar) |
| DK (1) | DK2736920T3 (ar) |
| DO (1) | DOP2014000011A (ar) |
| EA (1) | EA023044B1 (ar) |
| EC (1) | ECSP14013179A (ar) |
| ES (1) | ES2544937T3 (ar) |
| GT (1) | GT201400012A (ar) |
| HK (1) | HK1194086A1 (ar) |
| HR (1) | HRP20150771T1 (ar) |
| HU (1) | HUE027534T2 (ar) |
| IL (1) | IL229988A (ar) |
| JO (1) | JO3148B1 (ar) |
| MA (1) | MA35611B1 (ar) |
| ME (1) | ME02171B (ar) |
| MX (1) | MX356536B (ar) |
| MY (1) | MY184303A (ar) |
| PE (1) | PE20141061A1 (ar) |
| PL (1) | PL2736920T3 (ar) |
| PT (1) | PT2736920E (ar) |
| RS (1) | RS54135B1 (ar) |
| SI (1) | SI2736920T1 (ar) |
| TW (1) | TWI568730B (ar) |
| WO (1) | WO2013016081A1 (ar) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014110506A2 (en) * | 2013-01-14 | 2014-07-17 | The Trustees Of Columbia University In The City Of New York | Methods of treating, preventing and diagnosing leukemia and other blood diseases and disorders |
| EP3024456A4 (en) | 2013-07-26 | 2017-04-12 | Update Pharma Inc. | Combinatorial methods to improve the therapeutic benefit of bisantrene |
| TWI704151B (zh) | 2014-12-22 | 2020-09-11 | 美商美國禮來大藥廠 | Ｅｒｋ抑制劑 |
| TWI609687B (zh) * | 2015-04-14 | 2018-01-01 | 美國禮來大藥廠 | 平滑肌肉瘤之標靶性治療 |
| JO3491B1 (ar) * | 2015-07-07 | 2020-07-05 | Audion Therapeutics | مركبات مثبطة لإشارات مسار notch |
| CA3012832A1 (en) | 2016-02-05 | 2017-08-10 | Denali Therapeutics Inc. | N-azepinyl-carboxamide inhibitors of receptor-interacting protein kinase1 |
| AU2017233898B2 (en) | 2016-03-15 | 2022-12-15 | Oryzon Genomics, S.A. | Combinations of LSD1 inhibitors for use in the treatment of solid tumors |
| RU2754452C2 (ru) * | 2016-04-12 | 2021-09-02 | Эли Лилли Энд Компани | Комбинированная терапия ингибиторами notch и pi3k/mtor для применения в лечении рака |
| WO2017180389A1 (en) | 2016-04-12 | 2017-10-19 | Eli Lilly And Company | Combination therapy with notch and cdk4/6 inhibitors for the treatment of cancer |
| US10688104B2 (en) * | 2016-05-20 | 2020-06-23 | Eli Lilly And Company | Combination therapy with Notch and PD-1 or PD-L1 inhibitors |
| AU2017321011B2 (en) | 2016-08-31 | 2023-08-03 | Eli Lilly And Company | Dosage regimen for treatment of solid tumors |
| US11376259B2 (en) | 2016-10-12 | 2022-07-05 | Eli Lilly And Company | Targeted treatment of mature T-cell lymphoma |
| PL3552017T3 (pl) | 2016-12-09 | 2022-08-08 | Denali Therapeutics Inc. | Związki użyteczne jako inhibitory RIPK1 |
| US11845803B2 (en) | 2017-02-17 | 2023-12-19 | Fred Hutchinson Cancer Center | Combination therapies for treatment of BCMA-related cancers and autoimmune disorders |
| AU2018360800B2 (en) | 2017-11-01 | 2024-11-21 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for B-cell maturation antigen (BCMA) |
| AU2018359907A1 (en) | 2017-11-06 | 2020-05-07 | Fred Hutchinson Cancer Center | Combination of a cell therapy and a gamma secretase inhibitor |
| MX2020011826A (es) * | 2018-05-06 | 2021-01-15 | Ayala Pharmaceuticals Inc | Composiciones de combinacion que comprenden compuestos de bisfluoroalquil-1,4-benzodiazepinona y metodos de uso de las mismas. |
| WO2020072601A1 (en) | 2018-10-02 | 2020-04-09 | Frequency Therapeutics, Inc. | Pharmaceutical compositions comprising otic therapeutic agents and related methods |
| AU2020271067A1 (en) | 2019-04-08 | 2021-11-25 | Frequency Therapeutics, Inc. | Combination of CHIR99021 and valproic acid for treating hearing loss |
| AU2023206890A1 (en) | 2022-01-12 | 2024-08-22 | Denali Therapeutics Inc. | Crystalline forms of (s)-5-benzyl-n-(5-methyl-4-oxo-2, 3,4,5- tetrahydropyrido [3,2-b] [l,4]oxazepin-3-yl)-4h-l,2,4-triazole-3-carboxamide |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA9711537B (en) * | 1996-12-23 | 1998-06-25 | Athena Neurosciences Inc Eli L | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting ß-amyloid peptide release and/or its synthesis by use of such compounds. |
| AU4710199A (en) * | 1998-06-22 | 2000-01-10 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
| AU4707999A (en) | 1998-06-22 | 2000-01-10 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
| MXPA05008172A (es) | 2003-02-04 | 2005-10-05 | Hoffmann La Roche | Derivados de malonamida como inhibidores gamma-secretasa. |
| KR100838852B1 (ko) | 2003-09-09 | 2008-06-16 | 에프. 호프만-라 로슈 아게 | 감마-세크리테이즈의 활성을 차단하는 말론아미드 유도체 |
| CN1894217B (zh) | 2003-10-06 | 2011-09-21 | 弗·哈夫曼-拉罗切有限公司 | 用作γ-分泌酶抑制剂的取代的二苯并氮杂*和苯并二氮杂* |
| BRPI0709773B8 (pt) | 2006-03-27 | 2021-05-25 | Hoffmann La Roche | derivados de malonamida, processo de produção do mesmo, medicamento, e seus usos como inibidores de gama-secretase no tratamento do mal de alzheimer |
| KR101150574B1 (ko) * | 2007-02-02 | 2012-05-30 | 에프. 호프만-라 로슈 아게 | 6-옥소-6,7-다이하이드로-5ｈ-다이벤조［ｂ,ｄ］아제핀-7-일 유도체 |
| AU2009203776A1 (en) | 2008-01-11 | 2009-07-16 | F. Hoffmann-La Roche Ag | Use of a gamma-secretase inhibitor for treating cancer |
| US8637493B2 (en) * | 2009-11-12 | 2014-01-28 | University Of Massachusetts | Methods for treating glioblastoma |
-
2012
- 2012-07-10 JO JOP/2012/0190A patent/JO3148B1/ar active
- 2012-07-10 AR ARP120102486A patent/AR087107A1/es not_active Application Discontinuation
- 2012-07-13 TW TW101125459A patent/TWI568730B/zh active
- 2012-07-18 ME MEP-2015-105A patent/ME02171B/me unknown
- 2012-07-18 EA EA201490161A patent/EA023044B1/ru not_active IP Right Cessation
- 2012-07-18 AU AU2012287251A patent/AU2012287251B2/en active Active
- 2012-07-18 HU HUE12741192A patent/HUE027534T2/en unknown
- 2012-07-18 WO PCT/US2012/047100 patent/WO2013016081A1/en active Application Filing
- 2012-07-18 RS RS20150496A patent/RS54135B1/en unknown
- 2012-07-18 PT PT127411924T patent/PT2736920E/pt unknown
- 2012-07-18 DK DK12741192.4T patent/DK2736920T3/en active
- 2012-07-18 MX MX2014001084A patent/MX356536B/es active IP Right Grant
- 2012-07-18 AP AP2014007362A patent/AP4080A/en active
- 2012-07-18 JP JP2014522877A patent/JP6027110B2/ja active Active
- 2012-07-18 BR BR112014001600-3A patent/BR112014001600B1/pt active IP Right Grant
- 2012-07-18 SI SI201230246T patent/SI2736920T1/sl unknown
- 2012-07-18 ES ES12741192.4T patent/ES2544937T3/es active Active
- 2012-07-18 CA CA2841178A patent/CA2841178C/en active Active
- 2012-07-18 US US13/551,681 patent/US8569286B2/en active Active
- 2012-07-18 KR KR1020147001731A patent/KR101578309B1/ko active IP Right Grant
- 2012-07-18 MY MYPI2014700183A patent/MY184303A/en unknown
- 2012-07-18 PE PE2014000129A patent/PE20141061A1/es active IP Right Grant
- 2012-07-18 PL PL12741192T patent/PL2736920T3/pl unknown
- 2012-07-18 CN CN201280037471.9A patent/CN103732612B/zh active Active
- 2012-07-18 EP EP12741192.4A patent/EP2736920B1/en active Active
-
2013
- 2013-12-17 IL IL229988A patent/IL229988A/en active IP Right Grant
-
2014
- 2014-01-22 DO DO2014000011A patent/DOP2014000011A/es unknown
- 2014-01-22 MA MA36712A patent/MA35611B1/fr unknown
- 2014-01-23 CL CL2014000175A patent/CL2014000175A1/es unknown
- 2014-01-24 CR CR20140036A patent/CR20140036A/es unknown
- 2014-01-24 GT GT201400012A patent/GT201400012A/es unknown
- 2014-01-24 CO CO14014585A patent/CO6862159A2/es active IP Right Grant
- 2014-01-27 EC ECSP14013179 patent/ECSP14013179A/es unknown
- 2014-07-22 HK HK14107480.6A patent/HK1194086A1/xx unknown
-
2015
- 2015-07-14 HR HRP20150771TT patent/HRP20150771T1/hr unknown
- 2015-08-25 CY CY20151100742T patent/CY1116645T1/el unknown
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