AR033753A1 - Derivados de imidazo[1,5-a]pirimido[5,4-d]benzazepina - Google Patents
Derivados de imidazo[1,5-a]pirimido[5,4-d]benzazepinaInfo
- Publication number
- AR033753A1 AR033753A1 ARP020101805A ARP020101805A AR033753A1 AR 033753 A1 AR033753 A1 AR 033753A1 AR P020101805 A ARP020101805 A AR P020101805A AR P020101805 A ARP020101805 A AR P020101805A AR 033753 A1 AR033753 A1 AR 033753A1
- Authority
- AR
- Argentina
- Prior art keywords
- lower alkyl
- cycloalkyl
- substituted
- benzazepina
- pyrimid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Compuestos de fórmula I en donde R1 es halógeno o alquilo inferior; R2 es hidrógeno; alquilo inferior, cicloalquilo -(CH2)m-fenilo, en donde el anillo fenilo puede estar sustituido por alcoxilo inferior, o es -(CH2)m-indolilo; R3 es -C(O)O-alquilo inferior, -C(O)OH, o un grupo heteroaromático de cinco miembros, cuyos anillos pueden estar sustituidos por alquilo inferior o cicloalquilo; n es 0, 1 o 2; m es 0, 1 o 2; y sus sales de adición ácida farmacéuticamente aceptables. Se ha descubierto que esta clase de compuestos muestra una elevada afinidad y selectividad para los sitios de reunión del receptor alfa 5 de GABA A y pueden ser útiles para el tratamiento de mejoras cognitivas o trastornos cognitivos como la enfermedad de Alzheimer.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01112222 | 2001-05-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR033753A1 true AR033753A1 (es) | 2004-01-07 |
Family
ID=8177471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020101805A AR033753A1 (es) | 2001-05-18 | 2002-05-16 | Derivados de imidazo[1,5-a]pirimido[5,4-d]benzazepina |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US6686352B2 (es) |
| EP (1) | EP1399448B1 (es) |
| JP (1) | JP4068466B2 (es) |
| KR (1) | KR100533406B1 (es) |
| CN (1) | CN1230436C (es) |
| AR (1) | AR033753A1 (es) |
| AT (1) | ATE283857T1 (es) |
| AU (1) | AU2002338898B2 (es) |
| BG (1) | BG108369A (es) |
| BR (1) | BR0209859A (es) |
| CA (1) | CA2446903C (es) |
| CZ (1) | CZ20033355A3 (es) |
| DE (1) | DE60202147T2 (es) |
| DK (1) | DK1399448T3 (es) |
| EC (1) | ECSP034851A (es) |
| ES (1) | ES2232778T3 (es) |
| GT (1) | GT200200087A (es) |
| HK (1) | HK1066544A1 (es) |
| HR (1) | HRP20030890A2 (es) |
| HU (1) | HUP0400743A3 (es) |
| IL (2) | IL158572A0 (es) |
| JO (1) | JO2297B1 (es) |
| MA (1) | MA27024A1 (es) |
| MX (1) | MXPA03010529A (es) |
| MY (1) | MY127570A (es) |
| NO (1) | NO20035104L (es) |
| NZ (1) | NZ529097A (es) |
| PA (1) | PA8545201A1 (es) |
| PE (1) | PE20030041A1 (es) |
| PL (1) | PL366846A1 (es) |
| PT (1) | PT1399448E (es) |
| RU (1) | RU2287531C2 (es) |
| SI (1) | SI1399448T1 (es) |
| SK (1) | SK15252003A3 (es) |
| TW (1) | TWI251489B (es) |
| WO (1) | WO2002094834A1 (es) |
| YU (1) | YU90003A (es) |
| ZA (1) | ZA200308544B (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005243175B2 (en) | 2004-05-14 | 2011-12-01 | Millennium Pharmaceuticals, Inc. | Compounds and methods for inhibiting mitotic progression by inhibition of Aurora kinase |
| EP1799684B1 (en) * | 2004-10-04 | 2014-12-03 | Millennium Pharmaceuticals, Inc. | Lactam compounds useful as protein kinase inhibitors |
| MX2007004639A (es) * | 2004-10-20 | 2007-06-08 | Hoffmann La Roche | Derivados de imidazo-benzodiazepina. |
| AU2005299031B2 (en) * | 2004-10-20 | 2011-11-10 | F. Hoffmann-La Roche Ag | Halogen substituted benzodiazepine derivatives |
| BRPI0617204A2 (pt) * | 2005-10-11 | 2011-07-19 | Hoffmann La Roche | derivados de imidazo benzodiazepina |
| PE20080145A1 (es) | 2006-03-21 | 2008-02-11 | Janssen Pharmaceutica Nv | Tetrahidro-pirimidoazepinas como moduladores de trpv1 |
| CL2007003244A1 (es) | 2006-11-16 | 2008-04-04 | Millennium Pharm Inc | Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer. |
| US8288397B2 (en) | 2007-12-17 | 2012-10-16 | Janssen Pharmaceutica Nv | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1 |
| CN101735211B (zh) * | 2008-11-04 | 2012-11-14 | 复旦大学 | 2,3-二氢[1,5]苯并噻氮杂*类化合物或其盐在制备GSK-3β抑制剂中的用途 |
| AR074487A1 (es) | 2008-12-05 | 2011-01-19 | Millennium Pharm Inc | Tiolactamas inhibidoras de proteinquinasas plk, composiciones farmaceuticas que las contienen y usos de las mismas para el tratamiento de trastornos proliferativos e inflamatorios, en particular cancer. |
| CA2747326C (en) | 2008-12-22 | 2017-05-16 | Millennium Pharmaceuticals, Inc. | Combination of aurora kinase inhibitors and anti-cd20 antibodies |
| JO3635B1 (ar) | 2009-05-18 | 2020-08-27 | Millennium Pharm Inc | مركبات صيدلانية صلبة وطرق لانتاجها |
| CN104031049A (zh) | 2010-02-19 | 2014-09-10 | 米伦纽姆医药公司 | 极光激酶抑制剂的结晶形式 |
| CN101891706B (zh) * | 2010-04-09 | 2013-05-29 | 复旦大学 | 3,4-二氢苯并[f][1,4]噻氮杂*类化合物或其盐及其药物用途 |
| CN102424670A (zh) * | 2011-10-31 | 2012-04-25 | 江苏阿尔法药业有限公司 | 一种合成3-(3-氯丙基)-1,3,4,5-四氢-7,8-二甲氧基-2h-3-苯并氮杂卓-2-酮的方法 |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
| US20130303519A1 (en) | 2012-03-20 | 2013-11-14 | Millennium Pharmaceuticals, Inc. | Methods of treating cancer using aurora kinase inhibitors |
| CA2907726A1 (en) | 2013-03-22 | 2014-09-25 | Millennium Pharmaceuticals, Inc. | Combination of catalytic mtorc1/2 inhibitors and selective inhibitors of aurora a kinase |
| US10329301B2 (en) | 2013-12-20 | 2019-06-25 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| MX2017015752A (es) | 2015-06-19 | 2018-04-13 | Agenebio Inc | Derivados de benzodiazepina, composiciones y metodos para tratar deterioro cognitivo. |
| EP3324976A4 (en) | 2015-07-21 | 2019-03-27 | Millennium Pharmaceuticals, Inc. | ADMINISTRATION OF KINASE AURORA INHIBITOR AND CHEMOTHERAPEUTIC AGENTS |
| US11505555B2 (en) | 2016-12-19 | 2022-11-22 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| MX2020013927A (es) | 2018-06-19 | 2021-03-02 | Agenebio Inc | Derivados de benzodiazepina, composiciones y metodos para tratar el deterioro cognitivo. |
| CN110452172B (zh) * | 2019-08-21 | 2021-03-26 | 爱斯特（成都）生物制药股份有限公司 | 一种苯并己内酰胺的合成方法 |
| CN112159411A (zh) * | 2020-10-15 | 2021-01-01 | 南京工业大学 | 一种三氟甲基取代嘧啶并[1,3]二氮杂*化合物及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201311B (es) | 1991-06-17 | 1993-03-01 | Hoffmann La Roche | |
| FR2783828B1 (fr) | 1998-09-29 | 2000-11-10 | Synthelabo | Derives d'acide 5,6-dihydro-4h-imidazo[1,2-a][1] benzazepine -1-acetique, leur preparation et leur application en therapeutique |
| CA2388593A1 (en) | 1999-11-12 | 2001-05-17 | Neurogen Corporation | Bicyclic and tricyclic heteroaromatic compounds |
| TWI239333B (en) | 2000-11-16 | 2005-09-11 | Hoffmann La Roche | Benzodiazepine derivatives as GABA A receptor modulators |
-
2002
- 2002-04-09 US US10/118,584 patent/US6686352B2/en not_active Expired - Fee Related
- 2002-05-08 RU RU2003136078/04A patent/RU2287531C2/ru not_active IP Right Cessation
- 2002-05-08 NZ NZ529097A patent/NZ529097A/en unknown
- 2002-05-08 AT AT02771640T patent/ATE283857T1/de not_active IP Right Cessation
- 2002-05-08 YU YU90003A patent/YU90003A/sh unknown
- 2002-05-08 CN CNB028101774A patent/CN1230436C/zh not_active Expired - Fee Related
- 2002-05-08 CA CA002446903A patent/CA2446903C/en not_active Expired - Fee Related
- 2002-05-08 SK SK1525-2003A patent/SK15252003A3/sk unknown
- 2002-05-08 EP EP02771640A patent/EP1399448B1/en not_active Expired - Lifetime
- 2002-05-08 KR KR10-2003-7015036A patent/KR100533406B1/ko not_active IP Right Cessation
- 2002-05-08 DE DE60202147T patent/DE60202147T2/de not_active Expired - Lifetime
- 2002-05-08 MX MXPA03010529A patent/MXPA03010529A/es active IP Right Grant
- 2002-05-08 PT PT02771640T patent/PT1399448E/pt unknown
- 2002-05-08 CZ CZ20033355A patent/CZ20033355A3/cs unknown
- 2002-05-08 DK DK02771640T patent/DK1399448T3/da active
- 2002-05-08 WO PCT/EP2002/005121 patent/WO2002094834A1/en active IP Right Grant
- 2002-05-08 PL PL02366846A patent/PL366846A1/xx not_active Application Discontinuation
- 2002-05-08 ES ES02771640T patent/ES2232778T3/es not_active Expired - Lifetime
- 2002-05-08 BR BR0209859-8A patent/BR0209859A/pt not_active IP Right Cessation
- 2002-05-08 IL IL15857202A patent/IL158572A0/xx unknown
- 2002-05-08 SI SI200230055T patent/SI1399448T1/xx unknown
- 2002-05-08 HU HU0400743A patent/HUP0400743A3/hu unknown
- 2002-05-08 JP JP2002591507A patent/JP4068466B2/ja not_active Expired - Fee Related
- 2002-05-08 AU AU2002338898A patent/AU2002338898B2/en not_active Ceased
- 2002-05-14 JO JO200243A patent/JO2297B1/en active
- 2002-05-15 PA PA20028545201A patent/PA8545201A1/es unknown
- 2002-05-15 TW TW091110162A patent/TWI251489B/zh not_active IP Right Cessation
- 2002-05-16 AR ARP020101805A patent/AR033753A1/es not_active Application Discontinuation
- 2002-05-16 GT GT200200087A patent/GT200200087A/es unknown
- 2002-05-16 PE PE2002000413A patent/PE20030041A1/es not_active Application Discontinuation
- 2002-05-17 MY MYPI20021808A patent/MY127570A/en unknown
-
2003
- 2003-10-23 IL IL158572A patent/IL158572A/en not_active IP Right Cessation
- 2003-10-31 ZA ZA200308544A patent/ZA200308544B/en unknown
- 2003-11-04 HR HR20030890A patent/HRP20030890A2/xx not_active Application Discontinuation
- 2003-11-14 MA MA27398A patent/MA27024A1/fr unknown
- 2003-11-17 NO NO20035104A patent/NO20035104L/no not_active Application Discontinuation
- 2003-11-17 EC EC2003004851A patent/ECSP034851A/es unknown
- 2003-11-18 BG BG108369A patent/BG108369A/bg unknown
-
2004
- 2004-12-01 HK HK04109492A patent/HK1066544A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR033753A1 (es) | Derivados de imidazo[1,5-a]pirimido[5,4-d]benzazepina | |
| PE20030129A1 (es) | Imidazotriazinas | |
| CR6165A (es) | Procedimientos e intermedios para preparar compuestos anticancerosos | |
| PE10897A1 (es) | Compuestos benzo fusionados | |
| PE20121352A1 (es) | Derivados de heteroarilo que contienen n como inhibidores de cinasa jak3 | |
| RU2007111757A (ru) | Амидные производные 3-фенилдигидропиримидо [4,5-d] пиримидинонов, их получение и использованиев качестве фармацевтических агентов | |
| PE20040832A1 (es) | Derivados de indolil pirazinona | |
| NO20072288L (no) | Sulfonamid pert-substituerte bicykler for okklusly arteriesykdom | |
| UY26872A1 (es) | Derivados de la 4- fenil piridina | |
| PE20051039A1 (es) | [1,8] naftiridin-2-onas y compuestos relacionados | |
| PE20030735A1 (es) | Derivados de benzotiazol | |
| ATE380818T1 (de) | Piperazine-substituierte aryl-benzodiazepinen und ihre verwendung als dopaminrezeptor-antagonisten zur behandlung von psychose | |
| AR043168A1 (es) | Compuestos heterociclicos derivados de oxadiazol, oxazol e isoxazol | |
| AR042002A1 (es) | Benzoxazinonas sustituidas, proceso de obtencion y usos para tratamiento de enfermedades del sistema nervioso central. | |
| PE20061156A1 (es) | Derivados de benzamida como agentes inhibidores del transportador de glicina | |
| AR028475A1 (es) | Derivados de azaindol y uso de los mismos para la manufactura de un medicamento para el tratamiento de la depresion. | |
| AR041481A1 (es) | Derivados de acido arilpropionico-oxazol y su uso como agonistas de ppar | |
| AR041898A1 (es) | Derivados de 4(fenil-piperazinil-metil) benzamida y sus usos para el tratamiento del dolor y desordenes gastrointestinales | |
| AR041376A1 (es) | Piperazinas sustituidas por heterociclos para el tratamiento de la esquizofrenia | |
| AR055005A1 (es) | Imidazo-benzodiazepinas tetraciclicas, procedimiento de obtencion de los mismos medicamentos y su uso de los compuestos para su fabricacion | |
| AR036735A1 (es) | Derivados de 5-metoxi-8-aril-[1,2,4]triazolo[1,5-a]piridina | |
| AR036108A1 (es) | Derivados de oxadiazol, respectivamente de tiadiazol-pirrolidina, uso de dichos derivados en la preparacion de composiciones para modular, bloquear o antagonizar la actividad de oxitocina con sus receptores y/o el tratamiento y/o prevencion de enfermedades mediadas por la oxitocina , inclusive en la | |
| YU18404A (sh) | Hemijska jedinjenja | |
| ES2000524A6 (es) | Procedimiento para la preparacion de nuevas benzamidas y benzoatos sustituidos. | |
| ES2130125T3 (es) | 3-(1-tiazolidinilbutil-4-piperazinil)-1h-indazoles, un procedimiento para su preparacion y su uso como medicamentos. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |