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ZA200702066B - Halogenated benzmide derivatives - Google Patents

Halogenated benzmide derivatives

Info

Publication number
ZA200702066B
ZA200702066B ZA200702066A ZA200702066A ZA200702066B ZA 200702066 B ZA200702066 B ZA 200702066B ZA 200702066 A ZA200702066 A ZA 200702066A ZA 200702066 A ZA200702066 A ZA 200702066A ZA 200702066 B ZA200702066 B ZA 200702066B
Authority
ZA
South Africa
Prior art keywords
benzmide
halogenated
derivatives
halogenated benzmide
benzmide derivatives
Prior art date
Application number
ZA200702066A
Other languages
English (en)
Inventor
Rossignol Jean Francois
Original Assignee
Romark Lab Lc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Romark Lab Lc filed Critical Romark Lab Lc
Publication of ZA200702066B publication Critical patent/ZA200702066B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
ZA200702066A 2004-09-09 2005-09-06 Halogenated benzmide derivatives ZA200702066B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60835404P 2004-09-09 2004-09-09

Publications (1)

Publication Number Publication Date
ZA200702066B true ZA200702066B (en) 2008-08-27

Family

ID=36060542

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200702066A ZA200702066B (en) 2004-09-09 2005-09-06 Halogenated benzmide derivatives

Country Status (26)

Country Link
US (3) US7285567B2 (xx)
EP (1) EP1789040B1 (xx)
JP (1) JP4998852B2 (xx)
KR (1) KR101344984B1 (xx)
CN (1) CN101035531B (xx)
AP (1) AP2451A (xx)
AU (1) AU2005285157B2 (xx)
BR (1) BRPI0515089B8 (xx)
CA (1) CA2580347C (xx)
CY (1) CY1118689T1 (xx)
DK (1) DK1789040T3 (xx)
EA (1) EA012606B1 (xx)
ES (1) ES2559672T3 (xx)
HK (1) HK1106139A1 (xx)
HR (1) HRP20151439T1 (xx)
HU (1) HUE026613T2 (xx)
IL (2) IL181849A (xx)
ME (1) ME02370B (xx)
MX (1) MX2007002969A (xx)
PL (1) PL1789040T3 (xx)
PT (1) PT1789040E (xx)
RS (1) RS54453B1 (xx)
SI (1) SI1789040T1 (xx)
UA (1) UA90864C2 (xx)
WO (1) WO2006031566A2 (xx)
ZA (1) ZA200702066B (xx)

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PT1864975E (pt) * 2002-02-12 2010-12-27 Glaxosmithkline Llc Derivados de nicotinamida úteis como inibidores de p38
UA90864C2 (xx) * 2004-09-09 2010-06-10 Ромарк Лебораториз, Л.К. Галогенізовані похідні бензаміду$галогенизированные производные бензамида
EP1871365A2 (en) * 2005-04-12 2008-01-02 Romark Laboratories, L.C. Methods for treating diseases through inhibition the function of molecular chaperones such as protein disulfide isomerases , pharmaceutical compositions comprising them, and screening methods for identifying therapeutic agents
AP2907A (en) * 2006-01-09 2014-05-31 Romark Lab Lc Viral hepatitis treatment
EP2178852B9 (en) 2007-08-03 2016-06-22 Romark Laboratories, L.C. Alkylsulfonyl-substituted thiazolide compounds
CA2752233C (en) * 2009-02-13 2017-01-03 Romark Laboratories L.C. Controlled release pharmaceutical formulations of nitazoxanide
CN102803203B (zh) 2009-05-12 2016-05-11 罗马克实验室有限公司 卤代烷基杂芳基苯甲酰胺化合物
AU2010264479B2 (en) * 2009-06-26 2017-06-01 Romark Laboratories L.C. Compounds and methods for treating influenza
CN102335171B (zh) * 2010-07-27 2013-09-11 中国农业科学院上海兽医研究所 一类n-(2-噻唑)苯甲酰胺衍生物的应用
DK2709453T3 (da) 2011-05-16 2020-01-20 Romark Laboratories Lc Anvendelse af thiazolid-forbindelser til forebyggelse og behandling af virussygdomme, cancer og sygdomme forårsaget af intracellulære infektioner
US9650369B2 (en) * 2012-09-28 2017-05-16 Xavier University Of Louisiana Anti-migration and anti-invasion thiazole analogs for treatment of cellular proliferative disease
TW201619142A (zh) 2014-11-11 2016-06-01 羅馬克實驗室有限公司 利用替唑尼特（ｔｉｚｏｘａｎｉｄｅ）、其類似物或鹽類之前驅藥的組成物及治療方法
EA036505B1 (ru) * 2016-03-31 2020-11-18 Ромарк Лабораториз Л.С. Способ лечения заболевания или состояния, вызванного вирусом, принадлежащим к роду enterovirus
SI3442580T1 (sl) 2016-04-11 2021-01-29 Genfit Metode zdravljenja holestatičnih in fibrotičnih bolezni
US11173149B2 (en) 2017-04-18 2021-11-16 Romark Laboratories L.C. Inhibition of protein disulfide-isomerase A3
CA3186666A1 (en) 2020-07-20 2022-01-27 Jean-Francois Rossignol Crystalline salts of tizoxanide and 2-hydroxy-n-(5-chloro-1,3-thiazol-2-yl)benzamide (rm-4848) with ethanolamine, morpholine, propanolamine, piperazine and n-methylpiperazine
EP4199923A1 (en) 2020-08-24 2023-06-28 Romark Laboratories, L.C. Use of thiazolides against coronaviruses
CN115197164B (zh) * 2021-04-12 2025-04-01 杜心赟 新型噻唑类化合物及其制备方法和用途

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GB1276663A (en) 1968-12-24 1972-06-07 Ici Ltd Stimulation of plant growth
ZA712295B (en) 1970-04-15 1972-01-26 Shell Int Research Fungicidal compounds
GB1437800A (en) 1973-08-08 1976-06-03 Phavic Sprl Derivatives of 2-benzamido-5-nitro-thiazoles
US4315018A (en) 1978-12-07 1982-02-09 Rossignol Jean F Specific parasiticidal use of 2-benzamido-5-nitro-thiazole derivatives
JPS60205454A (ja) * 1984-03-29 1985-10-17 Mitsubishi Paper Mills Ltd 電子写真感光体
US5169846A (en) 1989-10-12 1992-12-08 Crooks Michael J Non-aqueous micellar solutions of anthelmintic benzimidazoles, closantel, or phenothiazine, and insect growth regulators
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
CZ287002B6 (en) 1994-04-13 2000-08-16 Rossignol Jean Franaois Benzamide derivative, pharmaceutical preparation containing thereof and use of the derivative
US5387598A (en) 1994-04-13 1995-02-07 Rossignol; Jean-Francois Composition and galenic formulation suitable for combatting affections of the lower abdomen
US5578621A (en) 1994-09-08 1996-11-26 Romark Lab Lc Benzamide derivatives
US5856348A (en) 1994-09-08 1999-01-05 Romark Laboratories, L.C. Method for treatment of trematodes with pharmaceutical compositions of tizoxanide and nitazoxanide
MX9604483A (es) 1994-09-08 1998-02-28 Jean-Francois Rossignol Derivados de benzamida, composiciones que contienen dicho derivado y uso de las mismas.
US5965590A (en) 1994-09-08 1999-10-12 Romark Lab Lc Method for treatment of opportunistic infections with pharmaceutical compositions of tizoxanide and nitazoxanide
US5968961A (en) 1997-05-07 1999-10-19 Romark Laboratories, L.C. Pharmaceutical compositions of tizoxanide and nitazoxanide
US5859038A (en) 1994-09-08 1999-01-12 Romark Laboratories, L.C. Method for treatment of helicobacter pylori infections
DE19528046A1 (de) * 1994-11-21 1996-05-23 Bayer Ag Triazolyl-Derivate
US5935591A (en) 1998-01-15 1999-08-10 Romark Laboratories, L.C. Method for treatment of equine protozoal myeloencephalitis with thiazolides
GB9823871D0 (en) * 1998-10-30 1998-12-23 Pharmacia & Upjohn Spa 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents
PL357678A1 (en) * 2000-04-28 2004-07-26 Sankyo Company, Limited Ppargamma modulators
EP1301378A1 (en) * 2000-07-14 2003-04-16 Breed Automotive Technology, Inc. Energy absorbing seat belt retractor
UA82827C2 (en) * 2000-12-18 2008-05-26 Inhibitors against the production and release of inflammatory cytokines
JP2003064056A (ja) * 2001-08-27 2003-03-05 Sankyo Co Ltd アミド誘導体
WO2003035602A1 (fr) * 2001-10-25 2003-05-01 Sankyo Company, Limited Modulateurs lipidiques
US20060122243A1 (en) * 2002-06-06 2006-06-08 Susumu Muto Antiallergic
US6737382B1 (en) * 2002-10-23 2004-05-18 Nippon Soda Co. Ltd. Insecticidal aminothiazole derivatives
WO2005070891A2 (en) * 2004-01-23 2005-08-04 Amgen Inc Compounds and methods of use
UA90864C2 (xx) * 2004-09-09 2010-06-10 Ромарк Лебораториз, Л.К. Галогенізовані похідні бензаміду$галогенизированные производные бензамида

Also Published As

Publication number Publication date
AU2005285157A1 (en) 2006-03-23
US20080097106A1 (en) 2008-04-24
JP4998852B2 (ja) 2012-08-15
SI1789040T1 (sl) 2016-02-29
JP2008512474A (ja) 2008-04-24
IL181849A0 (en) 2007-07-04
ME02370B (me) 2016-06-20
HK1106139A1 (zh) 2008-03-07
AU2005285157B2 (en) 2009-07-16
MX2007002969A (es) 2008-02-15
CN101035531B (zh) 2013-01-02
US20080096941A1 (en) 2008-04-24
WO2006031566A2 (en) 2006-03-23
US20060089396A1 (en) 2006-04-27
RS54453B1 (en) 2016-06-30
ES2559672T3 (es) 2016-02-15
EA012606B1 (ru) 2009-10-30
BRPI0515089A (pt) 2008-07-08
UA90864C2 (xx) 2010-06-10
DK1789040T3 (en) 2016-02-01
KR101344984B1 (ko) 2013-12-24
CY1118689T1 (el) 2017-07-12
EP1789040A4 (en) 2009-09-02
PT1789040E (pt) 2016-02-19
US7285567B2 (en) 2007-10-23
US7645783B2 (en) 2010-01-12
EP1789040A2 (en) 2007-05-30
BRPI0515089B8 (pt) 2021-05-25
CA2580347C (en) 2013-12-10
US7550493B2 (en) 2009-06-23
IL181849A (en) 2013-11-28
WO2006031566A3 (en) 2006-06-08
PL1789040T3 (pl) 2016-04-29
HUE026613T2 (hu) 2016-06-28
BRPI0515089B1 (pt) 2019-07-16
HRP20151439T1 (hr) 2016-02-12
KR20070052330A (ko) 2007-05-21
CA2580347A1 (en) 2006-03-23
EP1789040B1 (en) 2015-12-23
AP2451A (en) 2012-08-31
IL203061A (en) 2013-04-30
AP2007003950A0 (en) 2007-04-30
EA200700432A1 (ru) 2007-10-26
CN101035531A (zh) 2007-09-12

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