KR20210144725A - 항노화제, 항산화제, 항염증제 및 미백제, 그리고 화장료 - Google Patents
항노화제, 항산화제, 항염증제 및 미백제, 그리고 화장료 Download PDFInfo
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JPJP-P-2019-068953 | 2019-03-29 | ||
PCT/JP2020/014395 WO2020203933A1 (ja) | 2019-03-29 | 2020-03-27 | 抗老化剤、抗酸化剤、抗炎症剤、及び美白剤、並びに、化粧料 |
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CN113230175B (zh) * | 2021-05-28 | 2023-02-03 | 潍坊职业学院 | 一种含有梧桐提取物的化妆品以及梧桐提取物的提取方法 |
CN118217205B (zh) * | 2024-04-01 | 2025-01-24 | 广东科誉新材料有限公司 | 一种增强头发光泽的洗发香波 |
Citations (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001213757A (ja) | 2000-01-28 | 2001-08-07 | Maruzen Pharmaceut Co Ltd | メラニン産生抑制剤および美白用化粧料 |
JP2001261568A (ja) | 2000-03-16 | 2001-09-26 | Kanebo Ltd | プロフィラグリン及び/又はフィラグリン蛋白産生促進剤 |
JP2002201122A (ja) | 2000-10-24 | 2002-07-16 | Maruzen Pharmaceut Co Ltd | 美白化粧料 |
JP2002226323A (ja) | 2001-02-02 | 2002-08-14 | Maruzen Pharmaceut Co Ltd | コラーゲン産生促進剤、コラゲナーゼ阻害剤、線維芽細胞増殖作用剤、エラスターゼ阻害剤、エストロゲン様作用剤、皮膚化粧料並びに美容用飲食品 |
JP2002363054A (ja) | 2001-06-05 | 2002-12-18 | Maruzen Pharmaceut Co Ltd | フィラグリン合成促進剤、角質層保湿機能改善・増強剤および角質層遊離アミノ酸量増加剤 |
JP2002370962A (ja) | 2001-06-13 | 2002-12-24 | Maruzen Pharmaceut Co Ltd | 美白用化粧料および皮膚老化防止・改善用化粧料 |
JP2003012532A (ja) | 2001-07-06 | 2003-01-15 | Maruzen Pharmaceut Co Ltd | ヒアルロニダーゼ阻害剤、ヘキソサミニダーゼ遊離阻害剤、サイクリックampホスホジエステラーゼ阻害剤及び肌荒れ改善化粧料 |
JP2003055242A (ja) | 2001-08-06 | 2003-02-26 | Maruzen Pharmaceut Co Ltd | 皮膚化粧料並びに飲食品 |
JP2003081848A (ja) | 2001-09-13 | 2003-03-19 | Maruzen Pharmaceut Co Ltd | 活性酸素消去剤、該活性酸素消去剤を配合した化粧料及び飲食物 |
JP2003146886A (ja) | 2001-11-14 | 2003-05-21 | Noevir Co Ltd | フィラグリン合成促進剤、及び角質層保湿機能改善剤,角質層柔軟化剤,角質層遊離アミノ酸増加剤 |
JP2003146837A (ja) | 2001-11-13 | 2003-05-21 | Maruzen Pharmaceut Co Ltd | 皮膚化粧料及び美容用飲食品 |
JP2003176230A (ja) | 2001-12-12 | 2003-06-24 | Maruzen Pharmaceut Co Ltd | コラーゲン産生促進剤、エラスターゼ阻害剤、コラゲナーゼ阻害剤及び皮膚化粧料並びに美容用飲食品 |
JP2003176232A (ja) | 2001-12-12 | 2003-06-24 | Maruzen Pharmaceut Co Ltd | 皮膚外用剤及び飲食品 |
JP2004083488A (ja) | 2002-08-27 | 2004-03-18 | Maruzen Pharmaceut Co Ltd | 美白用化粧料及び美白用飲食品 |
JP2005029483A (ja) | 2003-07-09 | 2005-02-03 | Maruzen Pharmaceut Co Ltd | 活性酸素消去剤、並びに化粧料及び飲食物 |
JP2006321730A (ja) | 2005-05-17 | 2006-11-30 | Maruzen Pharmaceut Co Ltd | 抗酸化剤及び抗老化剤、並びに皮膚化粧料及び飲食物 |
JP2007008902A (ja) | 2005-07-04 | 2007-01-18 | Maruzen Pharmaceut Co Ltd | 抗炎症剤、抗酸化剤及び美白剤、並びに皮膚化粧料及び飲食物 |
JP2007176830A (ja) | 2005-12-27 | 2007-07-12 | Pola Chem Ind Inc | 皮膚バリア機能を向上させるための皮膚外用剤とその製造法 |
JP2007176835A (ja) | 2005-12-27 | 2007-07-12 | Pola Chem Ind Inc | 皮膚バリア機能を向上させるための皮膚外用剤とその製造法 |
JP2009184955A (ja) | 2008-02-06 | 2009-08-20 | Maruzen Pharmaceut Co Ltd | IV型コラーゲン産生促進剤、トランスグルタミナーゼ−1産生促進剤、セリンパルミトイルトランスフェラーゼ産生促進剤、アクアポリン3産生促進剤、インボルクリン産生促進剤、HMG−CoA還元酵素産生促進剤、及び、アデノシン三リン酸産生促進剤。 |
JP2009191039A (ja) | 2008-02-15 | 2009-08-27 | Maruzen Pharmaceut Co Ltd | ヒアルロン酸合成酵素3mRNA発現促進剤、アクアポリン3mRNA発現促進剤、セリンパルミトイルトランスフェラーゼmRNA発現促進剤及びラミニン5産生促進剤 |
JP2010090093A (ja) | 2008-10-10 | 2010-04-22 | Maruzen Pharmaceut Co Ltd | I型コラーゲン産生促進剤、フィラグリン産生促進剤、インボルクリン産生促進剤、及びトランスグルタミナーゼ−1産生促進剤 |
JP2011130689A (ja) | 2009-12-24 | 2011-07-07 | Kirin Kyowa Foods Co Ltd | 抗酸化能を有する調味液、その製造方法、および当該調味液を含む飲食品 |
JP2011140453A (ja) | 2010-01-06 | 2011-07-21 | Tadatoshi Karatsu | 発酵薬草乾燥物の製造方法および発酵薬草粉末 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60104005A (ja) * | 1983-11-08 | 1985-06-08 | Kobayashi Kooc:Kk | 美白化粧料 |
JPH06199647A (ja) * | 1992-12-28 | 1994-07-19 | Noevir Co Ltd | 美白化粧料 |
JPH0930953A (ja) * | 1995-07-21 | 1997-02-04 | Noevir Co Ltd | 皮膚外用剤 |
JP2003061612A (ja) * | 2001-08-29 | 2003-03-04 | Amano:Kk | 健康食品用発酵液及びその製造方法。 |
KR100645385B1 (ko) * | 2005-10-05 | 2006-11-23 | 주식회사 안지오랩 | 비만 억제용 조성물 |
JP2004075645A (ja) * | 2002-08-22 | 2004-03-11 | Kanebo Ltd | 化粧料 |
JP5147805B2 (ja) * | 2004-03-15 | 2013-02-20 | 共栄化学工業株式会社 | 化粧料 |
WO2007143851A1 (en) * | 2006-06-16 | 2007-12-21 | Kefiplant Inc. | Fermented plant extracts, methods of production and uses |
JP5872158B2 (ja) * | 2008-03-11 | 2016-03-01 | 株式会社 資生堂 | 皮膚美白方法、並びに、皮膚シミ形成抑制及び/又は除去因子のスクリーニング方法 |
KR20090103823A (ko) * | 2008-03-28 | 2009-10-01 | 마루젠세이야쿠 가부시키가이샤 | 항노화제, 피부외용제 및 음식품 |
JP5822423B2 (ja) * | 2008-03-28 | 2015-11-24 | 丸善製薬株式会社 | 皮膚線維芽細胞増殖促進剤、トランスグルタミナーゼ−1産生促進剤、エラスターゼ活性阻害剤、mmp−1活性阻害剤、エストロゲン様作用剤、i型コラーゲン産生促進剤、及びuv−bダメージからの回復作用剤 |
KR100995379B1 (ko) * | 2009-12-30 | 2010-11-19 | 이동주 | 입욕제 조성물 및 그의 제조방법 |
JP2011162457A (ja) * | 2010-02-05 | 2011-08-25 | Maruzen Pharmaceut Co Ltd | 植物発酵エキス及びその製造方法、並びに化粧料 |
KR20110114801A (ko) * | 2010-04-14 | 2011-10-20 | 노옥희 | 메주,누룩을 주원료로 하고 곡류. 한약재, 과실류, 버섯류, 야채류, 수산물류를 부원료로 하여 특정 발효조를 이용한 발효효모의 제조방법 |
JP2011231030A (ja) * | 2010-04-26 | 2011-11-17 | Toyo Shinyaku Co Ltd | 美白剤 |
CN102985064B (zh) * | 2010-06-11 | 2014-11-05 | 李东柱 | 沐浴组合物及其制备方法 |
KR101951782B1 (ko) * | 2010-10-25 | 2019-02-25 | (주)아모레퍼시픽 | 녹차 추출물을 함유하는 미백용 화장료 조성물 |
KR101167295B1 (ko) * | 2011-02-22 | 2012-07-23 | 주식회사 사임당화장품 | 한방발효복합추출물을 유효성분으로 함유하는 인체 피부 노화 방지용 화장료 조성물 및 그 제조방법 |
KR20130085012A (ko) * | 2012-01-18 | 2013-07-26 | 주식회사 엘지생활건강 | 발효물을 포함하는 화장료 조성물 및 이의 제조방법 |
KR20140109221A (ko) * | 2013-03-05 | 2014-09-15 | 호서대학교 산학협력단 | 산쑥 에센셜 오일을 유효성분으로 함유하는 피부 재생용 화장료 및 피부 외용제 조성물 |
KR101835739B1 (ko) * | 2014-06-30 | 2018-03-08 | 주식회사 에스엘바이젠 | 인진쑥 추출물 또는 이의 분획물을 유효성분으로 함유하는 조성물 |
JP6433053B2 (ja) * | 2014-09-10 | 2018-12-05 | オリザ油化株式会社 | 皮脂腺細胞における脂質蓄積促進剤 |
KR101532003B1 (ko) * | 2014-10-29 | 2015-06-26 | 재단법인 금산국제인삼약초연구소 | 발효 조성물을 함유하는 피부 항산화 기능성 화장품 |
CN108968018A (zh) * | 2018-06-25 | 2018-12-11 | 贵州古香园酿造调味品有限公司 | 一种甜面酱及其制备方法 |
CN109370835A (zh) * | 2018-12-24 | 2019-02-22 | 湖北襄醉酒业有限公司 | 一种营养型南瓜白兰地酒及其制备方法 |
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2020
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Patent Citations (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001213757A (ja) | 2000-01-28 | 2001-08-07 | Maruzen Pharmaceut Co Ltd | メラニン産生抑制剤および美白用化粧料 |
JP2001261568A (ja) | 2000-03-16 | 2001-09-26 | Kanebo Ltd | プロフィラグリン及び/又はフィラグリン蛋白産生促進剤 |
JP2002201122A (ja) | 2000-10-24 | 2002-07-16 | Maruzen Pharmaceut Co Ltd | 美白化粧料 |
JP2002226323A (ja) | 2001-02-02 | 2002-08-14 | Maruzen Pharmaceut Co Ltd | コラーゲン産生促進剤、コラゲナーゼ阻害剤、線維芽細胞増殖作用剤、エラスターゼ阻害剤、エストロゲン様作用剤、皮膚化粧料並びに美容用飲食品 |
JP2002363054A (ja) | 2001-06-05 | 2002-12-18 | Maruzen Pharmaceut Co Ltd | フィラグリン合成促進剤、角質層保湿機能改善・増強剤および角質層遊離アミノ酸量増加剤 |
JP2002370962A (ja) | 2001-06-13 | 2002-12-24 | Maruzen Pharmaceut Co Ltd | 美白用化粧料および皮膚老化防止・改善用化粧料 |
JP2003012532A (ja) | 2001-07-06 | 2003-01-15 | Maruzen Pharmaceut Co Ltd | ヒアルロニダーゼ阻害剤、ヘキソサミニダーゼ遊離阻害剤、サイクリックampホスホジエステラーゼ阻害剤及び肌荒れ改善化粧料 |
JP2003055242A (ja) | 2001-08-06 | 2003-02-26 | Maruzen Pharmaceut Co Ltd | 皮膚化粧料並びに飲食品 |
JP2003081848A (ja) | 2001-09-13 | 2003-03-19 | Maruzen Pharmaceut Co Ltd | 活性酸素消去剤、該活性酸素消去剤を配合した化粧料及び飲食物 |
JP2003146837A (ja) | 2001-11-13 | 2003-05-21 | Maruzen Pharmaceut Co Ltd | 皮膚化粧料及び美容用飲食品 |
JP2003146886A (ja) | 2001-11-14 | 2003-05-21 | Noevir Co Ltd | フィラグリン合成促進剤、及び角質層保湿機能改善剤,角質層柔軟化剤,角質層遊離アミノ酸増加剤 |
JP2003176232A (ja) | 2001-12-12 | 2003-06-24 | Maruzen Pharmaceut Co Ltd | 皮膚外用剤及び飲食品 |
JP2003176230A (ja) | 2001-12-12 | 2003-06-24 | Maruzen Pharmaceut Co Ltd | コラーゲン産生促進剤、エラスターゼ阻害剤、コラゲナーゼ阻害剤及び皮膚化粧料並びに美容用飲食品 |
JP2004083488A (ja) | 2002-08-27 | 2004-03-18 | Maruzen Pharmaceut Co Ltd | 美白用化粧料及び美白用飲食品 |
JP2005029483A (ja) | 2003-07-09 | 2005-02-03 | Maruzen Pharmaceut Co Ltd | 活性酸素消去剤、並びに化粧料及び飲食物 |
JP2006321730A (ja) | 2005-05-17 | 2006-11-30 | Maruzen Pharmaceut Co Ltd | 抗酸化剤及び抗老化剤、並びに皮膚化粧料及び飲食物 |
JP2007008902A (ja) | 2005-07-04 | 2007-01-18 | Maruzen Pharmaceut Co Ltd | 抗炎症剤、抗酸化剤及び美白剤、並びに皮膚化粧料及び飲食物 |
JP2007176830A (ja) | 2005-12-27 | 2007-07-12 | Pola Chem Ind Inc | 皮膚バリア機能を向上させるための皮膚外用剤とその製造法 |
JP2007176835A (ja) | 2005-12-27 | 2007-07-12 | Pola Chem Ind Inc | 皮膚バリア機能を向上させるための皮膚外用剤とその製造法 |
JP2009184955A (ja) | 2008-02-06 | 2009-08-20 | Maruzen Pharmaceut Co Ltd | IV型コラーゲン産生促進剤、トランスグルタミナーゼ−1産生促進剤、セリンパルミトイルトランスフェラーゼ産生促進剤、アクアポリン3産生促進剤、インボルクリン産生促進剤、HMG−CoA還元酵素産生促進剤、及び、アデノシン三リン酸産生促進剤。 |
JP2009191039A (ja) | 2008-02-15 | 2009-08-27 | Maruzen Pharmaceut Co Ltd | ヒアルロン酸合成酵素3mRNA発現促進剤、アクアポリン3mRNA発現促進剤、セリンパルミトイルトランスフェラーゼmRNA発現促進剤及びラミニン5産生促進剤 |
JP2010090093A (ja) | 2008-10-10 | 2010-04-22 | Maruzen Pharmaceut Co Ltd | I型コラーゲン産生促進剤、フィラグリン産生促進剤、インボルクリン産生促進剤、及びトランスグルタミナーゼ−1産生促進剤 |
JP2011130689A (ja) | 2009-12-24 | 2011-07-07 | Kirin Kyowa Foods Co Ltd | 抗酸化能を有する調味液、その製造方法、および当該調味液を含む飲食品 |
JP2011140453A (ja) | 2010-01-06 | 2011-07-21 | Tadatoshi Karatsu | 発酵薬草乾燥物の製造方法および発酵薬草粉末 |
Non-Patent Citations (6)
Title |
---|
「프래그런스 저널」 임시 증간 No.14, p.156, 1995년 |
「프래그런스 저널」, 2006년, Vol.34, No.10, pp.19-23 |
Arch. Dermatol. Res., vol.288, pp.442-446(1996) |
J. Cell Biol., vol.156, pp.1099-1111(2002) |
일본향장품과학회지(日本香粧品科學會誌), vol.31, pp.296-301(2007) |
프래그런스 저널 임시 증간, vol.17, pp.14-19(2000) |
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TWI857919B (zh) | 2024-10-01 |
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