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MX2017007249A - Receptores de antigeno quimerico dirigidos al receptor fc 5 similar y sus usos. - Google Patents

Receptores de antigeno quimerico dirigidos al receptor fc 5 similar y sus usos.

Info

Publication number
MX2017007249A
MX2017007249A MX2017007249A MX2017007249A MX2017007249A MX 2017007249 A MX2017007249 A MX 2017007249A MX 2017007249 A MX2017007249 A MX 2017007249A MX 2017007249 A MX2017007249 A MX 2017007249A MX 2017007249 A MX2017007249 A MX 2017007249A
Authority
MX
Mexico
Prior art keywords
similar receiver
antigen
fcrls
chemeric
similar
Prior art date
Application number
MX2017007249A
Other languages
English (en)
Other versions
MX395028B (es
Inventor
Liu Cheng
Renier J Brentjens
L Smith Eric
Original Assignee
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Publication of MX2017007249A publication Critical patent/MX2017007249A/es
Publication of MX395028B publication Critical patent/MX395028B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/7056—Lectin superfamily, e.g. CD23, CD72
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    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
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Abstract

El asunto ahora descrito proporciona los métodos y las composiciones para tratar una neoplasia (por ejemplo, mieloma múltiple); se refiere a receptores de antígeno quimérico (CAR) que se dirige específicamente al receptor Fc 5 similar (FcRL5), por ejemplo, dominio 9 del FcRLS, y células inmunorreactivas que comprenden tales los CAR; los CAR dirigidos al FcRLS descritos en la presente tienen propiedades de inmunoactivadoras mejoradas que incluyen actividad antitumoral.
MX2017007249A 2014-12-05 2015-12-04 Receptores de antigeno quimerico dirigidos al receptor fc 5 similar y sus usos. MX395028B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462088164P 2014-12-05 2014-12-05
PCT/US2015/064134 WO2016090337A1 (en) 2014-12-05 2015-12-04 Chimeric antigen receptors targeting fc receptor-like 5 and uses thereof

Publications (2)

Publication Number Publication Date
MX2017007249A true MX2017007249A (es) 2018-01-25
MX395028B MX395028B (es) 2025-03-24

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MX2017007249A MX395028B (es) 2014-12-05 2015-12-04 Receptores de antigeno quimerico dirigidos al receptor fc 5 similar y sus usos.

Country Status (15)

Country Link
US (3) US11059891B2 (es)
EP (2) EP4506036A3 (es)
JP (3) JP7174522B2 (es)
KR (1) KR20170108946A (es)
CN (2) CN109072199B (es)
AU (2) AU2015357543B2 (es)
BR (1) BR112017011936A8 (es)
CA (1) CA2974434A1 (es)
IL (2) IL252655B (es)
MX (1) MX395028B (es)
MY (1) MY192062A (es)
NZ (1) NZ732570A (es)
PH (1) PH12017501041A1 (es)
SG (2) SG10202008076RA (es)
WO (1) WO2016090337A1 (es)

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