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JPS5770834A - Preparation of coenzyme q - Google Patents

Preparation of coenzyme q

Info

Publication number
JPS5770834A
JPS5770834A JP14611480A JP14611480A JPS5770834A JP S5770834 A JPS5770834 A JP S5770834A JP 14611480 A JP14611480 A JP 14611480A JP 14611480 A JP14611480 A JP 14611480A JP S5770834 A JPS5770834 A JP S5770834A
Authority
JP
Japan
Prior art keywords
coenzyme
reduced coenzyme
pref
manganese dioxide
catalytic oxidation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14611480A
Other languages
Japanese (ja)
Inventor
Fusao Kimizuka
Hisao Matsunaga
Akira Obayashi
Osamu Tanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takara Shuzo Co Ltd
Taiho Pharmaceutical Co Ltd
Original Assignee
Takara Shuzo Co Ltd
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takara Shuzo Co Ltd, Taiho Pharmaceutical Co Ltd filed Critical Takara Shuzo Co Ltd
Priority to JP14611480A priority Critical patent/JPS5770834A/en
Publication of JPS5770834A publication Critical patent/JPS5770834A/en
Pending legal-status Critical Current

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To prepare coenzyme Q useful as a remedy for cardiac insufficiency, rapidly, without side reactions, with simple operation, by the catalytic oxidation of reduced coenzyme Q in a hydrophobic solvent using manganese dioxide.
CONSTITUTION: Coenzyme Q is pepared by the catalytic oxidation of reduced coenzyme Q of formula (n is integer 1W12) (2,3-dimethyoxy-5-methyl-6-prenyl hydroquinone) in a hydrophobic solvent (e.g. nexane, petroleum ether, etc.) with manganese dioxide. The concentration of the reduced coenzyme Q is usually 1W20w/v%, pref. 10w/v%, and the reaction temperature is pref. 10W40°C.
COPYRIGHT: (C)1982,JPO&Japio
JP14611480A 1980-10-17 1980-10-17 Preparation of coenzyme q Pending JPS5770834A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14611480A JPS5770834A (en) 1980-10-17 1980-10-17 Preparation of coenzyme q

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14611480A JPS5770834A (en) 1980-10-17 1980-10-17 Preparation of coenzyme q

Publications (1)

Publication Number Publication Date
JPS5770834A true JPS5770834A (en) 1982-05-01

Family

ID=15400465

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14611480A Pending JPS5770834A (en) 1980-10-17 1980-10-17 Preparation of coenzyme q

Country Status (1)

Country Link
JP (1) JPS5770834A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003006412A1 (en) * 2001-07-13 2003-01-23 Kaneka Corporation Method of producing reduced coenzyme q10
WO2003006410A1 (en) * 2001-07-13 2003-01-23 Kaneka Corporation Method of producing reduced coenzyme q10 as oily product
WO2003006408A1 (en) * 2001-07-13 2003-01-23 Kaneka Corporation Method of producing reduced coenzyme q10 using solvent with high oxidation-protective effect
WO2003006409A1 (en) * 2001-07-13 2003-01-23 Kaneka Corporation Method of producing reduced coenzyme q10 crystals with excellent handling properties
EP1466983A4 (en) * 2001-12-27 2005-11-09 Kaneka Corp Processes for producing coenzyme q10
WO2018116512A1 (en) 2016-12-22 2018-06-28 横浜ゴム株式会社 Pneumatic tire

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7524993B2 (en) 2001-07-13 2009-04-28 Kaneka Corporation Method of producing reduced coenzyme Q10 as oily product
EP2402303A2 (en) 2001-07-13 2012-01-04 Kaneka Corporation A reduced coenzyme Q10 crystal
WO2003006408A1 (en) * 2001-07-13 2003-01-23 Kaneka Corporation Method of producing reduced coenzyme q10 using solvent with high oxidation-protective effect
WO2003006409A1 (en) * 2001-07-13 2003-01-23 Kaneka Corporation Method of producing reduced coenzyme q10 crystals with excellent handling properties
WO2003006412A1 (en) * 2001-07-13 2003-01-23 Kaneka Corporation Method of producing reduced coenzyme q10
EP3321248A3 (en) * 2001-07-13 2018-06-06 Kaneka Corporation Method of producing reduced coenzyme q10 using solvent with high oxidation-protective effect
US7105709B2 (en) 2001-07-13 2006-09-12 Kaneka Corporation Method of producing reduced coenzyme q10
US7145044B2 (en) 2001-07-13 2006-12-05 Kaneka Corporation Method of producing reduced coenzyme Q10 using solvent with high oxidation-protective effect
US7208639B2 (en) 2001-07-13 2007-04-24 Kaneka Corporation Method of producing reduced coenzyme Q10 as oily product
AU2002318844B2 (en) * 2001-07-13 2008-06-05 Kaneka Corporation Method of producing reduced coenzyme Q10 crystals with excellent handling properties
AU2002318845B2 (en) * 2001-07-13 2008-09-11 Kaneka Corporation Method of producing reduced coenzyme Q10 as oily product
EP3321248A2 (en) 2001-07-13 2018-05-16 Kaneka Corporation Method of producing reduced coenzyme q10 using solvent with high oxidation-protective effect
WO2003006410A1 (en) * 2001-07-13 2003-01-23 Kaneka Corporation Method of producing reduced coenzyme q10 as oily product
JP2009046495A (en) * 2001-07-13 2009-03-05 Kaneka Corp Method for producing reduced coenzyme q10 crystal with excellent handling property
EP1415969A4 (en) * 2001-07-13 2005-04-27 Kaneka Corp Method of producing reduced coenzyme q10 using solvent with high oxidation-protective effect
EP2228360A1 (en) * 2001-07-13 2010-09-15 Kaneka Corporation Method of producing reduced coenzyme Q10 using solvent with high oxidation-protective effect
EP2289866A2 (en) 2001-07-13 2011-03-02 Kaneka Corporation Method of producing reduced coenzyme Q10 as oily product
US8853464B2 (en) 2001-07-13 2014-10-07 Kaneka Corporation Method of producing reduced coenzyme Q10 crystals with excellent handling properties
US8003828B2 (en) 2001-07-13 2011-08-23 Kaneka Corporation Method of producing reduced coenzyme Q10 crystals with excellent handling properties
AU2002318843B2 (en) * 2001-07-13 2008-10-30 Kaneka Corporation Method of producing reduced coenzyme Q10 using solvent with high oxidation-protective effect
EP2402303A3 (en) * 2001-07-13 2012-04-25 Kaneka Corporation A reduced coenzyme Q10 crystal
JP2012157360A (en) * 2001-12-27 2012-08-23 Kaneka Corp Processes for producing coenzyme q10
US7910340B2 (en) 2001-12-27 2011-03-22 Kaneka Corporation Processes for producing coenzyme Q10
US9315839B2 (en) 2001-12-27 2016-04-19 Kaneka Corporation Processes for producing coenzyme Q10
US9926580B2 (en) 2001-12-27 2018-03-27 Kaneka Corporation Process for producing coenzyme Q10
JP2008253271A (en) * 2001-12-27 2008-10-23 Kaneka Corp Method for producing coenzyme q10
EP1466983A4 (en) * 2001-12-27 2005-11-09 Kaneka Corp Processes for producing coenzyme q10
WO2018116512A1 (en) 2016-12-22 2018-06-28 横浜ゴム株式会社 Pneumatic tire

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