BRPI0515089B8 - derivados halogenados de benzamida - Google Patents
derivados halogenados de benzamidaInfo
- Publication number
- BRPI0515089B8 BRPI0515089B8 BRPI0515089A BRPI0515089A BRPI0515089B8 BR PI0515089 B8 BRPI0515089 B8 BR PI0515089B8 BR PI0515089 A BRPI0515089 A BR PI0515089A BR PI0515089 A BRPI0515089 A BR PI0515089A BR PI0515089 B8 BRPI0515089 B8 BR PI0515089B8
- Authority
- BR
- Brazil
- Prior art keywords
- benzamide derivatives
- halogenated benzamide
- halogenated
- alkyl
- iii
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
derivados halogenados de benzamida. a presente invenção se refere a um derivado halogenado de benzamida, de acordo com a fórmula (iii): (iii) caracterizado por apresentar uma maior especificidade para patógenos virais e um menor poder de ruptura, de modo a beneficiar a microflora do intestino, em que r1 representa um átomo de halogênio e r2-r6 representam, independentemente, hidrogênio, hidroxila, c1-c4 alquila, c1-c4 alcóxi, acilóxi, nitro, halogênio, -c(o)r7, onde r7 representa c1- c4 alquila ou um composto aromático, incluindo os sais e hidratos desses compostos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60835404P | 2004-09-09 | 2004-09-09 | |
| US60/608,354 | 2004-09-09 | ||
| PCT/US2005/031868 WO2006031566A2 (en) | 2004-09-09 | 2005-09-06 | Halogenated benzamide derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0515089A BRPI0515089A (pt) | 2008-07-08 |
| BRPI0515089B1 BRPI0515089B1 (pt) | 2019-07-16 |
| BRPI0515089B8 true BRPI0515089B8 (pt) | 2021-05-25 |
Family
ID=36060542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0515089A BRPI0515089B8 (pt) | 2004-09-09 | 2005-09-06 | derivados halogenados de benzamida |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US7285567B2 (pt) |
| EP (1) | EP1789040B1 (pt) |
| JP (1) | JP4998852B2 (pt) |
| KR (1) | KR101344984B1 (pt) |
| CN (1) | CN101035531B (pt) |
| AP (1) | AP2451A (pt) |
| AU (1) | AU2005285157B2 (pt) |
| BR (1) | BRPI0515089B8 (pt) |
| CA (1) | CA2580347C (pt) |
| CY (1) | CY1118689T1 (pt) |
| DK (1) | DK1789040T3 (pt) |
| EA (1) | EA012606B1 (pt) |
| ES (1) | ES2559672T3 (pt) |
| HK (1) | HK1106139A1 (pt) |
| HR (1) | HRP20151439T1 (pt) |
| HU (1) | HUE026613T2 (pt) |
| IL (2) | IL181849A (pt) |
| ME (1) | ME02370B (pt) |
| MX (1) | MX2007002969A (pt) |
| PL (1) | PL1789040T3 (pt) |
| PT (1) | PT1789040E (pt) |
| RS (1) | RS54453B1 (pt) |
| SI (1) | SI1789040T1 (pt) |
| UA (1) | UA90864C2 (pt) |
| WO (1) | WO2006031566A2 (pt) |
| ZA (1) | ZA200702066B (pt) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE375980T1 (de) * | 2002-02-12 | 2007-11-15 | Smithkline Beecham Corp | Nicotinamide und deren verwendung als p38 inhibitoren |
| UA90864C2 (en) * | 2004-09-09 | 2010-06-10 | Ромарк Лебораториз, Л.К. | Halogenated benzamide derivatives |
| EP1871365A2 (en) * | 2005-04-12 | 2008-01-02 | Romark Laboratories, L.C. | Methods for treating diseases through inhibition the function of molecular chaperones such as protein disulfide isomerases , pharmaceutical compositions comprising them, and screening methods for identifying therapeutic agents |
| US8633230B2 (en) * | 2006-01-09 | 2014-01-21 | Jean-Francois Rossignol | Viral hepatitis treatment |
| CA2695517C (en) | 2007-08-03 | 2016-09-20 | J. Edward Semple | Alkylsulfonyl-substituted thiazolide compounds |
| ES2797493T3 (es) | 2009-02-13 | 2020-12-02 | Romark Laboratories Lc | Formulaciones farmacéuticas de liberación controlada de nitazoxanida |
| NZ596538A (en) * | 2009-05-12 | 2014-04-30 | Romark Lab Lc | Haloalkyl heteroaryl benzamide compounds |
| BR122020003634B8 (pt) * | 2009-06-26 | 2021-07-27 | Romark Laboratories Lc | uso de nitazoxanida, tizoxanida ou sal farmaceuticalmente aceitável do mesmo no tratamento de uma doença semelhante a influenza |
| CN102335171B (zh) * | 2010-07-27 | 2013-09-11 | 中国农业科学院上海兽医研究所 | 一类n-(2-噻唑)苯甲酰胺衍生物的应用 |
| JP6138764B2 (ja) | 2011-05-16 | 2017-05-31 | ロマーク ラボラトリーズ エル．シー． | ウイルス性疾患、ガンおよび細胞内感染により引き起こされる疾患の予防および処置のためのチアゾリド化合物の使用 |
| WO2014052831A1 (en) * | 2012-09-28 | 2014-04-03 | Xavier University Of Louisiana | Anti-migration and anti-invasion thiazole analogs for treatment of cellular proliferative disease |
| MX2017006083A (es) | 2014-11-11 | 2017-11-08 | Romark Laboratories Lc | Composicones y metodos de tratamiento con profarmacos de tizoxanida, un analogo o sal de la misma. |
| LT3436074T (lt) | 2016-03-31 | 2020-09-25 | Romark Laboratories, L.C. | Tiazolido junginiai, skirti virusinių infekcijų gydymui |
| DK3777855T3 (da) | 2016-04-11 | 2023-01-09 | Genfit | Fremgangsmåder til behandling af fibrotiske sygdomme |
| US11173149B2 (en) | 2017-04-18 | 2021-11-16 | Romark Laboratories L.C. | Inhibition of protein disulfide-isomerase A3 |
| EP4182304A1 (en) | 2020-07-20 | 2023-05-24 | Romark Laboratories, L.C. | Crystalline salts of tizoxanide and 2-hydroxy-n-(5-chloro-1,3-thiazol-2-yl)benzamide (rm-4848) with ethanolamine, morpholine, propanolamine, piperazine and n-methylpiperazine |
| CN116367892A (zh) | 2020-08-24 | 2023-06-30 | 罗马克实验室有限公司 | 噻唑化物抗冠状病毒的用途 |
| CN115197164A (zh) * | 2021-04-12 | 2022-10-18 | 杜心赟 | 新型噻唑类化合物及其制备方法和用途 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1276663A (en) * | 1968-12-24 | 1972-06-07 | Ici Ltd | Stimulation of plant growth |
| PH9683A (en) * | 1970-04-15 | 1976-02-10 | P Haken | Carboxamide derivatives and the use as fungicides thereof |
| GB1437800A (en) | 1973-08-08 | 1976-06-03 | Phavic Sprl | Derivatives of 2-benzamido-5-nitro-thiazoles |
| US4315018A (en) | 1978-12-07 | 1982-02-09 | Rossignol Jean F | Specific parasiticidal use of 2-benzamido-5-nitro-thiazole derivatives |
| JPS60205454A (ja) * | 1984-03-29 | 1985-10-17 | Mitsubishi Paper Mills Ltd | 電子写真感光体 |
| US5169846A (en) | 1989-10-12 | 1992-12-08 | Crooks Michael J | Non-aqueous micellar solutions of anthelmintic benzimidazoles, closantel, or phenothiazine, and insect growth regulators |
| US5578612A (en) * | 1990-10-15 | 1996-11-26 | Pfizer Inc. | Indole derivatives |
| US5578621A (en) | 1994-09-08 | 1996-11-26 | Romark Lab Lc | Benzamide derivatives |
| AP645A (en) * | 1994-04-13 | 1998-04-24 | Romark Laboratories Lc | Benzamine derivative, compositions containing said derivative and use thereof. |
| US5387598A (en) | 1994-04-13 | 1995-02-07 | Rossignol; Jean-Francois | Composition and galenic formulation suitable for combatting affections of the lower abdomen |
| US5859038A (en) | 1994-09-08 | 1999-01-12 | Romark Laboratories, L.C. | Method for treatment of helicobacter pylori infections |
| MX9604483A (es) | 1994-09-08 | 1998-02-28 | Jean-Francois Rossignol | Derivados de benzamida, composiciones que contienen dicho derivado y uso de las mismas. |
| US5856348A (en) | 1994-09-08 | 1999-01-05 | Romark Laboratories, L.C. | Method for treatment of trematodes with pharmaceutical compositions of tizoxanide and nitazoxanide |
| US5968961A (en) | 1997-05-07 | 1999-10-19 | Romark Laboratories, L.C. | Pharmaceutical compositions of tizoxanide and nitazoxanide |
| US5965590A (en) | 1994-09-08 | 1999-10-12 | Romark Lab Lc | Method for treatment of opportunistic infections with pharmaceutical compositions of tizoxanide and nitazoxanide |
| DE19528046A1 (de) * | 1994-11-21 | 1996-05-23 | Bayer Ag | Triazolyl-Derivate |
| US5935591A (en) * | 1998-01-15 | 1999-08-10 | Romark Laboratories, L.C. | Method for treatment of equine protozoal myeloencephalitis with thiazolides |
| GB9823871D0 (en) * | 1998-10-30 | 1998-12-23 | Pharmacia & Upjohn Spa | 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents |
| PL357678A1 (en) * | 2000-04-28 | 2004-07-26 | Sankyo Company, Limited | Ppargamma modulators |
| BR0111997A (pt) * | 2000-07-14 | 2003-05-20 | Breed Automotive Tech | Retrator de cinto de segurança |
| KR20090090406A (ko) * | 2000-12-18 | 2009-08-25 | 가부시키가이샤 이야쿠 분지 셋케이 겐쿠쇼 | 염증성 사이토카인 생산 유리 억제제 |
| JP2003064056A (ja) * | 2001-08-27 | 2003-03-05 | Sankyo Co Ltd | アミド誘導体 |
| WO2003035602A1 (fr) * | 2001-10-25 | 2003-05-01 | Sankyo Company, Limited | Modulateurs lipidiques |
| JP4660674B2 (ja) * | 2002-06-06 | 2011-03-30 | 株式会社医薬分子設計研究所 | 抗アレルギー薬 |
| US6737382B1 (en) * | 2002-10-23 | 2004-05-18 | Nippon Soda Co. Ltd. | Insecticidal aminothiazole derivatives |
| EA011402B1 (ru) * | 2004-01-23 | 2009-02-27 | Эмджен Инк. | Азотсодержащие гетероциклические производные и их фармацевтические применения |
| UA90864C2 (en) * | 2004-09-09 | 2010-06-10 | Ромарк Лебораториз, Л.К. | Halogenated benzamide derivatives |
-
2005
- 2005-06-09 UA UAA200702713A patent/UA90864C2/ru unknown
- 2005-09-06 MX MX2007002969A patent/MX2007002969A/es active IP Right Grant
- 2005-09-06 RS RS20160058A patent/RS54453B1/en unknown
- 2005-09-06 AP AP2007003950A patent/AP2451A/xx active
- 2005-09-06 EA EA200700432A patent/EA012606B1/ru not_active IP Right Cessation
- 2005-09-06 HU HUE05800142A patent/HUE026613T2/hu unknown
- 2005-09-06 ZA ZA200702066A patent/ZA200702066B/xx unknown
- 2005-09-06 PT PT58001421T patent/PT1789040E/pt unknown
- 2005-09-06 BR BRPI0515089A patent/BRPI0515089B8/pt not_active IP Right Cessation
- 2005-09-06 EP EP05800142.1A patent/EP1789040B1/en active Active
- 2005-09-06 WO PCT/US2005/031868 patent/WO2006031566A2/en active Application Filing
- 2005-09-06 ES ES05800142.1T patent/ES2559672T3/es active Active
- 2005-09-06 AU AU2005285157A patent/AU2005285157B2/en not_active Ceased
- 2005-09-06 SI SI200532034T patent/SI1789040T1/sl unknown
- 2005-09-06 ME MEP-2016-7A patent/ME02370B/me unknown
- 2005-09-06 PL PL05800142T patent/PL1789040T3/pl unknown
- 2005-09-06 JP JP2007531304A patent/JP4998852B2/ja not_active Expired - Fee Related
- 2005-09-06 US US11/221,256 patent/US7285567B2/en active Active
- 2005-09-06 CA CA2580347A patent/CA2580347C/en not_active Expired - Fee Related
- 2005-09-06 DK DK05800142.1T patent/DK1789040T3/en active
- 2005-09-06 CN CN2005800338784A patent/CN101035531B/zh not_active Expired - Fee Related
-
2007
- 2007-03-11 IL IL181849A patent/IL181849A/en not_active IP Right Cessation
- 2007-03-29 KR KR1020077007159A patent/KR101344984B1/ko active IP Right Grant
- 2007-10-01 US US11/865,532 patent/US7645783B2/en active Active
- 2007-10-01 US US11/865,541 patent/US7550493B2/en active Active
- 2007-10-24 HK HK07111470.9A patent/HK1106139A1/zh not_active IP Right Cessation
-
2009
- 2009-12-29 IL IL203061A patent/IL203061A/en active IP Right Grant
-
2015
- 2015-12-30 HR HRP20151439TT patent/HRP20151439T1/hr unknown
-
2016
- 2016-01-20 CY CY20161100061T patent/CY1118689T1/el unknown
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Legal Events
| Date | Code | Title | Description |
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
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| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
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| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2686 DE 28-06-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |