|
DE60122286T2
(de)
|
2000-02-11 |
2007-08-02 |
Merck Patent Gmbh |
Steigerung der zirkulierenden halbwertzeit von auf antikörpern basierenden fusionsproteinen
|
|
BR0207854A
(pt)
|
2001-03-07 |
2004-08-24 |
Merck Patent Gmbh |
Tecnologia de expressão para proteìnas contendo uma porção de anticorpo de isotipo hìbrido
|
|
WO2002079415A2
(en)
|
2001-03-30 |
2002-10-10 |
Lexigen Pharmaceuticals Corp. |
Reducing the immunogenicity of fusion proteins
|
|
HUP0400284A3
(en)
|
2001-05-03 |
2012-09-28 |
Merck Patent Gmbh |
Recombinant tumor specific antibody and use thereof
|
|
PL206975B1
(pl)
|
2001-12-04 |
2010-10-29 |
Merck Patent Gmbh |
Immunocytokiny o modulowanej selektywności oraz ich zastosowanie
|
|
CA2872136C
(en)
|
2002-07-18 |
2017-06-20 |
Merus B.V. |
Recombinant production of mixtures of antibodies
|
|
USRE47770E1
(en)
|
2002-07-18 |
2019-12-17 |
Merus N.V. |
Recombinant production of mixtures of antibodies
|
|
BRPI0418286A
(pt)
|
2003-12-30 |
2007-05-02 |
Merck Patent Gmbh |
proteìnas de fusão de il-7
|
|
CA2551916C
(en)
|
2003-12-31 |
2014-04-29 |
Merck Patent Gesellschaft Mit Beschraenkter Haftung |
Fc-erythropoietin fusion protein with improved pharmacokinetics
|
|
US7670595B2
(en)
|
2004-06-28 |
2010-03-02 |
Merck Patent Gmbh |
Fc-interferon-beta fusion proteins
|
|
WO2006106905A1
(ja)
|
2005-03-31 |
2006-10-12 |
Chugai Seiyaku Kabushiki Kaisha |
会合制御によるポリペプチド製造方法
|
|
PT1999154E
(pt)
|
2006-03-24 |
2013-01-24 |
Merck Patent Gmbh |
Domínios proteicos heterodiméricos modificados
|
|
JP5144499B2
(ja)
|
2006-03-31 |
2013-02-13 |
中外製薬株式会社 |
二重特異性抗体を精製するための抗体改変方法
|
|
AU2007305443B2
(en)
|
2006-09-29 |
2012-08-23 |
Oncomed Pharmaceuticals, Inc. |
Compositions and methods for diagnosing and treating cancer
|
|
MX2009010282A
(es)
|
2007-03-29 |
2009-10-12 |
Genmab As |
Anticuerpos biespecificos y metodos para su produccion.
|
|
US20090162359A1
(en)
|
2007-12-21 |
2009-06-25 |
Christian Klein |
Bivalent, bispecific antibodies
|
|
US9266967B2
(en)
|
2007-12-21 |
2016-02-23 |
Hoffmann-La Roche, Inc. |
Bivalent, bispecific antibodies
|
|
AU2015202560B2
(en)
*
|
2008-01-07 |
2017-06-15 |
Amgen Inc. |
Method for Making Antibody Fc-Heterodimeric Molecules Using Electrostatic Steering Effects
|
|
SI2235064T1
(sl)
|
2008-01-07 |
2016-04-29 |
Amgen Inc. |
Metoda za izdelavo heterodimernih molekul - protitelesa fc z uporabo elektrostatičnih usmerjevalnih učinkov
|
|
BRPI0910484A2
(pt)
*
|
2008-04-25 |
2018-03-27 |
Merck Patent Gmbh |
esqueletos artificiais de proteína
|
|
CN102076355B
(zh)
|
2008-04-29 |
2014-05-07 |
Abbvie公司 |
双重可变结构域免疫球蛋白及其用途
|
|
TW201008580A
(en)
|
2008-06-03 |
2010-03-01 |
Abbott Lab |
Dual variable domain immunoglobulin and uses thereof
|
|
KR101431318B1
(ko)
*
|
2009-04-02 |
2014-08-20 |
로슈 글리카트 아게 |
전장 항체 및 단일쇄 ｆａｂ 단편을 포함하는 다중특이성 항체
|
|
JP5616428B2
(ja)
|
2009-04-07 |
2014-10-29 |
ロシュ グリクアート アクチェンゲゼルシャフト |
三価の二重特異性抗体
|
|
EA201171259A1
(ru)
|
2009-04-22 |
2012-05-30 |
Мерк Патент Гмбх |
Антительные гибридные белки с модифицированными сайтами связывания fcrn
|
|
WO2010129304A2
(en)
|
2009-04-27 |
2010-11-11 |
Oncomed Pharmaceuticals, Inc. |
Method for making heteromultimeric molecules
|
|
US9676845B2
(en)
|
2009-06-16 |
2017-06-13 |
Hoffmann-La Roche, Inc. |
Bispecific antigen binding proteins
|
|
AU2010270844A1
(en)
|
2009-07-08 |
2011-12-22 |
Amgen Inc. |
Design of stable and aggregation free antibody Fc molecules through CH3 domain interface engineering
|
|
WO2011028952A1
(en)
|
2009-09-02 |
2011-03-10 |
Xencor, Inc. |
Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
|
|
CA2781519A1
(en)
|
2009-09-16 |
2011-03-24 |
Genentech, Inc. |
Coiled coil and/or tether containing protein complexes and uses thereof
|
|
EP3072526B1
(en)
|
2009-10-16 |
2018-09-26 |
Oncomed Pharmaceuticals, Inc. |
Therapeutic combination and use of dll4 antagonist antibodies and anti-hypertensive agents
|
|
TW201138821A
(en)
|
2010-03-26 |
2011-11-16 |
Roche Glycart Ag |
Bispecific antibodies
|
|
ES2989108T3
(es)
|
2010-04-20 |
2024-11-25 |
Genmab As |
Proteínas que contienen FC de anticuerpos heterodiméricos y métodos para producir las mismas
|
|
UY33492A
(es)
|
2010-07-09 |
2012-01-31 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
AU2011283694B2
(en)
|
2010-07-29 |
2017-04-13 |
Xencor, Inc. |
Antibodies with modified isoelectric points
|
|
PE20131412A1
(es)
|
2010-08-03 |
2014-01-19 |
Abbvie Inc |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
EP2609111B1
(en)
|
2010-08-24 |
2017-11-01 |
F. Hoffmann-La Roche AG |
Bispecific antibodies comprising a disulfide stabilized-fv fragment
|
|
US8551479B2
(en)
|
2010-09-10 |
2013-10-08 |
Oncomed Pharmaceuticals, Inc. |
Methods for treating melanoma
|
|
AU2011325833C1
(en)
*
|
2010-11-05 |
2017-07-13 |
Zymeworks Bc Inc. |
Stable heterodimeric antibody design with mutations in the Fc domain
|
|
CA2817015A1
(en)
*
|
2010-11-09 |
2012-05-18 |
Altimab Therapeutics, Inc. |
Protein complexes for antigen binding and methods of use
|
|
MX349057B
(es)
|
2010-11-30 |
2017-07-07 |
Chugai Pharmaceutical Co Ltd |
Agente terapeutico que induce citotoxicidad.
|
|
JP5766296B2
(ja)
|
2010-12-23 |
2015-08-19 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
ポリペプチド−ポリヌクレオチド複合体、およびエフェクター成分の標的化された送達におけるその使用
|
|
WO2012116927A1
(en)
|
2011-02-28 |
2012-09-07 |
F. Hoffmann-La Roche Ag |
Monovalent antigen binding proteins
|
|
MX341921B
(es)
|
2011-02-28 |
2016-09-07 |
Hoffmann La Roche |
Proteinas de union a antigeno.
|
|
EP2688909A2
(en)
*
|
2011-03-25 |
2014-01-29 |
Glenmark Pharmaceuticals S.A. |
Hetero-dimeric immunoglobulins
|
|
DK2697257T3
(en)
|
2011-04-13 |
2017-01-30 |
Bristol Myers Squibb Co |
FC FUSION PROTEINS INCLUDING UNKNOWN LINKERS OR EVENTS
|
|
CA2832389A1
(en)
|
2011-04-20 |
2012-10-26 |
Genmab A/S |
Bispecific antibodies against her2 and cd3
|
|
EP2699260B1
(en)
|
2011-04-20 |
2024-11-20 |
Genmab A/S |
Bispecifc antibodies against her2
|
|
JP6400470B2
(ja)
*
|
2011-05-16 |
2018-10-03 |
ジェネロン（シャンハイ）コーポレイション リミテッド |
多重特異性Ｆａｂ融合タンパク質および使用法
|
|
UA117901C2
(uk)
|
2011-07-06 |
2018-10-25 |
Ґенмаб Б.В. |
Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування
|
|
CA2844540C
(en)
|
2011-08-23 |
2018-10-16 |
Roche Glycart Ag |
Bispecific antibodies specific for t-cell activating antigens and a tumor antigen and methods of use
|
|
GB201116092D0
(en)
|
2011-09-16 |
2011-11-02 |
Bioceros B V |
Antibodies and uses thereof
|
|
EP2758073B1
(en)
|
2011-09-23 |
2018-10-31 |
OncoMed Pharmaceuticals, Inc. |
Vegf/dll4 binding agents and uses thereof
|
|
US10851178B2
(en)
|
2011-10-10 |
2020-12-01 |
Xencor, Inc. |
Heterodimeric human IgG1 polypeptides with isoelectric point modifications
|
|
US12466897B2
(en)
|
2011-10-10 |
2025-11-11 |
Xencor, Inc. |
Heterodimeric human IgG1 polypeptides with isoelectric point modifications
|
|
SG10201805291TA
(en)
|
2011-10-27 |
2018-08-30 |
Genmab As |
Production of heterodimeric proteins
|
|
ES2732712T3
(es)
*
|
2011-10-31 |
2019-11-25 |
Chugai Pharmaceutical Co Ltd |
Molécula de unión a antígeno que tiene una conjugación regulada entre la cadena pesada y la cadena ligera
|
|
AU2012332021B8
(en)
|
2011-11-04 |
2017-10-12 |
Zymeworks Bc Inc. |
Stable heterodimeric antibody design with mutations in the Fc domain
|
|
JP2014533249A
(ja)
|
2011-11-07 |
2014-12-11 |
メディミューン，エルエルシー |
多重特異性を持つ多価結合タンパク質およびその使用
|
|
DK2794905T3
(da)
|
2011-12-20 |
2020-07-06 |
Medimmune Llc |
Modificerede polypeptider til bispecifikke antistofgrundstrukturer
|
|
EP2812357B1
(en)
|
2012-02-10 |
2020-11-04 |
F.Hoffmann-La Roche Ag |
Single-chain antibodies and other heteromultimers
|
|
CN114163530B
(zh)
*
|
2012-04-20 |
2025-04-29 |
美勒斯公司 |
用于产生免疫球蛋白样分子的方法和手段
|
|
US9212227B2
(en)
|
2012-04-30 |
2015-12-15 |
Janssen Biotech, Inc. |
ST2L antibody antagonists for the treatment of ST2L-mediated inflammatory pulmonary conditions
|
|
US9499634B2
(en)
|
2012-06-25 |
2016-11-22 |
Zymeworks Inc. |
Process and methods for efficient manufacturing of highly pure asymmetric antibodies in mammalian cells
|
|
RU2639287C2
(ru)
|
2012-06-27 |
2017-12-20 |
Ф. Хоффманн-Ля Рош Аг |
Способ отбора и получения высокоселективных и мультиспецифичных нацеливающих групп с заданными свойствами, включающих по меньшей мере две различные связывающие группировки, и их применения
|
|
KR20150030744A
(ko)
|
2012-06-27 |
2015-03-20 |
에프. 호프만-라 로슈 아게 |
표적에 특이적으로 결합하는 하나 이상의 결합 단위를 포함하는 항체 Ｆｃ－영역 접합체의 제조 방법 및 그의 용도
|
|
BR112015000167B1
(pt)
|
2012-07-06 |
2021-11-23 |
Genmab B.V. |
Proteína dimérica, proteína, composição, kit de partes e seus usos, bem como método para aumentar a oligomerização em solução de uma proteína dimérica compreendendo um primeiro e segundo polipeptídeo, cada um compreendendo pelo menos as regiões ch2 e ch3 de uma cadeia pesada de igg1 humana e proteína dimérica variante
|
|
EP3632462A1
(en)
|
2012-07-06 |
2020-04-08 |
Genmab B.V. |
Dimeric protein with triple mutations
|
|
CA2886036A1
(en)
|
2012-09-25 |
2014-04-03 |
Glenmark Pharmaceuticals S.A. |
Purification of hetero-dimeric immunoglobulins
|
|
SG10201705787VA
(en)
|
2012-09-27 |
2017-08-30 |
Merus Nv |
BISPECIFIC IgG ANTIBODIES AS T CELL ENGAGERS
|
|
EP2904093B1
(en)
|
2012-10-03 |
2019-04-10 |
Zymeworks Inc. |
Methods of quantitating heavy and light chain polypeptide pairs
|
|
JP6273205B2
(ja)
|
2012-10-05 |
2018-01-31 |
協和発酵キリン株式会社 |
ヘテロダイマータンパク質組成物
|
|
EP2904016B1
(en)
|
2012-10-08 |
2018-11-14 |
Roche Glycart AG |
Fc-free antibodies comprising two fab-fragments and methods of use
|
|
CA2887825A1
(en)
|
2012-10-23 |
2014-05-01 |
The Board Of Regents Of The University Of Texas System |
Engineered igg fc domains
|
|
EP2914961A4
(en)
|
2012-10-31 |
2016-04-20 |
Oncomed Pharm Inc |
PROCESS AND MONITOR THE TREATMENT WITH A DLL4 ANTAGONIST
|
|
WO2014079000A1
(en)
*
|
2012-11-21 |
2014-05-30 |
Wuhan Yzy Biopharma Co., Ltd. |
Bispecific antibody
|
|
MX385344B
(es)
|
2012-11-28 |
2025-03-18 |
Zymeworks Bc Inc |
Pares de cadena pesada-cadena ligera de inmunoglobulina modificados genéticamente y usos de estos.
|
|
US9914785B2
(en)
|
2012-11-28 |
2018-03-13 |
Zymeworks Inc. |
Engineered immunoglobulin heavy chain-light chain pairs and uses thereof
|
|
EA201500741A1
(ru)
|
2013-01-10 |
2016-01-29 |
Генмаб Б.В. |
ВАРИАНТЫ Fc-ОБЛАСТИ IGG1 ЧЕЛОВЕКА И ИХ ПРИМЕНЕНИЕ
|
|
US9701759B2
(en)
|
2013-01-14 |
2017-07-11 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US9605084B2
(en)
|
2013-03-15 |
2017-03-28 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US10487155B2
(en)
|
2013-01-14 |
2019-11-26 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US10131710B2
(en)
|
2013-01-14 |
2018-11-20 |
Xencor, Inc. |
Optimized antibody variable regions
|
|
US10738132B2
(en)
|
2013-01-14 |
2020-08-11 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US11053316B2
(en)
|
2013-01-14 |
2021-07-06 |
Xencor, Inc. |
Optimized antibody variable regions
|
|
US10968276B2
(en)
|
2013-03-12 |
2021-04-06 |
Xencor, Inc. |
Optimized anti-CD3 variable regions
|
|
US9738722B2
(en)
|
2013-01-15 |
2017-08-22 |
Xencor, Inc. |
Rapid clearance of antigen complexes using novel antibodies
|
|
EP3744728A1
(en)
|
2013-02-12 |
2020-12-02 |
Bristol-Myers Squibb Company |
Tangential flow filtration based protein refolding methods
|
|
ES2870802T3
(es)
|
2013-02-12 |
2021-10-27 |
Bristol Myers Squibb Co |
Métodos de replegado de proteínas a elevado pH
|
|
MX2015010350A
(es)
|
2013-02-26 |
2015-10-29 |
Roche Glycart Ag |
Moleculas de union a antigeno biespecificas que activan la celula t.
|
|
EP2961771B1
(en)
|
2013-02-26 |
2020-01-01 |
Roche Glycart AG |
Bispecific t cell activating antigen binding molecules specific to cd3 and cea
|
|
KR20150128849A
(ko)
|
2013-03-15 |
2015-11-18 |
얀센 바이오테크 인코포레이티드 |
인터페론 알파 및 오메가 항체 길항제
|
|
US10858417B2
(en)
|
2013-03-15 |
2020-12-08 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US10106624B2
(en)
|
2013-03-15 |
2018-10-23 |
Xencor, Inc. |
Heterodimeric proteins
|
|
EP3421495A3
(en)
|
2013-03-15 |
2019-05-15 |
Xencor, Inc. |
Modulation of t cells with bispecific antibodies and fc fusions
|
|
US10519242B2
(en)
|
2013-03-15 |
2019-12-31 |
Xencor, Inc. |
Targeting regulatory T cells with heterodimeric proteins
|
|
EP2976361B1
(en)
|
2013-03-18 |
2018-07-18 |
BiocerOX Products B.V. |
Humanized anti-cd134 (ox40) antibodies and uses thereof
|
|
CN118561989A
(zh)
|
2013-04-29 |
2024-08-30 |
豪夫迈·罗氏有限公司 |
Fc-受体结合的修饰的非对称抗体及使用方法
|
|
TWI653243B
(zh)
|
2013-04-29 |
2019-03-11 |
赫孚孟拉羅股份公司 |
遏止ＦｃＲｎ結合之抗ＩＧＦ－１Ｒ抗體及其治療血管性眼疾之用途
|
|
HK1213578A1
(zh)
|
2013-04-29 |
2016-07-08 |
豪夫迈‧罗氏有限公司 |
结合人fcrn的修饰的抗体和使用方法
|
|
DK3016681T5
(da)
|
2013-07-05 |
2020-05-04 |
Genmab As |
Humaniserede eller kimære CD3-antistoffer
|
|
SG10201803449VA
(en)
|
2013-09-27 |
2018-05-30 |
Chugai Pharmaceutical Co Ltd |
Method for producing polypeptide heteromultimer
|
|
KR20160044060A
(ko)
|
2013-10-11 |
2016-04-22 |
에프. 호프만-라 로슈 아게 |
다중특이적 도메인 교환된 통상의 가변 경쇄 항체
|
|
SI3065774T1
(sl)
|
2013-11-06 |
2021-11-30 |
Janssen Biotech, Inc. |
Protitelesa proti CCL17
|
|
WO2015077891A1
(en)
|
2013-11-27 |
2015-06-04 |
Zymeworks Inc. |
Bispecific antigen-binding constructs targeting her2
|
|
EP3192812B1
(en)
|
2013-12-17 |
2020-05-27 |
Genentech, Inc. |
Anti-cd3 antibodies and methods of use
|
|
HRP20200384T1
(hr)
|
2013-12-20 |
2020-06-12 |
F. Hoffmann - La Roche Ag |
Humanizirana anti-tau(ps422) protutijela i načini uporabe
|
|
US10561737B2
(en)
|
2014-01-03 |
2020-02-18 |
Hoffmann-La Roche Inc. |
Bispecific anti-hapten/anti-blood brain barrier receptor antibodies, complexes thereof and their use as blood brain barrier shuttles
|
|
RU2694659C2
(ru)
|
2014-01-06 |
2019-07-16 |
Ф. Хоффманн-Ля Рош Аг |
Одновалентные модули-переносчики через гематоэнцефалический барьер
|
|
CA2931986A1
(en)
|
2014-01-15 |
2015-07-23 |
F. Hoffmann-La Roche Ag |
Fc-region variants with modified fcrn- and maintained protein a-binding properties
|
|
JOP20200094A1
(ar)
|
2014-01-24 |
2017-06-16 |
Dana Farber Cancer Inst Inc |
جزيئات جسم مضاد لـ pd-1 واستخداماتها
|
|
JOP20200096A1
(ar)
|
2014-01-31 |
2017-06-16 |
Children’S Medical Center Corp |
جزيئات جسم مضاد لـ tim-3 واستخداماتها
|
|
SG11201607104RA
(en)
|
2014-02-28 |
2016-09-29 |
Merus Nv |
Antibody that binds erbb-2 and erbb-3
|
|
US9732154B2
(en)
|
2014-02-28 |
2017-08-15 |
Janssen Biotech, Inc. |
Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia
|
|
ES2816624T3
(es)
|
2014-02-28 |
2021-04-05 |
Merus Nv |
Anticuerpos que se unen a EGFR y ERBB3
|
|
LT3116909T
(lt)
|
2014-03-14 |
2020-02-10 |
Novartis Ag |
Antikūno molekulės prieš lag-3 ir jų panaudojimas
|
|
CN106163547A
(zh)
|
2014-03-15 |
2016-11-23 |
诺华股份有限公司 |
使用嵌合抗原受体治疗癌症
|
|
LT3122781T
(lt)
|
2014-03-28 |
2020-03-25 |
Xencor, Inc. |
Bispecifiniai antikūnai, kurie jungiasi prie cd38 ir cd3
|
|
CN106164288A
(zh)
|
2014-04-02 |
2016-11-23 |
豪夫迈·罗氏有限公司 |
检测多特异性抗体轻链错配的方法
|
|
UA117289C2
(uk)
|
2014-04-02 |
2018-07-10 |
Ф. Хоффманн-Ля Рош Аг |
Мультиспецифічне антитіло
|
|
MY194892A
(en)
|
2014-04-07 |
2022-12-22 |
Chugai Pharmaceutical Co Ltd |
Immunoactivating antigen-binding molecule
|
|
CN106459954A
(zh)
|
2014-05-13 |
2017-02-22 |
中外制药株式会社 |
用于具有免疫抑制功能的细胞的t细胞重定向的抗原结合分子
|
|
HK1231490A1
(zh)
|
2014-05-28 |
2017-12-22 |
Zymeworks, Inc. |
修饰的抗原结合多肽构建体及其用途
|
|
TWI713453B
(zh)
|
2014-06-23 |
2020-12-21 |
美商健生生物科技公司 |
干擾素α及ω抗體拮抗劑
|
|
AR100978A1
(es)
|
2014-06-26 |
2016-11-16 |
Hoffmann La Roche |
LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS
|
|
MX384037B
(es)
|
2014-06-26 |
2025-03-14 |
Hoffmann La Roche |
Anticuerpos anti-bromodesoxiuridina(brdu) y metodos de uso.
|
|
PE20170286A1
(es)
|
2014-07-01 |
2017-03-30 |
Pfizer |
Diacuerpos heterodimericos biespecificos y sus usos
|
|
PT3169706T
(pt)
|
2014-07-11 |
2020-03-13 |
Genmab As |
Anticorpos que se ligam a axl
|
|
EP3172237A2
(en)
|
2014-07-21 |
2017-05-31 |
Novartis AG |
Treatment of cancer using humanized anti-bcma chimeric antigen receptor
|
|
BR112017001242A2
(pt)
|
2014-07-21 |
2017-12-05 |
Novartis Ag |
tratamento de câncer usando um receptor antigênico quimérico a cd33
|
|
WO2016014530A1
(en)
|
2014-07-21 |
2016-01-28 |
Novartis Ag |
Combinations of low, immune enhancing. doses of mtor inhibitors and cars
|
|
WO2016014553A1
(en)
|
2014-07-21 |
2016-01-28 |
Novartis Ag |
Sortase synthesized chimeric antigen receptors
|
|
EP3660042B1
(en)
|
2014-07-31 |
2023-01-11 |
Novartis AG |
Subset-optimized chimeric antigen receptor-containing t-cells
|
|
EP2982692A1
(en)
|
2014-08-04 |
2016-02-10 |
EngMab AG |
Bispecific antibodies against CD3epsilon and BCMA
|
|
PE20170263A1
(es)
|
2014-08-04 |
2017-03-30 |
Hoffmann La Roche |
Moleculas biespecificas de union a antigeno activadoras de celulas t
|
|
US10851149B2
(en)
|
2014-08-14 |
2020-12-01 |
The Trustees Of The University Of Pennsylvania |
Treatment of cancer using GFR α-4 chimeric antigen receptor
|
|
TW202140557A
(zh)
|
2014-08-19 |
2021-11-01 |
瑞士商諾華公司 |
使用cd123嵌合抗原受體治療癌症
|
|
MA40608A
(fr)
|
2014-09-09 |
2016-03-17 |
Janssen Biotech Inc |
Polythérapies avec des anticorps anti-cd38
|
|
BR112017004802A2
(pt)
|
2014-09-12 |
2017-12-12 |
Genentech Inc |
anticorpos anti-cll-1 e imunoconjugados
|
|
MX2017003645A
(es)
|
2014-09-17 |
2017-05-30 |
Novartis Ag |
Direccion de celulas citotoxicas con receptores quimericos para inmunoterapia adoptiva.
|
|
MA40764A
(fr)
|
2014-09-26 |
2017-08-01 |
Chugai Pharmaceutical Co Ltd |
Agent thérapeutique induisant une cytotoxicité
|
|
CA2963692A1
(en)
|
2014-10-09 |
2016-04-14 |
Engmab Ag |
Bispecific antibodies against cd3epsilon and ror1
|
|
JP6877339B2
(ja)
|
2014-10-14 |
2021-05-26 |
ノバルティス アーゲー |
Ｐｄ−ｌ１に対する抗体分子およびその使用
|
|
CN107530419B
(zh)
|
2014-10-31 |
2021-05-18 |
昂考梅德药品有限公司 |
治疗疾病的组合疗法
|
|
US11773166B2
(en)
|
2014-11-04 |
2023-10-03 |
Ichnos Sciences SA |
CD3/CD38 T cell retargeting hetero-dimeric immunoglobulins and methods of their production
|
|
AR102522A1
(es)
|
2014-11-06 |
2017-03-08 |
Hoffmann La Roche |
Variantes de región fc con propiedades modificadas de unión a fcrn y proteína a
|
|
RU2714116C2
(ru)
|
2014-11-06 |
2020-02-11 |
Ф. Хоффманн-Ля Рош Аг |
ВАРИАНТЫ Fc-ОБЛАСТИ С МОДИФИЦИРОВАННЫМ СВЯЗЫВАНИЕМ FcRn И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
|
|
LT3789402T
(lt)
|
2014-11-20 |
2022-09-26 |
F. Hoffmann-La Roche Ag |
Kompleksinė terapija, naudojant t ląsteles aktyvinančias bispecifines antigeną surišančias molekules ir pd-1 ašį surišančius antagonistus
|
|
DK3221356T3
(da)
|
2014-11-20 |
2020-11-02 |
Hoffmann La Roche |
T-celleaktiverende, bispecifikke, antigenbindende molekyler mod folr1 og cd3
|
|
EP3023437A1
(en)
|
2014-11-20 |
2016-05-25 |
EngMab AG |
Bispecific antibodies against CD3epsilon and BCMA
|
|
CA2968162A1
(en)
|
2014-11-20 |
2016-05-26 |
F. Hoffmann-La Roche Ag |
Common light chains and methods of use
|
|
US10259887B2
(en)
|
2014-11-26 |
2019-04-16 |
Xencor, Inc. |
Heterodimeric antibodies that bind CD3 and tumor antigens
|
|
IL252467B
(en)
|
2014-11-26 |
2022-06-01 |
Xencor Inc |
Heterodimeric antibodies that bind cd3 and cd38
|
|
TN2017000223A1
(en)
|
2014-11-26 |
2018-10-19 |
Xencor Inc |
Heterodimeric antibodies that bind cd3 and tumor antigens
|
|
JP6721590B2
(ja)
|
2014-12-03 |
2020-07-15 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
多重特異性抗体
|
|
US20180334490A1
(en)
|
2014-12-03 |
2018-11-22 |
Qilong H. Wu |
Methods for b cell preconditioning in car therapy
|
|
CA2969717A1
(en)
|
2014-12-04 |
2016-06-09 |
Janssen Biotech, Inc. |
Anti-cd38 antibodies for treatment of acute myeloid leukemia
|
|
AU2015357053B2
(en)
*
|
2014-12-05 |
2021-10-07 |
Merck Patent Gmbh |
Domain-exchanged antibody
|
|
WO2016097300A1
(en)
|
2014-12-19 |
2016-06-23 |
Genmab A/S |
Rodent bispecific heterodimeric proteins
|
|
US10428155B2
(en)
|
2014-12-22 |
2019-10-01 |
Xencor, Inc. |
Trispecific antibodies
|
|
KR102663073B1
(ko)
|
2015-01-08 |
2024-05-07 |
젠맵 에이/에스 |
Cd3 및 cd20에 대항한 이중특이적 항체
|
|
WO2016130516A1
(en)
|
2015-02-09 |
2016-08-18 |
Research Development Foundation |
Engineered immunoglobulin fc polypeptides displaying improved complement activation
|
|
US10227411B2
(en)
|
2015-03-05 |
2019-03-12 |
Xencor, Inc. |
Modulation of T cells with bispecific antibodies and FC fusions
|
|
JP7082484B2
(ja)
|
2015-04-01 |
2022-06-08 |
中外製薬株式会社 |
ポリペプチド異種多量体の製造方法
|
|
IL254817B2
(en)
|
2015-04-08 |
2023-12-01 |
Novartis Ag |
Cd20 therapies, cd22 therapies, and combination therapies with a cd19 chimeric antigen receptor (car) - expressing cell
|
|
EP3286211A1
(en)
|
2015-04-23 |
2018-02-28 |
Novartis AG |
Treatment of cancer using chimeric antigen receptor and protein kinase a blocker
|
|
WO2016187546A1
(en)
|
2015-05-20 |
2016-11-24 |
Janssen Biotech, Inc. |
Anti-cd38 antibodies for treatment of light chain amyloidosis and other cd38-positive hematological malignancies
|
|
CN104833797B
(zh)
*
|
2015-06-04 |
2017-02-01 |
武汉友芝友生物制药有限公司 |
检测双特异性抗体msbody的elisa方法及应用
|
|
TWI773646B
(zh)
|
2015-06-08 |
2022-08-11 |
美商宏觀基因股份有限公司 |
結合lag-3的分子和其使用方法
|
|
HUE063270T2
(hu)
|
2015-06-16 |
2024-01-28 |
Hoffmann La Roche |
Az FcRH5 elleni humanizált és affinitásérett antitestek és alkalmazási eljárások
|
|
EP3310378B1
(en)
|
2015-06-16 |
2024-01-24 |
F. Hoffmann-La Roche AG |
Anti-cll-1 antibodies and methods of use
|
|
US10668149B2
(en)
|
2015-06-22 |
2020-06-02 |
Janssen Biotech, Inc. |
Combination therapies for heme malignancies with anti-CD38 antibodies and survivin inhibitors
|
|
CN113929779B
(zh)
|
2015-06-24 |
2025-02-25 |
豪夫迈·罗氏有限公司 |
人源化的抗-Tau(pS422)抗体和使用方法
|
|
CN107921120A
(zh)
|
2015-06-24 |
2018-04-17 |
詹森生物科技公司 |
用特异性结合cd38的抗体免疫调节和治疗实体瘤
|
|
WO2017005649A1
(en)
|
2015-07-09 |
2017-01-12 |
Genmab A/S |
Bispecific and multispecific antibodies and method for isolation of such
|
|
EA201890028A1
(ru)
|
2015-07-10 |
2018-08-31 |
Мерус Н.В. |
Антитело, связывающее cd3 человека
|
|
EP3319993B1
(en)
|
2015-07-10 |
2020-01-15 |
Genmab A/S |
Axl-specific antibody-drug conjugates for cancer treatment
|
|
CN114989302B
(zh)
|
2015-07-15 |
2025-08-05 |
根马布股份公司 |
人源化或嵌合cd3抗体
|
|
EP3878465A1
(en)
|
2015-07-29 |
2021-09-15 |
Novartis AG |
Combination therapies comprising antibody molecules to tim-3
|
|
EP3964528A1
(en)
|
2015-07-29 |
2022-03-09 |
Novartis AG |
Combination therapies comprising antibody molecules to lag-3
|
|
WO2017019896A1
(en)
|
2015-07-29 |
2017-02-02 |
Novartis Ag |
Combination therapies comprising antibody molecules to pd-1
|
|
SG10201906059VA
(en)
|
2015-07-30 |
2019-08-27 |
Macrogenics Inc |
Pd-1-binding molecules and methods of use thereof
|
|
MX2018001522A
(es)
|
2015-08-05 |
2018-03-15 |
Janssen Biotech Inc |
Anticuerpos anti-cd154 y metodos de uso de estos.
|
|
JP6967003B2
(ja)
|
2015-09-23 |
2021-11-17 |
メレオ バイオファーマ ５ インコーポレイテッド |
がんの処置のための方法および組成物
|
|
BR112018006360A2
(pt)
|
2015-09-30 |
2018-10-09 |
Janssen Biotech Inc |
anticorpos agonísticos que se ligam especificamente ao cd40 humano e métodos de uso
|
|
AR106188A1
(es)
|
2015-10-01 |
2017-12-20 |
Hoffmann La Roche |
Anticuerpos anti-cd19 humano humanizados y métodos de utilización
|
|
EP3150637A1
(en)
|
2015-10-02 |
2017-04-05 |
F. Hoffmann-La Roche AG |
Multispecific antibodies
|
|
JP2018533930A
(ja)
|
2015-10-02 |
2018-11-22 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
二重特異性ｔ細胞活性化抗原結合分子
|
|
CN107849137B
(zh)
|
2015-10-02 |
2021-11-26 |
豪夫迈·罗氏有限公司 |
双特异性抗ceaxcd3 t细胞活化性抗原结合分子
|
|
WO2017055391A1
(en)
|
2015-10-02 |
2017-04-06 |
F. Hoffmann-La Roche Ag |
Bispecific t cell activating antigen binding molecules binding mesothelin and cd3
|
|
WO2017055395A1
(en)
|
2015-10-02 |
2017-04-06 |
F. Hoffmann-La Roche Ag |
Anti-cd3xrob04 bispecific t cell activating antigen binding molecules
|
|
WO2017055393A1
(en)
|
2015-10-02 |
2017-04-06 |
F. Hoffmann-La Roche Ag |
Anti-cd3xtim-3 bispecific t cell activating antigen binding molecules
|
|
WO2017055392A1
(en)
|
2015-10-02 |
2017-04-06 |
F. Hoffmann-La Roche Ag |
Anti-cd3xcd44v6 bispecific t cell activating antigen binding molecules
|
|
WO2017055399A1
(en)
|
2015-10-02 |
2017-04-06 |
F. Hoffmann-La Roche Ag |
Cellular based fret assay for the determination of simultaneous binding
|
|
MY192202A
(en)
|
2015-10-02 |
2022-08-06 |
Hoffmann La Roche |
Bispecific antibodies specific for pd1 and tim3
|
|
WO2017055385A1
(en)
|
2015-10-02 |
2017-04-06 |
F. Hoffmann-La Roche Ag |
Anti-cd3xgd2 bispecific t cell activating antigen binding molecules
|
|
WO2017055314A1
(en)
|
2015-10-02 |
2017-04-06 |
F. Hoffmann-La Roche Ag |
Bispecific anti-cd19xcd3 t cell activating antigen binding molecules
|
|
KR20180084772A
(ko)
|
2015-10-08 |
2018-07-25 |
마크로제닉스, 인크. |
암 치료를 위한 조합 치료법
|
|
EP4524161A3
(en)
|
2015-10-08 |
2025-06-04 |
Zymeworks BC Inc. |
Antigen-binding polypeptide constructs comprising kappa and lambda light chains and uses thereof
|
|
HRP20210483T1
(hr)
|
2015-10-23 |
2021-07-09 |
Merus N.V. |
Vezujuće molekule koje inhibiraju rast raka
|
|
EP3368568B1
(en)
|
2015-10-29 |
2022-04-06 |
F. Hoffmann-La Roche AG |
Anti-variant fc-region antibodies and methods of use
|
|
AU2016349152A1
(en)
*
|
2015-11-03 |
2018-06-14 |
Merck Patent Gmbh |
Bi-specific antibodies for enhanced tumor selectivity and inhibition and uses thereof
|
|
SMT202100192T1
(it)
|
2015-11-03 |
2021-05-07 |
Janssen Biotech Inc |
Formulazioni sottocutanee di anticorpi anti-cd38 e loro usi.
|
|
LT3370768T
(lt)
|
2015-11-03 |
2022-05-25 |
Janssen Biotech, Inc. |
Antikūnai, specifiškai surišantys pd-1, ir jų panaudojimas
|
|
US11649293B2
(en)
|
2015-11-18 |
2023-05-16 |
Chugai Seiyaku Kabushiki Kaisha |
Method for enhancing humoral immune response
|
|
WO2017086367A1
(ja)
|
2015-11-18 |
2017-05-26 |
中外製薬株式会社 |
免疫抑制機能を有する細胞に対するｔ細胞リダイレクト抗原結合分子を用いた併用療法
|
|
SG11201803956UA
(en)
|
2015-12-01 |
2018-06-28 |
Genmab Bv |
Anti-dr5 antibodies and methods of use thereof
|
|
KR20180085800A
(ko)
|
2015-12-07 |
2018-07-27 |
젠코어 인코포레이티드 |
Cd3 및 psma에 결합하는 이종이합체성 항체
|
|
IL313608A
(en)
|
2015-12-09 |
2024-08-01 |
Hoffmann La Roche |
Antibody against CD20 type II to reduce the formation of antibodies against drugs
|
|
EP3178848A1
(en)
|
2015-12-09 |
2017-06-14 |
F. Hoffmann-La Roche AG |
Type ii anti-cd20 antibody for reducing formation of anti-drug antibodies
|
|
CR20180318A
(es)
|
2015-12-14 |
2018-09-19 |
Macrogenics Inc |
Moléculas biespecíficas que tienen inmunorreactividad con pd-1 y ctla-4, y métodos de uso de las mismas
|
|
EP3389713A2
(en)
|
2015-12-17 |
2018-10-24 |
Novartis AG |
Combination of c-met inhibitor with antibody molecule to pd-1 and uses thereof
|
|
EP4424322A3
(en)
|
2015-12-17 |
2025-04-16 |
Novartis AG |
Antibody molecules to pd-1 and uses thereof
|
|
JP2019502698A
(ja)
|
2015-12-17 |
2019-01-31 |
ヤンセン バイオテツク，インコーポレーテツド |
Ｈｌａ−ｄｒに特異的に結合する抗体及びその使用
|
|
US11413340B2
(en)
|
2015-12-22 |
2022-08-16 |
Novartis Ag |
Mesothelin chimeric antigen receptor (CAR) and antibody against PD-L1 inhibitor for combined use in anticancer therapy
|
|
WO2017115773A1
(ja)
|
2015-12-28 |
2017-07-06 |
中外製薬株式会社 |
Ｆｃ領域含有ポリペプチドの精製を効率化するための方法
|
|
EP3400246B1
(en)
|
2016-01-08 |
2020-10-21 |
H. Hoffnabb-La Roche Ag |
Methods of treating cea-positive cancers using pd-1 axis binding antagonists and anti-cea/anti-cd3 bispecific antibodies
|
|
ES2847155T3
(es)
|
2016-01-21 |
2021-08-02 |
Novartis Ag |
Moléculas multiespecíficas que fijan como objetivo CLL-1
|
|
WO2017142928A1
(en)
|
2016-02-17 |
2017-08-24 |
Macrogenics, Inc. |
Ror1-binding molecules, and methods of use thereof
|
|
AU2017225733A1
(en)
|
2016-03-04 |
2018-09-27 |
Novartis Ag |
Cells expressing multiple chimeric antigen receptor (CAR) molecules and uses therefore
|
|
RU2746754C2
(ru)
|
2016-03-14 |
2021-04-20 |
Чугаи Сейяку Кабусики Кайся |
Индуцирующее повреждение клеток терапевтическое лекарственное средство, предназначенное для противораковой терапии
|
|
CA3017776A1
(en)
|
2016-03-15 |
2017-09-21 |
Generon (Shanghai) Corporation Ltd. |
Multispecific fab fusion proteins and use thereof
|
|
WO2017165464A1
(en)
|
2016-03-21 |
2017-09-28 |
Elstar Therapeutics, Inc. |
Multispecific and multifunctional molecules and uses thereof
|
|
PL3433280T3
(pl)
|
2016-03-22 |
2023-07-31 |
F. Hoffmann-La Roche Ag |
Dwuswoiste cząsteczki limfocytów T aktywowane przez proteazy
|
|
US11549099B2
(en)
|
2016-03-23 |
2023-01-10 |
Novartis Ag |
Cell secreted minibodies and uses thereof
|
|
CR20180484A
(es)
|
2016-04-15 |
2019-03-05 |
Macrogenics Inc |
Moléculas de unón b7-h3 novedosas, conjugados anticuerpos-fármaco de los mismos y métodos de uso de los mismos
|
|
CA3021027A1
(en)
|
2016-04-15 |
2017-10-19 |
Novartis Ag |
Compositions and methods for selective expression of chimeric antigen receptors
|
|
CA3015371A1
(en)
|
2016-04-20 |
2017-10-26 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for making antibodies based on use of an expression-enhancing locus
|
|
SG10202010155YA
(en)
|
2016-04-20 |
2020-11-27 |
Regeneron Pharma |
Compositions and methods for making antibodies based on use of expression-enhancing loci
|
|
AU2017259869A1
(en)
|
2016-05-02 |
2018-09-27 |
F. Hoffmann-La Roche Ag |
The contorsbody - a single chain target binder
|
|
AR108377A1
(es)
|
2016-05-06 |
2018-08-15 |
Medimmune Llc |
Proteínas de unión biespecíficas y sus usos
|
|
EP3252078A1
(en)
|
2016-06-02 |
2017-12-06 |
F. Hoffmann-La Roche AG |
Type ii anti-cd20 antibody and anti-cd20/cd3 bispecific antibody for treatment of cancer
|
|
US20210177896A1
(en)
|
2016-06-02 |
2021-06-17 |
Novartis Ag |
Therapeutic regimens for chimeric antigen receptor (car)- expressing cells
|
|
MA45255A
(fr)
|
2016-06-14 |
2019-04-17 |
Xencor Inc |
Anticorps inhibiteurs de points de contrôle bispécifiques
|
|
JP2019527678A
(ja)
|
2016-06-28 |
2019-10-03 |
ユーエムセー・ユトレヒト・ホールディング・ベー・フェー |
ＣＤ３８に特異的に結合する抗体によるＩｇＥ媒介疾患の治療
|
|
CA3029328A1
(en)
|
2016-06-28 |
2018-01-04 |
Xencor, Inc. |
Heterodimeric antibodies that bind somatostatin receptor 2
|
|
HRP20240603T1
(hr)
|
2016-07-01 |
2024-07-19 |
Resolve Therapeutics, Llc |
Optimizirane fuzije binukleaze i postupci njihove upotrebe
|
|
EP3478717B1
(en)
|
2016-07-04 |
2022-01-05 |
F. Hoffmann-La Roche AG |
Novel antibody format
|
|
EP3484922A1
(en)
|
2016-07-14 |
2019-05-22 |
Genmab A/S |
Multispecific antibodies against cd40 and cd137
|
|
CN110461315B
(zh)
|
2016-07-15 |
2025-05-02 |
诺华股份有限公司 |
使用与激酶抑制剂组合的嵌合抗原受体治疗和预防细胞因子释放综合征
|
|
TW201806619A
(zh)
|
2016-07-28 |
2018-03-01 |
瑞士商諾華公司 |
嵌合抗原受體及pd-1抑制劑之組合療法
|
|
CA3032581A1
(en)
|
2016-08-01 |
2018-02-08 |
Novartis Ag |
Treatment of cancer using a chimeric antigen receptor in combination with an inhibitor of a pro-m2 macrophage molecule
|
|
BR112019002394B1
(pt)
|
2016-08-10 |
2021-12-21 |
Ajou University Industry-Academic Cooperation Foundation |
Proteína heterodimérica fundida com fc e seu uso
|
|
US10669344B2
(en)
|
2016-08-12 |
2020-06-02 |
Janssen Biotech, Inc. |
Engineered antibodies and other Fc-domain containing molecules with enhanced agonism and effector functions
|
|
US20180044430A1
(en)
|
2016-08-12 |
2018-02-15 |
Janssen Biotech, Inc. |
FC Engineered Anti-TNFR Superfamily Member Antibodies Having Enhanced Atonistic Activity and Methods of Using Them
|
|
US10793632B2
(en)
|
2016-08-30 |
2020-10-06 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
|
DK3512882T3
(da)
|
2016-09-14 |
2021-05-31 |
Merck Patent Gmbh |
Anti-c-met-antistoffer og antistoflægemiddelkonjugater deraf til effektiv tumorinhibering
|
|
IL265485B2
(en)
|
2016-09-20 |
2024-07-01 |
Pfizer |
Diagnostic anti-PD-L1 antibody and its use
|
|
EP3519820B1
(en)
|
2016-09-30 |
2020-12-09 |
H. Hoffnabb-La Roche Ag |
Spr-based dual-binding assay for the functional analysis of multispecific molecules
|
|
PL3519437T3
(pl)
|
2016-09-30 |
2022-01-17 |
F. Hoffmann-La Roche Ag |
Przeciwciała dwuswoiste przeciwko p95HER2
|
|
MY200337A
(en)
|
2016-10-07 |
2023-12-20 |
Novartis Ag |
Nucleic acid molecules encoding chimeric antigen receptors comprising a cd20 binding domain
|
|
JP7142630B2
(ja)
|
2016-10-14 |
2022-09-27 |
ゼンコア インコーポレイテッド |
ＩＬ１５／ＩＬ１５Ｒαヘテロ二量体ＦＣ－融合タンパク質
|
|
WO2018083126A1
(en)
|
2016-11-01 |
2018-05-11 |
Genmab B.V. |
Polypeptide variants and uses thereof
|
|
CA3042435A1
(en)
|
2016-11-15 |
2018-05-24 |
Genentech, Inc. |
Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies
|
|
TW201829463A
(zh)
|
2016-11-18 |
2018-08-16 |
瑞士商赫孚孟拉羅股份公司 |
抗hla-g抗體及其用途
|
|
WO2018095932A1
(en)
|
2016-11-22 |
2018-05-31 |
Merck Patent Gmbh |
Monoclonal antibody directed to fgfr1
|
|
KR102630036B1
(ko)
|
2016-12-23 |
2024-01-29 |
마크로제닉스, 인크. |
Adam9-결합 분자, 및 이것의 사용 방법
|
|
EP4043485A1
(en)
|
2017-01-26 |
2022-08-17 |
Novartis AG |
Cd28 compositions and methods for chimeric antigen receptor therapy
|
|
CN110382537B
(zh)
|
2017-02-02 |
2023-07-25 |
默克专利有限公司 |
抗体结构域的优选配对
|
|
CN110945021B
(zh)
|
2017-02-10 |
2025-09-12 |
根马布私人有限公司 |
多肽变体及其用途
|
|
US20200291089A1
(en)
|
2017-02-16 |
2020-09-17 |
Elstar Therapeutics, Inc. |
Multifunctional molecules comprising a trimeric ligand and uses thereof
|
|
EP3586872A4
(en)
|
2017-02-24 |
2020-12-30 |
Chugai Seiyaku Kabushiki Kaisha |
PHARMACEUTICAL COMPOSITION, ANTIGEN BINDING MOLECULES, METHOD OF TREATMENT AND METHOD OF SCREENING
|
|
US11685776B2
(en)
|
2017-03-02 |
2023-06-27 |
Novartis Ag |
Engineered heterodimeric proteins
|
|
IL322509A
(en)
|
2017-03-09 |
2025-10-01 |
Genmab As |
Antibodies against PD-L1
|
|
PE20191360A1
(es)
|
2017-03-10 |
2019-10-01 |
Hoffmann La Roche |
Metodo para producir anticuerpos multiespecificos
|
|
JP7165717B2
(ja)
|
2017-03-15 |
2022-11-04 |
パンディオン・オペレーションズ・インコーポレイテッド |
標的免疫寛容
|
|
US20200270359A1
(en)
|
2017-03-31 |
2020-08-27 |
Genmab Holding B.V. |
Bispecific anti-cd37 antibodies, monoclonal anti-cd37 antibodies and methods of use thereof
|
|
KR20260006707A
(ko)
|
2017-03-31 |
2026-01-13 |
메뤼스 엔.페. |
NRG1 융합 유전자를 가지는 세포를 치료하기 위한 ErbB2 및 ErbB3 결합 이중특이적 항체
|
|
WO2018184964A1
(en)
|
2017-04-03 |
2018-10-11 |
F. Hoffmann-La Roche Ag |
Immunoconjugates of an anti-pd-1 antibody with a mutant il-2 or with il-15
|
|
WO2018184966A1
(en)
|
2017-04-03 |
2018-10-11 |
F. Hoffmann-La Roche Ag |
Antibodies binding to steap-1
|
|
WO2018187227A1
(en)
|
2017-04-03 |
2018-10-11 |
Concologie, Inc. |
Methods for treating cancer using ps-targeting antibodies with immuno-oncology agents
|
|
WO2018184965A1
(en)
|
2017-04-03 |
2018-10-11 |
F. Hoffmann-La Roche Ag |
Immunoconjugates of il-2 with an anti-pd-1 and tim-3 bispecific antibody
|
|
EP3606955B1
(en)
|
2017-04-05 |
2024-11-06 |
F. Hoffmann-La Roche AG |
Bispecific antibodies specifically binding to pd1 and lag3
|
|
AU2018250875A1
(en)
|
2017-04-13 |
2019-10-03 |
F. Hoffmann-La Roche Ag |
An interleukin-2 immunoconjugate, a CD40 agonist, and optionally a PD-1 axis binding antagonist for use in methods of treating cancer
|
|
EP3615068A1
(en)
|
2017-04-28 |
2020-03-04 |
Novartis AG |
Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor
|
|
EP3615055A1
(en)
|
2017-04-28 |
2020-03-04 |
Novartis AG |
Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor
|
|
AU2018271157C1
(en)
|
2017-05-17 |
2021-11-18 |
Merus N.V. |
Combination of an ErbB-2/ErbB-3 bispecific antibody with endocrine therapy for breast cancer
|
|
US10676516B2
(en)
|
2017-05-24 |
2020-06-09 |
Pandion Therapeutics, Inc. |
Targeted immunotolerance
|
|
US20210246227A1
(en)
|
2017-05-31 |
2021-08-12 |
Elstar Therapeutics, Inc. |
Multispecific molecules that bind to myeloproliferative leukemia (mpl) protein and uses thereof
|
|
EP3630829A1
(en)
|
2017-06-02 |
2020-04-08 |
H. Hoffnabb-La Roche Ag |
Type ii anti-cd20 antibody and anti-cd20/cd3 bispecific antibody for treatment of cancer
|
|
JP2020522543A
(ja)
|
2017-06-07 |
2020-07-30 |
ゲンマブ ビー．ブイ． |
変異ＩｇＧ六量体に基づく治療用抗体
|
|
GB201709970D0
(en)
|
2017-06-22 |
2017-08-09 |
Kymab Ltd |
Bispecific antigen-binding molecules
|
|
US11312783B2
(en)
|
2017-06-22 |
2022-04-26 |
Novartis Ag |
Antibody molecules to CD73 and uses thereof
|
|
KR20200022447A
(ko)
|
2017-06-27 |
2020-03-03 |
노파르티스 아게 |
항-tim-3 항체의 투여 요법 및 그의 용도
|
|
AU2018291497A1
(en)
|
2017-06-30 |
2020-01-16 |
Xencor, Inc. |
Targeted heterodimeric Fc fusion proteins containing IL-15/IL-15Ra and antigen binding domains
|
|
AR112603A1
(es)
|
2017-07-10 |
2019-11-20 |
Lilly Co Eli |
Anticuerpos biespecíficos inhibidores de punto de control
|
|
CA3069438A1
(en)
|
2017-07-11 |
2019-01-17 |
Compass Therapeutics Llc |
Agonist antibodies that bind human cd137 and uses thereof
|
|
KR20200031659A
(ko)
|
2017-07-20 |
2020-03-24 |
노파르티스 아게 |
항-lag-3 항체의 투여 요법 및 그의 용도
|
|
CA3071211A1
(en)
|
2017-08-04 |
2019-02-07 |
Genmab A/S |
Binding agents binding to pd-l1 and cd137 and use thereof
|
|
DK3665198T3
(da)
|
2017-08-09 |
2025-04-28 |
Merus Nv |
Antistoffer, der binder egfr og cmet
|
|
WO2019035938A1
(en)
|
2017-08-16 |
2019-02-21 |
Elstar Therapeutics, Inc. |
MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF
|
|
EP3672986A1
(en)
|
2017-08-22 |
2020-07-01 |
Sanabio, LLC |
Soluble interferon receptors and uses thereof
|
|
US20210130396A1
(en)
|
2017-08-30 |
2021-05-06 |
Ares Trading S.A. |
Method for purifying proteins
|
|
SG11202001772SA
(en)
|
2017-09-21 |
2020-04-29 |
Merck Patent Gmbh |
Fusion protein comprising an fgf-18 moiety
|
|
BR112020005742A2
(pt)
|
2017-09-21 |
2020-10-13 |
Umc Utrecht Holding B.V. |
anticorpo anti-gd2 para o tratamento de neuroblastoma
|
|
MX2020003497A
(es)
|
2017-10-20 |
2020-07-22 |
Hoffmann La Roche |
Metodo para generar anticuerpos multiespecificos a partir de anticuerpos monoespecificos.
|
|
KR102831164B1
(ko)
|
2017-10-30 |
2025-07-07 |
에프. 호프만-라 로슈 아게 |
단일특이적 항체로부터 다중특이적 항체의 생체내 생성 방법
|
|
WO2019089753A2
(en)
|
2017-10-31 |
2019-05-09 |
Compass Therapeutics Llc |
Cd137 antibodies and pd-1 antagonists and uses thereof
|
|
CN111246884A
(zh)
|
2017-11-01 |
2020-06-05 |
豪夫迈·罗氏有限公司 |
新颖的含有tnf家族配体三聚体的抗原结合分子
|
|
CA3079129C
(en)
|
2017-11-01 |
2023-02-28 |
F. Hoffmann-La Roche Ag |
Trifab-contorsbody
|
|
MA50505A
(fr)
|
2017-11-01 |
2020-09-09 |
Hoffmann La Roche |
Anticorps 2 + 1 bispécifiques (contorsbodies)
|
|
WO2019086394A1
(en)
|
2017-11-01 |
2019-05-09 |
F. Hoffmann-La Roche Ag |
The compbody - a multivalent target binder
|
|
US11312770B2
(en)
|
2017-11-08 |
2022-04-26 |
Xencor, Inc. |
Bispecific and monospecific antibodies using novel anti-PD-1 sequences
|
|
US10981992B2
(en)
|
2017-11-08 |
2021-04-20 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
|
CA3081602A1
(en)
|
2017-11-16 |
2019-05-23 |
Novartis Ag |
Combination therapies
|
|
US11851497B2
(en)
|
2017-11-20 |
2023-12-26 |
Compass Therapeutics Llc |
CD137 antibodies and tumor antigen-targeting antibodies and uses thereof
|
|
US10174092B1
(en)
|
2017-12-06 |
2019-01-08 |
Pandion Therapeutics, Inc. |
IL-2 muteins
|
|
USRE50550E1
(en)
|
2017-12-06 |
2025-08-26 |
Pandion Operations, Inc. |
IL-2 muteins and uses thereof
|
|
US10946068B2
(en)
|
2017-12-06 |
2021-03-16 |
Pandion Operations, Inc. |
IL-2 muteins and uses thereof
|
|
US11795226B2
(en)
|
2017-12-12 |
2023-10-24 |
Macrogenics, Inc. |
Bispecific CD16-binding molecules and their use in the treatment of disease
|
|
JP7765181B2
(ja)
|
2017-12-19 |
2025-11-06 |
ゼンコア インコーポレイテッド |
改変されたｉｌ－２ ｆｃ融合タンパク質
|
|
CN111527107B
(zh)
|
2017-12-21 |
2024-10-01 |
豪夫迈·罗氏有限公司 |
结合hla-a2/wt1的抗体
|
|
EP3728327A1
(en)
|
2017-12-22 |
2020-10-28 |
F. Hoffmann-La Roche AG |
Depletion of light chain mispaired antibody variants by hydrophobic interaction chromatography
|
|
EP3737692A4
(en)
|
2018-01-09 |
2021-09-29 |
Elstar Therapeutics, Inc. |
CALRETICULIN AND MODIFIED T-LYMPHOCYTES BINDING CONSTRUCTIONS FOR THE TREATMENT OF DISEASES
|
|
WO2019140320A1
(en)
|
2018-01-12 |
2019-07-18 |
Genzyme Corporation |
Methods for the quantitation of polypeptides
|
|
US12398209B2
(en)
|
2018-01-22 |
2025-08-26 |
Janssen Biotech, Inc. |
Methods of treating cancers with antagonistic anti-PD-1 antibodies
|
|
EP3743440A1
(en)
|
2018-01-24 |
2020-12-02 |
Genmab B.V. |
Polypeptide variants and uses thereof
|
|
US20210038659A1
(en)
|
2018-01-31 |
2021-02-11 |
Novartis Ag |
Combination therapy using a chimeric antigen receptor
|
|
CN119733046A
(zh)
|
2018-02-06 |
2025-04-01 |
豪夫迈·罗氏有限公司 |
眼科疾病的治疗
|
|
CR20200391A
(es)
|
2018-02-08 |
2020-10-19 |
Genentech Inc |
Moléculas biespecíficas de unión al antígeno y métodos de uso
|
|
TWI829667B
(zh)
|
2018-02-09 |
2024-01-21 |
瑞士商赫孚孟拉羅股份公司 |
結合gprc5d之抗體
|
|
WO2019160007A1
(ja)
|
2018-02-14 |
2019-08-22 |
中外製薬株式会社 |
抗原結合分子および組合せ
|
|
CN111787949A
(zh)
|
2018-02-15 |
2020-10-16 |
宏观基因有限公司 |
变体cd3-结合结构域及其在用于治疗疾病的组合疗法中的用途
|
|
WO2019175198A2
(en)
|
2018-03-12 |
2019-09-19 |
Genmab A/S |
Antibodies
|
|
WO2019178364A2
(en)
|
2018-03-14 |
2019-09-19 |
Elstar Therapeutics, Inc. |
Multifunctional molecules and uses thereof
|
|
WO2019178362A1
(en)
|
2018-03-14 |
2019-09-19 |
Elstar Therapeutics, Inc. |
Multifunctional molecules that bind to calreticulin and uses thereof
|
|
US10982006B2
(en)
|
2018-04-04 |
2021-04-20 |
Xencor, Inc. |
Heterodimeric antibodies that bind fibroblast activation protein
|
|
US20210147547A1
(en)
|
2018-04-13 |
2021-05-20 |
Novartis Ag |
Dosage Regimens For Anti-Pd-L1 Antibodies And Uses Thereof
|
|
AR114789A1
(es)
|
2018-04-18 |
2020-10-14 |
Hoffmann La Roche |
Anticuerpos anti-hla-g y uso de los mismos
|
|
CA3097741A1
(en)
|
2018-04-18 |
2019-10-24 |
Xencor, Inc. |
Tim-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and tim-3 antigen binding domains
|
|
AR115052A1
(es)
|
2018-04-18 |
2020-11-25 |
Hoffmann La Roche |
Anticuerpos multiespecíficos y utilización de los mismos
|
|
WO2019204646A1
(en)
|
2018-04-18 |
2019-10-24 |
Xencor, Inc. |
Lag-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and lag-3 antigen binding domains
|
|
MA52289A
(fr)
|
2018-04-18 |
2021-02-24 |
Xencor Inc |
Protéines de fusion fc hétérodimères il-15/il-15ra et leurs utilisations
|
|
CN112867734A
(zh)
|
2018-04-18 |
2021-05-28 |
Xencor股份有限公司 |
包含IL-15/IL-15Ra Fc融合蛋白和PD-1抗原结合结构域的靶向PD-1的异源二聚体融合蛋白及其用途
|
|
US20210047405A1
(en)
|
2018-04-27 |
2021-02-18 |
Novartis Ag |
Car t cell therapies with enhanced efficacy
|
|
MA52485A
(fr)
|
2018-05-03 |
2021-03-10 |
Genmab Bv |
Combinaisons de variants d'anticorps et utilisations associées
|
|
JP7395508B2
(ja)
|
2018-05-16 |
2023-12-11 |
ヤンセン バイオテツク，インコーポレーテツド |
癌を治療する方法及びｔ細胞リダイレクト治療薬の有効性を向上させる方法
|
|
HRP20230787T1
(hr)
|
2018-05-18 |
2023-10-27 |
Glycotope Gmbh |
Anti-muc1 antitijelo
|
|
WO2019226658A1
(en)
|
2018-05-21 |
2019-11-28 |
Compass Therapeutics Llc |
Multispecific antigen-binding compositions and methods of use
|
|
JP2021525243A
(ja)
|
2018-05-21 |
2021-09-24 |
コンパス セラピューティクス リミテッド ライアビリティ カンパニー |
Ｎｋ細胞による標的細胞の殺傷を増進するための組成物および方法
|
|
JP2021524255A
(ja)
|
2018-05-24 |
2021-09-13 |
ヤンセン バイオテツク，インコーポレーテツド |
単一特異性及び二重特異性抗体抗−ｔｍｅｆｆ２抗体並びにそれらの使用
|
|
JP7530299B2
(ja)
|
2018-05-24 |
2024-08-07 |
ヤンセン バイオテツク，インコーポレーテツド |
抗ｃｄ３抗体及びその使用
|
|
CA3101272A1
(en)
|
2018-05-24 |
2019-11-28 |
Janssen Biotech, Inc. |
Psma binding agents and uses thereof
|
|
EP3801769A1
(en)
|
2018-05-25 |
2021-04-14 |
Novartis AG |
Combination therapy with chimeric antigen receptor (car) therapies
|
|
WO2019232244A2
(en)
|
2018-05-31 |
2019-12-05 |
Novartis Ag |
Antibody molecules to cd73 and uses thereof
|
|
EP3806962A1
(en)
|
2018-06-13 |
2021-04-21 |
Novartis AG |
Bcma chimeric antigen receptors and uses thereof
|
|
PE20210418A1
(es)
|
2018-06-19 |
2021-03-08 |
Atarga Llc |
Moleculas de anticuerpo de componente de complemento 5 y sus usos
|
|
JP7513530B2
(ja)
|
2018-06-22 |
2024-07-09 |
ジェンマブ ホールディング ビー．ブイ． |
抗ｃｄ３７抗体および抗ｃｄ２０抗体、組成物、ならびにそれらの使用方法
|
|
CN112955465A
(zh)
|
2018-07-03 |
2021-06-11 |
马伦戈治疗公司 |
抗tcr抗体分子及其用途
|
|
AR116109A1
(es)
|
2018-07-10 |
2021-03-31 |
Novartis Ag |
Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos
|
|
MA53122A
(fr)
|
2018-07-13 |
2021-05-19 |
Genmab As |
Variants d'anticorps cd38 et leurs utilisations
|
|
WO2020012038A1
(en)
|
2018-07-13 |
2020-01-16 |
Genmab A/S |
Trogocytosis-mediated therapy using cd38 antibodies
|
|
WO2020021465A1
(en)
|
2018-07-25 |
2020-01-30 |
Advanced Accelerator Applications (Italy) S.R.L. |
Method of treatment of neuroendocrine tumors
|
|
WO2020043849A1
(en)
|
2018-08-29 |
2020-03-05 |
Merck Biodevelopment S.A.S. |
New purification method
|
|
JP7523349B2
(ja)
|
2018-08-29 |
2024-07-26 |
中外製薬株式会社 |
抗体半分子、および抗体半分子のホモ二量体形成を抑制する方法
|
|
GB2576914A
(en)
|
2018-09-06 |
2020-03-11 |
Kymab Ltd |
Antigen-binding molecules comprising unpaired variable domains produced in mammals
|
|
CN112867735B
(zh)
|
2018-09-07 |
2025-05-09 |
埃泰美德(香港)有限公司 |
双特异性抗原结合蛋白及其用途
|
|
EP3856778A1
(en)
|
2018-09-24 |
2021-08-04 |
The Medical College of Wisconsin, Inc. |
System and method for the development of cd30 bispecific antibodies for immunotherapy of cd30+ malignancies
|
|
AU2019355971B2
(en)
|
2018-10-03 |
2025-05-08 |
Xencor, Inc. |
IL-12 heterodimeric Fc-fusion proteins
|
|
MA53812A
(fr)
|
2018-10-04 |
2021-08-11 |
Genmab Holding B V |
Compositions pharmaceutiques comprenant des anticorps anti-cd37 bispécifiques
|
|
US11377477B2
(en)
|
2018-10-12 |
2022-07-05 |
Xencor, Inc. |
PD-1 targeted IL-15/IL-15RALPHA fc fusion proteins and uses in combination therapies thereof
|
|
EP3870598A1
(en)
|
2018-10-23 |
2021-09-01 |
Dragonfly Therapeutics, Inc. |
Heterodimeric fc-fused proteins
|
|
MX2021004774A
(es)
|
2018-10-29 |
2021-08-24 |
Hoffmann La Roche |
Formulacion de anticuerpos.
|
|
AU2019371462A1
(en)
|
2018-11-02 |
2021-05-20 |
University Of Washington |
Orthogonal protein heterodimers
|
|
CN113454111A
(zh)
|
2018-11-06 |
2021-09-28 |
健玛保 |
抗体配制剂
|
|
BR112021008795A2
(pt)
|
2018-11-13 |
2021-08-31 |
Compass Therapeutics Llc |
Construtos de ligação multiespecíficos contra moléculas de ponto de verificação e seus usos
|
|
CA3121699A1
(en)
|
2018-12-05 |
2020-06-11 |
Morphosys Ag |
Multispecific antigen-binding molecules
|
|
TWI874341B
(zh)
|
2018-12-18 |
2025-03-01 |
美商健生生物科技公司 |
產生異二聚體抗體之方法
|
|
GB201820687D0
(en)
|
2018-12-19 |
2019-01-30 |
Kymab Ltd |
Antagonists
|
|
EP3897647B1
(en)
|
2018-12-20 |
2023-11-01 |
Novartis AG |
Combinations of a hdm2-p53 interaction inhibitor and a bcl2 inhibitor and their use for treating cancer
|
|
EP3897853A1
(en)
|
2018-12-20 |
2021-10-27 |
Xencor, Inc. |
Targeted heterodimeric fc fusion proteins containing il-15/il-15ra and nkg2d antigen binding domains
|
|
EP3897637A1
(en)
|
2018-12-20 |
2021-10-27 |
Novartis AG |
Dosing regimen and pharmaceutical combination comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives
|
|
WO2020128049A1
(en)
|
2018-12-21 |
2020-06-25 |
Kymab Limited |
Fixaxfx bispecific antibody with common light chain
|
|
CN113621062B
(zh)
|
2018-12-21 |
2024-07-02 |
豪夫迈·罗氏有限公司 |
与cd3结合的抗体
|
|
JP2022515424A
(ja)
|
2018-12-24 |
2022-02-18 |
サノフイ |
突然変異ｆａｂドメインを有する多重特異性結合タンパク質
|
|
CA3124770A1
(en)
|
2018-12-24 |
2020-07-02 |
Sanofi |
Pseudofab-based multispecific binding proteins
|
|
US20220073630A1
(en)
|
2018-12-28 |
2022-03-10 |
Hoffmann-La Roche, Inc. |
A peptide-mhc-i-antibody fusion protein for therapeutic use in a patient with amplified immune response
|
|
PH12021551475A1
(en)
*
|
2019-01-07 |
2022-05-02 |
Shattuck Labs Inc |
Heterodimeric proteins for modulating gamma delta t cells
|
|
TWI852977B
(zh)
|
2019-01-10 |
2024-08-21 |
美商健生生物科技公司 |
前列腺新抗原及其用途
|
|
JP7303314B2
(ja)
|
2019-01-18 |
2023-07-04 |
ヤンセン バイオテツク，インコーポレーテツド |
Ｇｐｒｃ５ｄキメラ抗原受容体及びそれを発現する細胞
|
|
CN113490528B
(zh)
|
2019-02-15 |
2024-12-03 |
诺华股份有限公司 |
3-(1-氧代-5-(哌啶-4-基)异吲哚啉-2-基)哌啶-2,6-二酮衍生物及其用途
|
|
US10871640B2
(en)
|
2019-02-15 |
2020-12-22 |
Perkinelmer Cellular Technologies Germany Gmbh |
Methods and systems for automated imaging of three-dimensional objects
|
|
ES2982474T3
(es)
|
2019-02-15 |
2024-10-16 |
Novartis Ag |
Derivados de 3-(1-oxoisoindolin-2-il)piperidin-1,6-diona sustituidos y usos de estos
|
|
CN114026122B
(zh)
|
2019-02-21 |
2024-12-31 |
马伦戈治疗公司 |
结合t细胞相关癌细胞的多功能分子及其用途
|
|
WO2020172605A1
(en)
|
2019-02-21 |
2020-08-27 |
Elstar Therapeutics, Inc. |
Antibody molecules that bind to nkp30 and uses thereof
|
|
CA3131014A1
(en)
|
2019-02-21 |
2020-08-27 |
Andreas Loew |
Anti-tcr antibody molecules and uses thereof
|
|
CA3130628A1
(en)
|
2019-02-21 |
2020-08-27 |
Marengo Therapeutics, Inc. |
Multifunctional molecules that bind to t cells and uses thereof to treat autoimmune disorders
|
|
CN114127113A
(zh)
|
2019-02-21 |
2022-03-01 |
马伦戈治疗公司 |
与钙网蛋白结合的多功能分子及其用途
|
|
WO2020172553A1
(en)
|
2019-02-22 |
2020-08-27 |
Novartis Ag |
Combination therapies of egfrviii chimeric antigen receptors and pd-1 inhibitors
|
|
PH12021552030A1
(en)
|
2019-02-26 |
2022-08-15 |
Janssen Biotech Inc |
Combination therapies and patient stratification with bispecific anti-egfr/c-met antibodies
|
|
BR112021016955A2
(pt)
|
2019-03-01 |
2021-11-23 |
Xencor Inc |
Composição, composição de ácido nucleico, composição de vetor de expressão, vetor de expressão, célula hospedeira, métodos de produção de um domínio de ligação de membro de família 3 de pirofosfatase/fosfodiesterase de ectonucleotídeo e de tratamento de um câncer, anticorpo anti-enpp3, e, anticorpo heterodimérico
|
|
EP3947441A1
(en)
|
2019-03-27 |
2022-02-09 |
UMC Utrecht Holding B.V. |
Engineered iga antibodies and methods of use
|
|
WO2020200941A1
(en)
|
2019-03-29 |
2020-10-08 |
F. Hoffmann-La Roche Ag |
Spr-based binding assay for the functional analysis of multivalent molecules
|
|
EP3946593A1
(en)
|
2019-03-29 |
2022-02-09 |
Atarga, LLC |
Anti fgf23 antibody
|
|
CN113677701B
(zh)
|
2019-03-29 |
2025-02-07 |
豪夫迈·罗氏有限公司 |
产生亲合结合多特异性抗体的方法
|
|
EP3956022A1
(en)
|
2019-04-19 |
2022-02-23 |
Janssen Biotech, Inc. |
Methods of treating prostate cancer with an anti- psma/cd3 antibody
|
|
BR112021020859A2
(pt)
|
2019-04-25 |
2022-01-04 |
Hoffmann La Roche |
Conjuntos de polipeptídeos, método para gerar um polipeptídeo, polipeptídeo heterodimérico, primeiro polipeptídeo precursor heterodimérico e segundo polipeptídeo precursor heterodimérico
|
|
MX2021012931A
(es)
|
2019-04-25 |
2021-11-17 |
Hoffmann La Roche |
Polipeptidos multiespecificos activables y terapeuticos con semivida extendida.
|
|
MX2021012871A
(es)
|
2019-04-25 |
2021-11-17 |
Hoffmann La Roche |
Generacion de polipeptidos derivados de anticuerpos mediante intercambio de cadenas polipeptidicas.
|
|
KR20220017892A
(ko)
|
2019-05-08 |
2022-02-14 |
얀센 바이오테크 인코포레이티드 |
T세포 매개 면역의 조절을 위한 물질 및 방법
|
|
WO2020225456A1
(en)
|
2019-05-09 |
2020-11-12 |
Genmab B.V. |
Dosage regimens for a combination of anti-dr5 antibodies for use in treating cancer
|
|
EP3969907B1
(en)
|
2019-05-13 |
2025-09-24 |
F. Hoffmann-La Roche AG |
Interference-suppressed pharmacokinetic immunoassay
|
|
US11879013B2
(en)
|
2019-05-14 |
2024-01-23 |
Janssen Biotech, Inc. |
Combination therapies with bispecific anti-EGFR/c-Met antibodies and third generation EGFR tyrosine kinase inhibitors
|
|
CN114679909A
(zh)
|
2019-05-20 |
2022-06-28 |
潘迪恩运营公司 |
MAdCAM靶向的免疫耐受
|
|
CN113874390A
(zh)
*
|
2019-05-24 |
2021-12-31 |
普罗维瓦疗法香港有限公司 |
Il-2组合物及其使用方法
|
|
CN118547004A
(zh)
|
2019-06-19 |
2024-08-27 |
豪夫迈·罗氏有限公司 |
通过使用Cre mRNA进行的靶向整合来产生蛋白质表达细胞的方法
|
|
CN117821393A
(zh)
|
2019-06-26 |
2024-04-05 |
豪夫迈·罗氏有限公司 |
具有sirt-1基因敲除的哺乳动物细胞系
|
|
WO2021001289A1
(en)
|
2019-07-02 |
2021-01-07 |
F. Hoffmann-La Roche Ag |
Immunoconjugates comprising a mutant interleukin-2 and an anti-cd8 antibody
|
|
AU2020309958A1
(en)
|
2019-07-10 |
2021-12-23 |
Chugai Seiyaku Kabushiki Kaisha |
Claudin-6 binding molecules and uses thereof
|
|
AR119393A1
(es)
|
2019-07-15 |
2021-12-15 |
Hoffmann La Roche |
Anticuerpos que se unen a nkg2d
|
|
JP2022541332A
(ja)
|
2019-07-26 |
2022-09-22 |
ヤンセン バイオテツク，インコーポレーテツド |
カリクレイン関連ペプチダーゼ２抗原結合ドメインを含むタンパク質及びその使用
|
|
EP4004045A1
(en)
|
2019-07-31 |
2022-06-01 |
F. Hoffmann-La Roche AG |
Antibodies binding to gprc5d
|
|
JP2022543553A
(ja)
|
2019-07-31 |
2022-10-13 |
エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト |
Ｇｐｒｃ５ｄに結合する抗体
|
|
MX2022001799A
(es)
|
2019-08-15 |
2022-03-11 |
Janssen Biotech Inc |
Materiales y metodos para fragmentos variables de cadena unica mejorados.
|
|
TW202128757A
(zh)
|
2019-10-11 |
2021-08-01 |
美商建南德克公司 |
具有改善之特性的 PD-1 標靶 IL-15/IL-15Rα FC 融合蛋白
|
|
IL292347A
(en)
|
2019-10-21 |
2022-06-01 |
Novartis Ag |
Combination treatments with ventoclax and tim-3 inhibitors
|
|
BR112022007179A2
(pt)
|
2019-10-21 |
2022-08-23 |
Novartis Ag |
Inibidores de tim-3 e usos dos mesmos
|
|
US20220411529A1
(en)
|
2019-11-06 |
2022-12-29 |
Genmab B.V. |
Antibody variant combinations and uses thereof
|
|
EP4061837A1
(en)
|
2019-11-18 |
2022-09-28 |
Janssen Biotech, Inc. |
Anti-cd79 chimeric antigen receptors, car-t cells, and uses thereof
|
|
CA3163104A1
(en)
|
2019-11-26 |
2021-06-03 |
Novartis Ag |
Chimeric antigen receptors and uses thereof
|
|
EP4072584B1
(en)
|
2019-12-13 |
2026-01-28 |
Genentech, Inc. |
Anti-ly6g6d antibodies and methods of use
|
|
US11739142B2
(en)
|
2019-12-18 |
2023-08-29 |
Hoffmann-La Roche Inc. |
Bispecific anti-CCL2 antibodies
|
|
CR20220256A
(es)
|
2019-12-18 |
2022-08-31 |
Hoffmann La Roche |
Anticuerpos que se unen a hla-a2/mage-a4
|
|
IL293889A
(en)
|
2019-12-20 |
2022-08-01 |
Novartis Ag |
Uses of anti-tgf-beta antibodies and checkpoint inhibitors for the treatment of proliferative diseases
|
|
US11913945B2
(en)
|
2020-01-02 |
2024-02-27 |
Hoffmann-La Roche Inc. |
Method for determining the amount of a therapeutic antibody in the brain
|
|
EP4084821A4
(en)
|
2020-01-03 |
2024-04-24 |
Marengo Therapeutics, Inc. |
Multifunctional molecules that bind to cd33 and uses thereof
|
|
EP4084823A4
(en)
|
2020-01-03 |
2024-05-15 |
Marengo Therapeutics, Inc. |
ANTI-TCR ANTIBODY MOLECULES AND THEIR USES
|
|
BR112022013553A2
(pt)
|
2020-01-16 |
2022-09-06 |
Genmab As |
Composição farmacêutica, anticorpo, e, método para tratar uma doença
|
|
WO2021144657A1
(en)
|
2020-01-17 |
2021-07-22 |
Novartis Ag |
Combination comprising a tim-3 inhibitor and a hypomethylating agent for use in treating myelodysplastic syndrome or chronic myelomonocytic leukemia
|
|
WO2021146636A1
(en)
|
2020-01-17 |
2021-07-22 |
Becton, Dickinson And Company |
Methods and compositions for single cell secretomics
|
|
IL295129A
(en)
|
2020-01-30 |
2022-09-01 |
Umoja Biopharma Inc |
Bispecific transduction enhancer
|
|
WO2021155916A1
(en)
|
2020-02-04 |
2021-08-12 |
BioNTech SE |
Treatment involving antigen vaccination and binding agents binding to pd-l1 and cd137
|
|
JOP20220184A1
(ar)
|
2020-02-12 |
2023-01-30 |
Janssen Biotech Inc |
علاج مصابي السرطان ممن لديهم طفرات تخطي c-Met إكسون14
|
|
TW202144388A
(zh)
|
2020-02-14 |
2021-12-01 |
美商健生生物科技公司 |
在卵巢癌中表現之新抗原及其用途
|
|
TW202144389A
(zh)
|
2020-02-14 |
2021-12-01 |
美商健生生物科技公司 |
在多發性骨髓瘤中表現之新抗原及其用途
|
|
US11981715B2
(en)
|
2020-02-21 |
2024-05-14 |
Pandion Operations, Inc. |
Tissue targeted immunotolerance with a CD39 effector
|
|
MX2022010685A
(es)
|
2020-02-27 |
2022-09-23 |
Novartis Ag |
Metodos de produccion de celulas que expresan receptores de antigeno quimericos.
|
|
PH12022552370A1
(en)
|
2020-03-13 |
2023-12-18 |
Janssen Biotech Inc |
Materials and methods for binding siglec-3/cd33
|
|
AU2021236906A1
(en)
|
2020-03-18 |
2022-08-18 |
Genmab A/S |
Antibodies binding to B7H4
|
|
WO2021190980A1
(en)
|
2020-03-22 |
2021-09-30 |
Quadrucept Bio Limited |
Multimers for viral strain evolution
|
|
CA3173162A1
(en)
|
2020-03-25 |
2021-09-30 |
Eli Lilly And Company |
Multispecific binding proteins and methods of developing the same
|
|
JP2023519699A
(ja)
*
|
2020-03-30 |
2023-05-12 |
サノフイ |
スプリットｃｈ２ドメイン
|
|
AU2021257848A1
(en)
|
2020-04-15 |
2022-12-01 |
Voyager Therapeutics, Inc. |
Tau binding compounds
|
|
MX2022012541A
(es)
|
2020-04-15 |
2022-11-07 |
Hoffmann La Roche |
Inmunoconjugados.
|
|
KR20230028242A
(ko)
|
2020-04-24 |
2023-02-28 |
마렝고 테라퓨틱스, 인크. |
T 세포 관련 암 세포에 결합하는 다중기능성 분자 및 그것의 용도
|
|
US20230172923A1
(en)
|
2020-04-30 |
2023-06-08 |
Bristol-Myers Squibb Company |
Methods of treating cytokine-related adverse events
|
|
US12435154B2
(en)
|
2020-05-08 |
2025-10-07 |
Genmab A/S |
Bispecific antibodies against CD3 and CD20
|
|
CN115551540A
(zh)
|
2020-05-11 |
2022-12-30 |
豪夫迈·罗氏有限公司 |
使用经修饰的pbmc和免疫缀合物的组合疗法
|
|
US11919956B2
(en)
|
2020-05-14 |
2024-03-05 |
Xencor, Inc. |
Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3
|
|
US12460001B2
(en)
|
2020-05-27 |
2025-11-04 |
Janssen Biotech, Inc. |
Proteins comprising CD3 antigen binding domains and uses thereof
|
|
CA3185458A1
(en)
|
2020-06-03 |
2021-12-09 |
Merck Patent Gmbh |
Bispecific antibody-drug conjugates targeting egfr and muc1 and uses thereof
|
|
PH12022500027A1
(en)
|
2020-06-19 |
2024-03-25 |
Hoffmann La Roche |
Antibodies binding to cd3
|
|
CA3185513A1
(en)
|
2020-06-19 |
2021-12-23 |
F. Hoffmann-La Roche Ag |
Antibodies binding to cd3 and folr1
|
|
WO2021255146A1
(en)
|
2020-06-19 |
2021-12-23 |
F. Hoffmann-La Roche Ag |
Antibodies binding to cd3 and cea
|
|
AR122657A1
(es)
|
2020-06-19 |
2022-09-28 |
Hoffmann La Roche |
Moléculas de unión al dominio fc de activación inmunitaria
|
|
IL298402A
(en)
|
2020-06-19 |
2023-01-01 |
Hoffmann La Roche |
Antibodies that bind to CD3 and CD19
|
|
WO2021260528A1
(en)
|
2020-06-23 |
2021-12-30 |
Novartis Ag |
Dosing regimen comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives
|
|
EP4175664A2
(en)
|
2020-07-06 |
2023-05-10 |
Janssen Biotech, Inc. |
Prostate neoantigens and their uses
|
|
MX2023000547A
(es)
|
2020-07-16 |
2023-02-13 |
Novartis Ag |
Anticuerpos anti-betacelulina, fragmentos de los mismos, y moleculas de union multiespecificas.
|
|
US20230293680A1
(en)
|
2020-07-23 |
2023-09-21 |
Genmab B.V. |
A composition of anti-dr5 antibodies and an immunomodulatory imide drug for use in treating multiple myeloma
|
|
WO2022026592A2
(en)
|
2020-07-28 |
2022-02-03 |
Celltas Bio, Inc. |
Antibody molecules to coronavirus and uses thereof
|
|
UY39345A
(es)
|
2020-07-29 |
2022-01-31 |
Janssen Biotech Inc |
Proteínas que comprenden dominios de unión al antígeno hla-g y sus usos
|
|
WO2022029573A1
(en)
|
2020-08-03 |
2022-02-10 |
Novartis Ag |
Heteroaryl substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
|
|
CN116194477A
(zh)
|
2020-08-06 |
2023-05-30 |
生物技术欧洲股份公司 |
冠状病毒s蛋白的结合剂
|
|
KR20230166150A
(ko)
|
2020-08-19 |
2023-12-06 |
젠코어 인코포레이티드 |
항-cd28 조성물
|
|
CA3192922A1
(en)
|
2020-08-25 |
2022-03-03 |
Janssen Biotech, Inc. |
Treatment of non-small cell lung cancer with egfr mutations
|
|
CA3190766A1
(en)
|
2020-08-26 |
2022-03-03 |
Marengo Therapeutics, Inc. |
Antibody molecules that bind to nkp30 and uses thereof
|
|
WO2022047046A1
(en)
|
2020-08-26 |
2022-03-03 |
Marengo Therapeutics, Inc. |
Methods of detecting trbc1 or trbc2
|
|
CN116249718A
(zh)
|
2020-08-26 |
2023-06-09 |
马伦戈治疗公司 |
结合至钙网蛋白的多功能性分子及其用途
|
|
EP4204020A1
(en)
|
2020-08-31 |
2023-07-05 |
Advanced Accelerator Applications International S.A. |
Method of treating psma-expressing cancers
|
|
EP4204021A1
(en)
|
2020-08-31 |
2023-07-05 |
Advanced Accelerator Applications International S.A. |
Method of treating psma-expressing cancers
|
|
US20230310599A1
(en)
|
2020-09-02 |
2023-10-05 |
Genmab A/S |
Antibody therapy
|
|
US20240034812A1
(en)
|
2020-09-10 |
2024-02-01 |
Genmab A/S |
Bispecific antibody against cd3 and cd20 in combination therapy for treating diffuse large b-cell lymphoma
|
|
CN116437956A
(zh)
|
2020-09-10 |
2023-07-14 |
健玛保 |
用于治疗慢性淋巴细胞白血病的针对cd3和cd20的双特异性抗体
|
|
US20220089690A1
(en)
|
2020-09-14 |
2022-03-24 |
Sutro Biopharma, Inc. |
Method for large scale production of antibodies using a cell-free protein synthesis system
|
|
CN116391037A
(zh)
|
2020-09-24 |
2023-07-04 |
豪夫迈·罗氏有限公司 |
具有基因敲除的哺乳动物细胞系
|
|
CA3193914A1
(en)
|
2020-10-02 |
2022-04-07 |
Louise KOOPMAN |
Antibodies capable of binding to ror2 and bispecific antibodies binding to ror2 and cd3
|
|
US11926667B2
(en)
|
2020-10-13 |
2024-03-12 |
Janssen Biotech, Inc. |
Bioengineered T cell mediated immunity, materials and other methods for modulating cluster of differentiation IV and/or VIII
|
|
US20240025992A1
(en)
|
2020-10-22 |
2024-01-25 |
Janssen Biotech, Inc. |
Proteins comprising delta-like ligand 3 (dll3) antigen binding domains and their uses
|
|
WO2022087458A1
(en)
|
2020-10-23 |
2022-04-28 |
Asher Biotherapeutics, Inc. |
Fusions with cd8 antigen binding molecules for modulating immune cell function
|
|
EP4237003A4
(en)
|
2020-10-28 |
2025-07-09 |
Janssen Biotech Inc |
COMPOSITIONS AND METHODS FOR MODULATING GAMMA DELTA CHAIN-MEDIATED IMMUNITY
|
|
JP7716473B2
(ja)
|
2020-11-04 |
2025-07-31 |
ジェネンテック， インコーポレイテッド |
抗ｃｄ２０／抗ｃｄ３二重特異性抗体の皮下投薬
|
|
US12516118B2
(en)
|
2020-11-04 |
2026-01-06 |
Genentech, Inc. |
Dosing for treatment with anti-CD20/anti-CD3 bispecific antibodies and anti-CD79b antibody drug conjugates
|
|
CA3196539A1
(en)
|
2020-11-04 |
2022-05-12 |
Chi-Chung Li |
Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies
|
|
WO2022097065A2
(en)
|
2020-11-06 |
2022-05-12 |
Novartis Ag |
ANTIBODY Fc VARIANTS
|
|
KR20230107305A
(ko)
|
2020-11-10 |
2023-07-14 |
상하이 치루 파마슈티컬 리서치 앤 디벨롭먼트 센터 리미티드 |
클라우딘 18a2 및 cd3에 대한 이중특이성 항체 및 이중특이성 항체의 용도
|
|
JP2023549504A
(ja)
|
2020-11-13 |
2023-11-27 |
ノバルティス アーゲー |
キメラ抗原受容体（ｃａｒ）発現細胞との組合せ療法
|
|
KR20230120665A
(ko)
|
2020-12-17 |
2023-08-17 |
에프. 호프만-라 로슈 아게 |
항-hla-g 항체 및 이의 용도
|
|
WO2022128716A1
(en)
|
2020-12-17 |
2022-06-23 |
Merck Patent Gmbh |
Pharmaceutical composition comprising a bispecific anti-muc1/egfr antibody-drug conjugate
|
|
WO2022129313A1
(en)
|
2020-12-18 |
2022-06-23 |
F. Hoffmann-La Roche Ag |
Precursor proteins and kit for targeted therapy
|
|
WO2022136140A1
(en)
|
2020-12-22 |
2022-06-30 |
F. Hoffmann-La Roche Ag |
Oligonucleotides targeting xbp1
|
|
MX2023007846A
(es)
|
2021-01-06 |
2023-07-07 |
Hoffmann La Roche |
Tratamiento conjunto que usa un anticuerpo biespecifico contra pd1-lag3 y un anticuerpo biespecifico de linfocitos t cd20.
|
|
WO2022148853A1
(en)
|
2021-01-11 |
2022-07-14 |
F. Hoffmann-La Roche Ag |
Immunoconjugates
|
|
KR20230137393A
(ko)
|
2021-01-28 |
2023-10-04 |
얀센 바이오테크 인코포레이티드 |
Psma 결합 단백질 및 이의 용도
|
|
US20240141060A1
(en)
|
2021-01-29 |
2024-05-02 |
Novartis Ag |
Dosage regimes for anti-cd73 and anti-entpd2 antibodies and uses thereof
|
|
US11639396B2
(en)
|
2021-02-16 |
2023-05-02 |
Janssen Biotech, Inc. |
Antibody binding to a linker peptide
|
|
JP2024512240A
(ja)
|
2021-02-18 |
2024-03-19 |
エフ． ホフマン－ラ ロシュ アーゲー |
複雑な多段階の抗体相互作用を解明するための方法
|
|
WO2022184659A1
(en)
|
2021-03-01 |
2022-09-09 |
Quadrucept Bio Limited |
Antibody domains & multimers
|
|
US11739144B2
(en)
|
2021-03-09 |
2023-08-29 |
Xencor, Inc. |
Heterodimeric antibodies that bind CD3 and CLDN6
|
|
JP2024509920A
(ja)
|
2021-03-09 |
2024-03-05 |
ヤンセン バイオテツク，インコーポレーテツド |
Ｅｇｆｒ活性化変異を欠くがんの治療
|
|
KR20230154311A
(ko)
|
2021-03-10 |
2023-11-07 |
젠코어 인코포레이티드 |
Cd3 및 gpc3에 결합하는 이종이량체 항체
|
|
CN116964085A
(zh)
|
2021-03-12 |
2023-10-27 |
根马布股份公司 |
非激活抗体变体
|
|
JP2024512035A
(ja)
|
2021-03-24 |
2024-03-18 |
ヤンセン バイオテツク，インコーポレーテツド |
Ｃｄ２２及びｃｄ７９ｂを標的とする抗体
|
|
CN117377694A
(zh)
|
2021-03-24 |
2024-01-09 |
詹森生物科技公司 |
包含cd3抗原结合结构域的蛋白质及其用途
|
|
WO2022206872A1
(zh)
|
2021-03-31 |
2022-10-06 |
江苏恒瑞医药股份有限公司 |
截短的taci多肽及其融合蛋白和用途
|
|
TW202304979A
(zh)
|
2021-04-07 |
2023-02-01 |
瑞士商諾華公司 |
抗ＴＧＦβ抗體及其他治療劑用於治療增殖性疾病之用途
|
|
WO2022216993A2
(en)
|
2021-04-08 |
2022-10-13 |
Marengo Therapeutics, Inc. |
Multifuntional molecules binding to tcr and uses thereof
|
|
CA3217520A1
(en)
|
2021-04-22 |
2022-10-27 |
Guangdong Fapon Biopharma Inc. |
Bispecific multifunctional fusion polypeptide
|
|
CA3213632A1
(en)
|
2021-04-30 |
2022-11-03 |
F. Hoffmann-La Roche Ag |
Dosing for combination treatment with anti-cd20/anti-cd3 bispecific antibody and anti-cd79b antibody drug conjugate
|
|
EP4329800A1
(en)
|
2021-04-30 |
2024-03-06 |
F. Hoffmann-La Roche AG |
Dosing for treatment with anti-cd20/anti-cd3 bispecific antibody
|
|
BR112023021089A2
(pt)
|
2021-05-07 |
2023-12-12 |
Genmab As |
Composição farmacêutica, método para tratar uma doença, método para tratar câncer em um indivíduo, uso da composição farmacêutica, forma de dosagem unitária, kit de partes, e, método para preparar uma composição farmacêutica
|
|
CA3218542A1
(en)
|
2021-05-12 |
2022-11-17 |
Hua Ying |
Antigen binding molecule specifically binding to rankl and ngf, and medical use thereof
|
|
BR112023023775A2
(pt)
|
2021-05-14 |
2024-02-20 |
Genentech Inc |
Métodos para tratar um indivíduo com um distúrbio proliferativo de células positivas para cd20 e para tratar uma população de indivíduos com um distúrbio proliferativo de células positivas para cd20
|
|
WO2022237882A1
(zh)
|
2021-05-14 |
2022-11-17 |
江苏恒瑞医药股份有限公司 |
一种抗原结合分子
|
|
AR125874A1
(es)
|
2021-05-18 |
2023-08-23 |
Novartis Ag |
Terapias de combinación
|
|
TW202309094A
(zh)
|
2021-05-18 |
2023-03-01 |
美商健生生物科技公司 |
用於識別癌症患者以進行組合治療之方法
|
|
MX2023013723A
(es)
|
2021-05-19 |
2024-02-13 |
Asher Biotherapeutics Inc |
Polipeptidos de il-21 y construcciones dirigidas.
|
|
AU2022295067A1
(en)
|
2021-06-18 |
2023-12-21 |
F. Hoffmann-La Roche Ag |
Bispecific anti-ccl2 antibodies
|
|
WO2022268740A1
(en)
|
2021-06-21 |
2022-12-29 |
Genmab A/S |
Combination dosage regime of cd137 and pd-l1 binding agents
|
|
TW202309078A
(zh)
|
2021-07-02 |
2023-03-01 |
美商建南德克公司 |
治療癌症之方法及組成物
|
|
MX2024000501A
(es)
|
2021-07-14 |
2024-01-31 |
Jiangsu Hengrui Pharmaceuticals Co Ltd |
Molecula de union a antigeno que se une especificamente a hgfr y egfr, y su uso farmaceutico.
|
|
EP4373859A1
(en)
|
2021-07-22 |
2024-05-29 |
F. Hoffmann-La Roche AG |
Heterodimeric fc domain antibodies
|
|
EP4377347A1
(en)
|
2021-07-27 |
2024-06-05 |
MorphoSys AG |
Combinations of antigen binding molecules
|
|
EP4377351A1
(en)
|
2021-07-28 |
2024-06-05 |
F. Hoffmann-La Roche AG |
Methods and compositions for treating cancer
|
|
AU2022338208A1
(en)
|
2021-09-06 |
2024-03-21 |
Genmab A/S |
Antibodies capable of binding to cd27, variants thereof and uses thereof
|
|
AU2022344595A1
(en)
|
2021-09-13 |
2024-05-02 |
Janssen Biotech, Inc |
CD33 X Vδ2 MULTISPECIFIC ANTIBODIES FOR THE TREATMENT OF CANCER
|
|
US20250223376A1
(en)
|
2021-09-20 |
2025-07-10 |
Voyager Therapeutics, Inc. |
Compositions and methods for the treatment of her2 positive cancer
|
|
US20240270874A1
(en)
|
2021-09-23 |
2024-08-15 |
Jiangsu Hengrui Pharmaceuticals Co., Ltd. |
Anti-klb antibodies and uses
|
|
EP4405392A1
(en)
|
2021-09-24 |
2024-07-31 |
Janssen Biotech, Inc. |
Proteins comprising cd20 binding domains, and uses thereof
|
|
CN117916273A
(zh)
|
2021-09-30 |
2024-04-19 |
江苏恒瑞医药股份有限公司 |
抗il23抗体融合蛋白及用途
|
|
CN118414353A
(zh)
|
2021-10-08 |
2024-07-30 |
根马布股份公司 |
与cd30和cd3结合的抗体
|
|
WO2023062048A1
(en)
|
2021-10-14 |
2023-04-20 |
F. Hoffmann-La Roche Ag |
Alternative pd1-il7v immunoconjugates for the treatment of cancer
|
|
CN118215674A
(zh)
|
2021-10-14 |
2024-06-18 |
豪夫迈·罗氏有限公司 |
新颖白细胞介素-7免疫缀合物
|
|
EP4426437A4
(en)
|
2021-11-03 |
2025-09-17 |
Janssen Biotech Inc |
METHODS FOR TREATING CANCER AND ENHANCING THE EFFICACY OF BISPECIFIC BCMAXCD3 ANTIBODIES
|
|
IL312692A
(en)
|
2021-11-16 |
2024-07-01 |
Genentech Inc |
Methods and compositions for the treatment of systemic lupus erythematosus (SLE) with musontuzumab
|
|
WO2023092004A1
(en)
|
2021-11-17 |
2023-05-25 |
Voyager Therapeutics, Inc. |
Compositions and methods for the treatment of tau-related disorders
|
|
CA3239224A1
(en)
|
2021-11-22 |
2023-05-25 |
Janssen Biotech, Inc. |
Compositions comprising enhanced multispecific binding agents for an immune response
|
|
EP4437344A1
(en)
|
2021-11-25 |
2024-10-02 |
F. Hoffmann-La Roche AG |
Quantification of low amounts of antibody sideproducts
|
|
US20230183360A1
(en)
|
2021-12-09 |
2023-06-15 |
Janssen Biotech, Inc. |
Use of Amivantamab to Treat Colorectal Cancer
|
|
AR127887A1
(es)
|
2021-12-10 |
2024-03-06 |
Hoffmann La Roche |
Anticuerpos que se unen a cd3 y plap
|
|
JP2025505611A
(ja)
|
2022-02-07 |
2025-02-28 |
江蘇恒瑞医薬股▲ふん▼有限公司 |
Ｐｓｍａとｃｄ３に特異的に結合する抗原結合分子及びその医薬的使用
|
|
TW202342057A
(zh)
|
2022-02-07 |
2023-11-01 |
美商健生生物科技公司 |
用於減少用ｅｇｆｒ／ｍｅｔ雙特異性抗體治療之患者的輸注相關反應之方法
|
|
WO2023150778A1
(en)
|
2022-02-07 |
2023-08-10 |
Visterra, Inc. |
Anti-idiotype antibody molecules and uses thereof
|
|
WO2023151661A1
(zh)
|
2022-02-11 |
2023-08-17 |
江苏恒瑞医药股份有限公司 |
免疫缀合物及其用途
|
|
MX2024011128A
(es)
|
2022-03-14 |
2024-09-18 |
Jiangsu Hengrui Pharmaceuticals Co Ltd |
Molecula de union a antigeno que se une especificamente a gprc5d y cd3 y su uso medico.
|
|
WO2023174521A1
(en)
|
2022-03-15 |
2023-09-21 |
Genmab A/S |
Binding agents binding to epcam and cd137
|
|
EP4493585A1
(en)
|
2022-03-17 |
2025-01-22 |
Astrazeneca AB |
Methods for purifying bispecific antibodies
|
|
US20230414750A1
(en)
|
2022-03-23 |
2023-12-28 |
Hoffmann-La Roche Inc. |
Combination treatment of an anti-cd20/anti-cd3 bispecific antibody and chemotherapy
|
|
CA3245704A1
(en)
|
2022-03-29 |
2023-10-05 |
Ngm Biopharmaceuticals, Inc. |
ILT3 AND CD3 LINKING AGENTS AND THEIR METHODS OF USE
|
|
CN119013300A
(zh)
|
2022-04-13 |
2024-11-22 |
豪夫迈·罗氏有限公司 |
抗cd20/抗cd3双特异性抗体的药物组合物和使用方法
|
|
WO2023202967A1
(en)
|
2022-04-19 |
2023-10-26 |
F. Hoffmann-La Roche Ag |
Improved production cells
|
|
CA3255838A1
(en)
|
2022-04-26 |
2023-11-02 |
Novartis Ag |
MULTISPECIFIC ANTIBODIES TARGETTING IL-13 AND IL-18
|
|
AU2023269545A1
(en)
|
2022-05-12 |
2024-11-14 |
BioNTech SE |
Binding agents capable of binding to cd27 in combination therapy
|
|
WO2023218051A1
(en)
|
2022-05-12 |
2023-11-16 |
Genmab A/S |
Binding agents capable of binding to cd27 in combination therapy
|
|
US20250295809A1
(en)
|
2022-05-13 |
2025-09-25 |
Voyager Therapeutics, Inc. |
Compositions and methods for the treatment of her2 positive cancer
|
|
JP2025517572A
(ja)
|
2022-06-03 |
2025-06-05 |
エフ． ホフマン－ラ ロシュ アーゲー |
改良された産生細胞
|
|
WO2023246885A1
(zh)
|
2022-06-23 |
2023-12-28 |
江苏恒瑞医药股份有限公司 |
特异性结合dll3和cd3的抗原结合分子及其医药用途
|
|
CA3260989A1
(en)
|
2022-06-30 |
2024-01-04 |
Janssen Biotech, Inc. |
USE OF AN ANTI-EGFR/ANTI-MET ANTIBODY TO TREAT GASTRIC OR ESOPHAGIC CANCER
|
|
EP4565597A2
(en)
|
2022-08-03 |
2025-06-11 |
Voyager Therapeutics, Inc. |
Compositions and methods for crossing the blood brain barrier
|
|
CN119546645A
(zh)
|
2022-08-05 |
2025-02-28 |
江苏恒瑞医药股份有限公司 |
特异性结合gucy2c和cd3的抗原结合分子及其医药用途
|
|
JP2025535203A
(ja)
|
2022-09-15 |
2025-10-23 |
ボイジャー セラピューティクス インコーポレイテッド |
タウ結合化合物
|
|
TW202423970A
(zh)
|
2022-10-10 |
2024-06-16 |
瑞士商赫孚孟拉羅股份公司 |
Ｇｐｒｃ５ｄ ｔｃｂ及ｃｄ３８抗體之組合療法
|
|
TW202430211A
(zh)
|
2022-10-10 |
2024-08-01 |
瑞士商赫孚孟拉羅股份公司 |
Ｇｐｒｃ５ｄ ｔｃｂ及ｉｍｉｄ之組合療法
|
|
TW202423969A
(zh)
|
2022-10-10 |
2024-06-16 |
瑞士商赫孚孟拉羅股份公司 |
Ｇｐｒｃ５ｄ ｔｃｂ及蛋白酶體抑制劑之組合療法
|
|
WO2024079069A1
(en)
|
2022-10-12 |
2024-04-18 |
F. Hoffmann-La Roche Ag |
Method for classifying cells
|
|
WO2024089551A1
(en)
|
2022-10-25 |
2024-05-02 |
Janssen Biotech, Inc. |
Msln and cd3 binding agents and methods of use thereof
|
|
WO2024094660A1
(en)
|
2022-10-31 |
2024-05-10 |
Genmab A/S |
Cd38 antibodies and uses thereof
|
|
WO2024094017A1
(zh)
|
2022-11-01 |
2024-05-10 |
上海齐鲁制药研究中心有限公司 |
一种针对磷脂酰肌醇蛋白聚糖3的双特异性抗体及其应用
|
|
JP2025537692A
(ja)
|
2022-11-02 |
2025-11-20 |
ヤンセン バイオテツク，インコーポレーテツド |
癌を治療する方法
|
|
WO2024100170A1
(en)
|
2022-11-11 |
2024-05-16 |
F. Hoffmann-La Roche Ag |
Antibodies binding to hla-a*02/foxp3
|
|
JP2025539760A
(ja)
|
2022-11-15 |
2025-12-09 |
エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト |
抗原結合分子
|
|
EP4619427A1
(en)
|
2022-11-15 |
2025-09-24 |
F. Hoffmann-La Roche AG |
Recombinant binding proteins with activatable effector domain
|
|
WO2024107752A2
(en)
|
2022-11-15 |
2024-05-23 |
Onestone Therapeutics Llc |
Compositions and methods for immunomodulatory bifunctional fusion molecules
|
|
WO2024114676A1
(zh)
|
2022-11-29 |
2024-06-06 |
江苏恒瑞医药股份有限公司 |
Cldn18.2/4-1bb结合蛋白及其医药用途
|
|
WO2024153725A1
(en)
|
2023-01-20 |
2024-07-25 |
F. Hoffmann-La Roche Ag |
Recombinant fc domain - il2 variant polypeptides and combination therapy with membrane-anchored antigen binding polypeptides
|
|
WO2024156672A1
(en)
|
2023-01-25 |
2024-08-02 |
F. Hoffmann-La Roche Ag |
Antibodies binding to csf1r and cd3
|
|
WO2024163009A1
(en)
|
2023-01-31 |
2024-08-08 |
Genentech, Inc. |
Methods and compositions for treating urothelial bladder cancer
|
|
TW202436339A
(zh)
|
2023-01-31 |
2024-09-16 |
瑞士商赫孚孟拉羅股份公司 |
治療選自非小細胞肺癌或三陰性乳癌的癌症之用途
|
|
WO2024168061A2
(en)
|
2023-02-07 |
2024-08-15 |
Ayan Therapeutics Inc. |
Antibody molecules binding to sars-cov-2
|
|
WO2024175031A1
(zh)
|
2023-02-21 |
2024-08-29 |
江苏恒瑞医药股份有限公司 |
Il-36r结合蛋白及其医药用途
|
|
CN120826234A
(zh)
|
2023-03-06 |
2025-10-21 |
豪夫迈·罗氏有限公司 |
抗EGFRvIII/抗CD3抗体与肿瘤靶向性4-1BB激动剂的组合疗法
|
|
WO2024188965A1
(en)
|
2023-03-13 |
2024-09-19 |
F. Hoffmann-La Roche Ag |
Combination therapy employing a pd1-lag3 bispecific antibody and an hla-g t cell bispecific antibody
|
|
EP4680639A1
(en)
|
2023-03-13 |
2026-01-21 |
Janssen Biotech, Inc. |
Combination therapies with bi-specific anti-egfr/c-met antibodies and anti-pd-1 antibodies
|
|
EP4688840A1
(en)
|
2023-04-03 |
2026-02-11 |
F. Hoffmann-La Roche AG |
Agonistic split antibodies
|
|
EP4688841A1
(en)
|
2023-04-03 |
2026-02-11 |
F. Hoffmann-La Roche AG |
All-in-one agonistic antibodies
|
|
WO2024208898A1
(en)
|
2023-04-05 |
2024-10-10 |
Genmab A/S |
Pharmaceutical compositions comprising antibodies binding to cd30 and cd3
|
|
WO2024213040A1
(zh)
|
2023-04-11 |
2024-10-17 |
浙江博锐生物制药有限公司 |
抗ror1抗体及其药物偶联物
|
|
AU2024269754A1
(en)
|
2023-05-08 |
2025-10-23 |
F. Hoffmann-La Roche Ag |
Targeted interferon alpha fusion proteins and methods of use
|
|
CN121285385A
(zh)
|
2023-05-12 |
2026-01-06 |
金麦安博股份有限公司 |
能够与ox40结合的抗体、其变体及其用途
|
|
WO2024238537A1
(en)
|
2023-05-16 |
2024-11-21 |
F. Hoffmann-La Roche Ag |
Pd-1 -regulated il-2 immunocytokine and uses thereof
|
|
CA3228195A1
(en)
|
2023-05-23 |
2025-06-30 |
Janssen Biotech, Inc. |
Methods for treatment of non-small cell lung cancer (nsclc)
|
|
CN119143869A
(zh)
|
2023-06-16 |
2024-12-17 |
复旦大学 |
乙肝病毒表面抗体及其应用
|
|
WO2024263195A1
(en)
|
2023-06-23 |
2024-12-26 |
Genentech, Inc. |
Methods for treatment of liver cancer
|
|
WO2024263904A1
(en)
|
2023-06-23 |
2024-12-26 |
Genentech, Inc. |
Methods for treatment of liver cancer
|
|
AU2024306598A1
(en)
|
2023-06-30 |
2025-12-11 |
Genmab A/S |
Antibodies binding to fibroblast activation protein alpha and death receptor 4
|
|
US12319747B2
(en)
|
2023-07-03 |
2025-06-03 |
Medicovestor, Inc. |
Methods of using anti-SP17 immunotherapeutics
|
|
WO2025021838A1
(en)
|
2023-07-26 |
2025-01-30 |
F. Hoffmann-La Roche Ag |
Antibodies binding to cd3
|
|
TW202521576A
(zh)
|
2023-07-30 |
2025-06-01 |
美商健生生物科技公司 |
結合至突變型鈣網蛋白之分子及其用途
|
|
WO2025032508A1
(en)
|
2023-08-07 |
2025-02-13 |
Janssen Biotech, Inc. |
Enpp3 and cd3 binding agents and methods of use thereof
|
|
US20250066510A1
(en)
|
2023-08-07 |
2025-02-27 |
Janssen Biotech, Inc. |
Gucy2c antibodies and uses thereof
|
|
WO2025032510A1
(en)
|
2023-08-07 |
2025-02-13 |
Janssen Biotech, Inc. |
Stabilized cd3 antigen binding agents and methods of use thereof
|
|
WO2025032071A1
(en)
|
2023-08-09 |
2025-02-13 |
F. Hoffmann-La Roche Ag |
Mono and multispecific anti-trem2 antibodies, methods and uses thereof
|
|
AU2024323186A1
(en)
|
2023-08-09 |
2026-01-15 |
F. Hoffmann-La Roche Ag |
Mono and multispecific anti-trem2 antibodies, methods and uses thereof
|
|
WO2025036892A1
(en)
|
2023-08-14 |
2025-02-20 |
Morphosys Ag |
Cycat halfbody molecules comprising sterically occluding moieties
|
|
WO2025036910A1
(en)
|
2023-08-15 |
2025-02-20 |
Merck Patent Gmbh |
Novel c-met binders and uses thereof
|
|
WO2025042742A1
(en)
|
2023-08-18 |
2025-02-27 |
Bristol-Myers Squibb Company |
Compositions comprising antibodies that bind bcma and cd3 and methods of treatment
|
|
WO2025052273A1
(en)
|
2023-09-05 |
2025-03-13 |
Janssen Biotech, Inc. |
Methods of treating non-small cell lung cancer
|
|
WO2025056180A1
(en)
|
2023-09-15 |
2025-03-20 |
BioNTech SE |
Methods of treatment using agents binding to epcam and cd137 in combination with pd-1 axis binding antagonists
|
|
WO2025079020A1
(en)
|
2023-10-12 |
2025-04-17 |
Janssen Biotech, Inc. |
First line treatment in egfr exon 20 insertion-mutated advanced non-small cell lung cancer
|
|
WO2025082777A1
(en)
|
2023-10-17 |
2025-04-24 |
Morphosys Ag |
Dual-targeting of muc16 and mesothelin co-expressing tumor cells by functional complementation of cycat® halfbody molecules
|
|
US12364777B2
(en)
|
2023-10-20 |
2025-07-22 |
Medicovestor, Inc. |
Homodimeric antibodies for use in treating cancers and methods of use
|
|
TW202540189A
(zh)
|
2023-11-30 |
2025-10-16 |
德商生物新技術公司 |
在組合療法中能夠結合ｏｘ４０之抗體
|
|
WO2025122634A1
(en)
|
2023-12-05 |
2025-06-12 |
Voyager Therapeutics, Inc. |
Compositions and methods for the treatment of tau-related disorders
|
|
WO2025126102A1
(en)
|
2023-12-12 |
2025-06-19 |
Janssen Biotech, Inc. |
Enpp3 × cd3 bispecific antibodies and use thereof
|
|
WO2025125386A1
(en)
|
2023-12-14 |
2025-06-19 |
F. Hoffmann-La Roche Ag |
Antibodies that bind to folr1 and methods of use
|
|
US12116410B1
(en)
|
2023-12-26 |
2024-10-15 |
Medicovestor, Inc. |
Methods of manufacturing dimeric antibodies
|
|
US12121587B1
(en)
|
2023-12-26 |
2024-10-22 |
Medicovestor, Inc. |
Dimeric antibodies
|
|
WO2025153988A1
(en)
|
2024-01-16 |
2025-07-24 |
Janssen Biotech, Inc. |
Use of amivantamab to treat colorectal cancer
|
|
WO2025158277A1
(en)
|
2024-01-22 |
2025-07-31 |
Janssen Biotech, Inc. |
Use of amivantamab to treat head and neck cancer
|
|
US12258396B1
(en)
|
2024-02-02 |
2025-03-25 |
Medicovestor, Inc. |
Methods of using immunotherapeutics that bind folate receptor alpha
|
|
US12240900B1
(en)
|
2024-02-02 |
2025-03-04 |
Medicovestor, Inc. |
Nucleic acids, vectors, and cells that encode antibodies and other proteins that bind folate receptor alpha
|
|
US12378314B1
(en)
|
2024-02-02 |
2025-08-05 |
Medicovestor, Inc. |
Proteins that bind folate receptor alpha including fully-human antibodies
|
|
WO2025181189A1
(en)
|
2024-03-01 |
2025-09-04 |
F. Hoffmann-La Roche Ag |
Antibodies binding to cd3
|
|
WO2025191459A1
(en)
|
2024-03-11 |
2025-09-18 |
Janssen Biotech, Inc. |
Use of bispecific anti-egfr/c-met antibodies to treat solid tumors
|
|
WO2025202147A1
(en)
|
2024-03-27 |
2025-10-02 |
F. Hoffmann-La Roche Ag |
Interleukin-7 immunoconjugates
|
|
WO2025219504A1
(en)
|
2024-04-19 |
2025-10-23 |
F. Hoffmann-La Roche Ag |
Treatment of ophthalmologic diseases
|
|
WO2025231408A2
(en)
|
2024-05-03 |
2025-11-06 |
Janssen Biotech, Inc. |
Methods for treating multiple myeloma with car-t cells and bispecific antibodies
|
|
WO2025233825A1
(en)
|
2024-05-06 |
2025-11-13 |
Janssen Pharmaceutica Nv |
Enrichment of cells expressing a bird linker
|
|
WO2025237931A1
(en)
|
2024-05-15 |
2025-11-20 |
F. Hoffmann-La Roche Ag |
Recombinant binding proteins with conditionally activatable t cell and nk cell recruiting effector domains
|
|
WO2026003224A2
(en)
|
2024-06-26 |
2026-01-02 |
Iomx Therapeutics Ag |
Bispecific antigen binding proteins (abp) targeting immune checkpoint molecules and both leukocyte immunoglobulin-like receptor subfamily b1 (lilrb1) and lilrb2; combinations and uses thereof
|
|
WO2026011013A1
(en)
|
2024-07-02 |
2026-01-08 |
Epibiologics, Inc. |
Binding agents and uses thereof
|