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SA519401072B1 - Bcma مستقبلات مولد ضد خيمري تستهدف وطرق استخدامها - Google Patents

Bcma مستقبلات مولد ضد خيمري تستهدف وطرق استخدامها

Info

Publication number
SA519401072B1
SA519401072B1 SA519401072A SA519401072A SA519401072B1 SA 519401072 B1 SA519401072 B1 SA 519401072B1 SA 519401072 A SA519401072 A SA 519401072A SA 519401072 A SA519401072 A SA 519401072A SA 519401072 B1 SA519401072 B1 SA 519401072B1
Authority
SA
Saudi Arabia
Prior art keywords
chimeric antigen
antigen receptors
methods
targeting bcma
bcma
Prior art date
Application number
SA519401072A
Other languages
English (en)
Inventor
وانغ بينغيان
هاو جياينغ
زاهو دان
فان كسياوهو
هي كسيتان
زهوانغ كيوتشوان
يانغ لي
وانغ لين
Original Assignee
ليجيند بيوتيك إريلاند ليميتد
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ليجيند بيوتيك إريلاند ليميتد filed Critical ليجيند بيوتيك إريلاند ليميتد
Publication of SA519401072B1 publication Critical patent/SA519401072B1/ar

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    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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Abstract

يتعلق الاختراع الحالي بتوفير أجسام مضادة لنطاق أحادي تستهدف BCMA، ومستقبلات مولد ضد خيمري (مثل CAR أحادي التكافؤ، وCAR عديد التكافؤ يتضمن CAR ثنائي القمة اللاصقة) تشتمل على واحد أو أكثر من أجسام مضادة ذات نطاق أحادي لمضاد BCMA . كما تم توفير خلايا مؤثرة مناعية معالَجة وراثيًا (مثل خلايا تائية) تشتمل على مستقبلات مولد الضد الخيمري. كما تم توفير تركيبات صيدلية، أطقم وطرق لعلاج السرطان.
SA519401072A 2015-08-11 2019-02-10 Bcma مستقبلات مولد ضد خيمري تستهدف وطرق استخدامها SA519401072B1 (ar)

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