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BR112018067458A2 - anticorpos para tigit - Google Patents

anticorpos para tigit

Info

Publication number
BR112018067458A2
BR112018067458A2 BR112018067458A BR112018067458A BR112018067458A2 BR 112018067458 A2 BR112018067458 A2 BR 112018067458A2 BR 112018067458 A BR112018067458 A BR 112018067458A BR 112018067458 A BR112018067458 A BR 112018067458A BR 112018067458 A2 BR112018067458 A2 BR 112018067458A2
Authority
BR
Brazil
Prior art keywords
tigit
monoclonal antibodies
antibodies
inhibit
binding
Prior art date
Application number
BR112018067458A
Other languages
English (en)
Inventor
Yun Tso J
Tsurushita Naoya
Duramad Omar
Original Assignee
Abmuno Therapeutics Llc
Jn Biosciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abmuno Therapeutics Llc, Jn Biosciences Llc filed Critical Abmuno Therapeutics Llc
Publication of BR112018067458A2 publication Critical patent/BR112018067458A2/pt

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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    • A61K39/08—Clostridium, e.g. Clostridium tetani
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    • A61K39/02—Bacterial antigens
    • A61K39/085—Staphylococcus
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    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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Abstract

a invenção refere-se a anticorpos monoclonais que se ligam especificamente a tigit. os anticorpos monoclonais têm a capacidade de realizar uma importante ativação de células t e células naturais assassinas, inibindo a ligação do tigit a cd155. os anticorpos monoclonais podem ser usados para o tratamento de câncer e doenças infecciosas, entre outras aplicações.
BR112018067458A 2016-03-04 2017-03-03 anticorpos para tigit BR112018067458A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662304045P 2016-03-04 2016-03-04
US201662413025P 2016-10-26 2016-10-26
PCT/US2017/020719 WO2017152088A1 (en) 2016-03-04 2017-03-03 Antibodies to tigit

Publications (1)

Publication Number Publication Date
BR112018067458A2 true BR112018067458A2 (pt) 2019-01-02

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BR112018067458A BR112018067458A2 (pt) 2016-03-04 2017-03-03 anticorpos para tigit

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US (3) US10537633B2 (pt)
EP (1) EP3423089A4 (pt)
JP (3) JP7109382B2 (pt)
KR (2) KR102355950B1 (pt)
CN (2) CN108883164B (pt)
AU (2) AU2017228474C1 (pt)
BR (1) BR112018067458A2 (pt)
CA (1) CA3014934A1 (pt)
IL (1) IL261188B (pt)
MX (1) MX2018010485A (pt)
MY (2) MY202516A (pt)
PH (1) PH12018501778A1 (pt)
SA (2) SA522431756B1 (pt)
SG (1) SG11201806992VA (pt)
TW (3) TWI752012B (pt)
UA (1) UA125898C2 (pt)
UY (1) UY37141A (pt)
WO (1) WO2017152088A1 (pt)

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CA2860170C (en) 2010-12-22 2022-06-14 The Board Of Trustees Of The Leland Stanford Junior University Superagonists and antagonists of interleukin-2
CN105722860A (zh) 2013-09-24 2016-06-29 梅迪塞纳医疗股份有限公司 白介素-2融合蛋白及其应用
EP3134102B1 (en) 2014-04-24 2019-07-03 The Board of Trustees of The Leland Stanford Junior University Superagonists, partial agonists and antagonists of interleukin-2
TWI715587B (zh) 2015-05-28 2021-01-11 美商安可美德藥物股份有限公司 Ｔｉｇｉｔ結合劑和彼之用途
BR112018067458A2 (pt) 2016-03-04 2019-01-02 Abmuno Therapeutics Llc anticorpos para tigit
TWI773694B (zh) 2016-10-11 2022-08-11 美商艾吉納斯公司 抗ｌａｇ－３抗體及其使用方法
CN110662552A (zh) 2016-11-30 2020-01-07 昂科梅德制药有限公司 包含tigit结合剂的癌症治疗方法
WO2018187191A1 (en) 2017-04-03 2018-10-11 Jounce Therapeutics, Inc Compositions and methods for the treatment of cancer
WO2018204363A1 (en) 2017-05-01 2018-11-08 Agenus Inc. Anti-tigit antibodies and methods of use thereof
CN110799213A (zh) 2017-06-01 2020-02-14 康姆普根有限公司 三联组合抗体疗法
WO2018229163A1 (en) * 2017-06-14 2018-12-20 King's College London Methods of activating v delta 2 negative gamma delta t cells
CN111201035A (zh) 2017-06-19 2020-05-26 梅迪塞纳医疗股份有限公司 Il-2超激动剂、激动剂及其融合体的用途和方法
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