JPS5452790A - Preparation of coenzyme q - Google Patents
Preparation of coenzyme qInfo
- Publication number
- JPS5452790A JPS5452790A JP11966977A JP11966977A JPS5452790A JP S5452790 A JPS5452790 A JP S5452790A JP 11966977 A JP11966977 A JP 11966977A JP 11966977 A JP11966977 A JP 11966977A JP S5452790 A JPS5452790 A JP S5452790A
- Authority
- JP
- Japan
- Prior art keywords
- coenzyme
- alkali
- acid
- cells
- suspension
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000005515 coenzyme Substances 0.000 title 1
- 239000003513 alkali Substances 0.000 abstract 3
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 abstract 3
- 235000017471 coenzyme Q10 Nutrition 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 239000007900 aqueous suspension Substances 0.000 abstract 2
- 230000000813 microbial effect Effects 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 239000000725 suspension Substances 0.000 abstract 2
- 241000222178 Candida tropicalis Species 0.000 abstract 1
- 238000010306 acid treatment Methods 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- UUGXJSBPSRROMU-WJNLUYJISA-N ubiquinone-9 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O UUGXJSBPSRROMU-WJNLUYJISA-N 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To prepare coenzyme Q useful for the remedy of congestive heart, etc., in high yield, by treating an aqueous suspension of microbial cells with acid or alkali, or mechanically crushing said suspension drying the treated or caushed suspension to obtain dried cells, and extracting and purifying the dried cells with an organic solvent.
CONSTITUTION: Aqueous suspension of coenzyme Q-containing microbial cells, e.g. coenzyme Q9-producing Candida tropicalis LAM 4924, is treated with an acid or an alkali, or crushed by mechanical forces such as grinding, impact, shear, etc., and dried by a drum-type drier, etc. The acid treatment is carried out at pH≤1, and 40W120°C for ≥3 min; and the alkali treatment is e.g. pH8W12, 50W120°C for 1W15 min. The dried cells are extracted with a hydrophilic solvent such as ethanol, the extract is transferred to a hydrophobic solvent, decomposed lipid is removed by washing, and the purified fraction of coenzyme Q is obtained by the chromatographic treatment of the solution
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11966977A JPS5452790A (en) | 1977-10-04 | 1977-10-04 | Preparation of coenzyme q |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11966977A JPS5452790A (en) | 1977-10-04 | 1977-10-04 | Preparation of coenzyme q |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5452790A true JPS5452790A (en) | 1979-04-25 |
| JPS6117471B2 JPS6117471B2 (en) | 1986-05-07 |
Family
ID=14767116
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11966977A Granted JPS5452790A (en) | 1977-10-04 | 1977-10-04 | Preparation of coenzyme q |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5452790A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008253271A (en) * | 2001-12-27 | 2008-10-23 | Kaneka Corp | Method for producing coenzyme q10 |
| WO2019189290A1 (en) * | 2018-03-28 | 2019-10-03 | 株式会社カネカ | Coenzyme q10 production method |
-
1977
- 1977-10-04 JP JP11966977A patent/JPS5452790A/en active Granted
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008253271A (en) * | 2001-12-27 | 2008-10-23 | Kaneka Corp | Method for producing coenzyme q10 |
| US9315839B2 (en) | 2001-12-27 | 2016-04-19 | Kaneka Corporation | Processes for producing coenzyme Q10 |
| US9926580B2 (en) | 2001-12-27 | 2018-03-27 | Kaneka Corporation | Process for producing coenzyme Q10 |
| WO2019189290A1 (en) * | 2018-03-28 | 2019-10-03 | 株式会社カネカ | Coenzyme q10 production method |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6117471B2 (en) | 1986-05-07 |
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