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BRPI1012108B8 - composto 3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]octa no- ou heptano-nitrila, sua composição, seus usos e processo para preparar um sal de ácido fosfórico - Google Patents

composto 3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]octa no- ou heptano-nitrila, sua composição, seus usos e processo para preparar um sal de ácido fosfórico

Info

Publication number
BRPI1012108B8
BRPI1012108B8 BRPI1012108A BRPI1012108A BRPI1012108B8 BR PI1012108 B8 BRPI1012108 B8 BR PI1012108B8 BR PI1012108 A BRPI1012108 A BR PI1012108A BR PI1012108 A BRPI1012108 A BR PI1012108A BR PI1012108 B8 BRPI1012108 B8 BR PI1012108B8
Authority
BR
Brazil
Prior art keywords
pyrrolo
pyrazol
pyrimidin
octane
heptane
Prior art date
Application number
BRPI1012108A
Other languages
English (en)
Inventor
D Rodgers James
Li Yun-Long
Original Assignee
Incyte Corp
Incyte Holdings Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42246359&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI1012108(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Incyte Corp, Incyte Holdings Corp filed Critical Incyte Corp
Publication of BRPI1012108A2 publication Critical patent/BRPI1012108A2/pt
Publication of BRPI1012108B1 publication Critical patent/BRPI1012108B1/pt
Publication of BRPI1012108B8 publication Critical patent/BRPI1012108B8/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
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    • A61P35/00—Antineoplastic agents
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    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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Abstract

composto 3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]octano- ou heptano-nitrila, sua composição, seus usos e processo para preparar um sal de ácido fosfórico. a presente invenção refere-se aos inibidores de janus cinase (jak) 3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]octanonitrila ou 3-[4-(7h-pirrolo [2,3-d]pirimidin-4-il)-1h-pirazol-1-il]heptanonitrila, bem como suas composições e métodos de uso, que é útil no tratamento de doenças associadas a jak incluindo, por exemplo, distúrbios inflamatórios e autoimunes, distúrbios da pele, câncer, e outras doenças.
BRPI1012108A 2009-05-22 2010-05-21 composto 3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]octa no- ou heptano-nitrila, sua composição, seus usos e processo para preparar um sal de ácido fosfórico BRPI1012108B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18058209P 2009-05-22 2009-05-22
US61/180,582 2009-05-22
PCT/US2010/035728 WO2010135621A1 (en) 2009-05-22 2010-05-21 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors

Publications (3)

Publication Number Publication Date
BRPI1012108A2 BRPI1012108A2 (pt) 2016-03-29
BRPI1012108B1 BRPI1012108B1 (pt) 2020-08-25
BRPI1012108B8 true BRPI1012108B8 (pt) 2021-05-25

Family

ID=42246359

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1012108A BRPI1012108B8 (pt) 2009-05-22 2010-05-21 composto 3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]octa no- ou heptano-nitrila, sua composição, seus usos e processo para preparar um sal de ácido fosfórico

Country Status (36)

Country Link
US (3) US8604043B2 (pt)
EP (2) EP3643312A1 (pt)
JP (2) JP6172939B2 (pt)
KR (1) KR20120030447A (pt)
CN (2) CN106967070A (pt)
AR (1) AR076920A1 (pt)
AU (1) AU2010249443B2 (pt)
BR (1) BRPI1012108B8 (pt)
CA (1) CA2761954C (pt)
CL (1) CL2011002955A1 (pt)
CO (1) CO6470876A2 (pt)
CR (1) CR20110621A (pt)
CY (1) CY1122425T1 (pt)
DK (1) DK2432472T3 (pt)
EA (1) EA020494B1 (pt)
EC (1) ECSP11011534A (pt)
ES (1) ES2761300T3 (pt)
HR (1) HRP20192203T1 (pt)
HU (1) HUE046493T2 (pt)
IL (1) IL216359A (pt)
LT (1) LT2432472T (pt)
ME (1) ME03556B (pt)
MX (1) MX2011012262A (pt)
MY (1) MY161416A (pt)
NZ (1) NZ596374A (pt)
PE (1) PE20120371A1 (pt)
PL (1) PL2432472T3 (pt)
PT (1) PT2432472T (pt)
RS (1) RS59632B1 (pt)
SG (2) SG176111A1 (pt)
SI (1) SI2432472T1 (pt)
SM (1) SMT201900698T1 (pt)
TW (1) TWI484962B (pt)
UA (1) UA106078C2 (pt)
WO (1) WO2010135621A1 (pt)
ZA (1) ZA201108541B (pt)

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EA020494B1 (ru) 2014-11-28
JP6302442B2 (ja) 2018-03-28
SG10201402492TA (en) 2014-08-28
US9216984B2 (en) 2015-12-22
CR20110621A (es) 2012-02-09
CN102458411A (zh) 2012-05-16
PE20120371A1 (es) 2012-05-17
EP2432472B1 (en) 2019-10-02
SMT201900698T1 (it) 2020-01-14
ES2761300T3 (es) 2020-05-19
IL216359A (en) 2016-09-29
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