WO2011002988A1
(en)
|
2009-07-01 |
2011-01-06 |
Transposagen Biopharmaceuticals, Inc. |
Genetically modified rat models for severe combined immunodeficiency (scid)
|
US10920242B2
(en)
|
2011-02-25 |
2021-02-16 |
Recombinetics, Inc. |
Non-meiotic allele introgression
|
US9528124B2
(en)
|
2013-08-27 |
2016-12-27 |
Recombinetics, Inc. |
Efficient non-meiotic allele introgression
|
AU2012333134B2
(en)
|
2011-07-22 |
2017-05-25 |
John Paul Guilinger |
Evaluation and improvement of nuclease cleavage specificity
|
ES2991004T3
(es)
|
2011-12-22 |
2024-12-02 |
Harvard College |
Métodos para la detección de analitos
|
GB201122458D0
(en)
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
WO2013119602A1
(en)
|
2012-02-06 |
2013-08-15 |
President And Fellows Of Harvard College |
Arrdc1-mediated microvesicles (armms) and uses thereof
|
US9637739B2
(en)
|
2012-03-20 |
2017-05-02 |
Vilnius University |
RNA-directed DNA cleavage by the Cas9-crRNA complex
|
AU2013251558B2
(en)
|
2012-04-25 |
2019-01-03 |
Regeneron Pharmaceuticals, Inc. |
Nuclease-mediated targeting with large targeting vectors
|
EP2841572B1
(en)
|
2012-04-27 |
2019-06-19 |
Duke University |
Genetic correction of mutated genes
|
LT3241902T
(lt)
|
2012-05-25 |
2018-06-25 |
The Regents Of The University Of California |
Būdai ir kompozicijos, skirti rnr nukreiptos tikslinės dnr modifikacijai ir rnr nukreiptos transkripcijos moduliacijai
|
CA2877290A1
(en)
|
2012-06-19 |
2013-12-27 |
Daniel F. Voytas |
Gene targeting in plants using dna viruses
|
HUE041553T2
(hu)
|
2012-07-11 |
2019-05-28 |
Sangamo Therapeutics Inc |
Lizoszomális tárolási betegségek (LSD) kezelése és génterápia
|
US10648001B2
(en)
|
2012-07-11 |
2020-05-12 |
Sangamo Therapeutics, Inc. |
Method of treating mucopolysaccharidosis type I or II
|
EP3494997B1
(en)
*
|
2012-07-25 |
2019-09-18 |
The Broad Institute, Inc. |
Inducible dna binding proteins and genome perturbation tools and applications thereof
|
AU2013335451C1
(en)
*
|
2012-10-23 |
2024-07-04 |
Toolgen Incorporated |
Composition for cleaving a target DNA comprising a guide RNA specific for the target DNA and Cas protein-encoding nucleic acid or Cas protein, and use thereof
|
US10968446B2
(en)
|
2012-11-01 |
2021-04-06 |
Massachusetts Institute Of Technology |
Directed evolution of synthetic gene cluster
|
PL3363902T3
(pl)
|
2012-12-06 |
2020-05-18 |
Sigma-Aldrich Co. Llc |
Modyfikacja i regulacja genomu w oparciu o CRISPR
|
JP2016505256A
(ja)
|
2012-12-12 |
2016-02-25 |
ザ・ブロード・インスティテュート・インコーポレイテッ |
配列操作のためのCRISPR−Cas成分系、方法および組成物
|
EP3702463A1
(en)
|
2012-12-12 |
2020-09-02 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions for sequence manipulation
|
WO2014093709A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
WO2014093655A2
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
|
EP2898075B1
(en)
|
2012-12-12 |
2016-03-09 |
The Broad Institute, Inc. |
Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
KR20150105956A
(ko)
|
2012-12-12 |
2015-09-18 |
더 브로드 인스티튜트, 인코퍼레이티드 |
서열 조작 및 치료적 적용을 위한 시스템, 방법 및 조성물의 전달, 유전자 조작 및 최적화
|
ES2741951T3
(es)
*
|
2012-12-17 |
2020-02-12 |
Harvard College |
Modificación por ingeniería genética del genoma humano guiada por ARN
|
AU2014207618A1
(en)
|
2013-01-16 |
2015-08-06 |
Emory University |
Cas9-nucleic acid complexes and uses related thereto
|
US10660943B2
(en)
*
|
2013-02-07 |
2020-05-26 |
The Rockefeller University |
Sequence specific antimicrobials
|
US11135273B2
(en)
|
2013-02-07 |
2021-10-05 |
The Rockefeller University |
Sequence specific antimicrobials
|
EP3578666A1
(en)
|
2013-03-12 |
2019-12-11 |
President and Fellows of Harvard College |
Method of generating a three-dimensional nucleic acid containing matrix
|
KR101780885B1
(ko)
|
2013-03-14 |
2017-10-11 |
카리부 바이오사이언시스 인코포레이티드 |
핵산-표적화 핵산의 조성물 및 방법
|
US10760064B2
(en)
|
2013-03-15 |
2020-09-01 |
The General Hospital Corporation |
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
EP3988667A1
(en)
|
2013-03-15 |
2022-04-27 |
The General Hospital Corporation |
Using truncated guide rnas (tru-grnas) to increase specificity for rna-guided genome editing
|
US9234213B2
(en)
|
2013-03-15 |
2016-01-12 |
System Biosciences, Llc |
Compositions and methods directed to CRISPR/Cas genomic engineering systems
|
US20140364333A1
(en)
*
|
2013-03-15 |
2014-12-11 |
President And Fellows Of Harvard College |
Methods for Live Imaging of Cells
|
US9828582B2
(en)
|
2013-03-19 |
2017-11-28 |
Duke University |
Compositions and methods for the induction and tuning of gene expression
|
EP2981617B1
(en)
|
2013-04-04 |
2023-07-05 |
President and Fellows of Harvard College |
Therapeutic uses of genome editing with crispr/cas systems
|
PT2986729T
(pt)
|
2013-04-16 |
2018-11-30 |
Regeneron Pharma |
Modificação alvejada do genoma de rato
|
AU2014273082B2
(en)
*
|
2013-05-29 |
2018-11-08 |
Cellectis |
A method for producing precise DNA cleavage using Cas9 nickase activity
|
US11414695B2
(en)
|
2013-05-29 |
2022-08-16 |
Agilent Technologies, Inc. |
Nucleic acid enrichment using Cas9
|
US9267135B2
(en)
|
2013-06-04 |
2016-02-23 |
President And Fellows Of Harvard College |
RNA-guided transcriptional regulation
|
KR102282990B1
(ko)
*
|
2013-06-04 |
2021-07-28 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
Rna-가이드된 전사 조절
|
EP4435110A3
(en)
*
|
2013-06-05 |
2025-01-01 |
Duke University |
Rna-guided gene editing and gene regulation
|
WO2014201015A2
(en)
|
2013-06-11 |
2014-12-18 |
The Regents Of The University Of California |
Methods and compositions for target dna modification
|
CN106062197A
(zh)
|
2013-06-17 |
2016-10-26 |
布罗德研究所有限公司 |
用于序列操纵的串联指导系统、方法和组合物的递送、工程化和优化
|
KR20160034901A
(ko)
|
2013-06-17 |
2016-03-30 |
더 브로드 인스티튜트, 인코퍼레이티드 |
서열 조작에 최적화된 crispr-cas 이중 닉카아제 시스템, 방법 및 조성물
|
JP6702858B2
(ja)
|
2013-06-17 |
2020-06-03 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
ウイルス成分を使用して障害および疾患をターゲティングするためのCRISPR−Cas系および組成物の送達、使用および治療上の適用
|
EP3011031B1
(en)
|
2013-06-17 |
2020-09-30 |
The Broad Institute Inc. |
Delivery and use of the crispr-cas systems, vectors and compositions for hepatic targeting and therapy
|
EP3011033B1
(en)
|
2013-06-17 |
2020-02-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
US10011850B2
(en)
|
2013-06-21 |
2018-07-03 |
The General Hospital Corporation |
Using RNA-guided FokI Nucleases (RFNs) to increase specificity for RNA-Guided Genome Editing
|
EP3019595A4
(en)
|
2013-07-09 |
2016-11-30 |
|
THERAPEUTIC USES OF A GENERIC CHANGE WITH CRISPR / CAS SYSTEMS
|
US9163284B2
(en)
|
2013-08-09 |
2015-10-20 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a Cas9 nuclease
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
AU2014308900A1
(en)
|
2013-08-22 |
2016-03-10 |
E. I. Du Pont De Nemours And Company |
A soybean U6 polymerase III promoter and methods of use
|
US10760065B2
(en)
|
2013-09-05 |
2020-09-01 |
Massachusetts Institute Of Technology |
Tuning microbial populations with programmable nucleases
|
US9340800B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
Extended DNA-sensing GRNAS
|
US9322037B2
(en)
|
2013-09-06 |
2016-04-26 |
President And Fellows Of Harvard College |
Cas9-FokI fusion proteins and uses thereof
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
TW201542816A
(zh)
*
|
2013-09-18 |
2015-11-16 |
Kymab Ltd |
方法、細胞與生物體
|
WO2015054507A1
(en)
|
2013-10-10 |
2015-04-16 |
Pronutria, Inc. |
Nutritive polypeptide production systems, and methods of manufacture and use thereof
|
WO2015065964A1
(en)
|
2013-10-28 |
2015-05-07 |
The Broad Institute Inc. |
Functional genomics using crispr-cas systems, compositions, methods, screens and applications thereof
|
KR102523466B1
(ko)
|
2013-11-07 |
2023-04-20 |
에디타스 메디신, 인코포레이티드 |
지배적인 gRNA를 이용하는 CRISPR-관련 방법 및 조성물
|
US11326209B2
(en)
|
2013-11-07 |
2022-05-10 |
Massachusetts Institute Of Technology |
Cell-based genomic recorded accumulative memory
|
RU2725520C2
(ru)
|
2013-12-11 |
2020-07-02 |
Регенерон Фармасьютикалс, Инк. |
Способы и композиции для направленной модификации генома
|
MX2016007326A
(es)
|
2013-12-12 |
2017-02-13 |
Broad Inst Inc |
Composiciones y metodos de uso de sistemas crispr-cas en desordenes debidos a repeticion de nucleotidos.
|
CA2932475A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components
|
JP6793547B2
(ja)
|
2013-12-12 |
2020-12-02 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
最適化機能CRISPR−Cas系による配列操作のための系、方法および組成物
|
AU2014361784A1
(en)
|
2013-12-12 |
2016-06-23 |
Massachusetts Institute Of Technology |
Delivery, use and therapeutic applications of the CRISPR-Cas systems and compositions for HBV and viral diseases and disorders
|
US11053481B2
(en)
|
2013-12-12 |
2021-07-06 |
President And Fellows Of Harvard College |
Fusions of Cas9 domains and nucleic acid-editing domains
|
MX2016007328A
(es)
|
2013-12-12 |
2017-07-19 |
Broad Inst Inc |
Suministro, uso y aplicaciones terapeuticas de sistemas y composiciones crispr-cas para edicion del genoma.
|
EP3835419A1
(en)
|
2013-12-12 |
2021-06-16 |
The Regents of The University of California |
Methods and compositions for modifying a single stranded target nucleic acid
|
EP4219699A1
(en)
|
2013-12-12 |
2023-08-02 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
|
WO2015089364A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crystal structure of a crispr-cas system, and uses thereof
|
CA3225456A1
(en)
|
2013-12-19 |
2015-06-25 |
Novartis Ag |
Human mesothelin chimeric antigen receptors and uses thereof
|
EP3089989B1
(en)
|
2013-12-31 |
2020-06-24 |
The Regents of The University of California |
Cas9 crystals and methods of use thereof
|
MX2016010285A
(es)
|
2014-02-11 |
2017-01-11 |
Univ Colorado Regents |
Ingenieria genetica multiplexada habilitada por crispr.
|
SG11201606819QA
(en)
|
2014-02-18 |
2016-09-29 |
Univ Duke |
Compositions for the inactivation of virus replication and methods of making and using the same
|
WO2015130968A2
(en)
|
2014-02-27 |
2015-09-03 |
The Broad Institute Inc. |
T cell balance gene expression, compositions of matters and methods of use thereof
|
WO2015131101A1
(en)
|
2014-02-27 |
2015-09-03 |
Monsanto Technology Llc |
Compositions and methods for site directed genomic modification
|
ES2752175T3
(es)
|
2014-03-05 |
2020-04-03 |
Univ Kobe Nat Univ Corp |
Método de modificación de la secuencia genómica para convertir específicamente bases de ácido nucleico de una secuencia de ADN seleccionada como diana, y complejo molecular para su uso en el mismo
|
US11028388B2
(en)
|
2014-03-05 |
2021-06-08 |
Editas Medicine, Inc. |
CRISPR/Cas-related methods and compositions for treating Usher syndrome and retinitis pigmentosa
|
US11141493B2
(en)
|
2014-03-10 |
2021-10-12 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
DK3116997T3
(da)
|
2014-03-10 |
2019-08-19 |
Editas Medicine Inc |
Crispr/cas-relaterede fremgangsmåder og sammensætninger til behandling af lebers kongenitale amaurose 10 (lca10)
|
US11339437B2
(en)
|
2014-03-10 |
2022-05-24 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
CN106163547A
(zh)
|
2014-03-15 |
2016-11-23 |
诺华股份有限公司 |
使用嵌合抗原受体治疗癌症
|
WO2015148761A1
(en)
|
2014-03-26 |
2015-10-01 |
University Of Maryland, College Park |
Targeted genome editing in zygotes of domestic large animals
|
EP3122880B1
(en)
|
2014-03-26 |
2021-05-05 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating sickle cell disease
|
US20170029850A1
(en)
*
|
2014-04-02 |
2017-02-02 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating primary open angle glaucoma
|
AU2015244039B2
(en)
|
2014-04-07 |
2021-10-21 |
Novartis Ag |
Treatment of cancer using anti-CD19 chimeric antigen receptor
|
CA2945573A1
(en)
*
|
2014-04-14 |
2015-10-22 |
Yoshikazu Mikawa |
Crispr systems for antibiotic-resistant microorganisms
|
GB201406968D0
(en)
|
2014-04-17 |
2014-06-04 |
Green Biologics Ltd |
Deletion mutants
|
GB201406970D0
(en)
*
|
2014-04-17 |
2014-06-04 |
Green Biologics Ltd |
Targeted mutations
|
MX2016014066A
(es)
|
2014-04-28 |
2017-05-03 |
Recombinetics Inc |
Edicion de genes multiples en cerdos.
|
CA2948429A1
(en)
|
2014-05-09 |
2015-11-12 |
Universite Laval |
Prevention and treatment of alzheimer's disease by genome editing using the crispr/cas system
|
NZ725600A
(en)
|
2014-05-19 |
2023-09-29 |
Pfizer |
Substituted-6,8-dioxabicyclo[3.2.1]octane-2,3-diol compounds as targeting agents of asgpr
|
CA2952121A1
(en)
|
2014-06-13 |
2015-12-17 |
Childrens' Medical Center Corporation |
Products and methods to isolate mitochondria
|
KR102598819B1
(ko)
|
2014-06-23 |
2023-11-03 |
더 제너럴 하스피탈 코포레이션 |
서열결정에 의해 평가된 DSB의 게놈 전체에 걸친 비편향된 확인 (GUIDE-Seq)
|
CN106795524A
(zh)
*
|
2014-07-11 |
2017-05-31 |
先锋国际良种公司 |
使用向导rna/cas内切核酸酶系统改变农学性状及其使用方法
|
US10676754B2
(en)
|
2014-07-11 |
2020-06-09 |
E I Du Pont De Nemours And Company |
Compositions and methods for producing plants resistant to glyphosate herbicide
|
WO2016011203A1
(en)
|
2014-07-15 |
2016-01-21 |
Life Technologies Corporation |
Compositions with lipid aggregates and methods for efficient delivery of molecules to cells
|
KR102612313B1
(ko)
|
2014-07-21 |
2023-12-12 |
노파르티스 아게 |
인간화 항-bcma 키메라 항원 수용체를 사용한 암의 치료
|
RU2747384C2
(ru)
|
2014-07-21 |
2021-05-04 |
Новартис Аг |
Лечение рака с помощью химерного антигенного рецептора к cd33
|
US11542488B2
(en)
|
2014-07-21 |
2023-01-03 |
Novartis Ag |
Sortase synthesized chimeric antigen receptors
|
WO2016014530A1
(en)
|
2014-07-21 |
2016-01-28 |
Novartis Ag |
Combinations of low, immune enhancing. doses of mtor inhibitors and cars
|
AU2015298571B2
(en)
|
2014-07-30 |
2020-09-03 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
ES2781175T3
(es)
|
2014-07-31 |
2020-08-31 |
Novartis Ag |
Subconjunto optimizado de células T que contienen un receptor de antígeno quimérico
|
US10513711B2
(en)
|
2014-08-13 |
2019-12-24 |
Dupont Us Holding, Llc |
Genetic targeting in non-conventional yeast using an RNA-guided endonuclease
|
CA2958200A1
(en)
|
2014-08-14 |
2016-02-18 |
Novartis Ag |
Treatment of cancer using a gfr alpha-4 chimeric antigen receptor
|
DK3180426T3
(da)
|
2014-08-17 |
2020-03-30 |
Broad Inst Inc |
Genomredigering ved anvendelse af cas9-nickaser
|
TWI719946B
(zh)
|
2014-08-19 |
2021-03-01 |
瑞士商諾華公司 |
使用cd123嵌合抗原受體治療癌症
|
NZ728437A
(en)
*
|
2014-08-27 |
2018-02-23 |
Caribou Biosciences Inc |
Methods for increasing cas9-mediated engineering efficiency
|
US10450584B2
(en)
|
2014-08-28 |
2019-10-22 |
North Carolina State University |
Cas9 proteins and guiding features for DNA targeting and genome editing
|
US10570418B2
(en)
|
2014-09-02 |
2020-02-25 |
The Regents Of The University Of California |
Methods and compositions for RNA-directed target DNA modification
|
EP3628739B1
(en)
|
2014-09-12 |
2024-05-01 |
Corteva Agriscience LLC |
Generation of site-specific-integration sites for complex trait loci in corn and soybean, and methods of use
|
JP6839074B2
(ja)
|
2014-09-17 |
2021-03-03 |
ノバルティス アーゲー |
養子免疫療法のためのキメラ受容体での細胞毒性細胞のターゲティング
|
US9616114B1
(en)
|
2014-09-18 |
2017-04-11 |
David Gordon Bermudes |
Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
|
AU2015320738B2
(en)
|
2014-09-23 |
2021-12-02 |
Acceligen, Inc. |
Materials and methods for producing animals with short hair
|
WO2016049251A1
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling mutations in leukocytes
|
WO2016049163A2
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Use and production of chd8+/- transgenic animals with behavioral phenotypes characteristic of autism spectrum disorder
|
WO2016049024A2
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling competition of multiple cancer mutations in vivo
|
WO2016049258A2
(en)
|
2014-09-25 |
2016-03-31 |
The Broad Institute Inc. |
Functional screening with optimized functional crispr-cas systems
|
US10040048B1
(en)
|
2014-09-25 |
2018-08-07 |
Synthego Corporation |
Automated modular system and method for production of biopolymers
|
WO2016057961A1
(en)
|
2014-10-10 |
2016-04-14 |
Editas Medicine, Inc. |
Compositions and methods for promoting homology directed repair
|
WO2016061073A1
(en)
*
|
2014-10-14 |
2016-04-21 |
Memorial Sloan-Kettering Cancer Center |
Composition and method for in vivo engineering of chromosomal rearrangements
|
CN105602935B
(zh)
*
|
2014-10-20 |
2020-11-13 |
聂凌云 |
一种新型线粒体基因组编辑工具
|
GB201418965D0
(da)
|
2014-10-24 |
2014-12-10 |
Ospedale San Raffaele And Fond Telethon |
|
US20170247762A1
(en)
|
2014-10-27 |
2017-08-31 |
The Board Institute Inc. |
Compositions, methods and use of synthetic lethal screening
|
US9816080B2
(en)
*
|
2014-10-31 |
2017-11-14 |
President And Fellows Of Harvard College |
Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs)
|
WO2016073955A2
(en)
|
2014-11-06 |
2016-05-12 |
President And Fellows Of Harvard College |
Cells lacking b2m surface expression and methods for allogeneic administration of such cells
|
US10208298B2
(en)
|
2014-11-06 |
2019-02-19 |
E.I. Du Pont De Nemours And Company |
Peptide-mediated delivery of RNA-guided endonuclease into cells
|
CA2963820A1
(en)
|
2014-11-07 |
2016-05-12 |
Editas Medicine, Inc. |
Methods for improving crispr/cas-mediated genome-editing
|
CA3176380A1
(en)
|
2014-11-21 |
2016-05-26 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for targeted genetic modification using paired guide rnas
|
US11168369B2
(en)
|
2014-11-25 |
2021-11-09 |
The Brigham And Women's Hospital, Inc. |
Method of identifying and treating a person having a predisposition to or afflicted with a cardiometabolic disease
|
US20180057839A1
(en)
|
2014-11-26 |
2018-03-01 |
The Regents Of The University Of California |
Therapeutic compositions comprising transcription factors and methods of making and using the same
|
GB201421096D0
(en)
|
2014-11-27 |
2015-01-14 |
Imp Innovations Ltd |
Genome editing methods
|
WO2016082135A1
(zh)
*
|
2014-11-27 |
2016-06-02 |
中国农业科学院北京畜牧兽医研究所 |
一种利用定点切割系统对猪h11位点定点插入的方法
|
AU2015355546B2
(en)
|
2014-12-03 |
2021-10-14 |
Agilent Technologies, Inc. |
Guide RNA with chemical modifications
|
JP6830437B2
(ja)
|
2014-12-10 |
2021-02-17 |
リージェンツ オブ ザ ユニバーシティ オブ ミネソタ |
疾患を処置するための遺伝子改変された細胞、組織および臓器
|
EP3889260A1
(en)
|
2014-12-12 |
2021-10-06 |
The Broad Institute, Inc. |
Protected guide rnas (pgrnas)
|
WO2016094874A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Escorted and functionalized guides for crispr-cas systems
|
EP3230452A1
(en)
|
2014-12-12 |
2017-10-18 |
The Broad Institute Inc. |
Dead guides for crispr transcription factors
|
WO2016094880A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of crispr systems and compositions for genome editing as to hematopoietic stem cells (hscs)
|
US20170327834A1
(en)
|
2014-12-15 |
2017-11-16 |
Syngenta Participations Ag |
Pesticidal microrna carriers and use thereof
|
AU2015362784B2
(en)
*
|
2014-12-16 |
2021-05-13 |
Danisco Us Inc |
Fungal genome modification systems and methods of use
|
BR112017012765A2
(pt)
*
|
2014-12-17 |
2018-01-16 |
Du Pont |
?métodos para editar uma sequência de nucleotídeos, célula e linhagem de e. coli e método para produzir uma célula de e. coli?
|
US20190054117A1
(en)
|
2014-12-19 |
2019-02-21 |
Novartis Ag |
Dimerization switches and uses thereof
|
WO2016100974A1
(en)
|
2014-12-19 |
2016-06-23 |
The Broad Institute Inc. |
Unbiased identification of double-strand breaks and genomic rearrangement by genome-wide insert capture sequencing
|
US10190106B2
(en)
|
2014-12-22 |
2019-01-29 |
Univesity Of Massachusetts |
Cas9-DNA targeting unit chimeras
|
WO2016106236A1
(en)
|
2014-12-23 |
2016-06-30 |
The Broad Institute Inc. |
Rna-targeting system
|
CA2969151A1
(en)
|
2014-12-23 |
2016-06-30 |
Syngenta Participations Ag |
Methods and compositions for identifying and enriching for cells comprising site specific genomic modifications
|
EP3237615B2
(en)
|
2014-12-24 |
2023-07-26 |
The Broad Institute, Inc. |
Crispr having or associated with destabilization domains
|
WO2016108926A1
(en)
|
2014-12-30 |
2016-07-07 |
The Broad Institute Inc. |
Crispr mediated in vivo modeling and genetic screening of tumor growth and metastasis
|
JP2018500037A
(ja)
|
2014-12-31 |
2018-01-11 |
シンセティック ジェノミクス インコーポレーテッド |
高効率なインビボゲノム編集のための組成物及び方法
|
WO2016114972A1
(en)
|
2015-01-12 |
2016-07-21 |
The Regents Of The University Of California |
Heterodimeric cas9 and methods of use thereof
|
US11180792B2
(en)
|
2015-01-28 |
2021-11-23 |
The Regents Of The University Of California |
Methods and compositions for labeling a single-stranded target nucleic acid
|
LT3250691T
(lt)
|
2015-01-28 |
2023-09-11 |
Caribou Biosciences, Inc. |
Crispr hibridiniai dnr/rnr polinukleotidai ir naudojimo būdai
|
JP6929791B2
(ja)
|
2015-02-09 |
2021-09-01 |
デューク ユニバーシティ |
エピゲノム編集のための組成物および方法
|
EP3262193A2
(en)
|
2015-02-26 |
2018-01-03 |
The Broad Institute Inc. |
T cell balance gene expression, compositions of matters and methods of use thereof
|
EP3265560B1
(en)
|
2015-03-02 |
2021-12-08 |
Sinai Health System |
Homologous recombination factors
|
AU2016226077B2
(en)
|
2015-03-03 |
2021-12-23 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases with altered PAM specificity
|
CN104673816A
(zh)
*
|
2015-03-05 |
2015-06-03 |
广东医学院 |
一种pCr-NHEJ载体及其构建方法及其用于细菌基因定点敲除的应用
|
CN107567499A
(zh)
|
2015-03-27 |
2018-01-09 |
纳幕尔杜邦公司 |
大豆u6核小rna基因启动子及其在植物小rna基因的组成型表达中的用途
|
CN107787367B
(zh)
|
2015-04-06 |
2021-10-26 |
里兰斯坦福初级大学理事会 |
用于crispr/cas介导的基因调控的化学修饰的引导rna
|
US11267874B2
(en)
*
|
2015-04-16 |
2022-03-08 |
President And Fellows Of Harvard College |
Sensor systems for target ligands and uses thereof
|
GB201506509D0
(en)
|
2015-04-16 |
2015-06-03 |
Univ Wageningen |
Nuclease-mediated genome editing
|
EP3286211A1
(en)
|
2015-04-23 |
2018-02-28 |
Novartis AG |
Treatment of cancer using chimeric antigen receptor and protein kinase a blocker
|
KR102535217B1
(ko)
|
2015-04-24 |
2023-05-19 |
에디타스 메디신, 인코포레이티드 |
Cas9 분자/가이드 rna 분자 복합체의 평가
|
EP3289104B1
(en)
|
2015-04-29 |
2020-11-04 |
New York University |
Method for treating high-grade gliomas
|
CN106191040B
(zh)
*
|
2015-04-30 |
2021-09-14 |
杭州菁因康生物科技有限公司 |
基因打靶方法
|
EP3291679B1
(en)
|
2015-05-06 |
2021-12-15 |
SNIPR Technologies Limited |
Altering microbial populations & modifying microbiota
|
CN107921148A
(zh)
|
2015-05-08 |
2018-04-17 |
哈佛学院校长同事会 |
通用供体干细胞和相关方法
|
WO2016182893A1
(en)
|
2015-05-08 |
2016-11-17 |
Teh Broad Institute Inc. |
Functional genomics using crispr-cas systems for saturating mutagenesis of non-coding elements, compositions, methods, libraries and applications thereof
|
CA2986310A1
(en)
|
2015-05-11 |
2016-11-17 |
Editas Medicine, Inc. |
Optimized crispr/cas9 systems and methods for gene editing in stem cells
|
US20180291372A1
(en)
*
|
2015-05-14 |
2018-10-11 |
Massachusetts Institute Of Technology |
Self-targeting genome editing system
|
BR112017024534A2
(pt)
|
2015-05-15 |
2018-07-24 |
Pioneer Hi Bred Int |
sistemas de rna-guia/endonuclease cas9 inovadores
|
WO2016187904A1
(zh)
*
|
2015-05-22 |
2016-12-01 |
深圳市第二人民医院 |
CRISPR-Cas9特异性敲除猪CMAH基因的方法及用于特异性靶向CMAH基因的sgRNA
|
EP3302575A4
(en)
*
|
2015-05-28 |
2019-01-16 |
Coda Biotherapeutics |
GEMONEDITIERUNGSVEKTOREN
|
EA201792663A1
(ru)
*
|
2015-05-29 |
2018-04-30 |
Норт Каролина Стейт Юниверсити |
Способы скрининга бактерий, архей, водорослей и дрожжей с использованием нуклеиновых кислот crispr
|
WO2016196655A1
(en)
|
2015-06-03 |
2016-12-08 |
The Regents Of The University Of California |
Cas9 variants and methods of use thereof
|
WO2016196887A1
(en)
|
2015-06-03 |
2016-12-08 |
Board Of Regents Of The University Of Nebraska |
Dna editing using single-stranded dna
|
EP3302525A2
(en)
|
2015-06-05 |
2018-04-11 |
Novartis AG |
Methods and compositions for diagnosing, treating, and monitoring treatment of shank3 deficiency associated disorders
|
WO2016201047A1
(en)
|
2015-06-09 |
2016-12-15 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for improving transplantation
|
CA2988585A1
(en)
|
2015-06-10 |
2016-12-15 |
Raghu Kalluri |
Use of exosomes for the treatment of disease
|
WO2016198500A1
(en)
*
|
2015-06-10 |
2016-12-15 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and compositions for rna-guided treatment of human cytomegalovirus (hcmv) infection
|
WO2016200263A1
(en)
*
|
2015-06-12 |
2016-12-15 |
Erasmus University Medical Center Rotterdam |
New crispr assays
|
CA2989858A1
(en)
|
2015-06-17 |
2016-12-22 |
The Uab Research Foundation |
Crispr/cas9 complex for introducing a functional polypeptide into cells of blood cell lineage
|
JP2018518182A
(ja)
|
2015-06-17 |
2018-07-12 |
ザ ユーエービー リサーチ ファンデーション |
ゲノム編集のためのcrispr/cas9複合体
|
WO2016205728A1
(en)
|
2015-06-17 |
2016-12-22 |
Massachusetts Institute Of Technology |
Crispr mediated recording of cellular events
|
WO2016205745A2
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Cell sorting
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
FI3430134T3
(fi)
|
2015-06-18 |
2023-01-13 |
|
Uusia CRISPR-entsyymejä ja järjestelmiä
|
US9790490B2
(en)
*
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
EP3436575A1
(en)
|
2015-06-18 |
2019-02-06 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
US10648020B2
(en)
|
2015-06-18 |
2020-05-12 |
The Broad Institute, Inc. |
CRISPR enzymes and systems
|
KR102575342B1
(ko)
|
2015-06-18 |
2023-09-05 |
더 브로드 인스티튜트, 인코퍼레이티드 |
표적외 효과를 감소시키는 crispr 효소 돌연변이
|
CA2990699A1
(en)
|
2015-06-29 |
2017-01-05 |
Ionis Pharmaceuticals, Inc. |
Modified crispr rna and modified single crispr rna and uses thereof
|
KR20230152796A
(ko)
|
2015-07-13 |
2023-11-03 |
피벗 바이오, 인크. |
식물 형질 개선을 위한 방법 및 조성물
|
JP7044373B2
(ja)
|
2015-07-15 |
2022-03-30 |
ラトガース,ザ ステート ユニバーシティ オブ ニュージャージー |
ヌクレアーゼ非依存的な標的化遺伝子編集プラットフォームおよびその用途
|
US10676735B2
(en)
|
2015-07-22 |
2020-06-09 |
Duke University |
High-throughput screening of regulatory element function with epigenome editing technologies
|
JP7409773B2
(ja)
|
2015-07-31 |
2024-01-09 |
リージェンツ オブ ザ ユニバーシティ オブ ミネソタ |
改変された細胞および治療の方法
|
US9580727B1
(en)
|
2015-08-07 |
2017-02-28 |
Caribou Biosciences, Inc. |
Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides
|
WO2017027392A1
(en)
|
2015-08-07 |
2017-02-16 |
Novartis Ag |
Treatment of cancer using chimeric cd3 receptor proteins
|
WO2017027810A2
(en)
|
2015-08-12 |
2017-02-16 |
The General Hospital Corporation |
Compositions and methods that promote hypoxia or the hypoxia response for treatment and prevention of mitochondrial dysfunction and oxidative stress disorders
|
JP2018529759A
(ja)
|
2015-08-14 |
2018-10-11 |
ザ ユニバーシティー オブ シドニー |
治療用コネキシン45阻害剤
|
US11214800B2
(en)
|
2015-08-18 |
2022-01-04 |
The Broad Institute, Inc. |
Methods and compositions for altering function and structure of chromatin loops and/or domains
|
EP4345454A3
(en)
|
2015-08-25 |
2024-07-17 |
Duke University |
Compositions and methods of improving specificity in genomic engineering using rna-guided endonucleases
|
US9926546B2
(en)
|
2015-08-28 |
2018-03-27 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
JP6799586B2
(ja)
|
2015-08-28 |
2020-12-16 |
ザ ジェネラル ホスピタル コーポレイション |
遺伝子操作CRISPR−Cas9ヌクレアーゼ
|
US9512446B1
(en)
|
2015-08-28 |
2016-12-06 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
BR112018004636A2
(pt)
|
2015-09-09 |
2018-10-30 |
National University Corporation Kobe University |
método para modificação de um sítio alvejado em um dna de fita dupla de uma bactéria gram-positiva, complexo de enzima modificadora de ácido nucleico, e, ácido nucleico
|
IL241462A0
(en)
|
2015-09-10 |
2015-11-30 |
Yeda Res & Dev |
Heterologous engineering of betalain pigments in plants
|
AU2016319110B2
(en)
|
2015-09-11 |
2022-01-27 |
The General Hospital Corporation |
Full interrogation of nuclease DSBs and sequencing (FIND-seq)
|
EP3353296B1
(en)
|
2015-09-24 |
2020-11-04 |
Editas Medicine, Inc. |
Use of exonucleases to improve crispr/cas-mediated genome editing
|
CA3000762A1
(en)
|
2015-09-30 |
2017-04-06 |
The General Hospital Corporation |
Comprehensive in vitro reporting of cleavage events by sequencing (circle-seq)
|
BR112018006800A2
(pt)
|
2015-10-05 |
2018-10-23 |
Massachusetts Inst Technology |
fixação de nitrogênio usando agrupamento (cluster)s nif reestruturados
|
WO2017069958A2
(en)
|
2015-10-09 |
2017-04-27 |
The Brigham And Women's Hospital, Inc. |
Modulation of novel immune checkpoint targets
|
AU2016338785B2
(en)
|
2015-10-12 |
2022-07-14 |
E. I. Du Pont De Nemours And Company |
Protected DNA templates for gene modification and increased homologous recombination in cells and methods of use
|
WO2017066497A2
(en)
|
2015-10-13 |
2017-04-20 |
Duke University |
Genome engineering with type i crispr systems in eukaryotic cells
|
EP3362561A2
(en)
|
2015-10-16 |
2018-08-22 |
Astrazeneca AB |
Inducible modification of a cell genome
|
US10968253B2
(en)
|
2015-10-20 |
2021-04-06 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Methods and products for genetic engineering
|
AU2016341041A1
(en)
|
2015-10-20 |
2018-03-15 |
Pioneer Hi-Bred International, Inc. |
Methods and compositions for marker-free genome modification
|
CA3024543A1
(en)
|
2015-10-22 |
2017-04-27 |
The Broad Institute, Inc. |
Type vi-b crispr enzymes and systems
|
WO2017070598A1
(en)
|
2015-10-23 |
2017-04-27 |
Caribou Biosciences, Inc. |
Engineered crispr class 2 cross-type nucleic-acid targeting nucleic acids
|
EP3365357B1
(en)
|
2015-10-23 |
2024-02-14 |
President and Fellows of Harvard College |
Evolved cas9 proteins for gene editing
|
WO2017074788A1
(en)
|
2015-10-27 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for targeting cancer-specific sequence variations
|
WO2017075451A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1
|
WO2017075294A1
(en)
|
2015-10-28 |
2017-05-04 |
The Board Institute Inc. |
Assays for massively combinatorial perturbation profiling and cellular circuit reconstruction
|
EP3368689B1
(en)
|
2015-10-28 |
2020-06-17 |
The Broad Institute, Inc. |
Composition for modulating immune responses by use of immune cell gene signature
|
WO2017075465A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3
|
WO2017075265A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute, Inc. |
Multiplex analysis of single cell constituents
|
AU2016349288A1
(en)
|
2015-11-03 |
2018-05-31 |
President And Fellows Of Harvard College |
Method and apparatus for volumetric imaging of a three-dimensional nucleic acid containing matrix
|
WO2017079724A1
(en)
*
|
2015-11-06 |
2017-05-11 |
The Jackson Laboratory |
Large genomic dna knock-in and uses thereof
|
CA2947904A1
(en)
*
|
2015-11-12 |
2017-05-12 |
Pfizer Inc. |
Tissue-specific genome engineering using crispr-cas9
|
JP6929865B2
(ja)
|
2015-11-13 |
2021-09-01 |
タラ ムーア |
角膜ジストロフィーの治療方法
|
WO2017083766A1
(en)
*
|
2015-11-13 |
2017-05-18 |
Massachusetts Institute Of Technology |
High-throughput crispr-based library screening
|
BR112018009954A2
(pt)
|
2015-11-16 |
2018-11-13 |
Res Inst Nationwide Childrens Hospital |
materiais e métodos para o tratamento de miopatias baseadas em titinas e outras titinopatias
|
WO2017087708A1
(en)
|
2015-11-19 |
2017-05-26 |
The Brigham And Women's Hospital, Inc. |
Lymphocyte antigen cd5-like (cd5l)-interleukin 12b (p40) heterodimers in immunity
|
ES2914623T3
(es)
|
2015-11-27 |
2022-06-14 |
Univ Kobe Nat Univ Corp |
Método para convertir una secuencia genómica de una planta monocotiledónea en la que una base de ácido nucleico en la secuencia de ADN diana se convierte de manera específica y el complejo molecular utilizado en el mismo
|
EP3397260A4
(en)
|
2015-11-30 |
2019-10-16 |
Flagship Pioneering Innovations V, Inc. |
METHODS AND COMPOSITIONS RELATING TO CHOOSERISMS FROM BLOOD PRODUCTS
|
CA3001623A1
(en)
|
2015-11-30 |
2017-06-08 |
Duke University |
Therapeutic targets for the correction of the human dystrophin gene by gene editing and methods of use
|
CN105296518A
(zh)
*
|
2015-12-01 |
2016-02-03 |
中国农业大学 |
一种用于CRISPR/Cas9技术的同源臂载体构建方法
|
AU2016363024B2
(en)
|
2015-12-04 |
2020-01-30 |
Caribou Biosciences, Inc. |
Engineered nucleic-acid targeting nucleic acids
|
US9988624B2
(en)
|
2015-12-07 |
2018-06-05 |
Zymergen Inc. |
Microbial strain improvement by a HTP genomic engineering platform
|
CA3007635A1
(en)
|
2015-12-07 |
2017-06-15 |
Zymergen Inc. |
Promoters from corynebacterium glutamicum
|
US11208649B2
(en)
|
2015-12-07 |
2021-12-28 |
Zymergen Inc. |
HTP genomic engineering platform
|
EP3387134B1
(en)
|
2015-12-11 |
2020-10-14 |
Danisco US Inc. |
Methods and compositions for enhanced nuclease-mediated genome modification and reduced off-target site effects
|
WO2017106657A1
(en)
|
2015-12-18 |
2017-06-22 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
EP3708665A1
(en)
|
2015-12-18 |
2020-09-16 |
Danisco US Inc. |
Methods and compositions for t-rna based guide rna expression
|
US11542466B2
(en)
|
2015-12-22 |
2023-01-03 |
North Carolina State University |
Methods and compositions for delivery of CRISPR based antimicrobials
|
KR20180099768A
(ko)
|
2015-12-30 |
2018-09-05 |
노파르티스 아게 |
증진된 효능을 갖는 면역 이펙터 세포 요법
|
KR20180095719A
(ko)
|
2016-01-11 |
2018-08-27 |
더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 |
키메라 단백질 및 면역요법 방법
|
CA3009194A1
(en)
|
2016-01-11 |
2017-07-20 |
The Board Of Trustees Of The Leland Stanford Junior University |
Chimeric proteins and methods of regulating gene expression
|
WO2017124037A1
(en)
|
2016-01-15 |
2017-07-20 |
The Children's Medical Center Corporation |
Therapeutic use of mitochondria and combined mitochondrial agents
|
US11136589B2
(en)
|
2016-01-26 |
2021-10-05 |
Pioneer Hi-Bred International, Inc. |
Waxy corn
|
US10876129B2
(en)
|
2016-02-12 |
2020-12-29 |
Ceres, Inc. |
Methods and materials for high throughput testing of mutagenized allele combinations
|
EP3881857A1
(en)
|
2016-02-18 |
2021-09-22 |
The Penn State Research Foundation |
Generating gabaergic neurons in brains
|
US20190249172A1
(en)
|
2016-02-18 |
2019-08-15 |
The Regents Of The University Of California |
Methods and compositions for gene editing in stem cells
|
US20190144942A1
(en)
|
2016-02-22 |
2019-05-16 |
Massachusetts Institute Of Technology |
Methods for identifying and modulating immune phenotypes
|
US10538750B2
(en)
|
2016-02-29 |
2020-01-21 |
Agilent Technologies, Inc. |
Methods and compositions for blocking off-target nucleic acids from cleavage by CRISPR proteins
|
CA3016571A1
(en)
|
2016-03-04 |
2017-09-08 |
Indoor Biotechnologies Inc. |
Fel d 1 knockouts and associated compositions and methods based on crispr-cas9 genomic editing
|
WO2017155714A1
(en)
|
2016-03-11 |
2017-09-14 |
Pioneer Hi-Bred International, Inc. |
Novel cas9 systems and methods of use
|
WO2017155717A1
(en)
|
2016-03-11 |
2017-09-14 |
Pioneer Hi-Bred International, Inc. |
Novel cas9 systems and methods of use
|
WO2017155715A1
(en)
|
2016-03-11 |
2017-09-14 |
Pioneer Hi-Bred International, Inc. |
Novel cas9 systems and methods of use
|
CN109414414A
(zh)
|
2016-03-16 |
2019-03-01 |
戴维·格拉德斯通研究所 |
用于治疗肥胖症和/或糖尿病以及用于鉴定候选治疗剂的方法和组合物
|
WO2017161325A1
(en)
|
2016-03-17 |
2017-09-21 |
Massachusetts Institute Of Technology |
Methods for identifying and modulating co-occurant cellular phenotypes
|
EP3219799A1
(en)
|
2016-03-17 |
2017-09-20 |
IMBA-Institut für Molekulare Biotechnologie GmbH |
Conditional crispr sgrna expression
|
EP3433362B1
(en)
|
2016-03-23 |
2021-05-05 |
Dana-Farber Cancer Institute, Inc. |
Methods for enhancing the efficiency of gene editing
|
US11512311B2
(en)
|
2016-03-25 |
2022-11-29 |
Editas Medicine, Inc. |
Systems and methods for treating alpha 1-antitrypsin (A1AT) deficiency
|
EP3433363A1
(en)
|
2016-03-25 |
2019-01-30 |
Editas Medicine, Inc. |
Genome editing systems comprising repair-modulating enzyme molecules and methods of their use
|
EP4047092A1
(en)
|
2016-04-13 |
2022-08-24 |
Editas Medicine, Inc. |
Cas9 fusion molecules, gene editing systems, and methods of use thereof
|
SG11201809041TA
(en)
|
2016-04-15 |
2018-11-29 |
Novartis Ag |
Compositions and methods for selective protein expression
|
CA3026112A1
(en)
|
2016-04-19 |
2017-10-26 |
The Broad Institute, Inc. |
Cpf1 complexes with reduced indel activity
|
CN105861485B
(zh)
*
|
2016-04-20 |
2021-08-17 |
上海伊丽萨生物科技有限公司 |
一种提高基因置换效率的方法
|
KR102440880B1
(ko)
*
|
2016-04-20 |
2022-09-06 |
센트로 데 인베스띠가씨오네스 에너제티까스 메디오암비엔딸레스 와이 테크놀로지까스, 오.에이., 엠.피. |
Pklr의 유전자 발현 증강을 위한 조성물 및 방법
|
EP3449016A4
(en)
|
2016-04-25 |
2019-10-02 |
President and Fellows of Harvard College |
HYBRIDIZATION CHAIN REACTION PROCESS FOR IN-SITU MOLECULE DETECTION
|
US20190203207A1
(en)
*
|
2016-05-20 |
2019-07-04 |
The Trustees Of Columbia University In The City Of New York |
Anabolic Enhancers for Ameliorating Neurodegeneration
|
CA3025171A1
(en)
|
2016-05-24 |
2017-11-30 |
Indiana University Research And Technology Corporation |
Ku inhibitors and their use for gene editing
|
GB201609811D0
(en)
|
2016-06-05 |
2016-07-20 |
Snipr Technologies Ltd |
Methods, cells, systems, arrays, RNA and kits
|
US10767175B2
(en)
|
2016-06-08 |
2020-09-08 |
Agilent Technologies, Inc. |
High specificity genome editing using chemically modified guide RNAs
|
EP3455357A1
(en)
|
2016-06-17 |
2019-03-20 |
The Broad Institute Inc. |
Type vi crispr orthologs and systems
|
EP3471544B1
(en)
|
2016-06-21 |
2021-12-22 |
The Curators Of The University Of Missouri |
Modified dystrophin proteins
|
US10017760B2
(en)
|
2016-06-24 |
2018-07-10 |
Inscripta, Inc. |
Methods for generating barcoded combinatorial libraries
|
MX2019000088A
(es)
|
2016-06-27 |
2019-08-29 |
Broad Inst Inc |
Composiciones y metodos para detectar y tratar la diabetes.
|
KR102345899B1
(ko)
|
2016-06-30 |
2021-12-31 |
지머젠 인코포레이티드 |
박테리아 헤모글로빈 라이브러리를 생성하는 방법 및 이의 용도
|
KR102345898B1
(ko)
|
2016-06-30 |
2022-01-03 |
지머젠 인코포레이티드 |
글루코오스 투과 효소 라이브러리를 생성하는 방법 및 이의 용도
|
EP3478852B1
(en)
|
2016-07-01 |
2020-08-12 |
Microsoft Technology Licensing, LLC |
Storage through iterative dna editing
|
US20180004537A1
(en)
|
2016-07-01 |
2018-01-04 |
Microsoft Technology Licensing, Llc |
Molecular State Machines
|
US11359234B2
(en)
|
2016-07-01 |
2022-06-14 |
Microsoft Technology Licensing, Llc |
Barcoding sequences for identification of gene expression
|
CN109863143B
(zh)
|
2016-07-13 |
2021-10-15 |
威泰克斯制药公司 |
提高基因组编辑效率的方法、组合物和试剂盒
|
AU2017295886C1
(en)
|
2016-07-15 |
2024-05-16 |
Novartis Ag |
Treatment and prevention of cytokine release syndrome using a chimeric antigen receptor in combination with a kinase inhibitor
|
EP3487523B1
(en)
|
2016-07-19 |
2023-09-06 |
Duke University |
Therapeutic applications of cpf1-based genome editing
|
CA3032822A1
(en)
|
2016-08-02 |
2018-02-08 |
Editas Medicine, Inc. |
Compositions and methods for treating cep290 associated disease
|
EP3494215A1
(en)
|
2016-08-03 |
2019-06-12 |
President and Fellows of Harvard College |
Adenosine nucleobase editors and uses thereof
|
US11078481B1
(en)
|
2016-08-03 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for screening for cancer targets
|
EP3497214B1
(en)
|
2016-08-09 |
2023-06-28 |
President and Fellows of Harvard College |
Programmable cas9-recombinase fusion proteins and uses thereof
|
US12012598B2
(en)
*
|
2016-08-12 |
2024-06-18 |
Toolgen Incorporated |
Manipulated immunoregulatory element and immunity altered thereby
|
WO2018030874A1
(ko)
*
|
2016-08-12 |
2018-02-15 |
주식회사 툴젠 |
조작된 면역조절요소 및 이에 의해 변형된 면역 활성
|
WO2018035388A1
(en)
|
2016-08-17 |
2018-02-22 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
US11630103B2
(en)
|
2016-08-17 |
2023-04-18 |
The Broad Institute, Inc. |
Product and methods useful for modulating and evaluating immune responses
|
EP3500967A1
(en)
|
2016-08-17 |
2019-06-26 |
The Broad Institute, Inc. |
Methods for identifying class 2 crispr-cas systems
|
WO2020225754A1
(en)
|
2019-05-06 |
2020-11-12 |
Mcmullen Tara |
Crispr gene editing for autosomal dominant diseases
|
KR20230155013A
(ko)
|
2016-08-20 |
2023-11-09 |
아벨리노 랩 유에스에이, 인크. |
단일 가이드 RNA, CRISPR/Cas9 시스템, 및 이의 사용방법
|
WO2018039438A1
(en)
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
US11078483B1
(en)
|
2016-09-02 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for measuring and improving CRISPR reagent function
|
WO2018049025A2
(en)
|
2016-09-07 |
2018-03-15 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses
|
JP7256739B2
(ja)
|
2016-09-07 |
2023-04-12 |
サンガモ セラピューティクス, インコーポレイテッド |
肝臓遺伝子のモジュレーション
|
IL247752A0
(en)
|
2016-09-11 |
2016-11-30 |
Yeda Res & Dev |
Compositions and methods for modulating gene expression for site-directed mutagenesis
|
US20190225974A1
(en)
|
2016-09-23 |
2019-07-25 |
BASF Agricultural Solutions Seed US LLC |
Targeted genome optimization in plants
|
EP3519577A1
(en)
|
2016-09-28 |
2019-08-07 |
Novartis AG |
Porous membrane-based macromolecule delivery system
|
GB2569733B
(en)
|
2016-09-30 |
2022-09-14 |
Univ California |
RNA-guided nucleic acid modifying enzymes and methods of use thereof
|
WO2018067546A1
(en)
|
2016-10-03 |
2018-04-12 |
President And Fellows Of Harvard College |
Delivery of therapeutic rnas via arrdc1-mediated microvesicles
|
US10669539B2
(en)
|
2016-10-06 |
2020-06-02 |
Pioneer Biolabs, Llc |
Methods and compositions for generating CRISPR guide RNA libraries
|
WO2018067991A1
(en)
|
2016-10-07 |
2018-04-12 |
The Brigham And Women's Hospital, Inc. |
Modulation of novel immune checkpoint targets
|
CN109844121A
(zh)
|
2016-10-13 |
2019-06-04 |
先锋国际良种公司 |
产生北方叶枯病抗性玉蜀黍
|
US11306324B2
(en)
|
2016-10-14 |
2022-04-19 |
President And Fellows Of Harvard College |
AAV delivery of nucleobase editors
|
GB201617559D0
(en)
|
2016-10-17 |
2016-11-30 |
University Court Of The University Of Edinburgh The |
Swine comprising modified cd163 and associated methods
|
US10738338B2
(en)
|
2016-10-18 |
2020-08-11 |
The Research Foundation for the State University |
Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate
|
CN110520530A
(zh)
|
2016-10-18 |
2019-11-29 |
明尼苏达大学董事会 |
肿瘤浸润性淋巴细胞和治疗方法
|
WO2018081531A2
(en)
|
2016-10-28 |
2018-05-03 |
Ariad Pharmaceuticals, Inc. |
Methods for human t-cell activation
|
EP3532615A1
(en)
*
|
2016-10-28 |
2019-09-04 |
Genethon |
Compositions and methods for the treatment of myotonic dystrophy
|
WO2018076335A1
(en)
|
2016-10-31 |
2018-05-03 |
Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences |
Compositions and methods for enhancing abiotic stress tolerance
|
WO2018083606A1
(en)
|
2016-11-01 |
2018-05-11 |
Novartis Ag |
Methods and compositions for enhancing gene editing
|
US20190264218A1
(en)
|
2016-11-04 |
2019-08-29 |
Flagship Pioneering Innovations V, Inc. |
Novel Plant Cells, Plants, and Seeds
|
US12227578B2
(en)
|
2016-11-11 |
2025-02-18 |
The Broad Institute, Inc. |
Modulation of intestinal epithelial cell differentiation, maintenance and/or function through T cell action
|
US20180135080A1
(en)
|
2016-11-15 |
2018-05-17 |
Genomic Vision Sa |
Method for the monitoring of modified nucleases induced-gene editing events by molecular combing
|
CN110199031A
(zh)
|
2016-11-29 |
2019-09-03 |
基因组影像公司 |
设计用于分析感兴趣的遗传区域中的特定事件的一组多核苷酸序列的方法
|
US9816093B1
(en)
|
2016-12-06 |
2017-11-14 |
Caribou Biosciences, Inc. |
Engineered nucleic acid-targeting nucleic acids
|
US11129906B1
(en)
|
2016-12-07 |
2021-09-28 |
David Gordon Bermudes |
Chimeric protein toxins for expression by therapeutic bacteria
|
US11180535B1
(en)
|
2016-12-07 |
2021-11-23 |
David Gordon Bermudes |
Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
|
RU2019121992A
(ru)
|
2016-12-14 |
2021-01-15 |
Лигандал, Инк. |
Способы и композиции для доставки полезной нагрузки в виде нуклеиновых кислот и белков
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
WO2018129129A1
(en)
|
2017-01-05 |
2018-07-12 |
Rutgers, The State University Of New Jersey |
Targeted gene editing platform independent of dna double strand break and uses thereof
|
WO2018127585A1
(en)
|
2017-01-06 |
2018-07-12 |
Txcell |
Monospecific regulatory t cell population with cytotoxicity for b cells
|
WO2018129368A2
(en)
|
2017-01-06 |
2018-07-12 |
Editas Medicine, Inc. |
Methods of assessing nuclease cleavage
|
EP3346001A1
(en)
|
2017-01-06 |
2018-07-11 |
TXCell |
Monospecific regulatory t cell population with cytotoxicity for b cells
|
WO2018129440A1
(en)
|
2017-01-09 |
2018-07-12 |
University Of Massachusetts |
Complexes for gene deletion and editing
|
KR102698684B1
(ko)
|
2017-01-12 |
2024-08-27 |
피벗 바이오, 인크. |
식물 형질 개선을 위한 방법 및 조성물
|
WO2018140725A1
(en)
|
2017-01-26 |
2018-08-02 |
Novartis Ag |
Cd28 compositions and methods for chimeric antigen receptor therapy
|
CA3051585A1
(en)
|
2017-01-28 |
2018-08-02 |
Inari Agriculture, Inc. |
Novel plant cells, plants, and seeds
|
EP3577134A1
(en)
|
2017-01-31 |
2019-12-11 |
Novartis AG |
Treatment of cancer using chimeric t cell receptor proteins having multiple specificities
|
TW201839136A
(zh)
|
2017-02-06 |
2018-11-01 |
瑞士商諾華公司 |
治療血色素異常症之組合物及方法
|
KR20190116282A
(ko)
|
2017-02-10 |
2019-10-14 |
지머젠 인코포레이티드 |
복수의 숙주를 위한 다중 dna 구조체의 조립 및 편집을 위한 모듈식 범용 플라스미드 디자인 전략
|
US10828330B2
(en)
|
2017-02-22 |
2020-11-10 |
IO Bioscience, Inc. |
Nucleic acid constructs comprising gene editing multi-sites and uses thereof
|
US20190381192A1
(en)
*
|
2017-02-22 |
2019-12-19 |
Io Biosciences, Inc. |
Nucleic acid constructs comprising gene editing multi-sites and uses thereof
|
WO2018160731A1
(en)
|
2017-02-28 |
2018-09-07 |
Novartis Ag |
Shp inhibitor compositions and uses for chimeric antigen receptor therapy
|
US11898179B2
(en)
|
2017-03-09 |
2024-02-13 |
President And Fellows Of Harvard College |
Suppression of pain by gene editing
|
KR20190127797A
(ko)
|
2017-03-10 |
2019-11-13 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
시토신에서 구아닌으로의 염기 편집제
|
WO2018170184A1
(en)
|
2017-03-14 |
2018-09-20 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
WO2018170333A1
(en)
|
2017-03-15 |
2018-09-20 |
The Broad Institute, Inc. |
Novel cas13b orthologues crispr enzymes and systems
|
WO2018170436A1
(en)
|
2017-03-16 |
2018-09-20 |
Jacobs Farm Del Cabo |
Basil with high tolerance to downy mildew
|
US12180546B2
(en)
|
2017-03-17 |
2024-12-31 |
Massachusetts Institute Of Technology |
Methods for identifying and modulating co-occurant cellular phenotypes
|
CA3057192A1
(en)
|
2017-03-23 |
2018-09-27 |
President And Fellows Of Harvard College |
Nucleobase editors comprising nucleic acid programmable dna binding proteins
|
WO2018175924A1
(en)
|
2017-03-24 |
2018-09-27 |
The Broad Institute, Inc. |
Methods and compositions for regulating innate lymphoid cell inflammatory responses
|
WO2018183878A1
(en)
|
2017-03-31 |
2018-10-04 |
Pioneer Hi-Bred International, Inc. |
Expression modulating elements and use thereof
|
WO2018183908A1
(en)
|
2017-03-31 |
2018-10-04 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for treating ovarian tumors
|
US11913075B2
(en)
|
2017-04-01 |
2024-02-27 |
The Broad Institute, Inc. |
Methods and compositions for detecting and modulating an immunotherapy resistance gene signature in cancer
|
WO2018191520A1
(en)
|
2017-04-12 |
2018-10-18 |
The Broad Institute, Inc. |
Respiratory and sweat gland ionocytes
|
AU2018251801B2
(en)
|
2017-04-12 |
2024-11-07 |
Massachusetts Institute Of Technology |
Novel type VI CRISPR orthologs and systems
|
EP3610266A4
(en)
|
2017-04-12 |
2021-04-21 |
Massachusetts Eye and Ear Infirmary |
TUMOR SIGNATURE FOR METASTASIS, COMPOSITIONS OF MATERIAL AND THEIR METHODS OF USE
|
US20200405639A1
(en)
|
2017-04-14 |
2020-12-31 |
The Broad Institute, Inc. |
Novel delivery of large payloads
|
US20210293783A1
(en)
|
2017-04-18 |
2021-09-23 |
The General Hospital Corporation |
Compositions for detecting secretion and methods of use
|
US11834670B2
(en)
|
2017-04-19 |
2023-12-05 |
Global Life Sciences Solutions Usa Llc |
Site-specific DNA modification using a donor DNA repair template having tandem repeat sequences
|
SG11201909797QA
(en)
|
2017-04-20 |
2019-11-28 |
Egenesis Inc |
Methods for generating genetically modified animals
|
EP3612232A1
(en)
|
2017-04-21 |
2020-02-26 |
The Broad Institute, Inc. |
Targeted delivery to beta cells
|
CA3059956A1
(en)
|
2017-04-21 |
2018-10-25 |
The General Hospital Corporation |
Variants of cpf1 (cas12a) with altered pam specificity
|
EP3615672A1
(en)
|
2017-04-28 |
2020-03-04 |
Editas Medicine, Inc. |
Methods and systems for analyzing guide rna molecules
|
EP3615068A1
(en)
|
2017-04-28 |
2020-03-04 |
Novartis AG |
Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor
|
US20200055948A1
(en)
|
2017-04-28 |
2020-02-20 |
Novartis Ag |
Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor
|
US11591601B2
(en)
|
2017-05-05 |
2023-02-28 |
The Broad Institute, Inc. |
Methods for identification and modification of lncRNA associated with target genotypes and phenotypes
|
EP3622070A2
(en)
|
2017-05-10 |
2020-03-18 |
Editas Medicine, Inc. |
Crispr/rna-guided nuclease systems and methods
|
WO2018209324A2
(en)
|
2017-05-11 |
2018-11-15 |
The Broad Institute, Inc. |
Methods and compositions of use of cd8+ tumor infiltrating lymphocyte subtypes and gene signatures thereof
|
WO2018209320A1
(en)
|
2017-05-12 |
2018-11-15 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation
|
JP7364472B2
(ja)
|
2017-05-18 |
2023-10-18 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
標的化された核酸編集のための系、方法、及び組成物
|
AU2018272067B2
(en)
|
2017-05-25 |
2024-07-18 |
The General Hospital Corporation |
Base editors with improved precision and specificity
|
EP3409104A1
(en)
|
2017-05-31 |
2018-12-05 |
Vilmorin et Cie |
Tomato plant resistant to tomato yellow leaf curl virus, powdery mildew, and nematodes
|
WO2020249996A1
(en)
|
2019-06-14 |
2020-12-17 |
Vilmorin & Cie |
Resistance in plants of solanum lycopersicum to the tobamovirus tomato brown rugose fruit virus
|
EP3409106A1
(en)
|
2017-06-01 |
2018-12-05 |
Vilmorin et Cie |
Tolerance in plants of solanum lycopersicum to the tobamovirus tomato brown rugose fruit virus (tbrfv)
|
AU2018280116A1
(en)
|
2017-06-05 |
2020-01-02 |
Research Institute At Nationwide Children's Hospital |
Enhanced modified viral capsid proteins
|
CA3102054A1
(en)
|
2017-06-05 |
2018-12-13 |
Fred Hutchinson Cancer Research Center |
Genomic safe harbors for genetic therapies in human stem cells and engineered nanoparticles to provide targeted genetic therapies
|
CN110945125A
(zh)
|
2017-06-06 |
2020-03-31 |
齐默尔根公司 |
用于改进大肠杆菌的htp基因工程改造平台
|
JP7227162B2
(ja)
|
2017-06-06 |
2023-02-21 |
ザイマージェン インコーポレイテッド |
真菌株を改良するためのhtpゲノム操作プラットフォーム
|
FI3636753T3
(fi)
*
|
2017-06-08 |
2024-05-03 |
Univ Osaka |
Menetelmä DNA-muokatun eukaryoottisen solun valmistamiseksi
|
US11845942B2
(en)
|
2017-06-09 |
2023-12-19 |
Vilmorin & Cie |
Compositions and methods for genome editing
|
AU2018279829B2
(en)
|
2017-06-09 |
2024-01-04 |
Editas Medicine, Inc. |
Engineered Cas9 nucleases
|
BR112019026226A2
(pt)
|
2017-06-13 |
2020-06-30 |
Flagship Pioneering Innovations V, Inc. |
composições compreendendo curóns e usos dos mesmos
|
US11897953B2
(en)
|
2017-06-14 |
2024-02-13 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
CN118599915A
(zh)
|
2017-06-15 |
2024-09-06 |
加利福尼亚大学董事会 |
靶向非病毒dna插入
|
US9982279B1
(en)
|
2017-06-23 |
2018-05-29 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
US10011849B1
(en)
|
2017-06-23 |
2018-07-03 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
US20210093667A1
(en)
|
2017-06-26 |
2021-04-01 |
The Broad Institute, Inc. |
Crispr/cas-adenine deaminase based compositions, systems, and methods for targeted nucleic acid editing
|
EP3645021A4
(en)
|
2017-06-30 |
2021-04-21 |
Intima Bioscience, Inc. |
ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY
|
US11168322B2
(en)
|
2017-06-30 |
2021-11-09 |
Arbor Biotechnologies, Inc. |
CRISPR RNA targeting enzymes and systems and uses thereof
|
WO2019003193A1
(en)
|
2017-06-30 |
2019-01-03 |
Novartis Ag |
METHODS FOR TREATING DISEASES USING GENE EDITING SYSTEMS
|
WO2019014581A1
(en)
|
2017-07-14 |
2019-01-17 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR MODULATING THE ACTIVITY OF A CYTOTOXIC LYMPHOCYTE
|
EP3652312A1
(en)
|
2017-07-14 |
2020-05-20 |
Editas Medicine, Inc. |
Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites
|
US12105089B2
(en)
|
2017-07-17 |
2024-10-01 |
The Broad Institute, Inc. |
Cell atlas of the healthy and ulcerative colitis human colon
|
US10510743B2
(en)
*
|
2017-07-18 |
2019-12-17 |
Hong Kong Applied Science and Technology Research Institute Company, Limited |
Step fin field-effect-transistor (FinFET) with slim top of fin and thick bottom of fin for electro-static-discharge (ESD) or electrical over-stress (EOS) protection
|
AU2018303164B2
(en)
*
|
2017-07-18 |
2024-09-19 |
Genovie Ab |
A two-component vector library system for rapid assembly and diversification of full-length T-cell receptor open reading frames
|
WO2019023291A2
(en)
|
2017-07-25 |
2019-01-31 |
Dana-Farber Cancer Institute, Inc. |
COMPOSITIONS AND METHODS FOR PRODUCTION AND DECODING OF GUIDE RNA LIBRARIES AND USES THEREOF
|
CN111801345A
(zh)
|
2017-07-28 |
2020-10-20 |
哈佛大学的校长及成员们 |
使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物
|
EP3625356B1
(en)
|
2017-08-08 |
2021-05-19 |
Depixus |
In vitro isolation and enrichment of nucleic acids using site-specific nucleases
|
US11970720B2
(en)
|
2017-08-22 |
2024-04-30 |
Salk Institute For Biological Studies |
RNA targeting methods and compositions
|
US10476825B2
(en)
|
2017-08-22 |
2019-11-12 |
Salk Institue for Biological Studies |
RNA targeting methods and compositions
|
WO2019040650A1
(en)
|
2017-08-23 |
2019-02-28 |
The General Hospital Corporation |
GENETICALLY MODIFIED CRISPR-CAS9 NUCLEASES HAVING MODIFIED PAM SPECIFICITY
|
CN118374452A
(zh)
*
|
2017-08-25 |
2024-07-23 |
隆萨销售股份公司 |
使用膜蛋白制备治疗性外来体
|
EP3676376B1
(en)
|
2017-08-30 |
2025-01-15 |
President and Fellows of Harvard College |
High efficiency base editors comprising gam
|
AR113064A1
(es)
|
2017-09-15 |
2020-01-22 |
Covercress Inc |
Composición que comprende harina de carraspique con bajo contenido de fibras y métodos para su elaboración
|
JP7281774B2
(ja)
|
2017-09-19 |
2023-05-26 |
ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア |
抗hla-a2抗体及びその使用方法
|
JP7317023B2
(ja)
|
2017-09-20 |
2023-07-28 |
ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア |
新規抗hla-a2抗体、およびその使用
|
CN109517820B
(zh)
|
2017-09-20 |
2021-09-24 |
北京宇繁生物科技有限公司 |
一种靶向HPK1的gRNA以及HPK1基因编辑方法
|
US11534471B2
(en)
|
2017-09-21 |
2022-12-27 |
Dana-Farber Cancer Institute, Inc. |
Isolation, preservation, compositions and uses of extracts from justicia plants
|
US11252928B2
(en)
|
2017-09-21 |
2022-02-22 |
The Condard-Pyle Company |
Miniature rose plant named ‘Meibenbino’
|
WO2019060746A1
(en)
|
2017-09-21 |
2019-03-28 |
The Broad Institute, Inc. |
SYSTEMS, METHODS, AND COMPOSITIONS FOR THE TARGETED EDITING OF NUCLEIC ACIDS
|
US11917978B2
(en)
|
2017-09-21 |
2024-03-05 |
The Conard Pyle Company |
Miniature rose plant named ‘meibenbino’
|
US12043870B2
(en)
|
2017-10-02 |
2024-07-23 |
The Broad Institute, Inc. |
Methods and compositions for detecting and modulating an immunotherapy resistance gene signature in cancer
|
EP3692152A4
(en)
|
2017-10-04 |
2021-12-01 |
The Broad Institute, Inc. |
PROCESSES AND COMPOSITIONS FOR MODIFYING THE FUNCTION AND STRUCTURE OF CHROMATIN LOOPS AND / OR DOMAINS
|
WO2019075197A1
(en)
|
2017-10-11 |
2019-04-18 |
The General Hospital Corporation |
METHODS OF DETECTION OF INDIVIDUAL SITE-SPECIFIC PARASITE GENOMIC DEAMINATION BY BASE EDITING TECHNOLOGIES
|
WO2019079362A1
(en)
|
2017-10-16 |
2019-04-25 |
Massachusetts Institute Of Technology |
HOST-PATHOGENIC INTERACTION OF MYCOBACTERIUM TUBERCULOSIS
|
US11642422B2
(en)
|
2017-10-16 |
2023-05-09 |
Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, O.A, M.P. |
Lentiviral vectors for delivery of PKLR to treat pyruvate kinase deficiency
|
CA3082251A1
(en)
|
2017-10-16 |
2019-04-25 |
The Broad Institute, Inc. |
Uses of adenosine base editors
|
EP3697895A4
(en)
|
2017-10-20 |
2021-12-08 |
Fred Hutchinson Cancer Research Center |
SYSTEMS AND METHODS FOR PRODUCING GENETICALLY MODIFIED B LYMPHOCYTES TO EXPRESS SELECTED ANTIBODIES
|
US12227742B2
(en)
|
2017-10-23 |
2025-02-18 |
The Broad Institute, Inc. |
Nucleic acid modifiers
|
MX2020004343A
(es)
|
2017-10-25 |
2021-01-08 |
Pivot Bio Inc |
Métodos y composiciones para mejorar microbios modificados que fijan nitrógeno.
|
EP3700879A4
(en)
|
2017-10-25 |
2022-01-12 |
Pivot Bio, Inc. |
GEN TARGETS FOR NITROGEN FIXATION TARGETING TO IMPROVE PLANT CHARACTERISTICS
|
SG11202003798TA
(en)
|
2017-10-27 |
2020-05-28 |
Univ California |
Targeted replacement of endogenous t cell receptors
|
WO2019089803A1
(en)
|
2017-10-31 |
2019-05-09 |
The Broad Institute, Inc. |
Methods and compositions for studying cell evolution
|
US20210179709A1
(en)
|
2017-10-31 |
2021-06-17 |
Novartis Ag |
Anti-car compositions and methods
|
WO2019087113A1
(en)
|
2017-11-01 |
2019-05-09 |
Novartis Ag |
Synthetic rnas and methods of use
|
WO2019089804A1
(en)
|
2017-11-01 |
2019-05-09 |
The Regents Of The University Of California |
Casy compositions and methods of use
|
KR20200091858A
(ko)
|
2017-11-01 |
2020-07-31 |
더 리젠츠 오브 더 유니버시티 오브 캘리포니아 |
CasZ 조성물 및 사용 방법
|
WO2019090173A1
(en)
|
2017-11-02 |
2019-05-09 |
Arbor Biotechnologies, Inc. |
Novel crispr-associated transposon systems and components
|
US12171783B2
(en)
|
2017-11-13 |
2024-12-24 |
The Broad Institute, Inc. |
Methods and compositions for targeting developmental and oncogenic programs in H3K27M gliomas
|
WO2019094983A1
(en)
|
2017-11-13 |
2019-05-16 |
The Broad Institute, Inc. |
Methods and compositions for treating cancer by targeting the clec2d-klrb1 pathway
|
WO2019094984A1
(en)
|
2017-11-13 |
2019-05-16 |
The Broad Institute, Inc. |
Methods for determining spatial and temporal gene expression dynamics during adult neurogenesis in single cells
|
DK3710576T3
(da)
|
2017-11-17 |
2025-01-02 |
Iovance Biotherapeutics Inc |
Til-ekspansion fra finnålsaspirater og små biopsier
|
JP2021503885A
(ja)
|
2017-11-22 |
2021-02-15 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
末梢血からの末梢血リンパ球(pbl)の拡大培養
|
BR112020010326A2
(pt)
*
|
2017-12-05 |
2020-10-20 |
Synthetic Genomics, Inc. |
aperfeiçoamento da produtividade lipídica de algas através da modificação genética de uma proteína de sinalização
|
WO2019113506A1
(en)
|
2017-12-07 |
2019-06-13 |
The Broad Institute, Inc. |
Methods and compositions for multiplexing single cell and single nuclei sequencing
|
BR112020011350A2
(pt)
|
2017-12-08 |
2020-11-17 |
Synthetic Genomics, Inc. |
aperfeiçoamento da produtividade lipídica de algas através da modificação genética de uma proteína que contém domínio de tpr
|
WO2019118463A1
(en)
|
2017-12-15 |
2019-06-20 |
Danisco Us Inc |
Cas9 variants and methods of use
|
JP2021506814A
(ja)
|
2017-12-15 |
2021-02-22 |
デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド |
安定化ペプチドによって介在される標的タンパク質の分解
|
JP7507090B2
(ja)
|
2017-12-28 |
2024-06-27 |
ロンザ セールス アーゲー |
免疫腫瘍及び抗炎症療法のためのエクソソーム
|
WO2019133881A1
(en)
|
2017-12-29 |
2019-07-04 |
Rubius Therapeutics, Inc. |
Gene editing and targeted transcriptional modulation for enginerering erythroid cells
|
US11994512B2
(en)
|
2018-01-04 |
2024-05-28 |
Massachusetts Institute Of Technology |
Single-cell genomic methods to generate ex vivo cell systems that recapitulate in vivo biology with improved fidelity
|
CA3086620A1
(en)
|
2018-01-12 |
2019-07-18 |
Basf Se |
Gene underlying the number of spikelets per spike qtl in wheat on chromosome 7a
|
MA51623A
(fr)
|
2018-01-17 |
2021-04-14 |
Vertex Pharma |
Composés de quinoxalinone, compositions, procédés et kits pour augmenter l'efficacité d'édition du génome
|
US12005127B2
(en)
|
2018-01-17 |
2024-06-11 |
Vertex Pharmaceuticals Incorporated |
DNA-PK inhibitors
|
US12121524B2
(en)
|
2018-01-17 |
2024-10-22 |
Vertex Pharmaceuticals Incorporated |
DNA-PK inhibitors
|
US20210084936A1
(en)
|
2018-01-19 |
2021-03-25 |
Covercress Inc. |
Low glucosinolate pennycress meal and methods of making
|
US20190233816A1
(en)
|
2018-01-26 |
2019-08-01 |
Massachusetts Institute Of Technology |
Structure-guided chemical modification of guide rna and its applications
|
US11926835B1
(en)
|
2018-01-29 |
2024-03-12 |
Inari Agriculture Technology, Inc. |
Methods for efficient tomato genome editing
|
KR102136132B1
(ko)
*
|
2018-01-31 |
2020-07-22 |
서울대학교 산학협력단 |
CRISPR/Cas9 시스템을 통한 닭 백혈병 바이러스(Avian Leukosis Virus, ALV) 저항성 조류의 제조방법
|
CA3087715A1
(en)
|
2018-02-08 |
2019-08-15 |
Zymergen Inc. |
Genome editing using crispr in corynebacterium
|
CN111902536B
(zh)
*
|
2018-02-15 |
2024-07-30 |
西格马-奥尔德里奇有限责任公司 |
用于真核基因组修饰的改造的cas9系统
|
CN112020554B
(zh)
|
2018-02-23 |
2024-10-22 |
先锋国际良种公司 |
新颖cas9直系同源物
|
US11390876B2
(en)
|
2018-03-09 |
2022-07-19 |
Pioneer Hi-Bred International, Inc. |
Compositions and methods for modification of fatty acids in soybean
|
JP2021518102A
(ja)
|
2018-03-14 |
2021-08-02 |
エディタス・メディシン、インコーポレイテッド |
異常ヘモグロビン症の治療のためのシステム及び方法
|
CA3093334A1
(en)
|
2018-03-14 |
2019-09-19 |
Arbor Biotechnologies, Inc. |
Novel crispr dna targeting enzymes and systems
|
ES2953541T3
(es)
|
2018-03-14 |
2023-11-14 |
Arbor Biotechnologies Inc |
Sistemas y enzimas novedosos de direccionamiento a ADN y ARN de CRISPR
|
US10760075B2
(en)
|
2018-04-30 |
2020-09-01 |
Snipr Biome Aps |
Treating and preventing microbial infections
|
WO2019195738A1
(en)
|
2018-04-06 |
2019-10-10 |
Children's Medical Center Corporation |
Compositions and methods for somatic cell reprogramming and modulating imprinting
|
US11981739B2
(en)
|
2018-04-13 |
2024-05-14 |
Sangamo Therapeutics France |
Chimeric antigen receptor specific for interleukin-23 receptor
|
JP7460539B2
(ja)
|
2018-04-17 |
2024-04-02 |
ザ ジェネラル ホスピタル コーポレイション |
核酸を結合、修飾、および切断する物質の基質選択性および部位のためのin vitroでの高感度アッセイ
|
WO2019204585A1
(en)
|
2018-04-19 |
2019-10-24 |
Massachusetts Institute Of Technology |
Single-stranded break detection in double-stranded dna
|
WO2019204766A1
(en)
|
2018-04-19 |
2019-10-24 |
The Regents Of The University Of California |
Compositions and methods for gene editing
|
PL3560330T3
(pl)
|
2018-04-24 |
2022-09-19 |
KWS SAAT SE & Co. KGaA |
Rośliny o ulepszonej strawności i haplotypach markerowych
|
US11957695B2
(en)
|
2018-04-26 |
2024-04-16 |
The Broad Institute, Inc. |
Methods and compositions targeting glucocorticoid signaling for modulating immune responses
|
SG11202010319RA
(en)
|
2018-04-27 |
2020-11-27 |
Iovance Biotherapeutics Inc |
Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy
|
US20210147831A1
(en)
|
2018-04-27 |
2021-05-20 |
The Broad Institute, Inc. |
Sequencing-based proteomics
|
CA3098127A1
(en)
|
2018-04-27 |
2019-10-31 |
Genedit Inc. |
Cationic polymer and use for biomolecule delivery
|
US20210047405A1
(en)
|
2018-04-27 |
2021-02-18 |
Novartis Ag |
Car t cell therapies with enhanced efficacy
|
WO2019213660A2
(en)
|
2018-05-04 |
2019-11-07 |
The Broad Institute, Inc. |
Compositions and methods for modulating cgrp signaling to regulate innate lymphoid cell inflammatory responses
|
WO2019222545A1
(en)
|
2018-05-16 |
2019-11-21 |
Synthego Corporation |
Methods and systems for guide rna design and use
|
WO2019222555A1
(en)
|
2018-05-16 |
2019-11-21 |
Arbor Biotechnologies, Inc. |
Novel crispr-associated systems and components
|
EP3797160A1
(en)
|
2018-05-23 |
2021-03-31 |
The Broad Institute Inc. |
Base editors and uses thereof
|
CN112204156A
(zh)
|
2018-05-25 |
2021-01-08 |
先锋国际良种公司 |
用于通过调节重组率来改善育种的系统和方法
|
CN108707628B
(zh)
*
|
2018-05-28 |
2021-11-23 |
上海海洋大学 |
斑马鱼notch2基因突变体的制备方法
|
WO2019232542A2
(en)
|
2018-06-01 |
2019-12-05 |
Massachusetts Institute Of Technology |
Methods and compositions for detecting and modulating microenvironment gene signatures from the csf of metastasis patients
|
US11866719B1
(en)
|
2018-06-04 |
2024-01-09 |
Inari Agriculture Technology, Inc. |
Heterologous integration of regulatory elements to alter gene expression in wheat cells and wheat plants
|
EP3578658A1
(en)
*
|
2018-06-08 |
2019-12-11 |
Johann Wolfgang Goethe-Universität Frankfurt |
Method for generating a gene editing vector with fixed guide rna pairs
|
US20220403001A1
(en)
|
2018-06-12 |
2022-12-22 |
Obsidian Therapeutics, Inc. |
Pde5 derived regulatory constructs and methods of use in immunotherapy
|
EP3806962A1
(en)
|
2018-06-13 |
2021-04-21 |
Novartis AG |
Bcma chimeric antigen receptors and uses thereof
|
US12036240B2
(en)
|
2018-06-14 |
2024-07-16 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
CA3102264A1
(en)
*
|
2018-06-19 |
2019-12-26 |
Lunella Biotech, Inc. |
"energetic" cancer stem cells (e-cscs): a new hyper-metabolic and proliferative tumor cell phenotype, driven by mitochondrial energy
|
KR20210040943A
(ko)
|
2018-06-26 |
2021-04-14 |
매사추세츠 인스티튜트 오브 테크놀로지 |
Crispr 이펙터 시스템 기반 증폭 방법, 시스템, 및 진단
|
CN112368396A
(zh)
|
2018-06-26 |
2021-02-12 |
博德研究所 |
基于crispr/cas和转座酶的扩增组合物、系统和方法
|
US11963530B2
(en)
|
2018-06-27 |
2024-04-23 |
Pivot Bio, Inc. |
Agricultural compositions comprising remodeled nitrogen fixing microbes
|
EP3814369A1
(en)
|
2018-06-29 |
2021-05-05 |
Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis |
Tweak-receptor agonists for use in combination with immunotherapy of a cancer
|
CN112513270B
(zh)
|
2018-07-13 |
2025-02-25 |
加利福尼亚大学董事会 |
基于逆转录转座子的递送媒介物及其使用方法
|
WO2020018142A1
(en)
|
2018-07-16 |
2020-01-23 |
Arbor Biotechnologies, Inc. |
Novel crispr dna targeting enzymes and systems
|
WO2020028555A2
(en)
|
2018-07-31 |
2020-02-06 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
WO2020028729A1
(en)
|
2018-08-01 |
2020-02-06 |
Mammoth Biosciences, Inc. |
Programmable nuclease compositions and methods of use thereof
|
CA3106035A1
(en)
|
2018-08-07 |
2020-02-13 |
The Broad Institute, Inc. |
Cas12b enzymes and systems
|
CA3109253A1
(en)
|
2018-08-10 |
2020-02-13 |
Sangamo Therapeutics France |
New car constructs comprising tnfr2 domains
|
EP3607819A1
(en)
|
2018-08-10 |
2020-02-12 |
Vilmorin et Cie |
Resistance to xanthomonas campestris pv. campestris (xcc) in cauliflower
|
CN112703250A
(zh)
|
2018-08-15 |
2021-04-23 |
齐默尔根公司 |
CRISPRi在高通量代谢工程中的应用
|
US20210317429A1
(en)
|
2018-08-20 |
2021-10-14 |
The Broad Institute, Inc. |
Methods and compositions for optochemical control of crispr-cas9
|
US20210324357A1
(en)
|
2018-08-20 |
2021-10-21 |
The Brigham And Women's Hospital, Inc. |
Degradation domain modifications for spatio-temporal control of rna-guided nucleases
|
CA3109592A1
(en)
|
2018-08-23 |
2020-02-27 |
Sangamo Therapeutics, Inc. |
Engineered target specific base editors
|
US11479762B1
(en)
|
2018-08-31 |
2022-10-25 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
WO2020051507A1
(en)
|
2018-09-06 |
2020-03-12 |
The Broad Institute, Inc. |
Nucleic acid assemblies for use in targeted delivery
|
EP3849565A4
(en)
|
2018-09-12 |
2022-12-28 |
Fred Hutchinson Cancer Research Center |
REDUCTION OF CD33 EXPRESSION TO SELECTIVELY PROTECT THERAPEUTIC CELLS
|
EP3852813A4
(en)
|
2018-09-18 |
2022-06-22 |
VNV Newco Inc. |
ARC-BASED CAPSIDS AND THEIR USES
|
CN109265562B
(zh)
*
|
2018-09-26 |
2021-03-30 |
北京市农林科学院 |
一种切刻酶及其在基因组碱基替换中的应用
|
GB201815820D0
(en)
|
2018-09-28 |
2018-11-14 |
Univ Wageningen |
Off-target activity inhibitors for guided endonucleases
|
WO2020072253A1
(en)
|
2018-10-01 |
2020-04-09 |
North Carolina State University |
Recombinant type i crispr-cas system and uses thereof for screening for variant cells
|
WO2020072248A1
(en)
|
2018-10-01 |
2020-04-09 |
North Carolina State University |
Recombinant type i crispr-cas system
|
WO2020076976A1
(en)
|
2018-10-10 |
2020-04-16 |
Readcoor, Inc. |
Three-dimensional spatial molecular indexing
|
US20220411783A1
(en)
|
2018-10-12 |
2022-12-29 |
The Broad Institute, Inc. |
Method for extracting nuclei or whole cells from formalin-fixed paraffin-embedded tissues
|
US11851663B2
(en)
|
2018-10-14 |
2023-12-26 |
Snipr Biome Aps |
Single-vector type I vectors
|
WO2020081730A2
(en)
|
2018-10-16 |
2020-04-23 |
Massachusetts Institute Of Technology |
Methods and compositions for modulating microenvironment
|
WO2020086910A1
(en)
|
2018-10-24 |
2020-04-30 |
Genedit Inc. |
Cationic polymer with alkyl side chains and use for biomolecule delivery
|
EP3870600A1
(en)
|
2018-10-24 |
2021-09-01 |
Obsidian Therapeutics, Inc. |
Er tunable protein regulation
|
US11407995B1
(en)
|
2018-10-26 |
2022-08-09 |
Inari Agriculture Technology, Inc. |
RNA-guided nucleases and DNA binding proteins
|
SG11202104347UA
(en)
*
|
2018-10-29 |
2021-05-28 |
Univ China Agricultural |
Novel crispr/cas12f enzyme and system
|
SG11202104409YA
(en)
|
2018-10-31 |
2021-05-28 |
Zymergen Inc |
Multiplexed deterministic assembly of dna libraries
|
US20210395760A1
(en)
|
2018-10-31 |
2021-12-23 |
Pioneer Hi-Bred International, Inc. |
Compositions and methods for ochrobactrum-mediated gene editing
|
US11970733B2
(en)
|
2018-11-01 |
2024-04-30 |
Synthego Corporation |
Methods for analyzing nucleic acid sequences
|
US11434477B1
(en)
|
2018-11-02 |
2022-09-06 |
Inari Agriculture Technology, Inc. |
RNA-guided nucleases and DNA binding proteins
|
EP3877511A1
(en)
|
2018-11-05 |
2021-09-15 |
Iovance Biotherapeutics, Inc. |
Expansion of tils utilizing akt pathway inhibitors
|
CN113272420A
(zh)
|
2018-11-05 |
2021-08-17 |
艾欧凡斯生物治疗公司 |
经改进的肿瘤反应性t细胞的选择
|
AU2019377422A1
(en)
|
2018-11-05 |
2021-05-27 |
Iovance Biotherapeutics, Inc. |
Treatment of NSCLC patients refractory for anti-PD-1 antibody
|
US20220090018A1
(en)
|
2018-11-05 |
2022-03-24 |
Iovance Biotherapeutics, Inc. |
Processes for production of tumor infiltrating lymphocytes and used of the same in immunotherapy
|
US12165743B2
(en)
|
2018-11-09 |
2024-12-10 |
The Broad Institute, Inc. |
Compressed sensing for screening and tissue imaging
|
US20220282275A1
(en)
|
2018-11-15 |
2022-09-08 |
The Broad Institute, Inc. |
G-to-t base editors and uses thereof
|
US11166996B2
(en)
|
2018-12-12 |
2021-11-09 |
Flagship Pioneering Innovations V, Inc. |
Anellovirus compositions and methods of use
|
BR112021011372A2
(pt)
|
2018-12-14 |
2021-08-31 |
Pioneer Hi-Bred International, Inc. |
Novos sistemas crispr-cas para edição de genoma
|
WO2020131862A1
(en)
|
2018-12-17 |
2020-06-25 |
The Broad Institute, Inc. |
Crispr-associated transposase systems and methods of use thereof
|
WO2020131586A2
(en)
|
2018-12-17 |
2020-06-25 |
The Broad Institute, Inc. |
Methods for identifying neoantigens
|
BR112021011629A2
(pt)
|
2018-12-18 |
2021-09-08 |
Braskem S.A. |
Via de coprodução de derivados de 3-hp e acetil-coa a partir de malonato semialdeído
|
EP3898949A1
(en)
|
2018-12-19 |
2021-10-27 |
Iovance Biotherapeutics, Inc. |
Methods of expanding tumor infiltrating lymphocytes using engineered cytokine receptor pairs and uses thereof
|
AU2019401485A1
(en)
|
2018-12-21 |
2021-06-24 |
Pivot Bio, Inc. |
Methods, compositions, and media for improving plant traits
|
US20200208160A1
(en)
|
2018-12-28 |
2020-07-02 |
Braskem S.A. |
Modulation of carbon flux through the meg and c3 pathways for the improved production of monoethylene glycol and c3 compounds
|
CN113574386A
(zh)
|
2019-01-03 |
2021-10-29 |
国家医疗保健研究所 |
用于增强癌症患者的cd8+t细胞依赖性免疫应答的方法和药物组合物
|
WO2020142754A2
(en)
|
2019-01-04 |
2020-07-09 |
Mammoth Biosciences, Inc. |
Programmable nuclease improvements and compositions and methods for nucleic acid amplification and detection
|
US11739156B2
(en)
|
2019-01-06 |
2023-08-29 |
The Broad Institute, Inc. Massachusetts Institute of Technology |
Methods and compositions for overcoming immunosuppression
|
US20220106584A1
(en)
|
2019-01-14 |
2022-04-07 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and kits for generating and selecting a variant of a binding protein with increased binding affinity and/or specificity
|
WO2020163396A1
(en)
|
2019-02-04 |
2020-08-13 |
The General Hospital Corporation |
Adenine dna base editor variants with reduced off-target rna editing
|
JP2022519308A
(ja)
|
2019-02-06 |
2022-03-22 |
フレッド ハッチンソン キャンサー リサーチ センター |
その中の核酸分子を差次的にメチル化するように操作されたミニサークル産生細菌
|
US20220145330A1
(en)
|
2019-02-10 |
2022-05-12 |
The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glads |
Modified mitochondrion and methods of use thereof
|
CN110177061B
(zh)
*
|
2019-03-01 |
2023-04-07 |
致讯科技(天津)有限公司 |
一种异构网络中信号干扰的协调方法
|
EP3921435A1
(en)
|
2019-03-01 |
2021-12-15 |
Braskem S.A. |
Method for the in vivo synthesis of 4-hydroxymethylfurfural and derivatives thereof
|
EP3931310A1
(en)
|
2019-03-01 |
2022-01-05 |
Iovance Biotherapeutics, Inc. |
Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof
|
US20220170013A1
(en)
|
2019-03-06 |
2022-06-02 |
The Broad Institute, Inc. |
T:a to a:t base editing through adenosine methylation
|
WO2020181195A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
T:a to a:t base editing through adenine excision
|
WO2020181178A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
T:a to a:t base editing through thymine alkylation
|
WO2020181180A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
A:t to c:g base editors and uses thereof
|
WO2020181202A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
A:t to t:a base editing through adenine deamination and oxidation
|
EP4219700A1
(en)
|
2019-03-07 |
2023-08-02 |
The Regents of the University of California |
Crispr-cas effector polypeptides and methods of use thereof
|
CN113728106A
(zh)
|
2019-03-08 |
2021-11-30 |
齐默尔根公司 |
微生物中的迭代基因组编辑
|
US11053515B2
(en)
|
2019-03-08 |
2021-07-06 |
Zymergen Inc. |
Pooled genome editing in microbes
|
KR20210149251A
(ko)
|
2019-03-08 |
2021-12-08 |
옵시디안 테라퓨틱스, 인크. |
조율가능한 조절을 위한 인간 탄산 무수화효소 2 조성물 및 방법
|
CA3127814C
(en)
|
2019-03-18 |
2024-05-14 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas dropout screening platform to reveal genetic vulnerabilities associated with tau aggregation
|
IL312893A
(en)
|
2019-03-18 |
2024-07-01 |
Regeneron Pharma |
Crispr/cas screening platform to identify genetic modifiers of tau seeding or aggregation
|
DE112020001342T5
(de)
|
2019-03-19 |
2022-01-13 |
President and Fellows of Harvard College |
Verfahren und Zusammensetzungen zum Editing von Nukleotidsequenzen
|
WO2020206036A1
(en)
|
2019-04-01 |
2020-10-08 |
The Broad Institute, Inc. |
Novel nucleic acid modifier
|
RU2710731C1
(ru)
*
|
2019-04-02 |
2020-01-10 |
Общество с ограниченной ответственностью "Зеленые линии" |
Система редактирования генома дрожжей debaryomyces hansenii на основе crispr/cas9
|
CN114008197A
(zh)
|
2019-04-04 |
2022-02-01 |
布拉斯科公司 |
用于同时消耗木糖和葡萄糖以从第二代糖产生化学物质的代谢工程
|
WO2020214842A1
(en)
|
2019-04-17 |
2020-10-22 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
MX2021012908A
(es)
|
2019-04-23 |
2022-01-31 |
Genedit Inc |
Polimero cationico con cadenas laterales de alquilo.
|
CA3137739A1
(en)
|
2019-04-24 |
2020-10-29 |
Pivot Bio, Inc. |
Gene targets for nitrogen fixation targeting for improving plant traits
|
EP3959320A1
(en)
|
2019-04-24 |
2022-03-02 |
Novartis AG |
Compositions and methods for selective protein degradation
|
AU2020274594A1
(en)
|
2019-05-10 |
2022-01-20 |
Basf Se |
Regulatory nucleic acid molecules for enhancing gene expression in plants
|
EP3969607A1
(en)
|
2019-05-13 |
2022-03-23 |
KWS SAAT SE & Co. KGaA |
Drought tolerance in corn
|
WO2020232029A1
(en)
|
2019-05-13 |
2020-11-19 |
Iovance Biotherapeutics, Inc. |
Methods and compositions for selecting tumor infiltrating lymphocytes and uses of the same in immunotherapy
|
WO2020236972A2
(en)
|
2019-05-20 |
2020-11-26 |
The Broad Institute, Inc. |
Non-class i multi-component nucleic acid targeting systems
|
WO2020236967A1
(en)
|
2019-05-20 |
2020-11-26 |
The Broad Institute, Inc. |
Random crispr-cas deletion mutant
|
WO2020236982A1
(en)
|
2019-05-20 |
2020-11-26 |
The Broad Institute, Inc. |
Aav delivery of nucleobase editors
|
AR118995A1
(es)
|
2019-05-25 |
2021-11-17 |
Kws Saat Se & Co Kgaa |
Mejorador de la inducción de haploides
|
US20220340712A1
(en)
|
2019-05-28 |
2022-10-27 |
GenEdit, Inc. |
Polymer comprising multiple functionalized sidechains for biomolecule delivery
|
WO2020243661A1
(en)
|
2019-05-31 |
2020-12-03 |
The Broad Institute, Inc. |
Methods for treating metabolic disorders by targeting adcy5
|
JP2022534437A
(ja)
*
|
2019-06-01 |
2022-07-29 |
シベック バイオテクノロジーズ,リミティド ライアビリティ カンパニー |
真核細胞への遺伝子編集システムの送達のための細菌プラットフォーム
|
WO2020244759A1
(en)
|
2019-06-05 |
2020-12-10 |
Klemm & Sohn Gmbh & Co. Kg |
New plants having a white foliage phenotype
|
KR20220024053A
(ko)
|
2019-06-14 |
2022-03-03 |
리제너론 파마슈티칼스 인코포레이티드 |
타우병증의 모델
|
WO2020254850A1
(en)
|
2019-06-21 |
2020-12-24 |
Vilmorin & Cie |
Improvement of quality and permanence of green color of peppers at maturity and over-maturity
|
AU2020308448A1
(en)
|
2019-06-24 |
2022-02-03 |
Promega Corporation |
Modified polyamine polymers for delivery of biomolecules into cells
|
EP3990633A1
(en)
|
2019-06-25 |
2022-05-04 |
Inari Agriculture Technology, Inc. |
Improved homology dependent repair genome editing
|
AU2020298572A1
(en)
|
2019-07-02 |
2021-11-18 |
Fred Hutchinson Cancer Center |
Recombinant Ad35 vectors and related gene therapy improvements
|
GB201909597D0
(en)
|
2019-07-03 |
2019-08-14 |
Univ Wageningen |
Crispr type v-u1 system from mycobacterium mucogenicum and uses thereof
|
BR112021026890A2
(pt)
|
2019-07-08 |
2022-03-15 |
Res Inst Nationwide Childrens Hospital |
Composições de anticorpo para interromper biofilmes
|
CN110387405A
(zh)
*
|
2019-07-17 |
2019-10-29 |
浙江善测禾骑士生物科技有限公司 |
一种快速检测核酸的(rt)raa-crispr系统
|
CN110452966A
(zh)
*
|
2019-07-17 |
2019-11-15 |
浙江善测禾骑士生物科技有限公司 |
一种利用raa-crispr蛋白酶系统快速检测方法
|
WO2021009299A1
(en)
|
2019-07-17 |
2021-01-21 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Bcl-xl:fkbp12 fusion proteins suitable for screening agents capable of slowing down the aging process
|
WO2021019272A1
(en)
|
2019-07-31 |
2021-02-04 |
Vilmorin & Cie |
Tolerance to tolcndv in cucumber
|
EP3772542A1
(en)
|
2019-08-07 |
2021-02-10 |
KWS SAAT SE & Co. KGaA |
Modifying genetic variation in crops by modulating the pachytene checkpoint protein 2
|
WO2021028359A1
(en)
|
2019-08-09 |
2021-02-18 |
Sangamo Therapeutics France |
Controlled expression of chimeric antigen receptors in t cells
|
US20220282284A1
(en)
*
|
2019-08-15 |
2022-09-08 |
The Rockefeller University |
Crispr genome editing with cell surface display to produce homozygously edited eukaryotic cells
|
WO2021030666A1
(en)
|
2019-08-15 |
2021-02-18 |
The Broad Institute, Inc. |
Base editing by transglycosylation
|
US20220298501A1
(en)
|
2019-08-30 |
2022-09-22 |
The Broad Institute, Inc. |
Crispr-associated mu transposase systems
|
WO2021046451A1
(en)
|
2019-09-06 |
2021-03-11 |
Obsidian Therapeutics, Inc. |
Compositions and methods for dhfr tunable protein regulation
|
AU2020344905A1
(en)
|
2019-09-12 |
2022-04-28 |
Basf Se |
Regulatory nucleic acid molecules for enhancing gene expression in plants
|
CN115175996A
(zh)
|
2019-09-20 |
2022-10-11 |
博德研究所 |
新颖vi型crispr酶和系统
|
CN110541001A
(zh)
*
|
2019-09-20 |
2019-12-06 |
福建上源生物科学技术有限公司 |
精确大片段基因删除结合终止密码子插入的基因敲除法
|
US11987791B2
(en)
|
2019-09-23 |
2024-05-21 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating hepatocyte nuclear factor 4-alpha (HNF4α) gene expression
|
CN114391040A
(zh)
|
2019-09-23 |
2022-04-22 |
欧米茄治疗公司 |
用于调节载脂蛋白b(apob)基因表达的组合物和方法
|
US11981922B2
(en)
|
2019-10-03 |
2024-05-14 |
Dana-Farber Cancer Institute, Inc. |
Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment
|
WO2021069387A1
(en)
|
2019-10-07 |
2021-04-15 |
Basf Se |
Regulatory nucleic acid molecules for enhancing gene expression in plants
|
EP3808766A1
(en)
|
2019-10-15 |
2021-04-21 |
Sangamo Therapeutics France |
Chimeric antigen receptor specific for interleukin-23 receptor
|
US20230357788A1
(en)
|
2019-10-17 |
2023-11-09 |
KWS SAAT SE & Co. KGaA |
Enhanced disease resistance of crops by downregulation of repressor genes
|
JP2022553389A
(ja)
|
2019-10-25 |
2022-12-22 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
腫瘍浸潤リンパ球の遺伝子編集及び免疫療法におけるその使用
|
EP4057802A1
(en)
|
2019-11-14 |
2022-09-21 |
Vilmorin & Cie |
Resistance to acidovorax valerianellae in corn salad
|
KR20220104766A
(ko)
|
2019-11-22 |
2022-07-26 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
약물 전달을 위한 이온성 액체
|
WO2021108717A2
(en)
|
2019-11-26 |
2021-06-03 |
The Broad Institute, Inc |
Systems and methods for evaluating cas9-independent off-target editing of nucleic acids
|
CN114945273A
(zh)
|
2019-11-29 |
2022-08-26 |
巴斯夫欧洲公司 |
增加植物对抗真菌感染的抗性
|
AU2020394910A1
(en)
*
|
2019-12-02 |
2022-06-23 |
Council Of Scientific & Industrial Research |
Method and kit for detection of polynucleotide
|
CA3159805A1
(en)
|
2019-12-03 |
2021-06-10 |
Frank Meulewaeter |
Regulatory nucleic acid molecules for enhancing gene expression in plants
|
US20230220341A1
(en)
|
2019-12-11 |
2023-07-13 |
lovance Biotherapeutics, Inc. |
Processes for the production of tumor infiltrating lymphocytes (tils) and methods of using the same
|
JPWO2021117874A1
(da)
|
2019-12-13 |
2021-06-17 |
|
|
KR20220116504A
(ko)
|
2019-12-19 |
2022-08-23 |
바스프 에스이 |
정밀 화학물의 제조에서 공시 수율, 탄소-전환-효율 및 탄소 기질 적응성의 증가
|
WO2021122528A1
(en)
|
2019-12-20 |
2021-06-24 |
Basf Se |
Decreasing toxicity of terpenes and increasing the production potential in micro-organisms
|
JP2023510872A
(ja)
|
2020-01-13 |
2023-03-15 |
サナ バイオテクノロジー,インコーポレイテッド |
血液型抗原の修飾
|
WO2021221690A1
(en)
|
2020-05-01 |
2021-11-04 |
Pivot Bio, Inc. |
Modified bacterial strains for improved fixation of nitrogen
|
EP4093857A4
(en)
|
2020-01-23 |
2024-02-21 |
The Children's Medical Center Corporation |
DIFFERENTIATION OF STROMA-FREE T CELLS FROM HUMAN PLURIPOTENT STEM CELLS
|
EP4100519A2
(en)
|
2020-02-05 |
2022-12-14 |
The Broad Institute, Inc. |
Adenine base editors and uses thereof
|
US12116580B2
(en)
|
2020-02-21 |
2024-10-15 |
The Board Of Trustees Of The University Of Illinois |
Genetic toolbox for metabolic engineering of non-conventional yeast
|
EP3872190A1
(en)
|
2020-02-26 |
2021-09-01 |
Antibodies-Online GmbH |
A method of using cut&run or cut&tag to validate crispr-cas targeting
|
CA3173528A1
(en)
|
2020-03-11 |
2021-09-16 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating forkhead box p3 (foxp3) gene expression
|
CN115916823A
(zh)
|
2020-03-20 |
2023-04-04 |
法国国家健康和医学研究院 |
人cd45rc特异的嵌合抗原受体及其用途
|
US12057197B2
(en)
|
2020-04-03 |
2024-08-06 |
Creyon Bio, Inc. |
Oligonucleotide-based machine learning
|
WO2021216622A1
(en)
|
2020-04-21 |
2021-10-28 |
Aspen Neuroscience, Inc. |
Gene editing of gba1 in stem cells and method of use of cells differentiated therefrom
|
US20230165909A1
(en)
|
2020-04-21 |
2023-06-01 |
Aspen Neuroscience, Inc. |
Gene editing of lrrk2 in stem cells and method of use of cells differentiated therefrom
|
EP4138805A1
(en)
|
2020-04-23 |
2023-03-01 |
Genedit Inc. |
Polymer with cationic and hydrophobic side chains
|
WO2021221689A1
(en)
|
2020-05-01 |
2021-11-04 |
Pivot Bio, Inc. |
Measurement of nitrogen fixation and incorporation
|
CA3172322A1
(en)
|
2020-05-01 |
2021-11-04 |
Karsten TEMME |
Modified bacterial strains for improved fixation of nitrogen
|
WO2021226061A1
(en)
|
2020-05-04 |
2021-11-11 |
Iovance Biotherapeutics, Inc. |
Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy
|
US20230193212A1
(en)
|
2020-05-06 |
2023-06-22 |
Orchard Therapeutics (Europe) Limited |
Treatment for neurodegenerative diseases
|
WO2021226558A1
(en)
|
2020-05-08 |
2021-11-11 |
The Broad Institute, Inc. |
Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence
|
WO2021231449A2
(en)
|
2020-05-13 |
2021-11-18 |
Pivot Bio, Inc. |
De-repression of nitrogen fixation in gram-positive microorganisms
|
GB202007943D0
(en)
|
2020-05-27 |
2020-07-08 |
Snipr Biome Aps |
Products & methods
|
US20230279418A1
(en)
|
2020-05-29 |
2023-09-07 |
KWS SAAT SE & Co. KGaA |
Plant haploid induction
|
WO2021245435A1
(en)
|
2020-06-03 |
2021-12-09 |
Vilmorin & Cie |
Melon plants resistant to scab disease, aphids and powdery mildew
|
WO2021248052A1
(en)
|
2020-06-05 |
2021-12-09 |
The Broad Institute, Inc. |
Compositions and methods for treating neoplasia
|
CN115867129B
(zh)
|
2020-06-05 |
2025-01-10 |
维尔莫林公司 |
番茄植物对ToBRFV的抗性
|
AU2021288224A1
(en)
|
2020-06-11 |
2023-01-05 |
Novartis Ag |
ZBTB32 inhibitors and uses thereof
|
EP4179079A1
(en)
|
2020-07-10 |
2023-05-17 |
Horizon Discovery Limited |
Method for producing genetically modified cells
|
CA3184489A1
(en)
|
2020-07-14 |
2022-01-20 |
Abeona Therapeutics Inc. |
Recombinant adeno-associated viral vectors for multipartite gene delivery
|
US20230323299A1
(en)
|
2020-08-03 |
2023-10-12 |
Inserm (Institut National De La Santé Et De La Recherch Médicale) |
Population of treg cells functionally committed to exert a regulatory activity and their use for adoptive therapy
|
CN116096378A
(zh)
|
2020-08-10 |
2023-05-09 |
诺华股份有限公司 |
视网膜变性疾病的治疗
|
US20220049303A1
(en)
|
2020-08-17 |
2022-02-17 |
Readcoor, Llc |
Methods and systems for spatial mapping of genetic variants
|
MX2023001762A
(es)
|
2020-08-18 |
2023-02-22 |
Pioneer Hi Bred Int |
Genes de resistencia a multiples enfermedades y apilamientos genomicos de los mismos.
|
LT4058474T
(lt)
|
2020-08-20 |
2024-08-26 |
A2 Biotherapeutics, Inc. |
Kompozicijos ir būdai, skirti gydyti egfr atžvilgiu teigiamas vėžio formas
|
JP7634653B2
(ja)
|
2020-08-20 |
2025-02-21 |
エー2 バイオセラピューティクス, インコーポレイテッド |
メソテリン陽性がんを治療するための組成物及び方法
|
KR20230052291A
(ko)
|
2020-08-20 |
2023-04-19 |
에이투 바이오쎄라퓨틱스, 인크. |
Ceacam 양성 암을 치료하기 위한 조성물 및 방법
|
CN112080587A
(zh)
*
|
2020-08-31 |
2020-12-15 |
上海海关动植物与食品检验检疫技术中心 |
用于高效检测新型冠状病毒的raa-crispr扩增引物组、试剂盒及方法
|
KR102424351B1
(ko)
*
|
2020-09-21 |
2022-08-05 |
한국과학기술원 |
파브알부민 유전자 발현 억제용 CRISPR/Cas9 시스템 및 이의 용도
|
WO2022188039A1
(en)
|
2021-03-09 |
2022-09-15 |
Huigene Therapeutics Co., Ltd. |
Engineered crispr/cas13 system and uses thereof
|
WO2022068912A1
(en)
|
2020-09-30 |
2022-04-07 |
Huigene Therapeutics Co., Ltd. |
Engineered crispr/cas13 system and uses thereof
|
US11944063B2
(en)
|
2020-09-30 |
2024-04-02 |
Spring Meadow Nursery, Inc. |
Hydrangea ‘SMNHPH’
|
MA60153A1
(fr)
|
2020-10-02 |
2023-08-31 |
Vilmorin & Cie |
Melon à durée de conservation prolongée
|
EP4225330A1
(en)
|
2020-10-06 |
2023-08-16 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
WO2022076606A1
(en)
|
2020-10-06 |
2022-04-14 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
EP4321015A3
(en)
|
2020-10-16 |
2024-04-17 |
Klemm & Sohn GmbH & Co. KG |
Double-flowering dwarf calibrachoa
|
US11155884B1
(en)
|
2020-10-16 |
2021-10-26 |
Klemm & Sohn Gmbh & Co. Kg |
Double-flowering dwarf Calibrachoa
|
US11530419B2
(en)
|
2020-10-30 |
2022-12-20 |
Fortiphyte, Inc. |
Pathogen resistance in plants
|
IL302700A
(en)
|
2020-11-13 |
2023-07-01 |
Novartis Ag |
Combination therapies with chimeric antigen receptor (car)-expressing cells
|
EP4001429A1
(en)
|
2020-11-16 |
2022-05-25 |
Antibodies-Online GmbH |
Analysis of crispr-cas binding and cleavage sites followed by high-throughput sequencing (abc-seq)
|
WO2022117884A1
(en)
|
2020-12-03 |
2022-06-09 |
Vilmorin & Cie |
Tomato plants resistant to tobrfv, tmv, tomv and tommv and corresponding resistance genes
|
US20240123067A1
(en)
|
2020-12-17 |
2024-04-18 |
Iovance Biotherapeutics, Inc. |
Treatment of cancers with tumor infiltrating lymphocyte therapies
|
AU2021401302A1
(en)
|
2020-12-17 |
2023-07-06 |
Iovance Biotherapeutics, Inc. |
Treatment with tumor infiltrating lymphocyte therapies in combination with ctla-4 and pd-1 inhibitors
|
MX2023007643A
(es)
|
2020-12-23 |
2023-09-04 |
Flagship Pioneering Innovations V Inc |
Ensamblaje in vitro de cápsides de anellovirus que encierran arn.
|
WO2022148955A1
(en)
|
2021-01-05 |
2022-07-14 |
Horizon Discovery Limited |
Method for producing genetically modified cells
|
WO2022150776A1
(en)
*
|
2021-01-11 |
2022-07-14 |
Vedere Bio Ii, Inc. |
OPTOGENETIC COMPOSITIONS COMPRISING A CBh PROMOTER SEQUENCE AND METHODS FOR USE
|
AU2022207981A1
(en)
|
2021-01-12 |
2023-07-27 |
March Therapeutics, Inc. |
Context-dependent, double-stranded dna-specific deaminases and uses thereof
|
TW202241508A
(zh)
|
2021-01-29 |
2022-11-01 |
美商艾歐凡斯生物治療公司 |
細胞介素相關之腫瘤浸潤性淋巴球組合物及方法
|
EP4288541A1
(en)
|
2021-02-05 |
2023-12-13 |
Christiana Care Gene Editing Institute, Inc. |
Methods of and compositions for reducing gene expression and/or activity
|
JP2024507129A
(ja)
|
2021-02-16 |
2024-02-16 |
エー2 バイオセラピューティクス, インコーポレイテッド |
Her2陽性がんを治療するための組成物及び方法
|
EP4305157A1
(en)
|
2021-03-09 |
2024-01-17 |
Huidagene Therapeutics (Singapore) Pte. Ltd. |
Engineered crispr/cas13 system and uses thereof
|
US20240191191A1
(en)
|
2021-03-19 |
2024-06-13 |
Iovance Biotherapeutics, Inc. |
Methods for infiltrating lymphocyte (til) expansion related to cd39/cd69 selection and gene knockout in tils
|
EP4314016A1
(en)
|
2021-03-31 |
2024-02-07 |
Entrada Therapeutics, Inc. |
Cyclic cell penetrating peptides
|
WO2022208489A1
(en)
|
2021-04-02 |
2022-10-06 |
Vilmorin & Cie |
Semi-determinate or determinate growth habit trait in cucurbita
|
EP4323501A1
(en)
|
2021-04-16 |
2024-02-21 |
Beam Therapeutics Inc. |
Genetic modification of hepatocytes
|
EP4326287A2
(en)
|
2021-04-19 |
2024-02-28 |
Iovance Biotherapeutics, Inc. |
Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies
|
WO2022235929A1
(en)
|
2021-05-05 |
2022-11-10 |
Radius Pharmaceuticals, Inc. |
Animal model having homologous recombination of mouse pth1 receptor
|
MX2023013352A
(es)
|
2021-05-10 |
2024-01-31 |
Entrada Therapeutics Inc |
Composiciones y métodos para terapéuticos intracelulares.
|
JP2024518476A
(ja)
|
2021-05-10 |
2024-05-01 |
エントラーダ セラピューティクス,インコーポレイティド |
mRNAスプライシングを調節するための組成物及び方法
|
US20250051393A1
(en)
|
2021-05-10 |
2025-02-13 |
Entrada Therapeutics, Inc. |
Compositions and methods for modulating interferon regulatory factor-5 (irf-5) activity
|
EP4337770A1
(en)
|
2021-05-13 |
2024-03-20 |
The United States of America, as represented by the Secretary, Department of Health and Human Services |
Compositions and methods for treating sickle cell diseases
|
US20240269180A1
(en)
|
2021-05-17 |
2024-08-15 |
Iovance Biotherapeutics, Inc. |
Pd-1 gene-edited tumor infiltrating lymphocytes and uses of same in immunotherapy
|
US20230023791A1
(en)
|
2021-06-01 |
2023-01-26 |
Arbor Biotechnologies, Inc. |
Gene editing systems comprising a crispr nuclease and uses thereof
|
US20240285781A1
(en)
|
2021-06-11 |
2024-08-29 |
GenEdit, Inc. |
Biodegradable polymer comprising side chains with polyamine and polyalkylene oxide groups
|
US20240287487A1
(en)
|
2021-06-11 |
2024-08-29 |
The Broad Institute, Inc. |
Improved cytosine to guanine base editors
|
WO2022266105A1
(en)
*
|
2021-06-14 |
2022-12-22 |
The University Of Chicago |
Characterization and treatment of asthma
|
PE20242357A1
(es)
|
2021-06-23 |
2024-12-16 |
Entrada Therapeutics Inc |
Compuestos antisentido y metodos para dirigirse a repeticiones cug
|
MX2024000026A
(es)
|
2021-07-02 |
2024-02-20 |
Pivot Bio Inc |
Cepas bacterianas dise?adas por ingenieria genetica para fijacion de nitrogeno mejorada.
|
EP4367242A2
(en)
|
2021-07-07 |
2024-05-15 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating secreted frizzled receptor protein 1 (sfrp1) gene expression
|
US20240365776A1
(en)
|
2021-07-22 |
2024-11-07 |
Iovance Biotherapeutics, Inc |
Method for cryopreservation of solid tumor fragments
|
CA3226942A1
(en)
|
2021-07-28 |
2023-02-02 |
Iovance Biotherapeutics, Inc. |
Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with kras inhibitors
|
EP4376596A1
(en)
|
2021-07-30 |
2024-06-05 |
KWS SAAT SE & Co. KGaA |
Plants with improved digestibility and marker haplotypes
|
CA3187918A1
(en)
|
2021-07-30 |
2023-01-30 |
Helaina, Inc. |
Methods and compositions for protein synthesis and secretion
|
EP4380353A1
(en)
|
2021-08-06 |
2024-06-12 |
Vilmorin & Cie |
Resistance to leveillula taurica in pepper
|
US20240368619A1
(en)
|
2021-09-02 |
2024-11-07 |
SESVanderHave NV |
Methods and compositions for ppo herbicide tolerance
|
WO2023039586A1
(en)
|
2021-09-10 |
2023-03-16 |
Agilent Technologies, Inc. |
Guide rnas with chemical modification for prime editing
|
WO2023056367A1
(en)
|
2021-09-30 |
2023-04-06 |
The Board Of Regents Of The Universityof Texas System |
Slc13a5 gene therapy vectors and uses thereof
|
CN118382429A
(zh)
|
2021-10-08 |
2024-07-23 |
哈佛大学校长及研究员协会 |
用于药物递送的离子液体
|
CR20240195A
(es)
|
2021-10-14 |
2024-06-20 |
Arsenal Biosciences Inc |
Células inmunitarias que tienen arnhc coexpresados y sistemas de compuerta lógica
|
JP2024541911A
(ja)
|
2021-10-27 |
2024-11-13 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
患者特異的免疫療法のための細胞の製造を調整するためのシステム及び方法
|
AU2022375820A1
(en)
|
2021-11-01 |
2024-06-13 |
Tome Biosciences, Inc. |
Single construct platform for simultaneous delivery of gene editing machinery and nucleic acid cargo
|
EP4426832A1
(en)
|
2021-11-03 |
2024-09-11 |
The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone |
Precise genome editing using retrons
|
AU2022381188A1
(en)
*
|
2021-11-03 |
2024-05-23 |
Salk Institute For Biological Studies |
Serine recombinases
|
US20250032618A1
(en)
|
2021-11-10 |
2025-01-30 |
Iovance Biotherapeutics, Inc. |
Methods of expansion treatment utilizing cd8 tumor infiltrating lymphocytes
|
WO2023092153A2
(en)
*
|
2021-11-22 |
2023-05-25 |
The Texas A&M University System |
Methods and compositions targeting nucleus accumbens-associated protein-1 for treatment of autoimmune disorders and cancers
|
EP4430199A2
(en)
|
2021-11-24 |
2024-09-18 |
Research Institute at Nationwide Children's Hospital |
Chimeric hsv expressing hil21 to boost anti-tumor immune activity
|
WO2023093862A1
(en)
|
2021-11-26 |
2023-06-01 |
Epigenic Therapeutics Inc. |
Method of modulating pcsk9 and uses thereof
|
WO2023102406A1
(en)
|
2021-12-01 |
2023-06-08 |
The Board Of Regents Of The Univesity Of Texas System |
Vector genome design to express optimized cln7 transgene
|
WO2023102518A1
(en)
|
2021-12-03 |
2023-06-08 |
The Board Of Regents Of The University Of Texas System |
Gnao1 gene therapy vectors and uses thereof
|
GB202118058D0
(en)
|
2021-12-14 |
2022-01-26 |
Univ Warwick |
Methods to increase yields in crops
|
US20230279442A1
(en)
|
2021-12-15 |
2023-09-07 |
Versitech Limited |
Engineered cas9-nucleases and method of use thereof
|
TW202342498A
(zh)
|
2021-12-17 |
2023-11-01 |
美商薩那生物科技公司 |
經修飾副黏液病毒科融合醣蛋白
|
US20240408192A1
(en)
|
2021-12-17 |
2024-12-12 |
Sana Biotechnology, Inc. |
Modified paramyxoviridae attachment glycoproteins
|
WO2023122805A1
(en)
|
2021-12-20 |
2023-06-29 |
Vestaron Corporation |
Sorbitol driven selection pressure method
|
IL313765A
(en)
|
2021-12-22 |
2024-08-01 |
Tome Biosciences Inc |
Joint provision of a gene editor structure and a donor template
|
IL313726A
(en)
|
2021-12-23 |
2024-08-01 |
Univ Massachusetts |
Medical treatment of fragile X-linked disorder
|
WO2023133595A2
(en)
|
2022-01-10 |
2023-07-13 |
Sana Biotechnology, Inc. |
Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
|
WO2023141602A2
(en)
|
2022-01-21 |
2023-07-27 |
Renagade Therapeutics Management Inc. |
Engineered retrons and methods of use
|
EP4469582A1
(en)
|
2022-01-28 |
2024-12-04 |
The Board Of Regents Of The University Of Texas System |
Transgene cassette designed to express the human codon-optimized gene
|
WO2023147488A1
(en)
|
2022-01-28 |
2023-08-03 |
Iovance Biotherapeutics, Inc. |
Cytokine associated tumor infiltrating lymphocytes compositions and methods
|
WO2023150518A1
(en)
|
2022-02-01 |
2023-08-10 |
Sana Biotechnology, Inc. |
Cd3-targeted lentiviral vectors and uses thereof
|
WO2023150647A1
(en)
|
2022-02-02 |
2023-08-10 |
Sana Biotechnology, Inc. |
Methods of repeat dosing and administration of lipid particles or viral vectors and related systems and uses
|
WO2023156587A1
(en)
|
2022-02-18 |
2023-08-24 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Use of tcr-deficient car-tregs in combination with anti-tcr complex monoclonal antibodies for inducing durable tolerance
|
AU2023248451A1
(en)
|
2022-04-04 |
2024-10-17 |
President And Fellows Of Harvard College |
Cas9 variants having non-canonical pam specificities and uses thereof
|
WO2023196877A1
(en)
|
2022-04-06 |
2023-10-12 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
EP4256950A1
(en)
|
2022-04-06 |
2023-10-11 |
Vilmorin et Cie |
Tolerance to cgmmv in cucumber
|
EP4507704A1
(en)
|
2022-04-15 |
2025-02-19 |
Iovance Biotherapeutics, Inc. |
Til expansion processes using specific cytokine combinations and/or akti treatment
|
WO2023205744A1
(en)
|
2022-04-20 |
2023-10-26 |
Tome Biosciences, Inc. |
Programmable gene insertion compositions
|
AU2023259642A1
(en)
|
2022-04-28 |
2024-11-14 |
President And Fellows Of Harvard College |
Aav vectors encoding base editors and uses thereof
|
WO2023215831A1
(en)
|
2022-05-04 |
2023-11-09 |
Tome Biosciences, Inc. |
Guide rna compositions for programmable gene insertion
|
WO2023220040A1
(en)
|
2022-05-09 |
2023-11-16 |
Synteny Therapeutics, Inc. |
Erythroparvovirus with a modified capsid for gene therapy
|
WO2023220035A1
(en)
|
2022-05-09 |
2023-11-16 |
Synteny Therapeutics, Inc. |
Erythroparvovirus compositions and methods for gene therapy
|
WO2023220043A1
(en)
|
2022-05-09 |
2023-11-16 |
Synteny Therapeutics, Inc. |
Erythroparvovirus with a modified genome for gene therapy
|
WO2023219933A1
(en)
|
2022-05-09 |
2023-11-16 |
Entrada Therapeutics, Inc. |
Compositions and methods for delivery of nucleic acid therapeutics
|
WO2023220608A1
(en)
|
2022-05-10 |
2023-11-16 |
Iovance Biotherapeutics, Inc. |
Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with an il-15r agonist
|
WO2023225670A2
(en)
|
2022-05-20 |
2023-11-23 |
Tome Biosciences, Inc. |
Ex vivo programmable gene insertion
|
KR20250019668A
(ko)
|
2022-05-25 |
2025-02-10 |
플래그쉽 파이어니어링 이노베이션스 Vii, 엘엘씨 |
순환 인자를 조절하기 위한 조성물 및 방법
|
KR20250019772A
(ko)
|
2022-05-25 |
2025-02-11 |
플래그쉽 파이어니어링 이노베이션스 Vii, 엘엘씨 |
종양 억제인자 및 발암유전자를 조절하기 위한 조성물 및 방법
|
AU2023277636A1
(en)
|
2022-05-25 |
2024-11-21 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and methods for modulating genetic drivers
|
KR20250017230A
(ko)
|
2022-05-25 |
2025-02-04 |
플래그쉽 파이어니어링 이노베이션스 Vii, 엘엘씨 |
사이토카인을 조절하기 위한 조성물 및 방법
|
AU2023276714A1
(en)
|
2022-05-25 |
2024-11-21 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and methods for modulation of immune responses
|
WO2023250511A2
(en)
|
2022-06-24 |
2023-12-28 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for reducing low-density lipoprotein through targeted gene repression
|
GB202209518D0
(en)
|
2022-06-29 |
2022-08-10 |
Snipr Biome Aps |
Treating & preventing E coli infections
|
GB2621813A
(en)
|
2022-06-30 |
2024-02-28 |
Univ Newcastle |
Preventing disease recurrence in Mitochondrial replacement therapy
|
WO2024006802A1
(en)
|
2022-06-30 |
2024-01-04 |
Pioneer Hi-Bred International, Inc. |
Artificial intelligence-mediated methods and systems for genome editing
|
EP4299733A1
(en)
|
2022-06-30 |
2024-01-03 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
WO2024005863A1
(en)
|
2022-06-30 |
2024-01-04 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
WO2024005864A1
(en)
|
2022-06-30 |
2024-01-04 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
EP4299739A1
(en)
|
2022-06-30 |
2024-01-03 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
WO2024020346A2
(en)
|
2022-07-18 |
2024-01-25 |
Renagade Therapeutics Management Inc. |
Gene editing components, systems, and methods of use
|
WO2024020587A2
(en)
|
2022-07-22 |
2024-01-25 |
Tome Biosciences, Inc. |
Pleiopluripotent stem cell programmable gene insertion
|
WO2024023578A1
(en)
|
2022-07-28 |
2024-02-01 |
Institut Pasteur |
Hsc70-4 in host-induced and spray-induced gene silencing
|
WO2024026406A2
(en)
|
2022-07-29 |
2024-02-01 |
Vestaron Corporation |
Next Generation ACTX Peptides
|
WO2024036190A2
(en)
|
2022-08-09 |
2024-02-15 |
Pioneer Hi-Bred International, Inc. |
Guide polynucleotide multiplexing
|
AU2023325079A1
(en)
|
2022-08-16 |
2025-02-13 |
President And Fellows Of Harvard College |
Evolved cytosine deaminases and methods of editing dna using same
|
WO2024040222A1
(en)
|
2022-08-19 |
2024-02-22 |
Generation Bio Co. |
Cleavable closed-ended dna (cedna) and methods of use thereof
|
WO2024044655A1
(en)
|
2022-08-24 |
2024-02-29 |
Sana Biotechnology, Inc. |
Delivery of heterologous proteins
|
WO2024044723A1
(en)
|
2022-08-25 |
2024-02-29 |
Renagade Therapeutics Management Inc. |
Engineered retrons and methods of use
|
AU2023329149A1
(en)
|
2022-08-26 |
2025-02-20 |
KWS SAAT SE & Co. KGaA |
Use of paired genes in hybrid breeding
|
WO2024050544A2
(en)
|
2022-09-01 |
2024-03-07 |
J.R. Simplot Company |
Enhanced targeted knock-in frequency in host genomes through crispr exonuclease processing
|
WO2024047605A1
(en)
|
2022-09-01 |
2024-03-07 |
SESVanderHave NV |
Methods and compositions for ppo herbicide tolerance
|
WO2024052318A1
(en)
|
2022-09-06 |
2024-03-14 |
Institut National de la Santé et de la Recherche Médicale |
Novel dual split car-t cells for the treatment of cd38-positive hematological malignancies
|
WO2024064838A1
(en)
|
2022-09-21 |
2024-03-28 |
Sana Biotechnology, Inc. |
Lipid particles comprising variant paramyxovirus attachment glycoproteins and uses thereof
|
WO2024064824A2
(en)
|
2022-09-21 |
2024-03-28 |
Yale University |
Compositions and methods for identification of membrane targets for enhancement of nk cell therapy
|
WO2024081820A1
(en)
|
2022-10-13 |
2024-04-18 |
Sana Biotechnology, Inc. |
Viral particles targeting hematopoietic stem cells
|
WO2024083579A1
(en)
|
2022-10-20 |
2024-04-25 |
Basf Se |
Regulatory nucleic acid molecules for enhancing gene expression in plants
|
WO2024098027A1
(en)
|
2022-11-04 |
2024-05-10 |
Iovance Biotherapeutics, Inc. |
Methods for tumor infiltrating lymphocyte (til) expansion related to cd39/cd103 selection
|
WO2024098024A1
(en)
|
2022-11-04 |
2024-05-10 |
Iovance Biotherapeutics, Inc. |
Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof
|
WO2024102434A1
(en)
|
2022-11-10 |
2024-05-16 |
Senda Biosciences, Inc. |
Rna compositions comprising lipid nanoparticles or lipid reconstructed natural messenger packs
|
WO2024112571A2
(en)
|
2022-11-21 |
2024-05-30 |
Iovance Biotherapeutics, Inc. |
Two-dimensional processes for the expansion of tumor infiltrating lymphocytes and therapies therefrom
|
WO2024118836A1
(en)
|
2022-11-30 |
2024-06-06 |
Iovance Biotherapeutics, Inc. |
Processes for production of tumor infiltrating lymphocytes with shortened rep step
|
WO2024119157A1
(en)
|
2022-12-02 |
2024-06-06 |
Sana Biotechnology, Inc. |
Lipid particles with cofusogens and methods of producing and using the same
|
WO2024123786A1
(en)
|
2022-12-06 |
2024-06-13 |
Pioneer Hi-Bred International, Inc. |
Methods and compositions for co-delivery of t-dnas expressing multiple guide polynucleotides into plants
|
WO2024138194A1
(en)
|
2022-12-22 |
2024-06-27 |
Tome Biosciences, Inc. |
Platforms, compositions, and methods for in vivo programmable gene insertion
|
WO2024137259A1
(en)
|
2022-12-23 |
2024-06-27 |
Pivot Bio, Inc. |
Combination of various nitrogen fixing bacteria with various biological products to achieve synergistic effects
|
WO2024141599A1
(en)
|
2022-12-29 |
2024-07-04 |
Vilmorin & Cie |
Tomato plants resistant to resistance-breaking tswv strains and corresponding resistance genes
|
WO2024155745A1
(en)
|
2023-01-18 |
2024-07-25 |
The Broad Institute, Inc. |
Base editing-mediated readthrough of premature termination codons (bert)
|
WO2024161358A1
(en)
|
2023-02-01 |
2024-08-08 |
Dlf Seeds A/S |
Beet yellows virus resistance
|
WO2024168265A1
(en)
|
2023-02-10 |
2024-08-15 |
Possible Medicines Llc |
Aav delivery of rna guided recombination system
|
WO2024168253A1
(en)
|
2023-02-10 |
2024-08-15 |
Possible Medicines Llc |
Delivery of an rna guided recombination system
|
US20240301447A1
(en)
|
2023-02-15 |
2024-09-12 |
Arbor Biotechnologies, Inc. |
Gene editing method for inhibiting aberrant splicing in stathmin 2 (stmn2) transcript
|
WO2024196921A1
(en)
|
2023-03-20 |
2024-09-26 |
Pioneer Hi-Bred International, Inc. |
Cas polypeptides with altered pam recognition
|
US20240324538A1
(en)
|
2023-03-27 |
2024-10-03 |
Red Sea Farms Ltd |
Tomato plant designated 'x21-02'
|
WO2024206687A1
(en)
*
|
2023-03-29 |
2024-10-03 |
William Marsh Rice University |
Methods and compostions for engineered mitochondrial biogenesis
|
WO2024206911A2
(en)
|
2023-03-30 |
2024-10-03 |
Children's Hospital Medical Center |
Clinical-grade organoids
|
WO2024211287A1
(en)
|
2023-04-03 |
2024-10-10 |
Seagen Inc. |
Production cell lines with targeted integration sites
|
WO2024220598A2
(en)
|
2023-04-18 |
2024-10-24 |
Sana Biotechnology, Inc. |
Lentiviral vectors with two or more genomes
|
WO2024220719A1
(en)
|
2023-04-18 |
2024-10-24 |
Crystal Ronald G |
Modified aav capsids for gene delivery
|
WO2024220574A1
(en)
|
2023-04-18 |
2024-10-24 |
Sana Biotechnology, Inc. |
Universal protein g fusogens and adapter systems thereof and related lipid particles and uses
|
WO2024220560A1
(en)
|
2023-04-18 |
2024-10-24 |
Sana Biotechnology, Inc. |
Engineered protein g fusogens and related lipid particles and methods thereof
|
US20240352485A1
(en)
|
2023-04-19 |
2024-10-24 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and methods for the production of libraries
|
WO2024218295A1
(en)
|
2023-04-21 |
2024-10-24 |
Vib Vzw |
Allelic combinations in crops for yield increase
|
WO2024226499A1
(en)
|
2023-04-24 |
2024-10-31 |
The Broad Institute, Inc. |
Compositions and methods for modifying fertility
|
WO2024223900A1
(en)
|
2023-04-28 |
2024-10-31 |
Vilmorin & Cie |
Genetic determinants conferring improved tobrfv resistance
|
WO2024234006A1
(en)
|
2023-05-11 |
2024-11-14 |
Tome Biosciences, Inc. |
Systems, compositions, and methods for targeting liver sinusodial endothelial cells (lsecs)
|
WO2024236547A1
(en)
|
2023-05-18 |
2024-11-21 |
Inceptor Bio, Llc |
Modified phagocytic cells expressing chimeric antigen receptors comprising a herpes virus entry mediator (hvem) co-stimulatory domain and uses thereof
|
WO2024238977A2
(en)
|
2023-05-18 |
2024-11-21 |
Children's Hospital Medical Center |
Liver organoids with intrahepatic sympathetic nerves, and methods of use thereof
|
WO2024243438A2
(en)
|
2023-05-23 |
2024-11-28 |
Omega Therapeutics, Inc. |
Compositions and methods for reducing cxcl9, cxcl10, and cxcl11 gene expression
|
WO2024243340A1
(en)
|
2023-05-23 |
2024-11-28 |
Sana Biotechnology, Inc. |
Tandem fusogens and related lipid particles
|
WO2024263961A2
(en)
|
2023-06-23 |
2024-12-26 |
Children's Hospital Medical Center |
Methods of matrix-free suspension culture
|
US20240425868A1
(en)
|
2023-06-26 |
2024-12-26 |
Flagship Pioneering Innovations Vii, Llc |
Engineered plasmodia and related methods
|
WO2025003305A1
(en)
|
2023-06-28 |
2025-01-02 |
Vilmorin & Cie |
Pepper resistance to meloidogyne enterolobii
|
WO2025021893A1
(en)
|
2023-07-24 |
2025-01-30 |
Vilmorin & Cie |
Resistance to cysdv in melons
|
WO2025027166A1
(en)
|
2023-08-01 |
2025-02-06 |
Basf Plant Science Company Gmbh |
Increased resistance by expression of msbp1 protein
|
WO2025027165A1
(en)
|
2023-08-01 |
2025-02-06 |
Basf Plant Science Company Gmbh |
Increased resistance by expression of an ics protein
|
WO2025030048A2
(en)
|
2023-08-03 |
2025-02-06 |
J.R. Simplot Company |
Fusarium wilt resistance genes
|
US20250059551A1
(en)
|
2023-08-14 |
2025-02-20 |
The Texas A&M University System |
Corn endotype-derived polypeptides capable of metabolizing fumonisin
|