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EA201691862A3 - Имидазотриазины и имидазопиримидины в качестве ингибиторов киназы - Google Patents

Имидазотриазины и имидазопиримидины в качестве ингибиторов киназы

Info

Publication number
EA201691862A3
EA201691862A3 EA201691862A EA201691862A EA201691862A3 EA 201691862 A3 EA201691862 A3 EA 201691862A3 EA 201691862 A EA201691862 A EA 201691862A EA 201691862 A EA201691862 A EA 201691862A EA 201691862 A3 EA201691862 A3 EA 201691862A3
Authority
EA
Eurasian Patent Office
Prior art keywords
imidazotriasins
imidazopyrimidines
kinase inhibitors
imidazo
inhibitors
Prior art date
Application number
EA201691862A
Other languages
English (en)
Other versions
EA032254B1 (ru
EA201691862A2 (ru
Inventor
Цзиньцун Чжо
Брайан Меткаф
Мэйчжун Сюй
Чуньхун Хэ
Колин Чжан
Дин-Цюань Цянь
Дэвид М. Бернс
Юньлун Ли
Вэньцин Яо
Original Assignee
Инсайт Холдингс Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39166437&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201691862(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Инсайт Холдингс Корпорейшн filed Critical Инсайт Холдингс Корпорейшн
Publication of EA201691862A2 publication Critical patent/EA201691862A2/ru
Publication of EA201691862A3 publication Critical patent/EA201691862A3/ru
Publication of EA032254B1 publication Critical patent/EA032254B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Health & Medical Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Настоящее изобретение относится к имидазо[1,2-b][1,2,4]триазинам и имидазо[1,2-а]пиримидинам, к их фармацевтическим композициям, которые являются ингибиторами киназ, таких как с-Met, и могут быть использованы в лечении рака и других заболеваний, связанных с дисрегуляцией киназных путей.
EA201691862A 2006-11-22 2007-11-19 Имидазотриазины и имидазопиримидины в качестве ингибиторов киназы EA032254B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86084006P 2006-11-22 2006-11-22
US86145906P 2006-11-29 2006-11-29
US95723607P 2007-08-22 2007-08-22

Publications (3)

Publication Number Publication Date
EA201691862A2 EA201691862A2 (ru) 2017-09-29
EA201691862A3 true EA201691862A3 (ru) 2017-12-29
EA032254B1 EA032254B1 (ru) 2019-04-30

Family

ID=39166437

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201691862A EA032254B1 (ru) 2006-11-22 2007-11-19 Имидазотриазины и имидазопиримидины в качестве ингибиторов киназы
EA200970501A EA026126B1 (ru) 2006-11-22 2007-11-19 Имидазотриазины и имидазопиримидины в качестве ингибиторов киназы

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA200970501A EA026126B1 (ru) 2006-11-22 2007-11-19 Имидазотриазины и имидазопиримидины в качестве ингибиторов киназы

Country Status (37)

Country Link
US (7) US7767675B2 (ru)
EP (4) EP3034075B1 (ru)
JP (1) JP5572388B2 (ru)
KR (2) KR101532256B1 (ru)
CN (2) CN101641093B (ru)
AR (1) AR066142A1 (ru)
AU (1) AU2007323725B2 (ru)
BR (1) BRPI0719333A2 (ru)
CA (1) CA2669991C (ru)
CL (1) CL2007003341A1 (ru)
CO (1) CO6210810A2 (ru)
CR (1) CR10841A (ru)
CY (4) CY1116763T1 (ru)
DK (3) DK3034075T3 (ru)
EA (2) EA032254B1 (ru)
EC (1) ECSP099400A (ru)
ES (3) ES2560435T3 (ru)
FR (1) FR22C1060I2 (ru)
GE (1) GEP20125658B (ru)
HK (3) HK1136489A1 (ru)
HR (3) HRP20130106T1 (ru)
HU (2) HUE026659T2 (ru)
IL (4) IL198716A (ru)
LT (1) LT3034075T (ru)
LU (1) LUC00293I2 (ru)
ME (2) ME01507B (ru)
MX (1) MX2009005144A (ru)
MY (2) MY188335A (ru)
NL (1) NL301209I2 (ru)
NO (4) NO346024B1 (ru)
NZ (1) NZ577127A (ru)
PL (3) PL2497470T3 (ru)
PT (3) PT2099447E (ru)
RS (3) RS52677B (ru)
SI (3) SI2497470T1 (ru)
TW (1) TWI429432B (ru)
WO (1) WO2008064157A1 (ru)

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