MX2019013498A - Receptor de antigeno quimerico y metodos para usarlo. - Google Patents
Receptor de antigeno quimerico y metodos para usarlo.Info
- Publication number
- MX2019013498A MX2019013498A MX2019013498A MX2019013498A MX2019013498A MX 2019013498 A MX2019013498 A MX 2019013498A MX 2019013498 A MX2019013498 A MX 2019013498A MX 2019013498 A MX2019013498 A MX 2019013498A MX 2019013498 A MX2019013498 A MX 2019013498A
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- Prior art keywords
- car
- antigen receptor
- chemerical
- methods
- present disclosure
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C07K2317/622—Single chain antibody (scFv)
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- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
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Abstract
La presente descripción proporciona un receptor de antígeno quimérico (CAR) condicionalmente activo y heterodimérico, y un ácido nucleico que comprende una secuencia de nucleótidos que codifica el CAR. La presente descripción proporciona células genéticamente modificadas para producir el CAR. Un CAR de la presente descripción se puede utilizar en varios métodos, que también se proporcionan.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361765585P | 2013-02-15 | 2013-02-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019013498A true MX2019013498A (es) | 2020-01-20 |
Family
ID=51354582
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015010522A MX369545B (es) | 2013-02-15 | 2014-02-14 | Receptor de antígeno químerico y métodos para usarlo. |
MX2019013498A MX2019013498A (es) | 2013-02-15 | 2015-08-14 | Receptor de antigeno quimerico y metodos para usarlo. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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MX2015010522A MX369545B (es) | 2013-02-15 | 2014-02-14 | Receptor de antígeno químerico y métodos para usarlo. |
Country Status (21)
Country | Link |
---|---|
US (9) | US20150368342A1 (es) |
EP (5) | EP4303232A3 (es) |
JP (5) | JP6450690B2 (es) |
KR (5) | KR20230022452A (es) |
CN (2) | CN105142677B (es) |
AU (5) | AU2014216130B2 (es) |
CA (1) | CA2901115A1 (es) |
CY (1) | CY1122386T1 (es) |
DK (2) | DK3300745T3 (es) |
ES (3) | ES2868247T3 (es) |
HK (2) | HK1218625A1 (es) |
HR (1) | HRP20192123T1 (es) |
HU (2) | HUE047487T2 (es) |
IL (3) | IL305629A (es) |
LT (2) | LT2956175T (es) |
MX (2) | MX369545B (es) |
NO (1) | NO2929995T3 (es) |
PL (3) | PL2956175T3 (es) |
PT (3) | PT3300745T (es) |
SI (2) | SI3613439T1 (es) |
WO (1) | WO2014127261A1 (es) |
Families Citing this family (301)
Publication number | Priority date | Publication date | Assignee | Title |
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US9428567B2 (en) | 2010-12-22 | 2016-08-30 | The Board Of Trustees Of The Leland Stanford Junior University | Antagonists of interleukin-2 receptor |
CA2874611C (en) * | 2012-05-25 | 2023-01-24 | Cellectis | Use of pre t alpha or functional variant thereof for expanding tcr alpha deficient t cells |
WO2014100615A1 (en) | 2012-12-20 | 2014-06-26 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
US9511092B2 (en) | 2013-01-28 | 2016-12-06 | St. Jude Children's Research Hospital, Inc. | Chimeric receptor with NKG2D specificity for use in cell therapy against cancer and infectious disease |
DK3300745T3 (da) | 2013-02-15 | 2019-11-04 | Univ California | Kimærisk antigenreceptor og fremgangsmåder til anvendelse deraf |
EP2968502B1 (en) | 2013-03-14 | 2020-08-26 | Bellicum Pharmaceuticals, Inc. | Methods for controlling t cell proliferation |
EP3623380A1 (en) * | 2013-03-15 | 2020-03-18 | Michael C. Milone | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
WO2015017214A1 (en) | 2013-07-29 | 2015-02-05 | Bluebird Bio, Inc. | Multipartite signaling proteins and uses thereof |
US10781242B2 (en) | 2013-09-24 | 2020-09-22 | Medicenna Therapeutics Inc. | Interleukin-2 fusion proteins and uses thereof |
EP3083689B1 (en) | 2013-12-17 | 2020-05-27 | Genentech, Inc. | Anti-cd3 antibodies and methods of use |
WO2015090229A1 (en) | 2013-12-20 | 2015-06-25 | Novartis Ag | Regulatable chimeric antigen receptor |
EP3094354B1 (en) | 2014-01-14 | 2018-10-17 | Cellectis | Chimeric antigen receptor using antigen recognition domains derived from cartilaginous fish |
EP3104866A4 (en) | 2014-02-14 | 2017-08-02 | Bellicum Pharmaceuticals, Inc. | Methods for activating t cells using an inducible chimeric polypeptide |
US20170081411A1 (en) * | 2014-03-15 | 2017-03-23 | Novartis Ag | Regulatable chimeric antigen receptor |
GB201405845D0 (en) | 2014-04-01 | 2014-05-14 | Ucl Business Plc | Signalling system |
PL3888674T3 (pl) | 2014-04-07 | 2024-09-23 | Novartis Ag | Leczenie nowotworu złośliwego z zastosowaniem chimerycznego receptora antygenowego anty-CD19 |
CA2946398A1 (en) | 2014-04-24 | 2015-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists, partial agonists and antagonists of interleukin-2 |
SG11201609118RA (en) | 2014-05-15 | 2016-11-29 | Univ Singapore | Modified natural killer cells and uses thereof |
CN107106665A (zh) * | 2014-06-06 | 2017-08-29 | 纪念斯隆-凯特琳癌症中心 | 靶向间皮素的嵌合抗原受体及其用途 |
EP3193915A1 (en) | 2014-07-21 | 2017-07-26 | Novartis AG | Combinations of low, immune enhancing. doses of mtor inhibitors and cars |
WO2016014553A1 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Sortase synthesized chimeric antigen receptors |
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