CN102020697A - 作为hcv复制抑制剂的巨环羧酸和酰基磺酰胺 - Google Patents
作为hcv复制抑制剂的巨环羧酸和酰基磺酰胺 Download PDFInfo
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
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- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Description
5-甲基-1-(2′-吡啶基)-2-(1H)嘧啶, | 6-甲基-1-苯基-3-(1H)吡啶酮, |
6-甲基-1-苯基-2-(1H)吡啶酮, | 5-甲基-1-对甲苯基-3-(1H)吡啶酮, |
5-甲基-3-苯基-1-(2′-噻吩基)-2-(1H)吡啶酮, | 5-甲基-1-(2′-萘基)-3-(1H)吡啶酮, |
5-甲基-1-(2′-萘基)-2-(1H)吡啶酮, | 5-甲基-1-苯基-3-(1H)吡啶酮, |
5-甲基-1-对甲苯基-2-(1H)吡啶酮, | 5-甲基-1-(5′-喹啉基)-3-(1H)吡啶酮, |
5-甲基-1-(1′-萘基)-2-(1H)吡啶酮, | 5-乙基-1-苯基-3-(1H)吡啶酮, |
5-乙基-1-苯基-2-(1H)吡啶酮, | 5-甲基-1-(4′-甲氧基苯基)-3-(1H)吡啶酮, |
5-甲基-1-(5′-喹啉基)-2-(1H)吡啶酮, | 4-甲基-1-苯基-3-(1H)吡啶酮, |
5-甲基-1-(4′-喹啉基)-2-(1H)吡啶酮, | 5-甲基-1-(3′-吡啶基)-3-(1H)吡啶酮, |
5-甲基-1-(4′-吡啶基)-2-(1H)吡啶酮, | 5-甲基-1-(2′-噻吩基)-3-(1H)吡啶酮, |
3-甲基-1-苯基-2-(1H)吡啶酮, | 5-甲基-1-(2′-吡啶基)-3-(1H)吡啶酮, |
5-甲基-1-(4′-甲氧基苯基)-2-(1H)吡啶酮, | 5-甲基-1-(2′-喹啉基)-3-(1H)吡啶酮, |
1-苯基-2-(1H)吡啶酮, | 1-苯基-3-(1H)嘧啶, |
1,3-二苯基-2-(1H)吡啶酮, | 1-(2′-呋喃基)-5-甲基-3-(1H)吡啶酮, |
1,3-二苯基-5-甲基-2-(1H)吡啶酮, | 1-(4′-氯苯基)-5-甲基-3-(1H)吡啶。 |
5-甲基-1-(3′-三氟甲基苯基)-2-(1H)-吡啶酮, | |
3-乙基-1-苯基-2-(1H)吡啶酮, | |
5-甲基-1-(3′-吡啶基)-2-(1H)吡啶酮, | |
5-甲基-1-(3-硝基苯基)-2-(1H)吡啶酮, | |
3-(4′-氯苯基)-5-甲基-1-苯基-2-(1H)吡啶酮, | |
5-甲基-1-(2′-噻吩基)-2-(1H)吡啶酮, | |
5-甲基-1-(2′-噻唑基)-2-(1H)吡啶酮, | |
3,6-二甲基-1-苯基-2-(1H)吡啶酮, | |
1-(4′-氯苯基)-5-甲基-2-(1H)吡啶酮, | |
1-(2′-咪唑基)-5-甲基-2-(1H)吡啶酮, | |
1-(4′-硝基苯基)-2-(1H)吡啶酮, | |
1-(2′-呋喃基)-5-甲基-2-(1H)吡啶酮, | |
1-苯基-3-(4′-氯苯基)-2-(1H)吡啶。 |
Claims (54)
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CN (2) | CN103145715B (zh) |
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BR (1) | BRPI0415373A (zh) |
CA (1) | CA2540858C (zh) |
CY (1) | CY1113809T1 (zh) |
DK (1) | DK1680137T3 (zh) |
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ES (1) | ES2398912T3 (zh) |
GE (1) | GEP20084560B (zh) |
HR (1) | HRP20130098T1 (zh) |
IL (3) | IL174704A (zh) |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105175491A (zh) * | 2015-07-13 | 2015-12-23 | 山东大学 | 一种含有羟脯氨酸骨架的多肽类ns3丝氨酸蛋白酶抑制剂及其制备方法和应用 |
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MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
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HRP20130098T1 (hr) * | 2003-10-14 | 2013-02-28 | F. Hoffmann - La Roche Ag | MAKROCIKLIÄŚKE KARBOKSILNE KISELINE I ACILSULFONAMIDNI SPOJEVI KAO INHIBITORI REPLIKACIJE HCV-a |
US20050182252A1 (en) | 2004-02-13 | 2005-08-18 | Reddy K. R. | Novel 2'-C-methyl nucleoside derivatives |
JP4950026B2 (ja) * | 2004-03-30 | 2012-06-13 | インターミューン・インコーポレーテッド | ウイルス複製阻害剤としての大環状化合物 |
US7323447B2 (en) | 2005-02-08 | 2008-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
RU2456296C2 (ru) * | 2005-03-08 | 2012-07-20 | Берингер Ингельхайм Интернациональ Гмбх | Способ получения макроциклических соединений |
DK2332909T3 (da) * | 2005-04-13 | 2014-11-10 | Astex Therapeutics Ltd | Hydroxybenzamidderivater og deres anvendelse som inhibitorer af hsp90 |
US7592336B2 (en) | 2005-05-10 | 2009-09-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
WO2007002051A1 (en) * | 2005-06-22 | 2007-01-04 | Smithkline Beecham Corporation | Carboline derivatives and their use as inhibitors of flaviviridae infections |
US7601686B2 (en) * | 2005-07-11 | 2009-10-13 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
SG166791A1 (en) | 2005-07-25 | 2010-12-29 | Intermune Inc | Novel macrocyclic inhibitors of hepatitis c virus replication |
DE602006019741D1 (de) * | 2005-07-29 | 2011-03-03 | Medivir Ab | Makrocyclische inhibitoren des hepatitis-c-virus |
JP5426164B2 (ja) | 2005-07-29 | 2014-02-26 | ヤンセン・アールアンドデイ・アイルランド | C型肝炎ウイルスの大環式インヒビター |
ATE496908T1 (de) * | 2005-07-29 | 2011-02-15 | Tibotec Pharm Ltd | Makrocyclische inhibitoren des hepatitis-c-virus |
CA2618682C (en) | 2005-08-12 | 2011-06-21 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
KR20080056295A (ko) * | 2005-10-11 | 2008-06-20 | 인터뮨, 인크. | C형 간염 바이러스 복제를 억제하기 위한 화합물 및 방법 |
US7772183B2 (en) | 2005-10-12 | 2010-08-10 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7741281B2 (en) | 2005-11-03 | 2010-06-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
RU2494095C2 (ru) | 2005-12-23 | 2013-09-27 | Вайет | Модифицированные миметики лизина |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105175491A (zh) * | 2015-07-13 | 2015-12-23 | 山东大学 | 一种含有羟脯氨酸骨架的多肽类ns3丝氨酸蛋白酶抑制剂及其制备方法和应用 |
CN105175491B (zh) * | 2015-07-13 | 2019-01-11 | 山东大学 | 一种含有羟脯氨酸骨架的多肽类ns3丝氨酸蛋白酶抑制剂及其制备方法和应用 |
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