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SG11201508223YA - Treatment of cancer with dihydropyrazino-pyrazines - Google Patents

Treatment of cancer with dihydropyrazino-pyrazines

Info

Publication number
SG11201508223YA
SG11201508223YA SG11201508223YA SG11201508223YA SG11201508223YA SG 11201508223Y A SG11201508223Y A SG 11201508223YA SG 11201508223Y A SG11201508223Y A SG 11201508223YA SG 11201508223Y A SG11201508223Y A SG 11201508223YA SG 11201508223Y A SG11201508223Y A SG 11201508223YA
Authority
SG
Singapore
Prior art keywords
dihydropyrazino
pyrazines
cancer
treatment
Prior art date
Application number
SG11201508223YA
Inventor
Heather Raymon
Kristen Mae Hege
Original Assignee
Signal Pharm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Signal Pharm Llc filed Critical Signal Pharm Llc
Publication of SG11201508223YA publication Critical patent/SG11201508223YA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurology (AREA)
SG11201508223YA 2013-04-17 2014-04-16 Treatment of cancer with dihydropyrazino-pyrazines SG11201508223YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361813071P 2013-04-17 2013-04-17
PCT/US2014/034304 WO2014172425A1 (en) 2013-04-17 2014-04-16 Treatment of cancer with dihydropyrazino-pyrazines

Publications (1)

Publication Number Publication Date
SG11201508223YA true SG11201508223YA (en) 2015-11-27

Family

ID=50736197

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201508223YA SG11201508223YA (en) 2013-04-17 2014-04-16 Treatment of cancer with dihydropyrazino-pyrazines
SG10201801965RA SG10201801965RA (en) 2013-04-17 2014-04-16 Treatment of cancer with dihydropyrazino-pyrazines

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201801965RA SG10201801965RA (en) 2013-04-17 2014-04-16 Treatment of cancer with dihydropyrazino-pyrazines

Country Status (20)

Country Link
US (2) US9630966B2 (en)
EP (2) EP4218763A1 (en)
JP (1) JP6382945B2 (en)
KR (1) KR102271344B1 (en)
CN (2) CN105473142A (en)
AU (1) AU2014254052B2 (en)
BR (1) BR112015026238A8 (en)
CA (1) CA2908353C (en)
EA (1) EA030808B1 (en)
ES (1) ES2944478T3 (en)
IL (1) IL241950B (en)
MX (2) MX377267B (en)
NI (1) NI201500150A (en)
NZ (1) NZ629332A (en)
PH (3) PH12021552945B1 (en)
SA (1) SA515370012B1 (en)
SG (2) SG11201508223YA (en)
TW (2) TWI604843B (en)
UA (1) UA119538C2 (en)
WO (1) WO2014172425A1 (en)

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* Cited by examiner, † Cited by third party
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HK1221150A1 (en) 2013-04-17 2017-05-26 西格诺药品有限公司 Treatment of cancer with dihydropyrazino-pyrazines
WO2014172431A1 (en) 2013-04-17 2014-10-23 Signal Pharmaceuticals, Llc Combination therapy comprising a dihydropyrazino-pyrazine compound and an androgen receptor antagonist for treating prostate cancer
JP6382949B2 (en) 2013-04-17 2018-08-29 シグナル ファーマシューティカルズ，エルエルシー Combination therapy comprising a TOR kinase inhibitor and a 5-substituted quinazolinone compound for the treatment of cancer
EP3549940A1 (en) 2013-04-17 2019-10-09 Signal Pharmaceuticals, LLC Pharmaceutical formulations, of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl) pyridin-3-yl) -3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one
US9604939B2 (en) 2013-05-29 2017-03-28 Signal Pharmaceuticals, Llc Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-YL)pyridin-3-YL)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-B]pyrazin-2(1H)-one, a solid form thereof and methods of their use
NZ714742A (en) 2014-04-16 2017-04-28 Signal Pharm Llc Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use
ES2823756T3 (en) 2014-04-16 2021-05-10 Signal Pharm Llc Methods for treating cancer using TOR kinase inhibitor combination therapy
JP2017511367A (en) 2014-04-16 2017-04-20 シグナル ファーマシューティカルズ，エルエルシー 1-ethyl-7- (2-methyl-6- (1H-1,2,4-triazol-3-yl) pyridin-3-yl) -3,4-dihydropyrazino [2,3-b] pyrazine-2 Solid forms comprising (1H) -one and coforms, compositions thereof and methods of use
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WO2022266468A1 (en) * 2021-06-18 2022-12-22 Yale University Anti-cancer compounds and methods of use

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