JPS56154994A - Preparation of coenzyme q10 - Google Patents
Preparation of coenzyme q10Info
- Publication number
- JPS56154994A JPS56154994A JP5842080A JP5842080A JPS56154994A JP S56154994 A JPS56154994 A JP S56154994A JP 5842080 A JP5842080 A JP 5842080A JP 5842080 A JP5842080 A JP 5842080A JP S56154994 A JPS56154994 A JP S56154994A
- Authority
- JP
- Japan
- Prior art keywords
- coenzyme
- linalool
- separated
- producing
- medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 title abstract 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 abstract 4
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract 3
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 abstract 2
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 241000222120 Candida <Saccharomycetales> Species 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 2
- 239000005515 coenzyme Substances 0.000 abstract 2
- 229930007744 linalool Natural products 0.000 abstract 2
- 239000002609 medium Substances 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 241001337994 Cryptococcus <scale insect> Species 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 241000223252 Rhodotorula Species 0.000 abstract 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 abstract 1
- 235000011130 ammonium sulphate Nutrition 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PURPOSE: A yeast containing the titled substance is cultured in the presence of linalool to facilitate the isolation and purification of the titled substance, thus producing the objective coenzyme in high yield.
CONSTITUTION: A yeast capable of producing coenzyme Q10, which belongs to Candida, Torulopsis, Rhodotorula or Cryptococcus, is aerobically culutured in a general-purpose medium containing carbon sources as glucose and nitrogen sources as ammonium sulfate. Linalool is dissolved in 1ml of ethanol by an amount necessary for 1l of the culture medium and added to the medium, resultingly about 1.5W 50mg/g of the produced dry cells is appropriate. After the cultivation, the cells are separated, extracted with hexane, then the coenzyme is separated and purified by chromatography.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5842080A JPS56154994A (en) | 1980-04-30 | 1980-04-30 | Preparation of coenzyme q10 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5842080A JPS56154994A (en) | 1980-04-30 | 1980-04-30 | Preparation of coenzyme q10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56154994A true JPS56154994A (en) | 1981-11-30 |
| JPS6244916B2 JPS6244916B2 (en) | 1987-09-24 |
Family
ID=13083882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5842080A Granted JPS56154994A (en) | 1980-04-30 | 1980-04-30 | Preparation of coenzyme q10 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56154994A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003056024A1 (en) * | 2001-12-27 | 2003-07-10 | Kaneka Corporation | Processes for producing coenzyme q10 |
-
1980
- 1980-04-30 JP JP5842080A patent/JPS56154994A/en active Granted
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003056024A1 (en) * | 2001-12-27 | 2003-07-10 | Kaneka Corporation | Processes for producing coenzyme q10 |
| US7910340B2 (en) | 2001-12-27 | 2011-03-22 | Kaneka Corporation | Processes for producing coenzyme Q10 |
| US9315839B2 (en) | 2001-12-27 | 2016-04-19 | Kaneka Corporation | Processes for producing coenzyme Q10 |
| US9926580B2 (en) | 2001-12-27 | 2018-03-27 | Kaneka Corporation | Process for producing coenzyme Q10 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6244916B2 (en) | 1987-09-24 |
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