|
USRE47770E1
(en)
|
2002-07-18 |
2019-12-17 |
Merus N.V. |
Recombinant production of mixtures of antibodies
|
|
ES2368733T3
(es)
|
2002-07-18 |
2011-11-21 |
Merus B.V. |
Producción recombinante de mezclas de anticuerpos.
|
|
ES2592271T3
(es)
|
2005-03-31 |
2016-11-29 |
Chugai Seiyaku Kabushiki Kaisha |
Métodos de producción de polipéptidos mediante la regulación de la asociación de los polipéptidos
|
|
WO2007114325A1
(ja)
|
2006-03-31 |
2007-10-11 |
Chugai Seiyaku Kabushiki Kaisha |
二重特異性抗体を精製するための抗体改変方法
|
|
EP4001409A1
(en)
|
2006-03-31 |
2022-05-25 |
Chugai Seiyaku Kabushiki Kaisha |
Methods for controlling blood pharmacokinetics of antibodies
|
|
CA2681974C
(en)
|
2007-03-29 |
2019-12-31 |
Genmab A/S |
Bispecific antibodies and methods for production thereof
|
|
CA2700394C
(en)
|
2007-09-26 |
2017-10-24 |
Chugai Seiyaku Kabushiki Kaisha |
Modified antibody constant region
|
|
DK2202245T3
(en)
|
2007-09-26 |
2016-11-21 |
Chugai Pharmaceutical Co Ltd |
A method of modifying an antibody isoelectric point VIA amino acid substitution in CDR
|
|
US20090162359A1
(en)
|
2007-12-21 |
2009-06-25 |
Christian Klein |
Bivalent, bispecific antibodies
|
|
AU2009204501B2
(en)
*
|
2008-01-07 |
2015-02-12 |
Amgen Inc. |
Method for making antibody Fc-heterodimeric molecules using electrostatic steering effects
|
|
KR20190128002A
(ko)
|
2008-06-26 |
2019-11-13 |
악셀레론 파마 인코포레이티드 |
액티빈-ａｃｔｒｉｉａ 길항물질을 투약하는 방법 및 치료된 환자의 모니터링
|
|
JP5787446B2
(ja)
|
2009-03-19 |
2015-09-30 |
中外製薬株式会社 |
抗体定常領域改変体
|
|
MX2011010168A
(es)
|
2009-04-07 |
2011-10-11 |
Roche Glycart Ag |
Anticuerpos biespecificos, trivalentes.
|
|
US9676845B2
(en)
|
2009-06-16 |
2017-06-13 |
Hoffmann-La Roche, Inc. |
Bispecific antigen binding proteins
|
|
US9493578B2
(en)
*
|
2009-09-02 |
2016-11-15 |
Xencor, Inc. |
Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
|
|
KR20120108967A
(ko)
|
2009-09-16 |
2012-10-05 |
제넨테크, 인크. |
코일드 코일 및/또는 테더 함유 단백질 복합체 및 그의 용도
|
|
JP5889181B2
(ja)
|
2010-03-04 |
2016-03-22 |
中外製薬株式会社 |
抗体定常領域改変体
|
|
TW201138821A
(en)
|
2010-03-26 |
2011-11-16 |
Roche Glycart Ag |
Bispecific antibodies
|
|
NZ701825A
(en)
|
2010-04-20 |
2016-06-24 |
Genmab As |
Heterodimeric antibody fc-containing proteins and methods for production thereof
|
|
EP3539988A3
(en)
|
2010-05-27 |
2019-12-04 |
Genmab A/S |
Monoclonal antibodies against her2
|
|
CN103052649B
(zh)
|
2010-07-29 |
2015-12-16 |
Xencor公司 |
具有修改的等电点的抗体
|
|
WO2012020096A1
(en)
*
|
2010-08-13 |
2012-02-16 |
Medimmune Limited |
Monomeric polypeptides comprising variant fc regions and methods of use
|
|
JP6167040B2
(ja)
*
|
2010-11-05 |
2017-07-19 |
ザイムワークス，インコーポレイテッド |
Ｆｃドメイン中に突然変異を有する、安定したヘテロ二量体抗体の設計
|
|
TWI452136B
(zh)
|
2010-11-17 |
2014-09-11 |
中外製藥股份有限公司 |
A multiple specific antigen-binding molecule that replaces the function of Factor VIII in blood coagulation
|
|
CA2824824A1
(en)
|
2011-02-28 |
2012-09-07 |
F. Hoffmann-La Roche Ag |
Monovalent antigen binding proteins
|
|
BR112013019975A2
(pt)
|
2011-02-28 |
2017-08-01 |
Hoffmann La Roche |
proteínas de ligação de antígeno, composição farmacêutica, uso de uma proteína de ligação de antígeno, método para o tratamento de um paciente e método para a preparação de uma proteína de ligação de antígeno, ácido nucleico, vetor e célula hospedeira"
|
|
WO2012116453A1
(en)
|
2011-03-03 |
2012-09-07 |
Zymeworks Inc. |
Multivalent heteromultimer scaffold design and constructs
|
|
CA2830254C
(en)
|
2011-03-16 |
2019-09-10 |
Amgen Inc. |
Fc variants
|
|
KR20200052383A
(ko)
|
2011-03-25 |
2020-05-14 |
아이크노스 사이언스 에스. 아. |
헤테로 이량체 면역글로불린
|
|
JP5977814B2
(ja)
|
2011-04-08 |
2016-08-24 |
アムジエン・インコーポレーテツド |
増殖分化因子１５（ｇｄｆ−１５）を使用して代謝障害を治療または改善する方法
|
|
CN103796677B
(zh)
*
|
2011-04-20 |
2019-08-16 |
健玛保 |
针对her2和cd3的双特异性抗体
|
|
MX382929B
(es)
*
|
2011-06-30 |
2025-03-13 |
Chugai Pharmaceutical Co Ltd |
Polipéptido heterodimerizado.
|
|
UA117901C2
(uk)
|
2011-07-06 |
2018-10-25 |
Ґенмаб Б.В. |
Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування
|
|
WO2013022855A1
(en)
*
|
2011-08-05 |
2013-02-14 |
Xencor, Inc. |
Antibodies with modified isoelectric points and immunofiltering
|
|
RU2605390C2
(ru)
|
2011-08-23 |
2016-12-20 |
Рош Гликарт Аг |
Биспецифические антитела, специфичные к антигенам, активирующим т-клетки, и опухолевому антигену, и способы их применения
|
|
GB201116092D0
(en)
|
2011-09-16 |
2011-11-02 |
Bioceros B V |
Antibodies and uses thereof
|
|
CA2851534C
(en)
*
|
2011-10-10 |
2023-02-14 |
Xencor, Inc. |
A method for purifying antibodies
|
|
US10851178B2
(en)
|
2011-10-10 |
2020-12-01 |
Xencor, Inc. |
Heterodimeric human IgG1 polypeptides with isoelectric point modifications
|
|
SG10201805291TA
(en)
|
2011-10-27 |
2018-08-30 |
Genmab As |
Production of heterodimeric proteins
|
|
BR112014010257A2
(pt)
|
2011-10-31 |
2017-04-18 |
Chugai Pharmaceutical Co Ltd |
molécula de ligação ao antígeno tendo conjugação regulada entre cadeias pesadas e cadeias leves
|
|
WO2013063702A1
(en)
|
2011-11-04 |
2013-05-10 |
Zymeworks Inc. |
Stable heterodimeric antibody design with mutations in the fc domain
|
|
CN108864291A
(zh)
|
2011-11-23 |
2018-11-23 |
拜奥文斯瑞有限公司 |
重组蛋白及其治疗用途
|
|
EP2804631B1
(en)
|
2012-01-20 |
2021-03-17 |
i2 Pharmaceuticals, Inc. |
Surrobody conjugates
|
|
CA2862745A1
(en)
|
2012-01-26 |
2013-08-01 |
Amgen Inc. |
Growth differentiation factor 15 (gdf-15) polypeptides
|
|
CN113527469A
(zh)
|
2012-02-09 |
2021-10-22 |
中外制药株式会社 |
抗体的Fc区变异体
|
|
PL2838917T3
(pl)
|
2012-04-20 |
2019-12-31 |
Merus N.V. |
Sposoby i środki do wytwarzania heterodimerycznych cząsteczek podobnych do Ig
|
|
US9090694B2
(en)
|
2012-04-30 |
2015-07-28 |
Janssen Biotech, Inc. |
ST2L antibody antagonists
|
|
EP2847230B1
(en)
*
|
2012-05-10 |
2020-08-12 |
Zymeworks Inc. |
Heteromultimer constructs of immunoglobulin heavy chains with mutations in the fc domain
|
|
EP2847224A4
(en)
*
|
2012-05-10 |
2016-04-27 |
Zymeworks Inc |
SINGLE ARM MONOVALENT ANTIBODY CONSTRUCTS AND USES THEREOF
|
|
WO2013187495A1
(ja)
|
2012-06-14 |
2013-12-19 |
中外製薬株式会社 |
改変されたFc領域を含む抗原結合分子
|
|
US9499634B2
(en)
|
2012-06-25 |
2016-11-22 |
Zymeworks Inc. |
Process and methods for efficient manufacturing of highly pure asymmetric antibodies in mammalian cells
|
|
EP3632462A1
(en)
|
2012-07-06 |
2020-04-08 |
Genmab B.V. |
Dimeric protein with triple mutations
|
|
JP6514103B2
(ja)
|
2012-07-06 |
2019-05-15 |
ゲンマブ ビー．ブイ． |
三重変異を有する二量体タンパク質
|
|
KR20150036606A
(ko)
*
|
2012-07-13 |
2015-04-07 |
자임워크스 인코포레이티드 |
항-cd3 구조체를 포함하는 이중특이적 비대칭 이형이합체
|
|
AU2013289881B2
(en)
|
2012-07-13 |
2018-01-18 |
Zymeworks Bc Inc. |
Multivalent heteromultimer scaffold design and constructs
|
|
JP2015531751A
(ja)
*
|
2012-07-23 |
2015-11-05 |
ザイムワークス，インコーポレイテッド |
選択的対である軽鎖および重鎖を含む免疫グロブリン構築物
|
|
EP2889376A4
(en)
|
2012-08-24 |
2016-11-02 |
Chugai Pharmaceutical Co Ltd |
ANTIBODIES Fc SPECIFIC TO FCTRII OF MOUSE
|
|
SG11201500873XA
(en)
|
2012-08-24 |
2015-04-29 |
Chugai Pharmaceutical Co Ltd |
Fcgriib-specific fc region variant
|
|
ES2692951T3
(es)
|
2012-09-27 |
2018-12-05 |
Merus N.V. |
Anticuerpos IgG biespecíficos como acopladores de células T
|
|
US9771573B2
(en)
|
2012-10-03 |
2017-09-26 |
Zymeworks Inc. |
Methods of quantitating heavy and light chain polypeptide pairs
|
|
US10087250B2
(en)
|
2012-10-08 |
2018-10-02 |
Roche Glycart Ag |
Fc-free antibodies comprising two fab-fragments and methods of use
|
|
CA2889951C
(en)
*
|
2012-11-02 |
2023-04-18 |
Zymeworks Inc. |
Crystal structures of heterodimeric fc domains
|
|
ES2700231T3
(es)
|
2012-11-21 |
2019-02-14 |
Janssen Biotech Inc |
Anticuerpos de EGFR/c-Met biespecíficos
|
|
US20170275367A1
(en)
|
2012-11-21 |
2017-09-28 |
Janssen Biotech, Inc. |
Bispecific EGFR/C-Met Antibodies
|
|
CA2892059C
(en)
*
|
2012-11-21 |
2023-02-14 |
Wuhan Yzy Biopharma Co., Ltd. |
Bispecific antibody
|
|
CA2892623C
(en)
*
|
2012-11-27 |
2020-08-11 |
Ajou University Industry-Academic Cooperation Foundation |
Ch3 domain variant pair inducing formation of heterodimer of heavy chain constant region of antibody at high efficiency, method for preparing same, and use thereof
|
|
KR102264570B1
(ko)
|
2012-11-28 |
2021-06-14 |
자임워크스 인코포레이티드 |
가공된 면역글로불린 중쇄-경쇄 쌍 및 이들의 용도
|
|
US9914785B2
(en)
|
2012-11-28 |
2018-03-13 |
Zymeworks Inc. |
Engineered immunoglobulin heavy chain-light chain pairs and uses thereof
|
|
ES2876009T3
(es)
|
2012-12-27 |
2021-11-11 |
Chugai Pharmaceutical Co Ltd |
Polipéptido heterodimerizado
|
|
KR20210096697A
(ko)
|
2013-01-10 |
2021-08-05 |
젠맵 비. 브이 |
인간 IgG1 Fc 영역 변이체 및 그의 용도
|
|
US10487155B2
(en)
|
2013-01-14 |
2019-11-26 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US9701759B2
(en)
|
2013-01-14 |
2017-07-11 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US10968276B2
(en)
|
2013-03-12 |
2021-04-06 |
Xencor, Inc. |
Optimized anti-CD3 variable regions
|
|
US10131710B2
(en)
|
2013-01-14 |
2018-11-20 |
Xencor, Inc. |
Optimized antibody variable regions
|
|
US9605084B2
(en)
|
2013-03-15 |
2017-03-28 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US11053316B2
(en)
|
2013-01-14 |
2021-07-06 |
Xencor, Inc. |
Optimized antibody variable regions
|
|
CA3211863A1
(en)
*
|
2013-01-14 |
2014-07-17 |
Xencor, Inc. |
Novel heterodimeric proteins
|
|
EP2945969A1
(en)
|
2013-01-15 |
2015-11-25 |
Xencor, Inc. |
Rapid clearance of antigen complexes using novel antibodies
|
|
EP2954056A4
(en)
|
2013-02-08 |
2016-09-21 |
Stemcentrx Inc |
NEW MULTISPECIFIC CONSTRUCTIONS
|
|
JP6133444B2
(ja)
|
2013-02-26 |
2017-05-24 |
ロシュ グリクアート アーゲー |
二重特異性ｔ細胞活性化抗原結合分子
|
|
CA2896370A1
(en)
|
2013-02-26 |
2014-09-04 |
Roche Glycart Ag |
Bispecific t cell activating antigen binding molecules
|
|
WO2014145907A1
(en)
|
2013-03-15 |
2014-09-18 |
Xencor, Inc. |
Targeting t cells with heterodimeric proteins
|
|
HRP20191470T1
(hr)
*
|
2013-03-15 |
2020-01-10 |
Xencor, Inc. |
Heterodimerni proteini
|
|
US10858417B2
(en)
|
2013-03-15 |
2020-12-08 |
Xencor, Inc. |
Heterodimeric proteins
|
|
CA2906526C
(en)
|
2013-03-15 |
2022-12-06 |
Ellen Chi |
Interferon alpha and omega antibody antagonists
|
|
US10519242B2
(en)
|
2013-03-15 |
2019-12-31 |
Xencor, Inc. |
Targeting regulatory T cells with heterodimeric proteins
|
|
US10106624B2
(en)
|
2013-03-15 |
2018-10-23 |
Xencor, Inc. |
Heterodimeric proteins
|
|
SMT201800503T1
(it)
|
2013-03-18 |
2018-11-09 |
Janssen Pharmaceuticals Inc |
Anticorpi anti-cd (ox40) umanizzati e loro usi
|
|
CN113621057A
(zh)
|
2013-04-02 |
2021-11-09 |
中外制药株式会社 |
Fc区变体
|
|
KR20160003803A
(ko)
|
2013-04-29 |
2016-01-11 |
에프. 호프만-라 로슈 아게 |
FcRn 결합이 제거된 항-IGF-1R 항체 및 혈관 눈 질환의 치료에 있어서 이의 용도
|
|
CA2904805A1
(en)
|
2013-04-29 |
2014-11-06 |
F. Hoffmann-La Roche Ag |
Fc-receptor binding modified asymmetric antibodies and methods of use
|
|
CN105143262A
(zh)
|
2013-04-29 |
2015-12-09 |
豪夫迈·罗氏有限公司 |
结合人fcrn的修饰的抗体和使用方法
|
|
EP2994164B1
(en)
|
2013-05-08 |
2020-08-05 |
Zymeworks Inc. |
Bispecific her2 and her3 antigen binding constructs
|
|
BR112015029788B1
(pt)
|
2013-05-31 |
2024-01-02 |
Zymeworks Inc |
HETERO-MULTÍMERO, USO E MÉTODO PARA PREPARAR DO MESMO, COMPOSIÇÃO FARMACÊUTICA E MÉTODO PARA REDUZIR FUNÇÃO EFETORA DE UM CONSTRUTO IgG FC
|
|
KR20250078622A
(ko)
|
2013-07-05 |
2025-06-02 |
젠맵 에이/에스 |
인간화 또는 키메라 cd3 항체
|
|
AU2014287011A1
(en)
*
|
2013-07-12 |
2016-02-25 |
Zymeworks Inc. |
Bispecific CD3 and CD19 antigen binding constructs
|
|
AR097181A1
(es)
*
|
2013-07-31 |
2016-02-24 |
Amgen Inc |
Construcciones del factor de diferenciación de crecimiento 15 (gdf-15)
|
|
CA2925256C
(en)
*
|
2013-09-27 |
2023-08-15 |
Chugai Seiyaku Kabushiki Kaisha |
Method for producing polypeptide heteromultimer
|
|
MX2016003593A
(es)
|
2013-10-11 |
2016-06-02 |
Hoffmann La Roche |
Anticuerpos de cadena ligera variable comun intercambiada de dominio multiespecifico.
|
|
NZ758354A
(en)
|
2013-11-06 |
2022-09-30 |
Janssen Biotech Inc |
Anti-ccl17 antibodies
|
|
CN113278076A
(zh)
|
2013-11-11 |
2021-08-20 |
中外制药株式会社 |
含有改变了抗体可变区的抗原结合分子
|
|
MX2016006301A
(es)
*
|
2013-11-13 |
2016-12-16 |
Zymeworks Inc |
Construcciones de unión a antígeno monovalente que se dirigen a egfr y/o her2, y sus usos.
|
|
EP4570318A2
(en)
|
2013-11-27 |
2025-06-18 |
Zymeworks BC Inc. |
Bispecific antigen-binding constructs targeting her2
|
|
PE20210648A1
(es)
|
2013-12-17 |
2021-03-26 |
Genentech Inc |
Anticuerpos anti-cd3 y metodos de uso
|
|
PL3083680T3
(pl)
|
2013-12-20 |
2020-06-29 |
F. Hoffmann-La Roche Ag |
Humanizowane przeciwciała przeciwko białku tau(pS422) i sposoby stosowania
|
|
CN111228509A
(zh)
|
2014-01-03 |
2020-06-05 |
豪夫迈·罗氏有限公司 |
双特异性抗-半抗原/抗-血脑屏障受体的抗体、其复合物及其作为血脑屏障穿梭物的应用
|
|
CN111057147B
(zh)
|
2014-01-06 |
2023-11-10 |
豪夫迈·罗氏有限公司 |
单价血脑屏障穿梭模块
|
|
EP2891664A1
(en)
*
|
2014-01-07 |
2015-07-08 |
Technische Universität München |
Novel methods for the stabilisation of immunoglobulin constant domains
|
|
US20160326249A1
(en)
*
|
2014-01-15 |
2016-11-10 |
Zymeworks Inc. |
Bi-specific cd3 and cd19 antigen-binding constructs
|
|
CA2932364A1
(en)
|
2014-01-15 |
2015-07-23 |
F. Hoffmann-La Roche Ag |
Fc-region variants with improved protein a-binding
|
|
RU2727639C2
(ru)
|
2014-01-15 |
2020-07-22 |
Ф.Хоффманн-Ля Рош Аг |
Варианты fc-области с модифицированной способностью связываться с fcrn и с сохраненной способностью связываться с белком а
|
|
EP3786186A1
(en)
|
2014-02-28 |
2021-03-03 |
Merus N.V. |
Antibodies that bind egfr and erbb3
|
|
US9732154B2
(en)
|
2014-02-28 |
2017-08-15 |
Janssen Biotech, Inc. |
Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia
|
|
KR20160145560A
(ko)
|
2014-02-28 |
2016-12-20 |
메뤼스 엔.페. |
ErbB-2와 ErbB-3에 결합하는 항체
|
|
HRP20200164T1
(hr)
|
2014-03-28 |
2020-05-01 |
Xencor, Inc. |
Bispecifična protutijela koja se vežu na cd38 i cd3
|
|
UA117289C2
(uk)
|
2014-04-02 |
2018-07-10 |
Ф. Хоффманн-Ля Рош Аг |
Мультиспецифічне антитіло
|
|
SG11201608054YA
(en)
|
2014-04-02 |
2016-10-28 |
Hoffmann La Roche |
Method for detecting multispecific antibody light chain mispairing
|
|
PL3130606T3
(pl)
|
2014-04-07 |
2022-02-07 |
Chugai Seiyaku Kabushiki Kaisha |
Przeciwciała dwuswoiste aktywujące układ odpornościowy
|
|
AU2015252866B2
(en)
|
2014-05-02 |
2021-01-28 |
Momenta Pharmaceuticals, Inc. |
Compositions and methods related to engineered Fc constructs
|
|
TW201623333A
(zh)
|
2014-05-13 |
2016-07-01 |
Chugai Pharmaceutical Co Ltd |
對具有免疫抑制機能之細胞的ｔ細胞重定向抗原結合分子
|
|
US11306156B2
(en)
|
2014-05-28 |
2022-04-19 |
Zymeworks Inc. |
Modified antigen binding polypeptide constructs and uses thereof
|
|
MX382908B
(es)
|
2014-06-04 |
2025-03-13 |
Acceleron Pharma Inc |
Polipéptidos de folistatina y sus usos.
|
|
US10010498B2
(en)
|
2014-06-04 |
2018-07-03 |
Acceleron Pharma Inc. |
Methods for treatment of amyotrophic lateral sclerosis with follistatin fusion proteins
|
|
TWI713453B
(zh)
|
2014-06-23 |
2020-12-21 |
美商健生生物科技公司 |
干擾素α及ω抗體拮抗劑
|
|
KR20170026362A
(ko)
|
2014-06-26 |
2017-03-08 |
에프. 호프만-라 로슈 아게 |
항-ｂｒｄｕ 항체 및 사용 방법
|
|
AR100978A1
(es)
|
2014-06-26 |
2016-11-16 |
Hoffmann La Roche |
LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS
|
|
KR102586656B1
(ko)
|
2014-07-11 |
2023-10-11 |
젠맵 에이/에스 |
Ａｘｌ에 결합하는 항체
|
|
EP2982692A1
(en)
|
2014-08-04 |
2016-02-10 |
EngMab AG |
Bispecific antibodies against CD3epsilon and BCMA
|
|
EA038958B1
(ru)
|
2014-08-04 |
2021-11-15 |
Ф. Хоффманн-Ля Рош Аг |
Биспецифические антигенсвязывающие молекулы, активирующие т-клетки
|
|
DK3189081T3
(da)
|
2014-09-05 |
2020-05-04 |
Janssen Pharmaceutica Nv |
Cd123-bindende midler og anvendelser deraf
|
|
JP6707531B2
(ja)
|
2014-09-09 |
2020-06-10 |
ヤンセン バイオテツク，インコーポレーテツド |
抗ｃｄ３８抗体による併用療法
|
|
MX2017003022A
(es)
|
2014-09-12 |
2017-05-12 |
Genentech Inc |
Anticuerpos anti-cll-1 e inmunoconjugados.
|
|
MA40764A
(fr)
|
2014-09-26 |
2017-08-01 |
Chugai Pharmaceutical Co Ltd |
Agent thérapeutique induisant une cytotoxicité
|
|
WO2016055592A1
(en)
|
2014-10-09 |
2016-04-14 |
Engmab Ag |
Bispecific antibodies against cd3epsilon and ror1
|
|
US11773166B2
(en)
|
2014-11-04 |
2023-10-03 |
Ichnos Sciences SA |
CD3/CD38 T cell retargeting hetero-dimeric immunoglobulins and methods of their production
|
|
JP6576456B2
(ja)
|
2014-11-06 |
2019-09-18 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
修飾されたＦｃＲｎ結合特性およびプロテインＡ結合特性を有するＦｃ領域変種
|
|
MX378451B
(es)
|
2014-11-06 |
2025-03-11 |
Hoffmann La Roche |
Variantes de regiòn fc con uniòn del receptor fc neonatal (fcrn) modificado y mètodos de uso.
|
|
TWI740809B
(zh)
|
2014-11-11 |
2021-10-01 |
日商中外製藥股份有限公司 |
包含經改變之抗體可變區之抗原結合分子的資料庫
|
|
EP3023437A1
(en)
|
2014-11-20 |
2016-05-25 |
EngMab AG |
Bispecific antibodies against CD3epsilon and BCMA
|
|
FI4141032T3
(fi)
|
2014-11-20 |
2024-07-31 |
Hoffmann La Roche |
T-solua aktivoivien bispesifisten antigeeniä sitovien molekyylien ja pd-1-akselia sitovien antagonistien yhdistelmähoito
|
|
CA2968162A1
(en)
|
2014-11-20 |
2016-05-26 |
F. Hoffmann-La Roche Ag |
Common light chains and methods of use
|
|
DK3221356T3
(da)
|
2014-11-20 |
2020-11-02 |
Hoffmann La Roche |
T-celleaktiverende, bispecifikke, antigenbindende molekyler mod folr1 og cd3
|
|
US10259887B2
(en)
|
2014-11-26 |
2019-04-16 |
Xencor, Inc. |
Heterodimeric antibodies that bind CD3 and tumor antigens
|
|
PE20171103A1
(es)
|
2014-11-26 |
2017-08-07 |
Xencor Inc |
Anticuerpos heterodimericos que se unen a cd3 y cd38
|
|
DK3223845T3
(da)
|
2014-11-26 |
2021-08-16 |
Xencor Inc |
Heterodimere antistoffer, der binder cd3 og cd20
|
|
ES3014819T3
(en)
|
2014-11-27 |
2025-04-25 |
Zymeworks Bc Inc |
Methods of using bispecific antigen-binding constructs targeting her2
|
|
JP6721590B2
(ja)
|
2014-12-03 |
2020-07-15 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
多重特異性抗体
|
|
CA2969717A1
(en)
|
2014-12-04 |
2016-06-09 |
Janssen Biotech, Inc. |
Anti-cd38 antibodies for treatment of acute myeloid leukemia
|
|
AR103161A1
(es)
|
2014-12-19 |
2017-04-19 |
Chugai Pharmaceutical Co Ltd |
Anticuerpos antimiostatina y regiones fc variantes así como métodos de uso
|
|
DK3233907T3
(da)
|
2014-12-19 |
2021-06-07 |
Genmab As |
Bispecifikke heterodimeriske proteiner hos gnavere
|
|
EP3237449A2
(en)
|
2014-12-22 |
2017-11-01 |
Xencor, Inc. |
Trispecific antibodies
|
|
MA41375A
(fr)
|
2015-01-22 |
2017-11-28 |
Lilly Co Eli |
Anticorps igg bispécifiques et leurs procédés de préparation
|
|
CN104610453A
(zh)
*
|
2015-01-23 |
2015-05-13 |
张帆 |
一类抗her2双靶向抗体、其制备方法及用途
|
|
US10227411B2
(en)
|
2015-03-05 |
2019-03-12 |
Xencor, Inc. |
Modulation of T cells with bispecific antibodies and FC fusions
|
|
WO2016154601A1
(en)
|
2015-03-26 |
2016-09-29 |
Acceleron Pharma Inc. |
Follistatin-related fusion proteins and uses thereof
|
|
WO2016159213A1
(ja)
|
2015-04-01 |
2016-10-06 |
中外製薬株式会社 |
ポリペプチド異種多量体の製造方法
|
|
MA42059A
(fr)
|
2015-05-06 |
2018-03-14 |
Janssen Biotech Inc |
Agents de liaison bispécifique à l'antigène membranaire spécifique de la prostate (psma) et utilisations de ceux-ci
|
|
CR20170511A
(es)
|
2015-05-08 |
2018-01-22 |
Xencor Inc |
Anticuerpos heterodiméricos que se unen a cd3 y a antígenos tumorales.
|
|
EP3297729A4
(en)
|
2015-05-20 |
2019-04-10 |
Janssen Biotech, Inc. |
ANTI-CD38 ANTIBODIES FOR THE TREATMENT OF LIGHT-CHAINED AMYLOIDOSES AND OTHER CD38-POSITIVE HEMATOLOGICAL MALIGNITIES
|
|
TWI773646B
(zh)
|
2015-06-08 |
2022-08-11 |
美商宏觀基因股份有限公司 |
結合lag-3的分子和其使用方法
|
|
HRP20231134T1
(hr)
|
2015-06-16 |
2024-01-05 |
F. Hoffmann - La Roche Ag |
Humanizirana i afinitetno zrela protutijela na fcrh5 i postupci za uporabu
|
|
JP6996983B2
(ja)
|
2015-06-16 |
2022-02-21 |
ジェネンテック， インコーポレイテッド |
抗ｃｌｌ－１抗体及び使用方法
|
|
MY192978A
(en)
|
2015-06-22 |
2022-09-20 |
Janssen Biotech Inc |
Combination therapies for heme malignancies with anti-cd38 antibodies and survivin inhibitors
|
|
PL3313877T3
(pl)
|
2015-06-24 |
2020-11-02 |
F. Hoffmann-La Roche Ag |
Humanizowane przeciwciała przeciwko białku tau(pS422) i sposoby stosowania
|
|
HRP20240338T1
(hr)
|
2015-06-24 |
2024-05-24 |
Janssen Biotech, Inc. |
Imunomodulacija i liječenje solidnih tumora s protutijelima koja se specifično vežu na cd38
|
|
JP7010811B2
(ja)
|
2015-07-10 |
2022-02-10 |
メルス ナムローゼ フェンノートシャップ |
ヒトｃｄ３結合抗体
|
|
ME03772B
(me)
|
2015-07-10 |
2021-04-20 |
Genmab As |
Konjugati antitijela specifičnog za axl i lijeka za liječenje kancera
|
|
US11147886B2
(en)
|
2015-07-15 |
2021-10-19 |
Zymeworks Inc. |
Drug-conjugated bi-specific antigen-binding constructs
|
|
JP2018526981A
(ja)
|
2015-07-15 |
2018-09-20 |
ゲンマブ エー／エス |
ヒト化またはキメラｃｄ３抗体
|
|
ES2846024T7
(es)
*
|
2015-07-24 |
2023-06-22 |
Gliknik Inc |
Proteínas de fusión de fragmentos de proteína humana para crear composiciones de Fc de inmunoglobulina multimerizada de forma ordenada con unión al complemento aumentada
|
|
PE20181151A1
(es)
|
2015-07-30 |
2018-07-17 |
Macrogenics Inc |
Moleculas de union a pd-1 y metodos de uso de las mismas
|
|
BR112018002319A2
(pt)
|
2015-08-05 |
2018-12-11 |
Janssen Biotech, Inc. |
anticorpos anti-cd154 e métodos de uso dos mesmos
|
|
HRP20201375T1
(hr)
|
2015-08-17 |
2020-11-27 |
Janssen Pharmaceutica Nv |
ANTI-BCMA ANTITIJELA, BISPECIFIČNI ANTIGEN VEŽUĆE MOLEKULE KOJE SE VEŽU ZA BCMA i CD3, I NJIHOVE UPOTREBE
|
|
EP3355921A4
(en)
|
2015-09-30 |
2019-05-22 |
Janssen Biotech, Inc. |
ANTAGONIST ANTIBODIES SPECIFICALLY BINDING TO HUMAN CD40 AND METHODS OF USE
|
|
AR106188A1
(es)
|
2015-10-01 |
2017-12-20 |
Hoffmann La Roche |
Anticuerpos anti-cd19 humano humanizados y métodos de utilización
|
|
RU2729371C1
(ru)
|
2015-10-02 |
2020-08-06 |
Ф. Хоффманн-Ля Рош Аг |
Биспецифические антитела, специфические к pd1 и tim3
|
|
JP6734919B2
(ja)
|
2015-10-02 |
2020-08-05 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
同時結合を測定するための細胞ベースのｆｒｅｔアッセイ法
|
|
BR112018000835A2
(pt)
|
2015-10-02 |
2018-09-11 |
Hoffmann La Roche |
molécula, um ou mais polinucleotídeos, um ou mais vetores, célula, método de produção da molécula, composição, uso da molécula, método de tratamento de uma doença e método para induzir a lise de uma célula-alvo
|
|
JP6937746B2
(ja)
|
2015-10-02 |
2021-09-22 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
二重特異性抗ｃｄ１９×ｃｄ３ｔ細胞活性化抗原結合分子
|
|
WO2017055395A1
(en)
|
2015-10-02 |
2017-04-06 |
F. Hoffmann-La Roche Ag |
Anti-cd3xrob04 bispecific t cell activating antigen binding molecules
|
|
EP3150637A1
(en)
|
2015-10-02 |
2017-04-05 |
F. Hoffmann-La Roche AG |
Multispecific antibodies
|
|
WO2017055388A2
(en)
|
2015-10-02 |
2017-04-06 |
F. Hoffmann-La Roche Ag |
Bispecific t cell activating antigen binding molecules
|
|
WO2017055385A1
(en)
|
2015-10-02 |
2017-04-06 |
F. Hoffmann-La Roche Ag |
Anti-cd3xgd2 bispecific t cell activating antigen binding molecules
|
|
WO2017055393A1
(en)
|
2015-10-02 |
2017-04-06 |
F. Hoffmann-La Roche Ag |
Anti-cd3xtim-3 bispecific t cell activating antigen binding molecules
|
|
WO2017055392A1
(en)
|
2015-10-02 |
2017-04-06 |
F. Hoffmann-La Roche Ag |
Anti-cd3xcd44v6 bispecific t cell activating antigen binding molecules
|
|
HK1254967A1
(zh)
|
2015-10-02 |
2019-08-02 |
豪夫迈‧罗氏有限公司 |
結合間皮素和cd3的雙特異性t細胞活化性抗原結合分子
|
|
UA128469C2
(uk)
|
2015-10-08 |
2024-07-24 |
Макродженікс, Інк. |
Спосіб лікування в7-н3-експресуючого раку
|
|
HK1257174A1
(zh)
|
2015-10-08 |
2019-10-18 |
Zymeworks Inc. |
包含κ和λ輕鏈的抗原結合多肽構建體及其用途
|
|
KR101851380B1
(ko)
|
2015-10-12 |
2018-04-23 |
아주대학교산학협력단 |
효모접합을 이용한 항체 ch3 도메인 이종이중체 돌연변이쌍 제조 방법 및 이에 의하여 제조된 ch3 돌연변이체 쌍
|
|
KR20180100305A
(ko)
|
2015-10-23 |
2018-09-10 |
메뤼스 엔.페. |
암 성장을 억제하는 결합 분자
|
|
JP6949016B2
(ja)
|
2015-10-29 |
2021-10-13 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
抗バリアントＦｃ領域抗体および使用法
|
|
EA201891084A1
(ru)
|
2015-11-02 |
2019-10-31 |
|
Антитела к il1rap, биспецифические антигенсвязывающие молекулы, которые связываются с il1rap и cd3, и их применение
|
|
EA201891093A1
(ru)
|
2015-11-03 |
2018-10-31 |
Янссен Байотек, Инк. |
Антитела, специфически связывающие pd-1, и их применение
|
|
SI3370770T1
(sl)
|
2015-11-03 |
2021-03-31 |
Janssen Biotech, Inc. |
Subkutane formulacije protiteles proti CD38 in njihove uporabe
|
|
US11660340B2
(en)
|
2015-11-18 |
2023-05-30 |
Chugai Seiyaku Kabushiki Kaisha |
Combination therapy using T cell redirection antigen binding molecule against cell having immunosuppressing function
|
|
US11649293B2
(en)
|
2015-11-18 |
2023-05-16 |
Chugai Seiyaku Kabushiki Kaisha |
Method for enhancing humoral immune response
|
|
KR20180098567A
(ko)
|
2015-12-01 |
2018-09-04 |
젠맵 비. 브이 |
항-dr5 항체 및 그의 사용 방법
|
|
WO2017100372A1
(en)
|
2015-12-07 |
2017-06-15 |
Xencor, Inc. |
Heterodimeric antibodies that bind cd3 and psma
|
|
EP3178848A1
(en)
|
2015-12-09 |
2017-06-14 |
F. Hoffmann-La Roche AG |
Type ii anti-cd20 antibody for reducing formation of anti-drug antibodies
|
|
PL3387015T3
(pl)
|
2015-12-09 |
2022-02-14 |
F. Hoffmann-La Roche Ag |
Przeciwciało anty-CD20 typu II do ograniczania tworzenia przeciwciał przeciwlekowych
|
|
CA3006462C
(en)
|
2015-12-14 |
2023-10-31 |
Macrogenics, Inc. |
Bispecific molecules having immunoreactivity with pd-1 and ctla-4, and methods of use thereof
|
|
CN106883297B
(zh)
*
|
2015-12-16 |
2019-12-13 |
苏州康宁杰瑞生物科技有限公司 |
基于ch3结构域的异二聚体分子、其制备方法及用途
|
|
JP2019502698A
(ja)
|
2015-12-17 |
2019-01-31 |
ヤンセン バイオテツク，インコーポレーテツド |
Ｈｌａ−ｄｒに特異的に結合する抗体及びその使用
|
|
MX2018007145A
(es)
|
2015-12-18 |
2018-08-15 |
Chugai Pharmaceutical Co Ltd |
Anticuerpos antimiostatina, polipeptidos que contienen regiones de fragmento cristalizable (fc) variantes y metodos de uso.
|
|
CN108368166B
(zh)
|
2015-12-28 |
2023-03-28 |
中外制药株式会社 |
提高含fc区多肽纯化效率的方法
|
|
ES2837428T3
(es)
|
2016-01-08 |
2021-06-30 |
Hoffmann La Roche |
Procedimientos de tratamiento de cánceres positivos para CEA usando antagonistas de unión al eje PD-1 y anticuerpos biespecíficos anti-CEA/anti-CD3
|
|
AR108034A1
(es)
|
2016-02-17 |
2018-07-11 |
Macrogenics Inc |
Moléculas de unión a ror1, y métodos de uso de las mismas
|
|
CN109069640B
(zh)
|
2016-03-14 |
2023-10-03 |
中外制药株式会社 |
用于癌症治疗的诱导细胞损伤的治疗药物
|
|
US11291721B2
(en)
|
2016-03-21 |
2022-04-05 |
Marengo Therapeutics, Inc. |
Multispecific and multifunctional molecules and uses thereof
|
|
HRP20230528T1
(hr)
|
2016-03-22 |
2023-08-04 |
F. Hoffmann - La Roche Ag |
Bispecifične molekule t stanica aktivirane proteazom
|
|
PE20190353A1
(es)
|
2016-04-15 |
2019-03-07 |
Macrogenics Inc |
Moleculas de union b7-h3 novedosas, conjugados anticuerpo-farmaco de los mismos y metodos de uso de los mismos
|
|
SG11201809620UA
(en)
|
2016-05-02 |
2018-11-29 |
Hoffmann La Roche |
The contorsbody - a single chain target binder
|
|
CA3025306A1
(en)
|
2016-05-23 |
2017-11-30 |
Momenta Pharmaceuticals, Inc. |
Compositions and methods related to engineered fc constructs
|
|
EP3252078A1
(en)
|
2016-06-02 |
2017-12-06 |
F. Hoffmann-La Roche AG |
Type ii anti-cd20 antibody and anti-cd20/cd3 bispecific antibody for treatment of cancer
|
|
WO2017214321A1
(en)
|
2016-06-07 |
2017-12-14 |
Gliknik Inc. |
Cysteine-optimized stradomers
|
|
WO2017218707A2
(en)
|
2016-06-14 |
2017-12-21 |
Xencor, Inc. |
Bispecific checkpoint inhibitor antibodies
|
|
CA3026518A1
(en)
*
|
2016-06-17 |
2017-12-21 |
Genentech, Inc. |
Purification of multispecific antibodies
|
|
KR102376582B1
(ko)
|
2016-06-17 |
2022-03-18 |
추가이 세이야쿠 가부시키가이샤 |
항-마이오스타틴 항체 및 사용 방법
|
|
EP3474895A1
(en)
|
2016-06-28 |
2019-05-01 |
UMC Utrecht Holding B.V. |
TREATMENT OF IgE-MEDIATED DISEASES WITH ANTIBODIES THAT SPECIFICALLY BIND CD38
|
|
EP3475304B1
(en)
|
2016-06-28 |
2022-03-23 |
Xencor, Inc. |
Heterodimeric antibodies that bind somatostatin receptor 2
|
|
CN119120423A
(zh)
|
2016-07-01 |
2024-12-13 |
分解治疗有限责任公司 |
优化的二核酸酶融合体和方法
|
|
JP6983824B2
(ja)
|
2016-07-04 |
2021-12-17 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
新規抗体フォーマット
|
|
KR20240017129A
(ko)
|
2016-07-14 |
2024-02-06 |
젠맵 에이/에스 |
Cd40 및 cd137에 대한 다중특이적 항체
|
|
SG11201900373WA
(en)
*
|
2016-07-19 |
2019-02-27 |
Ibentrus Inc |
Bispecific proteins and methods for preparing same
|
|
TWI781108B
(zh)
|
2016-07-20 |
2022-10-21 |
比利時商健生藥品公司 |
抗ｇｐｒｃ５ｄ抗體、結合ｇｐｒｃ５ｄ與ｃｄ３之雙特異性抗原結合分子及其用途
|
|
WO2018026942A1
(en)
*
|
2016-08-02 |
2018-02-08 |
Merrimack Pharmaceuticals, Inc. |
Heteromeric polypeptides
|
|
AU2017310163B2
(en)
|
2016-08-10 |
2021-09-09 |
Ajou University Industry-Academic Cooperation Foundation |
Heterodimeric Fc-fused cytokine and pharmaceutical composition comprising the same
|
|
KR102554331B1
(ko)
|
2016-08-12 |
2023-07-10 |
얀센 바이오테크 인코포레이티드 |
향상된 효능적 활성을 갖는 Fc 조작된 항-TNFR 수퍼패밀리 구성원 항체 및 그의 사용 방법
|
|
CN109863170B
(zh)
|
2016-08-12 |
2024-08-16 |
詹森生物科技公司 |
具有增强的激动作用和效应子功能的工程化抗体及其他含Fc结构域分子
|
|
US10793632B2
(en)
|
2016-08-30 |
2020-10-06 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
|
WO2018045110A1
(en)
|
2016-08-30 |
2018-03-08 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
|
MY194994A
(en)
*
|
2016-09-29 |
2022-12-30 |
Beijing Hanmi Pharmaceutical Co Ltd |
Heterodimeric immunoglobulin constructs and preparation methods thereof
|
|
US10882918B2
(en)
|
2016-09-30 |
2021-01-05 |
Hoffmann-La Roche Inc. |
Bispecific T cell activating antigen binding molecules
|
|
JP6785372B2
(ja)
|
2016-09-30 |
2020-11-18 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
多重特異性分子の機能分析のためのｓｐｒに基づく二重結合アッセイ
|
|
AU2017338915B2
(en)
|
2016-10-05 |
2024-11-21 |
Acceleron Pharma Inc. |
TGF-beta superfamily type I and type II receptor heteromultimers and uses thereof
|
|
CA3040504A1
(en)
|
2016-10-14 |
2018-04-19 |
Xencor, Inc. |
Il15/il15ra heterodimeric fc-fusion proteins
|
|
JOP20190097A1
(ar)
|
2016-10-27 |
2019-04-28 |
Janssen Pharmaceutica Nv |
الجلوبولينات المناعية واستخداماتها
|
|
CA3041988A1
(en)
|
2016-11-01 |
2018-05-11 |
Genmab B.V. |
Polypeptide variants and uses thereof
|
|
KR20190074300A
(ko)
|
2016-11-15 |
2019-06-27 |
제넨테크, 인크. |
항-cd20/항-cd3 이중특이적 항체에 의한 치료를 위한 투약
|
|
PE20191080A1
(es)
|
2016-11-18 |
2019-08-20 |
Beijing Hanmi Pharmaceutical Co Ltd |
Anticuerpo biespecifico heterodimerico estructural de anticuerpo natural anti-pd-1/anti-her2 y metodo para preparar el mismo
|
|
TW201829463A
(zh)
|
2016-11-18 |
2018-08-16 |
瑞士商赫孚孟拉羅股份公司 |
抗hla-g抗體及其用途
|
|
BR112019012950A2
(pt)
|
2016-12-23 |
2019-11-26 |
Macrogenics Inc |
molécula de ligação a adam9, composição farmacêutica, uso da molécula de ligação a adam9 e método para tratar uma doença ou condição associada ou caracterizada pela expressão de adam9 em um indivíduo
|
|
CN110650748B
(zh)
|
2017-01-06 |
2024-01-02 |
动量制药公司 |
与经工程改造的Fc构建体相关的组合物和方法
|
|
US11111305B2
(en)
|
2017-01-09 |
2021-09-07 |
Torch Therapeutics |
Method of using a bispecific antibody to conditionally inhibit a receptor signaling complex
|
|
BR112019013648A2
(pt)
*
|
2017-02-02 |
2020-01-21 |
Merck Patent Gmbh |
emparelhamento preferido de domínios de anticorpos
|
|
DK3579848T3
(da)
|
2017-02-08 |
2025-01-20 |
Dragonfly Therapeutics Inc |
Multispecifikke bindende proteiner til aktivering af naturlige dræberceller og terapeutiske anvendelser heraf til behandling af kræft
|
|
JP7577446B2
(ja)
|
2017-02-10 |
2024-11-05 |
ジェンマブ ビー．ブイ． |
ポリペプチドバリアントおよびそれらの使用
|
|
US20200291089A1
(en)
|
2017-02-16 |
2020-09-17 |
Elstar Therapeutics, Inc. |
Multifunctional molecules comprising a trimeric ligand and uses thereof
|
|
RS63818B1
(sr)
|
2017-02-17 |
2023-01-31 |
Denali Therapeutics Inc |
Konstruisani polipeptidi za vezivanje za receptor transferina
|
|
KR20240060739A
(ko)
|
2017-02-20 |
2024-05-08 |
드래곤플라이 쎄라퓨틱스, 인크. |
Her2, nkg2d 및 cd16에 결합하는 단백질
|
|
JP7556687B2
(ja)
|
2017-02-24 |
2024-09-26 |
中外製薬株式会社 |
薬学的組成物、抗原結合分子、治療方法、およびスクリーニング方法
|
|
JP7286543B2
(ja)
*
|
2017-02-27 |
2023-06-05 |
ドラゴンフライ セラピューティクス， インコーポレイテッド |
Ｃｅａを標的にする多重特異性結合タンパク質
|
|
US20200239579A1
(en)
|
2017-03-09 |
2020-07-30 |
Genmab A/S |
Antibodies against pd-l1
|
|
RU2750721C2
(ru)
|
2017-03-10 |
2021-07-01 |
Ф. Хоффманн-Ля Рош Аг |
Способ получения мультиспецифических антител
|
|
CN110520436A
(zh)
|
2017-03-15 |
2019-11-29 |
潘迪恩治疗公司 |
靶向免疫耐受性
|
|
AU2018242227B2
(en)
|
2017-03-31 |
2025-04-10 |
Genmab Holding B.V. |
Bispecific anti-CD37 antibodies, monoclonal anti-CD37 antibodies and methods of use thereof
|
|
US11780925B2
(en)
|
2017-03-31 |
2023-10-10 |
Merus N.V. |
ErbB-2 and ErbB3 binding bispecific antibodies for use in the treatment of cells that have an NRG1 fusion gene
|
|
WO2018177324A1
(zh)
*
|
2017-04-01 |
2018-10-04 |
北京韩美药品有限公司 |
抗pd‐l1/抗pd‐1天然抗体结构样异源二聚体形式双特异抗体及其制备
|
|
CN110382525B
(zh)
|
2017-04-03 |
2023-10-20 |
豪夫迈·罗氏有限公司 |
免疫缀合物
|
|
AU2018247767B2
(en)
|
2017-04-03 |
2025-01-30 |
F. Hoffmann-La Roche Ag |
Antibodies binding to STEAP-1
|
|
EP3606946B1
(en)
|
2017-04-03 |
2022-08-24 |
F. Hoffmann-La Roche AG |
Immunoconjugates of an anti-pd-1 antibody with a mutant il-2 or with il-15
|
|
EP4516809A2
(en)
|
2017-04-05 |
2025-03-05 |
F. Hoffmann-La Roche AG |
Bispecific antibodies specifically binding to pd1 and lag3
|
|
JOP20190222A1
(ar)
|
2017-04-11 |
2019-09-24 |
Zymeworks Inc |
الأجسام المضادة ثنائية النوعية المضادة لـ pd-l1 والمضادة لـ tim-3
|
|
US11866507B2
(en)
|
2017-04-11 |
2024-01-09 |
Inhibrx, Inc. |
Multispecific polypeptide constructs having constrained CD3 binding and methods of using the same
|
|
EP3609537A1
(en)
|
2017-04-13 |
2020-02-19 |
H. Hoffnabb-La Roche Ag |
An interleukin-2 immunoconjugate, a cd40 agonist, and optionally a pd-1 axis binding antagonist for use in methods of treating cancer
|
|
US12195551B2
(en)
|
2017-05-17 |
2025-01-14 |
Merus N.V. |
Combination of an ErbB-2/ErbB-3 bispecific antibody with endocrine therapy for breast cancer
|
|
CN111010866A
(zh)
|
2017-05-24 |
2020-04-14 |
潘迪恩治疗公司 |
靶向免疫耐受性
|
|
WO2018222901A1
(en)
|
2017-05-31 |
2018-12-06 |
Elstar Therapeutics, Inc. |
Multispecific molecules that bind to myeloproliferative leukemia (mpl) protein and uses thereof
|
|
KR20200014304A
(ko)
|
2017-06-02 |
2020-02-10 |
에프. 호프만-라 로슈 아게 |
암의 치료를 위한 제ii형 항-cd20 항체 및 항-cd20/항-cd3 이중특이적 항체
|
|
KR102692379B1
(ko)
|
2017-06-05 |
2024-08-05 |
얀센 바이오테크 인코포레이티드 |
Pd-1과 특이적으로 결합하는 항체 및 사용 방법
|
|
AU2018281045A1
(en)
|
2017-06-05 |
2019-12-12 |
Janssen Biotech, Inc. |
Engineered multispecific antibodies and other multimeric proteins with asymmetrical CH2-CH3 region mutations
|
|
MA49259A
(fr)
|
2017-06-07 |
2020-04-15 |
Genmab Bv |
Anticorps thérapeutiques à base d'hexamères d'igg mutées
|
|
US11845806B2
(en)
|
2017-06-14 |
2023-12-19 |
Dingfu Biotarget Co., Ltd. |
Proteinaceous heterodimer and use thereof
|
|
EP3645575A4
(en)
|
2017-06-30 |
2021-03-24 |
Zymeworks Inc. |
STABILIZED CHEMERICAL FABS
|
|
CA3067603A1
(en)
|
2017-06-30 |
2019-01-03 |
Xencor, Inc. |
Targeted heterodimeric fc fusion proteins containing il-15/il-15ra and antigen binding domains
|
|
AR112603A1
(es)
|
2017-07-10 |
2019-11-20 |
Lilly Co Eli |
Anticuerpos biespecíficos inhibidores de punto de control
|
|
WO2019025545A1
(en)
|
2017-08-04 |
2019-02-07 |
Genmab A/S |
BINDING AGENTS BINDING TO PD-L1 AND CD137 AND THEIR USE
|
|
JP2020530028A
(ja)
|
2017-08-09 |
2020-10-15 |
メルス ナムローゼ フェンノートシャップ |
ＥＧＦＲ及びｃＭＥＴに結合する抗体
|
|
WO2019035938A1
(en)
|
2017-08-16 |
2019-02-21 |
Elstar Therapeutics, Inc. |
MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF
|
|
BR112020003670A2
(pt)
|
2017-08-22 |
2020-09-01 |
Sanabio, Llc |
receptores de interferon solúveis e usos dos mesmos
|
|
US11987609B2
(en)
*
|
2017-09-25 |
2024-05-21 |
Dingfu Biotarget Co., Ltd. |
Proteinaceous heterodimer and use thereof
|
|
AU2018353420A1
(en)
|
2017-10-20 |
2020-04-16 |
F. Hoffmann-La Roche Ag |
Method for generating multispecific antibodies from monospecific antibodies
|
|
CN111372947A
(zh)
|
2017-10-30 |
2020-07-03 |
豪夫迈·罗氏有限公司 |
在体内从单特异性抗体产生多特异性抗体的方法
|
|
IL272747B2
(en)
|
2017-11-01 |
2025-04-01 |
Hoffmann La Roche |
Bispecific antibodies 1 + 2
|
|
CN111295392A
(zh)
|
2017-11-01 |
2020-06-16 |
豪夫迈·罗氏有限公司 |
Compbody–多价靶结合物
|
|
CA3079129C
(en)
|
2017-11-01 |
2023-02-28 |
F. Hoffmann-La Roche Ag |
Trifab-contorsbody
|
|
JP2021500902A
(ja)
|
2017-11-01 |
2021-01-14 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
新規ｔｎｆファミリーリガンド三量体含有抗原結合分子
|
|
CN112272563A
(zh)
|
2017-11-08 |
2021-01-26 |
Xencor股份有限公司 |
使用新颖抗pd-1序列的双特异性和单特异性抗体
|
|
US10981992B2
(en)
|
2017-11-08 |
2021-04-20 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
|
AU2018378529A1
(en)
|
2017-12-04 |
2020-06-18 |
Beijing Hanmi Pharmaceutical Co., Ltd. |
Anti-PD-L1/anti-CD47 bispecific antibody with structure like natural antibody and in form of heterodimer and preparation thereof
|
|
TW201938194A
(zh)
|
2017-12-05 |
2019-10-01 |
日商中外製藥股份有限公司 |
包含結合cd3及cd137的改變的抗體可變區之抗原結合分子
|
|
US10174091B1
(en)
|
2017-12-06 |
2019-01-08 |
Pandion Therapeutics, Inc. |
IL-2 muteins
|
|
US10946068B2
(en)
|
2017-12-06 |
2021-03-16 |
Pandion Operations, Inc. |
IL-2 muteins and uses thereof
|
|
CN111465618A
(zh)
|
2017-12-12 |
2020-07-28 |
宏观基因有限公司 |
双特异性cd16-结合分子及其在疾病治疗中的用途
|
|
US12006368B2
(en)
|
2017-12-19 |
2024-06-11 |
Surrozen Operating, Inc. |
Anti-frizzled antibodies and methods of use
|
|
MX2020006322A
(es)
|
2017-12-19 |
2020-09-18 |
Xencor Inc |
Proteinas de fusion il-2 fc modificadas.
|
|
EP3732201A4
(en)
|
2017-12-19 |
2022-04-20 |
Surrozen Operating, Inc. |
WNT SURROGATES AND THEIR USES
|
|
CA3085785A1
(en)
|
2017-12-19 |
2019-06-27 |
Surrozen, Inc. |
Anti-lrp5/6 antibodies and methods of use
|
|
KR102575787B1
(ko)
|
2017-12-21 |
2023-09-08 |
에프. 호프만-라 로슈 아게 |
Hla-a2/wt1에 결합하는 항체
|
|
WO2019122054A1
(en)
|
2017-12-22 |
2019-06-27 |
F. Hoffmann-La Roche Ag |
Depletion of light chain mispaired antibody variants by hydrophobic interaction chromatography
|
|
JP7314146B2
(ja)
|
2017-12-28 |
2023-07-25 |
中外製薬株式会社 |
細胞傷害誘導治療剤
|
|
EP3737692A4
(en)
|
2018-01-09 |
2021-09-29 |
Elstar Therapeutics, Inc. |
CALRETICULIN AND MODIFIED T-LYMPHOCYTES BINDING CONSTRUCTIONS FOR THE TREATMENT OF DISEASES
|
|
US20210107988A1
(en)
|
2018-01-24 |
2021-04-15 |
Genmab B.V. |
Polypeptide variants and uses thereof
|
|
WO2019148410A1
(en)
|
2018-02-01 |
2019-08-08 |
Merck Sharp & Dohme Corp. |
Anti-pd-1 antibodies
|
|
WO2019148412A1
(en)
|
2018-02-01 |
2019-08-08 |
Merck Sharp & Dohme Corp. |
Anti-pd-1/lag3 bispecific antibodies
|
|
CN119733046A
(zh)
|
2018-02-06 |
2025-04-01 |
豪夫迈·罗氏有限公司 |
眼科疾病的治疗
|
|
CA3090244A1
(en)
|
2018-02-08 |
2019-08-15 |
Dragonfly Therapeutics, Inc. |
Antibody variable domains targeting the nkg2d receptor
|
|
WO2019153200A1
(zh)
*
|
2018-02-08 |
2019-08-15 |
北京韩美药品有限公司 |
抗pd-1/抗her2天然抗体结构样异源二聚体形式双特异抗体及其制备
|
|
AU2019218959A1
(en)
|
2018-02-08 |
2020-09-03 |
Genentech, Inc. |
Bispecific antigen-binding molecules and methods of use
|
|
JP7407118B2
(ja)
|
2018-02-08 |
2023-12-28 |
アムジェン インコーポレイテッド |
低ｐＨ医薬抗体製剤
|
|
TWI829667B
(zh)
|
2018-02-09 |
2024-01-21 |
瑞士商赫孚孟拉羅股份公司 |
結合gprc5d之抗體
|
|
KR20200120927A
(ko)
*
|
2018-02-11 |
2020-10-22 |
베이징 한미 파마슈티컬 컴퍼니 리미티드 |
항-pd-1/항-vegf 천연 항체 구조-유사 이형이량체형 이중특이성 항체 및 그의 제조
|
|
WO2019160007A1
(ja)
|
2018-02-14 |
2019-08-22 |
中外製薬株式会社 |
抗原結合分子および組合せ
|
|
MX2020008489A
(es)
|
2018-02-15 |
2020-09-25 |
Macrogenics Inc |
Dominios de union a cd3 variantes y su uso en terapias de combinacion para el tratamiento de enfermedades.
|
|
WO2019164930A1
(en)
|
2018-02-20 |
2019-08-29 |
Dragonfly Therapeutics, Inc. |
Multi-specific binding proteins that bind cd33, nkg2d, and cd16, and methods of use
|
|
EP3765493A2
(en)
|
2018-03-12 |
2021-01-20 |
Genmab A/S |
Antibodies
|
|
US20210260210A1
(en)
|
2018-03-13 |
2021-08-26 |
Zymeworks Inc. |
Anti-her2 biparatopic antibody-drug conjugates and methods of use
|
|
WO2019178362A1
(en)
|
2018-03-14 |
2019-09-19 |
Elstar Therapeutics, Inc. |
Multifunctional molecules that bind to calreticulin and uses thereof
|
|
US20210009711A1
(en)
|
2018-03-14 |
2021-01-14 |
Elstar Therapeutics, Inc. |
Multifunctional molecules and uses thereof
|
|
US10982006B2
(en)
|
2018-04-04 |
2021-04-20 |
Xencor, Inc. |
Heterodimeric antibodies that bind fibroblast activation protein
|
|
CN111954537A
(zh)
|
2018-04-09 |
2020-11-17 |
美国安进公司 |
生长分化因子15融合蛋白
|
|
JP2021520812A
(ja)
|
2018-04-11 |
2021-08-26 |
インヒブルクス インコーポレイテッド |
制約されたｃｄ３結合を有する多重特異性ポリペプチド構築物ならびに関連する方法および使用
|
|
MA52289A
(fr)
|
2018-04-18 |
2021-02-24 |
Xencor Inc |
Protéines de fusion fc hétérodimères il-15/il-15ra et leurs utilisations
|
|
SG11202010163QA
(en)
|
2018-04-18 |
2020-11-27 |
Xencor Inc |
Pd-1 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and pd-1 antigen binding domains and uses thereof
|
|
CA3097649A1
(en)
|
2018-04-18 |
2019-10-24 |
Xencor, Inc. |
Lag-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and lag-3 antigen binding domains
|
|
AR114789A1
(es)
|
2018-04-18 |
2020-10-14 |
Hoffmann La Roche |
Anticuerpos anti-hla-g y uso de los mismos
|
|
WO2019204655A1
(en)
|
2018-04-18 |
2019-10-24 |
Xencor, Inc. |
Tim-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and tim-3 antigen binding domains
|
|
AR115052A1
(es)
|
2018-04-18 |
2020-11-25 |
Hoffmann La Roche |
Anticuerpos multiespecíficos y utilización de los mismos
|
|
MX2020011552A
(es)
|
2018-05-03 |
2020-11-24 |
Genmab Bv |
Combinaciones de variantes de anticuerpos y usos de las mismas.
|
|
CN113164588A
(zh)
|
2018-05-16 |
2021-07-23 |
詹森生物科技公司 |
治疗癌症并增强t细胞重定向治疗剂的功效的方法
|
|
JOP20190116A1
(ar)
|
2018-05-24 |
2019-11-24 |
Janssen Biotech Inc |
الأجسام المضادة لتكتل التمايز 33 (cd33)، والأجسام المضادة ثنائية النوعية لتكتل التمايز 33 (cd33)/تكتل التمايز 3 (cd3) واستخداماتها
|
|
CA3101304A1
(en)
|
2018-05-24 |
2019-11-28 |
Janssen Biotech, Inc. |
Monospecific and multispecific anti-tmeff2 antibodies and their uses
|
|
LT3802608T
(lt)
|
2018-05-24 |
2025-06-25 |
Janssen Biotech, Inc. |
Antikūnai prieš cd3 ir jų panaudojimas
|
|
CR20200563A
(es)
|
2018-05-24 |
2021-05-11 |
Janssen Biotech Inc |
Agentes aglutinantes de psma y usos de estos
|
|
EP3802611A2
(en)
|
2018-06-01 |
2021-04-14 |
Novartis AG |
Binding molecules against bcma and uses thereof
|
|
CA3101019A1
(en)
|
2018-06-01 |
2019-12-05 |
Compugen Ltd |
Anti-pvrig/anti-tigit bispecific antibodies and methods of use
|
|
WO2019244107A1
(en)
|
2018-06-21 |
2019-12-26 |
Daiichi Sankyo Company, Limited |
Compositions including cd3 antigen binding fragments and uses thereof
|
|
US12275797B2
(en)
|
2018-06-22 |
2025-04-15 |
Genmab Holding B.V. |
Anti-CD37 antibodies and anti-CD20 antibodies, compositions and methods of use thereof
|
|
TWI851585B
(zh)
|
2018-07-02 |
2024-08-11 |
美商安進公司 |
抗steap1抗原結合蛋白
|
|
EP3818083A2
(en)
|
2018-07-03 |
2021-05-12 |
Elstar Therapeutics, Inc. |
Anti-tcr antibody molecules and uses thereof
|
|
EP3820890A1
(en)
|
2018-07-13 |
2021-05-19 |
Genmab A/S |
Trogocytosis-mediated therapy using cd38 antibodies
|
|
MX2020013631A
(es)
|
2018-07-13 |
2021-03-25 |
Genmab As |
Variantes de anticuerpo grupo de diferenciacion (cd38) y usos de las mismas.
|
|
WO2020018556A1
(en)
|
2018-07-16 |
2020-01-23 |
Amgen Inc. |
Method of treating multiple myeloma
|
|
US12195533B2
(en)
|
2018-07-24 |
2025-01-14 |
Inhibrx Biosciences, Inc. |
Multispecific polypeptide constructs containing a constrained CD3 binding domain and a receptor binding region and methods of using the same
|
|
EA202091888A1
(ru)
|
2018-08-08 |
2020-10-23 |
Драгонфлай Терапьютикс, Инк. |
Вариабельные домены антител, нацеленные на рецептор nkg2d
|
|
EP3845558A4
(en)
|
2018-08-29 |
2022-05-18 |
Chugai Seiyaku Kabushiki Kaisha |
ANTIBODY HALF-MOLECULE AND METHODS FOR INHIBITION OF HOMODIMER FORMATION OF ANTIBODY HALF-MOLECULE
|
|
CN113195523A
(zh)
|
2018-10-03 |
2021-07-30 |
Xencor股份有限公司 |
IL-12异源二聚体Fc融合蛋白
|
|
AU2019354105A1
(en)
|
2018-10-04 |
2021-04-29 |
Genmab Holding B.V. |
Pharmaceutical compositions comprising bispecific anti-CD37 antibodies
|
|
JP2022504802A
(ja)
|
2018-10-11 |
2022-01-13 |
インヒブルクス インコーポレイテッド |
５ｔ４シングルドメイン抗体およびその治療組成物
|
|
US20230124851A1
(en)
|
2018-10-11 |
2023-04-20 |
Inhibrx, lnc. |
B7h3 single domain antibodies and therapeutic compositions thereof
|
|
WO2020077257A1
(en)
|
2018-10-11 |
2020-04-16 |
Inhibrx, Inc. |
Pd-1 single domain antibodies and therapeutic compositions thereof
|
|
CN113166263A
(zh)
|
2018-10-11 |
2021-07-23 |
印希比股份有限公司 |
Dll3单域抗体及其治疗性组合物
|
|
US11377477B2
(en)
|
2018-10-12 |
2022-07-05 |
Xencor, Inc. |
PD-1 targeted IL-15/IL-15RALPHA fc fusion proteins and uses in combination therapies thereof
|
|
MX2021004711A
(es)
|
2018-10-23 |
2021-07-02 |
Dragonfly Therapeutics Inc |
Proteinas heterodimericas fusionadas con fragmento cristalizable (fc).
|
|
CN119033685A
(zh)
|
2018-10-29 |
2024-11-29 |
豪夫迈·罗氏有限公司 |
抗体制剂
|
|
WO2020093990A1
(zh)
*
|
2018-11-05 |
2020-05-14 |
北京韩美药品有限公司 |
抗TNFα/抗IL‐17A天然抗体结构样异源二聚体形式双特异抗体及其制备
|
|
AU2019375014A1
(en)
|
2018-11-06 |
2021-05-27 |
BioNTech SE |
Antibody formulation
|
|
AU2019387482A1
(en)
*
|
2018-11-30 |
2021-06-17 |
Memorial Sloan Kettering Cancer Center |
Heterodimeric tetravalency and specificity antibody compositions and uses thereof
|
|
JP2022513708A
(ja)
|
2018-12-05 |
2022-02-09 |
モルフォシス・アーゲー |
多重特異性抗原結合分子
|
|
EP3897853A1
(en)
|
2018-12-20 |
2021-10-27 |
Xencor, Inc. |
Targeted heterodimeric fc fusion proteins containing il-15/il-15ra and nkg2d antigen binding domains
|
|
AU2019410075B2
(en)
|
2018-12-21 |
2022-08-25 |
F. Hoffmann-La Roche Ag |
Antibodies binding to CD3
|
|
BR112021012337A2
(pt)
|
2018-12-24 |
2021-09-14 |
Sanofi |
Proteínas de ligação multiespecíficas baseadas em pseudofab
|
|
CN113412123A
(zh)
|
2018-12-28 |
2021-09-17 |
豪夫迈·罗氏有限公司 |
用于免疫应答增强的患者的治疗性用途的肽-mhc-i-抗体融合蛋白
|
|
CA3124352A1
(en)
|
2019-01-04 |
2020-07-09 |
Resolve Therapeutics, Llc |
Treatment of sjogren's disease with nuclease fusion proteins
|
|
TWI852977B
(zh)
|
2019-01-10 |
2024-08-21 |
美商健生生物科技公司 |
前列腺新抗原及其用途
|
|
US20220153827A1
(en)
|
2019-01-15 |
2022-05-19 |
Janssen Biotech, Inc. |
Anti-TNF Antibody Compositions and Methods for the Treatment of Juvenile Idiopathic Arthritis
|
|
AU2020209257A1
(en)
|
2019-01-18 |
2021-08-05 |
Janssen Biotech, Inc. |
GPRC5D chimeric antigen receptors and cells expressing the same
|
|
US20220064278A1
(en)
|
2019-01-23 |
2022-03-03 |
Janssen Biotech, Inc. |
Anti-TNF Antibody Compositions for Use in Methods for the Treatment of Psoriatic Arthritis
|
|
CN114026122B
(zh)
|
2019-02-21 |
2024-12-31 |
马伦戈治疗公司 |
结合t细胞相关癌细胞的多功能分子及其用途
|
|
CN114126714A
(zh)
|
2019-02-21 |
2022-03-01 |
马伦戈治疗公司 |
抗tcr抗体分子及其用途
|
|
US12006345B2
(en)
|
2019-02-21 |
2024-06-11 |
Xencor, Inc. |
Untargeted and targeted IL-10 Fc-fusion proteins
|
|
WO2020172601A1
(en)
|
2019-02-21 |
2020-08-27 |
Elstar Therapeutics, Inc. |
Multifunctional molecules that bind to calreticulin and uses thereof
|
|
JP7579795B2
(ja)
|
2019-02-21 |
2024-11-08 |
マレンゴ・セラピューティクス，インコーポレーテッド |
ＮＫｐ３０に結合する抗体分子およびその使用
|
|
WO2020172598A1
(en)
|
2019-02-21 |
2020-08-27 |
Elstar Therapeutics, Inc. |
Multifunctional molecules that bind to t cells and uses thereof to treat autoimmune disorders
|
|
WO2020174370A2
(en)
|
2019-02-26 |
2020-09-03 |
Janssen Biotech, Inc. |
Combination therapies and patient stratification with bispecific anti-egfr/c-met antibodies
|
|
CN120230213A
(zh)
|
2019-03-01 |
2025-07-01 |
Xencor股份有限公司 |
结合enpp3和cd3的异二聚抗体
|
|
MX2021010857A
(es)
|
2019-03-11 |
2021-12-15 |
Janssen Biotech Inc |
Anticuerpos biespecificos anti-v(beta17)/anti-cd123.
|
|
MA55282A
(fr)
|
2019-03-14 |
2022-01-19 |
Janssen Biotech Inc |
Procédés de fabrication pour la production de compositions d'anticorps anti-tnf
|
|
CN113825765A
(zh)
|
2019-03-14 |
2021-12-21 |
詹森生物科技公司 |
用于制备抗il12/il23抗体组合物的制造方法
|
|
JP7662529B2
(ja)
|
2019-03-14 |
2025-04-15 |
ヤンセン バイオテツク，インコーポレーテツド |
抗ｔｎｆ抗体組成物を産生するための方法
|
|
MA55283A
(fr)
|
2019-03-14 |
2022-01-19 |
Janssen Biotech Inc |
Procédés de production de compositions d'anticorps anti-tnf
|
|
WO2020198683A1
(en)
*
|
2019-03-28 |
2020-10-01 |
Ab Studio Inc. |
Heteromultimeric proteins and methods of use thereof
|
|
CN113677701B
(zh)
|
2019-03-29 |
2025-02-07 |
豪夫迈·罗氏有限公司 |
产生亲合结合多特异性抗体的方法
|
|
WO2020200941A1
(en)
|
2019-03-29 |
2020-10-08 |
F. Hoffmann-La Roche Ag |
Spr-based binding assay for the functional analysis of multivalent molecules
|
|
BR112021020859A2
(pt)
|
2019-04-25 |
2022-01-04 |
Hoffmann La Roche |
Conjuntos de polipeptídeos, método para gerar um polipeptídeo, polipeptídeo heterodimérico, primeiro polipeptídeo precursor heterodimérico e segundo polipeptídeo precursor heterodimérico
|
|
TW202106713A
(zh)
|
2019-04-25 |
2021-02-16 |
瑞士商赫孚孟拉羅股份公司 |
具延長半衰期之可活化治療性多特異性多肽
|
|
BR112021020843A2
(pt)
*
|
2019-04-25 |
2022-02-01 |
Hoffmann La Roche |
Conjunto de polipeptídeos precursores heterodiméricos, polipeptídeos heterodiméricos, métodos para gerar um polipeptídeo heterodimérico e para identificar um polipeptídeo heterodimérico multiespecífico, polipeptídeo heterodimérico multiespecífico, primeiro e segundo polipeptídeo precursor heterodimérico
|
|
MX2021013532A
(es)
|
2019-05-08 |
2022-02-11 |
Janssen Biotech Inc |
Materiales y metodos para modular la inmunidad mediada por celulas t.
|
|
WO2020225456A1
(en)
|
2019-05-09 |
2020-11-12 |
Genmab B.V. |
Dosage regimens for a combination of anti-dr5 antibodies for use in treating cancer
|
|
JP7273195B2
(ja)
|
2019-05-13 |
2023-05-12 |
エフ． ホフマン－ラ ロシュ アーゲー |
干渉抑制薬物動態イムノアッセイ
|
|
US11879013B2
(en)
|
2019-05-14 |
2024-01-23 |
Janssen Biotech, Inc. |
Combination therapies with bispecific anti-EGFR/c-Met antibodies and third generation EGFR tyrosine kinase inhibitors
|
|
CN114144428B
(zh)
*
|
2019-05-14 |
2025-01-21 |
普罗根有限公司 |
修饰的免疫球蛋白fc融合蛋白及其用途
|
|
WO2020236655A1
(en)
|
2019-05-17 |
2020-11-26 |
Xencor, Inc. |
Il-7-fc-fusi0n proteins
|
|
TW202110885A
(zh)
|
2019-05-20 |
2021-03-16 |
美商潘迪恩治療公司 |
靶向ＭＡｄＣＡＭ之免疫耐受性
|
|
JP7664183B2
(ja)
|
2019-05-21 |
2025-04-17 |
ノバルティス アーゲー |
Ｂｃｍａに対する三重特異性結合分子及びその使用
|
|
WO2020236797A1
(en)
|
2019-05-21 |
2020-11-26 |
Novartis Ag |
Variant cd58 domains and uses thereof
|
|
CR20210576A
(es)
|
2019-05-21 |
2021-12-15 |
Novartis Ag |
Moléculas de unión a cd19 y usos de las mismas
|
|
MA56015A
(fr)
|
2019-06-03 |
2022-04-06 |
Janssen Biotech Inc |
Compositions d'anticorps anti-tnf et méthodes pour le traitement de l'arthrite psoriasique
|
|
TW202112808A
(zh)
|
2019-06-05 |
2021-04-01 |
日商中外製藥股份有限公司 |
抗體切斷部位結合分子
|
|
MX2021015536A
(es)
|
2019-06-19 |
2022-02-10 |
Hoffmann La Roche |
Metodo para la generacion de una celula que expresa proteina mediante integracion dirigida usando acido ribonucleico mensajero (arnm) de cre.
|
|
BR112021026286A2
(pt)
|
2019-06-26 |
2022-03-03 |
Hoffmann La Roche |
Método para aumentar o título de polipeptídeo heterólogo e/ou reduzir a produção de lactato de uma célula de mamífero recombinante e métodos para produzir um polipeptídeo heterólogo e uma célula de mamífero recombinante
|
|
WO2021001458A1
(en)
|
2019-07-01 |
2021-01-07 |
Tonix Pharma Holdings Limited |
Anti-cd154 antibodies and uses thereof
|
|
TW202115115A
(zh)
|
2019-07-02 |
2021-04-16 |
瑞士商赫孚孟拉羅股份公司 |
免疫結合物
|
|
MX2022000111A
(es)
|
2019-07-10 |
2022-02-10 |
Chugai Pharmaceutical Co Ltd |
Moleculas de union a claudina-6 y usos de las mismas.
|
|
CN112210005B
(zh)
*
|
2019-07-11 |
2024-03-26 |
京天成生物技术(北京)有限公司 |
低免疫原性低adcc/cdc功能的抗c5人源化单抗及其应用
|
|
US20220275069A1
(en)
|
2019-07-12 |
2022-09-01 |
Janssen Pharmaceutica Nv |
Binding agents and uses thereof
|
|
AR119393A1
(es)
|
2019-07-15 |
2021-12-15 |
Hoffmann La Roche |
Anticuerpos que se unen a nkg2d
|
|
JP2022541332A
(ja)
|
2019-07-26 |
2022-09-22 |
ヤンセン バイオテツク，インコーポレーテツド |
カリクレイン関連ペプチダーゼ２抗原結合ドメインを含むタンパク質及びその使用
|
|
MX2022001156A
(es)
|
2019-07-31 |
2022-02-22 |
Hoffmann La Roche |
Anticuerpos que se fijan a gprc5d.
|
|
JP2022543551A
(ja)
|
2019-07-31 |
2022-10-13 |
エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト |
Ｇｐｒｃ５ｄに結合する抗体
|
|
US20210102002A1
(en)
|
2019-08-06 |
2021-04-08 |
Xencor, Inc. |
HETERODIMERIC IgG-LIKE BISPECIFIC ANTIBODIES
|
|
CR20220054A
(es)
|
2019-08-15 |
2022-06-06 |
Janssen Biotech Inc |
Materiales y métodos para fragmentos variables de cadena única mejorado
|
|
US11851466B2
(en)
|
2019-10-03 |
2023-12-26 |
Xencor, Inc. |
Targeted IL-12 heterodimeric Fc-fusion proteins
|
|
TW202128757A
(zh)
|
2019-10-11 |
2021-08-01 |
美商建南德克公司 |
具有改善之特性的 PD-1 標靶 IL-15/IL-15Rα FC 融合蛋白
|
|
JP2023500701A
(ja)
|
2019-11-06 |
2023-01-10 |
ジェンマブ ビー．ブイ． |
抗体変種の組み合わせおよびその使用
|
|
KR20220114560A
(ko)
|
2019-11-18 |
2022-08-17 |
얀센 바이오테크 인코포레이티드 |
항-cd79 키메라 항원 수용체, car-t 세포 및 이의 용도
|
|
US12076400B2
(en)
|
2019-12-06 |
2024-09-03 |
Zymeworks Bc Inc. |
Methods of using a bispecific antigen-binding construct targeting HER2 in combination with CDK4/6 inhibitors for the treatment of breast cancer
|
|
CN115087670A
(zh)
|
2019-12-11 |
2022-09-20 |
西拉格国际有限责任公司 |
包含ltbr和edb结合结构域的多特异性结合分子及其用途
|
|
KR20220113790A
(ko)
|
2019-12-13 |
2022-08-16 |
제넨테크, 인크. |
항-ly6g6d 항체 및 사용 방법
|
|
TW202136287A
(zh)
|
2019-12-17 |
2021-10-01 |
法商Ｏｓｅ免疫治療公司 |
包含il-7變體之雙官能分子
|
|
BR112022012010A2
(pt)
|
2019-12-18 |
2022-08-30 |
Hoffmann La Roche |
Anticorpos, ácido nucleico isolado, célula hospedeira, formulação farmacêutica, uso do anticorpo, método de produção de um anticorpo, método de tratamento de um indivíduo que tem câncer e método de tratamento de um indivíduo que tem uma doença inflamatória ou autoimune
|
|
BR112022011854A2
(pt)
|
2019-12-18 |
2022-09-06 |
Hoffmann La Roche |
Anticorpos, polinucleotídeo isolado, célula hospedeira, métodos para produzir um anticorpo e para tratar uma doença, composição farmacêutica, usos do anticorpo e invenção
|
|
GB201919062D0
(en)
|
2019-12-20 |
2020-02-05 |
Ucb Biopharma Sprl |
Antibody
|
|
GB201919061D0
(en)
|
2019-12-20 |
2020-02-05 |
Ucb Biopharma Sprl |
Multi-specific antibody
|
|
JP2023508439A
(ja)
|
2019-12-23 |
2023-03-02 |
ソテリア・バイオセラピューティクス・インコーポレイテッド |
治療ｆｃ組成物の化学誘導会合および解離ならびにｔ細胞エンゲージャーとヒト血清アルブミンとの化学誘導二量体形成
|
|
AU2019479791B2
(en)
|
2019-12-27 |
2024-05-02 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-CTLA-4 antibody and use thereof
|
|
CN114930170A
(zh)
|
2020-01-02 |
2022-08-19 |
豪夫迈·罗氏有限公司 |
用于测定脑中的治疗性抗体量的方法
|
|
WO2021138407A2
(en)
|
2020-01-03 |
2021-07-08 |
Marengo Therapeutics, Inc. |
Multifunctional molecules that bind to cd33 and uses thereof
|
|
KR20220130724A
(ko)
|
2020-01-16 |
2022-09-27 |
젠맵 에이/에스 |
Cd38 항체의 제제 및 그의 용도
|
|
KR20220148175A
(ko)
|
2020-01-29 |
2022-11-04 |
인히브릭스, 인크. |
Ｃｄ28 단일 도메인 항체 및 이의 다가 및 다중특이적 구조체
|
|
EP4096707A1
(en)
|
2020-01-30 |
2022-12-07 |
Umoja Biopharma, Inc. |
Bispecific transduction enhancer
|
|
GB202001447D0
(en)
|
2020-02-03 |
2020-03-18 |
Ucb Biopharma Sprl |
Antibodies
|
|
WO2021155916A1
(en)
|
2020-02-04 |
2021-08-12 |
BioNTech SE |
Treatment involving antigen vaccination and binding agents binding to pd-l1 and cd137
|
|
JOP20220184A1
(ar)
|
2020-02-12 |
2023-01-30 |
Janssen Biotech Inc |
علاج مصابي السرطان ممن لديهم طفرات تخطي c-Met إكسون14
|
|
TW202144388A
(zh)
|
2020-02-14 |
2021-12-01 |
美商健生生物科技公司 |
在卵巢癌中表現之新抗原及其用途
|
|
TW202144389A
(zh)
|
2020-02-14 |
2021-12-01 |
美商健生生物科技公司 |
在多發性骨髓瘤中表現之新抗原及其用途
|
|
EP4107187A4
(en)
|
2020-02-21 |
2024-07-03 |
Pandion Operations, Inc. |
TISSUE-TARGETED IMMUNOTOLERANCE WITH A CD39 EFFECTOR
|
|
BR112022018176A2
(pt)
|
2020-03-13 |
2022-12-06 |
Janssen Biotech Inc |
Materiais e métodos para ligação de siglec-3/cd33
|
|
EP4121456A1
(en)
|
2020-03-18 |
2023-01-25 |
Genmab A/S |
Antibodies binding to b7h4
|
|
JP2023520773A
(ja)
|
2020-03-27 |
2023-05-19 |
ノバルティス アーゲー |
増殖性疾患及び自己免疫疾患を治療するための二重特異性組合せ治療
|
|
CN115335410A
(zh)
|
2020-03-31 |
2022-11-11 |
中外制药株式会社 |
生产多特异性抗原结合分子的方法
|
|
AR121695A1
(es)
|
2020-03-31 |
2022-06-29 |
Chugai Pharmaceutical Co Ltd |
Moléculas de unión al antígeno multiespecíficas dirigidas a dll3 y sus usos
|
|
BR112022020629A2
(pt)
|
2020-04-15 |
2022-11-29 |
Hoffmann La Roche |
Polipeptídeo de interleucina-7 (il-7) mutante, imunoconjugado, um ou mais polinucleotídeos isolados, célula hospedeira, métodos para produzir um polipeptídeo il-7 mutante ou um imunoconjugado, para tratar uma doença e para estimular o sistema imunológico, polipeptídeo il-7 mutante, composição farmacêutica, uso do polipeptídeo il-7 mutante e invenção
|
|
JP2023522013A
(ja)
|
2020-04-16 |
2023-05-26 |
ヤンセン バイオテツク，インコーポレーテツド |
多重特異性分子の形成を監視するための逆相高速液体クロマトグラフィ（ｒｐ－ｈｐｌｃ）のためのシステム、材料、及び方法
|
|
GB202005879D0
(en)
*
|
2020-04-22 |
2020-06-03 |
Petmedix Ltd |
Heterodimeric proteins
|
|
WO2021217085A1
(en)
|
2020-04-24 |
2021-10-28 |
Marengo Therapeutics, Inc. |
Multifunctional molecules that bind to t cell related cancer cells and uses thereof
|
|
KR20230007384A
(ko)
|
2020-04-30 |
2023-01-12 |
브리스톨-마이어스 스큅 컴퍼니 |
치료 방법
|
|
US12157771B2
(en)
|
2020-05-06 |
2024-12-03 |
Dragonfly Therapeutics, Inc. |
Proteins binding NKG2D, CD16 and CLEC12A
|
|
BR112022022614A2
(pt)
|
2020-05-11 |
2023-02-07 |
Hoffmann La Roche |
Métodos para estimular uma resposta imune, melhorar uma imunoterapia, tratar uma doença, reduzir crescimento tumoral, produzir um imunoconjugado e produzir uma composição, método de vacinação, imunoconjugados, composição, usos e kits
|
|
CN116249548A
(zh)
|
2020-05-11 |
2023-06-09 |
詹森生物科技公司 |
用于治疗多发性骨髓瘤的方法
|
|
US11919956B2
(en)
|
2020-05-14 |
2024-03-05 |
Xencor, Inc. |
Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3
|
|
EP4149632A1
(en)
|
2020-05-14 |
2023-03-22 |
Xencor, Inc. |
Heterodimeric antibodies that bind msln and cd3
|
|
CA3184189A1
(en)
|
2020-05-27 |
2021-12-02 |
Janssen Biotech, Inc. |
Proteins comprising cd3 antigen binding domains and uses thereof
|
|
AU2021282817B2
(en)
*
|
2020-06-01 |
2025-07-03 |
Mustbio Co., Ltd. |
Bispecific antibody or antigen-binding fragment thereof, and preparation method therefor
|
|
CA3186143A1
(en)
|
2020-06-17 |
2021-12-23 |
Medimmune Limited |
Heterodimeric relaxin fusions and uses thereof
|
|
KR20230025783A
(ko)
|
2020-06-19 |
2023-02-23 |
에프. 호프만-라 로슈 아게 |
면역 활성화 Fc 도메인 결합 분자
|
|
PE20230835A1
(es)
|
2020-06-19 |
2023-05-19 |
Hoffmann La Roche |
Anticuerpos que se unen a cd3
|
|
WO2021255146A1
(en)
|
2020-06-19 |
2021-12-23 |
F. Hoffmann-La Roche Ag |
Antibodies binding to cd3 and cea
|
|
WO2021255143A1
(en)
|
2020-06-19 |
2021-12-23 |
F. Hoffmann-La Roche Ag |
Antibodies binding to cd3 and folr1
|
|
US11780920B2
(en)
|
2020-06-19 |
2023-10-10 |
Hoffmann-La Roche Inc. |
Antibodies binding to CD3 and CD19
|
|
WO2022006153A1
(en)
|
2020-06-29 |
2022-01-06 |
Resolve Therapeutics, Llc |
Treatment of sjogren's syndrome with nuclease fusion proteins
|
|
WO2022018294A1
(en)
|
2020-07-23 |
2022-01-27 |
Genmab B.V. |
A combination of anti-dr5 antibodies and an immunomodulatory imide drug for use in treating multiple myeloma
|
|
AR123083A1
(es)
|
2020-07-29 |
2022-10-26 |
Janssen Biotech Inc |
Proteínas que comprenden dominios de unión al antígeno hla-g y sus usos
|
|
CA3190649A1
(en)
|
2020-07-31 |
2022-02-03 |
Chugai Seiyaku Kabushiki Kaisha |
Pharmaceutical composition comprising cell expressing chimeric receptor
|
|
US20230287088A1
(en)
|
2020-08-06 |
2023-09-14 |
BioNTech SE |
Binding agents for coronavirus s protein
|
|
MX2023001962A
(es)
|
2020-08-19 |
2023-04-26 |
Xencor Inc |
Composiciones anti-cd28.
|
|
WO2022046922A2
(en)
|
2020-08-26 |
2022-03-03 |
Marengo Therapeutics, Inc. |
Antibody molecules that bind to nkp30 and uses thereof
|
|
CN116249718A
(zh)
|
2020-08-26 |
2023-06-09 |
马伦戈治疗公司 |
结合至钙网蛋白的多功能性分子及其用途
|
|
GB2616354A
(en)
|
2020-08-26 |
2023-09-06 |
Marengo Therapeutics Inc |
Methods of detecting TRBC1 or TRBC2
|
|
US20230416371A1
(en)
*
|
2020-08-28 |
2023-12-28 |
Chugai Seiyaku Kabushiki Kaisha |
Heterodimer fc polypeptide
|
|
JP2023539525A
(ja)
|
2020-09-02 |
2023-09-14 |
ジェンマブ エー／エス |
抗体療法
|
|
WO2022053653A1
(en)
|
2020-09-10 |
2022-03-17 |
Genmab A/S |
Bispecific antibodies against cd3 and cd20 for treating chronic lymphocytic leukemia
|
|
CA3192251A1
(en)
|
2020-09-10 |
2022-03-17 |
Genmab A/S |
Bispecific antibody against cd3 and cd20 in combination therapy for treating diffuse large b-cell lymphoma
|
|
TW202227495A
(zh)
|
2020-09-11 |
2022-07-16 |
美商健生生物科技公司 |
用於調節β鏈介導之免疫的方法及組成物
|
|
MX2023003328A
(es)
|
2020-09-24 |
2023-03-27 |
Hoffmann La Roche |
Lineas de celulas de mamifero con desactivacion genica.
|
|
WO2022069724A1
(en)
|
2020-10-02 |
2022-04-07 |
Genmab A/S |
Antibodies capable of binding to ror2 and bispecific antibodies binding to ror2 and cd3
|
|
TW202231292A
(zh)
|
2020-10-13 |
2022-08-16 |
美商健生生物科技公司 |
用於調節分化簇ｉｖ及／或ｖｉｉｉ的經生物工程改造之ｔ細胞介導之免疫力、材料、及其他方法
|
|
US20220135684A1
(en)
|
2020-10-14 |
2022-05-05 |
Xencor, Inc. |
Bispecific antibodies that bind pd-l1 and cd28
|
|
IL302277A
(en)
|
2020-10-22 |
2023-06-01 |
Janssen Biotech Inc |
Proteins comprising delta-like ligand 3 (dll3) antigen binding domains and their uses
|
|
JP2023548109A
(ja)
|
2020-10-28 |
2023-11-15 |
ヤンセン バイオテツク，インコーポレーテツド |
デルタガンマ鎖媒介性免疫を調節するための組成物及び方法
|
|
AU2021374592A1
(en)
|
2020-11-04 |
2023-06-01 |
Genentech, Inc. |
Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies
|
|
US20220144956A1
(en)
|
2020-11-06 |
2022-05-12 |
Xencor, Inc. |
HETERODIMERIC ANTIBODIES THAT BIND TGFbetaRII
|
|
US20250215081A1
(en)
|
2020-11-06 |
2025-07-03 |
Novartis Ag |
Anti-cd19 agent and b cell targeting agent combination therapy for treating b cell malignancies
|
|
JP2023548529A
(ja)
|
2020-11-06 |
2023-11-17 |
ノバルティス アーゲー |
Ｃｄ１９結合分子及びその使用
|
|
CN117120477A
(zh)
|
2020-11-10 |
2023-11-24 |
上海齐鲁制药研究中心有限公司 |
针对密蛋白18a2和cd3的双特异性抗体及其应用
|
|
JP2023552220A
(ja)
*
|
2020-12-03 |
2023-12-14 |
ザイムワークス ビーシー インコーポレイテッド |
ヘテロ二量体ＩｇＡ Ｆｃ構築物及びその使用の方法
|
|
IL303295A
(en)
|
2020-12-07 |
2023-07-01 |
UCB Biopharma SRL |
Multi-specific antibodies and antibody combinations
|
|
MX2023006649A
(es)
|
2020-12-07 |
2023-06-21 |
UCB Biopharma SRL |
Anticuerpos contra interleucina-22.
|
|
KR20230118612A
(ko)
*
|
2020-12-10 |
2023-08-11 |
인벤라 인코포레이티드 |
헤테로다이머화를 위한 직교 돌연변이
|
|
AU2021402065A1
(en)
|
2020-12-17 |
2023-06-29 |
Boehringer Ingelheim International Gmbh |
Bifunctional anti-pd1/il-7 molecules
|
|
CA3204702A1
(en)
|
2020-12-17 |
2022-06-23 |
F. Hoffmann-La Roche Ag |
Anti-hla-g antibodies and use thereof
|
|
CN116601175A
(zh)
|
2020-12-18 |
2023-08-15 |
豪夫迈·罗氏有限公司 |
用于靶向疗法的前体蛋白和试剂盒
|
|
JP2024501662A
(ja)
|
2020-12-22 |
2024-01-15 |
エフ． ホフマン－ラ ロシュ アーゲー |
Ｘｂｐ１を標的とするオリゴヌクレオチド
|
|
WO2022140701A1
(en)
|
2020-12-24 |
2022-06-30 |
Xencor, Inc. |
Icos targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and icos antigen binding domains
|
|
TWI825544B
(zh)
*
|
2020-12-31 |
2023-12-11 |
大陸商信達生物製藥（蘇州）有限公司 |
含異二聚體抗體Ｆｃ的蛋白以及其製備方法
|
|
AU2022205313A1
(en)
|
2021-01-06 |
2023-07-20 |
Tonix Pharma Limited |
Methods of inducing immune tolerance with modified anti-cd154 antibodies
|
|
AU2022206061A1
(en)
|
2021-01-06 |
2023-07-06 |
F. Hoffmann-La Roche Ag |
Combination therapy employing a pd1-lag3 bispecific antibody and a cd20 t cell bispecific antibody
|
|
WO2022148853A1
(en)
|
2021-01-11 |
2022-07-14 |
F. Hoffmann-La Roche Ag |
Immunoconjugates
|
|
CA3210246A1
(en)
|
2021-01-28 |
2022-08-04 |
Janssen Biotech, Inc. |
Psma binding proteins and uses thereof
|
|
EP4294528A2
(en)
|
2021-02-16 |
2023-12-27 |
JANSSEN Pharmaceutica NV |
Trispecific antibody targeting bcma, gprc5d, and cd3
|
|
AU2022224508A1
(en)
|
2021-02-16 |
2023-10-05 |
Janssen Biotech, Inc. |
Materials and methods for enhanced linker targeting
|
|
JP2024512240A
(ja)
|
2021-02-18 |
2024-03-19 |
エフ． ホフマン－ラ ロシュ アーゲー |
複雑な多段階の抗体相互作用を解明するための方法
|
|
AU2022233518A1
(en)
|
2021-03-09 |
2023-10-26 |
Janssen Biotech, Inc. |
Treatment of cancers lacking egfr-activating mutations
|
|
EP4305067A1
(en)
|
2021-03-09 |
2024-01-17 |
Xencor, Inc. |
Heterodimeric antibodies that bind cd3 and cldn6
|
|
JP2024509274A
(ja)
|
2021-03-10 |
2024-02-29 |
ゼンコア インコーポレイテッド |
Ｃｄ３及びｇｐｃ３に結合するヘテロ二量体抗体
|
|
CN116964085A
(zh)
|
2021-03-12 |
2023-10-27 |
根马布股份公司 |
非激活抗体变体
|
|
MX2023011266A
(es)
|
2021-03-24 |
2023-12-07 |
Janssen Biotech Inc |
Proteínas que comprenden dominios de unión al antígeno de cd3 y usos de estas.
|
|
US12180278B2
(en)
|
2021-03-24 |
2024-12-31 |
Janssen Biotech, Inc. |
Antibody targeting CD22 and CD79B
|
|
BR112023019484A2
(pt)
|
2021-03-24 |
2023-12-05 |
Janssen Biotech Inc |
Anticorpo triespecífico que tem como alvo cd79b, cd20 e cd3
|
|
EP4317175A1
(en)
|
2021-03-31 |
2024-02-07 |
Jiangsu Hengrui Pharmaceuticals Co., Ltd. |
Truncated taci polypeptide and fusion protein and use thereof
|
|
WO2022216993A2
(en)
|
2021-04-08 |
2022-10-13 |
Marengo Therapeutics, Inc. |
Multifuntional molecules binding to tcr and uses thereof
|
|
MX2023011964A
(es)
|
2021-04-09 |
2024-01-08 |
Ose Immunotherapeutics |
Nuevo andamio para moléculas bifuncionales con propiedades mejoradas.
|
|
EP4320156A1
(en)
|
2021-04-09 |
2024-02-14 |
Ose Immunotherapeutics |
Scaffold for bifunctioanl molecules comprising pd-1 or cd28 and sirp binding domains
|
|
EP4329800A1
(en)
|
2021-04-30 |
2024-03-06 |
F. Hoffmann-La Roche AG |
Dosing for treatment with anti-cd20/anti-cd3 bispecific antibody
|
|
EP4330282A1
(en)
|
2021-04-30 |
2024-03-06 |
F. Hoffmann-La Roche AG |
Dosing for combination treatment with anti-cd20/anti-cd3 bispecific antibody and anti-cd79b antibody drug conjugate
|
|
KR20240004694A
(ko)
|
2021-05-03 |
2024-01-11 |
유씨비 바이오파마 에스알엘 |
항체
|
|
JP2024519212A
(ja)
|
2021-05-07 |
2024-05-09 |
ジェンマブ エー／エス |
Ｂ７ｈ４およびｃｄ３に結合する二重特異性抗体を含む薬学的組成物
|
|
US20240239898A1
(en)
*
|
2021-05-10 |
2024-07-18 |
Medimmune, Llc |
Modified fcrn binding fragments with improved half-life
|
|
US20240254245A1
(en)
|
2021-05-12 |
2024-08-01 |
Jiangsu Hengrui Pharmaceuticals Co., Ltd. |
Antigen binding molecule specifically binding to rankl and ngf, and medical use thereof
|
|
IL308417A
(en)
|
2021-05-14 |
2024-01-01 |
Genentech Inc |
Methods for the treatment of CD20-positive proliferative disorder with musuntozumab and folatuzumab and dotin
|
|
US20240392020A1
(en)
|
2021-05-14 |
2024-11-28 |
Jiangsu Hengrui Pharmaceuticals Co., Ltd. |
Antigen-binding molecule
|
|
TW202309094A
(zh)
|
2021-05-18 |
2023-03-01 |
美商健生生物科技公司 |
用於識別癌症患者以進行組合治療之方法
|
|
KR20240035444A
(ko)
|
2021-06-11 |
2024-03-15 |
세이지 테라퓨틱스, 인크. |
알츠하이머병 치료를 위한 신경활성 스테로이드
|
|
WO2022266219A1
(en)
|
2021-06-15 |
2022-12-22 |
Xencor, Inc. |
Heterodimeric antibodies that bind claudin18.2 and cd3
|
|
WO2022266221A1
(en)
|
2021-06-16 |
2022-12-22 |
Alector Llc |
Monovalent anti-mertk antibodies and methods of use thereof
|
|
JP2024527262A
(ja)
|
2021-06-16 |
2024-07-24 |
アレクトル エルエルシー |
二重特異性抗ＭｅｒＴＫ及び抗ＰＤＬ１抗体ならびにその使用方法
|
|
AU2022295067A1
(en)
|
2021-06-18 |
2023-12-21 |
F. Hoffmann-La Roche Ag |
Bispecific anti-ccl2 antibodies
|
|
CA3223375A1
(en)
|
2021-06-21 |
2022-12-29 |
Ugur Sahin |
Combination dosage regime of cd137 and pd-l1 binding agents
|
|
JP7477127B2
(ja)
|
2021-06-25 |
2024-05-01 |
中外製薬株式会社 |
抗ｃｔｌａ－４抗体の使用
|
|
AU2022299846B2
(en)
|
2021-06-25 |
2024-08-15 |
Chugai Seiyaku Kabushiki Kaisha |
Anti–ctla-4 antibody
|
|
TW202309078A
(zh)
|
2021-07-02 |
2023-03-01 |
美商建南德克公司 |
治療癌症之方法及組成物
|
|
US20230042465A1
(en)
|
2021-07-09 |
2023-02-09 |
Janssen Biotech, Inc. |
Manufacturing Methods for Producing Anti-TNF Antibody Compositions
|
|
WO2023281466A1
(en)
|
2021-07-09 |
2023-01-12 |
Janssen Biotech, Inc. |
Manufacturing methods for producing anti-il12/il23 antibody compositions
|
|
US20230040065A1
(en)
|
2021-07-09 |
2023-02-09 |
Janssen Biotech, Inc. |
Manufacturing Methods for Producing Anti-TNF Antibody Compositions
|
|
KR20240032959A
(ko)
|
2021-07-14 |
2024-03-12 |
지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 |
Hgfr 및 egfr에 특이적으로 결합하는 항원-결합 분자, 및 이의 약학적 용도
|
|
EP4373859A1
(en)
|
2021-07-22 |
2024-05-29 |
F. Hoffmann-La Roche AG |
Heterodimeric fc domain antibodies
|
|
US20250101103A1
(en)
|
2021-07-27 |
2025-03-27 |
Morphosys Ag |
Combinations of antigen binding molecules
|
|
WO2023010021A1
(en)
|
2021-07-27 |
2023-02-02 |
Xencor, Inc. |
Il-18-fc fusion proteins
|
|
CA3224180A1
(en)
|
2021-07-28 |
2023-02-02 |
F. Hoffmann-La Roche Ag |
Methods and compositions for treating cancer
|
|
GB202111905D0
(en)
|
2021-08-19 |
2021-10-06 |
UCB Biopharma SRL |
Antibodies
|
|
WO2023028612A2
(en)
|
2021-08-27 |
2023-03-02 |
Board Of Regents, The University Of Texas System |
Anti-tslpr (crlf2) antibodies
|
|
AU2022338208A1
(en)
|
2021-09-06 |
2024-03-21 |
Genmab A/S |
Antibodies capable of binding to cd27, variants thereof and uses thereof
|
|
CA3229822A1
(en)
|
2021-09-13 |
2023-03-16 |
Patrick John DOONAN |
Cd33 x v?2 multispecific antibodies for the treatment of cancer
|
|
WO2023043127A1
(ko)
*
|
2021-09-17 |
2023-03-23 |
고려대학교 산학협력단 |
Fc 감마 수용체와의 결합력이 증대된 fc 변이체
|
|
KR20240067092A
(ko)
|
2021-09-23 |
2024-05-16 |
지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 |
항-klb 항체 및 용도
|
|
EP4405392A1
(en)
|
2021-09-24 |
2024-07-31 |
Janssen Biotech, Inc. |
Proteins comprising cd20 binding domains, and uses thereof
|
|
JP2024534620A
(ja)
|
2021-09-27 |
2024-09-20 |
ゼンコア インコーポレイテッド |
Ｂ細胞成熟抗原（ｂｃｍａ）結合ドメイン組成物
|
|
JPWO2023053282A1
(hu)
|
2021-09-29 |
2023-04-06 |
|
|
|
TW202323304A
(zh)
|
2021-09-30 |
2023-06-16 |
大陸商江蘇恆瑞醫藥股份有限公司 |
抗ｉｌ２３抗體融合蛋白及用途
|
|
JP7503215B2
(ja)
|
2021-10-08 |
2024-06-19 |
ジェンマブ エー／エス |
Ｃｄ３０及びｃｄ３に結合する抗体
|
|
AR127269A1
(es)
|
2021-10-08 |
2024-01-03 |
Chugai Pharmaceutical Co Ltd |
Formulación de anticuerpo anti-hla-dq2.5
|
|
CA3234731A1
(en)
|
2021-10-14 |
2023-04-20 |
F. Hoffmann-La Roche Ag |
New interleukin-7 immunoconjugates
|
|
CN118139648A
(zh)
|
2021-10-14 |
2024-06-04 |
豪夫迈·罗氏有限公司 |
用于治疗癌症的替代的PD1-IL7v免疫缀合物
|
|
JP2024539139A
(ja)
|
2021-10-20 |
2024-10-28 |
シンセカイン インコーポレイテッド |
ヘテロ二量体ｆｃサイトカインおよびその使用
|
|
AU2022377084A1
(en)
|
2021-11-01 |
2024-06-20 |
Janssen Biotech, Inc. |
Compositions and methods for the modulation of beta chain-mediated immunity
|
|
MX2024005392A
(es)
|
2021-11-03 |
2024-08-06 |
Janssen Biotech Inc |
Métodos para tratar cánceres y potenciar la eficacia de anticuerpos biespecíficos para bcmaxcd3.
|
|
WO2023086772A1
(en)
|
2021-11-12 |
2023-05-19 |
Xencor, Inc. |
Bispecific antibodies that bind to b7h3 and nkg2d
|
|
EP4436669A1
(en)
|
2021-11-22 |
2024-10-02 |
Janssen Biotech, Inc. |
Compositions comprising enhanced multispecific binding agents for an immune response
|
|
CN118284809A
(zh)
|
2021-11-25 |
2024-07-02 |
豪夫迈·罗氏有限公司 |
少量抗体副产物的定量
|
|
US20230183360A1
(en)
|
2021-12-09 |
2023-06-15 |
Janssen Biotech, Inc. |
Use of Amivantamab to Treat Colorectal Cancer
|
|
AR127887A1
(es)
|
2021-12-10 |
2024-03-06 |
Hoffmann La Roche |
Anticuerpos que se unen a cd3 y plap
|
|
KR20240121820A
(ko)
*
|
2021-12-15 |
2024-08-09 |
메디뮨 리미티드 |
이형이량체 릴랙신 융합체를 이용한 치료
|
|
CN118715024A
(zh)
|
2022-01-24 |
2024-09-27 |
诺夫免疫股份有限公司 |
用于细胞因子信号传导通路的选择性激活的组合物和方法
|
|
EP4477669A1
(en)
|
2022-02-07 |
2024-12-18 |
Jiangsu Hengrui Pharmaceuticals Co., Ltd. |
Antigen-binding molecule specifically binding to psma and cd3, and pharmaceutical use thereof
|
|
TW202342057A
(zh)
|
2022-02-07 |
2023-11-01 |
美商健生生物科技公司 |
用於減少用ｅｇｆｒ／ｍｅｔ雙特異性抗體治療之患者的輸注相關反應之方法
|
|
KR20240145492A
(ko)
|
2022-02-11 |
2024-10-07 |
지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 |
면역접합체 및 이의 용도
|
|
KR20240161977A
(ko)
|
2022-02-23 |
2024-11-13 |
젠코어 인코포레이티드 |
항-CD28 x 항-PSMA 항체
|
|
US20240059786A1
(en)
|
2022-02-24 |
2024-02-22 |
Xencor, Inc. |
Anti-cd28 x anti-trop2 antibodies
|
|
US20230340128A1
(en)
|
2022-02-24 |
2023-10-26 |
Xencor, Inc. |
Anti-cd28 x anti-msln antibodies
|
|
WO2023170474A1
(en)
|
2022-03-07 |
2023-09-14 |
Novimmune Sa |
Cd28 bispecific antibodies for targeted t cell activation
|
|
WO2024026472A2
(en)
|
2022-07-29 |
2024-02-01 |
Alector Llc |
Transferrin receptor antigen-binding domains and uses therefor
|
|
JP2025509702A
(ja)
|
2022-03-14 |
2025-04-11 |
ラムキャップ バイオ ガンマ エージー |
ＧＰＣ３陽性悪性細胞を標的殺傷するための二重特異性ＧＰＣ３ｘＣＤ２８抗体およびＧＰＣ３ｘＣＤ３抗体ならびにそれらの組み合わせ
|
|
KR20240161961A
(ko)
|
2022-03-14 |
2024-11-13 |
지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 |
Gprc5d 및 cd3에 특이적으로 결합하는 항원 결합 분자 및 이의 의약적 용도
|
|
WO2023174521A1
(en)
|
2022-03-15 |
2023-09-21 |
Genmab A/S |
Binding agents binding to epcam and cd137
|
|
JP2025512785A
(ja)
|
2022-03-23 |
2025-04-22 |
エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト |
抗ｃｄ２０／抗ｃｄ３二重特異性抗体及び化学療法の併用処置
|
|
WO2023192850A1
(en)
|
2022-03-29 |
2023-10-05 |
Ngm Biopharmaceuticals, Inc. |
Ilt3 and cd3 binding agents and methods of use thereof
|
|
WO2023196905A1
(en)
|
2022-04-07 |
2023-10-12 |
Xencor, Inc. |
Lag-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and lag-3 antigen binding domains
|
|
WO2023201309A1
(en)
|
2022-04-13 |
2023-10-19 |
Xencor, Inc. |
Antibodies that bind pd-l1, pd-l2 and/or cd28
|
|
AU2023251832A1
(en)
|
2022-04-13 |
2024-10-17 |
F. Hoffmann-La Roche Ag |
Pharmaceutical compositions of anti-cd20/anti-cd3 bispecific antibodies and methods of use
|
|
EP4511388A1
(en)
|
2022-04-19 |
2025-02-26 |
F. Hoffmann-La Roche AG |
Improved production cells
|
|
AU2023269545A1
(en)
|
2022-05-12 |
2024-11-14 |
BioNTech SE |
Binding agents capable of binding to cd27 in combination therapy
|
|
JP2025516633A
(ja)
|
2022-05-12 |
2025-05-30 |
ジェンマブ エー／エス |
併用療法においてｃｄ２７に結合する能力を有する結合剤
|
|
AR129445A1
(es)
|
2022-05-27 |
2024-08-28 |
Glaxosmithkline Ip Dev Ltd |
USO DE PROTEÍNAS DE UNIÓN A TNF-a Y PROTEÍNAS DE UNIÓN A IL-7 EN EL TRATAMIENTO MÉDICO
|
|
JP2025517572A
(ja)
|
2022-06-03 |
2025-06-05 |
エフ． ホフマン－ラ ロシュ アーゲー |
改良された産生細胞
|
|
EP4545564A1
(en)
|
2022-06-23 |
2025-04-30 |
Jiangsu Hengrui Pharmaceuticals Co., Ltd. |
Antigen-binding molecule specifically binding to dll3 and cd3, and pharmaceutical use thereof
|
|
US20240317866A1
(en)
|
2022-06-30 |
2024-09-26 |
Janssen Biotech, Inc. |
Use of Anti-EGFR/Anti-Met Antibody to Treat Gastric or Esophageal Cancer
|
|
IL318098A
(en)
|
2022-07-01 |
2025-02-01 |
Alk Abell? As |
IGE-FCER pushers
|
|
CN119584983A
(zh)
|
2022-07-29 |
2025-03-07 |
艾莱克特有限责任公司 |
Cd98hc抗原结合结构域及其用途
|
|
CN119907811A
(zh)
|
2022-08-02 |
2025-04-29 |
Ose免疫疗法公司 |
针对cd28的多功能分子
|
|
WO2024027815A1
(zh)
|
2022-08-05 |
2024-02-08 |
江苏恒瑞医药股份有限公司 |
特异性结合gucy2c和cd3的抗原结合分子及其医药用途
|
|
CN115353552B
(zh)
*
|
2022-08-19 |
2023-07-18 |
山东大学 |
一种降低蛋白质变性温度的方法及其突变体与应用
|
|
TW202423970A
(zh)
|
2022-10-10 |
2024-06-16 |
瑞士商赫孚孟拉羅股份公司 |
Ｇｐｒｃ５ｄ ｔｃｂ及ｃｄ３８抗體之組合療法
|
|
TW202430211A
(zh)
|
2022-10-10 |
2024-08-01 |
瑞士商赫孚孟拉羅股份公司 |
Ｇｐｒｃ５ｄ ｔｃｂ及ｉｍｉｄ之組合療法
|
|
TW202423969A
(zh)
|
2022-10-10 |
2024-06-16 |
瑞士商赫孚孟拉羅股份公司 |
Ｇｐｒｃ５ｄ ｔｃｂ及蛋白酶體抑制劑之組合療法
|
|
WO2024079069A1
(en)
|
2022-10-12 |
2024-04-18 |
F. Hoffmann-La Roche Ag |
Method for classifying cells
|
|
AU2023362569A1
(en)
|
2022-10-21 |
2025-04-24 |
Novimmune Sa |
Pd-l1xcd28 bispecific antibodies for immune checkpoint-dependent t cell activation
|
|
WO2024089551A1
(en)
|
2022-10-25 |
2024-05-02 |
Janssen Biotech, Inc. |
Msln and cd3 binding agents and methods of use thereof
|
|
WO2024092038A2
(en)
|
2022-10-25 |
2024-05-02 |
Ablexis, Llc |
Anti-cd3 antibodies
|
|
WO2024094660A1
(en)
|
2022-10-31 |
2024-05-10 |
Genmab A/S |
Cd38 antibodies and uses thereof
|
|
KR20250096769A
(ko)
|
2022-11-01 |
2025-06-27 |
상하이 치루 파마슈티컬 리서치 앤 디벨롭먼트 센터 리미티드 |
글리피칸-3에 대한 이중특이성 항체 및 이의 용도
|
|
AU2023375177A1
(en)
|
2022-11-02 |
2025-06-19 |
Janssen Biotech, Inc. |
Methods of treating cancers
|
|
WO2024102636A1
(en)
|
2022-11-07 |
2024-05-16 |
Xencor, Inc. |
Bispecific antibodies that bind to b7h3 and mica/b
|
|
WO2024102693A2
(en)
|
2022-11-07 |
2024-05-16 |
Xencor, Inc. |
Il-18-fc fusion proteins
|
|
WO2024100170A1
(en)
|
2022-11-11 |
2024-05-16 |
F. Hoffmann-La Roche Ag |
Antibodies binding to hla-a*02/foxp3
|
|
WO2024102948A1
(en)
|
2022-11-11 |
2024-05-16 |
Celgene Corporation |
Fc receptor-homolog 5 (fcrh5) specific binding molecules and bispecific t-cell engaging antibodies including same and related methods
|
|
WO2024107731A2
(en)
|
2022-11-14 |
2024-05-23 |
Ablexis, Llc |
Anti-pd-l1 antibodies
|
|
WO2024104988A1
(en)
|
2022-11-15 |
2024-05-23 |
F. Hoffmann-La Roche Ag |
Recombinant binding proteins with activatable effector domain
|
|
CN120187748A
(zh)
|
2022-11-15 |
2025-06-20 |
豪夫迈·罗氏有限公司 |
抗原结合分子
|
|
CN120265651A
(zh)
|
2022-11-25 |
2025-07-04 |
中外制药株式会社 |
用于生产蛋白质的方法
|
|
WO2024143442A1
(ja)
*
|
2022-12-27 |
2024-07-04 |
中外製薬株式会社 |
会合が制御されたポリペプチド
|
|
WO2024153722A1
(en)
|
2023-01-20 |
2024-07-25 |
F. Hoffmann-La Roche Ag |
Immunoconjugates
|
|
WO2024156672A1
(en)
|
2023-01-25 |
2024-08-02 |
F. Hoffmann-La Roche Ag |
Antibodies binding to csf1r and cd3
|
|
WO2024163494A1
(en)
|
2023-01-31 |
2024-08-08 |
F. Hoffmann-La Roche Ag |
Methods and compositions for treating non-small cell lung cancer and triple-negative breast cancer
|
|
WO2024163009A1
(en)
|
2023-01-31 |
2024-08-08 |
Genentech, Inc. |
Methods and compositions for treating urothelial bladder cancer
|
|
WO2024166047A1
(en)
|
2023-02-09 |
2024-08-15 |
Janssen Biotech, Inc. |
Anti-v beta 17/anti-cd123 bispecific antibodies
|
|
AR132033A1
(es)
*
|
2023-03-03 |
2025-05-21 |
Astrazeneca Ab |
Formulación farmacéutica
|
|
WO2024184287A1
(en)
|
2023-03-06 |
2024-09-12 |
F. Hoffmann-La Roche Ag |
Combination therapy of an anti-egfrviii/anti-cd3 antibody and an tumor-targeted 4-1bb agonist
|
|
WO2024188965A1
(en)
|
2023-03-13 |
2024-09-19 |
F. Hoffmann-La Roche Ag |
Combination therapy employing a pd1-lag3 bispecific antibody and an hla-g t cell bispecific antibody
|
|
WO2024189544A1
(en)
|
2023-03-13 |
2024-09-19 |
Janssen Biotech, Inc. |
Combination therapies with bi-specific anti-egfr/c-met antibodies and anti-pd-1 antibodies
|
|
US20250043001A1
(en)
|
2023-03-14 |
2025-02-06 |
Xencor, Inc. |
Anti-cd28 compositions
|
|
WO2024208776A1
(en)
|
2023-04-03 |
2024-10-10 |
F. Hoffmann-La Roche Ag |
Agonistic split antibodies
|
|
WO2024208777A1
(en)
|
2023-04-03 |
2024-10-10 |
F. Hoffmann-La Roche Ag |
All-in-one agonistic antibodies
|
|
WO2024208898A1
(en)
|
2023-04-05 |
2024-10-10 |
Genmab A/S |
Pharmaceutical compositions comprising antibodies binding to cd30 and cd3
|
|
US20250084179A1
(en)
|
2023-04-14 |
2025-03-13 |
Xencor, Inc. |
Anti-cd28 x anti-trop2 antibodies
|
|
WO2024220805A1
(en)
*
|
2023-04-21 |
2024-10-24 |
Emory University |
Heterodimeric antibodies, uses in therapeutic applications, and compositions related thereto
|
|
WO2024221187A1
(en)
*
|
2023-04-24 |
2024-10-31 |
Biomap Intelligence Technology Sg Pte.Ltd. |
Heteromultimer polypeptides
|
|
US20240360220A1
(en)
|
2023-04-28 |
2024-10-31 |
Xencor, Inc. |
Orthogonal multimeric proteins
|
|
WO2024231320A1
(en)
|
2023-05-08 |
2024-11-14 |
F. Hoffmann-La Roche Ag |
Targeted interferon alpha fusion proteins and methods of use
|
|
TW202509071A
(zh)
|
2023-05-12 |
2025-03-01 |
丹麥商珍美寶股份有限公司 |
能夠與ｏｘ４０結合之抗體、其變異體及其用途
|
|
TW202509065A
(zh)
|
2023-05-16 |
2025-03-01 |
瑞士商赫孚孟拉羅股份公司 |
經ｐｄ－１調節之ｉｌ－２免疫結合物及其用途
|
|
WO2024241273A1
(en)
|
2023-05-23 |
2024-11-28 |
Janssen Biotech, Inc. |
Methods for treatment of non-small cell lung cancer (nsclc)
|
|
WO2024242490A1
(ko)
*
|
2023-05-24 |
2024-11-28 |
삼성바이오로직스 주식회사 |
Ch3 도메인 변이체 또는 이를 포함하는 이중 특이적 항체
|
|
WO2024263904A1
(en)
|
2023-06-23 |
2024-12-26 |
Genentech, Inc. |
Methods for treatment of liver cancer
|
|
WO2024263195A1
(en)
|
2023-06-23 |
2024-12-26 |
Genentech, Inc. |
Methods for treatment of liver cancer
|
|
WO2025007037A1
(en)
|
2023-06-28 |
2025-01-02 |
Dragonfly Therapeutics, Inc. |
Variant il-2 proteins
|
|
US12351650B2
(en)
|
2023-06-30 |
2025-07-08 |
Genmab A/S |
Antibodies binding to fibroblast activation protein alpha and death receptor 4
|
|
WO2025021838A1
(en)
|
2023-07-26 |
2025-01-30 |
F. Hoffmann-La Roche Ag |
Antibodies binding to cd3
|
|
WO2025027511A1
(en)
|
2023-07-30 |
2025-02-06 |
Janssen Biotech, Inc. |
Molecules that bind to mutant calreticulin and uses thereof
|
|
US20250136688A1
(en)
|
2023-08-07 |
2025-05-01 |
Janssen Biotech, Inc. |
Stabilized cd3 antigen binding agents and methods of use thereof
|
|
WO2025034715A1
(en)
|
2023-08-07 |
2025-02-13 |
Janssen Biotech, Inc. |
Gucy2c antibodies and uses thereof
|
|
WO2025032508A1
(en)
|
2023-08-07 |
2025-02-13 |
Janssen Biotech, Inc. |
Enpp3 and cd3 binding agents and methods of use thereof
|
|
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(en)
|
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|
|
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|
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|
|
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|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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First line treatment in egfr exon 20 insertion-mutated advanced non-small cell lung cancer
|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|