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DE69233482D1 - Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen - Google Patents

Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen

Info

Publication number
DE69233482D1
DE69233482D1 DE69233482T DE69233482T DE69233482D1 DE 69233482 D1 DE69233482 D1 DE 69233482D1 DE 69233482 T DE69233482 T DE 69233482T DE 69233482 T DE69233482 T DE 69233482T DE 69233482 D1 DE69233482 D1 DE 69233482D1
Authority
DE
Germany
Prior art keywords
immunogenicity
reducing
variable domains
antibody variable
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69233482T
Other languages
English (en)
Other versions
DE69233482T2 (de
Inventor
Eduardo A Padlan
Mark, Iii
Bruce L Daugherty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
National Institutes of Health NIH
Original Assignee
Merck and Co Inc
National Institutes of Health NIH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc, National Institutes of Health NIH filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE69233482D1 publication Critical patent/DE69233482D1/de
Publication of DE69233482T2 publication Critical patent/DE69233482T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/461Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/467Igs with modifications in the FR-residues only
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE1992633482 1991-05-17 1992-05-12 Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen Expired - Lifetime DE69233482T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70221791A 1991-05-17 1991-05-17
US702217 1991-05-17

Publications (2)

Publication Number Publication Date
DE69233482D1 true DE69233482D1 (de) 2005-03-31
DE69233482T2 DE69233482T2 (de) 2006-01-12

Family

ID=24820297

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1992633482 Expired - Lifetime DE69233482T2 (de) 1991-05-17 1992-05-12 Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen

Country Status (4)

Country Link
EP (1) EP0519596B1 (de)
JP (1) JP3426615B2 (de)
CA (1) CA2068593C (de)
DE (1) DE69233482T2 (de)

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* Cited by examiner, † Cited by third party
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DE69233482T2 (de) 2006-01-12
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JPH09191900A (ja) 1997-07-29
EP0519596A1 (de) 1992-12-23
EP0519596B1 (de) 2005-02-23

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