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CL2018002193A1 - Anticuerpos modificados de unión a fcrn humano y métodos de utilización (divisional solicitud 201503126) - Google Patents

Anticuerpos modificados de unión a fcrn humano y métodos de utilización (divisional solicitud 201503126)

Info

Publication number
CL2018002193A1
CL2018002193A1 CL2018002193A CL2018002193A CL2018002193A1 CL 2018002193 A1 CL2018002193 A1 CL 2018002193A1 CL 2018002193 A CL2018002193 A CL 2018002193A CL 2018002193 A CL2018002193 A CL 2018002193A CL 2018002193 A1 CL2018002193 A1 CL 2018002193A1
Authority
CL
Chile
Prior art keywords
methods
divisional application
fcrn binding
human fcrn
binding antibodies
Prior art date
Application number
CL2018002193A
Other languages
English (en)
Inventor
Matthias Rueth
Tilman Schlothauer
Joerg Thomas Regula
Wolfgang Schaefer
Guido Hartmann
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CL2018002193A1 publication Critical patent/CL2018002193A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

EN LA PRESENTE MEMORIA SE INFORMA SOBRE LA UTILIZACIÓN DE UN ANTICUERPO QUE COMPRENDE UNA REGIÓN DE FC CON UNA UNIÓN A FCRN QUE HA SIDO ANULADA, PARA EL TRANSPORTE DE UN LIGANDO DE RECEPTOR SOLUBLE DESDE EL OJO A TRAVÉS DE LA BARRERA HEMATO-OCULAR Y A LA CIRCULACIÓN SANGUÍNEA.
CL2018002193A 2013-04-29 2018-08-09 Anticuerpos modificados de unión a fcrn humano y métodos de utilización (divisional solicitud 201503126) CL2018002193A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13165744 2013-04-29
EP14151316 2014-01-15
CL2015003126A CL2015003126A1 (es) 2013-04-29 2015-10-23 Anticuerpos modificados de unión a fcrn humano y métodos de utilización.

Publications (1)

Publication Number Publication Date
CL2018002193A1 true CL2018002193A1 (es) 2018-11-23

Family

ID=50678163

Family Applications (3)

Application Number Title Priority Date Filing Date
CL2015003126A CL2015003126A1 (es) 2013-04-29 2015-10-23 Anticuerpos modificados de unión a fcrn humano y métodos de utilización.
CL2018002194A CL2018002194A1 (es) 2013-04-29 2018-08-09 Anticuerpos modificados de unión a fcrn humano y métodos de utilización (divisional solicitud 201503126)
CL2018002193A CL2018002193A1 (es) 2013-04-29 2018-08-09 Anticuerpos modificados de unión a fcrn humano y métodos de utilización (divisional solicitud 201503126)

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CL2015003126A CL2015003126A1 (es) 2013-04-29 2015-10-23 Anticuerpos modificados de unión a fcrn humano y métodos de utilización.
CL2018002194A CL2018002194A1 (es) 2013-04-29 2018-08-09 Anticuerpos modificados de unión a fcrn humano y métodos de utilización (divisional solicitud 201503126)

Country Status (23)

Country Link
US (2) US11091541B2 (es)
EP (2) EP2992012B1 (es)
JP (3) JP2016528167A (es)
KR (2) KR20210094669A (es)
CN (1) CN105143262A (es)
AU (3) AU2014261630B2 (es)
BR (1) BR112015027385A2 (es)
CA (1) CA2904806C (es)
CL (3) CL2015003126A1 (es)
CR (1) CR20150512A (es)
EA (1) EA201501063A1 (es)
ES (1) ES2746136T3 (es)
HK (1) HK1213578A1 (es)
IL (1) IL241787B (es)
MX (1) MX365787B (es)
MY (1) MY172430A (es)
PE (2) PE20190920A1 (es)
PH (1) PH12015502470A1 (es)
PL (1) PL2992012T3 (es)
SG (2) SG10201800492PA (es)
TW (1) TWI747803B (es)
UA (1) UA118029C2 (es)
WO (1) WO2014177460A1 (es)

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JP2022062120A (ja) 2022-04-19
EP3628685A1 (en) 2020-04-01
CN105143262A (zh) 2015-12-09
CR20150512A (es) 2015-11-19
BR112015027385A2 (pt) 2017-08-29
SG11201508911PA (en) 2015-11-27
SG10201800492PA (en) 2018-03-28
JP7642574B2 (ja) 2025-03-10
AU2020201429B2 (en) 2022-06-16
CA2904806C (en) 2021-11-23
TWI747803B (zh) 2021-12-01
ES2746136T3 (es) 2020-03-04
HK1213578A1 (zh) 2016-07-08
JP7426190B2 (ja) 2024-02-01
MX2015015061A (es) 2016-02-11
AU2020201429A1 (en) 2020-03-19
AU2014261630B2 (en) 2019-05-09
US20160159894A1 (en) 2016-06-09
EA201501063A1 (ru) 2016-05-31
WO2014177460A1 (en) 2014-11-06
JP2018197264A (ja) 2018-12-13
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US11091541B2 (en) 2021-08-17

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