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EA200600732A1 - Макроциклические карбоновые кислоты и ацилсульфонамиды в качестве ингибиторов репликации вируса гепатита с - Google Patents

Макроциклические карбоновые кислоты и ацилсульфонамиды в качестве ингибиторов репликации вируса гепатита с

Info

Publication number
EA200600732A1
EA200600732A1 EA200600732A EA200600732A EA200600732A1 EA 200600732 A1 EA200600732 A1 EA 200600732A1 EA 200600732 A EA200600732 A EA 200600732A EA 200600732 A EA200600732 A EA 200600732A EA 200600732 A1 EA200600732 A1 EA 200600732A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hepatit
carbic
macrocyclic
acids
virus inhibitors
Prior art date
Application number
EA200600732A
Other languages
English (en)
Other versions
EA011857B8 (ru
EA011857B1 (ru
Inventor
Лоренс М. Блэтт
Стивен Марк Венгловски
Стивен Вейд Эндрьюс
Ютонг Джианг
Эйприл Лайн Кеннеди
Кевин Рональд Кондроски
Джон Энтони Джоси
Питер Джон Стенджел
Мачендер Р. Маддуру
Джордж Эндрю Догерти
Бенджамин Т. Вуддард
Original Assignee
Интермьюн, Инк.
Эррей Биофарма Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Интермьюн, Инк., Эррей Биофарма Инк. filed Critical Интермьюн, Инк.
Publication of EA200600732A1 publication Critical patent/EA200600732A1/ru
Publication of EA011857B1 publication Critical patent/EA011857B1/ru
Publication of EA011857B8 publication Critical patent/EA011857B8/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Настоящее изобретение раскрывает соединения общих формул I-IX, а также композиции, включая фармацевтические композиции, содержащие соединение согласно изобретению. Согласно изобретению также предложены способы лечения, включая способы лечения вирусной инфекции гепатита С и способы лечения фиброза печени, которые включают, по существу, введение пациенту, который нуждается в лечении, эффективного количества соединения или композиции согласно изобретению.
EA200600732A 2003-10-14 2004-10-13 Макроциклические карбоновые кислоты и ацилсульфонамиды в качестве ингибиторов репликации вируса гепатита с EA011857B8 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US51154103P 2003-10-14 2003-10-14
US61246004P 2004-09-22 2004-09-22
PCT/US2004/033970 WO2005037214A2 (en) 2003-10-14 2004-10-13 Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of hcv replication

Publications (3)

Publication Number Publication Date
EA200600732A1 true EA200600732A1 (ru) 2006-08-25
EA011857B1 EA011857B1 (ru) 2009-06-30
EA011857B8 EA011857B8 (ru) 2012-08-30

Family

ID=34467992

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200600732A EA011857B8 (ru) 2003-10-14 2004-10-13 Макроциклические карбоновые кислоты и ацилсульфонамиды в качестве ингибиторов репликации вируса гепатита с

Country Status (29)

Country Link
EP (2) EP1680137B1 (ru)
JP (3) JP4584260B2 (ru)
KR (1) KR100853579B1 (ru)
CN (2) CN103145715B (ru)
AP (2) AP2287A (ru)
AR (2) AR046422A1 (ru)
AU (1) AU2004281780B2 (ru)
BR (1) BRPI0415373A (ru)
CA (1) CA2540858C (ru)
CY (1) CY1113809T1 (ru)
DK (1) DK1680137T3 (ru)
EA (1) EA011857B8 (ru)
EC (2) ECSP066570A (ru)
ES (1) ES2398912T3 (ru)
GE (1) GEP20084560B (ru)
HR (1) HRP20130098T1 (ru)
IL (3) IL174704A (ru)
IS (1) IS2876B (ru)
MA (1) MA28152A1 (ru)
MX (1) MXPA06003963A (ru)
MY (1) MY144593A (ru)
NO (1) NO343231B1 (ru)
NZ (1) NZ546347A (ru)
OA (1) OA13315A (ru)
PL (1) PL1680137T3 (ru)
PT (1) PT1680137E (ru)
RS (3) RS20110578A3 (ru)
TW (2) TWI375679B (ru)
WO (1) WO2005037214A2 (ru)

Cited By (1)

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