DE60225478D1 - Verfahren zur herstellung des coenzyms q10 - Google Patents

Verfahren zur herstellung des coenzyms q10

Info

Publication number: DE60225478D1
Authority: DE; Germany
Prior art keywords: coenzyme; reduced coenzyme; recovering; present; microbial cells
Prior art date: 2001-12-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60225478T

Other languages

English (en)

Other versions

DE60225478C5 (de

DE60225478T2 (de

Inventor

Kazuyoshi Yajima

Takahisa Kato

Akihisa Kanda

Shiro Kitamura

Yasuyoshi Ueda

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Kaneka Corp

Original Assignee

Kaneka Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-27

Filing date

2002-12-27

Publication date

2008-04-17

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=19189359&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60225478(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-12-27 Application filed by Kaneka Corp filed Critical Kaneka Corp

2008-04-17 Application granted granted Critical

2008-04-17 Publication of DE60225478D1 publication Critical patent/DE60225478D1/de

2009-02-26 Publication of DE60225478T2 publication Critical patent/DE60225478T2/de

2015-09-17 Publication of DE60225478C5 publication Critical patent/DE60225478C5/de

2022-12-28 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/66—Preparation of oxygen-containing organic compounds containing the quinoid structure

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Life Sciences & Earth Sciences (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Biotechnology (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DE60225478.7T 2001-12-27 2002-12-27 Verfahren zur herstellung des coenzyms q10 Expired - Lifetime DE60225478C5 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP2001398545		2001-12-27
JP2001398545		2001-12-27
PCT/JP2002/013766 WO2003056024A1 (fr)	2001-12-27	2002-12-27	Procedes de production de la co-enzyme q10

Publications (3)

Publication Number	Publication Date
DE60225478D1 true DE60225478D1 (de)	2008-04-17
DE60225478T2 DE60225478T2 (de)	2009-02-26
DE60225478C5 DE60225478C5 (de)	2015-09-17

Family

ID=19189359

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60225478.7T Expired - Lifetime DE60225478C5 (de)	2001-12-27	2002-12-27	Verfahren zur herstellung des coenzyms q10

Country Status (12)

Country	Link
US (4)	US20050069996A1 (de)
EP (1)	EP1466983B1 (de)
JP (4)	JP4256782B2 (de)
KR (1)	KR100913464B1 (de)
CN (1)	CN100523205C (de)
AT (1)	ATE388236T1 (de)
AU (1)	AU2002357526B2 (de)
CA (1)	CA2471763C (de)
DE (1)	DE60225478C5 (de)
RU (1)	RU2298035C2 (de)
TW (2)	TWI305547B (de)
WO (1)	WO2003056024A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI305547B (en)	2001-12-27	2009-01-21	Kaneka Corp	Processes for producing coenzyme q10
TW200302055A (en) *	2002-01-18	2003-08-01	Kaneka Corp	Ubiquinol-enriched fat-containing foods
JP4426832B2 (ja)	2002-12-03	2010-03-03	株式会社分子生理化学研究所	コエンザイムｑ−１０及びその２電子還元体の分析方法
WO2006092449A2 (en)	2005-03-02	2006-09-08	Metanomics Gmbh	Process for the production of fine chemicals
EP2025662A4 (de) *	2006-04-28	2011-07-27	Kaneka Corp	Verfahren zur aufreinigung von reduziertem coenzym q10
KR101406044B1 (ko) *	2007-06-08	2014-06-12	한국생산기술연구원	감귤박을 탄소원으로 첨가한 배지에서 로도토룰라균의배양을 통한 코엔자임큐텐의 제조방법
EP2186789B1 (de) *	2007-08-22	2013-12-25	Kaneka Corporation	Verfahren zur herstellung von reduziertem coenzym q10 und verfahren zu seiner stabilisierung
CN101307338B (zh) *	2008-07-17	2012-04-25	任雷	还原型辅酶q10的制备方法
CN101519681B (zh) *	2009-04-01	2012-11-07	宜都东阳光生化制药有限公司	一种辅酶q10的生产发酵工艺
EA201101519A1 (ru)	2009-05-11	2012-10-30	БЕРГ БАЙОСИСТЕМЗ, ЭлЭлСи	Способы диагностики метаболических нарушений, использующие эпиметаболические переключатели, многоаспектные внутриклеточные молекулы или факторы влияния
US20110269196A1 (en) *	2010-04-13	2011-11-03	Syracuse University	Coenzyme q10 production using sporidiobolus johnsonii
US9006493B2 (en)	2010-07-22	2015-04-14	Kaneka Corporation	Method for manufacturing a fat-soluble bioactive substance
WO2012129072A1 (en)	2011-03-18	2012-09-27	Particle Dynamics International, Llc	Solid particulate compositions comprising coenzyme q10
WO2012138765A1 (en)	2011-04-04	2012-10-11	Berg Pharma Llc	Methods of treating central nervous system tumors
CN102557912B (zh) *	2011-12-31	2015-01-07	内蒙古金达威药业有限公司	一种辅酶q10提取液的皂化方法
KR102285719B1 (ko) *	2012-03-02	2021-08-03	버그 엘엘씨	코엔자임 큐텐의 탐지 방법 및 키트
NZ713868A (en)	2013-04-08	2021-12-24	Berg Llc	Treatment of cancer using coenzyme q10 combination therapies
JP6595478B2 (ja)	2013-09-04	2019-10-23	バーグエルエルシー	コエンザイムｑ１０の連続注入によるがんの治療方法
CN103819326B (zh) *	2013-12-11	2016-08-17	湖南科源生物制品有限公司	一种从微生物中分离纯化辅酶q10的方法
JP2016208909A (ja) *	2015-05-08	2016-12-15	株式会社カネカ	脂溶性生理活性物質の製造方法
CN107709567B (zh) *	2015-06-23	2021-11-02	株式会社钟化	还原型辅酶q10的制造方法
CN105886562A (zh) *	2016-05-31	2016-08-24	兰州天和生物催化技术有限公司	微生物发酵法制备辅酶q10的方法
EP3480317A4 (de) *	2016-07-01	2020-01-22	Kaneka Corporation	Verfahren zur herstellung von koenzym q10
CN108048496B (zh) *	2017-12-25	2020-11-10	浙江新和成股份有限公司	氧化型辅酶q10的发酵生产方法、及由其制备而得的高含量氧化型辅酶q10
US10774350B2 (en)	2017-12-25	2020-09-15	Zhejiang Nhu Company Ltd.	Method for fermentative production of oxidized coenzyme Q10
US20210032666A1 (en) *	2018-03-28	2021-02-04	Kaneka Corporation	Method for producing coenzyme q10
JP7539831B2 (ja) *	2018-04-27	2024-08-26	株式会社カネカ	補酵素ｑ１０の製造方法
CN108997153B (zh) *	2018-07-25	2021-02-02	中国人民大学	从光合细菌中逐级提取多种高价值物质的方法
CN109055417B (zh)	2018-08-28	2020-07-07	浙江新和成股份有限公司	一种重组微生物、其制备方法及其在生产辅酶q10中的应用
CN109762757B (zh) *	2018-12-25	2020-01-07	神舟生物科技有限责任公司	一种高产辅酶q10类球红细菌及其诱变选育和应用
US11471426B2 (en)	2019-10-16	2022-10-18	American River Nutrition, Llc	Compositions comprising quinone and/or quinol and methods of preparations and use thereof
CN112755589B (zh) *	2021-02-23	2022-04-15	山东泰和水处理科技股份有限公司	精制辅酶q10的萃取方法及装置
CN115584357B (zh) *	2022-11-02	2023-10-20	广东润和生物科技有限公司	一种辅酶q10的发酵提取方法

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB930752A (en) *	1958-12-29	1963-07-10	Merck & Co Inc	Preparation of coenzyme q-10
US3066080A (en)	1961-03-22	1962-11-27	Merck & Co Inc	Fermentation production of coenzyme q-10
JPS488836Y1 (de)	1969-11-28	1973-03-08
JPS4825517B1 (de) *	1970-08-24	1973-07-30
JPS488836B1 (de) *	1970-03-31	1973-03-17
US3769170A (en) *	1970-03-31	1973-10-30	Ajinomoto Kk	Method of producing coenzyme q10 by microorganisms
JPS4825517A (de)	1971-08-04	1973-04-03
JPS5452790A (en) *	1977-10-04	1979-04-25	Kanegafuchi Chem Ind Co Ltd	Preparation of coenzyme q
JPS54110388A (en) *	1978-01-10	1979-08-29	Kanegafuchi Chem Ind Co Ltd	Microbial preparation of coenzyme q10
JPS5857155B2 (ja) *	1978-03-07	1983-12-19	協和醗酵工業株式会社	発酵法によるコエンチ−ムｑ↓１↓０の製造法
JPS54126792A (en) *	1978-03-20	1979-10-02	Hiroshi Aida	Production of coenzyme q10
JPS5527A (en) *	1978-05-25	1980-01-05	Kanegafuchi Chem Ind Co Ltd	Microbiological preparation of coenzyme q10
JPS5528A (en) *	1978-05-29	1980-01-05	Hiroshi Aida	Preparation of coenzyme q9
JPS5521756A (en) *	1978-08-04	1980-02-16	Hiroshi Aida	Preparation of coenzyme q
JPS593197B2 (ja)	1978-09-25	1984-01-23	十條製紙株式会社	補酵素ｑ↓１↓０の製造法
JPS5568295A (en) *	1978-11-17	1980-05-22	Godo Shiyusei Kk	Production of ubiquinone
JPS55148084A (en) *	1979-05-08	1980-11-18	Mitsubishi Gas Chem Co Inc	Incubation of microoranism
JPS5655196A (en) *	1979-10-08	1981-05-15	Mitsubishi Gas Chem Co Inc	Method of culturing microorganism
JPS56154994A (en) *	1980-04-30	1981-11-30	Sekisui Chem Co Ltd	Preparation of coenzyme q10
JPS56154996A (en) *	1980-05-02	1981-11-30	Sekisui Chem Co Ltd	Preparation of coenzyme q10
JPS5733599A (en) *	1980-08-06	1982-02-23	Mitsubishi Gas Chem Co Inc	Production of coenzyme q10
JPS5771396A (en) *	1980-10-07	1982-05-04	Univ Nagoya	Preparation of coenzyme q10
JPS5770834A (en) *	1980-10-17	1982-05-01	Takara Shuzo Co Ltd	Preparation of coenzyme q
AR228195A1 (es) *	1981-08-19	1983-01-31	Pfizer	Procedimiento microbiologico para la preparacion de hidroquinona
JPS6075294A (ja) *	1984-03-16	1985-04-27	Nisshin Flour Milling Co Ltd	補酵素ｑの製造法
DD236552A1 (de) *	1985-04-26	1986-06-11	Akad Wissenschaften Ddr	Verfahren zur herstellung von ubichinon-10
JPS61271994A (ja) *	1985-05-28	1986-12-02	Mitsubishi Gas Chem Co Inc	補酵素ｑ↓１↓０の製造法
JPS6336789A (ja) *	1986-07-29	1988-02-17	Mitsubishi Gas Chem Co Inc	補酵素ｑ↓１↓０の製造法
JPS63317092A (ja) *	1987-06-19	1988-12-26	Mitsubishi Gas Chem Co Inc	補酵素ｑ↓１↓０の製造法
JPS63102691A (ja)	1987-09-11	1988-05-07	Nisshin Flour Milling Co Ltd	補酵素ｑ↓１↓０の製造法
JPH088836B2 (ja)	1991-10-31	1996-01-31	社団法人長野県農村工業研究所	酵素により特性を改変した澱粉粒の利用方法
WO1996017626A2 (en) *	1994-12-06	1996-06-13	Ryan Pharmaceuticals, Inc.	Water soluble ubiquinone compositions, prodrugs, and methods relating thereto
JP3889481B2 (ja) *	1996-08-16	2007-03-07	株式会社カネカ	医薬組成物
JPH1057072A (ja) *	1996-08-22	1998-03-03	Alpha- Shokuhin Kk	ユビキノン−１０の生成方法
JP3926888B2 (ja) *	1997-05-27	2007-06-06	株式会社カネカ	コレステロール低下剤
JPH1156372A (ja)	1997-08-27	1999-03-02	Alpha- Shokuhin Kk	ユビキノン−１０の生成方法
JP3941998B2 (ja)	1999-08-24	2007-07-11	株式会社カネカ	コエンザイムｑ１０の製造法
CA2385132C (en)	1999-10-14	2010-12-14	Kyowa Hakko Kogyo Co., Ltd.	Process for producing ubiquinone-10
CA2429458A1 (en)	2000-11-20	2002-05-23	Kaneka Corporation	Process for producing coenzyme q10
JP2002191367A (ja)	2000-12-27	2002-07-09	Kanegafuchi Chem Ind Co Ltd	コエンザイムｑ１０の製造法
JP2002345469A (ja)	2001-04-25	2002-12-03	Kanegafuchi Chem Ind Co Ltd	コエンザイムｑ１０の製造法
JP3742602B2 (ja) *	2001-05-09	2006-02-08	株式会社カネカ	還元型補酵素ｑの安定な溶液
TWI310029B (de) *	2001-07-13	2009-05-21	Kaneka Corp
TWI237019B (en) *	2001-07-13	2005-08-01	Kaneka Corp	Method of producing reduced coenzyme Q10
CN1266102C (zh) *	2001-07-13	2006-07-26	钟渊化学工业株式会社	还原型辅酶q10在水溶液中结晶的方法
TWI237018B (en) *	2001-07-13	2005-08-01	Kaneka Corp	Method of producing reduced coenzyme Q10 crystals
TW200604159A (en) *	2001-07-13	2006-02-01	Kaneka Corp	Method of producing reduced coenzyme Q10 as oily product
TWI235146B (en) *	2001-07-16	2005-07-01	Kaneka Corp	Method of stabilizing reduced coenzyme q10 and method of acidic crystallization
JP3822479B2 (ja) *	2001-10-10	2006-09-20	株式会社カネカ	還元型補酵素ｑ水溶液の安定化組成
TWI329510B (en) *	2001-10-10	2010-09-01	Kaneka Corp	Method of stabilizing reduced coenzyme q10
TWI305547B (en) *	2001-12-27	2009-01-21	Kaneka Corp	Processes for producing coenzyme q10
JP3781118B2 (ja)	2003-03-03	2006-05-31	セイコーエプソン株式会社	配線基板の製造方法

2002
- 2002-12-26 TW TW091137404A patent/TWI305547B/zh not_active IP Right Cessation
- 2002-12-26 TW TW097132867A patent/TWI349039B/zh not_active IP Right Cessation
- 2002-12-27 AT AT02805906T patent/ATE388236T1/de not_active IP Right Cessation
- 2002-12-27 RU RU2004122912/13A patent/RU2298035C2/ru not_active IP Right Cessation
- 2002-12-27 US US10/500,249 patent/US20050069996A1/en not_active Abandoned
- 2002-12-27 AU AU2002357526A patent/AU2002357526B2/en not_active Expired
- 2002-12-27 EP EP02805906A patent/EP1466983B1/de not_active Expired - Lifetime
- 2002-12-27 DE DE60225478.7T patent/DE60225478C5/de not_active Expired - Lifetime
- 2002-12-27 CN CNB028262417A patent/CN100523205C/zh not_active Expired - Lifetime
- 2002-12-27 KR KR1020047010068A patent/KR100913464B1/ko not_active Expired - Fee Related
- 2002-12-27 WO PCT/JP2002/013766 patent/WO2003056024A1/ja active IP Right Grant
- 2002-12-27 CA CA2471763A patent/CA2471763C/en not_active Expired - Lifetime
- 2002-12-27 JP JP2003556541A patent/JP4256782B2/ja not_active Expired - Fee Related
2007
- 2007-10-31 US US11/981,181 patent/US7910340B2/en not_active Expired - Lifetime
2008
- 2008-05-07 JP JP2008121453A patent/JP5074287B2/ja not_active Expired - Fee Related
2011
- 2011-02-03 US US13/020,500 patent/US9315839B2/en not_active Expired - Fee Related
2012
- 2012-04-17 JP JP2012094126A patent/JP5788831B2/ja not_active Expired - Fee Related
2014
- 2014-06-18 JP JP2014125185A patent/JP2014166191A/ja active Pending
2016
- 2016-03-21 US US15/076,025 patent/US9926580B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2471763A1 (en)	2003-07-10
EP1466983B1 (de)	2008-03-05
CA2471763C (en)	2012-02-14
US20080171373A1 (en)	2008-07-17
EP1466983A1 (de)	2004-10-13
DE60225478C5 (de)	2015-09-17
US20110136191A1 (en)	2011-06-09
JP4256782B2 (ja)	2009-04-22
AU2002357526A1 (en)	2003-07-15
US7910340B2 (en)	2011-03-22
WO2003056024A1 (fr)	2003-07-10
JP2014166191A (ja)	2014-09-11
US9926580B2 (en)	2018-03-27
KR100913464B1 (ko)	2009-08-25
RU2004122912A (ru)	2005-06-27
US20160304915A1 (en)	2016-10-20
JP2008253271A (ja)	2008-10-23
EP1466983A4 (de)	2005-11-09
KR20040076266A (ko)	2004-08-31
AU2002357526B2 (en)	2007-10-18
US9315839B2 (en)	2016-04-19
TW200301306A (en)	2003-07-01
TW200900507A (en)	2009-01-01
TWI305547B (en)	2009-01-21
DE60225478T2 (de)	2009-02-26
TWI349039B (en)	2011-09-21
ATE388236T1 (de)	2008-03-15
JP5074287B2 (ja)	2012-11-14
RU2298035C2 (ru)	2007-04-27
US20050069996A1 (en)	2005-03-31
CN100523205C (zh)	2009-08-05
JP5788831B2 (ja)	2015-10-07
CN1608136A (zh)	2005-04-20
JP2012157360A (ja)	2012-08-23
JPWO2003056024A1 (ja)	2005-05-12

Publication	Publication Date	Title
DE60225478D1 (de)	2008-04-17	Verfahren zur herstellung des coenzyms q10
DE60127343D1 (de)	2007-05-03	Kontinuierliches Verfahren zur Herstellung von Wasserstoffperoxid in organischen Lösungsmitteln, wobei die Konzentration an Wasserstoff kleiner als 4,5>%Vol. und die Konzentration von Sauerstoff kleiner als 21,5 %Vol. beträgt.
DE60138029D1 (de)	2009-04-30	Verfahren zur herstellung von biopterinen
EP0936184A3 (de)	2000-06-28	Verfahren zur Herstellung von Chlor
HK1153508A1 (zh)	2012-03-30	尿酸氧化酶
DE60035418D1 (de)	2007-08-16	Wasserstoff-durchlässige metallmembran und verfahren zu ihrer herstellung
EP1186591A3 (de)	2002-03-20	Verfahren zur Herstellung von 3,3-Dimethylbutyraldehyd durch Oxidation von 3,3-Dimethylbutanol
ATE357413T1 (de)	2007-04-15	Katalysator und verfahren zur herstellung von wasserstoffperoxid
DE68918852D1 (de)	1994-11-17	Makrocylische aminophosphonsäurekomplexe, verfahren zur herstellung und formulierungen sowie verwendung.
AU1408900A (en)	2000-06-19	Method for synthesizing cdna
DE60321948D1 (de)	2008-08-14	Verfahren zur herstellung von 1,2-epoxy-3-chlorpropan
DE69329500D1 (de)	2000-11-02	Ein verfahren zur herstellung von immunosuppressiva und eine neuartige mikrobielle spezies, die dabei eingesetzt wird
ATE234827T1 (de)	2003-04-15	Verfahren zur herstellung von 3-aryl- benzofuranonen
DE60220281D1 (de)	2007-07-05	Verfahren zur herstellung von reduziertem coenzym q10
ATE480582T1 (de)	2010-09-15	Verfahren zur herstellung von expandierbaren styrolpolymerisaten
WO2002033057A3 (de)	2002-10-03	Cytochrom p450 monooxygenasen aus thermophilen bakterien
ATE387419T1 (de)	2008-03-15	Verfahren zur herstellung aliphatischer carbonsäuren aus aldehyden
DE68912871D1 (de)	1994-03-17	Verfahren zur Herstellung von Fluorkohlenwasserstoffen.
AU2001281859A1 (en)	2002-01-02	Immobilising carrier comprising a porous medium
DE69103445D1 (de)	1994-09-22	Verfahren zur Herstellung von organischen Carbonaten.
DE60010528D1 (de)	2004-06-09	Verfahren zur herstellung von fluorierten benzolen
ATE107611T1 (de)	1994-07-15	Herstellung von eisen-iii-chlorid.
ATE290096T1 (de)	2005-03-15	Coenzym zur herstellung von l-carnitin
ATE243182T1 (de)	2003-07-15	Verfahren zur herstellung von 2,3,5-trimethyl-p- benzochinon
HUP0001048A2 (hu)	2000-08-28	Új vegyületek

Legal Events

Date	Code	Title	Description
2009-04-02	8364	No opposition during term of opposition