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TWI517050B - 供應鏈管理之系統 - Google Patents

供應鏈管理之系統 Download PDF

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TWI517050B
TWI517050B TW099137775A TW99137775A TWI517050B TW I517050 B TWI517050 B TW I517050B TW 099137775 A TW099137775 A TW 099137775A TW 99137775 A TW99137775 A TW 99137775A TW I517050 B TWI517050 B TW I517050B
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ingestible device
detector
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馬克 茲德布里克
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    • G06K17/00—Methods or arrangements for effecting co-operative working between equipments covered by two or more of main groups G06K1/00 - G06K15/00, e.g. automatic card files incorporating conveying and reading operations
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04B—TRANSMISSION
    • H04B5/00—Near-field transmission systems, e.g. inductive or capacitive transmission systems
    • H04B5/20—Near-field transmission systems, e.g. inductive or capacitive transmission systems characterised by the transmission technique; characterised by the transmission medium
    • H04B5/22—Capacitive coupling
    • A—HUMAN NECESSITIES
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    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
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    • A61B5/061—Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body
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    • H—ELECTRICITY
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    • H04B—TRANSMISSION
    • H04B5/00—Near-field transmission systems, e.g. inductive or capacitive transmission systems
    • H04B5/40—Near-field transmission systems, e.g. inductive or capacitive transmission systems characterised by components specially adapted for near-field transmission
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    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04B—TRANSMISSION
    • H04B5/00—Near-field transmission systems, e.g. inductive or capacitive transmission systems
    • H04B5/70—Near-field transmission systems, e.g. inductive or capacitive transmission systems specially adapted for specific purposes
    • H04B5/77—Near-field transmission systems, e.g. inductive or capacitive transmission systems specially adapted for specific purposes for interrogation

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Description

供應鏈管理之系統
相關申請案之交互參考
此申請案主張來自由發明人Mark Zdeblick於2009年11月4日所申請之稱為可吞食事件發生器(Ingestible Event Makers)的供應鏈管理之方法、裝置及系統的美國臨時申請案序號61/252,182之依據35 USC 119的優先權，其在此被倂入。
本發明係有關於使用電子裝置來追蹤產品之方法及系統。更特別而言，本揭示包括追蹤自來源至消費者的醫藥庫存之方法、裝置、及系統。
醫藥產品的供應商關心自產品離開製造者的時候至產品被發送至最終使用者的時候之替代原始產品的假冒產品。此外，有精確地判定包裝的數量及內容，使得經銷商可識別整個供應鏈的產品之需求。已知的方法及系統使用近場通訊，諸如RFID。這些已知的方法具有諸如缺乏資料完整性，機密性等的固有限制。因此，需要的是用以查詢產品，以確保自製造者至最終使用者或消費者之整個供應鏈的產品之有效及產地的系統。
揭示的是一種用以管理供應鏈環境中的產品供應之系統。在不同的觀點中，本發明包括探測各種產品的電容板，而導致產品有效或無效的指示。以此方式，可達成不同的供應鏈或其他的追求。
這些產品包括，例如，靜脈輸液套管(IV bags)、注射器、可吞食事件發生器(IEMs)及類似的裝置，如於如WO/2006/116718所公開之PCT申請案序號PCT/US2006/016370；如WO/2008/052136所公開之PCT申請案序號PCT/US2007/082563；如WO/2008/063626所公開之PCT申請案序號PCT/US2007/024225；如WO/2008/066617所公開之PCT申請案序號PCT/US2007/022257；如WO/2008/095183所公開之PCT申請案序號PCT/US2008/052845；如WO/2008/101107所公開之PCT申請案序號PCT/US2008/053999；如WO/2008/112577所公開之PCT申請案序號PCT/US2008/056296；如WO/2008/112578所公開之PCT申請案序號PCT/US2008/056299；如WO/2009/042812所公開之PCT申請案序號PCT/US2008/077753；及如WO/2008/008281所公開之PCT申請案序號PCT/US2007/015547；以及美國臨時申請案序號61/142,849；61/142,861；61/177,611；61/173,564中所揭示及敘述；其全部在此被倂入作為參考。某些產品典型上可被設計以包括導電材料/組件。藉由電容板來探測產品的導電材料及組件之電容耦合的使用可表示產品的導電組件之正確組態的顯現。另一種是，探測的時候無法通訊地耦合可表示產品不符合，例如，缺少一個或多個導電材料，不正確的組構等。
現在參照圖1A，在醫藥產品12a(諸如藥丸或藥片)內部的裝置10a被完整地封裝，且經由探測器來予以測試，如底下詳細的討論。根據本發明的不同觀點，裝置10a可被設置於產品12a內，或固定於產品12a的表面，如本發明的範圍內所考慮到的。裝置10a包括用於通訊的控制模組，及用以儲存資訊(諸如身份)的記憶體。裝置10a的探測被實施，以確保例如裝置10a仍然是作用的。此探測使用電容耦合法，其中，有第一探測電容板20a至裝置10a的一側上之第一金屬或材料14a，及第二探測電容板30a至裝置10a的另一側上之第二金屬或材料16a的電容耦合。可達成使用電容耦合來探測的不同方式，例如，金屬、金屬墊等。根據本發明的一個觀點，例如，有材料14a和電容板20a，與材料16a和電容板30a之間的電容耦合。板20a及30a為可經由電容耦合而與裝置10a相通訊之探測器。板20a及30a係電氣連接至可接收來自板20a及30a的資訊，以及處理此資訊的系統(未顯示)。再者，根據本發明的不同觀點，此產品可以非導電材料來予以塗佈。
根據本發明的不同觀點，有被包括為裝置10的部分之不同的組件。例如，裝置10可為可吞食事件發生器(IEM)，其具有可使用電容耦合預先吞食來予以讀取，及使用傳輸導體後消費(transconduction post-consumption)來予以通訊之獨特身份。IEM的不同觀點係揭示於2009年9月21日所申請之稱為具有部分電源的通訊系統之美國專利申請案12/564,017中，其的全部揭示在此被倂入作為參考。
現在參照圖1B，根據本發明的一個觀點，裝置10b係顯示為產品12b的部分。裝置10b包括設置在裝置10b的表面上之第一材料14b及第二材料16b，用以形成電容連接。材料14b及16b係與裝置10b的控制模組相通訊。探測器20b及30b係分別電容地耦合至材料14b及16b。因此，當探測器20b及30b係以交流(AC)電壓來開啟電源時，然後材料14b及16b係電容地耦合至探測器20b及30b。因此，儲存於裝置10b的記憶體中之與裝置10b相關聯的資訊可藉由裝置10b的控制模組來予以編碼，且與使用電容耦合的探測器通訊。
現在參照圖1C，根據本發明，裝置10c係顯示而固定於產品12c。裝置10c包括設置在裝置10c的護裙(skirt)18c之外緣周圍的第一材料14c及第二材料16c，其中，材料14c及16c的至少部分係設置於護裙18c上。再者，材料14c及16c係耦接至裝置10c的控制模組，用以經由來自裝置10c的控制模組之電容耦合而允許用於通訊，以讓裝置10c的身份能經由探測器20c及30c而傳送至系統。根據本發明的一個觀點，材料14c及16c為導電油墨，諸如可吞食石墨，或以碳為基礎的油墨或膏。探測器20c及30c係藉由AC源來予以供電，且當靠近材料14c及16c時，探測器20c及30c可使用分別經由材料14c及16c的電容耦合而與裝置10c相通訊。再者，根據本發明的另一個觀點，探測器22c及32c係設置在不同位置處的材料14c及16c之近側，以允許用於裝置10c的選擇定位。一旦探測器20c及30c係以AC電壓來予以供電，且裝置10c係設置成接近探測器20c及30c，則材料14c及16c可被使用來傳遞裝置10c，與經由電容耦合而連接至探測器20c及30c的系統之間的資訊。
現在參照圖1D，裝置10d係根據本發明的另一個觀點來予以顯示。複合材料14d係設置在與裝置10d相關聯之材料19a的表面。裝置10的材料19a及材料19b為不相似的材料，且構成裝置10d的部分電源。例如，材料19a可為CuCl，而材料19b可為Mg。此裝置也包括連接點19c，其係實體及電氣地連接至複合材料14d。裝置10d包括複合材料16d，其與裝置10d實體上相關聯。因此，材料19b係經由裝置10d而耦接至複合材料16d。因此，當探測器或板(與圖1A-1C中所顯示的那些類似，且以AC電壓來予以供電)接近裝置10d時，在複合材料14d與一個探測器之間，以及在複合材料16d與另一個探測器之間，有電容耦合。使用電容耦合，資訊可在裝置10d與連接至接近裝置10d的探測器之系統之間被通訊。
現在參照圖2，電壓源(例如，AC電壓，或其他的隔離或交流源)40以高頻(例如，1 MHz等)運行。此電壓源係連接至探測器或板。裝置10包括控制模組50，及與材料(例如，圖1A的材料14及16)耦接的接合墊52。根據本發明的一個觀點，在裝置10的內部是二極體54(諸如產生內部供應電壓的蕭特基二極體或其他型式的二極體)，以及具有某些阻抗的開關56(其被導通及關閉而改變裝置10的阻抗)。阻抗的變化係使用來傳送關於裝置10的身份之資訊。阻抗的改變讓與裝置10相關聯的資訊能經由使用電容耦合的探測器(如藉由電容器58及60所代表)而被編碼，及傳送至系統。此資訊係藉由連接至藉由電容器所代表的探測器之系統來予以擷取，且經由跨接標記為R-樣本的阻抗之取樣放大器而被讀取為Vout。
一旦控制模組50經由這些板而接近或曝露於此電壓源，則有經由電容耦合的能量轉移，且裝置10可產生可被偵測的振盪訊號。此振盪訊號包含資訊及隔離訊號，其如可根據電容耦合的程度而可被編碼成例如1 MHz訊號或類似的頻率(例如，500 kHz)。來源40的電壓將藉由圖1的電容板或探測器20和30，與其材料14和16之間達到的多少電容耦合來予以判定。因此，在代表也許5伏特的高頻時，探測器(諸如探測器20或30)與材料之間的電容值係藉由電容器58及60所表示。
現在參照圖2A及2B，根據本發明的另一個觀點，二極體橋接器係顯示，此二極體橋接器為板20和30，與裝置10的材料14和16之間的互動之電路表示。於板20和30(標記為「板1」及「板2」)處出現的隔離電壓導致以裝置10的高電壓及低電壓之形式的能量轉移。裝置10包括作為處理器或邏輯單元的部分之控制模組。此邏輯單元可為處理器、微處理器、多模組裝置或任何形式的積體電路。此邏輯單元係與導電材料14和16，及板20和30(標記為「板1」及「板2」)相通訊。當板20和30係以AC源來予以供電時，此邏輯單元儲存能量，且稍後釋放此能量，以傳送資訊。
根據本發明的一個觀點，若在電容板/探測器，和與裝置10實體上相關聯的材料之間有一個微法拉電容器，則處於代表需用於電容耦合的較低電壓之高隔離頻率。根據本發明的另一個觀點，若有一個微微法拉電容器，則如將藉由熟習此項技術者所瞭解的，會需要較大的電壓。實際上通過的電流量將根據電容板/探測器20和30之間所導致的電路之間的阻抗，如例如於圖1中所顯示。因此，使圖1A-1C的電容板20和電容板30短路將導致通過顯著的電流，其可例如藉由如圖2中所顯示的取樣放大器來予以偵測。此輸出為通過取樣放大器，其基本上著眼於通過此迴路的電流，及藉由控制模組50所導致的此電流之調變。
根據本發明的不同觀點，電容耦合可使用為直流(DC)源裝置的裝置(其為互通性而被修改)，例如，具有在適當位置的整流器之裝置，以提供晶片(其的阻抗可被調變)上的穩定電壓。
現在參照圖3A及3B，根據本發明的不同個觀點，電容板/探測器，與用以接收資訊之連接至此的系統可被整合，或者是與不同的結構組件及其他裝置(例如，具有電容板20和30之如圖3A中所顯示的管狀結構60)相關聯。為了例示，具有IEM或類似裝置10的一個或多個醫藥品可被引入至此結構中。裝置10可手動地，或經由自動化裝置而自動地被引入。當此裝置行經結構60時，裝置10係藉由管60中的電容板20和30來予以探測。在不同的觀點中，其他的裝置及/或組件可相關聯。在一例中，可程式裝置可與電容耦合裝置通訊地相關聯，以接收及/或發送藉由電容耦合裝置所傳送的資料及/或資訊。為了延續先前的圖示，一旦一些產品(其可為藥丸)的全部或部分係藉由與探測器/板20和30相關聯的電容耦合系統來予以探測或「讀取」，則電容耦合系統可與資料庫相通訊(例如，無線、有線等)，此資料庫具有顯示裝置，以供進一步的儲存、顯示、運用等。以此方式，個別資料、資料、大量的資料等可為了不同的目的來予以處理。一個此種目的可例如為例如在諸如壓片(tablet pressing)或其他程序的製造程序期間、在藥房驗證程序期間、在藥房處方程序期間等，用以追蹤供應鏈應用中的醫藥品。不同的程序可為互補的、合倂的等。一個此種範例為經由讀取號碼的有效性。若其為有效的(例如，可讀取的)，則此藥片被接受。若否，則此藥片被捨棄。因此，使用具有振盪電源之簡單的手持式讀取器，使用者或醫療保健提供者可使用與其相關聯的裝置10來探測此產品(其可為根據本發明的一個觀點之藥丸或藥片)，且判定是否此藥丸為真實或假冒的產品。
現在參照圖4A及4B，根據本發明的另一個觀點，具有裝置10的藥丸係顯示具有為非導電或相當防滲的塗料之塗料74，且此藥丸本身包含非導電藥粉。如所顯示的區域72(例如，錐形區域)包含導電材料70，例如，與其他醫藥產品、輔藥、安慰劑材料等混合之小微粒或顆粒的導電材料，使得區域72被轉換成導電區域。例如，可使用石墨或其他的導電材料(例如，十個中的一個部分、十個中的五個部分等)，使得區域72為導電的。其他的材料及成份是可行的，例如，具有導電微粒於其中的膠囊或液體膠囊等。因此，在足夠高的頻率時，區域72中之導電材料70的微粒可一起被短路。熟習此項技術者將瞭解導電材料70可包括不同的材料及外形，以及其組合，例如，不同尺寸的微粒、接線、金屬膜、線狀物等。本發明的範圍不會因區域72中所使用之導電材料70的型式或形狀而受限。
根據本發明的另一個觀點，導電材料70可經由各種方法及比例來予以整合或構成。在一例中，裝置10係嵌入「環形」粉末，或者是與「環形」粉末機械地相關聯，且形成於「環形」粉末中的孔係以導電微粒等填滿，或者是與導電微粒等相關聯。導電區域的尺寸、面積、體積、位置或其他參數可改變成在此所述的功能可被實施的程度。
根據本發明的另一個觀點且如圖5中所顯示，電容板或探測器80和82係耦接至用以收集資料的系統。探測器80和82係使用來經由分別與材料84和86的電容耦合而探測裝置10。阻抗回授系統可被使用將其驅動成彼此相當接近，且一旦電流到達某個數量，會使用此來測量距離。使用足夠高的阻抗，此系統可使用於各種應用中，例如，用以確認裝置10存在的製造環境正準確地操作等。
根據本發明的另一個觀點，電容耦合探測器/板與裝置10之間的緊鄰可使隱私方面促進、提升等。在某些方面，某些相關的裝置可包括，例如，具有與CMOS電晶體(其被計時成導通與關閉、開啟等)並聯的蕭特基二極體之電路。其他的電路設計及修改是可行的。
10．．．裝置
10a．．．裝置
10b．．．裝置
10c．．．裝置
10d．．．裝置
12a．．．醫藥產品
12b．．．產品
12c．．．產品
14．．．材料
14a．．．第一金屬或材料
14b．．．第一材料
14c．．．第一材料
14d．．．複合材料
16．．．材料
16a．．．第二金屬或材料
16b．．．第二材料
16c．．．第二材料
16d．．．複合材料
18c．．．護裙
19a．．．材料
19b．．．材料
19c．．．連接點
20a．．．第一探測電容板
20b．．．探測器
20c．．．探測器
22c．．．探測器
30a．．．第二探測電容板
30b．．．探測器
30c．．．探測器
32c．．．探測器
40．．．電壓源
50．．．控制模組
52．．．接合墊
54．．．二極體
56．．．開關
58．．．電容器
60．．．電容器
70．．．導電材料
72．．．區域
74．．．塗料
80．．．電容板或探測器
82．．．電容板或探測器
84．．．材料
86．．．材料
圖1A顯示根據本發明的一個觀點之具有可使用電容耦合來予以查詢的裝置之醫藥產品。
圖1B顯示根據本發明的另一個觀點之具有可使用電容耦合來予以查詢的裝置之醫藥產品。
圖1C顯示根據本發明的另一個觀點之具有可使用電容耦合來予以查詢的裝置之醫藥產品。
圖1D顯示根據本發明的另一個觀點之可使用電容耦合來予以探測或查詢的裝置。
圖2顯示根據本發明的一個觀點之圖1A-1D的裝置之電路圖。
圖2A顯示圖2的裝置之二極體橋接器使用。
圖2B顯示經由板及導電材料而與探測器相通訊之圖2的裝置之邏輯單元，其與根據本發明的裝置相關聯。
圖3A顯示根據本發明之具有通過管狀部分，以確認產品真實性及裝置操作的裝置之產品。
圖3B為根據本發明之查詢期間，通過板之間，以確認此產品的真實性之裝置的特定瞬間。
圖4A為根據本發明之與產品相關聯的裝置之上視圖。
圖4B為根據本發明之具有導電複合材料及此裝置的產品之側視圖。
圖5顯示根據本發明之藉由一對探測器來予以查詢之裝置的側視圖。
10a．．．裝置
12a．．．醫藥產品
14a．．．第一金屬或材料
16a．．．第二金屬或材料
20a．．．第一探測電容板
30a．．．第二探測電容板

Claims (18)

  1. 一種可吞食裝置，包含：基板，其包含用於儲存資訊的控制單元及記憶體；第一及第二可吞食板，其係與該基板實體上相關聯，其中，該可吞食裝置配置成通訊地耦接至位於該可吞食裝置外部的探測器，該探測器具有第一及第二探測板而使得資訊可在該可吞食裝置及該探測器間通訊，其中，該第一可吞食板通訊地耦接至位於該可吞食裝置外部的該第一探測板，且該第二可吞食板通訊地耦接至位於該可吞食裝置外部的該第二探測板，以及其中，該探測器係配置為經由該第一及第二探測板電容耦合至對應的該第一及第二可吞食板以電力開啟該可吞食裝置，且驗證該可吞食裝置的功能性。
  2. 如申請專利範圍第1項之可吞食裝置，其中，該第一及第二可吞食板係通訊地耦接至該控制單元。
  3. 如申請專利範圍第1項之可吞食裝置，更包含導電材料區，其與該基板實體上相關聯。
  4. 如申請專利範圍第3項之可吞食裝置，其中，該導電材料區包含該導電材料的微粒與至少一其他材料的混合物。
  5. 如申請專利範圍第4項之可吞食裝置，其中，該至少一其他材料係選自實質上由至少一醫藥材料、至少一輔藥及至少一安慰劑材料所組成的群組。
  6. 如申請專利範圍第1項之可吞食裝置，其中，每一 該第一及第二可吞食板包含與彼此不同的材料。
  7. 如申請專利範圍第1項之可吞食裝置，更包含天線，其耦接至該控制單元，該天線用於與外部裝置通訊。
  8. 如申請專利範圍第7項之可吞食裝置，其中，該天線更包含線圈。
  9. 如申請專利範圍第7項之可吞食裝置，更包含與該天線相關聯的電源。
  10. 一種用以追蹤自產地至目的地之產品的系統，該系統包含：探測器，包含：電源；處理器，係耦接至該電源，用以接收及傳送資訊；及第一探測板和第二探測板，係耦接至該處理器，其中，該電源係藉由該處理器來予以控制，以產生於該第一和該第二板處的輸出；以及可吞食裝置，配置為使用位於該可吞食裝置外部的該探測器來測試，該可吞食裝置包含：基板，其包含用於儲存資訊的控制單元及記憶體；第一及第二可吞食板，其係與該基板實體上相關聯，其中，該可吞食裝置配置成通訊地耦接至該探測器，而使得資訊可在該可吞食裝置及該探測器間通 訊，以及其中，該探測器係配置為經由該第一及第二探測板電容耦合至對應的該第一及第二可吞食板以電力開啟該可吞食裝置，且驗證該可吞食裝置的功能性。
  11. 如申請專利範圍第10項之系統，其中，該第一和該第二探測板係彼此面對，且界定分隔距離的間隙，使得當該可吞食裝置係位於該第一板和該第二板之間而在該界定的間隙中時，該可吞食裝置係與該探測器相通訊。
  12. 如申請專利範圍第10項之系統，其中，該第一和第二探測板係安置於相同平面上，且並排地設置，使得當該可吞食裝置接近該探測器時，該可吞食裝置係與該探測器相通訊。
  13. 如申請專利範圍第10項之系統，其中，探測器更包含管，其具有包含於其中的該第一及第二探測板。
  14. 如申請專利範圍第10項之系統，其中，該第一及第二可吞食板係通訊地耦接至該控制單元。
  15. 如申請專利範圍第10項之系統，更包含導電材料區，其與該基板實體上相關聯。
  16. 如申請專利範圍第10項之系統，其中，該可吞食裝置更包含與該基板實體上相關連的導電材料區域，且其中，該導電材料區包含導電材料的微粒與至少一其他材料的混合物。
  17. 如申請專利範圍第10項之系統，其中，該第一可吞食板及該第二可吞食板包含導電油墨。
  18. 如申請專利範圍第10項之系統，更包含外部裝置，其中該可吞食裝置係配置為與該外部裝置通訊。
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