BE2012C005I2 - - Google Patents
Download PDFInfo
- Publication number
- BE2012C005I2 BE2012C005I2 BE2012C005C BE2012C005C BE2012C005I2 BE 2012C005 I2 BE2012C005 I2 BE 2012C005I2 BE 2012C005 C BE2012C005 C BE 2012C005C BE 2012C005 C BE2012C005 C BE 2012C005C BE 2012C005 I2 BE2012C005 I2 BE 2012C005I2
- Authority
- BE
- Belgium
- Prior art keywords
- blys
- antibodies
- present disclosure
- related molecules
- immunospecifically bind
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Rheumatology (AREA)
- Pathology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Food Science & Technology (AREA)
- Diabetes (AREA)
- General Physics & Mathematics (AREA)
- Endocrinology (AREA)
- Analytical Chemistry (AREA)
- Rehabilitation Therapy (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21221000P | 2000-06-16 | 2000-06-16 | |
US24081600P | 2000-10-17 | 2000-10-17 | |
US27624801P | 2001-03-16 | 2001-03-16 | |
US27737901P | 2001-03-21 | 2001-03-21 | |
US29349901P | 2001-05-25 | 2001-05-25 | |
PCT/US2001/019110 WO2002002641A1 (fr) | 2000-06-16 | 2001-06-15 | Anticorps se liant de maniere immunospecifique a un stimulateur de lymphocyte b |
Publications (1)
Publication Number | Publication Date |
---|---|
BE2012C005I2 true BE2012C005I2 (fr) | 2020-08-20 |
Family
ID=27539647
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE2012C005C BE2012C005I2 (fr) | 2000-06-16 | 2012-01-12 |
Country Status (20)
Country | Link |
---|---|
US (4) | US7138501B2 (fr) |
EP (4) | EP2281842A1 (fr) |
JP (2) | JP4902087B2 (fr) |
KR (4) | KR101287395B1 (fr) |
CN (1) | CN1279055C (fr) |
AT (1) | ATE494304T1 (fr) |
AU (3) | AU6842701A (fr) |
BE (1) | BE2012C005I2 (fr) |
CA (1) | CA2407910C (fr) |
CY (4) | CY1112793T1 (fr) |
DE (1) | DE60143798D1 (fr) |
DK (1) | DK1294769T3 (fr) |
ES (3) | ES2358885T3 (fr) |
FR (1) | FR12C0001I2 (fr) |
HK (1) | HK1051697A1 (fr) |
LU (1) | LU91926I2 (fr) |
MX (1) | MXPA02012434A (fr) |
NZ (1) | NZ522700A (fr) |
PT (2) | PT2275449T (fr) |
WO (1) | WO2002002641A1 (fr) |
Families Citing this family (209)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8212004B2 (en) | 1999-03-02 | 2012-07-03 | Human Genome Sciences, Inc. | Neutrokine-alpha fusion proteins |
US6812327B1 (en) * | 1996-10-25 | 2004-11-02 | Human Genome Sciences, Inc. | Neutrokine-alpha polypeptides |
US7244826B1 (en) * | 1998-04-24 | 2007-07-17 | The Regents Of The University Of California | Internalizing ERB2 antibodies |
NZ513284A (en) | 1999-01-25 | 2003-10-31 | Biogen Inc | BAFF blocking agents and their use in the stimulation and inhibition of B-cells and immunoglobulins in immune responses |
US20030095967A1 (en) | 1999-01-25 | 2003-05-22 | Mackay Fabienne | BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders |
CA2362204C (fr) | 1999-02-17 | 2011-11-08 | John Cooper Cox | Complexes immunogenes et methodes y relatives |
NZ517782A (en) | 1999-08-17 | 2004-01-30 | Biogen Inc | A beta-cell activating factor receptor belonging to the TNF family is used as a pharmaceutical agent and in the treatment of disease |
UA74798C2 (uk) | 1999-10-06 | 2006-02-15 | Байоджен Айдек Ма Інк. | Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами |
US7220840B2 (en) * | 2000-06-16 | 2007-05-22 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to B lymphocyte stimulator protein |
CA2407910C (fr) * | 2000-06-16 | 2013-03-12 | Steven M. Ruben | Anticorps se liant de maniere immunospecifique a un stimulateur de lymphocyte b |
US7879328B2 (en) * | 2000-06-16 | 2011-02-01 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to B lymphocyte stimulator |
EP2267016A3 (fr) * | 2000-08-18 | 2011-04-20 | Human Genome Sciences, Inc. | Polypeptides de liaison pour la protéine stimulatrice des lymphocytes B (BLyS) |
WO2002016411A2 (fr) | 2000-08-18 | 2002-02-28 | Human Genome Sciences, Inc. | Polypeptides de fixation et procedes associes |
UA83458C2 (uk) | 2000-09-18 | 2008-07-25 | Байоджен Айдек Ма Інк. | Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf) |
GB0024200D0 (en) * | 2000-10-03 | 2000-11-15 | Smithkline Beecham Sa | Component vaccine |
WO2002079377A2 (fr) * | 2000-11-08 | 2002-10-10 | Human Genome Sciences, Inc. | Anticorps a liaison immunospecifique avec les recepteurs 'trail' |
US20030119056A1 (en) | 2000-12-18 | 2003-06-26 | Ladner Robert Charles | Focused libraries of genetic packages |
ES2376454T3 (es) * | 2000-12-22 | 2012-03-14 | Grad, Carole, Legal Representative Of Howard, Kaplan | Librer�?as de expresión en fago de fragmentos vh humanos. |
JP2004537290A (ja) * | 2001-05-24 | 2004-12-16 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | 腫瘍壊死因子δ(APRIL)に対する抗体 |
US7348003B2 (en) | 2001-05-25 | 2008-03-25 | Human Genome Sciences, Inc. | Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors |
US7361341B2 (en) | 2001-05-25 | 2008-04-22 | Human Genome Sciences, Inc. | Methods of treating cancer using antibodies that immunospecifically bind to trail receptors |
MXPA03010747A (es) * | 2001-05-25 | 2004-03-02 | Human Genome Sciences Inc | Anticuerpos que se unen inmunoespecificamente a receptores de ligando inductor de apoptosis relacionado con factor de necrosis tumoral. |
JP2004538324A (ja) | 2001-08-03 | 2004-12-24 | メディカル リサーチ カウンシル | 細胞内抗体 |
AR035119A1 (es) | 2001-08-16 | 2004-04-14 | Lilly Co Eli | Anticuerpos humanos antagonistas anti-htnfsf13b |
US7112410B1 (en) * | 2001-08-29 | 2006-09-26 | Human Genome Sciences, Inc. | Human tumor necrosis factor TR21 and methods based thereon |
US7658924B2 (en) * | 2001-10-11 | 2010-02-09 | Amgen Inc. | Angiopoietin-2 specific binding agents |
US7521053B2 (en) * | 2001-10-11 | 2009-04-21 | Amgen Inc. | Angiopoietin-2 specific binding agents |
US20030157522A1 (en) * | 2001-11-09 | 2003-08-21 | Alain Boudreault | Methods and reagents for peptide-BIR interaction screens |
WO2003055979A2 (fr) * | 2001-11-16 | 2003-07-10 | Human Genome Sciences, Inc. | Anticorps se liant à blys selon un mode immunospécifique |
AU2002357359B2 (en) * | 2001-12-21 | 2009-01-08 | Csl Limited | Compositions comprising immunoreactive reagents and saponins, and methods of use thereof |
CN1652821A (zh) * | 2002-01-28 | 2005-08-10 | 米德列斯公司 | 抗前列腺特异性膜抗原(psma)的人单克隆抗体 |
CA2481401A1 (fr) * | 2002-04-15 | 2003-10-30 | Human Genome Sciences, Inc. | Anticorps se liant specifiquement au tl5 |
WO2003105782A2 (fr) * | 2002-06-17 | 2003-12-24 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Greffage par specificite d'un anticorps murin sur une charpente humaine |
US7601351B1 (en) | 2002-06-26 | 2009-10-13 | Human Genome Sciences, Inc. | Antibodies against protective antigen |
CA2490280A1 (fr) * | 2002-07-01 | 2004-01-08 | Human Genome Sciences, Inc. | Anticorps qui se lient specifiquement a reg iv |
CA2491669A1 (fr) | 2002-07-04 | 2004-01-15 | Oncomab Gmbh | Anticorps specifiques de neoplasme et utilisations associees |
CA2492457A1 (fr) * | 2002-08-02 | 2004-02-12 | Craig A. Rosen | Anticorps diriges contre le recepteur c3a |
CN1829730A (zh) * | 2002-11-12 | 2006-09-06 | 贝克顿迪金森公司 | 使用生物标记谱诊断脓毒或者sirs |
US7396915B2 (en) | 2003-02-28 | 2008-07-08 | Mitsubishi Pharma Corporation | Monoclonal antibody and gene encoding the same, hybridoma, pharmaceutical composition, and diagnostic reagent |
JP4914209B2 (ja) | 2003-03-14 | 2012-04-11 | ワイス | ヒトil−21受容体に対する抗体および該抗体の使用 |
DE10311248A1 (de) * | 2003-03-14 | 2004-09-30 | Müller-Hermelink, Hans Konrad, Prof. Dr. | Humaner monoklonaler Antikörper |
US7700317B2 (en) | 2003-03-28 | 2010-04-20 | Biogen Idec Ma Inc. | Truncated baff receptors |
KR100988129B1 (ko) * | 2003-04-30 | 2010-10-18 | 쥬리디컬 파운데이션 더 케모-세로-쎄라퓨틱 리서치 인스티튜트 | 인간 항인간 인터루킨-18 항체와 그 단편, 및 이들의이용방법 |
NZ543712A (en) | 2003-06-05 | 2008-06-30 | Genentech Inc | Combination therapy for B cell disorders |
US7628986B2 (en) | 2003-06-27 | 2009-12-08 | Amgen Fremont Inc. | Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof |
AR045563A1 (es) | 2003-09-10 | 2005-11-02 | Warner Lambert Co | Anticuerpos dirigidos a m-csf |
WO2005049802A2 (fr) * | 2003-11-14 | 2005-06-02 | Massachusetts Institute Of Technology | Anticorps anti-hydroxylase et utilisations |
EP1531162A1 (fr) | 2003-11-14 | 2005-05-18 | Heinz Vollmers | Anticorps SAM-6, spécifique d'adénocarcinome, et ses utilisations |
DE10353175A1 (de) | 2003-11-14 | 2005-06-16 | Müller-Hermelink, Hans Konrad, Prof. Dr. | Humaner monoklonaler Antikörper mit fettsenkender Wirkung |
WO2005075511A1 (fr) * | 2004-01-29 | 2005-08-18 | Genentech, Inc. | Variants du domaine extracellulaire de bcma et utilisations de ceux-ci |
EP1737487B1 (fr) * | 2004-03-30 | 2016-05-25 | Canadian Blood Services | Methode servant a traiter des maladies auto-immunes au moyen d'anticorps |
CN101921340A (zh) * | 2004-03-31 | 2010-12-22 | 佳能株式会社 | 一种蛋白质 |
JPWO2005105998A1 (ja) * | 2004-04-27 | 2008-07-31 | 財団法人化学及血清療法研究所 | ヒト抗アミロイドβペプチド抗体およびその抗体フラグメント |
WO2005108986A1 (fr) * | 2004-05-10 | 2005-11-17 | Korea Research Institute Of Bioscience And Biotechnology | Procede de diagnostic de l'asthme au moyen de baff utilise comme marqueur diagnostique |
GB0417487D0 (en) | 2004-08-05 | 2004-09-08 | Novartis Ag | Organic compound |
US20080050381A1 (en) * | 2004-08-31 | 2008-02-28 | Tsutomu Takeuchi | Antihuman Baff Antibody |
EP1799260A4 (fr) * | 2004-09-29 | 2011-09-28 | Centocor Inc | Anticorps anti- amyloide, compositions, techniques et utilisations |
NZ560285A (en) * | 2005-01-28 | 2011-04-29 | Biogen Idec Inc | Use of baff to treat Th2-mediated conditions |
US20070009972A1 (en) * | 2005-02-16 | 2007-01-11 | Ginger Chao | Epidermal growth factor receptor polypeptides and antibodies |
EP2333066B1 (fr) * | 2005-03-25 | 2015-02-18 | National Research Council of Canada | Procédé d'isolation de polypeptides solubles |
AU2011247831B8 (en) * | 2005-03-25 | 2014-02-20 | National Research Council Of Canada | Method for isolation of soluble polypeptides |
AU2006236588A1 (en) | 2005-04-15 | 2006-10-26 | Becton, Dickinson And Company | Diagnosis of sepsis |
US20060240006A1 (en) * | 2005-04-20 | 2006-10-26 | Chishih Chu | Novel antibody structures derived from human germline sequences |
NZ597082A (en) * | 2005-10-13 | 2013-11-29 | Human Genome Sciences Inc | Methods and Compositions for Use in Treatment of Patients with Autoantibody Positive Diseases |
US9168286B2 (en) * | 2005-10-13 | 2015-10-27 | Human Genome Sciences, Inc. | Methods and compositions for use in treatment of patients with autoantibody positive disease |
JP4736037B2 (ja) * | 2005-10-26 | 2011-07-27 | 株式会社イーベック | ヒトgm−csfに結合するヒトのモノクローナル抗体並びにその抗原結合部分 |
AU2006318539B2 (en) * | 2005-11-23 | 2012-09-13 | Genentech, Inc. | Methods and compositions related to B cell assays |
AU2007209201A1 (en) * | 2006-01-24 | 2007-08-02 | Domantis Limited | Fusion proteins that contain natural junctions |
TW200745163A (en) | 2006-02-17 | 2007-12-16 | Syntonix Pharmaceuticals Inc | Peptides that block the binding of IgG to FcRn |
WO2007123765A2 (fr) | 2006-03-31 | 2007-11-01 | Human Genome Sciences Inc. | NEUTROKINE-ALPHA et variant d'epissage de la neutrokine-alpha |
JP2007306828A (ja) * | 2006-05-17 | 2007-11-29 | Tokai Univ | 非還元マンノース残基を認識するファージ提示型単鎖抗体 |
US7981417B2 (en) * | 2006-06-07 | 2011-07-19 | Wisconsin Alumni Research Foundation | Blood-brain barrier targeting anti-bodies |
CA2653444A1 (fr) * | 2006-06-07 | 2007-12-13 | Wisconsin Alumni Research Foundation | Anticorps ciblant la barriere hemato-encephalique |
EP2078732B1 (fr) * | 2006-07-10 | 2015-09-16 | Fujita Health University | Procédé pour l'identification des anticorps diagnostic ou thérapeutiques par cytométrie en flux |
CA2665644A1 (fr) * | 2006-10-12 | 2008-05-29 | Genentech, Inc. | Anticorps de la lymphotoxine-alpha |
WO2008140483A2 (fr) * | 2006-11-09 | 2008-11-20 | Human Genome Sciences, Inc. | Procédés et anticorps pour détecter un antigène protecteur |
PL2104682T3 (pl) | 2007-01-11 | 2017-03-31 | Michael Bacher | Diagnostyka i leczenie choroby Alzheimera i innych chorób neurodegeneracyjnych |
WO2009029132A2 (fr) * | 2007-05-31 | 2009-03-05 | Merck & Co., Inc. | PROTÉINES DE LIAISON À L'ANTIGÈNE CIBLANT L'ORF0657n DE S. AUREUS |
CL2008002153A1 (es) | 2007-07-24 | 2009-06-05 | Amgen Inc | Anticuerpo aislado o fragmanto de unión de antigeno del mismo que se une al receptor de il-18 (il-18r); molecula de ácido nucleico codificante; celula huesped que la comprende; composición farmaceutica; uso médico para tratar o prevenir una condición asociada con il-18r; método in vitro para inhibir la unión de il-18 al il-18r. |
CA2695237A1 (fr) * | 2007-08-02 | 2009-04-30 | Novimmune S.A. | Anticorps anti-rantes et leurs procedes d'utilisation |
KR20100040951A (ko) | 2007-08-09 | 2010-04-21 | 신토닉스 파마수티칼스, 인코포레이티드 | 면역조절성 펩티드 |
AR068767A1 (es) | 2007-10-12 | 2009-12-02 | Novartis Ag | Anticuerpos contra esclerostina, composiciones y metodos de uso de estos anticuerpos para tratar un trastorno patologico mediado por esclerostina |
PL2233149T3 (pl) | 2007-10-16 | 2016-08-31 | Zymogenetics Inc | Kombinacja przezbłonowego aktywatora i ligandu cyklofiliny (taci) oraz przeciwciała anty-cd20 do leczenia chorób autoimmunologicznych |
UY31466A1 (es) * | 2007-11-13 | 2009-07-17 | Anticuerpos monoclonales que se unen al hgm-csf y las composiciones médicas que los comprenden | |
JO2913B1 (en) | 2008-02-20 | 2015-09-15 | امجين إنك, | Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses |
US8669113B2 (en) | 2008-04-03 | 2014-03-11 | Becton, Dickinson And Company | Advanced detection of sepsis |
BRPI0911431B8 (pt) * | 2008-04-11 | 2021-05-25 | Chugai Pharmaceutical Co Ltd | composição farmacêutica compreendendo um antígeno e método para aumentar o número de antígenos que podem ser ligados por um anticorpo |
CA2721202A1 (fr) * | 2008-04-17 | 2009-10-22 | Hilde Adi Pierrette Revets | Peptides capables de se lier a des proteines seriques et composes, constructions et polypeptides les comprenant |
AU2009239437B2 (en) | 2008-04-25 | 2014-11-13 | University Of Washington | Levels of BCMA protein expression on B cells and use in diagnostic methods |
US8003335B2 (en) | 2008-04-30 | 2011-08-23 | Universite Paris-SUD11 | Levels of APRIL in serum and use in diagnostic methods |
PL2291657T3 (pl) | 2008-05-01 | 2016-09-30 | Stężenie heterotrimerów blys/april w surowicy oraz zastosowanie w sposobach diagnostycznych | |
US20100322936A1 (en) * | 2008-06-16 | 2010-12-23 | Patrys Limited | Lm-1 antibodies, functional fragments, lm-1 target antigen, and methods for making and using same |
UA112050C2 (uk) * | 2008-08-04 | 2016-07-25 | БАЄР ХЕЛСКЕР ЛЛСі | Терапевтична композиція, що містить моноклональне антитіло проти інгібітора шляху тканинного фактора (tfpi) |
AR072999A1 (es) * | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
EP2344541A2 (fr) * | 2008-09-19 | 2011-07-20 | MedImmune, LLC | Agents de liaison ciblés dirigés sur cd105 et leurs utilisations |
TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
EP2376120A2 (fr) | 2008-11-25 | 2011-10-19 | Biogen Idec MA Inc. | Utilisation d'antagonistes dr6 et p75 pour favoriser la survie de cellules du systeme nerveux |
WO2010075249A2 (fr) | 2008-12-22 | 2010-07-01 | Genentech, Inc. | Méthode de traitement de la polyarthrite rhumatoïde avec des antagonistes de cellules b |
WO2010093993A2 (fr) * | 2009-02-12 | 2010-08-19 | Human Genome Sciences, Inc. | Utilisation d'antagonistes de la protéine stimulant les lymphocytes b afin de favoriser la tolérance aux greffes |
RU2595379C2 (ru) * | 2009-04-16 | 2016-08-27 | АббВай Биотерапеутикс Инк. | АНТИТЕЛА ПРОТИВ TNF-α И ИХ ПРИМЕНЕНИЯ |
WO2010141249A2 (fr) * | 2009-06-02 | 2010-12-09 | Merck Sharp & Dohme Corp. | Génération, caractérisation et utilisations d'anticorps anti-notch3 |
RU2539112C2 (ru) | 2009-09-03 | 2015-01-10 | Дженентек, Инк. | Способы лечения, диагностики и мониторинга ревматоидного артрита |
PT2542257T (pt) | 2010-03-01 | 2017-10-09 | Bayer Healthcare Llc | Anticorpos monoclonais otimizados contra inibidor da via do fator tecidual (tfpi) |
WO2011109280A1 (fr) | 2010-03-05 | 2011-09-09 | Lerner Research Institute | Procédés et compositions permettant de traiter les troubles d'origines immunes |
WO2011139375A1 (fr) * | 2010-05-06 | 2011-11-10 | Ludwig Institute For Cancer Research Ltd | Anticorps dirigés contre l'anhydrase carbonique ix et méthodes et utilisations associées |
WO2011160086A2 (fr) * | 2010-06-18 | 2011-12-22 | Human Genome Sciences, Inc. | Utilisation d'antagonistes d'une protéine stimulant les lymphocytes b en vue du traitement de l'asthme et d'autres affections allergiques et inflammatoires du système respiratoire |
CA2806076A1 (fr) | 2010-07-22 | 2012-01-26 | The Regents Of The University Of California | Anticorps-antigenes antitumoraux et methodes d'utilisation correspondantes |
AP3584A (en) | 2010-09-22 | 2016-02-09 | Alios Biopharma Inc | Substituted nucleotide analogs |
WO2012047583A2 (fr) * | 2010-09-27 | 2012-04-12 | Janssen Biotech, Inc. | Anticorps se liant au collagène humain de type ii |
US8906649B2 (en) | 2010-09-27 | 2014-12-09 | Janssen Biotech, Inc. | Antibodies binding human collagen II |
JP6030452B2 (ja) | 2010-11-30 | 2016-11-24 | 中外製薬株式会社 | 複数分子の抗原に繰り返し結合する抗原結合分子 |
WO2012099973A2 (fr) * | 2011-01-18 | 2012-07-26 | The Trustees Of The University Of Pennsylvania | Compositions et procédés de traitement du cancer |
KR20230005405A (ko) | 2011-02-25 | 2023-01-09 | 추가이 세이야쿠 가부시키가이샤 | FcγRIIb 특이적 Fc 항체 |
EP2680884B1 (fr) | 2011-02-28 | 2018-01-17 | F. Hoffmann-La Roche AG | Marqueurs biologiques et procédés de prédiction de réponse à des antagonistes de lymphocytes b |
DE102011006809A1 (de) | 2011-04-05 | 2012-10-11 | Freistaat Bayern vertreten durch die Julius-Maximilians-Universität Würzburg | Verwendung eines Mittels aus Antikörpern und/oder Insulin-like growth factor-Antagonisten |
ES3005912T3 (en) | 2011-07-22 | 2025-03-17 | Csl Behring Gmbh | Inhibitory anti-factor xii/xiia monoclonal antibodies and their uses |
JP6277126B2 (ja) * | 2011-08-09 | 2018-02-07 | アセラ・バイオテクノロジーズ・アーベー | ホスホリルコリン(pc)および/またはpcコンジュゲートに結合する抗体 |
WO2013047748A1 (fr) | 2011-09-30 | 2013-04-04 | 中外製薬株式会社 | Molécule se liant à l'antigène favorisant la disparition des antigènes ayant une pluralité d'activités biologiques |
TW201326209A (zh) | 2011-09-30 | 2013-07-01 | Chugai Pharmaceutical Co Ltd | 具有促進抗原清除之FcRn結合域的治療性抗原結合分子 |
CA2860234A1 (fr) | 2011-12-22 | 2013-06-27 | Alios Biopharma, Inc. | Analogues de nucleotide phosphorothioate substitue |
US9175072B2 (en) * | 2011-12-22 | 2015-11-03 | Elwha Llc | Compositions and methods including recombinant B lymphocyte cell line including an exogenously incorporated nucleic acid expressing an exogenous membrane immunoglobulin reactive to a first antigen and including an endogenous gene expressing an endogenous secreted immunoglobulin reactive to a second antigen |
US10233424B2 (en) | 2011-12-22 | 2019-03-19 | Elwha Llc | Compositions and methods including cytotoxic B lymphocyte cell line expressing exogenous membrane immunoglobulin different from secreted immunoglobulin |
US10745468B2 (en) * | 2011-12-22 | 2020-08-18 | Kota Biotherapeutics, Llc | Compositions and methods for modified B cells expressing reassigned biological agents |
US8962315B2 (en) | 2011-12-22 | 2015-02-24 | Elwha Llc | Compositions and methods including recombinant B lymphocyte cell line including at least one endogenous gene expressing at least one endogenous membrane immunoglobulin reactive to a first antigen and including at least one exogenously incorporated nucleic acid expressing at least one exogenous secreted immunoglobulin reactive to a second antigen |
WO2013106572A1 (fr) | 2012-01-11 | 2013-07-18 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University | Fragments d'anticorps bispécifiques pour protéines associées à une maladie neurologique, et procédés d'utilisation |
US8916538B2 (en) | 2012-03-21 | 2014-12-23 | Vertex Pharmaceuticals Incorporated | Solid forms of a thiophosphoramidate nucleotide prodrug |
EP2827876A4 (fr) | 2012-03-22 | 2015-10-28 | Alios Biopharma Inc | Combinaisons pharmaceutiques comprenant un analogue thionucléotidique |
US9107904B2 (en) * | 2012-04-05 | 2015-08-18 | Massachusetts Institute Of Technology | Immunostimulatory compositions and methods of use thereof |
CN103421113B (zh) * | 2012-05-22 | 2018-01-19 | 武汉华鑫康源生物医药有限公司 | 抗BLyS抗体 |
US10174107B2 (en) | 2012-05-31 | 2019-01-08 | Sorrento Therapeutics, Inc. | Antigen binding proteins that bind delta-like 4 (DLL-4) |
AR091649A1 (es) | 2012-07-02 | 2015-02-18 | Bristol Myers Squibb Co | Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos |
CA2881966C (fr) | 2012-08-24 | 2020-10-06 | The Regents Of The University Of California | Anticorps et vaccins utilisables en vue du traitement de cancers ror1 et de l'inhibition de la metastase |
EA201590459A1 (ru) * | 2012-09-12 | 2015-11-30 | Нейриммьюн Холдинг Аг | Специфические антитела к островковому амилоидному полипептиду человека (hiapp) и их применение |
CN104045713B (zh) * | 2013-03-13 | 2019-02-12 | 江苏诺迈博生物医药科技有限公司 | 一种抗Blys的单克隆抗体及含有该抗体的药物组合物 |
US9458246B2 (en) * | 2013-03-13 | 2016-10-04 | Amgen Inc. | Proteins specific for BAFF and B7RP1 |
PH12022550138A1 (en) * | 2013-03-13 | 2023-03-06 | Amgen Inc | Proteins specific for baff and b7rp1 and uses thereof |
BR112015021399A2 (pt) | 2013-03-14 | 2017-07-18 | Bayer Healthcare Llc | anticórpos monoclonais contra antitrombina beta complexada com heparina |
PT3508502T (pt) | 2013-09-20 | 2023-06-22 | Bristol Myers Squibb Co | Combinação de anticorpos anti-lag-3 e anticorpos anti-pd-1 para tratar tumores |
BR112016014072B1 (pt) | 2013-12-17 | 2023-12-26 | Kling Biotherapeutics B.V. | Anticorpo isolado, sintético ou recombinante humano, ou uma parte funciona do mesmo, molécula de ácido nucleico isolado, vetor, composição, uso de um anticorpo ou parte funcional, ou uma molécula de ácido nucleico ou um vetor e, métodos para produzir um anticorpo ou parte funcional, e para determinar se céuluas aml ou células de linfoma ou células de mieloma múltiplo ou células b de linfoma não hodgkin estão presentes em uma amostra |
JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
CN104804091B (zh) * | 2014-01-29 | 2018-03-27 | 普瑞金(深圳)生物技术有限公司 | 一种抗b细胞生长刺激因子的纳米抗体及用途 |
CN104804090B (zh) * | 2014-01-29 | 2018-03-27 | 普瑞金(深圳)生物技术有限公司 | 一种抗b细胞生长刺激因子的纳米抗体和用途 |
CN104804092B (zh) * | 2014-01-29 | 2018-03-27 | 天津胜发生物技术有限公司 | 一种抗b细胞生长刺激因子的纳米抗体及其用途 |
JP6511459B2 (ja) | 2014-01-31 | 2019-05-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規な抗baff抗体 |
SI3116909T1 (sl) | 2014-03-14 | 2020-03-31 | Novartis Ag | Molekule protiteles na LAG-3 in njih uporaba |
US10758526B2 (en) | 2014-06-09 | 2020-09-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services National Institutes Of Health | Combination therapies using agents that target tumor-associated stroma or tumor cells and other pathways |
US11034757B2 (en) | 2014-06-09 | 2021-06-15 | Biomed Valley Discoveries, Inc. | Combination therapies using agents that target tumor-associated stroma or tumor cells and tumor vasculature |
US10434174B2 (en) | 2014-06-09 | 2019-10-08 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Combination therapies using platinum agents and agents that target tumor-associated stroma or tumor cells |
WO2015191590A2 (fr) * | 2014-06-09 | 2015-12-17 | Biomed Valley Discoveries, Inc. | Polythérapies ciblant des stromas associés à une tumeur ou des cellules tumorales et des microtubules |
US10758614B2 (en) | 2014-06-09 | 2020-09-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services National Institutes Of Health | Combination therapies targeting tumor-associated stroma or tumor cells and topoisomerase |
WO2015191615A2 (fr) * | 2014-06-09 | 2015-12-17 | Biomed Valley Discoveries, Inc. | Polythérapies utilisant des agents qui ciblent un stroma associé à une tumeur ou des cellules tumorales et des agents alkylants |
WO2015191602A2 (fr) * | 2014-06-09 | 2015-12-17 | Biomed Valley Discoveries, Inc. | Polythérapies ciblant un stroma associé à une tumeur ou des cellules tumorales |
US10758613B2 (en) | 2014-06-09 | 2020-09-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services National Intstitutes Of Health | Combination therapies using anti-metabolites and agents that target tumor-associated stroma or tumor cells |
US9683017B2 (en) | 2014-07-17 | 2017-06-20 | University Tennessee Research Foundation | Inhibitory peptides of viral infection |
WO2016032949A1 (fr) | 2014-08-26 | 2016-03-03 | University Of Tennessee Research Foundation | Immunothérapie de ciblage de l'amyloïdose |
EP3215175A4 (fr) * | 2014-11-06 | 2018-06-27 | Scholar Rock, Inc. | Anticorps anti-pro-myostatine/myostatine latente et leurs utilisations |
HRP20211978T1 (hr) | 2014-12-05 | 2022-04-01 | Memorial Sloan-Kettering Cancer Center | Kimerični antigenski receptori koji ciljaju receptor spojen na g-protein i njihove uporabe |
MX2017007246A (es) * | 2014-12-05 | 2018-01-25 | Memorial Sloan Kettering Cancer Center | Anticuerpos orientados al antigeno de maduracion de celula b y metodos de uso. |
MX2017007249A (es) | 2014-12-05 | 2018-01-25 | Memorial Sloan Kettering Cancer Center | Receptores de antigeno quimerico dirigidos al receptor fc 5 similar y sus usos. |
IL295298A (en) | 2014-12-05 | 2022-10-01 | Memorial Sloan Kettering Cancer Center | All B-cell maturation antigen-directed chimeric antigen receptors and their uses |
CA2967554A1 (fr) | 2014-12-19 | 2016-06-23 | Yoshinao Ruike | Anticorps anti-c5 et leurs procedes d'utilisation |
KR102650420B1 (ko) | 2014-12-19 | 2024-03-21 | 추가이 세이야쿠 가부시키가이샤 | 항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법 |
JP6865688B2 (ja) | 2015-01-16 | 2021-04-28 | ジュノー セラピューティクス インコーポレイテッド | Ror1に特異的な抗体およびキメラ抗原受容体 |
TW202248212A (zh) | 2015-02-05 | 2022-12-16 | 日商中外製藥股份有限公司 | 包含離子濃度依賴之抗原結合域的抗體、Fc區變體、IL-8結合抗體與其用途 |
CN108271359B (zh) * | 2015-02-13 | 2021-11-09 | 索伦托药业有限公司 | 结合ctla4的抗体治疗剂 |
RU2730590C2 (ru) | 2015-02-27 | 2020-08-24 | Чугаи Сейяку Кабусики Кайся | Композиция для лечения заболеваний, связанных с ил-6 |
AR104368A1 (es) | 2015-04-03 | 2017-07-19 | Lilly Co Eli | Anticuerpos biespecíficos anti-cd20- / anti-baff |
WO2016164530A1 (fr) * | 2015-04-07 | 2016-10-13 | University Of Maryland, College Park | Compositions et procédés pour le séquençage de protéines à haut débit |
CN113527495A (zh) | 2015-04-08 | 2021-10-22 | 索伦托药业有限公司 | 与cd38结合的抗体治疗剂 |
US10618976B2 (en) | 2015-06-16 | 2020-04-14 | The Board Of Trustees Of The Leland Stanford Junior University | SIRP-α agonist antibody |
SG10201912593VA (en) | 2015-07-23 | 2020-02-27 | Boehringer Ingelheim Int | Compound targeting il-23a and b-cell activating factor (baff) and uses thereof |
MA48579A (fr) | 2015-09-01 | 2020-03-18 | Agenus Inc | Anticorps anti-pd1 et méthodes d'utilisation de ceux-ci |
CN113896790A (zh) | 2015-09-15 | 2022-01-07 | 供石公司 | 抗-原肌生长抑制素/潜伏肌生长抑制素抗体及其用途 |
SG11201804656PA (en) | 2015-12-04 | 2018-06-28 | Memorial Sloan Kettering Cancer Center | Antibodies targeting fc receptor-like 5 and methods of use |
JP7141336B2 (ja) | 2015-12-25 | 2022-09-22 | 中外製薬株式会社 | 抗ミオスタチン抗体および使用方法 |
CN115814077A (zh) | 2016-01-08 | 2023-03-21 | 供石公司 | 抗-原肌生长抑制素/潜伏肌生长抑制素抗体及其使用方法 |
MX2018009011A (es) | 2016-02-02 | 2018-11-19 | Hutchinson Fred Cancer Res | Anticuerpos anti receptor 1 transmembrana de tirosina-proteina cinasa (ror1) y usos de los mismos. |
EP3416687A4 (fr) | 2016-02-17 | 2019-10-23 | Seattle Genetics, Inc. | Anticorps bcma et leur utilisation pour traiter le cancer et les troubles immunologiques |
WO2017184973A1 (fr) * | 2016-04-22 | 2017-10-26 | University Of Tennessee Research Foundation | Identification des protéines amyloïdogènes et du risque amyloïdogène |
EP3785728A3 (fr) | 2016-06-13 | 2021-04-28 | Scholar Rock, Inc. | Utilisation d'inhibiteurs de la myostatine et thérapies combinées |
CN109996544A (zh) | 2016-06-27 | 2019-07-09 | 加利福尼亚大学董事会 | 癌症治疗组合 |
IL264161B1 (en) * | 2016-07-14 | 2025-02-01 | Scholar Rock Inc | TGFB Antibodies, Methods and Uses |
US10300145B2 (en) | 2016-07-15 | 2019-05-28 | Massachusetts Institute Of Technology | Synthetic nanoparticles for delivery of immunomodulatory compounds |
CN109689099B (zh) | 2016-08-05 | 2023-02-28 | 中外制药株式会社 | 用于预防或治疗il-8相关疾病的组合物 |
WO2018039107A1 (fr) * | 2016-08-22 | 2018-03-01 | Medimmune, Llc | Molécules de liaison spécifiques pour notch4 et leurs utilisations |
WO2018035710A1 (fr) * | 2016-08-23 | 2018-03-01 | Akeso Biopharma, Inc. | Anticorps anti-ctla4 |
MA50948A (fr) | 2016-12-07 | 2020-10-14 | Agenus Inc | Anticorps et procédés d'utilisation de ceux-ci |
RS64159B1 (sr) | 2017-01-06 | 2023-05-31 | Scholar Rock Inc | Tretiranje metaboličkih bolesti inhibiranjem aktivacije miostatina |
US11608374B2 (en) | 2017-01-30 | 2023-03-21 | Chugai Seiyaku Kabushiki Kaisha | Anti-sclerostin antibodies and methods of use |
BR112019017120A8 (pt) | 2017-02-17 | 2023-05-02 | Hutchinson Fred Cancer Res | Terapias de combinação para tratamento de cânceres e distúrbios autoimunes relacionados a bcma |
US11851486B2 (en) | 2017-05-02 | 2023-12-26 | National Center Of Neurology And Psychiatry | Method for predicting and evaluating therapeutic effect in diseases related to IL-6 and neutrophils |
DK3631454T3 (da) | 2017-05-30 | 2023-12-04 | Bristol Myers Squibb Co | Behandling af lag-3 positive tumorer |
WO2018222722A2 (fr) | 2017-05-30 | 2018-12-06 | Bristol-Myers Squibb Company | Compositions comprenant un anticorps anti-lag-3 ou un anticorps anti-lag-3 et un anticorps anti-pd-1 ou anti-pd-l1 |
WO2019079249A1 (fr) | 2017-10-16 | 2019-04-25 | Lentigen Technology, Inc. | Compositions et méthodes pour le traitement du cancer avec une immunothérapie anti-cd22 |
MX2020004243A (es) | 2017-11-01 | 2020-09-25 | Juno Therapeutics Inc | Receptores de anticuerpos y de antigenos quimericos especificos para el antigeno de maduracion de celulas b. |
CN111902159A (zh) | 2017-11-01 | 2020-11-06 | 朱诺治疗学股份有限公司 | 对b细胞成熟抗原(bcma)具有特异性的嵌合抗原受体 |
BR112020008812A2 (pt) | 2017-11-06 | 2020-10-27 | Juno Therapeutics Inc | combinação de terapia celular e um inibidor de gama secretase |
KR20200140265A (ko) | 2018-03-02 | 2020-12-15 | 엘리시오 테라퓨틱스, 인크. | Cpg 양친매성 물질 및 이의 용도 |
MA53381A (fr) * | 2018-07-24 | 2021-06-02 | Amgen Inc | Association d'inhibiteurs de la voie lilrb1/2 et d'inhibiteurs de la voie pd-1 |
MX2021005808A (es) | 2018-11-20 | 2021-07-02 | Univ Cornell | Complejos macrociclicos de radionucleidos alfa-emisores y su uso en radioterapia focalizada de cancer. |
KR20220002891A (ko) | 2019-03-15 | 2022-01-07 | 모르포시스 아게 | 자가항체-매개 자가면역 질병의 치료를 위한 항-cd38 항체 및 이의 약제학적 조성물 |
AU2021253821A1 (en) * | 2020-04-08 | 2022-11-24 | Aliada Therapeutics, Inc. | Anti-CD98 antibodies and uses thereof |
US20230212266A1 (en) * | 2020-04-27 | 2023-07-06 | Fred Hutchinson Cancer Center | Neutralizing monoclonal antibodies against covid19 |
IL297981A (en) | 2020-05-08 | 2023-01-01 | Alpine Immune Sciences Inc | Immunomodulatory proteins that inhibit april and baff together with and without a t-cell suppressor protein and methods of using them |
WO2022132887A1 (fr) * | 2020-12-15 | 2022-06-23 | Board Of Regents, The University Of Texas System | Anticorps monoclonaux humains ciblant la protéine de spicule du sars-cov-2 |
BR112023022133A2 (pt) | 2021-05-07 | 2023-12-26 | Viela Bio Inc | Uso de um anticorpo anti-cd19 para tratar miastenia gravis |
KR20240038773A (ko) | 2021-07-27 | 2024-03-25 | 아스트라제네카 아베 | 루푸스의 치료 |
CN117003872A (zh) * | 2022-04-28 | 2023-11-07 | 北京天广实生物技术股份有限公司 | 含有突变轻链可变区骨架的单链抗体片段 |
TW202404639A (zh) * | 2022-07-19 | 2024-02-01 | 瑞士商諾華公司 | Aiha之治療 |
Family Cites Families (244)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US4444887A (en) | 1979-12-10 | 1984-04-24 | Sloan-Kettering Institute | Process for making human antibody producing B-lymphocytes |
US4474893A (en) | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
US4714681A (en) | 1981-07-01 | 1987-12-22 | The Board Of Reagents, The University Of Texas System Cancer Center | Quadroma cells and trioma cells and methods for the production of same |
US4716111A (en) | 1982-08-11 | 1987-12-29 | Trustees Of Boston University | Process for producing human antibodies |
US4741900A (en) | 1982-11-16 | 1988-05-03 | Cytogen Corporation | Antibody-metal ion complexes |
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
EP0173494A3 (fr) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Récepteurs chimériques par liaison et expression de l'ADN |
US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
US4631211A (en) | 1985-03-25 | 1986-12-23 | Scripps Clinic & Research Foundation | Means for sequential solid phase organic synthesis and methods using the same |
JP2532858B2 (ja) | 1985-04-01 | 1996-09-11 | セルテツク リミテツド | 形質転換したミエロ―マ細胞系 |
US4980286A (en) | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
US5576195A (en) * | 1985-11-01 | 1996-11-19 | Xoma Corporation | Vectors with pectate lyase signal sequence |
EP0247091B1 (fr) | 1985-11-01 | 1993-09-29 | Xoma Corporation | Assemblage modulaire de genes d'anticorps, anticorps ainsi prepares et utilisation |
GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
AU600575B2 (en) | 1987-03-18 | 1990-08-16 | Sb2, Inc. | Altered antibodies |
US5489425A (en) | 1987-06-24 | 1996-02-06 | The Dow Chemical Company | Functionalized polyamine chelants |
US4994560A (en) | 1987-06-24 | 1991-02-19 | The Dow Chemical Company | Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies |
GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
US5336603A (en) | 1987-10-02 | 1994-08-09 | Genentech, Inc. | CD4 adheson variants |
GB8725529D0 (en) | 1987-10-30 | 1987-12-02 | Delta Biotechnology Ltd | Polypeptides |
EP0428534B1 (fr) | 1988-06-14 | 1995-03-29 | Cetus Oncology Corporation | Agents de couplage et conjugues lies a des disulfures a empechement sterique prepares a partir de tels agents |
NZ229700A (en) | 1988-06-24 | 1993-01-27 | Dow Chemical Co | Tetraazacyclododecane derivatives containing a linker/spacer moiety capable of forming antibody conjugates; complexes with radionuclides and conjugates of such compounds and complexes with antibodies or antibody fragments |
CN1033030C (zh) | 1988-06-24 | 1996-10-16 | 唐化学原料公司 | 大环双官能螯合剂及其配合物和抗体共轭物的制备方法 |
US5756065A (en) | 1988-06-24 | 1998-05-26 | The Dow Chemical Company | Macrocyclic tetraazacyclododecane conjugates and their use as diagnostic and therapeutic agents |
US5274119A (en) | 1988-07-01 | 1993-12-28 | The Dow Chemical Company | Vicinal diols |
US4925648A (en) | 1988-07-29 | 1990-05-15 | Immunomedics, Inc. | Detection and treatment of infectious and inflammatory lesions |
US5601819A (en) | 1988-08-11 | 1997-02-11 | The General Hospital Corporation | Bispecific antibodies for selective immune regulation and for selective immune cell binding |
AU4308689A (en) | 1988-09-02 | 1990-04-02 | Protein Engineering Corporation | Generation and selection of recombinant varied binding proteins |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5696239A (en) | 1988-10-31 | 1997-12-09 | The Dow Chemical Company | Conjugates possessing ortho ligating functionality and complexes thereof |
KR900005995A (ko) | 1988-10-31 | 1990-05-07 | 우메모또 요시마사 | 변형 인터류킨-2 및 그의 제조방법 |
US5342604A (en) | 1988-10-31 | 1994-08-30 | The Dow Chemical Company | Complexes possessing ortho ligating functionality |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
EP0394827A1 (fr) | 1989-04-26 | 1990-10-31 | F. Hoffmann-La Roche Ag | Polypeptides chimériques de CD4-immunoglobuline |
US5766883A (en) | 1989-04-29 | 1998-06-16 | Delta Biotechnology Limited | Polypeptides |
IE63847B1 (en) | 1989-05-05 | 1995-06-14 | Res Dev Foundation | A novel antibody delivery system for biological response modifiers |
US6291161B1 (en) * | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertiore |
US5808003A (en) | 1989-05-26 | 1998-09-15 | Perimmune Holdings, Inc. | Polyaminocarboxylate chelators |
CA2062795A1 (fr) | 1989-06-29 | 1990-12-30 | Michael W. Fanger | Reactifs bispecifiques pour le traitement du sida |
US6020145A (en) | 1989-06-30 | 2000-02-01 | Bristol-Myers Squibb Company | Methods for determining the presence of carcinoma using the antigen binding region of monoclonal antibody BR96 |
US5112946A (en) | 1989-07-06 | 1992-05-12 | Repligen Corporation | Modified pf4 compositions and methods of use |
US5413923A (en) | 1989-07-25 | 1995-05-09 | Cell Genesys, Inc. | Homologous recombination for universal donor cells and chimeric mammalian hosts |
FR2650598B1 (fr) | 1989-08-03 | 1994-06-03 | Rhone Poulenc Sante | Derives de l'albumine a fonction therapeutique |
US5073627A (en) | 1989-08-22 | 1991-12-17 | Immunex Corporation | Fusion proteins comprising GM-CSF and IL-3 |
US5436146A (en) | 1989-09-07 | 1995-07-25 | The Trustees Of Princeton University | Helper-free stocks of recombinant adeno-associated virus vectors |
GB8923843D0 (en) * | 1989-10-23 | 1989-12-13 | Salutar Inc | Compounds |
WO1991006570A1 (fr) | 1989-10-25 | 1991-05-16 | The University Of Melbourne | MOLECULES RECEPTRICES Fc HYBRIDES |
GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
US5780225A (en) | 1990-01-12 | 1998-07-14 | Stratagene | Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules |
AU7247191A (en) | 1990-01-11 | 1991-08-05 | Molecular Affinities Corporation | Production of antibodies using gene libraries |
WO1991010741A1 (fr) | 1990-01-12 | 1991-07-25 | Cell Genesys, Inc. | Generation d'anticorps xenogeniques |
US5314995A (en) | 1990-01-22 | 1994-05-24 | Oncogen | Therapeutic interleukin-2-antibody based fusion proteins |
WO1991014438A1 (fr) | 1990-03-20 | 1991-10-03 | The Trustees Of Columbia University In The City Of New York | Anticorps chimeriques utilisant des ligands de liaison de recepteurs a la place de leur region constante |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
US5349053A (en) | 1990-06-01 | 1994-09-20 | Protein Design Labs, Inc. | Chimeric ligand/immunoglobulin molecules and their uses |
US5635384A (en) * | 1990-06-11 | 1997-06-03 | Dowelanco | Ribosome-inactivating proteins, inactive precursor forms thereof, a process for making and a method of using |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
EP0814159B1 (fr) | 1990-08-29 | 2005-07-27 | GenPharm International, Inc. | Souris transgéniques capables de produire des anticorps hétérologues |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5698426A (en) | 1990-09-28 | 1997-12-16 | Ixsys, Incorporated | Surface expression libraries of heteromeric receptors |
AU660629B2 (en) | 1990-10-01 | 1995-07-06 | University Of Connecticut, The | Targeting viruses and cells for selective internalization by cells |
JP3583420B2 (ja) | 1990-10-05 | 2004-11-04 | メダレツクス・インコーポレーテツド | 二特異的試薬を用いた標的免疫化 |
EP0557300B1 (fr) | 1990-10-29 | 1997-11-19 | Chiron Corporation | Anticorps bispecifiques, methodes de production et utilisation desdits anticorps |
EP0574395B1 (fr) | 1990-11-09 | 2002-06-12 | GILLIES, Stephen D. | Immunoconjugues de cytokine |
ATE164395T1 (de) | 1990-12-03 | 1998-04-15 | Genentech Inc | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
DK0517895T3 (da) | 1990-12-14 | 1997-04-07 | Univ California | Kimæriske kæder til receptorforbundne signaltransduktionsveje |
DK0577752T4 (da) | 1991-03-29 | 2007-10-22 | Genentech Inc | Human PF4A receptorer og deres anvendelse |
DE69233367T2 (de) | 1991-04-10 | 2005-05-25 | The Scripps Research Institute, La Jolla | Bibliotheken heterodimerer rezeptoren mittels phagemiden |
JP3431140B2 (ja) | 1991-04-26 | 2003-07-28 | サーフィス・アクティブ・リミテッド | 抗体およびその使用方法 |
DK0584279T3 (da) | 1991-05-14 | 2001-06-11 | Immune Response Corp Inc | Målrettet aflevering af gener, som koder for immunogene proteiner |
DE69233482T2 (de) | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen |
ATE195656T1 (de) | 1991-06-05 | 2000-09-15 | Univ Connecticut | Zielgerichtete freisetzung von genen, die sekretorische proteine kodieren |
EP0590067A1 (fr) | 1991-06-14 | 1994-04-06 | Xoma Corporation | Fragments d'anticorps produits par des microbes et leurs conjugues |
IL99120A0 (en) | 1991-08-07 | 1992-07-15 | Yeda Res & Dev | Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them |
US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
US5376546A (en) | 1991-11-04 | 1994-12-27 | Xoma Corporation | Analogs of ribosome-inactivating proteins |
DE69233782D1 (de) | 1991-12-02 | 2010-05-20 | Medical Res Council | Herstellung von Autoantikörpern auf Phagenoberflächen ausgehend von Antikörpersegmentbibliotheken |
US5428139A (en) | 1991-12-10 | 1995-06-27 | The Dow Chemical Company | Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals |
AU3434393A (en) | 1992-01-17 | 1993-08-03 | Regents Of The University Of Michigan, The | Targeted virus |
US5622929A (en) | 1992-01-23 | 1997-04-22 | Bristol-Myers Squibb Company | Thioether conjugates |
FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
ATE239506T1 (de) | 1992-03-05 | 2003-05-15 | Univ Texas | Verwendung von immunokonjugate zur diagnose und/oder therapie der vaskularisierten tumoren |
US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
US5447851B1 (en) | 1992-04-02 | 1999-07-06 | Univ Texas System Board Of | Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells |
WO1993020221A1 (fr) | 1992-04-03 | 1993-10-14 | Young Alexander T | Therapie genique utilisant des vecteurs viraux cibles |
ZA932522B (en) | 1992-04-10 | 1993-12-20 | Res Dev Foundation | Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens |
DE69325777T2 (de) | 1992-06-09 | 2000-03-09 | Hoppe Ag | Riegel und türschloss |
US5962301A (en) | 1992-06-12 | 1999-10-05 | Massachusetts Institute Of Technology | Relatedness of human interleukin-1β convertase gene to a C. elegans cell death gene, inhibitory portions of these genes and uses therefor |
US5505931A (en) | 1993-03-04 | 1996-04-09 | The Dow Chemical Company | Acid cleavable compounds, their preparation and use as bifunctional acid-labile crosslinking agents |
EP0749475A4 (fr) | 1992-08-26 | 1997-05-07 | Harvard College | Utilisation de la cytokine ip-10 comme agent antitumeur |
US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
US5605671A (en) * | 1992-10-05 | 1997-02-25 | The Regents Of The University Of Michigan | Radiolabeled neutrophil activating peptides for imaging |
AU689758B2 (en) | 1992-10-09 | 1998-04-09 | Advanced Tissue Sciences, Inc. | Liver reserve cells |
US5869331A (en) | 1992-11-20 | 1999-02-09 | University Of Medicine & Dentistry Of New Jersey | Cell type specific gene transfer using retroviral vectors containing antibody-envelope fusion proteins and wild-type envelope fusion proteins |
US5589499A (en) | 1992-11-25 | 1996-12-31 | Weth; Gosbert | Dopaminergic agents for the treatment of cerebral and peripheral blood flow disorders |
EP0905253A3 (fr) | 1992-12-03 | 2000-11-02 | Genzyme Corporation | Vecteur adenovira délété de tous les ORF de E4 excepté ORF6 |
US5441050A (en) | 1992-12-18 | 1995-08-15 | Neoprobe Corporation | Radiation responsive surgical instrument |
EP0652231A1 (fr) | 1993-03-02 | 1995-05-10 | Universidad De Valladolid | PROTEINES INACTIVATRICES DE RIBOSOMES (RIPs) A DEUX CHAINES NON TOXIQUES, PROCEDE POUR LEUR PREPARATION ET APPLICATIONS |
DE69415026D1 (de) | 1993-09-06 | 1999-01-14 | Menarini Richerche Sud S P A | Ribosom-inaktievirende proteine, die aus saponaria ocymoides und vaccaria pyramidata samen extrahiert sind sowie deren herstellung und immunotoxine, die sie enthalten |
US5595721A (en) * | 1993-09-16 | 1997-01-21 | Coulter Pharmaceutical, Inc. | Radioimmunotherapy of lymphoma using anti-CD20 |
US5643575A (en) * | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
AU696293B2 (en) | 1993-12-08 | 1998-09-03 | Genzyme Corporation | Process for generating specific antibodies |
US5597709A (en) | 1994-01-27 | 1997-01-28 | Human Genome Sciences, Inc. | Human growth hormone splice variants hGHV-2(88) and hGHV-3(53) |
DK1231268T3 (da) | 1994-01-31 | 2005-11-21 | Univ Boston | Polyklonale antistofbiblioteker |
US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
US5834252A (en) | 1995-04-18 | 1998-11-10 | Glaxo Group Limited | End-complementary polymerase reaction |
US5605793A (en) * | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
US5817485A (en) | 1994-03-08 | 1998-10-06 | Human Genome Sciences, Inc. | Nucleic acids and cells for recombinant production of fibroblast growth factor-10 |
US5633147A (en) | 1994-03-08 | 1997-05-27 | Human Genome Sciences, Inc. | Transforming growth factor αH1 |
AU7394294A (en) | 1994-05-16 | 1995-12-05 | Human Genome Sciences, Inc. | Macrophage migration inhibitory factor-3 |
US5516637A (en) | 1994-06-10 | 1996-05-14 | Dade International Inc. | Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage |
US5985660A (en) | 1994-06-15 | 1999-11-16 | Systemix, Inc. | Method of identifying biological response modifiers involved in dendritic and/or lymphoid progenitor cell proliferation and/or differentiation |
BR9508469A (pt) | 1994-07-29 | 1997-09-16 | Smithkline Beecham Plc | Proteína solúvel tendo antagonista il4 e/ou il13 ou atividade antagonista parcial composto processo para a preparação do mesmo polímero de DNA vetor de exemplo replicável célula hospedeira composição farmacêutica processo para tratar condições e uso do composto |
EP0792278B1 (fr) | 1994-11-07 | 2007-06-13 | Human Genome Sciences, Inc. | Polypeptide gamma appartenant a la famille des facteurs de necrose tumorale (fnt) |
US6030613A (en) | 1995-01-17 | 2000-02-29 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of therapeutics |
WO1996022024A1 (fr) | 1995-01-17 | 1996-07-25 | Brigham And Women's Hospital, Inc. | Transport transepithelial specifique de recepteurs d'immunogenes |
AU2363695A (en) | 1995-04-27 | 1996-11-18 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptors |
CA2761116A1 (fr) | 1995-04-27 | 1996-10-31 | Amgen Fremont Inc. | Anticorps humains derives d'une xenosouris immunisee |
CA2219486A1 (fr) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Anticorps humains derives de xeno-souris immunisees |
US5874409A (en) | 1995-06-07 | 1999-02-23 | La Jolla Pharmaceutical Company | APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies |
GB9601081D0 (en) | 1995-10-06 | 1996-03-20 | Cambridge Antibody Tech | Specific binding members for human transforming growth factor beta;materials and methods |
JP2978435B2 (ja) | 1996-01-24 | 1999-11-15 | チッソ株式会社 | アクリロキシプロピルシランの製造方法 |
US6635492B2 (en) | 1996-01-25 | 2003-10-21 | Bjs Company Ltd. | Heating specimen carriers |
WO1997033904A1 (fr) | 1996-03-12 | 1997-09-18 | Human Genome Sciences, Inc. | Recepteurs contenant un domaine de mort cellulaire |
WO1997033899A1 (fr) | 1996-03-14 | 1997-09-18 | Human Genome Sciences, Inc. | Molecule i induisant l'apoptose |
ATE254135T1 (de) | 1996-03-14 | 2003-11-15 | Human Genome Sciences Inc | Humaner tumornekrosefaktor delta und epsilon |
US6541224B2 (en) * | 1996-03-14 | 2003-04-01 | Human Genome Sciences, Inc. | Tumor necrosis factor delta polypeptides |
KR20030096450A (ko) | 1996-03-22 | 2003-12-31 | 휴먼 게놈 사이언시즈, 인코포레이티드 | 고사 유도 분자 ⅱ |
US5792850A (en) | 1996-05-23 | 1998-08-11 | Zymogenetics, Inc. | Hematopoietic cytokine receptor |
US6300065B1 (en) * | 1996-05-31 | 2001-10-09 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
AU734638B2 (en) | 1996-06-06 | 2001-06-21 | Lajolla Pharmaceutical Company | aPL immunoreactive peptides, conjugates thereof and methods of treatment for aPL antibody-mediated pathologies |
IT1286663B1 (it) | 1996-06-27 | 1998-07-15 | Ministero Uni Ricerca Scient E | Proteina capace di inibire l'attivita' ribosomiale,sua preparazione ed uso come immunoconiugato chimico o ricombinante e sequenza di cdna |
CA2263129C (fr) | 1996-08-16 | 2007-01-09 | Schering Corporation | Antigenes de surface de cellules mammaliennes et reactifs qui y sont lies |
NZ334035A (en) | 1996-08-16 | 2000-09-29 | Human Genome Sciences Inc | Use of endokine alpha antagonists to diagnose and treat TNF-related disorders |
US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
US20020115112A1 (en) * | 1999-02-23 | 2002-08-22 | Human Genome Sciences, Inc. | Neutrokine-alpha and Neutrokine-alpha splice variant |
WO1998018921A1 (fr) | 1996-10-25 | 1998-05-07 | Human Genome Sciences, Inc. | Neutrokine alpha |
US6689579B1 (en) * | 1996-10-25 | 2004-02-10 | Human Genome Sciences, Inc. | Polynucleotides encoding neutrokine-α |
US20030175208A1 (en) * | 1996-10-25 | 2003-09-18 | Human Genome Sciences, Inc. | Neutrokine-alpha and neutrokine-alpha splice variant |
US6812327B1 (en) | 1996-10-25 | 2004-11-02 | Human Genome Sciences, Inc. | Neutrokine-alpha polypeptides |
US8212004B2 (en) * | 1999-03-02 | 2012-07-03 | Human Genome Sciences, Inc. | Neutrokine-alpha fusion proteins |
WO1999035170A2 (fr) | 1998-01-05 | 1999-07-15 | Genentech, Inc. | Compositions et methodes pour le traitement des tumeurs |
EP2305027B1 (fr) | 1996-12-03 | 2014-07-02 | Amgen Fremont Inc. | Mammifères trangèniques obtenus par génie génétique contenant des loci des immunoglobulines humaines qui comprennent plusieurs régions de VH et de Vkappa, et anticorps aussi obtenus. |
AU5705898A (en) | 1996-12-17 | 1998-07-15 | Schering Corporation | Mammalian cell surface antigens; related reagents |
AU6238698A (en) | 1997-01-14 | 1998-08-03 | Human Genome Sciences, Inc. | Tumor necrosis factor receptor 5 |
ES2286843T3 (es) | 1997-01-14 | 2007-12-01 | Human Genome Sciences, Inc. | Receptores 6 alfa y 6 beta del factor de necrosis tumoral. |
DK1012274T4 (da) | 1997-01-28 | 2011-07-25 | Human Genome Sciences Inc | Dødsdomæneholdig receptor-4 (DR4: dødsreceptor 4), medlem af TNF-receptorsuperfamilien og som binder til TRAIL (Apo-2L) |
US5969102A (en) | 1997-03-03 | 1999-10-19 | St. Jude Children's Research Hospital | Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof |
NZ337795A (en) | 1997-03-17 | 2001-06-29 | Human Genome Sciences Inc | Death domain containing receptor 5 and it's use in the treatment of DR5 related disease |
CA2232743A1 (fr) | 1997-04-02 | 1998-10-02 | Smithkline Beecham Corporation | Tl5, homologue tnf |
TR199902553T2 (xx) | 1997-04-14 | 2000-03-21 | Micromet Gesellschaft F�R Biomedizinische Forschung Mbh | �nsan v�cuduna kar�� antijen resept�rlerinin �retimi i�in yeni metod ve kullan�mlar�. |
JP2002514079A (ja) | 1997-05-01 | 2002-05-14 | アムジエン・インコーポレーテツド | キメラopgポリペプチド |
US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
DK1798288T3 (da) | 1997-05-07 | 2010-01-04 | Schering Corp | Humane Toll-lignende receptorproteiner, relaterede reagenser og fremgangsmåder |
WO1998054202A1 (fr) | 1997-05-30 | 1998-12-03 | Human Genome Sciences, Inc. | Recepteur tr10 du facteur de necrose tumorale humain |
JP2002504818A (ja) | 1997-06-06 | 2002-02-12 | リジェネロン ファーマシューティカルズ,インコーポレイテッド | リガンドファミリーのntn−2メンバー |
AU7608898A (en) | 1997-06-06 | 1998-12-21 | Regeneron Pharmaceuticals, Inc. | Ntn-2 member of tnf ligand family |
EP0975762B1 (fr) | 1997-06-06 | 2011-10-05 | PanGenetics B.V. | Proteine de type 1 inactivant un ribosome |
WO1998056892A1 (fr) | 1997-06-11 | 1998-12-17 | Human Genome Sciences, Inc. | Recepteur humain tr9 du facteur de necrose tumorale |
US5948619A (en) | 1997-07-31 | 1999-09-07 | Incyte Pharmaceuticals, Inc. | Human zygin-1 |
US6342220B1 (en) * | 1997-08-25 | 2002-01-29 | Genentech, Inc. | Agonist antibodies |
WO1999011791A2 (fr) | 1997-09-05 | 1999-03-11 | University Of Washington | Recepteurs et ligands de la famille du facteur de necrose tumorale, acides nucleiques codants et agents de liaison associes |
TR200000654T2 (tr) | 1997-09-12 | 2000-07-21 | Apotech R & D Sa | KAY-Yeni bir bağışıklık sistemi proteini. |
US5795724A (en) * | 1997-09-12 | 1998-08-18 | Incyte Pharmaceuticals, Inc. | Human N-acetyl transferase |
MXPA00004256A (es) | 1997-11-03 | 2005-07-01 | Human Genome Sciences Inc | Inhibidor de las celulas endoteliales vasculares, un inhibidor de la angiogenesis y crecimiento del tumor. |
US20020055624A1 (en) * | 1997-11-17 | 2002-05-09 | Steven R. Wiley | Tnf-delta ligand and uses thereof |
US20010010925A1 (en) * | 1997-11-17 | 2001-08-02 | Steven R. Wiley | Methods of detecting target nucleic acids of tnf-delta |
JP2002503444A (ja) | 1997-11-26 | 2002-02-05 | イーライ・リリー・アンド・カンパニー | リガンドファミリー遺伝子 |
WO1999033980A2 (fr) | 1997-12-30 | 1999-07-08 | Chiron Corporation | Membres de familles de tnf et de tnfr |
US6297367B1 (en) | 1997-12-30 | 2001-10-02 | Chiron Corporation | Polynucleotide encoding TNFL1 |
WO1999046295A1 (fr) | 1998-03-12 | 1999-09-16 | Shanghai Second Medical University | Gene homologue au gene b(2)gene de drosophile et proteine ypr015c de levure putative 26,5kd |
WO1999047538A1 (fr) | 1998-03-19 | 1999-09-23 | Human Genome Sciences, Inc. | Analogue de chaine gamma commune de recepteur de cytokine |
CA2294364A1 (fr) | 1998-04-20 | 1999-10-28 | Lss Life Support Systems Ag | Tenue vestimentaire de protection contre les effets de l'acceleration |
EP1076703B2 (fr) | 1998-05-15 | 2010-12-15 | Genentech, Inc. | Utilisations therapeutiques de polypeptides homologues de il-17 |
WO2000026244A2 (fr) | 1998-11-04 | 2000-05-11 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Nouveau membre de la famille des facteurs de necrose des tumeurs, ligand du recepteur de la mort cellulaire (drl) et compositions et procedes correspondants |
GB9828628D0 (en) | 1998-12-23 | 1999-02-17 | Glaxo Group Ltd | Novel ligand |
US6297637B1 (en) * | 1998-12-29 | 2001-10-02 | Siemens Aktiengesellschaft | High-frequency receiver, particularly for a nuclear magnetic resonance apparatus |
DE60043626D1 (de) | 1999-01-07 | 2010-02-11 | Zymogenetics Inc | Verfahren zur therapeutischen Verwendung von löslichen rezeptoren BR43X2 |
NZ513284A (en) * | 1999-01-25 | 2003-10-31 | Biogen Inc | BAFF blocking agents and their use in the stimulation and inhibition of B-cells and immunoglobulins in immune responses |
US20030095967A1 (en) | 1999-01-25 | 2003-05-22 | Mackay Fabienne | BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders |
US20050100548A1 (en) | 2001-07-24 | 2005-05-12 | Biogen Idec Ma Inc. | BAFF, inhibitors thereof and their use in the modulation of B-cell response |
US6475986B1 (en) | 1999-02-02 | 2002-11-05 | Research Development Foundation | Uses of THANK, a TNF homologue that activates apoptosis |
AU2880400A (en) | 1999-02-12 | 2000-08-29 | Amgen, Inc. | Tnf-related proteins |
NZ513290A (en) | 1999-02-23 | 2004-05-28 | Human Genome Sciences Inc | Neutrokine-alpha and neutrokine-alpha splice variant |
WO2000058362A1 (fr) | 1999-03-26 | 2000-10-05 | Human Genome Sciences, Inc. | Nouvelles proteines capables de liaison avec la neutrokine alpha et procedes bases sur lesdites proteines |
US20030022233A1 (en) * | 1999-04-30 | 2003-01-30 | Raymond G. Goodwin | Methods of use of the taci/taci-l interaction |
AU4986700A (en) * | 1999-05-06 | 2000-11-21 | National Jewish Medical And Research Center | Tall-1 nucleic acid molecules, proteins, receptors and methods of use thereof |
AU5308200A (en) | 1999-06-11 | 2001-01-02 | Human Genome Sciences, Inc. | 48 human secreted proteins |
NZ517782A (en) | 1999-08-17 | 2004-01-30 | Biogen Inc | A beta-cell activating factor receptor belonging to the TNF family is used as a pharmaceutical agent and in the treatment of disease |
UA74798C2 (uk) | 1999-10-06 | 2006-02-15 | Байоджен Айдек Ма Інк. | Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами |
EP1669371A3 (fr) | 1999-12-01 | 2006-06-21 | Genentech, Inc. | Composition et procédés de diagnostic de tumeurs |
AU2001234953B2 (en) * | 2000-02-11 | 2006-03-16 | Biogen Ma Inc. | Heterologous polypeptide of the tnf family |
IL150755A0 (en) | 2000-02-16 | 2003-02-12 | Genentech Inc | Uses of agonists and antagonists to modulate activity of tnf-related molecules |
ES2271004T3 (es) | 2000-04-27 | 2007-04-16 | Biogen Idec Ma Inc. | Uso de taci como agente antitumoral. |
ES2287130T3 (es) * | 2000-05-12 | 2007-12-16 | Amgen Inc. | Polipeptidos para inhibir la proliferacion de celulas b y t inducida por april. |
CA2413160A1 (fr) | 2000-06-15 | 2001-12-20 | Human Genome Sciences, Inc. | Facteur de necrose tumorale humain delta et epsilon |
US7879328B2 (en) | 2000-06-16 | 2011-02-01 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to B lymphocyte stimulator |
US7220840B2 (en) * | 2000-06-16 | 2007-05-22 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to B lymphocyte stimulator protein |
CA2407910C (fr) * | 2000-06-16 | 2013-03-12 | Steven M. Ruben | Anticorps se liant de maniere immunospecifique a un stimulateur de lymphocyte b |
JP2004512262A (ja) * | 2000-06-20 | 2004-04-22 | アイデック ファーマスーティカルズ コーポレイション | 非放射性抗cd20抗体/放射標識抗cd22抗体の組合せ |
EP1309718A4 (fr) | 2000-08-15 | 2004-08-25 | Human Genome Sciences Inc | Neutrokine-alpha et variant d'epissage de neutrokine-alpha |
WO2002016411A2 (fr) | 2000-08-18 | 2002-02-28 | Human Genome Sciences, Inc. | Polypeptides de fixation et procedes associes |
EP2267016A3 (fr) * | 2000-08-18 | 2011-04-20 | Human Genome Sciences, Inc. | Polypeptides de liaison pour la protéine stimulatrice des lymphocytes B (BLyS) |
UA83458C2 (uk) | 2000-09-18 | 2008-07-25 | Байоджен Айдек Ма Інк. | Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf) |
US20030092164A1 (en) | 2000-11-07 | 2003-05-15 | Gross Jane A. | Human tumor necrosis factor receptor |
EP1362061A2 (fr) | 2001-02-20 | 2003-11-19 | ZymoGenetics, Inc. | Anticorps liant a la fois bcma et taci |
DK1385882T3 (da) * | 2001-05-11 | 2008-02-11 | Amgen Inc | Peptider og relaterede molekyler, der binder til TALL-1 |
CN1612750B (zh) | 2001-05-24 | 2012-10-31 | 津莫吉尼蒂克斯公司 | Taci-免疫球蛋白融合蛋白质 |
AR035119A1 (es) | 2001-08-16 | 2004-04-14 | Lilly Co Eli | Anticuerpos humanos antagonistas anti-htnfsf13b |
JP4002082B2 (ja) | 2001-09-14 | 2007-10-31 | 古河電気工業株式会社 | 光ファイバ母材およびその製造方法 |
US7521053B2 (en) | 2001-10-11 | 2009-04-21 | Amgen Inc. | Angiopoietin-2 specific binding agents |
WO2003033658A2 (fr) | 2001-10-17 | 2003-04-24 | Human Genome Sciences, Inc. | Neutrokine-alpha et variant d'epissage de neutrokine-alpha |
US20050054567A1 (en) | 2001-11-06 | 2005-03-10 | Rowlinson Scott William | Use of il-19,il-22 and il-24 to treat hematopoietic disorders |
WO2003055979A2 (fr) | 2001-11-16 | 2003-07-10 | Human Genome Sciences, Inc. | Anticorps se liant à blys selon un mode immunospécifique |
US20020150579A1 (en) * | 2002-01-10 | 2002-10-17 | Kimberly Robert P. | B lymphocyte stimulator (BLyS) as a marker in management of systemic lupus erythematosus |
WO2003072713A2 (fr) | 2002-02-21 | 2003-09-04 | Biogen Idec Ma Inc. | Utilisation de bcma comme agent immunoregulateur |
AU2003299819A1 (en) | 2002-12-23 | 2004-07-22 | Human Genome Sciences, Inc. | Neutrokine-alpha conjugate, neutrokine-alpha complex, and uses thereof |
WO2004074511A1 (fr) | 2003-02-21 | 2004-09-02 | Garvan Institute Of Medical Research | Diagnostic et traitement des maladies auto-immunes mediees par baff et du cancer |
US20050163775A1 (en) | 2003-06-05 | 2005-07-28 | Genentech, Inc. | Combination therapy for B cell disorders |
NZ543712A (en) | 2003-06-05 | 2008-06-30 | Genentech Inc | Combination therapy for B cell disorders |
RU2006117324A (ru) | 2003-10-20 | 2007-12-10 | Байоджен Айдек Ма Инк. (Us) | Терапевтические режимы для антагонистов baff |
DE10355251A1 (de) | 2003-11-26 | 2005-06-23 | Merck Patent Gmbh | Pharmazeutische Zubereitung enthaltend einen Antikörper gegen den EGF-Rezeptor |
NZ560285A (en) | 2005-01-28 | 2011-04-29 | Biogen Idec Inc | Use of baff to treat Th2-mediated conditions |
US20060171919A1 (en) * | 2005-02-01 | 2006-08-03 | Research Development Foundation | Targeted polypeptides |
US20090215071A1 (en) | 2005-07-28 | 2009-08-27 | Teresa Cachero | Methods of targeting baff |
NZ597082A (en) | 2005-10-13 | 2013-11-29 | Human Genome Sciences Inc | Methods and Compositions for Use in Treatment of Patients with Autoantibody Positive Diseases |
US9168286B2 (en) | 2005-10-13 | 2015-10-27 | Human Genome Sciences, Inc. | Methods and compositions for use in treatment of patients with autoantibody positive disease |
AU2006318539B2 (en) | 2005-11-23 | 2012-09-13 | Genentech, Inc. | Methods and compositions related to B cell assays |
WO2007123765A2 (fr) | 2006-03-31 | 2007-11-01 | Human Genome Sciences Inc. | NEUTROKINE-ALPHA et variant d'epissage de la neutrokine-alpha |
RS52888B (en) | 2007-03-27 | 2014-02-28 | Zymogenetics Inc. | COMBINATION OF BLYS INHIBITION AND MYPHOPHENOLATE MOFETILE FOR THE TREATMENT OF AUTOMMUNE DISEASE |
AU2009239437B2 (en) | 2008-04-25 | 2014-11-13 | University Of Washington | Levels of BCMA protein expression on B cells and use in diagnostic methods |
WO2010093993A2 (fr) * | 2009-02-12 | 2010-08-19 | Human Genome Sciences, Inc. | Utilisation d'antagonistes de la protéine stimulant les lymphocytes b afin de favoriser la tolérance aux greffes |
WO2011160086A2 (fr) | 2010-06-18 | 2011-12-22 | Human Genome Sciences, Inc. | Utilisation d'antagonistes d'une protéine stimulant les lymphocytes b en vue du traitement de l'asthme et d'autres affections allergiques et inflammatoires du système respiratoire |
-
2001
- 2001-06-15 CA CA2407910A patent/CA2407910C/fr not_active Expired - Lifetime
- 2001-06-15 ES ES01946365T patent/ES2358885T3/es not_active Expired - Lifetime
- 2001-06-15 PT PT101851780T patent/PT2275449T/pt unknown
- 2001-06-15 EP EP10185182A patent/EP2281842A1/fr not_active Ceased
- 2001-06-15 KR KR1020107026974A patent/KR101287395B1/ko active IP Right Grant
- 2001-06-15 US US09/880,748 patent/US7138501B2/en not_active Expired - Lifetime
- 2001-06-15 KR KR1020027017188A patent/KR101155294B1/ko active Protection Beyond IP Right Term
- 2001-06-15 KR KR1020067011863A patent/KR20060088905A/ko not_active Application Discontinuation
- 2001-06-15 WO PCT/US2001/019110 patent/WO2002002641A1/fr active IP Right Grant
- 2001-06-15 DK DK01946365.2T patent/DK1294769T3/da active
- 2001-06-15 DE DE60143798T patent/DE60143798D1/de not_active Expired - Lifetime
- 2001-06-15 NZ NZ522700A patent/NZ522700A/en not_active IP Right Cessation
- 2001-06-15 AT AT01946365T patent/ATE494304T1/de active
- 2001-06-15 ES ES10185185.5T patent/ES2609583T3/es not_active Expired - Lifetime
- 2001-06-15 JP JP2002507892A patent/JP4902087B2/ja not_active Expired - Lifetime
- 2001-06-15 EP EP10185185.5A patent/EP2281843B1/fr not_active Expired - Lifetime
- 2001-06-15 ES ES10185178.0T patent/ES2609016T3/es not_active Expired - Lifetime
- 2001-06-15 EP EP01946365A patent/EP1294769B1/fr not_active Expired - Lifetime
- 2001-06-15 EP EP10185178.0A patent/EP2275449B1/fr not_active Expired - Lifetime
- 2001-06-15 MX MXPA02012434A patent/MXPA02012434A/es active IP Right Grant
- 2001-06-15 AU AU6842701A patent/AU6842701A/xx active Pending
- 2001-06-15 PT PT101851855T patent/PT2281843T/pt unknown
- 2001-06-15 CN CNB01811296XA patent/CN1279055C/zh not_active Expired - Lifetime
- 2001-06-15 KR KR1020127008774A patent/KR20120053525A/ko not_active Application Discontinuation
- 2001-06-15 AU AU2001268427A patent/AU2001268427B2/en active Active
-
2003
- 2003-06-03 HK HK03103931.3A patent/HK1051697A1/xx not_active IP Right Cessation
-
2005
- 2005-11-04 US US11/266,444 patent/US7605236B2/en not_active Expired - Lifetime
-
2008
- 2008-10-02 JP JP2008257439A patent/JP4902618B2/ja not_active Expired - Lifetime
-
2009
- 2009-03-09 AU AU2009200977A patent/AU2009200977B2/en not_active Expired
- 2009-09-02 US US12/552,915 patent/US8101181B2/en not_active Expired - Fee Related
-
2011
- 2011-04-04 CY CY20111100348T patent/CY1112793T1/el unknown
-
2012
- 2012-01-04 FR FR12C0001C patent/FR12C0001I2/fr active Active
- 2012-01-04 LU LU91926C patent/LU91926I2/fr unknown
- 2012-01-10 CY CY2012003C patent/CY2012003I2/el unknown
- 2012-01-12 BE BE2012C005C patent/BE2012C005I2/fr unknown
- 2012-01-23 US US13/356,314 patent/US9187548B2/en not_active Expired - Fee Related
-
2016
- 2016-12-13 CY CY20161101283T patent/CY1118317T1/el unknown
- 2016-12-19 CY CY20161101319T patent/CY1118363T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BE2012C005I2 (fr) | ||
WO2003055979A3 (fr) | Anticorps se liant à blys selon un mode immunospécifique | |
DK1385864T3 (da) | Anti-VEGF-2-antistoffer | |
WO2003054216A3 (fr) | Anticorps se liant de maniere immunospecifique a des recepteurs trail | |
MXPA03010747A (es) | Anticuerpos que se unen inmunoespecificamente a receptores de ligando inductor de apoptosis relacionado con factor de necrosis tumoral. | |
LU93274I2 (fr) | Elotuzumab | |
BR9811946A (pt) | Método para prevenção ou tratamento de distúrbios e doenças dependentes de estrogênio | |
BRPI0313792B8 (pt) | utilização de proteína de eritropoetina, método para tratamento de distúrbios de distribuição de ferro em diabetes e medicamento para o seu tratamento | |
PT911331E (pt) | Compostos de dibenzoxazepina substituidos composicoes farmaceuticas e metodos de utilizacao | |
BR0312768A (pt) | Compostos de 5-ariltetrazol, composições do mesmo e usos dos mesmos | |
EE200100179A (et) | Farmatseutilised agendid Parkinsoni tõve, ADHD jamikroadenoomide raviks | |
BR0009524A (pt) | Uso de um composto, e, composição farmacêutica ou veterinaria | |
BR0110208A (pt) | Composições e terapias para distúrbios associados com hiperlipidemia | |
KR100292396B1 (fr) | ||
WO2005016236A3 (fr) | Anticorps se liant de maniere immunospecifique aux recepteurs trail | |
WO2002079377A3 (fr) | Anticorps a liaison immunospecifique avec les recepteurs 'trail' | |
WO2004016753A3 (fr) | Anticorps se fixant de facon immunospecifique a des recepteurs trail | |
WO2003042367A3 (fr) | Anticorps se liant specifiquement au niveau immunitaire a des recepteurs trail | |
BR0213633A (pt) | Método e composto para tratar de uma doença associada com recrutamento e/ou ativação aberrante de leucócitos | |
WO2002036166A8 (fr) | Procedes et compositions stimulant le cd45 et supprimant de ce fait l'activation du microglial associee a la maladie d'alzheimer |