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RU2384580C2 - Ингибиторы фосфатидилинозитол-3-киназы - Google Patents

Ингибиторы фосфатидилинозитол-3-киназы Download PDF

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RU2384580C2
RU2384580C2 RU2005137358/04A RU2005137358A RU2384580C2 RU 2384580 C2 RU2384580 C2 RU 2384580C2 RU 2005137358/04 A RU2005137358/04 A RU 2005137358/04A RU 2005137358 A RU2005137358 A RU 2005137358A RU 2384580 C2 RU2384580 C2 RU 2384580C2
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phosphatidylinositol
kinase inhibitors
kinase
compounds
formula
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Айан БРЮС (GB)
Айан Брюс
Бернар КЮНУ (CH)
Бернар КЮНУ
Томас Хьюго КЕЛЛЕР (SG)
Томас Хьюго КЕЛЛЕР
Гейнор Элизабет ПИЛГРИМ (GB)
Гейнор Элизабет ПИЛГРИМ
Никола ПРЕСС (GB)
Никола ПРЕСС
Даррен Марк ЛЕ-ГРАН (GB)
Даррен Марк ЛЕ-ГРАН
Кэти РИТЧИ (GB)
Кэти Ритчи
Барбара ВАЛАДЕ (GB)
Барбара ВАЛАДЕ
Джуди ХЕЙЛЕР (GB)
Джуди ХЕЙЛЕР
Эмма БАДД (GB)
Эмма Бадд
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Новартис Аг
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Abstract

Изобретение относится к соединениям общей формулы (XXI) ! ! где значения R1, Y, Ra и Rb указаны в п.п.1 и 2 формулы изобретения, в качестве ингибитора фосфатидилинозитол-3-киназы, фармацевтической композиции на их основе и их применению. Соединения могут найти применение для лечения и профилактики заболеваний, опосредованных фосфатидилинозитол-3-киназой, например, респираторных заболеваний, аллергий, ревматоидного артрита, остеоартрита. 4 н. и 1 з.п. ф-лы, 5 табл.

Description

Текст описания приведен в факсимильном виде.

Claims (5)

1. Соединение формулы XXI
Figure 00000001

где R1, Y, Ra и Rb такие, как показано в следующей таблице:
Figure 00000002

Figure 00000003

Figure 00000004
2. Соединение формулы XXI
Figure 00000001

где R1, Y, Ra и Rb такие, как показано в следующей таблице:
Figure 00000005

Figure 00000006

Figure 00000007
Figure 00000008

Figure 00000009
Figure 00000010
Figure 00000011
Figure 00000012
Figure 00000013
3. Соединение по п.1 или 2, обладающее свойством ингибитора фосфатидилинозитол-3-киназы.
4. Фармацевтическая композиция, обладающая свойством ингибитора фосфатидилинозитол-3-киназы, включающая в качестве активного ингредиента соединение по любому из пп.1-3.
5. Применение соединения по любому из пп.1-3 для получения лекарственного средства для лечения заболевания, опосредованного фосфатидилинозитол-3-киназой.
RU2005137358/04A 2003-05-02 2004-04-30 Ингибиторы фосфатидилинозитол-3-киназы RU2384580C2 (ru)

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