[go: up one dir, main page]

EA200700432A1 - Галогенированные производные бензамида - Google Patents

Галогенированные производные бензамида

Info

Publication number
EA200700432A1
EA200700432A1 EA200700432A EA200700432A EA200700432A1 EA 200700432 A1 EA200700432 A1 EA 200700432A1 EA 200700432 A EA200700432 A EA 200700432A EA 200700432 A EA200700432 A EA 200700432A EA 200700432 A1 EA200700432 A1 EA 200700432A1
Authority
EA
Eurasian Patent Office
Prior art keywords
benzamide derivatives
6alkyl
halogenated benzamide
halogenated
halogen
Prior art date
Application number
EA200700432A
Other languages
English (en)
Other versions
EA012606B1 (ru
Inventor
Жан Франсуа Россиньоль
Original Assignee
Ромарк Лабораториз, Л.С.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ромарк Лабораториз, Л.С. filed Critical Ромарк Лабораториз, Л.С.
Publication of EA200700432A1 publication Critical patent/EA200700432A1/ru
Publication of EA012606B1 publication Critical patent/EA012606B1/ru

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/4261,3-Thiazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38Nitrogen atoms
    • C07D277/44Acylated amino or imino radicals
    • C07D277/46Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38Nitrogen atoms
    • C07D277/44Acylated amino or imino radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Галогенированные производные бензамида, характеризующиеся более высокой специфичностью к вирусным патогенам и менее разрушительные для полезной микрофлоры пищеварительного тракта, имеющие формулу (III), где Rпредставляет собой атом галогена и R-Rнезависимо представляют собой водород, гидроксил, С-Салкил, -С-Салкокси, ацилокси, нитро, галоген, -C(O)R, где Rпредставляет собой -С-Салкил, или ароматический радикал, включая соли и гидраты этих соединений.
EA200700432A 2004-09-09 2005-09-06 Галогенированные производные бензамида EA012606B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60835404P 2004-09-09 2004-09-09
PCT/US2005/031868 WO2006031566A2 (en) 2004-09-09 2005-09-06 Halogenated benzamide derivatives

Publications (2)

Publication Number Publication Date
EA200700432A1 true EA200700432A1 (ru) 2007-10-26
EA012606B1 EA012606B1 (ru) 2009-10-30

Family

ID=36060542

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200700432A EA012606B1 (ru) 2004-09-09 2005-09-06 Галогенированные производные бензамида

Country Status (25)

Country Link
US (3) US7285567B2 (ru)
EP (1) EP1789040B1 (ru)
JP (1) JP4998852B2 (ru)
KR (1) KR101344984B1 (ru)
CN (1) CN101035531B (ru)
AP (1) AP2451A (ru)
AU (1) AU2005285157B2 (ru)
BR (1) BRPI0515089B8 (ru)
CA (1) CA2580347C (ru)
CY (1) CY1118689T1 (ru)
DK (1) DK1789040T3 (ru)
EA (1) EA012606B1 (ru)
ES (1) ES2559672T3 (ru)
HR (1) HRP20151439T1 (ru)
HU (1) HUE026613T2 (ru)
IL (2) IL181849A (ru)
ME (1) ME02370B (ru)
MX (1) MX2007002969A (ru)
PL (1) PL1789040T3 (ru)
PT (1) PT1789040E (ru)
RS (1) RS54453B1 (ru)
SI (1) SI1789040T1 (ru)
UA (1) UA90864C2 (ru)
WO (1) WO2006031566A2 (ru)
ZA (1) ZA200702066B (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA021587B1 (ru) * 2009-05-12 2015-07-30 РОМАРК ЛЭБОРЕТЕРИЗ Эл. Си. Соединения галогеналкилгетероарилбензамида

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA04007838A (es) * 2002-02-12 2004-10-15 Smithkline Beecham Corp Derivados de nicotamida utiles como inhibidores p38.
UA90864C2 (en) * 2004-09-09 2010-06-10 Ромарк Лебораториз, Л.К. Halogenated benzamide derivatives
EP2047850A3 (en) * 2005-04-12 2009-07-29 Romark Laboratories, L.C. Methods for treating diseases through inhibition of the function of molecular chaperones such as protein disulfide isomerases , pharmaceutical compositions comprising them, and screening methods for identifying therapeutic agents
EP1976516B9 (en) * 2006-01-09 2013-10-30 Romark Laboratories, L.C. Viral hepatitis treatment
WO2009035788A1 (en) 2007-08-03 2009-03-19 Romark Laboratories L.C. Alkylsulfonyl-substituted thiazolide compounds
PT2395840T (pt) 2009-02-13 2020-07-06 Romark Laboratories Lc Formulações farmacêuticas de libertação controlada de nitazoxanida
JP5932640B2 (ja) 2009-06-26 2016-06-08 ロマーク ラボラトリーズ エル.シー. インフルエンザを治療するための化合物および方法
CN102335171B (zh) * 2010-07-27 2013-09-11 中国农业科学院上海兽医研究所 一类n-(2-噻唑)苯甲酰胺衍生物的应用
WO2012158699A1 (en) 2011-05-16 2012-11-22 Romark Laboratories, L.C. Use of thiazolide compounds for the prevention and treatment of viral diseases, cancer and diseases caused by intracellular infections
US9650369B2 (en) * 2012-09-28 2017-05-16 Xavier University Of Louisiana Anti-migration and anti-invasion thiazole analogs for treatment of cellular proliferative disease
TW201619142A (zh) 2014-11-11 2016-06-01 羅馬克實驗室有限公司 利用替唑尼特(tizoxanide)、其類似物或鹽類之前驅藥的組成物及治療方法
SI3436074T1 (sl) 2016-03-31 2020-09-30 Romark Laboratories, L.C. Tiazolidne spojine za zdravljenje virusnih infekcij
HUE060671T2 (hu) 2016-04-11 2023-04-28 Genfit Eljárás fibrotikus betegségek kezelésére
WO2018195035A1 (en) 2017-04-18 2018-10-25 Romark Laboratories L.C. Inhibition of protein disulfide-isomerase a3
JP2023537237A (ja) 2020-07-20 2023-08-31 ロマーク ラボラトリーズ,リミティド カンパニー チゾキサニドおよび2-ヒドロキシ-n-(5-クロロ-1,3-チアゾル-2-イル)ベンズアミド(rm-4848)とエタノールアミン、モルホリン、プロパノールアミン、ピペラジン、およびn-メチルピペラジンの結晶塩
US20230330069A1 (en) 2020-08-24 2023-10-19 Romark Laboratories, L.C. Use of thiazolides against coronaviruses
WO2022218239A1 (zh) * 2021-04-12 2022-10-20 杜心赟 新型噻唑类化合物及其制备方法和用途

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1276663A (en) * 1968-12-24 1972-06-07 Ici Ltd Stimulation of plant growth
CA946845A (en) * 1970-04-15 1974-05-07 Shell Internationale Research Maatschappij, N.V. Fungicidal compounds
GB1437800A (en) * 1973-08-08 1976-06-03 Phavic Sprl Derivatives of 2-benzamido-5-nitro-thiazoles
US4315018A (en) 1978-12-07 1982-02-09 Rossignol Jean F Specific parasiticidal use of 2-benzamido-5-nitro-thiazole derivatives
JPS60205454A (ja) * 1984-03-29 1985-10-17 Mitsubishi Paper Mills Ltd 電子写真感光体
US5169846A (en) 1989-10-12 1992-12-08 Crooks Michael J Non-aqueous micellar solutions of anthelmintic benzimidazoles, closantel, or phenothiazine, and insect growth regulators
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5387598A (en) * 1994-04-13 1995-02-07 Rossignol; Jean-Francois Composition and galenic formulation suitable for combatting affections of the lower abdomen
CA2187110C (en) * 1994-04-13 2002-03-19 Jean-Francois Rossignol Benzamide derivative, compositions containing said derivative and use thereof
US5578621A (en) 1994-09-08 1996-11-26 Romark Lab Lc Benzamide derivatives
US5859038A (en) 1994-09-08 1999-01-12 Romark Laboratories, L.C. Method for treatment of helicobacter pylori infections
US5856348A (en) 1994-09-08 1999-01-05 Romark Laboratories, L.C. Method for treatment of trematodes with pharmaceutical compositions of tizoxanide and nitazoxanide
US5968961A (en) 1997-05-07 1999-10-19 Romark Laboratories, L.C. Pharmaceutical compositions of tizoxanide and nitazoxanide
MX9604483A (es) * 1994-09-08 1998-02-28 Jean-Francois Rossignol Derivados de benzamida, composiciones que contienen dicho derivado y uso de las mismas.
US5965590A (en) * 1994-09-08 1999-10-12 Romark Lab Lc Method for treatment of opportunistic infections with pharmaceutical compositions of tizoxanide and nitazoxanide
DE19528046A1 (de) * 1994-11-21 1996-05-23 Bayer Ag Triazolyl-Derivate
US5935591A (en) 1998-01-15 1999-08-10 Romark Laboratories, L.C. Method for treatment of equine protozoal myeloencephalitis with thiazolides
GB9823871D0 (en) * 1998-10-30 1998-12-23 Pharmacia & Upjohn Spa 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents
MXPA02010651A (es) * 2000-04-28 2003-03-10 Sankyo Co Moduladores de receptor activado de proliferador de peroxisoma-gamma.
AU2001257465A1 (en) * 2000-07-14 2002-01-30 Breed Automotive Technology, Inc. Energy absorbing seat belt retractor
CN101125138A (zh) * 2000-12-18 2008-02-20 株式会社医药分子设计研究所 炎症性细胞因子产生游离抑制剂
JP2003064056A (ja) * 2001-08-27 2003-03-05 Sankyo Co Ltd アミド誘導体
WO2003035602A1 (fr) * 2001-10-25 2003-05-01 Sankyo Company, Limited Modulateurs lipidiques
TW200402291A (en) * 2002-06-06 2004-02-16 Inst Med Molecular Design Inc Antiallergic
US6737382B1 (en) * 2002-10-23 2004-05-18 Nippon Soda Co. Ltd. Insecticidal aminothiazole derivatives
US7435823B2 (en) * 2004-01-23 2008-10-14 Amgen Inc. Compounds and methods of use
UA90864C2 (en) * 2004-09-09 2010-06-10 Ромарк Лебораториз, Л.К. Halogenated benzamide derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA021587B1 (ru) * 2009-05-12 2015-07-30 РОМАРК ЛЭБОРЕТЕРИЗ Эл. Си. Соединения галогеналкилгетероарилбензамида

Also Published As

Publication number Publication date
US20080097106A1 (en) 2008-04-24
US7550493B2 (en) 2009-06-23
AU2005285157B2 (en) 2009-07-16
MX2007002969A (es) 2008-02-15
HRP20151439T1 (hr) 2016-02-12
EP1789040A4 (en) 2009-09-02
EP1789040A2 (en) 2007-05-30
CN101035531A (zh) 2007-09-12
IL181849A (en) 2013-11-28
SI1789040T1 (sl) 2016-02-29
AP2007003950A0 (en) 2007-04-30
US7645783B2 (en) 2010-01-12
AP2451A (en) 2012-08-31
IL203061A (en) 2013-04-30
DK1789040T3 (en) 2016-02-01
RS54453B1 (en) 2016-06-30
US7285567B2 (en) 2007-10-23
CA2580347A1 (en) 2006-03-23
WO2006031566A3 (en) 2006-06-08
EP1789040B1 (en) 2015-12-23
KR101344984B1 (ko) 2013-12-24
KR20070052330A (ko) 2007-05-21
HUE026613T2 (hu) 2016-06-28
AU2005285157A1 (en) 2006-03-23
JP4998852B2 (ja) 2012-08-15
ME02370B (me) 2016-06-20
HK1106139A1 (zh) 2008-03-07
BRPI0515089A (pt) 2008-07-08
EA012606B1 (ru) 2009-10-30
CY1118689T1 (el) 2017-07-12
US20080096941A1 (en) 2008-04-24
UA90864C2 (en) 2010-06-10
BRPI0515089B8 (pt) 2021-05-25
US20060089396A1 (en) 2006-04-27
CN101035531B (zh) 2013-01-02
PL1789040T3 (pl) 2016-04-29
IL181849A0 (en) 2007-07-04
JP2008512474A (ja) 2008-04-24
PT1789040E (pt) 2016-02-19
ES2559672T3 (es) 2016-02-15
ZA200702066B (en) 2008-08-27
CA2580347C (en) 2013-12-10
BRPI0515089B1 (pt) 2019-07-16
WO2006031566A2 (en) 2006-03-23

Similar Documents

Publication Publication Date Title
EA200700432A1 (ru) Галогенированные производные бензамида
CY1107008T1 (el) Παραγωγο βενζιμιδαζολης και χρηση ως ανταγωνιστου υποδοχεα aii
NO20072461L (no) Fremstilling og anvendelse av bifenyl-4-yl-karbonylaminosyre derivater for behandling av fedme
EA201000050A1 (ru) Замещенные бициклолактамные соединения
CY1114520T1 (el) Παραγωγο ινδολιζινης και χρηση αυτου για ιατρικους σκοπους
ATE307810T1 (de) Imidazol-2-carbonsäureamid derivate als raf- kinase-inhibitoren
EA200801053A1 (ru) Соединения, пригодные для использования в терапии
IL179607A0 (en) Indoles useful in the treatment of inflammation
RU2011113967A (ru) Новое производное простагландина i2
EA200801596A1 (ru) Новые 11-бета-гидроксиандроста-4-ен-3-оны
WO2004031160A3 (fr) Composes derives de la 2-thiohydantoïne et leur utilisation pour le traitement du diabete
NO20055632L (no) Aromatiske oksyfenyl- og aromatiske sulfanylfenylderivater
BRPI0515628A (pt) composto de 2-morfolina-4-pirimidona
EA200800486A1 (ru) Пестицидные смеси, включающие фенилсемикарбазон
DE60232173D1 (de) Verwendung von sulfonamid-derivaten bei der behandlung von adipositas oder zur verringerung der nahrungsaufnahme
MY158069A (en) Tricyclic compound and pharmaceutical use thereof
NO20074622L (no) Metabolitter for NK-1 antagonister for brekninger
EA200801123A1 (ru) Производные 6-гетероарилпиридоиндолона, способ их получения и применение их в терапии
EA200800149A1 (ru) 4,5-диарилпиррольные производные, способ их получения и применение в терапии
EA200800465A1 (ru) Пестицидные смеси, включающие фенилсемикарбазон
SE0002739D0 (sv) New use
ATE358128T1 (de) Vorbeugende oder therapeutische mittel gegen gastrische oder ösophageale regurgitation
MA32527B1 (fr) Derives 6-heterocyclique -imidazo[1,2-a]pyrroine-2-carboxamides, leur preparation et leur application en therapeutique
EP1908755A4 (en) THERAPEUTIC AGENT AGAINST RESTENOSIS
CY1114798T1 (el) Ενωσεις σουλφοναμιδιου για τη θεραπευτικη αντιμετωπιση αναπνευστικων διαταραχων

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU