JPS56154996A - Preparation of coenzyme q10 - Google Patents
Preparation of coenzyme q10Info
- Publication number
- JPS56154996A JPS56154996A JP5928680A JP5928680A JPS56154996A JP S56154996 A JPS56154996 A JP S56154996A JP 5928680 A JP5928680 A JP 5928680A JP 5928680 A JP5928680 A JP 5928680A JP S56154996 A JPS56154996 A JP S56154996A
- Authority
- JP
- Japan
- Prior art keywords
- electron transport
- agent
- coenzyme
- cultured
- inhibits
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 title abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 102000000634 Cytochrome c oxidase subunit IV Human genes 0.000 abstract 2
- 108050008072 Cytochrome c oxidase subunit IV Proteins 0.000 abstract 2
- 102000015782 Electron Transport Complex III Human genes 0.000 abstract 2
- 108010024882 Electron Transport Complex III Proteins 0.000 abstract 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 2
- 230000003647 oxidation Effects 0.000 abstract 2
- 238000007254 oxidation reaction Methods 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- JQLVBLQKCMHFHV-UHFFFAOYSA-N 1-heptyl-1-oxido-2H-quinolin-1-ium-2-ol Chemical compound C1=CC=C2[N+](CCCCCCC)([O-])C(O)C=CC2=C1 JQLVBLQKCMHFHV-UHFFFAOYSA-N 0.000 abstract 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 abstract 1
- 241000223252 Rhodotorula Species 0.000 abstract 1
- FHVXNPRYXLUHOQ-MZTIHRCLSA-N antimycin a1 Chemical compound O[C@@H]1O[C@@H](C)[C@H](OC(=O)C(C)C)[C@@H](CCCCCC)[C@H](O)O[C@H](C)[C@@H]1N[C@H](O)C1=CC=CC(NC=O)=C1O FHVXNPRYXLUHOQ-MZTIHRCLSA-N 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052979 sodium sulfide Inorganic materials 0.000 abstract 1
- GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PURPOSE: A yeast containing the titled substance is cultured in the presence of an agent that inhibits the electron transport to the electron transport complex III or IV in the course of oxidation in vivo to collect the titled substance in high yield.
CONSTITUTION: A yeast capable of producing coenzyme Q10, which belongs to Candida or Rhodotorula, is cultured in the presence of an agent that inhibits the electron transport to the electron transport complex III or IV in the course of in-vivo oxidation. The agent inhibiting the electron transport is, e.g., antimycin A1, n- heptylhydroxyquinoline-N-oxide, sodium azide or sodium sulfide. The cultivation is conduced in a general-purpose culture medium under usual conditions and the coenzyme Q10 produced is separated and purified by usual methods.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5928680A JPS56154996A (en) | 1980-05-02 | 1980-05-02 | Preparation of coenzyme q10 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5928680A JPS56154996A (en) | 1980-05-02 | 1980-05-02 | Preparation of coenzyme q10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56154996A true JPS56154996A (en) | 1981-11-30 |
| JPS6336754B2 JPS6336754B2 (en) | 1988-07-21 |
Family
ID=13108988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5928680A Granted JPS56154996A (en) | 1980-05-02 | 1980-05-02 | Preparation of coenzyme q10 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56154996A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003056024A1 (en) * | 2001-12-27 | 2003-07-10 | Kaneka Corporation | Processes for producing coenzyme q10 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4825517A (en) * | 1971-08-04 | 1973-04-03 |
-
1980
- 1980-05-02 JP JP5928680A patent/JPS56154996A/en active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4825517A (en) * | 1971-08-04 | 1973-04-03 |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003056024A1 (en) * | 2001-12-27 | 2003-07-10 | Kaneka Corporation | Processes for producing coenzyme q10 |
| US7910340B2 (en) | 2001-12-27 | 2011-03-22 | Kaneka Corporation | Processes for producing coenzyme Q10 |
| US9315839B2 (en) | 2001-12-27 | 2016-04-19 | Kaneka Corporation | Processes for producing coenzyme Q10 |
| US9926580B2 (en) | 2001-12-27 | 2018-03-27 | Kaneka Corporation | Process for producing coenzyme Q10 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6336754B2 (en) | 1988-07-21 |
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