PT2699264T - Anticorpos e outras moléculas que ligam b7-h1 e pd-1 - Google Patents

Anticorpos e outras moléculas que ligam b7-h1 e pd-1

Info

Publication number: PT2699264T
Authority: PT; Portugal
Prior art keywords: antibodies; molecules connecting; molecules
Prior art date: 2011-04-20

Application number

PT127747244T

Other languages

English (en)

Inventor

Langermann Solomon

Liu Linda

Marshall Shannon

Yao Sheng

Original Assignee

Medimmune Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-04-20

Filing date

2012-04-19

Publication date

2018-05-23

2012-04-19 Application filed by Medimmune Llc filed Critical Medimmune Llc

2018-05-23 Publication of PT2699264T publication Critical patent/PT2699264T/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Mycology (AREA)
Epidemiology (AREA)
Cell Biology (AREA)
Physics & Mathematics (AREA)
Endocrinology (AREA)
Pathology (AREA)
General Physics & Mathematics (AREA)
Biotechnology (AREA)
Analytical Chemistry (AREA)
Food Science & Technology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Transplantation (AREA)
Peptides Or Proteins (AREA)

PT127747244T 2011-04-20 2012-04-19 Anticorpos e outras moléculas que ligam b7-h1 e pd-1 PT2699264T (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201161477414P	2011-04-20	2011-04-20

Publications (1)

Publication Number	Publication Date
PT2699264T true PT2699264T (pt)	2018-05-23

Family

ID=47041916

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT127747244T PT2699264T (pt)	2011-04-20	2012-04-19	Anticorpos e outras moléculas que ligam b7-h1 e pd-1

Country Status (21)

Country	Link
US (2)	US9205148B2 (pt)
EP (2)	EP3403672A1 (pt)
JP (2)	JP6072771B2 (pt)
KR (1)	KR101970025B1 (pt)
CN (1)	CN103608040B (pt)
AU (1)	AU2012245477C1 (pt)
CA (1)	CA2833636A1 (pt)
CY (1)	CY1120626T1 (pt)
DK (1)	DK2699264T3 (pt)
ES (1)	ES2669310T3 (pt)
HR (1)	HRP20180893T1 (pt)
HU (1)	HUE037651T2 (pt)
LT (1)	LT2699264T (pt)
MX (1)	MX338353B (pt)
PL (1)	PL2699264T3 (pt)
PT (1)	PT2699264T (pt)
RS (1)	RS57324B1 (pt)
RU (1)	RU2625034C2 (pt)
SI (1)	SI2699264T1 (pt)
SM (1)	SMT201800294T1 (pt)
WO (1)	WO2012145493A1 (pt)

Families Citing this family (757)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUE032025T2 (en)	2008-01-31	2017-08-28	Inserm - Inst Nat De La Sante Et De La Rech Medicale	Antibodies to human CD39 and their use to inhibit regulatory T cell activity
EP4331604B1 (en)	2008-12-09	2025-03-05	F. Hoffmann-La Roche AG	Anti-pd-l1 antibodies and their use to enhance t-cell function
JP2013532153A (ja)	2010-06-18	2013-08-15	ザブリガムアンドウィメンズホスピタルインコーポレイテッド	慢性免疫病に対する免疫治療のためのｔｉｍ−３およびｐｄ−１に対する二重特異性抗体
EP3409278B8 (en)	2011-07-21	2020-11-04	Sumitomo Dainippon Pharma Oncology, Inc.	Heterocyclic protein kinase inhibitors
EP2850102A1 (en)	2012-05-15	2015-03-25	Bristol-Myers Squibb Company	Cancer immunotherapy by disrupting pd-1/pd-l1 signaling
CN112587671A (zh)	2012-07-18	2021-04-02	博笛生物科技有限公司	癌症的靶向免疫治疗
EP3263601B1 (en)	2012-10-02	2021-11-24	Bristol-Myers Squibb Company	Combination of anti-kir antibodies and anti-pd-1 antibodies to treat cancer
SG11201504764SA (en) *	2012-12-19	2015-07-30	Amplimmune Inc	Anti-human b7-h4 antibodies and their uses
RU2650756C2 (ru) *	2012-12-21	2018-04-17	МЕДИММЬЮН, ЭлЭлСи	Антитела к h7cr
EP2950814A4 (en)	2013-01-31	2016-06-08	Univ Jefferson	FUSION PROTEINS BASED ON PD-L1 AND PD-L2 AND USES THEREOF
PE20152000A1 (es)	2013-03-06	2016-01-22	Astrazeneca Ab	Inhibidores quinazolinicos de formas mutadas activantes del receptor del factor de crecimiento epidermico
SG11201507333XA (en) *	2013-03-15	2015-10-29	Genentech Inc	Biomarkers and methods of treating pd-1 and pd-l1 related conditions
WO2014194293A1 (en) *	2013-05-30	2014-12-04	Amplimmune, Inc.	Improved methods for the selection of patients for pd-1 or b7-h4 targeted therapies, and combination therapies thereof
WO2014209804A1 (en) *	2013-06-24	2014-12-31	Biomed Valley Discoveries, Inc.	Bispecific antibodies
DK3444271T3 (da)	2013-08-08	2022-01-10	Cytune Pharma	Il-15- og il-15r-alfa-sushi-domænebaserede modulokiner
JP6794255B2 (ja)	2013-08-08	2020-12-02	サイチューンファーマ	組合せ医薬組成物
AR097306A1 (es)	2013-08-20	2016-03-02	Merck Sharp & Dohme	Modulación de la inmunidad tumoral
AU2013400609B9 (en)	2013-09-13	2020-03-05	Beigene Switzerland Gmbh	Anti-PD1 antibodies and their use as therapeutics and diagnostics
EP3683232A1 (en)	2013-09-13	2020-07-22	F. Hoffmann-La Roche AG	Methods and compositions comprising purified recombinant polypeptides
MX2016002799A (es) *	2013-09-13	2016-05-26	Genentech Inc	Composiciones y metodos para detectar y cuantificar la proteina en la celula hospedera en las lineas de celulas y productos de polipeptidos recombinantes.
SMT201900332T1 (it)	2013-09-20	2019-07-11	Bristol Myers Squibb Co	Combinazione di anticorpi anti-lag-3 e anticorpi anti-pd-1 per il trattamento di tumori
WO2015048312A1 (en) *	2013-09-26	2015-04-02	Costim Pharmaceuticals Inc.	Methods for treating hematologic cancers
UA119659C2 (uk)	2013-12-12	2019-07-25	Шанхай Хенжуй Фармасьютикал Ко., Лтд.	Антитіло до pd-1, його антигензв'язуючий фрагмент та їхнє медичне застосування
US20160318928A1 (en)	2013-12-24	2016-11-03	Bristol-Myers Squibb Company	Tricyclic compounds as anticancer agents
EP4056594A1 (en)	2014-01-10	2022-09-14	Birdie Biopharmaceuticals Inc.	Compounds and compositions for immunotherapy
TWI681969B (zh)	2014-01-23	2020-01-11	美商再生元醫藥公司	針對ｐｄ-１的人類抗體
TWI680138B (zh)	2014-01-23	2019-12-21	美商再生元醫藥公司	抗ｐｄ-ｌ１之人類抗體
JOP20200094A1 (ar)	2014-01-24	2017-06-16	Dana Farber Cancer Inst Inc	جزيئات جسم مضاد لـ pd-1 واستخداماتها
JOP20200096A1 (ar)	2014-01-31	2017-06-16	Children’S Medical Center Corp	جزيئات جسم مضاد لـ tim-3 واستخداماتها
GB201403775D0 (en)	2014-03-04	2014-04-16	Kymab Ltd	Antibodies, uses & methods
WO2015134605A1 (en)	2014-03-05	2015-09-11	Bristol-Myers Squibb Company	Treatment of renal cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent
US10618963B2 (en)	2014-03-12	2020-04-14	Yeda Research And Development Co. Ltd	Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS
US10519237B2 (en)	2014-03-12	2019-12-31	Yeda Research And Development Co. Ltd	Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS
US9394365B1 (en)	2014-03-12	2016-07-19	Yeda Research And Development Co., Ltd	Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease
KR20200029627A (ko)	2014-03-12	2020-03-18	예다 리서치 앤드 디벨럽먼트 캄파니 리미티드	Cns의 질환 및 손상을 치료하기 위한 전신적 조절 t 세포 수준 또는 활성의 감소
ME03558B (me)	2014-03-14	2020-07-20	Novartis Ag	Molekuli anti-lag-3 antiтela i njihove upotrebe
US20170158776A1 (en)	2014-05-15	2017-06-08	Bristol-Myers Squibb Company	Treatment of lung cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent
US10987322B2 (en)	2014-06-06	2021-04-27	Flexus Biosciences, Inc.	Immunoregulatory agents
WO2015187835A2 (en)	2014-06-06	2015-12-10	Bristol-Myers Squibb Company	Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof
TWI693232B (zh)	2014-06-26	2020-05-11	美商宏觀基因股份有限公司	與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法
TWI726608B (zh)	2014-07-03	2021-05-01	英屬開曼群島商百濟神州有限公司	抗pd-l1抗體及其作為治療及診斷之用途
EP3166976B1 (en)	2014-07-09	2022-02-23	Birdie Biopharmaceuticals Inc.	Anti-pd-l1 combinations for treating tumors
MX2017000419A (es)	2014-07-11	2017-08-16	Genentech Inc	Anticuerpos anti-pd-l1 y sus usos de diagnóstico.
AU2015292678B2 (en)	2014-07-22	2020-10-22	Cb Therapeutics, Inc.	Anti-PD-1 antibodies
CN105330740B (zh) *	2014-07-30	2018-08-17	珠海市丽珠单抗生物技术有限公司	抗pd-1抗体及其应用
PL3177644T3 (pl)	2014-08-05	2021-06-14	MabQuest SA	Immunologiczne reagenty wiążące do PD-1
JP6909153B2 (ja)	2014-08-05	2021-07-28	アポロミクスインコーポレイテッド	抗ｐｄ−ｌ１抗体
US9982052B2 (en)	2014-08-05	2018-05-29	MabQuest, SA	Immunological reagents
US9546206B2 (en)	2014-08-08	2017-01-17	The Board Of Trustees Of The Leland Stanford Junior University	High affinity PD-1 agents and methods of use
CN112587672A (zh)	2014-09-01	2021-04-02	博笛生物科技有限公司	用于治疗肿瘤的抗-pd-l1结合物
RU2718914C2 (ru)	2014-09-13	2020-04-15	Новартис Аг	Сочетанные способы лечения с использованием ингибиторов alk
HUE051193T2 (hu)	2014-09-16	2021-03-01	Innate Pharma	Gátlási reakcióút semlegesítése limfocitákban
DK3204417T3 (da)	2014-10-10	2020-10-12	Innate Pharma	Cd73-blokering
EP4029508A1 (en)	2014-10-10	2022-07-20	Idera Pharmaceuticals, Inc.	Treatment of cancer using tlr9 agonists and checkpoint inhibitors
CN107001478B (zh)	2014-10-14	2022-01-11	诺华股份有限公司	针对pd-l1的抗体分子及其用途
US9724395B2 (en)	2014-10-21	2017-08-08	Sciclone Pharmaceuticals, Inc.	Treatment of cancer with immune stimulators
CA2965495C (en)	2014-10-23	2022-05-24	Regeneron Pharmaceuticals, Inc.	Cho integration sites and uses thereof
US20190194654A1 (en)	2014-10-24	2019-06-27	Astrazeneca Ab	Combination
GB201419084D0 (en)	2014-10-27	2014-12-10	Agency Science Tech & Res	Anti-PD-1 antibodies
US9765147B2 (en)	2014-10-29	2017-09-19	Five Prime Therapeutics, Inc.	Anti-CSFR1 antibody and anti PD-1 antibody combination therapy for cancer
AR102537A1 (es)	2014-11-05	2017-03-08	Flexus Biosciences Inc	Agentes inmunomoduladores
UY36390A (es)	2014-11-05	2016-06-01	Flexus Biosciences Inc	Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
EA201790806A1 (ru)	2014-11-05	2017-11-30	Флексус Байосайенсиз, Инк.	Иммунорегулирующие средства
CN107250157B (zh)	2014-11-21	2021-06-29	百时美施贵宝公司	包含修饰的重链恒定区的抗体
ME03806B (me)	2014-11-21	2021-04-20	Bristol Myers Squibb Co	Antitela protiv cd73 i njihova upotreba
KR20170088984A (ko)	2014-12-04	2017-08-02	브리스톨-마이어스 스큅 컴퍼니	암 (골수종)을 치료하기 위한 항-cs1 항체와 항-pd1 항체의 조합
TWI595006B (zh)	2014-12-09	2017-08-11	禮納特神經系統科學公司	抗ｐｄ－１抗體類和使用彼等之方法
TW201630907A (zh)	2014-12-22	2016-09-01	必治妥美雅史谷比公司	ＴＧＦβＲ拮抗劑
MX2017007744A (es)	2014-12-23	2017-09-05	Bristol Myers Squibb Co	Anticuerpos contra el inmunorreceptor de celulas t con dominios de inmunoglobulina y de porcion inhibidora con base en tirosina del inmumorreceptor (tigit).
US10983128B2 (en)	2015-02-05	2021-04-20	Bristol-Myers Squibb Company	CXCL11 and SMICA as predictive biomarkers for efficacy of anti-CTLA4 immunotherapy
MY186133A (en)	2015-03-02	2021-06-24	Rigel Pharmaceuticals Inc	Tgf-? inhibitors
AU2016229295B2 (en)	2015-03-06	2021-11-04	Beyondspring Pharmaceuticals, Inc.	Method of treating a brain tumor
BR112017018954A2 (pt)	2015-03-06	2018-05-15	Beyondspring Pharmaceuticals, Inc.	uso de forma mutante de proteína ras e método para tratar câncer
MA42971A (fr)	2015-03-13	2018-08-15	Cytomx Therapeutics Inc	Anticorps anti-pdl1, anticorps anti-pld1 activables, et leurs procédés d'utilisation
CA2981584A1 (en)	2015-04-03	2016-10-06	Bristol-Myers Squibb Company	Inhibitors of indoleamine 2,3-dioxygenase for the treatment of cancer
TW201642897A (zh)	2015-04-08	2016-12-16	Ｆ星生物科技有限公司	Ｈｅｒ２結合劑治療
GB201506411D0 (en)	2015-04-15	2015-05-27	Bergenbio As	Humanized anti-axl antibodies
EP3283107B1 (en)	2015-04-17	2020-05-27	Bristol-Myers Squibb Company	Compositions comprising a combination of ipilimumab and nivolumab
ES2861352T3 (es)	2015-04-28	2021-10-06	Bristol Myers Squibb Co	Tratamiento del melanoma positivo para PD-L1 utilizando un anticuerpo anti-PD-1
US10174113B2 (en)	2015-04-28	2019-01-08	Bristol-Myers Squibb Company	Treatment of PD-L1-negative melanoma using an anti-PD-1 antibody and an anti-CTLA-4 antibody
EP3294736B1 (en)	2015-05-11	2020-07-22	Bristol-Myers Squibb Company	Tricyclic compounds as anticancer agents
US9725449B2 (en)	2015-05-12	2017-08-08	Bristol-Myers Squibb Company	Tricyclic compounds as anticancer agents
ES2770349T3 (es)	2015-05-12	2020-07-01	Bristol Myers Squibb Co	Compuestos de 5H-pirido[3,2-b]indol como agentes antineoplásicos
JP6688551B2 (ja)	2015-05-21	2020-04-28	ハープーンセラピューティクス，インク．	三重特異性結合タンパク質と使用方法
WO2016191751A1 (en)	2015-05-28	2016-12-01	Bristol-Myers Squibb Company	Treatment of pd-l1 positive lung cancer using an anti-pd-1 antibody
US11078278B2 (en)	2015-05-29	2021-08-03	Bristol-Myers Squibb Company	Treatment of renal cell carcinoma
WO2016196237A1 (en)	2015-05-29	2016-12-08	Agenus Inc.	Anti-ctla-4 antibodies and methods of use thereof
SI3303396T1 (sl)	2015-05-29	2023-01-31	Bristol-Myers Squibb Company	Protitelesa proti OX40 in njihova uporaba
AU2016271101B2 (en)	2015-05-31	2021-04-01	Curegenix Corporation	Combination compositions for immunotherapy
TWI773646B (zh)	2015-06-08	2022-08-11	美商宏觀基因股份有限公司	結合lag-3的分子和其使用方法
US11078279B2 (en)	2015-06-12	2021-08-03	Macrogenics, Inc.	Combination therapy for the treatment of cancer
EP3307778A1 (en)	2015-06-12	2018-04-18	Bristol-Myers Squibb Company	Treatment of cancer by combined blockade of the pd-1 and cxcr4 signaling pathways
WO2016210223A1 (en)	2015-06-24	2016-12-29	Janssen Biotech, Inc.	Immune modulation and treatment of solid tumors with antibodies that specifically bind cd38
BR112017028353A2 (pt)	2015-06-29	2018-09-04	The Rockfeller University	anticorpos para cd40 com atividade agonista melhorada
MA42447A (fr)	2015-07-13	2018-05-23	Cytomx Therapeutics Inc	Anticorps anti-pd-1, anticorps anti-pd-1 activables, et leurs procédés d'utilisation
BR112018000229A2 (pt)	2015-07-13	2018-09-04	Beyondspring Pharmaceuticals Inc	composições de plinabulina
HUE053966T2 (hu)	2015-07-14	2021-08-30	Bristol Myers Squibb Co	Eljárás rák kezelésére immunellenõrzõpont inhibitorral, antitest, amely köt programozott halál-1 receptorhoz (PD-1) vagy programozott halál ligandum 1-hez (PD-L1)
EP3328861A1 (en)	2015-07-28	2018-06-06	Bristol-Myers Squibb Company	Tgf beta receptor antagonists
TWI762879B (zh)	2015-07-30	2022-05-01	美商宏觀基因股份有限公司	Pd-1結合分子和其使用方法
CA2994631A1 (en)	2015-08-07	2017-02-16	Pieris Pharmaceuticals Gmbh	Novel fusion polypeptide specific for lag-3 and pd-1
WO2017024465A1 (en)	2015-08-10	2017-02-16	Innovent Biologics (Suzhou) Co., Ltd.	Pd-1 antibodies
SG10201914109VA (en)	2015-08-11	2020-02-27	Wuxi Biologics Cayman Inc	Novel anti-pd-1 antibodies
CN106432494B9 (zh) *	2015-08-11	2022-02-15	广州誉衡生物科技有限公司	新型抗-pd-1抗体
AR105654A1 (es)	2015-08-24	2017-10-25	Lilly Co Eli	Anticuerpos pd-l1 (ligando 1 de muerte celular programada)
KR20180042370A (ko)	2015-08-25	2018-04-25	브리스톨-마이어스 스큅 컴퍼니	Tgf 베타 수용체 길항제
PE20181322A1 (es)	2015-09-01	2018-08-14	Agenus Inc	Anticuerpo anti-pd1 y sus metodos de uso
WO2017058859A1 (en)	2015-09-29	2017-04-06	Celgene Corporation	Pd-1 binding proteins and methods of use thereof
MA43053A (fr)	2015-09-30	2018-08-08	Janssen Biotech Inc	Anticorps antagonistes se liant spécifiquement au cd40 humain et procédés d'utilisation
MA43018B1 (fr)	2015-10-02	2021-11-30	Hoffmann La Roche	Anticorps anti-pd1 et procédés d'utilisation
LT3356411T (lt) *	2015-10-02	2021-09-10	F. Hoffmann-La Roche Ag	Bispecifiniai antikūnai, specifiniai pd1 ir tim3
GEP20217317B (en)	2015-10-08	2021-11-10	Macrogenics Inc	Combination therapy for the treatment of cancer
US11130817B2 (en)	2015-10-12	2021-09-28	Innate Pharma	CD73 blocking agents
ES2994611T3 (en)	2015-10-19	2025-01-27	Cg Oncology Inc	Methods of treating solid or lymphatic tumors by combination therapy
US10149887B2 (en)	2015-10-23	2018-12-11	Canbas Co., Ltd.	Peptides and peptidomimetics in combination with t cell activating and/or checkpoint inhibiting agents for cancer treatment
MA43163A (fr)	2015-11-02	2018-09-12	Five Prime Therapeutics Inc	Polypeptides à domaine extracellulaire cd80 et leur utilisation dans le traitement du cancer
LT3370768T (lt)	2015-11-03	2022-05-25	Janssen Biotech, Inc.	Antikūnai, specifiškai surišantys pd-1, ir jų panaudojimas
CA3003969A1 (en)	2015-11-06	2017-05-11	Orionis Biosciences Nv	Bi-functional chimeric proteins and uses thereof
RU2727914C2 (ru) *	2015-11-17	2020-07-24	Сучжоу Санкадия Биофармасьютикалз Ко., Лтд.	Антитело против лиганда 1 запрограммированной гибели клеток (pd-l1), его антигенсвязывающий фрагмент и их медицинское применение
TW202408573A (zh)	2015-11-18	2024-03-01	美商必治妥施貴寶公司	使用抗ｐｄ－１抗體與抗ｃｔｌａ－４抗體之組合以治療肺癌
CN106699889A (zh)	2015-11-18	2017-05-24	礼进生物医药科技（上海）有限公司	抗pd-1抗体及其治疗用途
KR20180082563A (ko)	2015-11-19	2018-07-18	브리스톨-마이어스 스큅 컴퍼니	글루코코르티코이드-유도된 종양 괴사 인자 수용체 (gitr)에 대한 항체 및 그의 용도
JP7349787B2 (ja)	2015-11-23	2023-09-25	ファイヴプライムセラピューティクスインク	癌治療におけるｆｇｆｒ２阻害剤単独または免疫刺激剤との組み合わせ
SG11201804309PA (en)	2015-11-25	2018-06-28	Visterra Inc	Antibody molecules to april and uses thereof
EA201891178A1 (ru)	2015-12-14	2019-01-31	Макродженикс, Инк.	Биспецифичные молекулы, обладающие иммунореактивностью в отношении pd-1 и ctla-4, и способы их применения
EP3390406A1 (en)	2015-12-15	2018-10-24	Bristol-Myers Squibb Company	Cxcr4 receptor antagonists
US10392442B2 (en)	2015-12-17	2019-08-27	Bristol-Myers Squibb Company	Use of anti-PD-1 antibody in combination with anti-CD27 antibody in cancer treatment
WO2017112775A1 (en)	2015-12-22	2017-06-29	Regeneron Pharmaceuticals, Inc.	Combination of anti-pd-1 antibodies and bispecific anti-cd20/anti-cd3 antibodies to treat cancer
CN106943598A (zh)	2016-01-07	2017-07-14	博笛生物科技（北京）有限公司	用于治疗肿瘤的抗-her2组合
CN106943597A (zh)	2016-01-07	2017-07-14	博笛生物科技（北京）有限公司	用于治疗肿瘤的抗-egfr组合
CN106943596A (zh)	2016-01-07	2017-07-14	博笛生物科技（北京）有限公司	用于治疗肿瘤的抗-cd20组合
US20190178888A1 (en)	2016-01-11	2019-06-13	Technion Research & Development Foundation Limited	Methods of determining prognosis of sepsis and treating same
EP3868787A1 (en)	2016-01-21	2021-08-25	Innate Pharma	Neutralization of inhibitory pathways in lymphocytes
US11214617B2 (en)	2016-01-22	2022-01-04	MabQuest SA	Immunological reagents
AU2017208819B2 (en)	2016-01-22	2023-10-19	MabQuest SA	PD1 specific antibodies
JP6991979B2 (ja)	2016-02-05	2022-03-04	オリオニスバイオサイエンシズビーブイ	Ｃｄ８結合物質
US10912748B2 (en)	2016-02-08	2021-02-09	Beyondspring Pharmaceuticals, Inc.	Compositions containing tucaresol or its analogs
US11180546B2 (en)	2016-02-17	2021-11-23	Novartis Ag	TGFbeta 2 antibodies
BR112018067368A2 (pt)	2016-03-04	2019-01-15	Bristol-Myers Squibb Company	terapia de combinação com anticorpos anti-cd73
CN108699158B (zh)	2016-03-08	2022-06-03	依奈特制药公司	Siglec中和抗体
CN108778301A (zh)	2016-03-10	2018-11-09	永恒生物科技股份有限公司	通过联合疗法来治疗实体瘤或淋巴瘤的方法
BR112018068461A2 (pt)	2016-03-15	2019-01-22	Mersana Therapeutics Inc	conjugado, composição farmacêutica, métodos para preparação de um conjugado e para alívio de um sintoma de um câncer.
TW201735949A (zh)	2016-03-24	2017-10-16	千禧製藥公司	治療抗ctla4及抗pd-1組合治療中的胃腸道免疫相關不良事件之方法
US11760803B2 (en)	2016-03-24	2023-09-19	Takeda Pharmaceutical Company Limited	Methods of treating gastrointestinal immune-related adverse events in immune oncology treatments
EP3436829A1 (en)	2016-03-30	2019-02-06	Centre Léon-Bérard	Lymphocytes expressing cd73 in cancerous patient dictates therapy
WO2017176925A1 (en)	2016-04-05	2017-10-12	Bristol-Myers Squibb Company	Cytokine profiling analysis for predicting prognosis of a patient in need of an anti-cancer treatment
CN116059351A (zh)	2016-04-18	2023-05-05	塞德斯医疗公司	结合人cd40的激动性抗体及其用途
WO2017192811A1 (en)	2016-05-04	2017-11-09	Bristol-Myers Squibb Company	Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
WO2017192844A1 (en)	2016-05-04	2017-11-09	Bristol-Myers Squibb Company	Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
JP2019516687A (ja)	2016-05-04	2019-06-20	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	インドールアミン２，３−ジオキシゲナーゼ阻害剤およびその使用方法
JP2019516681A (ja)	2016-05-04	2019-06-20	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	インドールアミン２，３−ジオキシゲナーゼ阻害剤およびその使用方法
KR20190003686A (ko)	2016-05-04	2019-01-09	브리스톨-마이어스 스큅 컴퍼니	인돌아민 2,3-디옥시게나제의 억제제 및 그의 사용 방법
AR108377A1 (es) *	2016-05-06	2018-08-15	Medimmune Llc	Proteínas de unión biespecíficas y sus usos
CA3023883A1 (en)	2016-05-13	2017-11-16	Orionis Biosciences Nv	Targeted mutant interferon-beta and uses thereof
EP3243832A1 (en)	2016-05-13	2017-11-15	F. Hoffmann-La Roche AG	Antigen binding molecules comprising a tnf family ligand trimer and pd1 binding moiety
TWI786044B (zh)	2016-05-13	2022-12-11	美商再生元醫藥公司	藉由投予ｐｄ-１抑制劑治療皮膚癌之方法
CN109563141A (zh)	2016-05-13	2019-04-02	奥里尼斯生物科学公司	对非细胞结构的治疗性靶向
US11623958B2 (en)	2016-05-20	2023-04-11	Harpoon Therapeutics, Inc.	Single chain variable fragment CD3 binding proteins
CN105968200B (zh) *	2016-05-20	2019-03-15	瑞阳(苏州)生物科技有限公司	抗人pd-l1人源化单克隆抗体及其应用
CN106008714B (zh)	2016-05-24	2019-03-15	瑞阳(苏州)生物科技有限公司	抗人pd-1人源化单克隆抗体及其应用
SG11201810023QA (en)	2016-05-27	2018-12-28	Agenus Inc	Anti-tim-3 antibodies and methods of use thereof
WO2017210335A1 (en)	2016-06-01	2017-12-07	Bristol-Myers Squibb Company	Imaging methods using 18f-radiolabeled biologics
CN109476752A (zh)	2016-06-02	2019-03-15	百时美施贵宝公司	抗-pd-1抗体与抗-cd30抗体的组合在淋巴瘤治疗中的用途
FI3463457T3 (fi)	2016-06-02	2023-09-12	Bristol Myers Squibb Co	Pd-1-esto nivolumabilla refraktaarinen hodgkinin lymfoomassa
EP3988570A1 (en)	2016-06-03	2022-04-27	Bristol-Myers Squibb Company	Use of anti-pd-1 antibody in the treatment of patients with colorectal cancer
KR20190015408A (ko)	2016-06-03	2019-02-13	브리스톨-마이어스 스큅 컴퍼니	종양을 치료하는 방법에 사용하기 위한 항-pd-1 항체
KR20190015407A (ko)	2016-06-03	2019-02-13	브리스톨-마이어스 스큅 컴퍼니	재발성 소세포 폐암의 치료 방법에 사용하기 위한 항-pd-1 항체
IL263439B1 (en)	2016-06-06	2025-02-01	Beyondspring Pharmaceuticals Inc	Composition and method for reducing neutropenia
JP7185530B2 (ja)	2016-06-13	2022-12-07	トルクセラピューティクス，インコーポレイテッド	免疫細胞機能を促進するための方法および組成物
US9567399B1 (en)	2016-06-20	2017-02-14	Kymab Limited	Antibodies and immunocytokines
WO2018029474A2 (en)	2016-08-09	2018-02-15	Kymab Limited	Anti-icos antibodies
EP3471754A1 (en)	2016-06-20	2019-04-24	Kymab Limited	Anti-pd-l1 antibodies
EP3478321A4 (en)	2016-06-30	2020-04-22	Oncorus, Inc.	PSEUDOTYPIZED ONCOLYTIC VIRAL ADMINISTRATION OF THERAPEUTIC POLYPEPTIDES
JP6993056B2 (ja)	2016-07-05	2022-02-15	ベイジーンリミテッド	癌治療のためのｐｄ－１アンタゴニスト及びｒａｆ阻害剤の組合せ
KR102726248B1 (ko)	2016-07-07	2024-11-05	더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티	항체-애쥬번트 접합체
KR102493282B1 (ko)	2016-07-14	2023-02-01	브리스톨-마이어스 스큅 컴퍼니	Tim3에 대한 항체 및 그의 용도
WO2018017633A1 (en)	2016-07-21	2018-01-25	Bristol-Myers Squibb Company	TGF Beta RECEPTOR ANTAGONISTS
KR102604433B1 (ko)	2016-08-09	2023-11-24	키맵 리미티드	항-icos 항체
ES2971881T3 (es)	2016-08-19	2024-06-10	Beigene Switzerland Gmbh	Combinación de zanubrutinib con un anticuerpo anti-cd20 o anti-pd-1 para su uso en el tratamiento del cáncer
WO2018035710A1 (en)	2016-08-23	2018-03-01	Akeso Biopharma, Inc.	Anti-ctla4 antibodies
CN106967172B (zh)	2016-08-23	2019-01-08	康方药业有限公司	抗ctla4-抗pd-1 双功能抗体、其药物组合物及其用途
CN106977602B (zh) *	2016-08-23	2018-09-25	中山康方生物医药有限公司	一种抗pd1单克隆抗体、其药物组合物及其用途
US11351164B2 (en)	2016-08-26	2022-06-07	Bristol-Myers Squibb Company	Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
US20190218294A1 (en)	2016-09-09	2019-07-18	Bristol-Myers Squibb Company	Use of an anti-pd-1 antibody in combination with an anti-mesothelin antibody in cancer treatment
MX2019002867A (es)	2016-09-19	2019-11-12	Celgene Corp	Metodos de tratamiento de trastornos inmunologicos usando proteinas de union a pd-1.
JP2019534859A (ja)	2016-09-19	2019-12-05	セルジーンコーポレイション	Ｐｄ−１結合タンパク質を使用して白斑を治療する方法
EP4360714A3 (en)	2016-09-21	2024-07-24	Nextcure, Inc.	Antibodies for siglec-15 and methods of use thereof
JP7069177B2 (ja)	2016-09-21	2022-05-17	ネクストキュアインコーポレイテッド	シグレック－１５に対する抗体及びその使用方法
EA201990285A1 (ru)	2016-09-29	2019-12-30	Бейджин Ханми Фармасьютикал Ко., Лтд.	Гетеродимерные иммуноглобулиновые конструкции и способы их получения
TWI843168B (zh)	2016-10-11	2024-05-21	美商艾吉納斯公司	抗ｌａｇ－３抗體及其使用方法
ES2917000T3 (es)	2016-10-24	2022-07-06	Orionis Biosciences BV	Interferón-gamma mutante diana y usos del mismo
KR102634093B1 (ko)	2016-10-28	2024-02-07	브리스톨-마이어스 스큅 컴퍼니	항-pd-1 항체를 사용하여 요로상피 암종을 치료하는 방법
UY37463A (es)	2016-11-02	2018-05-31	Glaxosmithkline Ip No 2 Ltd	Proteínas de unión
SG11201902857SA (en)	2016-11-03	2019-05-30	Bristol Myers Squibb Co	Activatable anti-ctla-4 antibodies and uses thereof
EP3534947A1 (en)	2016-11-03	2019-09-11	Kymab Limited	Antibodies, combinations comprising antibodies, biomarkers, uses & methods
US10660909B2 (en)	2016-11-17	2020-05-26	Syntrix Biosystems Inc.	Method for treating cancer using chemokine antagonists
SG10201913260VA (en)	2016-11-18	2020-03-30	Beijing Hanmi Pharmaceutical Co Ltd	Anti-pd-1/anti-her2 natural antibody structural heterodimeric bispecific antibody and method of preparing the same
WO2018094275A1 (en)	2016-11-18	2018-05-24	Tolero Pharmaceuticals, Inc.	Alvocidib prodrugs and their use as protein kinase inhibitors
WO2018098352A2 (en)	2016-11-22	2018-05-31	Jun Oishi	Targeting kras induced immune checkpoint expression
US11135307B2 (en)	2016-11-23	2021-10-05	Mersana Therapeutics, Inc.	Peptide-containing linkers for antibody-drug conjugates
TW201825119A (zh)	2016-11-30	2018-07-16	日商協和醱酵麒麟有限公司	使用抗ccr4抗體及抗pd-1抗體治療癌症之方法
PE20190921A1 (es)	2016-12-07	2019-06-26	Agenus Inc	Anticuerpos y metodos de su utilizacion
MA50949B1 (fr)	2016-12-07	2023-12-29	Memorial Sloan Kettering Cancer Center	Anticorps anti-ctla-4 et leurs procédés d'utilisation
WO2018112360A1 (en)	2016-12-16	2018-06-21	Evelo Biosciences, Inc.	Combination therapies for treating cancer
WO2018112364A1 (en)	2016-12-16	2018-06-21	Evelo Biosciences, Inc.	Combination therapies for treating melanoma
CN110337448B (zh) *	2016-12-23	2023-08-08	瑞美德生物医药科技有限公司	使用与程序性死亡配体1(pd-l1)结合的抗体的免疫疗法
CN108239083B (zh)	2016-12-26	2021-08-17	阿里根公司	芳香烃受体调节剂
KR102679324B1 (ko)	2017-01-05	2024-06-28	네트리 파르마	네트린-1 간섭 약물과 면역 관문 억제제 약물의 조합 치료
US10961239B2 (en)	2017-01-05	2021-03-30	Bristol-Myers Squibb Company	TGF beta receptor antagonists
EP3565812B1 (en)	2017-01-06	2023-12-27	Beyondspring Pharmaceuticals, Inc.	Tubulin binding compounds and therapeutic use thereof
EP3568412A2 (en)	2017-01-13	2019-11-20	Agenus Inc.	T cell receptors that bind to ny-eso-1 and methods of use thereof
WO2018134279A1 (en)	2017-01-18	2018-07-26	Pieris Pharmaceuticals Gmbh	Novel fusion polypeptides specific for lag-3 and pd-1
MX2019008348A (es) *	2017-01-18	2019-10-21	Genentech Inc	Anticuerpos idiotipo contra anticuerpos anti-pd-l1 y usos de estos solicitudes relacionadas.
WO2018134784A1 (en)	2017-01-20	2018-07-26	Novartis Ag	Combination therapy for the treatment of cancer
TWI787230B (zh)	2017-01-20	2022-12-21	法商賽諾菲公司	抗ＴＧＦ-β抗體及其用途
KR102611446B1 (ko)	2017-01-20	2023-12-06	아르커스 바이오사이언시즈 인코포레이티드	암-관련 장애의 치료를 위한 아졸로피리미딘
TW202421659A (zh)	2017-01-20	2024-06-01	美商健臻公司	骨靶向抗體
WO2018134681A1 (en)	2017-01-20	2018-07-26	Sanofi	Anti-tgf-beta antibodies and their use
WO2018137681A1 (en)	2017-01-25	2018-08-02	Beigene, Ltd.	Crystalline forms of (s) -7- (1- (but-2-ynoyl) piperidin-4-yl) -2- (4-phenoxyphenyl) -4, 5, 6, 7-tetrahy dropyrazolo [1, 5-a] pyrimidine-3-carboxamide, preparation, and uses thereof
CA3052190A1 (en)	2017-02-01	2018-08-09	Beyondspring Pharmaceuticals, Inc.	Method of reducing neutropenia
JP7476467B2 (ja)	2017-02-06	2024-05-01	オリオンズバイオサイエンスビーブイ	標的化キメラタンパク質及びその使用
CN110573172A (zh)	2017-02-06	2019-12-13	奥里尼斯生物科学有限公司	靶向的工程化干扰素及其用途
WO2018141959A1 (en)	2017-02-06	2018-08-09	Innate Pharma	Immunomodulatory antibody drug conjugates binding to a human mica polypeptide
HUE057337T2 (hu)	2017-02-10	2022-05-28	Novartis Ag	1-(4-amino-5-bróm-6-(1H-pirazol-1-il)pirimidin-2-il)-1H-pirazol-4-ol és alkalmazása rák kezelésében
TWI674261B (zh)	2017-02-17	2019-10-11	美商英能腫瘤免疫股份有限公司	Nlrp3 調節劑
IL268836B2 (en)	2017-02-24	2024-04-01	Macrogenics Inc	Bispecific binding molecules that are capable of binding cd137 and tumor antigens, and uses thereof
US20180271996A1 (en)	2017-02-28	2018-09-27	Mersana Therapeutics, Inc.	Combination therapies of her2-targeted antibody-drug conjugates
JP6949131B2 (ja)	2017-02-28	2021-10-13	サノフイＳａｎｏｆｉ	治療用ｒｎａ
KR102584011B1 (ko)	2017-03-16	2023-09-27	이나뜨 파르마 에스.에이.	암 치료를 위한 조성물 및 방법
SG10202110594UA (en)	2017-03-31	2021-11-29	Bristol Myers Squibb Co	Methods of treating tumor
EP3601353A1 (en)	2017-03-31	2020-02-05	Five Prime Therapeutics, Inc.	Combination therapy for cancer using anti-gitr antibodies
WO2018177324A1 (zh) *	2017-04-01	2018-10-04	北京韩美药品有限公司	抗pd‐l1/抗pd‐1天然抗体结构样异源二聚体形式双特异抗体及其制备
SG11201909205YA (en)	2017-04-03	2019-11-28	Hoffmann La Roche	Immunoconjugates of an anti-pd-1 antibody with a mutant il-2 or with il-15
MA49038B1 (fr)	2017-04-05	2025-01-31	F. Hoffmann-La Roche Ag	Anticorps bispécifiques se liant particulièrement à pd1 et lag3
US11603407B2 (en)	2017-04-06	2023-03-14	Regeneron Pharmaceuticals, Inc.	Stable antibody formulation
TWI788340B (zh)	2017-04-07	2023-01-01	美商必治妥美雅史谷比公司	抗icos促效劑抗體及其用途
CN110546166B (zh)	2017-04-13	2024-03-29	艾吉纳斯公司	抗cd137抗体和其使用方法
CN108728444A (zh)	2017-04-18	2018-11-02	长春华普生物技术股份有限公司	免疫调节性多核苷酸及其应用
US11596696B2 (en)	2017-04-20	2023-03-07	Adc Therapeutics Sa	Combination therapy with an anti-CD25 antibody-drug conjugate
US20200129637A1 (en)	2017-04-20	2020-04-30	Adc Therapeutics Sa	Combination therapy with an anti-axl antibody-drug conjugate
CN106939049B (zh) *	2017-04-20	2019-10-01	苏州思坦维生物技术股份有限公司	拮抗抑制人pd-1抗原与其配体结合的单克隆抗体及其制备方法与应用
EP3612030A4 (en)	2017-04-21	2021-04-28	Ikena Oncology, Inc.	AHR INDOLE INHIBITORS AND THEIR USES
JP2020517699A (ja)	2017-04-26	2020-06-18	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	ジスルフィド結合の還元を最小限にする抗体製造法
CN108794467A (zh)	2017-04-27	2018-11-13	博笛生物科技有限公司	2-氨基-喹啉衍生物
AR111651A1 (es)	2017-04-28	2019-08-07	Novartis Ag	Conjugados de anticuerpos que comprenden agonistas del receptor de tipo toll y terapias de combinación
US11021537B2 (en)	2017-05-01	2021-06-01	Agenus Inc.	Anti-TIGIT antibodies and methods of use thereof
WO2018209298A1 (en)	2017-05-12	2018-11-15	Harpoon Therapeutics, Inc.	Mesothelin binding proteins
US11066392B2 (en)	2017-05-12	2021-07-20	Bristol-Myers Squibb Company	Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
JP7274426B2 (ja)	2017-05-16	2023-05-16	ブリストル－マイヤーズスクイブカンパニー	抗ｇｉｔｒアゴニスト抗体での癌の処置
CN110636846B (zh)	2017-05-17	2023-05-16	艾库斯生物科学有限公司	用于治疗癌症相关疾病的喹唑啉吡唑衍生物
AR111760A1 (es)	2017-05-19	2019-08-14	Novartis Ag	Compuestos y composiciones para el tratamiento de tumores sólidos mediante administración intratumoral
WO2018218056A1 (en)	2017-05-25	2018-11-29	Birstol-Myers Squibb Company	Antibodies comprising modified heavy constant regions
CA3060989A1 (en)	2017-05-30	2018-12-06	Bristol-Myers Squibb Company	Compositions comprising a combination of an anti-lag-3 antibody, a pd-1 pathway inhibitor, and an immunotherapeutic agent
WO2018222722A2 (en)	2017-05-30	2018-12-06	Bristol-Myers Squibb Company	Compositions comprising an anti-lag-3 antibody or an anti-lag-3 antibody and an anti-pd-1 or anti-pd-l1 antibody
AU2018277824A1 (en)	2017-05-30	2019-10-17	Bristol-Myers Squibb Company	Treatment of LAG-3 positive tumors
JOP20190279A1 (ar)	2017-05-31	2019-11-28	Novartis Ag	الصور البلورية من 5-برومو -2، 6-داي (1h-بيرازول -1-يل) بيريميدين -4- أمين وأملاح جديدة
EP3630840A1 (en)	2017-06-01	2020-04-08	Bristol-Myers Squibb Company	Methods of treating a tumor using an anti-pd-1 antibody
JP2020522486A (ja)	2017-06-01	2020-07-30	サイトメックスセラピューティクスインコーポレイテッド	活性化可能抗ｐｄｌ１抗体、およびその使用方法
CN110997725B (zh)	2017-06-12	2024-08-09	蓝鳍生物医药公司	抗-il1rap抗体和抗体药物缀合物
UA127900C2 (uk)	2017-06-14	2024-02-07	Ейдісі Терапьютікс Са	Схема дозування для введення adc до cd19
WO2018229715A1 (en)	2017-06-16	2018-12-20	Novartis Ag	Compositions comprising anti-cd32b antibodies and methods of use thereof
GB201709808D0 (en)	2017-06-20	2017-08-02	Kymab Ltd	Antibodies
EP3642240A1 (en)	2017-06-22	2020-04-29	Novartis AG	Antibody molecules to cd73 and uses thereof
WO2018234879A1 (en)	2017-06-22	2018-12-27	Novartis Ag	USE OF IL-1β BINDING ANTIBODIES IN THE TREATMENT OF CANCER
WO2018235056A1 (en)	2017-06-22	2018-12-27	Novartis Ag	Il-1beta binding antibodies for use in treating cancer
MY204117A (en)	2017-06-22	2024-08-08	Novartis Ag	Antibody molecules to cd73 and uses thereof
CA3067268A1 (en)	2017-06-23	2018-12-27	Birdie Biopharmaceuticals, Inc.	Crystalline resiquimod monosulfate anhydrate and its preparation and uses
EP3645569A4 (en)	2017-06-26	2021-03-24	BeiGene, Ltd.	IMMUNOTHERAPY FOR LIVER CELL CARCINOMA
CA3066747A1 (en)	2017-06-27	2019-01-03	Novartis Ag	Dosage regimens for anti-tim-3 antibodies and uses thereof
US11560425B2 (en)	2017-06-27	2023-01-24	Neuracle Science Co., Ltd.	Use of anti-FAM19A5 antibodies for treating cancers
EP3421494A1 (en)	2017-06-29	2019-01-02	Sanofi	Use of isatuximab in combination with an anti-pd-1 antibody
JP2020526520A (ja)	2017-06-30	2020-08-31	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	Ｉｄｏ阻害剤の非晶質形体および結晶形体
EA202090005A1 (ru)	2017-07-06	2020-06-18	Мерус Н.В.	Антитела, модулирующие биологическую активность, проявляемую клеткой
KR102677225B1 (ko)	2017-07-10	2024-06-24	이나뜨 파르마 에스.에이.	Siglec-9 중화 항체
NZ761519A (en)	2017-07-14	2023-07-28	Innate Tumor Immunity Inc	Nlrp3 modulators
CN111163798A (zh)	2017-07-20	2020-05-15	诺华股份有限公司	用于抗lag-3抗体的给药方案及其用途
EP3655429A1 (en)	2017-07-21	2020-05-27	Novimmune S.A.	Generating multispecific antibody mixtures and methods of uses thereof
EP3658565B1 (en)	2017-07-28	2022-11-09	Bristol-Myers Squibb Company	Cyclic dinucleotides as anticancer agents
EP3658914A1 (en)	2017-07-28	2020-06-03	Bristol-Myers Squibb Company	Predictive peripheral blood biomarker for checkpoint inhibitors
ES2926195T3 (es)	2017-08-04	2022-10-24	Bicycletx Ltd	Ligandos peptídicos bicíclicos específicos de CD137
AR112405A1 (es)	2017-08-07	2019-10-23	Amgen Inc	Tratamiento de cáncer de mama triple negativo o cáncer colorrectal con metástasis hepáticas
US10696650B2 (en)	2017-08-17	2020-06-30	Ikena Oncology, Inc.	AHR inhibitors and uses thereof
CN119552248A (zh)	2017-08-25	2025-03-04	戊瑞治疗有限公司	B7-h4抗体及其使用方法
CN111094982A (zh)	2017-08-28	2020-05-01	百时美施贵宝公司	用于治疗和诊断癌症的tim-3拮抗剂
CN111032672B (zh)	2017-08-31	2024-09-13	百时美施贵宝公司	作为抗癌剂的环二核苷酸
US10953032B2 (en)	2017-08-31	2021-03-23	Bristol-Myers Squibb Company	Cyclic dinucleotides as anticancer agents
US10947263B2 (en)	2017-08-31	2021-03-16	Bristol-Myers Squibb Company	Cyclic dinucleotides as anticancer agents
CA3073055A1 (en)	2017-09-04	2019-03-07	Agenus Inc.	T cell receptors that bind to mixed lineage leukemia (mll)-specific phosphopeptides and methods of use thereof
CN118909118A (zh)	2017-09-07	2024-11-08	奥古斯塔大学研究所公司	程序性细胞死亡蛋白1抗体
WO2019055579A1 (en)	2017-09-12	2019-03-21	Tolero Pharmaceuticals, Inc.	TREATMENT REGIME FOR CANCERS THAT ARE INSENSITIVE TO BCL-2 INHIBITORS USING THE MCL-1 ALVOCIDIB INHIBITOR
WO2019060693A1 (en)	2017-09-22	2019-03-28	Kymera Therapeutics, Inc.	CRBN LIGANDS AND USES THEREOF
JP7366031B2 (ja)	2017-09-22	2023-10-20	カイメラセラピューティクス，インコーポレイテッド	タンパク質分解剤およびそれらの使用
CN111542539B (zh)	2017-10-06	2023-10-20	先天制药公司	通过cd39/cd73轴恢复t细胞活性
US11649212B2 (en)	2017-10-09	2023-05-16	Bristol-Myers Squibb Company	Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
WO2019074824A1 (en)	2017-10-09	2019-04-18	Bristol-Myers Squibb Company	INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS AND METHODS OF USE
WO2019074887A1 (en)	2017-10-10	2019-04-18	Bristol-Myers Squibb Company	CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS
EP3694552A1 (en)	2017-10-10	2020-08-19	Tilos Therapeutics, Inc.	Anti-lap antibodies and uses thereof
IL315737A (en)	2017-10-13	2024-11-01	Harpoon Therapeutics Inc	B-cell maturation antigen-binding proteins
EP3694884A1 (en)	2017-10-15	2020-08-19	Bristol-Myers Squibb Company	Methods of treating tumor
JP7254821B2 (ja)	2017-10-16	2023-04-10	ブリストル－マイヤーズスクイブカンパニー	抗がん剤としての環状ジヌクレオチド
EP3700933A1 (en)	2017-10-25	2020-09-02	Novartis AG	Antibodies targeting cd32b and methods of use thereof
BR112020008127A2 (pt)	2017-10-27	2020-10-13	Pfizer Inc.	anticorpos e conjugados de anticorpo-fármaco específicos para cd123 e seus usos
CN111542544A (zh)	2017-11-01	2020-08-14	百时美施贵宝公司	用于治疗癌症的免疫刺激性激动性抗体
CN117343193A (zh) *	2017-11-02	2024-01-05	西雅图免疫公司	双特异性抗体及其制备和使用方法
CA3077664A1 (en)	2017-11-06	2019-05-09	Genentech, Inc.	Diagnostic and therapeutic methods for cancer
WO2019090198A1 (en)	2017-11-06	2019-05-09	Bristol-Myers Squibb Company	Isofuranone compounds useful as hpk1 inhibitors
BR112020008316A2 (pt)	2017-11-06	2020-10-20	Bristol-Myers Squibb Company	métodos para o tratamento de um tumor
RU2020119578A (ru)	2017-11-16	2021-12-17	Новартис Аг	Комбинированные терапии
CN111587249A (zh)	2017-11-20	2020-08-25	阿里根公司	吲哚化合物及其用途
WO2019104289A1 (en)	2017-11-27	2019-05-31	Mersana Therapeutics, Inc.	Pyrrolobenzodiazepine antibody conjugates
CN111801334B (zh)	2017-11-29	2023-06-09	百济神州瑞士有限责任公司	使用包含btk抑制剂的组合治疗惰性或侵袭性b-细胞淋巴瘤
CN111727373A (zh)	2017-11-30	2020-09-29	诺华股份有限公司	靶向bcma的嵌合抗原受体及其用途
GB201721338D0 (en)	2017-12-19	2018-01-31	Kymab Ltd	Anti-icos Antibodies
WO2019122882A1 (en)	2017-12-19	2019-06-27	Kymab Limited	Bispecific antibody for icos and pd-l1
TW201929908A (zh)	2017-12-21	2019-08-01	美商梅爾莎納醫療公司	吡咯并苯并二氮呯抗體共軛物
IL315310A (en)	2017-12-26	2024-10-01	Kymera Therapeutics Inc	Irak degraders and uses thereof
JP7284759B2 (ja)	2017-12-27	2023-05-31	ブリストル－マイヤーズスクイブカンパニー	抗ｃｄ４０抗体およびその使用
CN115925943A (zh) *	2017-12-27	2023-04-07	信达生物制药(苏州)有限公司	抗pd-l1抗体及其用途
WO2019133847A1 (en)	2017-12-29	2019-07-04	Oncorus, Inc.	Oncolytic viral delivery of therapeutic polypeptides
US11324774B2 (en)	2018-01-05	2022-05-10	Augusta University Research Institute, Inc.	Compositions of oral alkaline salts and metabolic acid inducers and uses thereof
WO2019136112A1 (en)	2018-01-05	2019-07-11	Bristol-Myers Squibb Company	Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
TW201930591A (zh)	2018-01-08	2019-08-01	瑞士商諾華公司	用於與嵌合抗原受體療法併用之免疫增強rna
WO2019140387A1 (en)	2018-01-12	2019-07-18	Kymera Therapeutics, Inc.	Crbn ligands and uses thereof
SG11202005323SA (en)	2018-01-12	2020-07-29	Bristol Myers Squibb Co	Combination therapy with anti-il-8 antibodies and anti-pd-1 antibodies for treating cancer
WO2019140380A1 (en)	2018-01-12	2019-07-18	Kymera Therapeutics, Inc.	Protein degraders and uses thereof
US12129297B2 (en)	2018-01-12	2024-10-29	Bristol-Myers Squibb Company	Antibodies against TIM3 and uses thereof
KR20200109339A (ko)	2018-01-16	2020-09-22	브리스톨-마이어스 스큅 컴퍼니	Tim3에 대한 항체를 사용하여 암을 치료하는 방법
AU2019210332A1 (en)	2018-01-22	2020-09-10	Pascal Biosciences Inc.	Cannabinoids and derivatives for promoting immunogenicity of tumor and infected cells
WO2019144098A1 (en)	2018-01-22	2019-07-25	Bristol-Myers Squibb Company	Compositions and methods of treating cancer
US11786523B2 (en)	2018-01-24	2023-10-17	Beyondspring Pharmaceuticals, Inc.	Composition and method for reducing thrombocytopenia
US20200354424A1 (en)	2018-01-26	2020-11-12	Orionis Biosciences, Inc.	Xcr1 binding agents and uses thereof
IL301089A (en)	2018-01-29	2023-05-01	Vertex Pharma	Gcn2 inhibitors and uses thereof
IL312674A (en)	2018-01-29	2024-07-01	Merck Patent Gmbh	GCN2 inhibitors and uses thereof
US20210038659A1 (en)	2018-01-31	2021-02-11	Novartis Ag	Combination therapy using a chimeric antigen receptor
EP3746480A1 (en)	2018-01-31	2020-12-09	F. Hoffmann-La Roche AG	Bispecific antibodies comprising an antigen-binding site binding to lag3
MX2020008208A (es)	2018-02-05	2020-11-09	Orionis Biosciences Inc	Agentes de unión a fibroblastos y uso de estos.
WO2019153200A1 (zh)	2018-02-08	2019-08-15	北京韩美药品有限公司	抗pd-1/抗her2天然抗体结构样异源二聚体形式双特异抗体及其制备
WO2019157124A1 (en)	2018-02-08	2019-08-15	Bristol-Myers Squibb Company	Combination of a tetanus toxoid, anti-ox40 antibody and/or anti-pd-1 antibody to treat tumors
EP3752203A1 (en)	2018-02-13	2020-12-23	Novartis AG	Chimeric antigen receptor therapy in combination with il-15r and il15
US10519187B2 (en)	2018-02-13	2019-12-31	Bristol-Myers Squibb Company	Cyclic dinucleotides as anticancer agents
WO2019165315A1 (en)	2018-02-23	2019-08-29	Syntrix Biosystems Inc.	Method for treating cancer using chemokine antagonists alone or in combination
WO2019169229A1 (en)	2018-03-01	2019-09-06	Nextcure, Inc.	Klrg1 binding compositions and methods of use thereof
EA202091810A1 (ru)	2018-03-02	2021-01-29	Файв Прайм Терапьютикс, Инк.	Антитела к b7-h4 и способы их применения
CN111801341B (zh)	2018-03-08	2023-10-24	百时美施贵宝公司	作为抗癌剂的环二核苷酸
KR20200135421A (ko)	2018-03-21	2020-12-02	파이브 프라임 테라퓨틱스, 인크.	산성 pH에서 VISTA에 결합하는 항체
MX2020009861A (es)	2018-03-23	2020-10-08	Bristol Myers Squibb Co	Anticuerpos contra el complejo principal de histocompatibilidad relacionado con las cadenas a y b clase i (mica) y/o (micb) y sus usos.
EP3774911A1 (en)	2018-03-30	2021-02-17	Bristol-Myers Squibb Company	Methods of treating tumor
EP3774903A1 (en)	2018-04-04	2021-02-17	Bristol-Myers Squibb Company	Anti-cd27 antibodies and uses thereof
MX2020010604A (es)	2018-04-12	2020-10-20	Bristol Myers Squibb Co	Terapia de combinacion anticancer con anticuerpo antagonista del grupo de diferenciacion 73 (cd73) y anticuerpo antagonista del eje proteina de muerte programada 1 (pd-1)/ligando de muerte programada 1 (pd-l1).
US20210147547A1 (en)	2018-04-13	2021-05-20	Novartis Ag	Dosage Regimens For Anti-Pd-L1 Antibodies And Uses Thereof
CA3096546A1 (en)	2018-04-16	2019-10-24	Arrys Therapeutics, Inc.	Ep4 inhibitors and use thereof
SG11202010463TA (en)	2018-04-25	2020-11-27	Innate Tumor Immunity Inc	Nlrp3 modulators
JP2021522239A (ja)	2018-04-26	2021-08-30	アジェナスインコーポレイテッド	熱ショックタンパク質結合ペプチド組成物およびその使用方法
US12048745B2 (en)	2018-05-01	2024-07-30	Augusta University Research Institute, Inc.	Methods for detecting and reversing immune therapy resistance
US12037323B2 (en)	2018-05-03	2024-07-16	Bristol-Myers Squibb Company	Uracil derivatives as Mer-AXL inhibitors
KR20210006353A (ko)	2018-05-04	2021-01-18	톨리스	상피 세포 및 골수 세포 모두를 활성화시키는 tlr3 리간드
BR112020023846A2 (pt)	2018-05-23	2021-04-13	Adc Therapeutics Sa	Adjuvante molecular
UY38247A (es)	2018-05-30	2019-12-31	Novartis Ag	Anticuerpos frente a entpd2, terapias de combinación y métodos de uso de los anticuerpos y las terapias de combinación
EP3810109B1 (en)	2018-05-31	2024-08-07	Peloton Therapeutics, Inc.	Compounds and compositions for inhibiting cd73
US20210214459A1 (en)	2018-05-31	2021-07-15	Novartis Ag	Antibody molecules to cd73 and uses thereof
EP3802611A2 (en)	2018-06-01	2021-04-14	Novartis AG	Binding molecules against bcma and uses thereof
EP3802613A4 (en) *	2018-06-05	2022-03-09	Jiangsu Alphamab Biopharmaceuticals Co., Ltd.	DIMER AND ITS USE
EP3806848A2 (en)	2018-06-15	2021-04-21	Flagship Pioneering Innovations V, Inc.	Increasing immune activity through modulation of postcellular signaling factors
DK3807316T3 (da)	2018-06-18	2024-07-29	Innate Pharma	Sammensætninger og fremgangsmåder til behandling af cancer
US11180531B2 (en)	2018-06-22	2021-11-23	Bicycletx Limited	Bicyclic peptide ligands specific for Nectin-4
CN112585166A (zh)	2018-06-23	2021-03-30	豪夫迈·罗氏有限公司	用pd-1轴结合拮抗剂、铂剂和拓扑异构酶ii抑制剂治疗肺癌的方法
CA3104647A1 (en)	2018-06-27	2020-01-02	Bristol-Myers Squibb Company	Naphthyridinone compounds useful as t cell activators
PL3814348T3 (pl)	2018-06-27	2023-09-11	Bristol-Myers Squibb Company	Podstawione związki naftyrydynonu przydatne jako aktywatory komórek t
US11292792B2 (en)	2018-07-06	2022-04-05	Kymera Therapeutics, Inc.	Tricyclic CRBN ligands and uses thereof
EP3820904A2 (en)	2018-07-09	2021-05-19	Five Prime Therapeutics, Inc.	Antibodies binding to ilt4
AR116109A1 (es)	2018-07-10	2021-03-31	Novartis Ag	Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos
HRP20231295T1 (hr)	2018-07-10	2024-02-02	Novartis Ag	Derivati 3-(5-hidroksi-1-oksoizoindolin-2-il)piperidin-2,6-diona i njihova upotreba u liječenju bolesti ovisnih o cinkovom prstu 2 (ikzf2) obitelji ikaros
BR112021000303A2 (pt)	2018-07-11	2021-04-13	Five Prime Therapeutics, Inc.	Anticorpos que se ligam a vista em ph ácido
WO2020014583A1 (en)	2018-07-13	2020-01-16	Bristol-Myers Squibb Company	Ox-40 agonist, pd-1 pathway inhibitor and ctla-4 inhibitor combination for use in a mehtod of treating a cancer or a solid tumor
WO2020018680A1 (en)	2018-07-18	2020-01-23	Arcus Biosciences, Inc.	Solid forms of an azolopyrimidine compound
MX2021000558A (es)	2018-07-18	2021-04-13	Genentech Inc	Metodos para tratar el cancer de pulmon con un antagonista de fijacion al eje pd-1, un antimetabolito y un agente de platino.
EP3823673A4 (en)	2018-07-20	2022-05-11	Surface Oncology, Inc.	ANTI-CD112R COMPOSITIONS AND METHODS
US12059420B2 (en)	2018-07-23	2024-08-13	Bristol-Myers Squibb Company	Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
US12145927B2 (en)	2018-07-23	2024-11-19	Bristol-Myers Squibb Company	Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
WO2020021465A1 (en)	2018-07-25	2020-01-30	Advanced Accelerator Applications (Italy) S.R.L.	Method of treatment of neuroendocrine tumors
CN112739371A (zh)	2018-07-26	2021-04-30	百时美施贵宝公司	用于治疗癌症的lag-3组合疗法
WO2020021061A1 (en)	2018-07-26	2020-01-30	Pieris Pharmaceuticals Gmbh	Humanized anti-pd-1 antibodies and uses thereof
EP3837015B1 (en)	2018-08-16	2024-02-14	Innate Tumor Immunity, Inc.	Imidazo[4,5-c]quinoline derived nlrp3-modulators
WO2020037091A1 (en)	2018-08-16	2020-02-20	Innate Tumor Immunity, Inc.	Imidazo[4,5-c]quinoline derived nlrp3-modulators
US11572360B2 (en)	2018-08-16	2023-02-07	Innate Tumor Immunity, Inc.	Substituted 4-amino-1H-imidazo[4,5-c]quinoline compounds and improved methods for their preparation
TW202026423A (zh)	2018-08-24	2020-07-16	法商賽諾菲公司	用於實體瘤癌症的治療性ｒｎａ
WO2020043683A1 (en)	2018-08-27	2020-03-05	Pieris Pharmaceuticals Gmbh	Combination therapies comprising cd137/her2 bispecific agents and pd-1 axis inhibitors and uses thereof
US11253525B2 (en)	2018-08-29	2022-02-22	Bristol-Myers Squibb Company	Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
US10959986B2 (en)	2018-08-29	2021-03-30	Bristol-Myers Squibb Company	Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
WO2020044252A1 (en)	2018-08-31	2020-03-05	Novartis Ag	Dosage regimes for anti-m-csf antibodies and uses thereof
WO2020051099A1 (en)	2018-09-03	2020-03-12	Genentech, Inc.	Carboxamide and sulfonamide derivatives useful as tead modulators
WO2020049534A1 (en)	2018-09-07	2020-03-12	Novartis Ag	Sting agonist and combination therapy thereof for the treatment of cancer
CN113164419A (zh)	2018-09-07	2021-07-23	皮克医疗公司	Eif4e抑制剂和其用途
US20220177587A1 (en)	2018-09-19	2022-06-09	Alpine Immune Sciences, Inc.	Methods and uses of variant cd80 fusion proteins and related constructs
WO2020061482A1 (en)	2018-09-21	2020-03-26	Harpoon Therapeutics, Inc.	Egfr binding proteins and methods of use
CN113286817B (zh)	2018-09-25	2025-01-28	哈普恩治疗公司	Dll3结合蛋白及使用方法
CN112839962A (zh)	2018-10-09	2021-05-25	百时美施贵宝公司	用于治疗癌症的抗mertk抗体
TW202035445A (zh)	2018-10-10	2020-10-01	美商帝洛斯療法股份有限公司	抗lap抗體變異體及其用途
CN112867803A (zh)	2018-10-16	2021-05-28	诺华股份有限公司	单独的或与免疫标志物组合的肿瘤突变负荷作为生物标志物用于预测对靶向疗法的应答
MX2021003903A (es)	2018-10-19	2021-06-04	Bristol Myers Squibb Co	Terapia combinada para el melanoma.
KR20210081384A (ko)	2018-10-23	2021-07-01	브리스톨-마이어스 스큅 컴퍼니	종양을 치료하는 방법
EA202191175A1 (ru)	2018-10-29	2021-09-08	Мерсана Терапьютикс, Инк.	Сконструированные с цистеином конъюгаты антитело-лекарственное средство, содержащие пептидсодержащие линкеры
WO2020089811A1 (en)	2018-10-31	2020-05-07	Novartis Ag	Dc-sign antibody drug conjugates
TW202028222A (zh)	2018-11-14	2020-08-01	美商Ionis製藥公司	Foxp3表現之調節劑
US12226425B2 (en)	2018-11-16	2025-02-18	Arcus Biosciences, Inc.	Inhibitors of ARG1 and/or ARG2
US11274150B2 (en)	2018-11-16	2022-03-15	Bristol-Myers Squibb Company	Anti-human natural killer cell inhibitory receptor group 2A protein (NKG2A) antibodies
US20220008515A1 (en)	2018-11-16	2022-01-13	Neoimmunetech, Inc.	Method of treating a tumor with a combination of il-7 protein and an immune checkpoint inhibitor
US20230054194A1 (en)	2018-11-19	2023-02-23	Ariagen, Inc.	Methods of Treating Cancer
CN113348177A (zh)	2018-11-28	2021-09-03	百时美施贵宝公司	包含经修饰的重链恒定区的抗体
EP3886904A4 (en)	2018-11-30	2022-07-13	Kymera Therapeutics, Inc.	IRAQ-TYPE KINASE DEGRADING AGENTS AND THEIR USES
KR20210099066A (ko)	2018-12-04	2021-08-11	스미토모 다이니폰 파마 온콜로지, 인크.	암의 치료를 위한 작용제로서 사용하기 위한 cdk9 억제제 및 그의 다형체
KR20210098504A (ko)	2018-12-04	2021-08-10	브리스톨-마이어스 스큅 컴퍼니	다중 동위원소체 반응 모니터링에 의한 샘플내 보정 곡선을 사용한 분석 방법
EP3666905A1 (en)	2018-12-11	2020-06-17	Sanofi	E. coli positive for pks island as marker of positive response to anti-pd1 therapy in colorectal cancer
MX2021006831A (es)	2018-12-11	2021-07-02	Theravance Biopharma R&D Ip Llc	Inhibidores de alk5.
BR112021011874A2 (pt)	2018-12-20	2021-09-08	Novartis Ag	Regime de dosagem e combinação farmacêutica compreendendo derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona
EP3670659A1 (en)	2018-12-20	2020-06-24	Abivax	Biomarkers, and uses in treatment of viral infections, inflammations, or cancer
JP7450622B2 (ja)	2018-12-21	2024-03-15	ヴァレリオ・セラピューティクス	新規のコンジュゲートされた核酸分子及びその使用
WO2020128637A1 (en)	2018-12-21	2020-06-25	Novartis Ag	Use of il-1 binding antibodies in the treatment of a msi-h cancer
KR20210108422A (ko)	2018-12-21	2021-09-02	노파르티스 아게	IL-1β 결합 항체의 용도
WO2020128613A1 (en)	2018-12-21	2020-06-25	Novartis Ag	Use of il-1beta binding antibodies
MX2021007488A (es)	2018-12-21	2021-08-05	Novartis Ag	Uso de anticuerpos il-1 beta en el tratamiento o prevencion del sindrome mielodisplasico.
JP7340021B2 (ja)	2018-12-23	2023-09-06	エフ．ホフマン－ラロシュアーゲー	予測腫瘍遺伝子変異量に基づいた腫瘍分類
CN111423510B (zh)	2019-01-10	2024-02-06	迈威(上海)生物科技股份有限公司	重组抗人pd-1抗体及其应用
WO2020150114A1 (en)	2019-01-14	2020-07-23	Innate Tumor Immunity, Inc.	Heterocyclic nlrp3 modulators, for use in the treatment of cancer
JP7373571B2 (ja)	2019-01-14	2023-11-02	イネイト・テューマー・イミュニティ・インコーポレイテッド	がん治療に用いるためのｎｌｒｐ３モジュレーターとしての置換キナゾリン
US20220089572A1 (en)	2019-01-14	2022-03-24	Innate Tumor Immunity, Inc.	Nlrp3 modulators
CN113710702A (zh)	2019-01-14	2021-11-26	健泰科生物技术公司	用pd-1轴结合拮抗剂和rna疫苗治疗癌症的方法
JP7506080B2 (ja)	2019-01-14	2024-06-25	イネイト・テューマー・イミュニティ・インコーポレイテッド	Ｎｌｒｐ３モジュレーター
JP7636330B2 (ja)	2019-01-17	2025-02-26	ジョージアテックリサーチコーポレイション	酸化コレステロールを含有する薬物送達システム
KR20210118870A (ko)	2019-01-21	2021-10-01	사노피	진행성 단계의 고형 종양 암에 대한 치료용 rna 및 항-pd1 항체
KR20210146290A (ko)	2019-02-12	2021-12-03	스미토모 다이니폰 파마 온콜로지, 인크.	헤테로시클릭 단백질 키나제 억제제를 포함하는 제제
JP2022519385A (ja)	2019-02-12	2022-03-23	ノバルティスアーゲー	Ｔｎｏ１５５及びｐｄ－１阻害剤を含む医薬組合せ
EP3924054B1 (en)	2019-02-15	2025-04-02	Novartis AG	3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
CN113329792B (zh)	2019-02-15	2024-06-28	诺华股份有限公司	取代的3-(1-氧代异吲哚啉-2-基)哌啶-2,6-二酮衍生物及其用途
WO2020168244A1 (en)	2019-02-15	2020-08-20	Incelldx, Inc.	Assaying bladder-associated samples, identifying and treating bladder-associated neoplasia, and kits for use therein
US11279932B2 (en)	2019-02-27	2022-03-22	Ionis Pharmaceuticals, Inc.	Modulators of MALAT1 expression
AU2020241686A1 (en)	2019-03-15	2021-11-04	Bolt Biotherapeutics, Inc.	Immunoconjugates targeting HER2
SG11202109066RA (en)	2019-03-19	2021-09-29	Fundacio Privada Inst Dinvestigacio Oncològica De Vall Hebron	Combination therapy with omomyc and an antibody binding pd-1 or ctla-4 for the treatment of cancer
WO2020191326A1 (en)	2019-03-20	2020-09-24	Sumitomo Dainippon Pharma Oncology, Inc.	Treatment of acute myeloid leukemia (aml) with venetoclax failure
EP3941463A1 (en)	2019-03-22	2022-01-26	Sumitomo Dainippon Pharma Oncology, Inc.	Compositions comprising pkm2 modulators and methods of treatment using the same
WO2020198672A1 (en)	2019-03-28	2020-10-01	Bristol-Myers Squibb Company	Methods of treating tumor
KR20210146349A (ko)	2019-03-28	2021-12-03	브리스톨-마이어스 스큅 컴퍼니	종양을 치료하는 방법
KR20210144821A (ko)	2019-03-29	2021-11-30	아르커스 바이오사이언시즈 인코포레이티드	규명된 아데노신 지문을 이용한 암의 치료방법
WO2020201753A1 (en)	2019-04-02	2020-10-08	Bicycletx Limited	Bicycle toxin conjugates and uses thereof
KR20220006139A (ko)	2019-04-05	2022-01-14	카이메라 쎄라퓨틱스 인코포레이티드	Stat 분해제 및 이의 용도
EP3956327A1 (en)	2019-04-15	2022-02-23	Ariagen, Inc.	Chiral indole compounds and their use
EP3725370A1 (en)	2019-04-19	2020-10-21	ImmunoBrain Checkpoint, Inc.	Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease
AU2020258480A1 (en)	2019-04-19	2021-10-21	Genentech, Inc.	Anti-mertk antibodies and their methods of use
CN113784981B (zh)	2019-04-23	2025-01-28	先天制药公司	Cd73阻断抗体
WO2020226986A2 (en)	2019-05-03	2020-11-12	Genentech, Inc.	Methods of treating cancer with an anti-pd-l1 antibody
WO2020227159A2 (en)	2019-05-03	2020-11-12	Flagship Pioneering Innovations V, Inc.	Methods of modulating immune activity
WO2020232019A1 (en)	2019-05-13	2020-11-19	Regeneron Pharmaceuticals, Inc.	Combination of pd-1 inhibitors and lag-3 inhibitors for enhanced efficacy in treating cancer
WO2020231766A1 (en)	2019-05-13	2020-11-19	Bristol-Myers Squibb Company	AGONISTS OF ROR GAMMAt
WO2020231713A1 (en)	2019-05-13	2020-11-19	Bristol-Myers Squibb Company	AGONISTS OF ROR GAMMAt
JP2022534967A (ja)	2019-05-30	2022-08-04	ブリストル－マイヤーズスクイブカンパニー	多腫瘍遺伝子シグネチャーおよびその使用
EP3976832A1 (en)	2019-05-30	2022-04-06	Bristol-Myers Squibb Company	Methods of identifying a subject suitable for an immuno-oncology (i-o) therapy
US20220233691A1 (en)	2019-05-30	2022-07-28	Bristol-Myers Squibb Company	Cell localization signature and combination therapy
WO2020243423A1 (en)	2019-05-31	2020-12-03	Ikena Oncology, Inc.	Tead inhibitors and uses thereof
US11246906B2 (en)	2019-06-11	2022-02-15	Alkermes Pharma Ireland Limited	Compositions and methods for subcutaneous administration of cancer immunotherapy
CA3143634A1 (en)	2019-06-18	2020-12-24	Janssen Sciences Ireland Unlimited Company	Combination of hepatitis b virus (hbv) vaccines and anti-pd-1 antibody
EP3986454A1 (en)	2019-06-18	2022-04-27	Janssen Sciences Ireland Unlimited Company	Combination of hepatitis b virus (hbv) vaccines and anti-pd-1 or anti-pd-l1 antibody
KR20220028075A (ko)	2019-07-03	2022-03-08	스미토모 다이니폰 파마 온콜로지, 인크.	티로신 키나제 비-수용체 1 (tnk1) 억제제 및 그의 용도
WO2021026179A1 (en)	2019-08-06	2021-02-11	Bristol-Myers Squibb Company	AGONISTS OF ROR GAMMAt
WO2021024020A1 (en)	2019-08-06	2021-02-11	Astellas Pharma Inc.	Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer
TW202120550A (zh) *	2019-08-08	2021-06-01	日商小野藥品工業股份有限公司	雙特異性蛋白質
GB201912107D0 (en)	2019-08-22	2019-10-09	Amazentis Sa	Combination
AR119821A1 (es)	2019-08-28	2022-01-12	Bristol Myers Squibb Co	Compuestos de piridopirimidinonilo sustituidos útiles como activadores de células t
KR20220053007A (ko)	2019-08-30	2022-04-28	아게누스 인코포레이티드	항-cd96 항체 및 이의 사용 방법
CN114945366B (zh)	2019-09-13	2025-01-07	林伯士萨顿公司	Hpk1拮抗剂和其用途
WO2021055630A1 (en)	2019-09-17	2021-03-25	Bial- Biotech Investments, Inc.	Substituted, saturated and unsaturated n-heterocyclic carboxamides and related compounds for their use in the treatment of medical disorders
JP2022548747A (ja)	2019-09-17	2022-11-21	バイアル－アールアンドディーインベストメンツソシエダッドアノニマ	酸性セラミダーゼ阻害剤としての置換されたｎ－複素環式カルボキサミド及び医薬としてのその使用
AU2020349516A1 (en)	2019-09-17	2022-03-17	Bial-R&D Investments, S.A.	Substituted imidazole carboxamides and their use in the treatment of medical disorders
TW202124446A (zh)	2019-09-18	2021-07-01	瑞士商諾華公司	與ｅｎｔｐｄ２抗體之組合療法
JP2022548881A (ja)	2019-09-18	2022-11-22	ノバルティスアーゲー	Ｅｎｔｐｄ２抗体、組合せ療法並びに抗体及び組合せ療法を使用する方法
CA3149719A1 (en)	2019-09-19	2021-03-25	Bristol-Myers Squibb Company	Antibodies binding to vista at acidic ph
KR20220066334A (ko)	2019-09-22	2022-05-24	브리스톨-마이어스 스큅 컴퍼니	Lag-3 길항제 요법에 대한 정량적 공간 프로파일링
KR20220069964A (ko)	2019-09-25	2022-05-27	씨젠 인크.	조혈암의 치료를 위한 항-cd30 adc, 항-pd-1 및 화학치료제 조합
WO2021062018A1 (en)	2019-09-25	2021-04-01	Bristol-Myers Squibb Company	Composite biomarker for cancer therapy
US20220354880A1 (en)	2019-09-30	2022-11-10	Astrazeneca Ab	Combination treatment for cancer
AU2020358726A1 (en)	2019-10-01	2022-04-07	Silverback Therapeutics, Inc.	Combination therapy with immune stimulatory conjugates
CN114786680A (zh)	2019-10-21	2022-07-22	诺华股份有限公司	Tim-3抑制剂及其用途
CA3158298A1 (en)	2019-10-21	2021-04-29	Novartis Ag	Combination therapies with venetoclax and tim-3 inhibitors
BR112022008321A2 (pt)	2019-11-04	2022-07-26	Alector Llc	Polipeptídeos isolados, polipeptídeo, ácido nucleico isolado, vetor de expressão, célula hospedeira, métodos para produzir um polipeptídeo, para tratar câncer, para tratar uma doença neurológica ou neurodegenerativa, para repolarizar células supressoras, para repolarizar macrófagos de tumor e para ativar células mieloides em um sujeito e composições farmacêuticas
WO2021090146A1 (en)	2019-11-04	2021-05-14	Astrazeneca Ab	Combination therapy for treating cancer
CN115298549A (zh)	2019-11-05	2022-11-04	百时美施贵宝公司	M蛋白测定及其用途
WO2021092220A1 (en)	2019-11-06	2021-05-14	Bristol-Myers Squibb Company	Methods of identifying a subject with a tumor suitable for a checkpoint inhibitor therapy
WO2021092221A1 (en)	2019-11-06	2021-05-14	Bristol-Myers Squibb Company	Methods of identifying a subject with a tumor suitable for a checkpoint inhibitor therapy
US20220411499A1 (en)	2019-11-08	2022-12-29	Bristol-Myers Squibb Company	LAG-3 Antagonist Therapy for Melanoma
CR20220207A (es)	2019-11-13	2022-06-06	Genentech Inc	Compuestos terapéuticos y métodos de uso
EP4058465A1 (en)	2019-11-14	2022-09-21	Cohbar Inc.	Cxcr4 antagonist peptides
IL293027A (en)	2019-11-19	2022-07-01	Bristol Myers Squibb Co	Compounds useful as inhibitors of helios protein
AU2020385400A1 (en)	2019-11-22	2022-06-09	Theravance Biopharma R&D Ip, Llc	Substituted 1,5-naphthyridines or quinolines as ALK5 inhibitors
US20230000864A1 (en)	2019-11-22	2023-01-05	Sumitomo Pharma Oncology, Inc.	Solid dose pharmaceutical composition
IL293357A (en)	2019-11-26	2022-07-01	Bristol Myers Squibb Co	Salts/cocrystals of (r)-n-(4-chlorophenyl)-2-((1s,4s)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide
IL293326A (en)	2019-11-26	2022-07-01	Ikena Oncology Inc	Polymorphic carbazole derivatives and uses thereof
GB201917254D0 (en)	2019-11-27	2020-01-08	Adc Therapeutics Sa	Combination therapy
US11897950B2 (en)	2019-12-06	2024-02-13	Augusta University Research Institute, Inc.	Osteopontin monoclonal antibodies
CN115066259A (zh)	2019-12-09	2022-09-16	思进公司	使用liv1-adc和pd-1拮抗剂的组合疗法
US11591332B2 (en)	2019-12-17	2023-02-28	Kymera Therapeutics, Inc.	IRAK degraders and uses thereof
JP2023509366A (ja)	2019-12-17	2023-03-08	カイメラセラピューティクス，インコーポレイテッド	Ｉｒａｋ分解剤およびそれらの使用
WO2021127217A1 (en)	2019-12-17	2021-06-24	Flagship Pioneering Innovations V, Inc.	Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly
WO2021127554A1 (en)	2019-12-19	2021-06-24	Bristol-Myers Squibb Company	Combinations of dgk inhibitors and checkpoint antagonists
CA3165274A1 (en)	2019-12-20	2021-06-24	Novartis Ag	Combination of anti tim-3 antibody mbg453 and anti tgf-beta antibody nis793, with or without decitabine or the anti pd-1 antibody spartalizumab, for treating myelofibrosis and myelodysplastic syndrome
US20230118629A1 (en)	2019-12-23	2023-04-20	Bristol-Myers Squibb Company	Substituted piperazine derivatives useful as t cell activators
CN114846015B (zh)	2019-12-23	2024-07-30	百时美施贵宝公司	用作t细胞激活剂的经取代的杂芳基化合物
AR120823A1 (es)	2019-12-23	2022-03-23	Bristol Myers Squibb Co	Compuestos bicíclicos sustituidos útiles como activadores de células t
CA3162992A1 (en)	2019-12-23	2021-07-01	Louis S. Chupak	Substituted quinolinonyl piperazine compounds useful as t cell activators
CN115297931A (zh)	2019-12-23	2022-11-04	凯麦拉医疗公司	Smarca降解剂和其用途
CN114846007B (zh)	2019-12-23	2024-11-22	百时美施贵宝公司	可用作t细胞激活剂的经取代的喹唑啉基化合物
EP4087874A1 (en)	2020-01-06	2022-11-16	HiFiBiO (HK) Limited	Anti-tnfr2 antibody and uses thereof
IL294466A (en)	2020-01-07	2022-09-01	Hifibio Hk Ltd	Anti-galectin-9 antibody and uses thereof
CN115244052A (zh)	2020-01-10	2022-10-25	先天肿瘤免疫公司	Nlrp3调节剂
WO2021146370A1 (en)	2020-01-15	2021-07-22	Blueprint Medicines Corporation	Map4k1 inhibitors
CA3167413A1 (en)	2020-01-17	2021-07-22	Novartis Ag	Combination comprising a tim-3 inhibitor and a hypomethylating agent for use in treating myelodysplastic syndrome or chronic myelomonocytic leukemia
KR20220132598A (ko)	2020-01-28	2022-09-30	제넨테크, 인크.	암 치료를 위한 IL15/IL15R 알파 이종이량체 Fc-융합 단백질
CA3161513A1 (en)	2020-01-28	2021-08-05	Irwin DAVIDSON	Antisense oligonucleotide targeting linc00518 for treating melanoma
EP4097130A1 (en)	2020-01-30	2022-12-07	Ona Therapeutics S.L.	Combination therapy for treatment of cancer and cancer metastasis
EP4096708A1 (en)	2020-01-31	2022-12-07	Genentech, Inc.	Methods of inducing neoepitope-specific t cells with a pd-1 axis binding antagonist and an rna vaccine
JP2023514152A (ja)	2020-02-06	2023-04-05	ブリストル－マイヤーズスクイブカンパニー	Ｉｌ－１０およびその使用
US20230220074A1 (en)	2020-02-18	2023-07-13	Alector Llc	Pilra antibodies and methods of use thereof
JP2023516155A (ja)	2020-02-28	2023-04-18	ノバルティスアーゲー	ダブラフェニブ、ｅｒｋ阻害剤及びｒａｆ阻害剤又はｐｄ－１阻害剤を含む三重の医薬品の組合せ
BR112022017727A2 (pt)	2020-03-03	2022-11-16	Pic Therapeutics Inc	Inibidores de eif4e e usos dos mesmos
MX2022010936A (es)	2020-03-05	2022-11-16	Neotx Therapeutics Ltd	³métodos y composiciones para el tratamiento del cáncer con células inmunológicas.
BR112022016720A2 (pt)	2020-03-06	2022-11-16	Ona Therapeutics S L	Anticorpos anti-cd36 e seu uso para tratamento de câncer
IL296564A (en)	2020-03-06	2022-11-01	Celgene Quanticel Res Inc	Combination of an lsd-1 inhibitor and nivolumab for use in treating sclc or sqnsclc
WO2021183428A1 (en)	2020-03-09	2021-09-16	Bristol-Myers Squibb Company	Antibodies to cd40 with enhanced agonist activity
JP7474861B2 (ja)	2020-03-19	2024-04-25	アーカスバイオサイエンシーズ，インコーポレーテッド	Ｈｉｆ－２アルファの阻害剤としてのテトラリン化合物及びテトラヒドロキノリン化合物
KR20230005160A (ko)	2020-03-19	2023-01-09	카이메라 쎄라퓨틱스 인코포레이티드	Mdm2 분해제 및 이의 용도
PE20230821A1 (es)	2020-03-23	2023-05-19	Bristol Myers Squibb Co	Anticuerpos anti-ccr8 para el tratamiento del cancer
TW202140441A (zh)	2020-03-23	2021-11-01	美商必治妥美雅史谷比公司	經取代之側氧基異吲哚啉化合物
JP2023519346A (ja)	2020-03-27	2023-05-10	メンドゥス・ベスローテン・フェンノートシャップ	養子細胞療法の有効性を増強するための白血病由来の改変細胞のエクスビボ（ｅｘｖｉｖｏ）使用
EP4126824A1 (en)	2020-03-31	2023-02-08	Theravance Biopharma R&D IP, LLC	Substituted pyrimidines and methods of use
EP4132971A1 (en)	2020-04-09	2023-02-15	Merck Sharp & Dohme LLC	Affinity matured anti-lap antibodies and uses thereof
EP4138819A1 (en)	2020-04-21	2023-03-01	Novartis AG	Dosing regimen for treating a disease modulated by csf-1r
SE2050559A1 (en) *	2020-05-13	2021-11-14	Khs Biomedinvent Ab	PD-1 as a predictive marker for therapy in cancer
WO2021231732A1 (en)	2020-05-15	2021-11-18	Bristol-Myers Squibb Company	Antibodies to garp
AU2021284273A1 (en)	2020-06-02	2022-12-15	Arcus Biosciences, Inc.	Antibodies to TIGIT
TW202210483A (zh)	2020-06-03	2022-03-16	美商凱麥拉醫療公司	Irak降解劑之結晶型
US20230250110A1 (en)	2020-06-03	2023-08-10	Kymera Therapeutics, Inc.	Deuterated irak degraders and uses thereof
EP4165041A1 (en)	2020-06-10	2023-04-19	Theravance Biopharma R&D IP, LLC	Naphthyridine derivatives useful as alk5 inhibitors
KR20230024967A (ko)	2020-06-11	2023-02-21	노파르티스 아게	Zbtb32 억제제 및 이의 용도
TW202214857A (zh)	2020-06-19	2022-04-16	法商昂席歐公司	新型結合核酸分子及其用途
WO2021258010A1 (en)	2020-06-19	2021-12-23	Gossamer Bio Services, Inc.	Oxime compounds useful as t cell activators
KR20230027056A (ko)	2020-06-23	2023-02-27	노파르티스 아게	3-(1-옥소이소인돌린-2-일)피페리딘-2,6-디온 유도체를 포함하는 투약 요법
WO2022006179A1 (en)	2020-06-29	2022-01-06	Flagship Pioneering Innovations V, Inc.	Viruses engineered to promote thanotransmission and their use in treating cancer
KR20230033647A (ko)	2020-06-30	2023-03-08	멘두스 비.브이.	난소암 백신에서 백혈병 유래 세포의 용도
EP4178611A1 (en)	2020-07-07	2023-05-17	BioNTech SE	Therapeutic rna for hpv-positive cancer
WO2022009157A1 (en)	2020-07-10	2022-01-13	Novartis Ag	Lhc165 and spartalizumab combinations for treating solid tumors
US11787775B2 (en)	2020-07-24	2023-10-17	Genentech, Inc.	Therapeutic compounds and methods of use
IL300175A (en)	2020-07-30	2023-03-01	Kymera Therapeutics Inc	Methods of treating mutant lymphomas
EP4188549A1 (en)	2020-08-03	2023-06-07	Novartis AG	Heteroaryl substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
EP4192866A2 (en)	2020-08-10	2023-06-14	GV20 Therapeutics LLC	Compositions and methods for treating autoimmune diseases and cancers by targeting igsf8
JP2023537412A (ja)	2020-08-13	2023-08-31	ブリストル－マイヤーズスクイブカンパニー	目的の細胞を標的とするためのｉｌ－２の向け直し方法
CA3186504A1 (en)	2020-08-17	2022-02-24	Stephen J. Blakemore	Bicycle conjugates specific for nectin-4 and uses thereof
IL300328A (en)	2020-08-26	2023-04-01	Regeneron Pharma	Methods for treating cancer by administering a PD-1 inhibitor
EP4204095A1 (en)	2020-08-28	2023-07-05	Bristol-Myers Squibb Company	Lag-3 antagonist therapy for hepatocellular carcinoma
EP4204453A1 (en)	2020-08-31	2023-07-05	Bristol-Myers Squibb Company	Cell localization signature and immunotherapy
US20230321285A1 (en)	2020-08-31	2023-10-12	Advanced Accelerator Applications International Sa	Method of treating psma-expressing cancers
EP4204020A1 (en)	2020-08-31	2023-07-05	Advanced Accelerator Applications International S.A.	Method of treating psma-expressing cancers
KR20230080460A (ko)	2020-10-05	2023-06-07	브리스톨-마이어스 스큅 컴퍼니	단백질을 농축시키는 방법
US20230364127A1 (en)	2020-10-06	2023-11-16	Codiak Biosciences, Inc.	Extracellular vesicle-aso constructs targeting stat6
TW202233671A (zh)	2020-10-20	2022-09-01	美商建南德克公司	Ｐｅｇ結合抗ｍｅｒｔｋ抗體及其使用方法
US20240101666A1 (en)	2020-10-23	2024-03-28	Bristol-Myers Squibb Company	Lag-3 antagonist therapy for lung cancer
WO2022093981A1 (en)	2020-10-28	2022-05-05	Genentech, Inc.	Combination therapy comprising ptpn22 inhibitors and pd-l1 binding antagonists
EP4236960A1 (en)	2020-10-28	2023-09-06	Ikena Oncology, Inc.	Combination of an ahr inhibitor with a pdx inhibitor or doxorubicine
WO2022098628A2 (en)	2020-11-04	2022-05-12	Genentech, Inc.	Subcutaneous dosing of anti-cd20/anti-cd3 bispecific antibodies
EP4240492A2 (en)	2020-11-04	2023-09-13	Genentech, Inc.	Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies
WO2022098648A2 (en)	2020-11-04	2022-05-12	Genentech, Inc.	Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies and anti-cd79b antibody drug conjugates
WO2022097060A1 (en)	2020-11-06	2022-05-12	Novartis Ag	Cd19 binding molecules and uses thereof
JP2023549486A (ja)	2020-11-13	2023-11-27	ジェネンテック，インコーポレイテッド	肺がんを治療するためのｋｒａｓｇ１２ｃ阻害剤及びｐｄ－ｌ１結合アンタゴニストを含む方法及び組成物
WO2022120353A1 (en)	2020-12-02	2022-06-09	Ikena Oncology, Inc.	Tead inhibitors and uses thereof
KR20230131189A (ko)	2020-12-02	2023-09-12	이케나 온콜로지, 인코포레이티드	Tead 억제제 및 이의 용도
JP2023551906A (ja)	2020-12-02	2023-12-13	ジェネンテック，インコーポレイテッド	ネオアジュバントおよびアジュバント尿路上皮癌腫療法のための方法および組成物
WO2022120179A1 (en)	2020-12-03	2022-06-09	Bristol-Myers Squibb Company	Multi-tumor gene signatures and uses thereof
PH12023500013A1 (en)	2020-12-04	2024-03-11	Tidal Therapeutics Inc	Ionizable cationic lipids and lipi nanoparticles, and methods of synthesis and use thereof
TW202237119A (zh)	2020-12-10	2022-10-01	美商住友製藥腫瘤公司	Ａｌｋ﹘５抑制劑和彼之用途
CA3201893A1 (en)	2020-12-11	2022-06-16	The University Of North Carolina At Chapel Hill	Compositions and methods comprising sfrp2 antagonists
CN116964050A (zh)	2020-12-16	2023-10-27	戈萨默生物服务公司	可用作t细胞激活剂的化合物
WO2022135666A1 (en)	2020-12-21	2022-06-30	BioNTech SE	Treatment schedule for cytokine proteins
TW202245808A (zh)	2020-12-21	2022-12-01	德商拜恩迪克公司	用於治療癌症之治療性ｒｎａ
WO2022135667A1 (en)	2020-12-21	2022-06-30	BioNTech SE	Therapeutic rna for treating cancer
CA3196999A1 (en)	2020-12-28	2022-07-07	Masano HUANG	Methods of treating tumors
IL303648A (en)	2020-12-28	2023-08-01	Bristol Myers Squibb Co	Antibody compositions and methods of use thereof
PH12023500015A1 (en)	2020-12-30	2024-03-11	Kymera Therapeutics Inc	Irak degraders and uses thereof
CA3204392A1 (en)	2021-01-08	2022-07-14	Bristol-Myers Squibb Company	Combination therapy using an anti-fucosyl-gm1 antibody
US20240325554A1 (en)	2021-01-11	2024-10-03	Bicycle TX Limited	Methods for treating cancer
US20220249639A1 (en)	2021-01-22	2022-08-11	Dcprime B.V.	Methods of tumor vaccination
EP4284510A1 (en)	2021-01-29	2023-12-06	Novartis AG	Dosage regimes for anti-cd73 and anti-entpd2 antibodies and uses thereof
US20240307437A1 (en)	2021-01-29	2024-09-19	Iovance Biotherapeutics, Inc.	Cytokine associated tumor infiltrating lymphocytes compositions and methods
BR112023015590A2 (pt)	2021-02-02	2023-10-17	Liminal Biosciences Ltd	Antagonistas de gpr84 e usos dos mesmos
CA3206499A1 (en)	2021-02-02	2022-08-11	Liminal Biosciences Limited	Gpr84 antagonists and uses thereof
WO2022169921A1 (en)	2021-02-04	2022-08-11	Bristol-Myers Squibb Company	Benzofuran compounds as sting agonists
EP4291235A4 (en)	2021-02-12	2025-01-08	Nimbus Saturn Inc	HPK1 ANTAGONISTS AND THEIR USES
KR20230146052A (ko)	2021-02-12	2023-10-18	에프. 호프만-라 로슈 아게	암 치료용 비시클릭 테트라히드로아제핀 유도체
CN116867494A (zh)	2021-02-15	2023-10-10	凯麦拉医疗公司	Irak4降解剂和其用途
US12171768B2 (en)	2021-02-15	2024-12-24	Kymera Therapeutics, Inc.	IRAK4 degraders and uses thereof
GB202102396D0 (en)	2021-02-19	2021-04-07	Adc Therapeutics Sa	Molecular adjuvant
EP4301756A4 (en)	2021-03-05	2025-02-26	Nimbus Saturn Inc	HPK1 ANTAGONISTS AND THEIR USES
JP2024510176A (ja)	2021-03-08	2024-03-06	ブループリントメディシンズコーポレイション	Ｍａｐ４ｋ１阻害剤
US20220305100A1 (en)	2021-03-12	2022-09-29	Dcprime B.V.	Methods of vaccination and use of cd47 blockade
US11918582B2 (en)	2021-03-15	2024-03-05	Rapt Therapeutics, Inc.	Pyrazole pyrimidine compounds and uses thereof
CN117321418A (zh)	2021-03-18	2023-12-29	诺华股份有限公司	癌症生物标志物及其使用方法
KR20230159590A (ko)	2021-03-23	2023-11-21	리제너론 파아마슈티컬스, 인크.	Pd-1 억제제를 투여함에 의한 면역억제 또는 면역손상된 환자에서 암을 치료하는 방법
TW202304506A (zh)	2021-03-25	2023-02-01	日商安斯泰來製藥公司	涉及抗claudin 18.2抗體的組合治療以治療癌症
WO2022213062A1 (en)	2021-03-29	2022-10-06	Nimbus Saturn, Inc.	Hpk1 antagonists and uses thereof
JP2024514245A (ja)	2021-03-29	2024-03-29	ジュノーセラピューティクスインコーポレイテッド	チェックポイント阻害剤療法とｃａｒｔ細胞療法との組合せを用いた投薬および処置のための方法
KR20230163503A (ko)	2021-03-31	2023-11-30	메뤼스 엔.페.	신규한 pd-1 결합 도메인
CA3214085A1 (en)	2021-03-31	2022-10-06	Darby Rye Schmidt	Thanotransmission polypeptides and their use in treating cancer
EP4314068A1 (en)	2021-04-02	2024-02-07	The Regents Of The University Of California	Antibodies against cleaved cdcp1 and uses thereof
EP4320125A1 (en)	2021-04-05	2024-02-14	Bristol-Myers Squibb Company	Pyridinyl substituted oxoisoindoline compounds for the treatment of cancer
WO2022216644A1 (en)	2021-04-06	2022-10-13	Bristol-Myers Squibb Company	Pyridinyl substituted oxoisoindoline compounds
TW202304979A (zh)	2021-04-07	2023-02-01	瑞士商諾華公司	抗ＴＧＦβ抗體及其他治療劑用於治療增殖性疾病之用途
AU2022257621A1 (en)	2021-04-13	2023-11-23	Nuvalent, Inc.	Amino-substituted heterocycles for treating cancers with egfr mutations
CA3215081A1 (en)	2021-04-16	2022-10-20	Alfredo C. Castro	Mek inhibitors and uses thereof
JP2024516230A (ja)	2021-04-30	2024-04-12	ジェネンテック，インコーポレイテッド	がんのための治療及び診断方法並びに組成物
TW202243689A (zh)	2021-04-30	2022-11-16	瑞士商赫孚孟拉羅股份公司	抗ｃｄ２０／抗ｃｄ３雙特異性抗體及抗ｃｄ７８ｂ抗體藥物結合物的組合治療之給藥
CN117715904A (zh)	2021-05-07	2024-03-15	凯麦拉医疗公司	Cdk2降解剂和其用途
AR125874A1 (es)	2021-05-18	2023-08-23	Novartis Ag	Terapias de combinación
TW202313682A (zh)	2021-05-18	2023-04-01	英商凱麥博有限公司	抗icos抗體之用途
CN117337288A (zh)	2021-05-21	2024-01-02	艾库斯生物科学有限公司	Axl抑制剂化合物
US20240246967A1 (en)	2021-05-21	2024-07-25	Arcus Biosciences, Inc.	Axl compounds
WO2022251359A1 (en)	2021-05-26	2022-12-01	Theravance Biopharma R&D Ip, Llc	Bicyclic inhibitors of alk5 and methods of use
GB202107994D0 (en)	2021-06-04	2021-07-21	Kymab Ltd	Treatment of cancer
EP4355363A1 (en)	2021-06-18	2024-04-24	Genzyme Corporation	Anti-tgf-beta antibody formulations and their use
JP2024525475A (ja)	2021-06-29	2024-07-12	フラグシップパイオニアリングイノベーションズブイ，インコーポレーテッド	タノトランスミッションを促進するように操作された免疫細胞及びその使用
WO2023279092A2 (en)	2021-07-02	2023-01-05	Genentech, Inc.	Methods and compositions for treating cancer
MX2024000674A (es)	2021-07-13	2024-02-07	BioNTech SE	Agentes de union multiespecificos contra cd40 y cd137 en terapia de combinacion.
IL310025A (en)	2021-07-14	2024-03-01	Blueprint Medicines Corp	Heterocyclic compounds as MAP4K1 inhibitors
WO2023288264A1 (en)	2021-07-15	2023-01-19	Blueprint Medicines Corporation	Map4k1 inhibitors
EP4377350A2 (en)	2021-07-28	2024-06-05	Genentech, Inc.	Methods and compositions for treating cancer
CN117715936A (zh)	2021-07-28	2024-03-15	豪夫迈·罗氏有限公司	用于治疗癌症的方法和组合物
KR20240042476A (ko)	2021-07-30	2024-04-02	오엔에이 테라퓨틱스 에스.엘.	항-cd36 항체 및 암을 치료하기 위한 이의 용도
JP2024528217A (ja)	2021-08-03	2024-07-26	エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト	二重特異性抗体および使用方法
EP4380596A1 (en)	2021-08-04	2024-06-12	Genentech, Inc.	Il15/il15r alpha heterodimeric fc-fusion proteins for the expansion of nk cells in the treatment of solid tumours
WO2023020315A1 (zh) *	2021-08-19	2023-02-23	南京吉盛澳玛生物医药有限公司	靶向pd-l1/pd-1的抗体及其应用
IL310662A (en)	2021-08-23	2024-04-01	Immunitas Therapeutics Inc	Anti-CD161 antibodies and their uses
JP2024532276A (ja)	2021-08-25	2024-09-05	ピクセラピューティクス，インコーポレイテッド	ｅＩＦ４Ｅ阻害剤及びその使用
EP4392422A1 (en)	2021-08-25	2024-07-03	PIC Therapeutics, Inc.	Eif4e inhibitors and uses thereof
WO2023051926A1 (en)	2021-09-30	2023-04-06	BioNTech SE	Treatment involving non-immunogenic rna for antigen vaccination and pd-1 axis binding antagonists
WO2023056403A1 (en)	2021-09-30	2023-04-06	Genentech, Inc.	Methods for treatment of hematologic cancers using anti-tigit antibodies, anti-cd38 antibodies, and pd-1 axis binding antagonists
EP4413040A1 (en)	2021-10-06	2024-08-14	Genmab A/S	Multispecific binding agents against pd-l1 and cd137 in combination
TW202333802A (zh)	2021-10-11	2023-09-01	德商拜恩迪克公司	用於肺癌之治療性rna(二)
KR20240099331A (ko)	2021-10-28	2024-06-28	라이엘 이뮤노파마, 인크.	면역 세포를 배양하기 위한 방법
TW202334165A (zh)	2021-10-29	2023-09-01	美商凱麥拉醫療公司	Irak4降解劑及其製備
KR20240110814A (ko)	2021-10-29	2024-07-16	아르커스 바이오사이언시즈 인코포레이티드	Hif-2알파의 저해제 및 이의 사용 방법
WO2023077090A1 (en)	2021-10-29	2023-05-04	Bristol-Myers Squibb Company	Lag-3 antagonist therapy for hematological cancer
WO2023080900A1 (en)	2021-11-05	2023-05-11	Genentech, Inc.	Methods and compositions for classifying and treating kidney cancer
WO2023083439A1 (en)	2021-11-09	2023-05-19	BioNTech SE	Tlr7 agonist and combinations for cancer treatment
CA3240096A1 (en)	2021-11-12	2023-05-19	Novartis Ag	Combination therapy for treating lung cancer
TW202332429A (zh)	2021-11-24	2023-08-16	美商建南德克公司	治療性化合物及其使用方法
TW202340212A (zh)	2021-11-24	2023-10-16	美商建南德克公司	治療性化合物及其使用方法
CN118660964A (zh)	2021-12-16	2024-09-17	瓦莱里奥治疗公司	新型缀合核酸分子及其用途
WO2023114984A1 (en)	2021-12-17	2023-06-22	Ikena Oncology, Inc.	Tead inhibitors and uses thereof
WO2023122772A1 (en)	2021-12-22	2023-06-29	Gossamer Bio Services, Inc.	Oxime derivatives useful as t cell activators
WO2023122777A1 (en)	2021-12-22	2023-06-29	Gossamer Bio Services, Inc.	Oxime derivatives useful as t cell activators
WO2023122778A1 (en)	2021-12-22	2023-06-29	Gossamer Bio Services, Inc.	Pyridazinone derivatives useful as t cell activators
WO2023137161A1 (en)	2022-01-14	2023-07-20	Amgen Inc.	Triple blockade of tigit, cd112r, and pd-l1
EP4469477A1 (en)	2022-01-26	2024-12-04	Bristol-Myers Squibb Company	Combination therapy for hepatocellular carcinoma
WO2023147488A1 (en)	2022-01-28	2023-08-03	Iovance Biotherapeutics, Inc.	Cytokine associated tumor infiltrating lymphocytes compositions and methods
CN118984837A (zh)	2022-01-28	2024-11-19	乔治穆内公司	作为pd-1激动剂的程序性细胞死亡蛋白1的抗体
JP2025504059A (ja)	2022-01-31	2025-02-06	カイメラセラピューティクス，インコーポレイテッド	Ｉｒａｋデグレーダー及びその使用
CN118946556A (zh)	2022-02-01	2024-11-12	阿维纳斯运营公司	Dgk靶向化合物及其用途
AU2023221738A1 (en)	2022-02-17	2024-08-29	Regeneron Pharmaceuticals, Inc.	Combinations of checkpoint inhibitors and oncolytic virus for treating cancer
EP4482947A1 (en)	2022-02-24	2025-01-01	Amazentis SA	Uses of urolithins
AU2023226078A1 (en)	2022-02-25	2024-08-22	Bristol-Myers Squibb Company	Combination therapy for colorectal carcinoma.
WO2023168404A1 (en)	2022-03-04	2023-09-07	Bristol-Myers Squibb Company	Methods of treating a tumor
WO2023170606A1 (en)	2022-03-08	2023-09-14	Alentis Therapeutics Ag	Use of anti-claudin-1 antibodies to increase t cell availability
WO2023173057A1 (en)	2022-03-10	2023-09-14	Ikena Oncology, Inc.	Mek inhibitors and uses thereof
WO2023173053A1 (en)	2022-03-10	2023-09-14	Ikena Oncology, Inc.	Mek inhibitors and uses thereof
CN119013022A (zh)	2022-03-14	2024-11-22	来凯有限公司	癌症的组合治疗
WO2023178329A1 (en)	2022-03-18	2023-09-21	Bristol-Myers Squibb Company	Methods of isolating polypeptides
WO2023192478A1 (en)	2022-04-01	2023-10-05	Bristol-Myers Squibb Company	Combination therapy with anti-il-8 antibodies and anti-pd-1 antibodies for treating cancer
CN119487067A (zh)	2022-04-01	2025-02-18	基因泰克公司	用抗fcrh5/抗cd3双特异性抗体进行治疗的给药
WO2023196987A1 (en)	2022-04-07	2023-10-12	Bristol-Myers Squibb Company	Methods of treating tumor
EP4487226A1 (en)	2022-04-08	2025-01-08	Bristol-Myers Squibb Company	Machine learning identification, classification, and quantification of tertiary lymphoid structures
WO2023211889A1 (en)	2022-04-25	2023-11-02	Ikena Oncology, Inc.	Polymorphic compounds and uses thereof
EP4518895A1 (en)	2022-05-02	2025-03-12	Arcus Biosciences, Inc.	Anti-tigit antibodies and uses of the same
WO2023214325A1 (en)	2022-05-05	2023-11-09	Novartis Ag	Pyrazolopyrimidine derivatives and uses thereof as tet2 inhibitors
EP4522653A1 (en)	2022-05-11	2025-03-19	Genentech, Inc.	Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
EP4522657A1 (en)	2022-05-12	2025-03-19	Genmab A/S	Binding agents capable of binding to cd27 in combination therapy
TW202408523A (zh)	2022-05-12	2024-03-01	美商建南德克公司	包含ｓｈｐ２抑制劑及ｐｄ－ｌ１結合拮抗劑之方法及組成物
WO2023222854A1 (en)	2022-05-18	2023-11-23	Kymab Limited	Uses of anti-icos antibodies
IL316768A (en)	2022-05-25	2025-01-01	Ikena Oncology Inc	MEK inhibitors and their uses
IL317319A (en)	2022-06-02	2025-01-01	Bristol Myers Squibb Co	Antibody compounds and methods of using them
IL317449A (en)	2022-06-07	2025-02-01	Genentech Inc	Method for determining the efficacy of a lung cancer treatment comprising an anti-PD-L1 antagonist and an anti-TIGIT antibody-antagonist
TW202423482A (zh)	2022-06-08	2024-06-16	美商泰德治療公司	可電離陽離子脂質和脂質奈米顆粒、及其合成方法和用途
TW202417042A (zh)	2022-07-13	2024-05-01	美商建南德克公司	用抗ｆｃｒｈ５／抗ｃｄ３雙特異性抗體進行治療之給藥
US20240124490A1 (en)	2022-07-15	2024-04-18	Arcus Biosciences, Inc.	Inhibitors of hpk1 and methods of use thereof
CN119604530A (zh)	2022-07-19	2025-03-11	基因泰克公司	用抗fcrh5/抗cd3双特异性抗体进行治疗的给药
WO2024020034A1 (en)	2022-07-20	2024-01-25	Arcus Biosciences, Inc.	Cbl-b inhibitors and methods of use thereof
EP4310197A1 (en)	2022-07-21	2024-01-24	Fundación para la Investigación Biomédica del Hospital Universitario Puerta de Hierro Majadahonda	Method for identifying lung cancer patients for a combination treatment of immuno- and chemotherapy
AU2023313118A1 (en)	2022-07-27	2025-03-06	Astrazeneca Ab	Combinations of recombinant virus expressing interleukin-12 with pd-1/pd-l1 inhibitors
WO2024028364A1 (en)	2022-08-02	2024-02-08	Liminal Biosciences Limited	Aryl-triazolyl and related gpr84 antagonists and uses thereof
TW202416972A (zh)	2022-08-02	2024-05-01	英商利米那生物科技有限公司	經取代之吡啶酮gpr84拮抗劑及其用途
AU2023317740A1 (en)	2022-08-02	2025-03-13	Liminal Biosciences Limited	Heteroaryl carboxamide and related gpr84 antagonists and uses thereof
CN119654312A (zh)	2022-08-08	2025-03-18	百时美施贵宝公司	用作t细胞活化剂的取代的四唑基化合物
CN119677740A (zh)	2022-08-09	2025-03-21	百时美施贵宝公司	用作t细胞活化剂的叔胺取代的双环化合物
TW202417439A (zh)	2022-08-11	2024-05-01	瑞士商赫孚孟拉羅股份公司	雙環四氫噻吖呯衍生物
AR130167A1 (es)	2022-08-11	2024-11-13	Hoffmann La Roche	Derivados bicíclicos de tetrahidroazepina
CN119698413A (zh)	2022-08-11	2025-03-25	豪夫迈·罗氏有限公司	双环四氢硫氮杂䓬衍生物
IL316935A (en)	2022-08-11	2025-01-01	Hoffmann La Roche	TETRAHYDROTHIAZEPINE DERIVATIVES CYCLES
WO2024040175A1 (en)	2022-08-18	2024-02-22	Pulmatrix Operating Company, Inc.	Methods for treating cancer using inhaled angiogenesis inhibitor
WO2024049949A1 (en)	2022-09-01	2024-03-07	Genentech, Inc.	Therapeutic and diagnostic methods for bladder cancer
WO2024059142A1 (en)	2022-09-14	2024-03-21	Arcus Biosciences, Inc.	Dispersions of etrumadenant
WO2024069009A1 (en)	2022-09-30	2024-04-04	Alentis Therapeutics Ag	Treatment of drug-resistant hepatocellular carcinoma
WO2024073111A2 (en) *	2022-09-30	2024-04-04	Adicet Therapeutics, Inc.	Affinity binding entities directed to b7h6 and methods of use thereof
WO2024077166A1 (en)	2022-10-05	2024-04-11	Genentech, Inc.	Methods and compositions for classifying and treating lung cancer
US20240174732A1 (en)	2022-10-05	2024-05-30	Flagship Pioneering Innovations V, Inc.	Nucleic acid molecules encoding trif and additional polypeptides and their use in treating cancer
WO2024077095A1 (en)	2022-10-05	2024-04-11	Genentech, Inc.	Methods and compositions for classifying and treating bladder cancer
WO2024081385A1 (en)	2022-10-14	2024-04-18	Arcus Biosciences, Inc.	Hpk1 inhibitors and methods of use thereof
WO2024086827A2 (en)	2022-10-20	2024-04-25	Repertoire Immune Medicines, Inc.	Cd8 t cell targeted il2
WO2024086718A1 (en)	2022-10-20	2024-04-25	Arcus Biosciences, Inc.	Lyophilized formulations of cd73 compounds
WO2024089417A1 (en)	2022-10-24	2024-05-02	Memorial Sloan-Kettering Cancer Center	Tumour stratification for responsiveness to an immune checkpoint inhibitor
WO2024089418A1 (en)	2022-10-24	2024-05-02	Cancer Research Technology Limited	Tumour sensitisation to checkpoint inhibitors with redox status modifier
WO2024091991A1 (en)	2022-10-25	2024-05-02	Genentech, Inc.	Therapeutic and diagnostic methods for multiple myeloma
WO2024102635A1 (en)	2022-11-07	2024-05-16	Alector Llc	Uses of siglec-9 ecd fusion molecules in cancer treatment
WO2024112894A1 (en)	2022-11-22	2024-05-30	PIC Therapeutics, Inc.	Eif4e inhibitors and uses thereof
TW202440157A (zh)	2022-12-01	2024-10-16	英商梅迪繆思有限公司	用於治療癌症的組合療法
WO2024115725A1 (en)	2022-12-01	2024-06-06	BioNTech SE	Multispecific antibody against cd40 and cd137 in combination therapy with anti-pd1 ab and chemotherapy
WO2024126457A1 (en)	2022-12-14	2024-06-20	Astellas Pharma Europe Bv	Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and immune checkpoint inhibitors
WO2024137589A2 (en)	2022-12-20	2024-06-27	Genentech, Inc.	Methods of treating pancreatic cancer with a pd-1 axis binding antagonist and an rna vaccine
WO2024137776A1 (en)	2022-12-21	2024-06-27	Bristol-Myers Squibb Company	Combination therapy for lung cancer
WO2024137865A1 (en)	2022-12-22	2024-06-27	Gossamer Bio Services, Inc.	Compounds useful as t cell activators
WO2024145291A2 (en) *	2022-12-29	2024-07-04	Development Center For Biotechnology	Fusion protein targeting pd-l1 and neutralizing gas6 and uses thereof
US20240269251A1 (en)	2023-01-09	2024-08-15	Flagship Pioneering Innovations V, Inc.	Genetic switches and their use in treating cancer
WO2024150177A1 (en)	2023-01-11	2024-07-18	Advesya	Treatment methods for solid tumors
WO2024150017A1 (en)	2023-01-13	2024-07-18	Akrivia Biomedics Limited	Method of profiling diseases
US20240294651A1 (en)	2023-01-30	2024-09-05	Kymab Limited	Antibodies
WO2024175699A1 (en)	2023-02-23	2024-08-29	Imcheck Therapeutics	Combination of btn3a activating antibody and immune checkpoint inhibitors
WO2024192033A1 (en)	2023-03-13	2024-09-19	Regeneron Pharmaceuticals, Inc.	Combination of pd-1 inhibitors and lag-3 inhibitors for enhanced efficacy in treating melanoma
WO2024196952A1 (en)	2023-03-20	2024-09-26	Bristol-Myers Squibb Company	Tumor subtype assessment for cancer therapy
WO2024209072A1 (en)	2023-04-06	2024-10-10	Genmab A/S	Multispecific binding agents against pd-l1 and cd137 for treating cancer
WO2024216028A1 (en)	2023-04-12	2024-10-17	Agenus Inc.	Methods of treating cancer using an anti-ctla4 antibody and an enpp1 inhibitor
US20240425497A1 (en)	2023-05-05	2024-12-26	Arcus Biosciences, Inc.	Cbl-b Inhibitors and Methods of Use Thereof
WO2024233341A1 (en)	2023-05-05	2024-11-14	Genentech, Inc.	Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
KR20250019700A (ko)	2023-05-08	2025-02-10	브리스톨-마이어스 스큅 컴퍼니	치환된 페닐 옥사졸론 화합물
WO2024233900A1 (en)	2023-05-10	2024-11-14	Blueprint Medicines Corporation	Gsk3a inhibitors and methods of use thereof
WO2024233646A1 (en)	2023-05-10	2024-11-14	Genentech, Inc.	Methods and compositions for treating cancer
WO2024236048A1 (en)	2023-05-16	2024-11-21	Nh Theraguix	Combination therapy for treating tumors with radiotherapy
WO2024243502A1 (en)	2023-05-25	2024-11-28	Arcus Biosciences, Inc.	Cbl-b inhibitors and methods of use thereof
WO2024249540A1 (en)	2023-05-31	2024-12-05	Bristol-Myers Squibb Company	Substituted oxazolone compound for decreasing levels of ikzf1-4 proteins
WO2024249894A2 (en)	2023-06-02	2024-12-05	Arcus Biosciences, Inc.	Biomarkers for predicting cancer treatment efficacy
WO2024254227A1 (en)	2023-06-07	2024-12-12	Bristol-Myers Squibb Company	Spirocyclic substituted oxoisoindolinyl piperidine-2,6-dione compound
WO2024261239A1 (en)	2023-06-23	2024-12-26	Imcheck Therapeutics	Bispecific antibodies targeting btn3a and the pd-1/pd-l1 inhibitory axis
WO2024263195A1 (en)	2023-06-23	2024-12-26	Genentech, Inc.	Methods for treatment of liver cancer
WO2024263853A1 (en)	2023-06-23	2024-12-26	Bristol-Myers Squibb Company	Substituted oxoisoindolinyl piperidine-2,6-dione compound as anticancer agent
WO2024263904A1 (en)	2023-06-23	2024-12-26	Genentech, Inc.	Methods for treatment of liver cancer
WO2025006811A1 (en)	2023-06-27	2025-01-02	Lyell Immunopharma, Inc.	Methods for culturing immune cells
WO2025024257A1 (en)	2023-07-21	2025-01-30	Genentech, Inc.	Diagnostic and therapeutic methods for cancer
WO2025030002A2 (en)	2023-08-02	2025-02-06	Arvinas Operations, Inc.	Dgk targeting compounds and uses thereof
WO2025038763A1 (en)	2023-08-15	2025-02-20	Bristol-Myers Squibb Company	Ceramic hydroxyapatite chromatography flow through method
WO2025038857A1 (en)	2023-08-16	2025-02-20	Arcus Biosciences, Inc.	TETRALINS TARGETING MUTANT HIF-2α
WO2025049277A1 (en)	2023-08-25	2025-03-06	Genentech, Inc.	Methods and compositions for treating non-small cell lung cancer comprising an anti-tigit antagonist antibody and a pd-1 axis binding antagonist
WO2025049840A1 (en)	2023-09-02	2025-03-06	Bristol-Myers Squibb Company	Substituted phenyl oxooxazolyl piperidine dione compounds
US20250075000A1 (en)	2023-09-06	2025-03-06	Novimmune Sa	Combination therapy with a cea x cd28 bispecific antibody and blocking anti-pd-1 antibodies for enhanced in vivo anti-tumor activity
WO2025054339A1 (en)	2023-09-08	2025-03-13	Arcus Biosciences, Inc.	Triazolopyridine compounds as inhibitors of kit
US20250084056A1 (en)	2023-09-13	2025-03-13	Bristol-Myers Squibb Company	Substituted oxoisoindolinyl piperidine-2,6-dione compounds
WO2025056180A1 (en)	2023-09-15	2025-03-20	BioNTech SE	Methods of treatment using agents binding to epcam and cd137 in combination with pd-1 axis binding antagonists

Family Cites Families (144)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US529054A (en)		1894-11-13		Alfred zempliner
US598520A (en)		1898-02-08		Marker s record for laundrymen
US4179337A (en)	1973-07-20	1979-12-18	Davis Frank F	Non-immunogenic polypeptides
US4444887A (en)	1979-12-10	1984-04-24	Sloan-Kettering Institute	Process for making human antibody producing B-lymphocytes
US4485045A (en)	1981-07-06	1984-11-27	Research Corporation	Synthetic phosphatidyl cholines useful in forming liposomes
DE3378250D1 (en)	1982-04-22	1988-11-24	Ici Plc	Continuous release formulations
US4716111A (en)	1982-08-11	1987-12-29	Trustees Of Boston University	Process for producing human antibodies
US4741900A (en)	1982-11-16	1988-05-03	Cytogen Corporation	Antibody-metal ion complexes
GB8308235D0 (en)	1983-03-25	1983-05-05	Celltech Ltd	Polypeptides
US4816567A (en)	1983-04-08	1989-03-28	Genentech, Inc.	Recombinant immunoglobin preparations
US4544545A (en)	1983-06-20	1985-10-01	Trustees University Of Massachusetts	Liposomes containing modified cholesterol for organ targeting
US5807715A (en)	1984-08-27	1998-09-15	The Board Of Trustees Of The Leland Stanford Junior University	Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US5128326A (en)	1984-12-06	1992-07-07	Biomatrix, Inc.	Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
US4980286A (en)	1985-07-05	1990-12-25	Whitehead Institute For Biomedical Research	In vivo introduction and expression of foreign genetic material in epithelial cells
US4676980A (en)	1985-09-23	1987-06-30	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Target specific cross-linked heteroantibodies
US5225539A (en)	1986-03-27	1993-07-06	Medical Research Council	Recombinant altered antibodies and methods of making altered antibodies
GB8607679D0 (en)	1986-03-27	1986-04-30	Winter G P	Recombinant dna product
US4946778A (en)	1987-09-21	1990-08-07	Genex Corporation	Single polypeptide chain binding molecules
EP0307434B2 (en)	1987-03-18	1998-07-29	Scotgen Biopharmaceuticals, Inc.	Altered antibodies
US5258498A (en)	1987-05-21	1993-11-02	Creative Biomolecules, Inc.	Polypeptide linkers for production of biosynthetic proteins
US4880078A (en)	1987-06-29	1989-11-14	Honda Giken Kogyo Kabushiki Kaisha	Exhaust muffler
JP3095168B2 (ja)	1988-02-05	2000-10-03	エル．モリソン，シェリー	ドメイン‐変性不変部を有する抗体
EP1997891A1 (en)	1988-09-02	2008-12-03	Dyax Corporation	Generation and selection of recombinant varied binding proteins
US5223409A (en)	1988-09-02	1993-06-29	Protein Engineering Corp.	Directed evolution of novel binding proteins
US5530101A (en)	1988-12-28	1996-06-25	Protein Design Labs, Inc.	Humanized immunoglobulins
US20030229208A1 (en)	1988-12-28	2003-12-11	Protein Design Labs, Inc.	Humanized immunoglobulins
US5413923A (en)	1989-07-25	1995-05-09	Cell Genesys, Inc.	Homologous recombination for universal donor cells and chimeric mammalian hosts
AU6430190A (en)	1989-10-10	1991-05-16	Pitman-Moore, Inc.	Sustained release composition for macromolecular proteins
US5013556A (en)	1989-10-20	1991-05-07	Liposome Technology, Inc.	Liposomes with enhanced circulation time
CA2071867A1 (en)	1989-11-06	1991-05-07	Edith Mathiowitz	Method for producing protein microspheres
GB8928874D0 (en)	1989-12-21	1990-02-28	Celltech Ltd	Humanised antibodies
AU7247191A (en)	1990-01-11	1991-08-05	Molecular Affinities Corporation	Production of antibodies using gene libraries
US5780225A (en)	1990-01-12	1998-07-14	Stratagene	Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
ATE356869T1 (de)	1990-01-12	2007-04-15	Amgen Fremont Inc	Bildung von xenogenen antikörpern
US5427908A (en)	1990-05-01	1995-06-27	Affymax Technologies N.V.	Recombinant library screening methods
GB9015198D0 (en)	1990-07-10	1990-08-29	Brien Caroline J O	Binding substance
US5661016A (en)	1990-08-29	1997-08-26	Genpharm International Inc.	Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5545806A (en)	1990-08-29	1996-08-13	Genpharm International, Inc.	Ransgenic non-human animals for producing heterologous antibodies
US5633425A (en)	1990-08-29	1997-05-27	Genpharm International, Inc.	Transgenic non-human animals capable of producing heterologous antibodies
US5625126A (en)	1990-08-29	1997-04-29	Genpharm International, Inc.	Transgenic non-human animals for producing heterologous antibodies
DE69127627T2 (de)	1990-08-29	1998-02-19	Genpharm Int	Produktion und Nützung nicht-menschliche transgentiere zur Produktion heterologe Antikörper
US5814318A (en)	1990-08-29	1998-09-29	Genpharm International Inc.	Transgenic non-human animals for producing heterologous antibodies
US5698426A (en)	1990-09-28	1997-12-16	Ixsys, Incorporated	Surface expression libraries of heteromeric receptors
DE69129154T2 (de)	1990-12-03	1998-08-20	Genentech, Inc., South San Francisco, Calif.	Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
AU662148B2 (en)	1991-04-10	1995-08-24	Scripps Research Institute, The	Heterodimeric receptor libraries using phagemids
JPH06507404A (ja)	1991-05-01	1994-08-25	ヘンリー　エム．ジャクソン　ファウンデイション　フォー　ザ　アドバンスメント　オブ　ミリタリー　メディスン	感染性の呼吸性疾患の治療方法
EP0519596B1 (en)	1991-05-17	2005-02-23	Merck & Co. Inc.	A method for reducing the immunogenicity of antibody variable domains
DE122004000008I1 (de)	1991-06-14	2005-06-09	Genentech Inc	Humanisierter Heregulin Antikörper.
CA2110799A1 (en)	1991-06-14	1992-12-23	Arnold H. Horwitz	Microbially-produced antibody fragments and their conjugates
US6787153B1 (en)	1991-06-28	2004-09-07	Mitsubishi Chemical Corporation	Human monoclonal antibody specifically binding to surface antigen of cancer cell membrane
ES2136092T3 (es)	1991-09-23	1999-11-16	Medical Res Council	Procedimientos para la produccion de anticuerpos humanizados.
PT1024191E (pt)	1991-12-02	2008-12-22	Medical Res Council	Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos
US5766886A (en)	1991-12-13	1998-06-16	Xoma Corporation	Modified antibody variable domains
GB9203459D0 (en)	1992-02-19	1992-04-08	Scotgen Ltd	Antibodies with germ-line variable regions
US5714350A (en)	1992-03-09	1998-02-03	Protein Design Labs, Inc.	Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
US5912015A (en)	1992-03-12	1999-06-15	Alkermes Controlled Therapeutics, Inc.	Modulated release from biocompatible polymers
US5733743A (en)	1992-03-24	1998-03-31	Cambridge Antibody Technology Limited	Methods for producing members of specific binding pairs
EP0656946B2 (en)	1992-08-21	2010-03-31	Vrije Universiteit Brussel	Immunoglobulins devoid of light chains
US6005079A (en)	1992-08-21	1999-12-21	Vrije Universiteit Brussels	Immunoglobulins devoid of light chains
US5639641A (en)	1992-09-09	1997-06-17	Immunogen Inc.	Resurfacing of rodent antibodies
CH686365A5 (de)	1992-10-06	1996-03-15	Werner Hofliger	Mobilkran.
US5441050A (en)	1992-12-18	1995-08-15	Neoprobe Corporation	Radiation responsive surgical instrument
US5934272A (en)	1993-01-29	1999-08-10	Aradigm Corporation	Device and method of creating aerosolized mist of respiratory drug
AU6796094A (en)	1993-04-29	1994-11-21	Raymond Hamers	Production of antibodies or (functionalized) fragments thereof derived from heavy chain immunoglobulins of (camelidae)
EP0733070A1 (en)	1993-12-08	1996-09-25	Genzyme Corporation	Process for generating specific antibodies
ES2201097T3 (es)	1994-01-31	2004-03-16	Trustees Of Boston University	Bibliotecas de anticuerpos policlonales.
US5516637A (en)	1994-06-10	1996-05-14	Dade International Inc.	Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
US6962686B2 (en)	1994-10-12	2005-11-08	California Institute Of Technology	Cell-specific gene delivery vehicles
US6214388B1 (en)	1994-11-09	2001-04-10	The Regents Of The University Of California	Immunoliposomes that optimize internalization into target cells
JPH10511957A (ja)	1995-01-05	1998-11-17	ザボードオブリージェンツオブザユニヴァーシティオブミシガン	表面改質ナノ微粒子並びにその製造及び使用方法
US6019968A (en)	1995-04-14	2000-02-01	Inhale Therapeutic Systems, Inc.	Dispersible antibody compositions and methods for their preparation and use
EP1978033A3 (en)	1995-04-27	2008-12-24	Amgen Fremont Inc.	Human antibodies derived from immunized xenomice
CA2219486A1 (en)	1995-04-28	1996-10-31	Abgenix, Inc.	Human antibodies derived from immunized xenomice
WO1997007788A2 (en)	1995-08-31	1997-03-06	Alkermes Controlled Therapeutics, Inc.	Composition for sustained release of an agent
US5736152A (en)	1995-10-27	1998-04-07	Atrix Laboratories, Inc.	Non-polymeric sustained release delivery system
JP2978435B2 (ja)	1996-01-24	1999-11-15	チッソ株式会社	アクリロキシプロピルシランの製造方法
US5942328A (en)	1996-02-29	1999-08-24	International Business Machines Corporation	Low dielectric constant amorphous fluorinated carbon and method of preparation
US5985320A (en)	1996-03-04	1999-11-16	The Penn State Research Foundation	Materials and methods for enhancing cellular internalization
US5985309A (en)	1996-05-24	1999-11-16	Massachusetts Institute Of Technology	Preparation of particles for inhalation
US5855913A (en)	1997-01-16	1999-01-05	Massachusetts Instite Of Technology	Particles incorporating surfactants for pulmonary drug delivery
US5874064A (en)	1996-05-24	1999-02-23	Massachusetts Institute Of Technology	Aerodynamically light particles for pulmonary drug delivery
US5916771A (en)	1996-10-11	1999-06-29	Abgenix, Inc.	Production of a multimeric protein by cell fusion method
WO1998023289A1 (en)	1996-11-27	1998-06-04	The General Hospital Corporation	MODULATION OF IgG BINDING TO FcRn
JP4215172B2 (ja)	1996-12-03	2009-01-28	アムジェンフレモントインク．	複数のＶ▲下Ｈ▼およびＶ▲下κ▼領域を含むヒトＩｇ遺伝子座を有するトランスジェニック哺乳動物、ならびにそれから産生される抗体
EP0954282B1 (en)	1997-01-16	2005-01-19	Massachusetts Institute Of Technology	Preparation of particles for inhalation
US6277375B1 (en)	1997-03-03	2001-08-21	Board Of Regents, The University Of Texas System	Immunoglobulin-like domains with increased half-lives
ATE200679T1 (de)	1997-04-14	2001-05-15	Micromet Ag	Neues verfahren zur herstellung von anti-humanen antigenrezeptoren und deren verwendungen
US6235883B1 (en)	1997-05-05	2001-05-22	Abgenix, Inc.	Human monoclonal antibodies to epidermal growth factor receptor
US5989463A (en)	1997-09-24	1999-11-23	Alkermes Controlled Therapeutics, Inc.	Methods for fabricating polymer-based controlled release devices
SE512663C2 (sv)	1997-10-23	2000-04-17	Biogram Ab	Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer
US5843597A (en)	1997-12-01	1998-12-01	Eveready Battery Company, Inc.	Ribbed gasket for miniature galvanic cell
US6982323B1 (en)	1997-12-23	2006-01-03	Alexion Pharmaceuticals, Inc.	Chimeric proteins for diagnosis and treatment of diabetes
US6194551B1 (en)	1998-04-02	2001-02-27	Genentech, Inc.	Polypeptide variants
PT1068241E (pt)	1998-04-02	2007-11-19	Genentech Inc	Variantes de anticorpos e respectivos fragmentos
GB9809951D0 (en)	1998-05-08	1998-07-08	Univ Cambridge Tech	Binding molecules
ES2198922T3 (es)	1998-06-24	2004-02-01	Advanced Inhalation Research, Inc.	Particulas porosas grandes emitadas por un inhalador.
US6311415B1 (en)	1998-09-14	2001-11-06	Lind Shoe Company	Bowling shoe with replaceable tip
MX353234B (es)	1999-01-15	2018-01-08	Genentech Inc	Variantes de polipeptidos con función efectora alterada.
US7780882B2 (en)	1999-02-22	2010-08-24	Georgetown University	Simplified and improved method for preparing an antibody or an antibody fragment targeted immunoliposome for systemic administration of a therapeutic or diagnostic agent
HU228477B1 (en)	1999-08-23	2013-03-28	Dana Farber Cancer Inst Inc	Pd-1, a receptor for b7-4, and uses therefor
PL362804A1 (en)	1999-08-23	2004-11-02	Dana-Farber Cancer Institute	Novel b7-4 molecules and uses therefor
US6890487B1 (en)	1999-09-30	2005-05-10	Science & Technology Corporation ©UNM	Flow cytometry for high throughput screening
US6803192B1 (en)	1999-11-30	2004-10-12	Mayo Foundation For Medical Education And Research	B7-H1, a novel immunoregulatory molecule
PT1234031T (pt)	1999-11-30	2017-06-26	Mayo Foundation	B7-h1, uma nova molécula imunoregulatória
US6784981B1 (en)	2000-06-02	2004-08-31	Idexx Laboratories, Inc.	Flow cytometry-based hematology system
US7262838B2 (en)	2001-06-29	2007-08-28	Honeywell International Inc.	Optical detection system for flow cytometry
US6794152B2 (en)	2000-12-22	2004-09-21	Streck Laboratories Inc.	Flow cytometry reagent and system
AR036993A1 (es)	2001-04-02	2004-10-20	Wyeth Corp	Uso de agentes que modulan la interaccion entre pd-1 y sus ligandos en la submodulacion de respuestas inmunologicas
AU2002258941A1 (en)	2001-04-20	2002-11-05	Mayo Foundation For Medical Education And Research	Methods of enhancing cell responsiveness
US7479630B2 (en)	2004-03-25	2009-01-20	Bandura Dmitry R	Method and apparatus for flow cytometry linked with elemental analysis
US20040241745A1 (en)	2001-07-31	2004-12-02	Tasuku Honjo	Substance specific to pd-1
WO2003042402A2 (en)	2001-11-13	2003-05-22	Dana-Farber Cancer Institute, Inc.	Agents that modulate immune cell activation and methods of use thereof
DE60334303D1 (de)	2002-07-03	2010-11-04	Tasuku Honjo	Immunpotenzierende zusammensetzungen
FR2844513B1 (fr)	2002-09-13	2007-08-03	Lab Francais Du Fractionnement	Anticorps pour adcc et induisant la production de cytokines.
FR2844455B1 (fr)	2002-09-13	2007-12-14	Lab Francais Du Fractionnement	Traitement des pathologies echappant a la reponse immune par des anticorps optimises
DK1553975T3 (da)	2002-09-27	2012-05-07	Xencor Inc	Optimerede Fc-varianter og fremgangsmåder til generering heraf.
AU2003288675B2 (en)	2002-12-23	2010-07-22	Medimmune Limited	Antibodies against PD-1 and uses therefor
US7960512B2 (en)	2003-01-09	2011-06-14	Macrogenics, Inc.	Identification and engineering of antibodies with variant Fc regions and methods of using same
WO2004063351A2 (en)	2003-01-09	2004-07-29	Macrogenics, Inc.	IDENTIFICATION AND ENGINEERING OF ANTIBODIES WITH VARIANT Fc REGIONS AND METHODS OF USING SAME
EP2270051B1 (en)	2003-01-23	2019-05-15	Ono Pharmaceutical Co., Ltd.	Antibody specific for human PD-1 and CD3
US7507548B2 (en)	2003-03-04	2009-03-24	University Of Salamanca	Multidimensional detection of aberrant phenotypes in neoplastic cells to be used to monitor minimal disease levels using flow cytometry measurements
US7354773B2 (en)	2003-05-14	2008-04-08	Beckman Coulter, Inc.	Method and apparatus for preparing cell samples for intracellular antigen detection using flow cytometry
WO2005091893A2 (en)	2004-03-03	2005-10-06	Dakocytomation Denmark A/S	System for high dynamic range analysis in flow cytometry
US7465543B1 (en)	2004-05-21	2008-12-16	The United States Of America, As Represented By The Secretary Of Agriculture	Multiplex DNA identification of clinical yeasts using flow cytometry
US7527978B2 (en)	2004-10-07	2009-05-05	Children's Hospital & Research Center At Oakland	Flow cytometry based micronucleus assays and kits
AU2005295579B2 (en)	2004-10-15	2011-08-04	NortonLifeLock Inc.	One time password
WO2006056875A1 (en) *	2004-11-29	2006-06-01	Pharmacia & Upjohn Company Llc	Thiazepine oxazolidinones as antibacterial agents
US7491502B2 (en)	2004-12-17	2009-02-17	The General Hospital Corporation	In vivo flow cytometry system and method
AU2006244885B2 (en) *	2005-05-09	2011-03-31	E. R. Squibb & Sons, L.L.C.	Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
SG10201702670VA (en)	2005-06-08	2017-06-29	Dana Farber Cancer Inst Inc	Methods and compositions for the treatment of persistent infections and cancer by inhibiting the programmed cell death 1 (pd-1) pathway
KR101888321B1 (ko)	2005-07-01	2018-08-13	이. 알. 스퀴부 앤드 선즈, 엘.엘.씨.	예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체
EP2062056B1 (en)	2006-09-29	2019-04-10	Luminex Corporation	Differentiation of flow cytometry pulses and applications
BRPI0720724A2 (pt) *	2006-12-27	2014-04-01	Univ Emory	Composições e métodos para o tratamento de infecções e tumores
CN101236150B (zh)	2007-02-02	2012-09-05	深圳迈瑞生物医疗电子股份有限公司	用于基于流式细胞术的仪器的光电传感器及其照射单元
US7746466B2 (en)	2007-05-14	2010-06-29	The Regents Of The University Of California	System and method for flow cytometry
WO2008156712A1 (en) *	2007-06-18	2008-12-24	N. V. Organon	Antibodies to human programmed death receptor pd-1
US8062852B2 (en)	2007-10-01	2011-11-22	The Children's Hospital And Regional Medical Center	Detection and treatment of autoimmune disorders
AU2009213738B2 (en) *	2008-02-11	2015-01-22	Curetech Ltd.	Monoclonal antibodies for tumor treatment
EP2262837A4 (en) *	2008-03-12	2011-04-06	Merck Sharp & Dohme	PD-1 BINDING PROTEINS
AU2009290544B2 (en) *	2008-09-12	2015-07-16	Oxford University Innovation Limited	PD-1 specific antibodies and uses thereof
EP2342228B1 (en) *	2008-09-12	2017-09-06	Oxford University Innovation Limited	Pd-1 specific antibodies and uses thereof
AU2009296392B2 (en) *	2008-09-26	2016-06-02	Dana-Farber Cancer Institute, Inc.	Human anti-PD-1, PD-L1, and PD-L2 antibodies and uses therefor
ES2629337T3 (es) *	2009-02-09	2017-08-08	Inserm - Institut National De La Santé Et De La Recherche Médicale	Anticuerpos contra PD-1 y anticuerpos contra PD-L1 y usos de los mismos
TW201134488A (en) *	2010-03-11	2011-10-16	Ucb Pharma Sa	PD-1 antibodies

2012
- 2012-04-19 LT LTEP12774724.4T patent/LT2699264T/lt unknown
- 2012-04-19 RU RU2013151455A patent/RU2625034C2/ru not_active IP Right Cessation
- 2012-04-19 ES ES12774724.4T patent/ES2669310T3/es active Active
- 2012-04-19 HU HUE12774724A patent/HUE037651T2/hu unknown
- 2012-04-19 SI SI201231320T patent/SI2699264T1/en unknown
- 2012-04-19 AU AU2012245477A patent/AU2012245477C1/en not_active Ceased
- 2012-04-19 DK DK12774724.4T patent/DK2699264T3/en active
- 2012-04-19 EP EP18161596.4A patent/EP3403672A1/en not_active Withdrawn
- 2012-04-19 RS RS20180683A patent/RS57324B1/sr unknown
- 2012-04-19 SM SM20180294T patent/SMT201800294T1/it unknown
- 2012-04-19 CN CN201280030691.9A patent/CN103608040B/zh not_active Expired - Fee Related
- 2012-04-19 PT PT127747244T patent/PT2699264T/pt unknown
- 2012-04-19 WO PCT/US2012/034223 patent/WO2012145493A1/en active Application Filing
- 2012-04-19 KR KR1020137030691A patent/KR101970025B1/ko not_active Expired - Fee Related
- 2012-04-19 MX MX2013012088A patent/MX338353B/es active IP Right Grant
- 2012-04-19 US US14/111,402 patent/US9205148B2/en not_active Expired - Fee Related
- 2012-04-19 JP JP2014506544A patent/JP6072771B2/ja not_active Expired - Fee Related
- 2012-04-19 CA CA2833636A patent/CA2833636A1/en not_active Abandoned
- 2012-04-19 EP EP12774724.4A patent/EP2699264B1/en active Active
- 2012-04-19 PL PL12774724T patent/PL2699264T3/pl unknown
2015
- 2015-10-29 US US14/926,732 patent/US20160130348A1/en not_active Abandoned
2016
- 2016-12-28 JP JP2016254558A patent/JP2017101042A/ja active Pending
2018
- 2018-06-07 HR HRP20180893TT patent/HRP20180893T1/hr unknown
- 2018-06-13 CY CY181100615T patent/CY1120626T1/el unknown

Also Published As

Publication number	Publication date
US20140044738A1 (en)	2014-02-13
AU2012245477C1 (en)	2017-06-15
ES2669310T3 (es)	2018-05-24
HUE037651T2 (hu)	2018-09-28
EP2699264B1 (en)	2018-03-14
EP2699264A4 (en)	2014-10-08
DK2699264T3 (en)	2018-06-25
SI2699264T1 (en)	2018-08-31
PL2699264T3 (pl)	2018-08-31
KR101970025B1 (ko)	2019-04-17
MX2013012088A (es)	2014-04-30
US9205148B2 (en)	2015-12-08
CY1120626T1 (el)	2019-12-11
JP6072771B2 (ja)	2017-02-01
CN103608040B (zh)	2017-03-01
RS57324B1 (sr)	2018-08-31
RU2013151455A (ru)	2015-05-27
CA2833636A1 (en)	2012-10-26
KR20140048121A (ko)	2014-04-23
MX338353B (es)	2016-04-13
LT2699264T (lt)	2018-07-10
WO2012145493A1 (en)	2012-10-26
EP2699264A1 (en)	2014-02-26
JP2014523401A (ja)	2014-09-11
RU2625034C2 (ru)	2017-07-11
EP3403672A1 (en)	2018-11-21
JP2017101042A (ja)	2017-06-08
AU2012245477A1 (en)	2013-10-31
HRP20180893T1 (hr)	2018-07-27
US20160130348A1 (en)	2016-05-12
SMT201800294T1 (it)	2018-07-17
AU2012245477B2 (en)	2017-03-23
CN103608040A (zh)	2014-02-26

Publication	Publication Date	Title
PT2699264T (pt)	2018-05-23	Anticorpos e outras moléculas que ligam b7-h1 e pd-1
CY2023014I2 (el)	2023-11-15	Αντι il-36r αντισωματα
HUS2400016I1 (hu)	2024-06-28	FCRN elleni antitestek
CY2021036I1 (el)	2022-03-24	Αντισωματα anti-angptl3 και χρησεις αυτων
IL249650A0 (en)	2017-02-28	Antibodies directed against icos and uses thereof
IL229575B (en)	2018-05-31	Cd3-binding molecules capable of binding to human and non-human cd3
HK1222204A1 (zh)	2017-06-23	用於轉染細胞的方法和產品
BR112014012137A2 (pt)	2017-05-30	anticorpos anti-fgfr2 e suas utilizações
LT2780375T (lt)	2019-11-11	Bcma ir cd3 prijungiančios molekulės
DK3156416T3 (da)	2020-02-24	Sekvenssymmetriske modificerede bispecifikke igg4-antistoffer
CO7010784A2 (es)	2014-07-31	Moléculas que son anticuerpos con especificidad por ox40 humano
ME03512B (me)	2020-04-20	Cd47 antitijela i postupci za njihovu upotrebu
EP2714735A4 (en)	2014-12-31	SPECIFIC ANTIBODIES OF TGF BETA
EP2683406A4 (en)	2014-09-24	ANTI-CD40 ANTIBODY AND ITS USE
EP2755688A4 (en)	2014-08-06	HUMANIZED ANTIBODIES AGAINST INKT
DK3202789T3 (da)	2020-05-18	Anti-vla-4-antistoffer
HK1246326A1 (zh)	2018-09-07	結合凝血酶的抗體分子及其應用
EP2772946A4 (en)	2015-05-27	SOLAR CELL MODULE AND SOLAR CELLAR ARRAY
EP2699272A4 (en)	2014-10-15	TARGETED CONTRASTING AGENTS AND USES THEREOF
HK1193547A1 (zh)	2014-09-26	方法和產品
CO6841994A2 (es)	2014-01-20	Anticuerpos
LT2742068T (lt)	2019-07-10	Nauji antikūnai prieš fosforilcholiną
FI20105096L (fi)	2011-08-03	Vahvistettu rakennemoduuli ja menetelmä sen valmistamiseksi
BR112014000251A2 (pt)	2017-02-14	enzimas que sintetizam zingibereno
TH1401003664B (th)	2016-05-10	โครงสร้างสำหรับเชื่อมต่อแผงและวิธีการเชื่อมต่อแผง