US6767991B1
(en)
|
1997-08-11 |
2004-07-27 |
Boehringer Ingelheim (Canada) Ltd. |
Hepatitis C inhibitor peptides
|
AU757072B2
(en)
*
|
1997-08-11 |
2003-01-30 |
Boehringer Ingelheim (Canada) Ltd. |
Hepatitis C inhibitor peptide analogues
|
US6608027B1
(en)
|
1999-04-06 |
2003-08-19 |
Boehringer Ingelheim (Canada) Ltd |
Macrocyclic peptides active against the hepatitis C virus
|
UA74546C2
(en)
*
|
1999-04-06 |
2006-01-16 |
Boehringer Ingelheim Ca Ltd |
Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition
|
US7122627B2
(en)
|
1999-07-26 |
2006-10-17 |
Bristol-Myers Squibb Company |
Lactam inhibitors of Hepatitis C virus NS3 protease
|
SV2003000617A
(en)
|
2000-08-31 |
2003-01-13 |
Lilly Co Eli |
INHIBITORS OF PROTEASA PEPTIDOMIMETICA REF. X-14912M
|
US6846806B2
(en)
|
2000-10-23 |
2005-01-25 |
Bristol-Myers Squibb Company |
Peptide inhibitors of Hepatitis C virus NS3 protein
|
CZ20032005A3
(en)
|
2001-01-22 |
2004-04-14 |
Merck & Co., Inc. |
Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
|
GB0107924D0
(en)
|
2001-03-29 |
2001-05-23 |
Angeletti P Ist Richerche Bio |
Inhibitor of hepatitis C virus NS3 protease
|
EP1404704B9
(en)
|
2001-07-11 |
2008-02-20 |
Vertex Pharmaceuticals Incorporated |
Bridged bicyclic serine protease inhibitors
|
AU2002348414B2
(en)
|
2001-10-24 |
2009-10-01 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of serine protease, particularly hepatitis C virus NS3-NS4A protease, incorporating a fused ring system
|
AU2003201663A1
(en)
*
|
2002-01-17 |
2003-09-02 |
Amura Therapeutics Limited |
Enzyme substrates for the determination of activity of staphylococcus sp. extracellular protease
|
US7119072B2
(en)
|
2002-01-30 |
2006-10-10 |
Boehringer Ingelheim (Canada) Ltd. |
Macrocyclic peptides active against the hepatitis C virus
|
US6642204B2
(en)
|
2002-02-01 |
2003-11-04 |
Boehringer Ingelheim International Gmbh |
Hepatitis C inhibitor tri-peptides
|
US7091184B2
(en)
|
2002-02-01 |
2006-08-15 |
Boehringer Ingelheim International Gmbh |
Hepatitis C inhibitor tri-peptides
|
NZ575692A
(en)
*
|
2002-04-11 |
2009-10-30 |
Vertex Pharma |
Inhibitors of Serine Proteases, Particularly Hepatitis C Virus NS3-NS4 Protease
|
ES2315568T3
(en)
|
2002-05-20 |
2009-04-01 |
Bristol-Myers Squibb Company |
HEPATITIS C VIRUS INHIBITORS BASED ON P1 'CYCLALKYL SUBSTITUTED.
|
MY140680A
(en)
|
2002-05-20 |
2010-01-15 |
Bristol Myers Squibb Co |
Hepatitis c virus inhibitors
|
ATE503764T1
(en)
|
2002-05-20 |
2011-04-15 |
Bristol Myers Squibb Co |
HEPATITIS C VIRUS INHIBITORS
|
ATE481106T1
(en)
|
2002-05-20 |
2010-10-15 |
Bristol Myers Squibb Co |
HETEROCYCLIC SULFONAMIDE HEPATITIS C VIRUS INHIBITORS
|
US20050075279A1
(en)
|
2002-10-25 |
2005-04-07 |
Boehringer Ingelheim International Gmbh |
Macrocyclic peptides active against the hepatitis C virus
|
WO2004092162A1
(en)
*
|
2003-04-11 |
2004-10-28 |
Vertex Pharmaceuticals, Incorporated |
Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
|
PE20050204A1
(en)
|
2003-05-21 |
2005-05-04 |
Boehringer Ingelheim Int |
INHIBITING COMPOUNDS OF HEPATITIS C
|
UY28500A1
(en)
|
2003-09-05 |
2005-04-29 |
Vertex Pharma |
INHIBITORS OF SERINE PROTEASES, IN PARTICULAR PROTEASA NS3-NS4A HCV.
|
US7642235B2
(en)
|
2003-09-22 |
2010-01-05 |
Boehringer Ingelheim International Gmbh |
Macrocyclic peptides active against the hepatitis C virus
|
CN101857631A
(en)
|
2003-10-10 |
2010-10-13 |
沃泰克斯药物股份有限公司 |
Serine protease, the particularly inhibitor of HCV NS3-NS4A proteolytic enzyme
|
TWI375679B
(en)
|
2003-10-14 |
2012-11-01 |
Hoffmann La Roche |
Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of hcv replication
|
US8187874B2
(en)
|
2003-10-27 |
2012-05-29 |
Vertex Pharmaceuticals Incorporated |
Drug discovery method
|
EP1944042A1
(en)
|
2003-10-27 |
2008-07-16 |
Vertex Pharmceuticals Incorporated |
Combinations for HCV treatment
|
WO2005042570A1
(en)
|
2003-10-27 |
2005-05-12 |
Vertex Pharmaceuticals Incorporated |
Hcv ns3-ns4a protease resistance mutants
|
US7132504B2
(en)
|
2003-11-12 |
2006-11-07 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
US7309708B2
(en)
|
2003-11-20 |
2007-12-18 |
Birstol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
US7135462B2
(en)
|
2003-11-20 |
2006-11-14 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
EP1730167B1
(en)
|
2004-01-21 |
2011-01-12 |
Boehringer Ingelheim International GmbH |
Macrocyclic peptides active against the hepatitis c virus
|
AU2005212257A1
(en)
|
2004-02-04 |
2005-08-25 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
|
US20050182252A1
(en)
|
2004-02-13 |
2005-08-18 |
Reddy K. R. |
Novel 2'-C-methyl nucleoside derivatives
|
ES2322602T3
(en)
|
2004-02-24 |
2009-06-23 |
Japan Tobacco, Inc. |
CONDENSED HETEROTETHYCLIC COMPOUNDS AND ITS USE AS AN HCV POLYMERASE INHIBITOR.
|
US20070049593A1
(en)
|
2004-02-24 |
2007-03-01 |
Japan Tobacco Inc. |
Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor
|
JP5055564B2
(en)
|
2004-06-15 |
2012-10-24 |
メルク・シャープ・エンド・ドーム・コーポレイション |
C-purine nucleoside analogues as inhibitors of RNA-dependent RNA viral polymerase
|
AU2005267421B2
(en)
|
2004-06-24 |
2010-06-03 |
Merck Sharp & Dohme Corp. |
Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection
|
UY29016A1
(en)
|
2004-07-20 |
2006-02-24 |
Boehringer Ingelheim Int |
ANALOGS OF INHIBITING DIPEPTIDES OF HEPATITIS C
|
ES2366478T3
(en)
|
2004-07-20 |
2011-10-20 |
Boehringer Ingelheim International Gmbh |
PEPTIDE ANALOGS INHIBITORS OF HEPATITIS C.
|
KR20070061570A
(en)
|
2004-10-01 |
2007-06-13 |
버텍스 파마슈티칼스 인코포레이티드 |
HCC Ns3-Ns4A protease inhibition
|
US7659263B2
(en)
|
2004-11-12 |
2010-02-09 |
Japan Tobacco Inc. |
Thienopyrrole compound and use thereof as HCV polymerase inhibitor
|
JP4705164B2
(en)
|
2005-05-02 |
2011-06-22 |
メルク・シャープ・エンド・ドーム・コーポレイション |
HCV NS3 protease inhibitor
|
US7470664B2
(en)
|
2005-07-20 |
2008-12-30 |
Merck & Co., Inc. |
HCV NS3 protease inhibitors
|
SG166791A1
(en)
|
2005-07-25 |
2010-12-29 |
Intermune Inc |
Novel macrocyclic inhibitors of hepatitis c virus replication
|
WO2007016441A1
(en)
|
2005-08-01 |
2007-02-08 |
Merck & Co., Inc. |
Macrocyclic peptides as hcv ns3 protease inhibitors
|
CA2617679A1
(en)
|
2005-08-02 |
2007-02-08 |
Steve Lyons |
Inhibitors of serine proteases
|
WO2007021610A2
(en)
|
2005-08-09 |
2007-02-22 |
Merck & Co., Inc. |
Ribonucleoside cyclic acetal derivatives for the treatment of rna-dependent rna viral infection
|
AU2006279357B2
(en)
|
2005-08-19 |
2012-05-31 |
Janssen Pharmaceutica Nv |
Processes and intermediates
|
US8399615B2
(en)
|
2005-08-19 |
2013-03-19 |
Vertex Pharmaceuticals Incorporated |
Processes and intermediates
|
AR055395A1
(en)
|
2005-08-26 |
2007-08-22 |
Vertex Pharma |
INHIBITING COMPOUNDS OF THE ACTIVITY OF SERINA PROTEASA NS3-NS4A OF HEPATITIS C VIRUS
|
EP1999129B1
(en)
|
2005-10-11 |
2010-12-29 |
Intermune, Inc. |
Compounds and methods for inhibiting hepatitis c viral replication
|
NZ568324A
(en)
|
2005-11-11 |
2012-01-12 |
Vertex Pharma |
Hepatitis C virus variants
|
US7705138B2
(en)
|
2005-11-11 |
2010-04-27 |
Vertex Pharmaceuticals Incorporated |
Hepatitis C virus variants
|
US8017612B2
(en)
|
2006-04-18 |
2011-09-13 |
Japan Tobacco Inc. |
Piperazine compound and use thereof as a HCV polymerase inhibitor
|
GB0609492D0
(en)
|
2006-05-15 |
2006-06-21 |
Angeletti P Ist Richerche Bio |
Therapeutic agents
|
GB0612423D0
(en)
|
2006-06-23 |
2006-08-02 |
Angeletti P Ist Richerche Bio |
Therapeutic agents
|
EP1886685A1
(en)
|
2006-08-11 |
2008-02-13 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods, uses and compositions for modulating replication of hcv through the farnesoid x receptor (fxr) activation or inhibition
|
US8377873B2
(en)
|
2006-10-24 |
2013-02-19 |
Merck Sharp & Dohme Corp. |
HCV NS3 protease inhibitors
|
EP2079479B1
(en)
|
2006-10-24 |
2014-11-26 |
Merck Sharp & Dohme Corp. |
Hcv ns3 protease inhibitors
|
AU2007309488B2
(en)
|
2006-10-24 |
2012-10-11 |
Merck Sharp & Dohme Corp. |
HCV NS3 protease inhibitors
|
BRPI0718161A2
(en)
|
2006-10-27 |
2013-11-26 |
Merck & Co Inc |
COMPOUND, PHARMACEUTICAL COMPOSITION, AND, USE OF THE COMPOUND.
|
CN101568346B
(en)
|
2006-10-27 |
2015-11-25 |
默沙东公司 |
HCV NS3 protease inhibitor
|
GB0625349D0
(en)
|
2006-12-20 |
2007-01-31 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
GB0625345D0
(en)
|
2006-12-20 |
2007-01-31 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
AU2007335962B2
(en)
|
2006-12-20 |
2012-09-06 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa |
Antiviral indoles
|
NZ580917A
(en)
|
2007-05-04 |
2012-06-29 |
Vertex Pharma |
Combinations of protease inhibitors such as VX-950 and polymerase inhibitors for the treatment of HCV infection
|
EP2162431B1
(en)
|
2007-06-29 |
2017-06-07 |
Gilead Sciences, Inc. |
Antiviral compounds
|
EP2162432A2
(en)
|
2007-06-29 |
2010-03-17 |
Gilead Sciences, Inc. |
Antiviral compounds
|
CA2693533A1
(en)
|
2007-07-17 |
2009-01-22 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa |
Macrocyclic indole derivatives for the treatment of hepatitis c infections
|
US8927569B2
(en)
|
2007-07-19 |
2015-01-06 |
Merck Sharp & Dohme Corp. |
Macrocyclic compounds as antiviral agents
|
GB0718575D0
(en)
|
2007-09-24 |
2007-10-31 |
Angeletti P Ist Richerche Bio |
Nucleoside derivatives as inhibitors of viral polymerases
|
EP2271345B1
(en)
|
2008-04-28 |
2015-05-20 |
Merck Sharp & Dohme Corp. |
Hcv ns3 protease inhibitors
|
RS53420B
(en)
|
2008-07-22 |
2014-12-31 |
Msd Italia S.R.L. |
Combinations of a macrocyclic quinoxaline compound which is an hcv ns3 protease inhibitor with other hcv agents
|
WO2010082050A1
(en)
|
2009-01-16 |
2010-07-22 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. |
Macrocyclic and 7-aminoalkyl-substituted benzoxazocines for treatment of hepatitis c infections
|
GB0900914D0
(en)
|
2009-01-20 |
2009-03-04 |
Angeletti P Ist Richerche Bio |
Antiviral agents
|
WO2011014487A1
(en)
|
2009-07-30 |
2011-02-03 |
Merck Sharp & Dohme Corp. |
Hepatitis c virus ns3 protease inhibitors
|
HUE030402T2
(en)
|
2009-09-15 |
2017-05-29 |
Taigen Biotechnology Co Ltd |
Hcv protease inhibitors
|
CN102140100B
(en)
|
2010-01-27 |
2014-06-11 |
爱博新药研发(上海)有限公司 |
Polycyclic compound for inhibiting hepatitis C virus efficiently, preparation method thereof and application thereof
|
WO2012107589A1
(en)
|
2011-02-11 |
2012-08-16 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for the treatment and prevention of hcv infections
|
AU2012269643A1
(en)
|
2011-06-16 |
2014-02-06 |
AB Pharma Ltd. |
Macrocyclic heterocyclic compound for inhibiting hepatitis C virus and preparation and use thereof
|
EP2780026B1
(en)
|
2011-11-15 |
2019-10-23 |
Merck Sharp & Dohme Corp. |
Hcv ns3 protease inhibitors
|
WO2013106344A1
(en)
|
2012-01-12 |
2013-07-18 |
Ligand Pharmaceuticals, Inc. |
2 '-c-methyl nucleosides containing a cyclic phosphate diester of 1, 3-propanediol (2-oxo-[1, 3, 2]-dioxaphosphorinane) at position 5'
|
WO2014121418A1
(en)
|
2013-02-07 |
2014-08-14 |
Merck Sharp & Dohme Corp. |
Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c
|
WO2014121417A1
(en)
|
2013-02-07 |
2014-08-14 |
Merck Sharp & Dohme Corp. |
Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c
|
EP2899207A1
(en)
|
2014-01-28 |
2015-07-29 |
Amikana.Biologics |
New method for testing HCV protease inhibition
|
AU2015217221A1
(en)
|
2014-02-13 |
2016-08-11 |
Ligand Pharmaceuticals, Inc. |
Prodrug compounds and their uses
|
EP3164136A4
(en)
|
2014-07-02 |
2018-04-04 |
Ligand Pharmaceuticals, Inc. |
Prodrug compounds and uses therof
|
CA3087932A1
(en)
|
2018-01-09 |
2019-07-18 |
Ligand Pharmaceuticals, Inc. |
Acetal compounds and therapeutic uses thereof
|