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SI2432472T1 - 3-(4-(7H-pirolo(2,3-d)pirimidin-4-il)-1H-pirazol-1-il)oktan- ali heptan-nitril kot inhibitorji JAK - Google Patents

3-(4-(7H-pirolo(2,3-d)pirimidin-4-il)-1H-pirazol-1-il)oktan- ali heptan-nitril kot inhibitorji JAK

Info

Publication number
SI2432472T1
SI2432472T1 SI201031943T SI201031943T SI2432472T1 SI 2432472 T1 SI2432472 T1 SI 2432472T1 SI 201031943 T SI201031943 T SI 201031943T SI 201031943 T SI201031943 T SI 201031943T SI 2432472 T1 SI2432472 T1 SI 2432472T1
Authority
SI
Slovenia
Prior art keywords
pyrrolo
pyrazol
pyrimidin
octane
heptane
Prior art date
Application number
SI201031943T
Other languages
English (en)
Inventor
Yun-Long Li
James D Rodgers
Original Assignee
Incyte Holdings Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42246359&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI2432472(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Incyte Holdings Corp filed Critical Incyte Holdings Corp
Publication of SI2432472T1 publication Critical patent/SI2432472T1/sl

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
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    • A61P31/12—Antivirals
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    • A61P31/12—Antivirals
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    • A61P35/00—Antineoplastic agents
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    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Virology (AREA)
  • Diabetes (AREA)
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  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
SI201031943T 2009-05-22 2010-05-21 3-(4-(7H-pirolo(2,3-d)pirimidin-4-il)-1H-pirazol-1-il)oktan- ali heptan-nitril kot inhibitorji JAK SI2432472T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18058209P 2009-05-22 2009-05-22
PCT/US2010/035728 WO2010135621A1 (en) 2009-05-22 2010-05-21 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors
EP10721227.6A EP2432472B1 (en) 2009-05-22 2010-05-21 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors

Publications (1)

Publication Number Publication Date
SI2432472T1 true SI2432472T1 (sl) 2019-11-29

Family

ID=42246359

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201031943T SI2432472T1 (sl) 2009-05-22 2010-05-21 3-(4-(7H-pirolo(2,3-d)pirimidin-4-il)-1H-pirazol-1-il)oktan- ali heptan-nitril kot inhibitorji JAK

Country Status (36)

Country Link
US (3) US8604043B2 (sl)
EP (2) EP3643312A1 (sl)
JP (2) JP6172939B2 (sl)
KR (1) KR20120030447A (sl)
CN (2) CN106967070A (sl)
AR (1) AR076920A1 (sl)
AU (1) AU2010249443B2 (sl)
BR (1) BRPI1012108B8 (sl)
CA (1) CA2761954C (sl)
CL (1) CL2011002955A1 (sl)
CO (1) CO6470876A2 (sl)
CR (1) CR20110621A (sl)
CY (1) CY1122425T1 (sl)
DK (1) DK2432472T3 (sl)
EA (1) EA020494B1 (sl)
EC (1) ECSP11011534A (sl)
ES (1) ES2761300T3 (sl)
HR (1) HRP20192203T1 (sl)
HU (1) HUE046493T2 (sl)
IL (1) IL216359A (sl)
LT (1) LT2432472T (sl)
ME (1) ME03556B (sl)
MX (1) MX2011012262A (sl)
MY (1) MY161416A (sl)
NZ (1) NZ596374A (sl)
PE (1) PE20120371A1 (sl)
PL (1) PL2432472T3 (sl)
PT (1) PT2432472T (sl)
RS (1) RS59632B1 (sl)
SG (2) SG10201402492TA (sl)
SI (1) SI2432472T1 (sl)
SM (1) SMT201900698T1 (sl)
TW (1) TWI484962B (sl)
UA (1) UA106078C2 (sl)
WO (1) WO2010135621A1 (sl)
ZA (1) ZA201108541B (sl)

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UA111854C2 (uk) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak
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US9623029B2 (en) 2017-04-18
ES2761300T3 (es) 2020-05-19
DK2432472T3 (da) 2019-11-18
EP2432472A1 (en) 2012-03-28
CO6470876A2 (es) 2012-06-29
HUE046493T2 (hu) 2020-03-30
KR20120030447A (ko) 2012-03-28
EA020494B1 (ru) 2014-11-28
AR076920A1 (es) 2011-07-20
AU2010249443B2 (en) 2015-08-13
PL2432472T3 (pl) 2020-03-31
EP2432472B1 (en) 2019-10-02
EP3643312A1 (en) 2020-04-29
SG10201402492TA (en) 2014-08-28
BRPI1012108B8 (pt) 2021-05-25
RS59632B1 (sr) 2020-01-31

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