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CY1113984T1 - Προϊοντα συζευξης μεϋτανσινοειδους dm1 με αντισωμα trastuzumab, συνδεδεμενα μεσω μη-διασπασιμου συνδετηρα και χρηση αυτων στη θεραπεια ογκων - Google Patents

Προϊοντα συζευξης μεϋτανσινοειδους dm1 με αντισωμα trastuzumab, συνδεδεμενα μεσω μη-διασπασιμου συνδετηρα και χρηση αυτων στη θεραπεια ογκων

Info

Publication number
CY1113984T1
CY1113984T1 CY20131100372T CY131100372T CY1113984T1 CY 1113984 T1 CY1113984 T1 CY 1113984T1 CY 20131100372 T CY20131100372 T CY 20131100372T CY 131100372 T CY131100372 T CY 131100372T CY 1113984 T1 CY1113984 T1 CY 1113984T1
Authority
CY
Cyprus
Prior art keywords
conjugate
treatment
extractive
connector
trastuzumab antibody
Prior art date
Application number
CY20131100372T
Other languages
English (en)
Inventor
Rita Steeves
Robert Lutz
Ravi Chari
Hongsheng Xie
Yelena Kovtun
Original Assignee
Immunogen, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34467962&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1113984(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Immunogen, Inc. filed Critical Immunogen, Inc.
Publication of CY1113984T1 publication Critical patent/CY1113984T1/el

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Abstract

Η παρούσα εφεύρεση αποκαλύπτει μια μέθοδο για στοχοθέτηση μεϋτανσινοειδών σε έναν επιλεγέντα πληθυσμό κυττάρου, τη μέθοδο που περιλαμβάνει επαφή ενός πληθυσμού κυττάρου ή ιστού που υποπτευόμαστε ότι περιέχει τον επιλεγέντα πληθυσμό κυττάρου με έναν παράγοντα σύνθεσης κυττάρου προϊόντος σύζευξης με μεϋτανσινοειδές, όπου ένα ή περισσότερα μεϋτανσινοειδή συνδέονται ομοιοπολικώς προς έναν παράγοντα σύνδεσης κυττάρου μέσω μη-διασπάσιμου συνδετήρα και ο παράγων σύνδεσης κυττάρου συνδέεται προς κύτταρα του επιλεγέντος πληθυσμού κυττάρου.
CY20131100372T 2003-10-10 2013-05-08 Προϊοντα συζευξης μεϋτανσινοειδους dm1 με αντισωμα trastuzumab, συνδεδεμενα μεσω μη-διασπασιμου συνδετηρα και χρηση αυτων στη θεραπεια ογκων CY1113984T1 (el)

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US50990103P 2003-10-10 2003-10-10
US10/960,602 US8088387B2 (en) 2003-10-10 2004-10-08 Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
EP04793896A EP1689846B1 (en) 2003-10-10 2004-10-12 Conjugates of maytansinoid DM1 with antibody trastuzumab, linked through a non-cleavable linker, and its use in the treatment of tumours

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CY2014002C CY2014002I1 (el) 2003-10-10 2014-01-16 Προϊοντα συζευξης μεϋτανσινοειδους dm1 με αντισωμα trastuzumab, συνδεδεμενα μεσω μη-διασπασιμου συνδετηρα και χρηση αυτων στη θεραπεια ογκων

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