WO2013066438A2
(en)
|
2011-07-22 |
2013-05-10 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
WO2014163886A1
(en)
|
2013-03-12 |
2014-10-09 |
President And Fellows Of Harvard College |
Method of generating a three-dimensional nucleic acid containing matrix
|
ES2991004T3
(es)
|
2011-12-22 |
2024-12-02 |
Harvard College |
Métodos para la detección de analitos
|
GB201122458D0
(en)
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
US9637739B2
(en)
|
2012-03-20 |
2017-05-02 |
Vilnius University |
RNA-directed DNA cleavage by the Cas9-crRNA complex
|
DK2847335T3
(en)
|
2012-04-25 |
2018-08-13 |
Regeneron Pharma |
NUCLEASED MEDIUM TARGETING WITH LARGE TARGET VECTORS
|
EP3597741A1
(en)
|
2012-04-27 |
2020-01-22 |
Duke University |
Genetic correction of mutated genes
|
LT2800811T
(lt)
|
2012-05-25 |
2017-09-11 |
The Regents Of The University Of California |
Būdai ir kompozicijos, skirti tikslinės dnr modifikavimui, panaudojant adresuotą rnr, ir transkripcijos moduliavimui, panaudojant adresuotą rnr
|
US20150225734A1
(en)
|
2012-06-19 |
2015-08-13 |
Regents Of The University Of Minnesota |
Gene targeting in plants using dna viruses
|
EP3808844A1
(en)
*
|
2012-07-25 |
2021-04-21 |
The Broad Institute, Inc. |
Inducible dna binding proteins and genome perturbation tools and applications thereof
|
CN110669758A
(zh)
|
2012-10-23 |
2020-01-10 |
基因工具股份有限公司 |
用于切割靶dna 的组合物及其用途
|
PT3138912T
(pt)
*
|
2012-12-06 |
2018-12-28 |
Sigma Aldrich Co Llc |
Modificação e regulação de genoma baseado em crispr
|
US20140186843A1
(en)
|
2012-12-12 |
2014-07-03 |
Massachusetts Institute Of Technology |
Methods, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
US20140189896A1
(en)
*
|
2012-12-12 |
2014-07-03 |
Feng Zhang |
Crispr-cas component systems, methods and compositions for sequence manipulation
|
SG11201504523UA
(en)
|
2012-12-12 |
2015-07-30 |
Broad Inst Inc |
Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications
|
US8697359B1
(en)
*
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
ES2786193T3
(es)
|
2012-12-12 |
2020-10-09 |
Broad Inst Inc |
Modificación por tecnología genética y optimización de sistemas, métodos y composiciones enzimáticas mejorados para la manipulación de secuencias
|
ES2701749T3
(es)
|
2012-12-12 |
2019-02-25 |
Broad Inst Inc |
Métodos, modelos, sistemas y aparatos para identificar secuencias diana para enzimas Cas o sistemas CRISPR-Cas para secuencias diana y transmitir resultados de los mismos
|
ES2542015T3
(es)
|
2012-12-12 |
2015-07-29 |
The Broad Institute, Inc. |
Ingeniería de sistemas, métodos y composiciones de guía optimizadas para manipulación de secuencias
|
WO2014093694A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Crispr-cas nickase systems, methods and compositions for sequence manipulation in eukaryotes
|
PT2931898E
(pt)
|
2012-12-12 |
2016-06-16 |
Harvard College |
Manipulação e otimização de sistemas, métodos e composições para manipulação de sequências com domínios funcionais
|
CN105121641A
(zh)
|
2012-12-17 |
2015-12-02 |
哈佛大学校长及研究员协会 |
Rna-引导的人类基因组工程化
|
EP3620534B1
(en)
|
2013-03-14 |
2021-10-13 |
Caribou Biosciences, Inc. |
Crispr-cas compositions of nucleic acid-targeting nucleic acids
|
US20140273235A1
(en)
*
|
2013-03-15 |
2014-09-18 |
Regents Of The University Of Minnesota |
ENGINEERING PLANT GENOMES USING CRISPR/Cas SYSTEMS
|
US9828582B2
(en)
|
2013-03-19 |
2017-11-28 |
Duke University |
Compositions and methods for the induction and tuning of gene expression
|
CN115261411A
(zh)
*
|
2013-04-04 |
2022-11-01 |
哈佛学院校长同事会 |
利用CRISPR/Cas系统的基因组编辑的治疗性用途
|
US20160186208A1
(en)
*
|
2013-04-16 |
2016-06-30 |
Whitehead Institute For Biomedical Research |
Methods of Mutating, Modifying or Modulating Nucleic Acid in a Cell or Nonhuman Mammal
|
LT2986729T
(lt)
|
2013-04-16 |
2018-10-25 |
Regeneron Pharmaceuticals, Inc. |
Žiurkės genomo tikslinė modifikacija
|
WO2014186686A2
(en)
*
|
2013-05-17 |
2014-11-20 |
Two Blades Foundation |
Targeted mutagenesis and genome engineering in plants using rna-guided cas nucleases
|
AU2014273082B2
(en)
*
|
2013-05-29 |
2018-11-08 |
Cellectis |
A method for producing precise DNA cleavage using Cas9 nickase activity
|
IL302205A
(en)
*
|
2013-06-04 |
2023-06-01 |
Harvard College |
Rna-guided transcriptional regulation
|
US9267135B2
(en)
|
2013-06-04 |
2016-02-23 |
President And Fellows Of Harvard College |
RNA-guided transcriptional regulation
|
WO2014199358A1
(en)
|
2013-06-14 |
2014-12-18 |
Cellectis |
Methods for non-transgenic genome editing in plants
|
KR20240172759A
(ko)
|
2013-06-17 |
2024-12-10 |
더 브로드 인스티튜트, 인코퍼레이티드 |
간의 표적화 및 치료를 위한 CRISPRCas 시스템, 벡터 및 조성물의 전달 및 용도
|
CA2915795C
(en)
|
2013-06-17 |
2021-07-13 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using viral components
|
AU2014281027A1
(en)
|
2013-06-17 |
2016-01-28 |
Massachusetts Institute Of Technology |
Optimized CRISPR-Cas double nickase systems, methods and compositions for sequence manipulation
|
WO2014204727A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
ES2777217T3
(es)
|
2013-06-17 |
2020-08-04 |
Broad Inst Inc |
Suministro, modificación y optimización de sistemas de guía en tándem, métodos y composiciones para la manipulación de secuencias
|
WO2015006498A2
(en)
|
2013-07-09 |
2015-01-15 |
President And Fellows Of Harvard College |
Therapeutic uses of genome editing with crispr/cas systems
|
JP7120717B2
(ja)
*
|
2013-07-09 |
2022-08-17 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
多重rna誘導型ゲノム編集
|
US11306328B2
(en)
|
2013-07-26 |
2022-04-19 |
President And Fellows Of Harvard College |
Genome engineering
|
US9163284B2
(en)
|
2013-08-09 |
2015-10-20 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a Cas9 nuclease
|
KR102304167B1
(ko)
|
2013-08-16 |
2021-09-24 |
메사추세츠 인스티튜트 오브 테크놀로지 |
세포로의 선택적 물질 전달
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
BR112016003561B8
(pt)
|
2013-08-22 |
2022-11-01 |
Du Pont |
Método para a produção de uma modificação genética, método para a introdução de um polinucleotídeo de interesse no genoma de uma planta, método para a edição de um segundo gene em um genoma de planta e método para gerar uma planta de milho resistente ao glifosato
|
US9388430B2
(en)
|
2013-09-06 |
2016-07-12 |
President And Fellows Of Harvard College |
Cas9-recombinase fusion proteins and uses thereof
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
US9228207B2
(en)
|
2013-09-06 |
2016-01-05 |
President And Fellows Of Harvard College |
Switchable gRNAs comprising aptamers
|
TW201542816A
(zh)
|
2013-09-18 |
2015-11-16 |
Kymab Ltd |
方法、細胞與生物體
|
WO2015065964A1
(en)
|
2013-10-28 |
2015-05-07 |
The Broad Institute Inc. |
Functional genomics using crispr-cas systems, compositions, methods, screens and applications thereof
|
US10584358B2
(en)
|
2013-10-30 |
2020-03-10 |
North Carolina State University |
Compositions and methods related to a type-II CRISPR-Cas system in Lactobacillus buchneri
|
DK3066201T3
(en)
|
2013-11-07 |
2018-06-06 |
Editas Medicine Inc |
CRISPR-RELATED PROCEDURES AND COMPOSITIONS WITH LEADING GRADES
|
US10787684B2
(en)
*
|
2013-11-19 |
2020-09-29 |
President And Fellows Of Harvard College |
Large gene excision and insertion
|
CN105980568B
(zh)
|
2013-12-11 |
2019-12-03 |
瑞泽恩制药公司 |
用于靶向修饰基因组的方法和组合物
|
HUE041331T2
(hu)
|
2013-12-11 |
2019-05-28 |
Regeneron Pharma |
Módszerek és készítmények a genom célzott módosításához
|
EP3653229A1
(en)
|
2013-12-12 |
2020-05-20 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for genome editing
|
US20150166985A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting von willebrand factor point mutations
|
WO2015089486A2
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems
|
EP3080260B1
(en)
|
2013-12-12 |
2019-03-06 |
The Broad Institute, Inc. |
Crispr-cas systems and methods for altering expression of gene products, structural information and inducible modular cas enzymes
|
BR112016013520A2
(pt)
|
2013-12-12 |
2017-10-03 |
Broad Inst Inc |
Composições e métodos de uso de sistemas crispr-cas em distúrbios de repetições de nucleotídeos
|
SG10201804975PA
(en)
|
2013-12-12 |
2018-07-30 |
Broad Inst Inc |
Delivery, Use and Therapeutic Applications of the Crispr-Cas Systems and Compositions for HBV and Viral Diseases and Disorders
|
WO2015089364A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crystal structure of a crispr-cas system, and uses thereof
|
US10787654B2
(en)
|
2014-01-24 |
2020-09-29 |
North Carolina State University |
Methods and compositions for sequence guiding Cas9 targeting
|
MX375420B
(es)
|
2014-02-11 |
2025-03-06 |
The Regents Of The Univ Of Colorado A Body Corporate |
Ingenieria genetica multiplexada habilitada por crispr.
|
RU2016136977A
(ru)
|
2014-02-18 |
2018-03-20 |
Дьюк Юниверсити |
Композиции для инактивации репликации вируса и способы их получения и применения
|
ES2898460T3
(es)
|
2014-02-27 |
2022-03-07 |
Monsanto Technology Llc |
Composiciones y procedimientos para la modificación genómica dirigida al sitio
|
EP3114227B1
(en)
|
2014-03-05 |
2021-07-21 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating usher syndrome and retinitis pigmentosa
|
US11339437B2
(en)
|
2014-03-10 |
2022-05-24 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
US11141493B2
(en)
|
2014-03-10 |
2021-10-12 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
ES2745769T3
(es)
|
2014-03-10 |
2020-03-03 |
Editas Medicine Inc |
Procedimientos y composiciones relacionados con CRISPR/CAS para tratar la amaurosis congénita de Leber 10 (LCA10)
|
US11242525B2
(en)
|
2014-03-26 |
2022-02-08 |
Editas Medicine, Inc. |
CRISPR/CAS-related methods and compositions for treating sickle cell disease
|
JP2017512481A
(ja)
|
2014-04-08 |
2017-05-25 |
ノースカロライナ ステート ユニバーシティーNorth Carolina State University |
Crispr関連遺伝子を用いた、rna依存性の転写抑制のための方法および組成物
|
EP3152221A4
(en)
*
|
2014-05-20 |
2018-01-24 |
Regents of the University of Minnesota |
Method for editing a genetic sequence
|
KR101886381B1
(ko)
*
|
2014-05-28 |
2018-08-10 |
기초과학연구원 |
불활성화된 표적 특이적 뉴클레아제를 이용한 표적 dna의 분리 방법
|
EP3152319A4
(en)
|
2014-06-05 |
2017-12-27 |
Sangamo BioSciences, Inc. |
Methods and compositions for nuclease design
|
KR102374379B1
(ko)
|
2014-06-06 |
2022-03-17 |
리제너론 파마슈티칼스 인코포레이티드 |
표적화된 좌를 변형시키는 방법 및 조성물
|
WO2015191693A2
(en)
|
2014-06-10 |
2015-12-17 |
Massachusetts Institute Of Technology |
Method for gene editing
|
CN106536056B
(zh)
|
2014-06-13 |
2021-07-16 |
儿童医学中心公司 |
分离线粒体的产品和方法
|
WO2015200334A1
(en)
|
2014-06-23 |
2015-12-30 |
Regeneron Pharmaceuticals, Inc. |
Nuclease-mediated dna assembly
|
US20150376586A1
(en)
*
|
2014-06-25 |
2015-12-31 |
Caribou Biosciences, Inc. |
RNA Modification to Engineer Cas9 Activity
|
WO2015200555A2
(en)
*
|
2014-06-25 |
2015-12-30 |
Caribou Biosciences, Inc. |
Rna modification to engineer cas9 activity
|
CA3172866A1
(en)
|
2014-06-26 |
2015-12-30 |
Regeneron Pharamaceuticals, Inc. |
Methods and compositions for targeted genetic modifications and methods of use
|
AU2015288157A1
(en)
|
2014-07-11 |
2017-01-19 |
E. I. Du Pont De Nemours And Company |
Compositions and methods for producing plants resistant to glyphosate herbicide
|
US11254933B2
(en)
*
|
2014-07-14 |
2022-02-22 |
The Regents Of The University Of California |
CRISPR/Cas transcriptional modulation
|
AU2015294354B2
(en)
*
|
2014-07-21 |
2021-10-28 |
Illumina, Inc. |
Polynucleotide enrichment using CRISPR-Cas systems
|
CA2956224A1
(en)
|
2014-07-30 |
2016-02-11 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
US10280402B2
(en)
|
2014-08-06 |
2019-05-07 |
College Of Medicine Pochon Cha University Industry-Academic Cooperation Foundation |
Immune-compatible cells created by nuclease-mediated editing of genes encoding HLA
|
KR20180015731A
(ko)
*
|
2014-08-06 |
2018-02-13 |
주식회사 툴젠 |
캄필로박터 제주니 crispr/cas 시스템 유래 rgen을 이용한 유전체 교정
|
US11071289B2
(en)
|
2014-08-14 |
2021-07-27 |
Biocytogen Boston Corp |
DNA knock-in system
|
US9970030B2
(en)
|
2014-08-27 |
2018-05-15 |
Caribou Biosciences, Inc. |
Methods for increasing CAS9-mediated engineering efficiency
|
EP3633032A3
(en)
|
2014-08-28 |
2020-07-29 |
North Carolina State University |
Novel cas9 proteins and guiding features for dna targeting and genome editing
|
EP3188763B1
(en)
|
2014-09-02 |
2020-05-13 |
The Regents of The University of California |
Methods and compositions for rna-directed target dna modification
|
CN108064129A
(zh)
|
2014-09-12 |
2018-05-22 |
纳幕尔杜邦公司 |
玉米和大豆中复合性状基因座的位点特异性整合位点的产生和使用方法
|
CN104212836A
(zh)
*
|
2014-09-18 |
2014-12-17 |
东华大学 |
一种在哺乳动物细胞系中敲除mir-505的方法
|
CA2963693A1
(en)
|
2014-10-10 |
2016-04-14 |
Editas Medicine, Inc. |
Compositions and methods for promoting homology directed repair
|
CN107109487B
(zh)
|
2014-10-15 |
2022-03-04 |
赛琪科学股份有限公司 |
自动处理核酸和电泳样品制备的装置、方法和系统
|
EP3561052A1
(en)
|
2014-10-15 |
2019-10-30 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for generating or maintaining pluripotent cells
|
GB201418965D0
(zh)
|
2014-10-24 |
2014-12-10 |
Ospedale San Raffaele And Fond Telethon |
|
US11111472B2
(en)
|
2014-10-31 |
2021-09-07 |
Massachusetts Institute Of Technology |
Delivery of biomolecules to immune cells
|
EP3215623A4
(en)
|
2014-11-06 |
2018-09-26 |
President and Fellows of Harvard College |
Cells lacking b2m surface expression and methods for allogeneic administration of such cells
|
KR102424721B1
(ko)
*
|
2014-11-06 |
2022-07-25 |
이 아이 듀폰 디 네모아 앤드 캄파니 |
Rna-유도 엔도뉴클레아제의 세포 내로의 펩티드 매개성 전달
|
WO2016073990A2
(en)
*
|
2014-11-07 |
2016-05-12 |
Editas Medicine, Inc. |
Methods for improving crispr/cas-mediated genome-editing
|
KR101828933B1
(ko)
*
|
2014-11-14 |
2018-02-14 |
기초과학연구원 |
유전체에서 유전자 가위의 비표적 위치를 검출하는 방법
|
US11352666B2
(en)
|
2014-11-14 |
2022-06-07 |
Institute For Basic Science |
Method for detecting off-target sites of programmable nucleases in a genome
|
ES2731437T3
(es)
|
2014-11-21 |
2019-11-15 |
Regeneron Pharma |
Métodos y composiciones para la modificación genética dirigida mediante el uso de pares de ARN guías
|
CA2969619A1
(en)
|
2014-12-03 |
2016-06-09 |
Agilent Technologies, Inc. |
Guide rna with chemical modifications
|
CN116059378A
(zh)
|
2014-12-10 |
2023-05-05 |
明尼苏达大学董事会 |
用于治疗疾病的遗传修饰的细胞、组织和器官
|
EP3889260A1
(en)
|
2014-12-12 |
2021-10-06 |
The Broad Institute, Inc. |
Protected guide rnas (pgrnas)
|
CA2971187C
(en)
*
|
2014-12-16 |
2023-10-24 |
Danisco Us Inc. |
Fungal genome modification systems and methods of use
|
US9840702B2
(en)
*
|
2014-12-18 |
2017-12-12 |
Integrated Dna Technologies, Inc. |
CRISPR-based compositions and methods of use
|
US11326184B2
(en)
|
2014-12-19 |
2022-05-10 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for targeted genetic modification through single-step multiple targeting
|
WO2016100857A1
(en)
|
2014-12-19 |
2016-06-23 |
Regeneron Pharmaceuticals, Inc. |
Stem cells for modeling type 2 diabetes
|
US11125739B2
(en)
*
|
2015-01-12 |
2021-09-21 |
Massachusetts Institute Of Technology |
Gene editing through microfluidic delivery
|
EP3256487A4
(en)
|
2015-02-09 |
2018-07-18 |
Duke University |
Compositions and methods for epigenome editing
|
CN105985943B
(zh)
*
|
2015-03-16 |
2021-07-06 |
中国科学院遗传与发育生物学研究所 |
一种利用非遗传物质对植物基因组进行定点改造的方法
|
US20180163196A1
(en)
*
|
2015-03-20 |
2018-06-14 |
Danmarks Tekniske Universitet |
Crispr/cas9 based engineering of actinomycetal genomes
|
EP3851530A1
(en)
*
|
2015-03-26 |
2021-07-21 |
Editas Medicine, Inc. |
Crispr/cas-mediated gene conversion
|
EP3274460A1
(en)
|
2015-03-27 |
2018-01-31 |
E. I. du Pont de Nemours and Company |
Soybean u6 small nuclear rna gene promoters and their use in constitutive expression of small rna genes in plants
|
KR102648489B1
(ko)
|
2015-04-06 |
2024-03-15 |
더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 |
Crispr/cas-매개 유전자 조절을 위한 화학적으로 변형된 가이드 rna
|
CN107690480B
(zh)
|
2015-04-24 |
2022-03-22 |
爱迪塔斯医药公司 |
Cas9分子/指导rna分子复合物的评价
|
AU2016261600B2
(en)
|
2015-05-08 |
2021-09-23 |
President And Fellows Of Harvard College |
Universal donor stem cells and related methods
|
US11390884B2
(en)
|
2015-05-11 |
2022-07-19 |
Editas Medicine, Inc. |
Optimized CRISPR/cas9 systems and methods for gene editing in stem cells
|
KR101785847B1
(ko)
|
2015-05-12 |
2017-10-17 |
연세대학교 산학협력단 |
선형 이중가닥 DNA를 활용한 CRISPR/Cas9 시스템을 이용한 표적 유전체 교정
|
EP3095870A1
(en)
|
2015-05-19 |
2016-11-23 |
Kws Saat Se |
Methods for the in planta transformation of plants and manufacturing processes and products based and obtainable therefrom
|
EP4039816A1
(en)
|
2015-05-29 |
2022-08-10 |
North Carolina State University |
Methods for screening bacteria, archaea, algae, and yeast using crispr nucleic acids
|
CN108368502B
(zh)
|
2015-06-03 |
2022-03-18 |
内布拉斯加大学董事委员会 |
使用单链dna的dna编辑
|
CA2986262A1
(en)
|
2015-06-09 |
2016-12-15 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for improving transplantation
|
CN107922918B
(zh)
|
2015-06-15 |
2022-10-21 |
北卡罗来纳州立大学 |
用于有效递送核酸和基于rna的抗微生物剂的方法和组合物
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
KR102575342B1
(ko)
|
2015-06-18 |
2023-09-05 |
더 브로드 인스티튜트, 인코퍼레이티드 |
표적외 효과를 감소시키는 crispr 효소 돌연변이
|
US10648020B2
(en)
|
2015-06-18 |
2020-05-12 |
The Broad Institute, Inc. |
CRISPR enzymes and systems
|
CA2990699A1
(en)
|
2015-06-29 |
2017-01-05 |
Ionis Pharmaceuticals, Inc. |
Modified crispr rna and modified single crispr rna and uses thereof
|
EP3320082B1
(en)
|
2015-07-09 |
2023-05-24 |
Massachusetts Institute of Technology |
Delivery of materials to anucleate cells
|
JP6937740B2
(ja)
*
|
2015-07-28 |
2021-09-22 |
ダニスコ・ユーエス・インク |
ゲノム編集システムおよび使用方法
|
GB2595063B
(en)
|
2015-07-31 |
2022-03-09 |
Univ Minnesota |
Modified cells and methods of therapy
|
US9580727B1
(en)
|
2015-08-07 |
2017-02-28 |
Caribou Biosciences, Inc. |
Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides
|
WO2017027910A1
(en)
|
2015-08-14 |
2017-02-23 |
The University Of Sydney |
Connexin 45 inhibition for therapy
|
EP4345455A3
(en)
|
2015-08-25 |
2024-07-17 |
Duke University |
Compositions and methods of improving specificity in genomic engineering using rna-guided endonucleases
|
US11613759B2
(en)
|
2015-09-04 |
2023-03-28 |
Sqz Biotechnologies Company |
Intracellular delivery of biomolecules to cells comprising a cell wall
|
WO2017053312A1
(en)
*
|
2015-09-21 |
2017-03-30 |
The Regents Of The University Of California |
Compositions and methods for target nucleic acid modification
|
CA2999500A1
(en)
|
2015-09-24 |
2017-03-30 |
Editas Medicine, Inc. |
Use of exonucleases to improve crispr/cas-mediated genome editing
|
WO2017058751A1
(en)
|
2015-09-28 |
2017-04-06 |
North Carolina State University |
Methods and compositions for sequence specific antimicrobials
|
KR102107735B1
(ko)
|
2015-10-06 |
2020-05-11 |
기초과학연구원 |
식물 원형질체로부터 식물체를 제조하는 방법
|
EP3362571A4
(en)
|
2015-10-13 |
2019-07-10 |
Duke University |
GENOM ENGINEERING WITH TYPE I CRISPR SYSTEMS IN EUKARYOTIC CELLS
|
MX2018004808A
(es)
*
|
2015-10-20 |
2018-08-01 |
Pioneer Hi Bred Int |
Funcion restauradora para un producto genico no funcional mediante sistemas cas guiados y metodos de uso.
|
JP7067793B2
(ja)
|
2015-10-23 |
2022-05-16 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
核酸塩基編集因子およびその使用
|
US9677090B2
(en)
|
2015-10-23 |
2017-06-13 |
Caribou Biosciences, Inc. |
Engineered nucleic-acid targeting nucleic acids
|
JP6882282B2
(ja)
|
2015-11-03 |
2021-06-02 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
三次元核酸含有マトリックスの立体撮像のための方法と装置
|
KR101885901B1
(ko)
|
2015-11-13 |
2018-08-07 |
기초과학연구원 |
5' 말단의 인산기가 제거된 rna를 포함하는 리보핵산단백질 전달용 조성물
|
JP7054678B2
(ja)
*
|
2015-11-20 |
2022-04-14 |
ワシントン・ユニバーシティ |
ゲノムdna断片の標的化された精製のための調製用電気泳動方法
|
CN106811479B
(zh)
*
|
2015-11-30 |
2019-10-25 |
中国农业科学院作物科学研究所 |
利用CRISPR/Cas9系统定点修饰ALS基因获得抗除草剂水稻的系统及其应用
|
CN108779466B
(zh)
|
2015-11-30 |
2024-03-29 |
杜克大学 |
用于通过基因编辑修正人肌营养不良蛋白基因的治疗靶标和使用方法
|
US11903975B2
(en)
|
2015-11-30 |
2024-02-20 |
Flagship Pioneering Innovations V, Inc. |
Methods and compositions relating to chondrisomes from blood products
|
JP6707133B2
(ja)
|
2015-12-04 |
2020-06-10 |
カリブー・バイオサイエンシーズ・インコーポレイテッド |
操作された核酸標的化核酸
|
CN106845151B
(zh)
*
|
2015-12-07 |
2019-03-26 |
中国农业大学 |
CRISPR-Cas9系统sgRNA作用靶点的筛选方法及装置
|
WO2017099494A1
(ko)
*
|
2015-12-08 |
2017-06-15 |
기초과학연구원 |
Cpf1을 포함하는 유전체 교정용 조성물 및 그 용도
|
US11542466B2
(en)
|
2015-12-22 |
2023-01-03 |
North Carolina State University |
Methods and compositions for delivery of CRISPR based antimicrobials
|
MY194127A
(en)
|
2016-01-11 |
2022-11-14 |
Univ Leland Stanford Junior |
Chimeric proteins and methods of immunotherapy
|
EP3402885A4
(en)
|
2016-01-11 |
2019-07-03 |
The Board of Trustees of the Leland Stanford Junior University |
CHIMERIC PROTEINS AND METHOD FOR REGULATING GENE EXPRESSION
|
SG11201805993UA
(en)
*
|
2016-01-15 |
2018-08-30 |
Jackson Lab |
Genetically modified non-human mammals by multi-cycle electroporation of cas9 protein
|
ES2927427T3
(es)
|
2016-01-15 |
2022-11-04 |
Childrens Medical Ct Corp |
Uso terapéutico de mitocondrias y agentes mitocondriales combinados
|
EP3433363A1
(en)
|
2016-03-25 |
2019-01-30 |
Editas Medicine, Inc. |
Genome editing systems comprising repair-modulating enzyme molecules and methods of their use
|
WO2017165862A1
(en)
|
2016-03-25 |
2017-09-28 |
Editas Medicine, Inc. |
Systems and methods for treating alpha 1-antitrypsin (a1at) deficiency
|
EP3436077A1
(en)
*
|
2016-03-30 |
2019-02-06 |
Intellia Therapeutics, Inc. |
Lipid nanoparticle formulations for crispr/cas components
|
WO2017180694A1
(en)
|
2016-04-13 |
2017-10-19 |
Editas Medicine, Inc. |
Cas9 fusion molecules gene editing systems, and methods of use thereof
|
JP7259182B2
(ja)
|
2016-04-25 |
2023-04-18 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
in situ分子検出のためのハイブリダイゼーション連鎖反応法
|
CN107326046A
(zh)
*
|
2016-04-28 |
2017-11-07 |
上海邦耀生物科技有限公司 |
一种提高外源基因同源重组效率的方法
|
JP7324583B2
(ja)
|
2016-05-20 |
2023-08-10 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
複数のガイドrnaを使用して免疫寛容を破綻させるための方法
|
MX2018014599A
(es)
*
|
2016-05-27 |
2019-02-28 |
Aadigen Llc |
Peptidos y nanoparticulas para suministro intracelular de moleculas editoras de genoma.
|
US10266851B2
(en)
|
2016-06-02 |
2019-04-23 |
Sigma-Aldrich Co. Llc |
Using programmable DNA binding proteins to enhance targeted genome modification
|
US10767175B2
(en)
|
2016-06-08 |
2020-09-08 |
Agilent Technologies, Inc. |
High specificity genome editing using chemically modified guide RNAs
|
EP3473728B1
(en)
*
|
2016-06-15 |
2021-10-20 |
Toolgen Incorporated |
Method for screening targeted genetic scissors by using multiple target system of on-target and off-target activity and use thereof
|
WO2017219027A1
(en)
|
2016-06-17 |
2017-12-21 |
The Broad Institute Inc. |
Type vi crispr orthologs and systems
|
US20190330603A1
(en)
*
|
2016-06-17 |
2019-10-31 |
Genesis Technologies Limited |
Crispr-cas system, materials and methods
|
FI3472325T3
(fi)
|
2016-06-20 |
2024-06-18 |
Keygene Nv |
Menetelmä kohdennettuun dna:n muuttamiseen kasvisoluissa
|
CN109688820B
(zh)
|
2016-06-24 |
2023-01-10 |
科罗拉多州立大学董事会(法人团体) |
用于生成条形码化组合文库的方法
|
US20200069818A1
(en)
*
|
2016-07-05 |
2020-03-05 |
The Johns Hopkins University |
Crispr/cas9-based compositions and methods for treating cancer
|
EP3484994A4
(en)
*
|
2016-07-13 |
2020-01-22 |
DSM IP Assets B.V. |
CRISPR-CAS-SYSTEM FOR AN ALGENE CELL
|
EP4275747A3
(en)
|
2016-07-19 |
2024-01-24 |
Duke University |
Therapeutic applications of cpf1-based genome editing
|
JP7004651B2
(ja)
*
|
2016-07-19 |
2022-02-04 |
株式会社バイオダイナミクス研究所 |
長鎖一本鎖dnaを調製する方法
|
US11123409B2
(en)
|
2016-07-28 |
2021-09-21 |
Institute For Basic Science |
Method of treating or preventing eye disease using Cas9 protein and guide RNA
|
CA3031206A1
(en)
|
2016-07-29 |
2018-02-01 |
Regeneron Pharmaceuticals, Inc. |
Fibrillin-1 mutations for modeling neonatal progeroid syndrome with congenital lipodystrophy
|
US11566263B2
(en)
|
2016-08-02 |
2023-01-31 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290 associated disease
|
GB2568182A
(en)
|
2016-08-03 |
2019-05-08 |
Harvard College |
Adenosine nucleobase editors and uses thereof
|
US11078481B1
(en)
|
2016-08-03 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for screening for cancer targets
|
EP3497214B1
(en)
|
2016-08-09 |
2023-06-28 |
President and Fellows of Harvard College |
Programmable cas9-recombinase fusion proteins and uses thereof
|
KR101710026B1
(ko)
|
2016-08-10 |
2017-02-27 |
주식회사 무진메디 |
Cas9 단백질 및 가이드 RNA의 혼성체를 함유하는 나노 리포좀 전달체 조성물
|
KR101856345B1
(ko)
*
|
2016-08-24 |
2018-06-20 |
경상대학교산학협력단 |
CRISPR/Cas9 시스템을 이용하여 APOBEC3H 및 APOBEC3CH 이중-넉아웃 고양이를 제조하는 방법
|
WO2018039438A1
(en)
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
US11078483B1
(en)
|
2016-09-02 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for measuring and improving CRISPR reagent function
|
US20190225974A1
(en)
|
2016-09-23 |
2019-07-25 |
BASF Agricultural Solutions Seed US LLC |
Targeted genome optimization in plants
|
EA201990860A1
(ru)
|
2016-09-30 |
2019-10-31 |
|
Рнк-направляемые модифицирующие нуклеиновые кислоты ферменты и способы их применения
|
US11242542B2
(en)
|
2016-10-07 |
2022-02-08 |
Integrated Dna Technologies, Inc. |
S. pyogenes Cas9 mutant genes and polypeptides encoded by same
|
KR20230164759A
(ko)
|
2016-10-07 |
2023-12-04 |
인티그레이티드 디엔에이 테크놀로지스 아이엔씨. |
S. 피오게네스 cas9 돌연변이 유전자 및 이에 의해 암호화되는 폴리펩티드
|
GB2573062A
(en)
|
2016-10-14 |
2019-10-23 |
Harvard College |
AAV delivery of nucleobase editors
|
KR101997116B1
(ko)
|
2016-10-14 |
2019-07-05 |
연세대학교 산학협력단 |
Kras 유전자에 상보적인 가이드 rna 및 이의 용도
|
GB2605883B
(en)
|
2016-10-18 |
2023-03-15 |
Univ Minnesota |
Tumor infiltrating lymphocytes and methods of therapy
|
CN109906030B
(zh)
|
2016-11-04 |
2022-03-18 |
安健基因公司 |
用于产生仅重链抗体的经基因修饰的非人动物和方法
|
EP3535416A4
(en)
|
2016-11-04 |
2020-05-13 |
Flagship Pioneering Innovations V. Inc. |
NEW PLANT CELLS, PLANTS AND SEEDS
|
JP7338937B2
(ja)
*
|
2016-11-14 |
2023-09-05 |
ツールゲン インコーポレイテッド |
人工的に操作されたsc機能制御システム
|
WO2018098383A1
(en)
|
2016-11-22 |
2018-05-31 |
Integrated Dna Technologies, Inc. |
Crispr/cpf1 systems and methods
|
WO2018111947A1
(en)
|
2016-12-12 |
2018-06-21 |
Integrated Dna Technologies, Inc. |
Genome editing enhancement
|
KR101748575B1
(ko)
*
|
2016-12-16 |
2017-06-20 |
주식회사 엠젠플러스 |
Ins 유전자 녹아웃 당뇨병 또는 당뇨병 합병증 동물모델 및 이의 제조방법
|
WO2018117377A1
(ko)
*
|
2016-12-22 |
2018-06-28 |
주식회사 툴젠 |
Fad2 유전자 조작된 올레인산 강화 식물체 및 이의 제조 방법
|
US10745677B2
(en)
|
2016-12-23 |
2020-08-18 |
President And Fellows Of Harvard College |
Editing of CCR5 receptor gene to protect against HIV infection
|
EP3561059B1
(en)
*
|
2016-12-23 |
2024-10-09 |
Institute for Basic Science |
Composition for base editing for animal embryo and base editing method
|
JP6994730B2
(ja)
*
|
2016-12-26 |
2022-02-04 |
独立行政法人酒類総合研究所 |
ゲノム編集タンパク質の直接導入による糸状菌ゲノム編集方法
|
US11859219B1
(en)
|
2016-12-30 |
2024-01-02 |
Flagship Pioneering Innovations V, Inc. |
Methods of altering a target nucleotide sequence with an RNA-guided nuclease and a single guide RNA
|
EP4095263A1
(en)
|
2017-01-06 |
2022-11-30 |
Editas Medicine, Inc. |
Methods of assessing nuclease cleavage
|
KR102515727B1
(ko)
*
|
2017-01-11 |
2023-03-30 |
주식회사 툴젠 |
중첩된 가이드핵산을 이용한 표적 핵산에 특정 핵산 서열을 삽입하기 위한 조성물 및 방법
|
BR112019014841A2
(pt)
|
2017-01-23 |
2020-04-28 |
Regeneron Pharma |
rna guia, uso do rna guia, rna antissentido, sirna ou shrna, uso do rna antissentido, do sirna ou do shrna, ácido nucleico isolado, vetor, composição, célula, e, métodos para modificar um gene hsd17b13 em uma célula, para diminuir a expressão de um gene hsd17b13 em uma célula, para modificar uma célula e para tratar um indivíduo que não é portador da variante de hsd17b13
|
CA3051585A1
(en)
|
2017-01-28 |
2018-08-02 |
Inari Agriculture, Inc. |
Novel plant cells, plants, and seeds
|
TW201839136A
(zh)
|
2017-02-06 |
2018-11-01 |
瑞士商諾華公司 |
治療血色素異常症之組合物及方法
|
EP3594339A4
(en)
*
|
2017-03-06 |
2020-12-30 |
Institute For Basic Science |
COMPOSITION CONTAINING A C2CL ENDONUCLEASE FOR DIELECTRIC CALIBRATION, AND METHOD FOR DIELECTRIC CALIBRATION USING THE SAME
|
EP3592853A1
(en)
|
2017-03-09 |
2020-01-15 |
President and Fellows of Harvard College |
Suppression of pain by gene editing
|
US11542496B2
(en)
|
2017-03-10 |
2023-01-03 |
President And Fellows Of Harvard College |
Cytosine to guanine base editor
|
WO2018170184A1
(en)
|
2017-03-14 |
2018-09-20 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
US11268082B2
(en)
|
2017-03-23 |
2022-03-08 |
President And Fellows Of Harvard College |
Nucleobase editors comprising nucleic acid programmable DNA binding proteins
|
EP3607308A1
(en)
|
2017-04-07 |
2020-02-12 |
Sage Science, Inc. |
Systems and methods for detection of genetic structural variation using integrated electrophoretic dna purification
|
WO2018189360A1
(en)
*
|
2017-04-13 |
2018-10-18 |
Cellectis |
New sequence specific reagents targeting ccr5 in primary hematopoietic cells
|
US11913015B2
(en)
|
2017-04-17 |
2024-02-27 |
University Of Maryland, College Park |
Embryonic cell cultures and methods of using the same
|
AU2018254547B2
(en)
|
2017-04-20 |
2024-06-13 |
Egenesis, Inc. |
Methods for generating genetically modified animals
|
US11499151B2
(en)
|
2017-04-28 |
2022-11-15 |
Editas Medicine, Inc. |
Methods and systems for analyzing guide RNA molecules
|
KR20220137166A
(ko)
*
|
2017-05-05 |
2022-10-11 |
상하이 블루크로스 메디컬 사이언스 인스티튜트 |
전이유전자성 마커 서열을 이용하지 않는 세포 단리 방법
|
EP3622070A2
(en)
|
2017-05-10 |
2020-03-18 |
Editas Medicine, Inc. |
Crispr/rna-guided nuclease systems and methods
|
WO2018209320A1
(en)
|
2017-05-12 |
2018-11-15 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation
|
EP3635102A1
(en)
|
2017-06-05 |
2020-04-15 |
Regeneron Pharmaceuticals, Inc. |
B4galt1 variants and uses thereof
|
CN108977442B
(zh)
*
|
2017-06-05 |
2023-01-06 |
广州市锐博生物科技有限公司 |
用于dna编辑的系统及其应用
|
CN110997908A
(zh)
|
2017-06-09 |
2020-04-10 |
爱迪塔斯医药公司 |
工程化的cas9核酸酶
|
KR20250028508A
(ko)
|
2017-06-13 |
2025-02-28 |
플래그쉽 파이어니어링 이노베이션스 브이, 인크. |
큐론을 포함하는 조성물 및 그의 용도
|
CN111344020A
(zh)
|
2017-06-15 |
2020-06-26 |
加利福尼亚大学董事会 |
靶向非病毒dna插入
|
US9982279B1
(en)
|
2017-06-23 |
2018-05-29 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
US10011849B1
(en)
|
2017-06-23 |
2018-07-03 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
CN111511375A
(zh)
|
2017-06-30 |
2020-08-07 |
因提玛生物科学公司 |
用于基因治疗的腺相关病毒载体
|
CN107488710B
(zh)
*
|
2017-07-14 |
2020-09-22 |
上海吐露港生物科技有限公司 |
一种Cas蛋白的用途及靶标核酸分子的检测方法和试剂盒
|
US11866726B2
(en)
|
2017-07-14 |
2024-01-09 |
Editas Medicine, Inc. |
Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites
|
WO2019018441A1
(en)
*
|
2017-07-17 |
2019-01-24 |
Massachusetts Institute Of Technology |
ATLAS OF HEAVY AND ILLUMINATED HEAVY BARRIER TISSUE CELLS
|
CN111801345A
(zh)
|
2017-07-28 |
2020-10-20 |
哈佛大学的校长及成员们 |
使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物
|
EP3585160A2
(en)
|
2017-07-31 |
2020-01-01 |
Regeneron Pharmaceuticals, Inc. |
Crispr reporter non-human animals and uses thereof
|
CN110891419A
(zh)
|
2017-07-31 |
2020-03-17 |
瑞泽恩制药公司 |
评价crispr/cas-诱导的与外源供体核酸的体内重组
|
JP7359753B2
(ja)
|
2017-07-31 |
2023-10-11 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
Casトランスジェニックマウスの胚性幹細胞およびマウスならびにその使用
|
CN111278848B
(zh)
|
2017-08-04 |
2023-06-27 |
北京大学 |
特异性识别甲基化修饰dna碱基的tale rvd及其应用
|
WO2019028686A1
(zh)
|
2017-08-08 |
2019-02-14 |
北京大学 |
基因敲除方法
|
WO2019139645A2
(en)
|
2017-08-30 |
2019-07-18 |
President And Fellows Of Harvard College |
High efficiency base editors comprising gam
|
US11713452B2
(en)
|
2017-09-08 |
2023-08-01 |
University Of North Texas Health Science Center |
Engineered CAS9 variants
|
JP7190096B2
(ja)
|
2017-09-18 |
2022-12-15 |
博雅▲緝▼因(北京)生物科技有限公司 |
遺伝子編集t細胞及びその使用
|
BR112020006428A2
(pt)
*
|
2017-09-28 |
2020-09-24 |
Toolgen Incorporated |
manipulação de genoma artificial para regulação de expressão de genes
|
US11572574B2
(en)
|
2017-09-28 |
2023-02-07 |
Toolgen Incorporated |
Artificial genome manipulation for gene expression regulation
|
KR102207352B1
(ko)
*
|
2017-09-29 |
2021-01-26 |
서울대학교산학협력단 |
Klotho 유전자 넉아웃 질환모델 동물 및 이의 용도
|
AU2018339089A1
(en)
*
|
2017-09-29 |
2020-04-09 |
Intellia Therapeutics, Inc. |
Polynucleotides, compositions, and methods for genome editing
|
CN111163633B
(zh)
|
2017-09-29 |
2022-09-09 |
瑞泽恩制药公司 |
包含人源化ttr基因座的非人类动物及其使用方法
|
EP3697906A1
(en)
|
2017-10-16 |
2020-08-26 |
The Broad Institute, Inc. |
Uses of adenosine base editors
|
MX2020004325A
(es)
|
2017-10-27 |
2020-11-09 |
Univ California |
Reemplazo dirigido de receptores de células t endógenos.
|
CN109722414A
(zh)
|
2017-10-27 |
2019-05-07 |
博雅辑因(北京)生物科技有限公司 |
一种高效制备成熟红细胞的方法以及用于制备成熟红细胞的培养基
|
WO2019089804A1
(en)
|
2017-11-01 |
2019-05-09 |
The Regents Of The University Of California |
Casy compositions and methods of use
|
CN108192956B
(zh)
*
|
2017-11-17 |
2021-06-01 |
东南大学 |
一种基于Cas9核酸酶的DNA检测分析方法及其应用
|
WO2019103442A2
(ko)
|
2017-11-21 |
2019-05-31 |
한국생명공학연구원 |
CRISPR/Cpf1 시스템을 이용한 유전체 편집용 조성물 및 이의 용도
|
US20200362366A1
(en)
|
2018-01-12 |
2020-11-19 |
Basf Se |
Gene underlying the number of spikelets per spike qtl in wheat on chromosome 7a
|
EP3744844A4
(en)
*
|
2018-01-23 |
2021-10-20 |
Institute for Basic Science |
EXTENDED SIMPLE RNA GUIDE AND ASSOCIATED USE
|
US11926835B1
(en)
|
2018-01-29 |
2024-03-12 |
Inari Agriculture Technology, Inc. |
Methods for efficient tomato genome editing
|
WO2019156475A1
(ko)
*
|
2018-02-06 |
2019-08-15 |
주식회사 진씨커 |
돌연변이 세포 유리 유전자 분리 키트 및 이를 이용한 돌연변이 세포 유리 유전자 분리 방법
|
KR102086689B1
(ko)
|
2018-02-06 |
2020-03-09 |
주식회사 진씨커 |
돌연변이 세포 유리 유전자 분리 키트 및 이를 이용한 돌연변이 세포 유리 유전자 분리 방법
|
KR20200124702A
(ko)
|
2018-02-23 |
2020-11-03 |
파이어니어 하이 부렛드 인터내쇼날 인코포레이팃드 |
신규한 cas9 오르소로그
|
WO2019178426A1
(en)
|
2018-03-14 |
2019-09-19 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
EP3592140A1
(en)
|
2018-03-19 |
2020-01-15 |
Regeneron Pharmaceuticals, Inc. |
Transcription modulation in animals using crispr/cas systems
|
MX2020010974A
(es)
|
2018-04-19 |
2021-01-20 |
Univ California |
Composiciones y métodos para la edición de genes.
|
WO2019206233A1
(zh)
*
|
2018-04-25 |
2019-10-31 |
中国农业大学 |
一种RNA编辑的CRISPR/Cas效应蛋白及系统
|
CN112654710A
(zh)
|
2018-05-16 |
2021-04-13 |
辛瑟高公司 |
用于指导rna设计和使用的方法和系统
|
EP3797160A1
(en)
|
2018-05-23 |
2021-03-31 |
The Broad Institute Inc. |
Base editors and uses thereof
|
US11866719B1
(en)
|
2018-06-04 |
2024-01-09 |
Inari Agriculture Technology, Inc. |
Heterologous integration of regulatory elements to alter gene expression in wheat cells and wheat plants
|
KR102035654B1
(ko)
*
|
2018-07-23 |
2019-10-24 |
대한민국 |
항균 펩타이드를 생산하는 돌연변이 곤충 세포주 또는 이의 제조방법
|
US11479762B1
(en)
|
2018-08-31 |
2022-10-25 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
AU2019341000B2
(en)
*
|
2018-09-12 |
2023-03-16 |
Institute For Basic Science |
Composition for inducing death of cells having mutated gene, and method for inducing death of cells having modified gene by using composition
|
EP3861120A4
(en)
|
2018-10-01 |
2023-08-16 |
North Carolina State University |
Recombinant type i crispr-cas system
|
US12203123B2
(en)
|
2018-10-01 |
2025-01-21 |
North Carolina State University |
Recombinant type I CRISPR-Cas system and uses thereof for screening for variant cells
|
WO2020076976A1
(en)
|
2018-10-10 |
2020-04-16 |
Readcoor, Inc. |
Three-dimensional spatial molecular indexing
|
KR102081962B1
(ko)
*
|
2018-10-11 |
2020-02-26 |
충남대학교 산학협력단 |
아밀로이드 전구 단백질 유전자를 절단하기 위한 조성물
|
CN113272428A
(zh)
|
2018-10-18 |
2021-08-17 |
英特利亚治疗股份有限公司 |
核酸构建体和使用方法
|
CN114207130A
(zh)
|
2018-10-18 |
2022-03-18 |
英特利亚治疗股份有限公司 |
用于从白蛋白基因座进行转基因表达的组合物和方法
|
CN113260701A
(zh)
|
2018-10-18 |
2021-08-13 |
英特利亚治疗股份有限公司 |
用于表达因子ix的组合物和方法
|
CN113195721A
(zh)
|
2018-10-18 |
2021-07-30 |
英特利亚治疗股份有限公司 |
治疗α-1抗胰蛋白酶缺乏症的组合物和方法
|
WO2020088450A1
(zh)
*
|
2018-10-29 |
2020-05-07 |
中国农业大学 |
新型CRISPR/Cas12f酶和系统
|
US20220010321A1
(en)
*
|
2018-11-01 |
2022-01-13 |
Keygene N.V. |
Dual guide rna for crispr/cas genome editing in plants cells
|
EP3650557B1
(en)
*
|
2018-11-07 |
2021-10-20 |
Justus-Liebig-Universität Gießen |
Method for determination of restriction efficiency of endonucleases mediating double-strand breaks in dna target sequences
|
EP3882347A4
(en)
*
|
2018-11-16 |
2022-03-02 |
Osaka University |
METHODS FOR GENERATING GENOMEEDIT CELLS
|
KR20200071198A
(ko)
|
2018-12-10 |
2020-06-19 |
네오이뮨텍, 인코퍼레이티드 |
Nrf2 발현 조절 기반 T 세포 항암면역치료법
|
CN113423823A
(zh)
*
|
2018-12-12 |
2021-09-21 |
国立大学法人九州大学 |
经基因组编辑的细胞的制造方法
|
US11166996B2
(en)
|
2018-12-12 |
2021-11-09 |
Flagship Pioneering Innovations V, Inc. |
Anellovirus compositions and methods of use
|
CA3117228A1
(en)
|
2018-12-14 |
2020-06-18 |
Pioneer Hi-Bred International, Inc. |
Novel crispr-cas systems for genome editing
|
EP3732291A1
(en)
|
2018-12-20 |
2020-11-04 |
Regeneron Pharmaceuticals, Inc. |
Nuclease-mediated repeat expansion
|
GB2596660B
(en)
*
|
2019-01-07 |
2023-09-13 |
Crisp Hr Therapeutics Inc |
A non-toxic Cas9 enzyme and application thereof
|
CN109868275A
(zh)
*
|
2019-03-12 |
2019-06-11 |
中国农业大学 |
CRISPR/Cas9介导的羊FGF5基因敲除和定点整合MTNR1A基因的方法
|
IL286357B2
(en)
|
2019-03-18 |
2024-10-01 |
Regeneron Pharma |
Crispr/cas screening platform to identify genetic modifiers of tau seeding or aggregation
|
CA3127814C
(en)
|
2019-03-18 |
2024-05-14 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas dropout screening platform to reveal genetic vulnerabilities associated with tau aggregation
|
WO2020191248A1
(en)
|
2019-03-19 |
2020-09-24 |
The Broad Institute, Inc. |
Method and compositions for editing nucleotide sequences
|
AU2020256225B2
(en)
|
2019-04-03 |
2025-03-27 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for insertion of antibody coding sequences into a safe harbor locus
|
CA3133359C
(en)
|
2019-04-04 |
2023-04-11 |
Regeneron Pharmaceuticals, Inc. |
Methods for scarless introduction of targeted modifications into targeting vectors
|
AU2020253532B2
(en)
|
2019-04-04 |
2024-06-20 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized coagulation factor 12 locus
|
CR20210591A
(es)
|
2019-04-30 |
2022-03-11 |
Edigene Inc |
Método para la predicción de eficacia del tratamiento de hemoglobinopatía
|
US11692197B2
(en)
|
2019-05-06 |
2023-07-04 |
Inari Agriculture Technology, Inc. |
Delivery of biological molecules to plant cells
|
CN111304180B
(zh)
*
|
2019-06-04 |
2023-05-26 |
山东舜丰生物科技有限公司 |
一种新的dna核酸切割酶及其应用
|
CN113874510A
(zh)
|
2019-06-04 |
2021-12-31 |
瑞泽恩制药公司 |
包括具有β滑移突变的人源化TTR基因座的非人动物和使用方法
|
BR112021022722A2
(pt)
|
2019-06-07 |
2022-01-04 |
Regeneron Pharma |
Animal não humano, célula de animal não humana, genoma de animal não humano, gene de albumina animal não humana humanizada, vetor de alvejamento, método de avaliação da atividade de um reagente, e, método de otimização da atividade de um reagente
|
CA3137765A1
(en)
|
2019-06-14 |
2020-12-17 |
Regeneron Pharmaceuticals, Inc. |
Models of tauopathy
|
MX2021014861A
(es)
|
2019-06-25 |
2022-06-22 |
Inari Agriculture Tech Inc |
Edicion genomica de reparacion dependiente de homologia mejorada.
|
CN115244176A
(zh)
*
|
2019-08-19 |
2022-10-25 |
钟明宏 |
向导rna-cas蛋白复合物的缀合物
|
WO2021043278A1
(zh)
|
2019-09-04 |
2021-03-11 |
博雅辑因(北京)生物科技有限公司 |
基于脱靶评估评价基因编辑治疗的方法
|
EP4028063A1
(en)
|
2019-09-13 |
2022-07-20 |
Regeneron Pharmaceuticals, Inc. |
Transcription modulation in animals using crispr/cas systems delivered by lipid nanoparticles
|
CA3147643A1
(en)
|
2019-09-23 |
2021-04-01 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating hepatocyte nuclear factor 4-alpha (hnf4.alpha.) gene expression
|
AU2020355000A1
(en)
|
2019-09-23 |
2022-03-17 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating apolipoprotein B (APOB) gene expression
|
WO2021067788A1
(en)
|
2019-10-03 |
2021-04-08 |
Artisan Development Labs, Inc. |
Crispr systems with engineered dual guide nucleic acids
|
CN114901302A
(zh)
*
|
2019-11-05 |
2022-08-12 |
成对植物服务股份有限公司 |
Rna编码的dna置换等位基因的组合物和方法
|
KR20220097414A
(ko)
|
2019-11-08 |
2022-07-07 |
리제너론 파마슈티칼스 인코포레이티드 |
X-연관 연소 망막층간분리 치료법을 위한 crispr 및 aav 전략
|
JP7448120B2
(ja)
*
|
2019-11-14 |
2024-03-12 |
国立研究開発法人農業・食品産業技術総合研究機構 |
プラズマを用いてゲノム編集酵素を植物細胞内に導入する方法
|
WO2021108363A1
(en)
|
2019-11-25 |
2021-06-03 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas-mediated upregulation of humanized ttr allele
|
WO2021108442A2
(en)
*
|
2019-11-27 |
2021-06-03 |
The Regents Of The University Of California |
Modulators of cas9 polypeptide activity and methods of use thereof
|
WO2021136415A1
(zh)
|
2019-12-30 |
2021-07-08 |
博雅辑因(北京)生物科技有限公司 |
一种纯化ucart细胞的方法与应用
|
JP2023509058A
(ja)
|
2019-12-30 |
2023-03-06 |
博雅▲緝▼因(北京)生物科技有限公司 |
T細胞リンパ腫細胞を標的とするユニバーサルcar-tならびにその調製方法及び使用
|
US20230053781A1
(en)
|
2020-01-14 |
2023-02-23 |
Toolgen Incorporated |
Pharmaceutical composition for preventing or treating alzheimer's and use thereof
|
JP7642651B2
(ja)
*
|
2020-01-14 |
2025-03-10 |
ツールゲン インコーポレイテッド |
低酸素環境下で高い適応力を有する細胞及びその用途
|
WO2021163515A1
(en)
*
|
2020-02-12 |
2021-08-19 |
Temple University - Of The Commonwealth System Of Higher Education |
Crispr-cas9 mediated disruption of alcam gene inhibits adhesion and trans-endothelial migration of myeloid cells
|
KR20210109384A
(ko)
|
2020-02-27 |
2021-09-06 |
주식회사 엘지화학 |
원형질체를 활용한 식물 유전자 교정 효율 증대 방법
|
EP4114946A1
(en)
|
2020-03-04 |
2023-01-11 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for sensitization of tumor cells to immune therapy
|
CN116096886A
(zh)
|
2020-03-11 |
2023-05-09 |
欧米茄治疗公司 |
用于调节叉头框p3(foxp3)基因表达的组合物和方法
|
WO2021195079A1
(en)
|
2020-03-23 |
2021-09-30 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized ttr locus comprising a v30m mutation and methods of use
|
US12057197B2
(en)
|
2020-04-03 |
2024-08-06 |
Creyon Bio, Inc. |
Oligonucleotide-based machine learning
|
EP4146804A1
(en)
|
2020-05-08 |
2023-03-15 |
The Broad Institute Inc. |
Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence
|
CN111690720B
(zh)
*
|
2020-06-16 |
2021-06-15 |
山东舜丰生物科技有限公司 |
利用修饰的单链核酸进行靶核酸检测的方法
|
US20220049303A1
(en)
|
2020-08-17 |
2022-02-17 |
Readcoor, Llc |
Methods and systems for spatial mapping of genetic variants
|
EP4256052A1
(en)
|
2020-12-02 |
2023-10-11 |
Decibel Therapeutics, Inc. |
Crispr sam biosensor cell lines and methods of use thereof
|
WO2022124839A1
(ko)
*
|
2020-12-09 |
2022-06-16 |
재단법인 아산사회복지재단 |
온-타겟 활성이 유지되고 오프-타겟 활성이 감소된 가이드 rna 및 이의 용도
|
JP2024501287A
(ja)
|
2020-12-23 |
2024-01-11 |
フラッグシップ パイオニアリング イノベーションズ ブイ, インコーポレイテッド |
RNAを閉じ込めたアネロウイルス(Anellovirus)キャプシドのインビトロアセンブリ
|
WO2022147133A1
(en)
|
2020-12-30 |
2022-07-07 |
Intellia Therapeutics, Inc. |
Engineered t cells
|
KR102285906B1
(ko)
*
|
2021-02-18 |
2021-08-04 |
주식회사 엔에이피 |
수생태계 교란어종 관리를 위한 큰입배스 불임 유도용 조성물
|
WO2022240846A1
(en)
|
2021-05-10 |
2022-11-17 |
Sqz Biotechnologies Company |
Methods for delivering genome editing molecules to the nucleus or cytosol of a cell and uses thereof
|
KR102616916B1
(ko)
*
|
2021-05-11 |
2023-12-21 |
주식회사 애이마 |
발암성 돌연변이 유전자 검출용 가이드 rna 내지 이의 용도
|
WO2022251644A1
(en)
|
2021-05-28 |
2022-12-01 |
Lyell Immunopharma, Inc. |
Nr4a3-deficient immune cells and uses thereof
|
EP4419672A2
(en)
|
2021-06-01 |
2024-08-28 |
Artisan Development Labs, Inc. |
Compositions and methods for targeting, editing, or modifying genes
|
KR20240027676A
(ko)
|
2021-06-02 |
2024-03-04 |
라이엘 이뮤노파마, 인크. |
Nr4a3-결핍 면역 세포 및 이의 용도
|
KR102618072B1
(ko)
|
2021-06-15 |
2023-12-28 |
대한민국 |
작물의 개화조절 관련 유전자 교정용 가이드 rna 및 이의 용도
|
WO2022266538A2
(en)
|
2021-06-18 |
2022-12-22 |
Artisan Development Labs, Inc. |
Compositions and methods for targeting, editing or modifying human genes
|
EP4367242A2
(en)
|
2021-07-07 |
2024-05-15 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating secreted frizzled receptor protein 1 (sfrp1) gene expression
|
EP4368703A1
(en)
|
2021-07-09 |
2024-05-15 |
Toolgen Incorporated |
Mesenchymal stem cell having oxidative stress resistance, preparation method therefor, and use thereof
|
CN117730144A
(zh)
|
2021-07-29 |
2024-03-19 |
株式会社图尔金 |
具有血液相容性的间充质干细胞、其制备方法及用途
|
CN113584134B
(zh)
*
|
2021-09-06 |
2024-01-30 |
青岛金斯达生物技术有限公司 |
一种基于CRISPR-Cas9的等温核酸检测系统及其方法和应用
|
WO2023039586A1
(en)
|
2021-09-10 |
2023-03-16 |
Agilent Technologies, Inc. |
Guide rnas with chemical modification for prime editing
|
JP2024537991A
(ja)
|
2021-10-14 |
2024-10-18 |
アーセナル バイオサイエンシズ インコーポレイテッド |
共発現されるshRNAと論理ゲートシステムとを有する免疫細胞
|
CN118119702A
(zh)
|
2021-10-14 |
2024-05-31 |
隆萨销售股份有限公司 |
用于细胞外囊泡产生的经修饰的生产者细胞
|
WO2023077053A2
(en)
|
2021-10-28 |
2023-05-04 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas-related methods and compositions for knocking out c5
|
MX2024005318A
(es)
|
2021-11-01 |
2024-09-23 |
Tome Biosciences Inc |
Plataforma de construccion unica para el suministro simultaneo de maquinaria de edicion de genes y carga de acido nucleico.
|
IL312971A
(en)
|
2021-12-08 |
2024-07-01 |
Regeneron Pharma |
Mutant myocilin disease model and uses thereof
|
EP4452335A1
(en)
|
2021-12-22 |
2024-10-30 |
Tome Biosciences, Inc. |
Co-delivery of a gene editor construct and a donor template
|
AU2022417615A1
(en)
|
2021-12-23 |
2024-06-27 |
University Of Massachusetts |
Therapeutic treatment for fragile x-associated disorder
|
AU2022424002A1
(en)
|
2021-12-29 |
2024-06-13 |
Bristol-Myers Squibb Company |
Generation of landing pad cell lines
|
WO2023150181A1
(en)
|
2022-02-01 |
2023-08-10 |
President And Fellows Of Harvard College |
Methods and compositions for treating cancer
|
KR20240135629A
(ko)
|
2022-02-02 |
2024-09-11 |
리제너론 파마슈티칼스 인코포레이티드 |
폼페병의 치료를 위한 항-TfR:GAA 및 항-CD63:GAA 삽입
|
WO2023167882A1
(en)
|
2022-03-01 |
2023-09-07 |
Artisan Development Labs, Inc. |
Composition and methods for transgene insertion
|
JP2025506976A
(ja)
|
2022-03-04 |
2025-03-13 |
ツールゲン インコーポレイテッド |
低免疫原性幹細胞、幹細胞から分化または由来した低免疫原性細胞およびこの製造方法
|
CN114410609B
(zh)
*
|
2022-03-29 |
2022-07-12 |
舜丰生物科技(海南)有限公司 |
一种活性提高的Cas蛋白以及应用
|
WO2023205744A1
(en)
|
2022-04-20 |
2023-10-26 |
Tome Biosciences, Inc. |
Programmable gene insertion compositions
|
WO2023205844A1
(en)
*
|
2022-04-26 |
2023-11-02 |
Peter Maccallum Cancer Institute |
Nucleic acids and uses thereof
|
CN119487200A
(zh)
|
2022-04-29 |
2025-02-18 |
瑞泽恩制药公司 |
用于基因治疗方法的组织特异性基因外安全港的鉴定
|
WO2023215831A1
(en)
|
2022-05-04 |
2023-11-09 |
Tome Biosciences, Inc. |
Guide rna compositions for programmable gene insertion
|
WO2023220603A1
(en)
|
2022-05-09 |
2023-11-16 |
Regeneron Pharmaceuticals, Inc. |
Vectors and methods for in vivo antibody production
|
CN119183473A
(zh)
|
2022-05-13 |
2024-12-24 |
株式会社图尔金 |
具有血液相容性的血管内移植用细胞、其制备方法及用途
|
EP4525892A1
(en)
|
2022-05-19 |
2025-03-26 |
Lyell Immunopharma, Inc. |
Polynucleotides targeting nr4a3 and uses thereof
|
WO2023225670A2
(en)
|
2022-05-20 |
2023-11-23 |
Tome Biosciences, Inc. |
Ex vivo programmable gene insertion
|
WO2023225410A2
(en)
|
2022-05-20 |
2023-11-23 |
Artisan Development Labs, Inc. |
Systems and methods for assessing risk of genome editing events
|
AU2023276715A1
(en)
|
2022-05-25 |
2025-01-09 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and methods for modulating circulating factors
|
WO2023230566A2
(en)
|
2022-05-25 |
2023-11-30 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and methods for modulating cytokines
|
WO2023230570A2
(en)
|
2022-05-25 |
2023-11-30 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and methods for modulating genetic drivers
|
KR20250019772A
(ko)
|
2022-05-25 |
2025-02-11 |
플래그쉽 파이어니어링 이노베이션스 Vii, 엘엘씨 |
종양 억제인자 및 발암유전자를 조절하기 위한 조성물 및 방법
|
CN119563038A
(zh)
|
2022-05-25 |
2025-03-04 |
旗舰创业创新七公司 |
用于调节免疫应答的组合物和方法
|
CN119421951A
(zh)
|
2022-05-31 |
2025-02-11 |
瑞泽恩制药公司 |
用于c9orf72重复序列扩增疾病的crispr干扰疗法
|
WO2023235725A2
(en)
|
2022-05-31 |
2023-12-07 |
Regeneron Pharmaceuticals, Inc. |
Crispr-based therapeutics for c9orf72 repeat expansion disease
|
IL317874A
(en)
|
2022-06-24 |
2025-02-01 |
Tune Therapeutics Inc |
Compounds, systems and methods for reducing low density lipoproteins through targeted gene suppression
|
CN119585419A
(zh)
|
2022-06-29 |
2025-03-07 |
因特利亚治疗公司 |
工程化t细胞
|
EP4299733A1
(en)
|
2022-06-30 |
2024-01-03 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
WO2024005863A1
(en)
|
2022-06-30 |
2024-01-04 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
WO2024005864A1
(en)
|
2022-06-30 |
2024-01-04 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
EP4299739A1
(en)
|
2022-06-30 |
2024-01-03 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
WO2024020587A2
(en)
|
2022-07-22 |
2024-01-25 |
Tome Biosciences, Inc. |
Pleiopluripotent stem cell programmable gene insertion
|
WO2024026474A1
(en)
|
2022-07-29 |
2024-02-01 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle
|
IL318553A
(en)
|
2022-08-05 |
2025-03-01 |
Regeneron Pharma |
Aggregation-resistant TDP-43 variants
|
CN115386597A
(zh)
*
|
2022-09-19 |
2022-11-25 |
国家纳米科学中心 |
一种提高基因载体转染效率和/或转染精度的转染辅助试剂及其应用
|
WO2024064958A1
(en)
|
2022-09-23 |
2024-03-28 |
Lyell Immunopharma, Inc. |
Methods for culturing nr4a-deficient cells
|
WO2024064952A1
(en)
|
2022-09-23 |
2024-03-28 |
Lyell Immunopharma, Inc. |
Methods for culturing nr4a-deficient cells overexpressing c-jun
|
WO2024073606A1
(en)
|
2022-09-28 |
2024-04-04 |
Regeneron Pharmaceuticals, Inc. |
Antibody resistant modified receptors to enhance cell-based therapies
|
WO2024077174A1
(en)
|
2022-10-05 |
2024-04-11 |
Lyell Immunopharma, Inc. |
Methods for culturing nr4a-deficient cells
|
US20240182561A1
(en)
|
2022-11-04 |
2024-06-06 |
Regeneron Pharmaceuticals, Inc. |
Calcium voltage-gated channel auxiliary subunit gamma 1 (cacng1) binding proteins and cacng1-mediated delivery to skeletal muscle
|
WO2024102434A1
(en)
|
2022-11-10 |
2024-05-16 |
Senda Biosciences, Inc. |
Rna compositions comprising lipid nanoparticles or lipid reconstructed natural messenger packs
|
US20240173426A1
(en)
|
2022-11-14 |
2024-05-30 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes
|
WO2024138194A1
(en)
|
2022-12-22 |
2024-06-27 |
Tome Biosciences, Inc. |
Platforms, compositions, and methods for in vivo programmable gene insertion
|
WO2024159071A1
(en)
|
2023-01-27 |
2024-08-02 |
Regeneron Pharmaceuticals, Inc. |
Modified rhabdovirus glycoproteins and uses thereof
|
WO2024211287A1
(en)
|
2023-04-03 |
2024-10-10 |
Seagen Inc. |
Production cell lines with targeted integration sites
|
WO2024218295A1
(en)
|
2023-04-21 |
2024-10-24 |
Vib Vzw |
Allelic combinations in crops for yield increase
|
WO2024234006A1
(en)
|
2023-05-11 |
2024-11-14 |
Tome Biosciences, Inc. |
Systems, compositions, and methods for targeting liver sinusodial endothelial cells (lsecs)
|
WO2024243438A2
(en)
|
2023-05-23 |
2024-11-28 |
Omega Therapeutics, Inc. |
Compositions and methods for reducing cxcl9, cxcl10, and cxcl11 gene expression
|
WO2024259309A1
(en)
|
2023-06-15 |
2024-12-19 |
Regeneron Pharmaceuticals, Inc. |
Gene therapy for hearing disorders
|
WO2025006963A1
(en)
|
2023-06-30 |
2025-01-02 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for increasing homology-directed repair
|
WO2025029662A1
(en)
|
2023-07-28 |
2025-02-06 |
Regeneron Pharmaceuticals, Inc. |
Anti-tfr: acid sphingomyelinase for treatment of acid sphingomyelinase deficiency
|
WO2025029654A2
(en)
|
2023-07-28 |
2025-02-06 |
Regeneron Pharmaceuticals, Inc. |
Use of bgh-sv40l tandem polya to enhance transgene expression during unidirectional gene insertion
|
WO2025029657A2
(en)
|
2023-07-28 |
2025-02-06 |
Regeneron Pharmaceuticals, Inc. |
Anti-tfr:gaa and anti-cd63:gaa insertion for treatment of pompe disease
|
WO2025038750A2
(en)
|
2023-08-14 |
2025-02-20 |
President And Fellows Of Harvard College |
Methods and compositions for treating cancer
|
WO2025038164A1
(en)
*
|
2023-08-15 |
2025-02-20 |
University Of Massachusetts |
Nick resection in cancer
|
WO2025049524A1
(en)
|
2023-08-28 |
2025-03-06 |
Regeneron Pharmaceuticals, Inc. |
Cxcr4 antibody-resistant modified receptors
|
WO2025050069A1
(en)
|
2023-09-01 |
2025-03-06 |
Tome Biosciences, Inc. |
Programmable gene insertion using engineered integration enzymes
|
WO2025056732A1
(en)
|
2023-09-13 |
2025-03-20 |
Medizinische Universität Graz |
Method for providing antigen-reactive lymphocytes
|