ATE380818T1 - Piperazine-substituierte aryl-benzodiazepinen und ihre verwendung als dopaminrezeptor-antagonisten zur behandlung von psychose - Google Patents
Piperazine-substituierte aryl-benzodiazepinen und ihre verwendung als dopaminrezeptor-antagonisten zur behandlung von psychoseInfo
- Publication number
- ATE380818T1 ATE380818T1 AT03713911T AT03713911T ATE380818T1 AT E380818 T1 ATE380818 T1 AT E380818T1 AT 03713911 T AT03713911 T AT 03713911T AT 03713911 T AT03713911 T AT 03713911T AT E380818 T1 ATE380818 T1 AT E380818T1
- Authority
- AT
- Austria
- Prior art keywords
- sup
- sub
- alkyl
- optionally substituted
- substituted phenyl
- Prior art date
Links
- 208000028017 Psychotic disease Diseases 0.000 title abstract 2
- 229940121891 Dopamine receptor antagonist Drugs 0.000 title 1
- 229940049706 benzodiazepine Drugs 0.000 title 1
- 239000003210 dopamine receptor blocking agent Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 208000020925 Bipolar disease Diseases 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000013078 crystal Chemical group 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- -1 methoxy, ethoxy Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
- 239000012453 solvate Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/38—[b, e]- or [b, f]-condensed with six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36867002P | 2002-03-28 | 2002-03-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE380818T1 true ATE380818T1 (de) | 2007-12-15 |
Family
ID=28675525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03713911T ATE380818T1 (de) | 2002-03-28 | 2003-03-17 | Piperazine-substituierte aryl-benzodiazepinen und ihre verwendung als dopaminrezeptor-antagonisten zur behandlung von psychose |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7214673B2 (de) |
| EP (1) | EP1492794B1 (de) |
| JP (1) | JP2005533009A (de) |
| AT (1) | ATE380818T1 (de) |
| AU (1) | AU2003217936A1 (de) |
| CA (1) | CA2479932A1 (de) |
| DE (1) | DE60318030T2 (de) |
| ES (1) | ES2297142T3 (de) |
| WO (1) | WO2003082877A1 (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004014895A1 (en) * | 2002-08-05 | 2004-02-19 | Eli Lilly And Company | Piperazine substituted aryl benzodiazepines |
| JP2007505106A (ja) * | 2003-09-09 | 2007-03-08 | イーライ リリー アンド カンパニー | アゼピン、オキサゼピン、およびチアゼピンの置換ピペラジン |
| PT1696931E (pt) | 2003-12-22 | 2009-06-12 | Acadia Pharm Inc | Análogos diaril[a,d]ciclo-hepteno substituídos com amino utilizados como agonistas muscarínicos e métodos de tratamento de perturbações neuropsiquiátricas |
| CA2550679A1 (en) * | 2003-12-23 | 2005-07-14 | Schering Corporation | Substituted n-aryl amidines as selective d1 dopamine receptor antagonists for the treatment of obesity and cns disorders |
| CN103214473A (zh) | 2007-03-15 | 2013-07-24 | ARYx医疗有限公司 | 二苯并[b,f][1,4]氧杂氮杂*化合物 |
| US20110172262A1 (en) | 2008-09-15 | 2011-07-14 | Biovista, Inc. | Compositions and methods for treating epilepsy |
| EP2344453B1 (de) | 2008-10-09 | 2016-12-28 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Aktivatoren der humanen pyruvatkinase |
| EP2395986A1 (de) * | 2009-02-10 | 2011-12-21 | Abbott Laboratories | Verfahren für die herstellung von s1p-rezeptoragonisten und -antagonisten |
| JP2013525438A (ja) | 2010-04-29 | 2013-06-20 | アメリカ合衆国 | ヒトピルビン酸キナーゼ活性剤 |
| PL395468A1 (pl) * | 2011-06-29 | 2013-01-07 | Adamed Spólka Z Ograniczona Odpowiedzialnoscia | Zwiazki amidoalkilopiperazynylowe do leczenia chorób osrodkowego ukladu nerwowego |
| US20150018362A1 (en) | 2012-02-27 | 2015-01-15 | Biovista, Inc. | Compositions and methods for treating mitochondrial diseases |
| US20140057303A1 (en) | 2012-08-21 | 2014-02-27 | Janssen Pharmaceutica Nv | Antibodies to Olanzapine Haptens and Use Thereof |
| WO2014031600A1 (en) | 2012-08-21 | 2014-02-27 | Janssen Pharmaceutica Nv | Haptens of quetiapine for use in immunoassays |
| JP2015527365A (ja) | 2012-08-21 | 2015-09-17 | オルソ−クリニカル ダイアグノスティクス，インコーポレイティド | パリペリドンに対する抗体及びその使用 |
| CN110054693A (zh) | 2012-08-21 | 2019-07-26 | 詹森药业有限公司 | 喹硫平半抗原的抗体及其用途 |
| CN104854110B (zh) * | 2012-08-21 | 2016-12-28 | 詹森药业有限公司 | 奥氮平半抗原 |
| CN108484496B (zh) | 2012-08-21 | 2022-03-22 | 詹森药业有限公司 | 阿立哌唑半抗原及其在免疫测定中的应用 |
| PT2888258T (pt) | 2012-08-21 | 2019-08-21 | Janssen Pharmaceutica Nv | Hapteno de paliperidona |
| US9012648B2 (en) | 2012-08-21 | 2015-04-21 | Janssen Pharmaceutica Nv | Haptens of risperidone and paliperidone |
| PL3333195T3 (pl) | 2012-08-21 | 2021-02-22 | Janssen Pharmaceutica Nv | Przeciwciała względem kwetiapiny i ich zastosowania |
| EP2888284B1 (de) | 2012-08-21 | 2022-07-06 | Janssen Pharmaceutica NV | Antikörper gegen risperidon-haptene und verwendungen davon |
| JP6216926B2 (ja) | 2012-08-21 | 2017-10-25 | ヤンセン ファーマシューティカ エヌ．ベー． | オランザピンに対する抗体及びその使用 |
| US20140057297A1 (en) | 2012-08-21 | 2014-02-27 | Janssen Pharmaceutica Nv | Antibodies to Paliperidone Haptens and Use Thereof |
| CA2882594C (en) | 2012-08-21 | 2019-07-16 | Ortho-Clinical Diagnostics, Inc. | Antibodies to risperidone and use thereof |
| CN107325183B (zh) | 2012-08-21 | 2021-06-04 | 詹森药业有限公司 | 阿立哌唑的抗体及其用途 |
| AU2013305970B2 (en) | 2012-08-21 | 2017-08-17 | Saladax Biomedical Inc. | Antibodies to aripiprazole haptens and use thereof |
| WO2014078568A1 (en) | 2012-11-14 | 2014-05-22 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| AU2014386720B2 (en) | 2014-06-20 | 2016-07-21 | Suntory Holdings Limited | Uric acid-lowering agent |
| CN104370833A (zh) * | 2014-10-26 | 2015-02-25 | 湖南华腾制药有限公司 | 一种1,4-二取代三唑衍生物的制备方法 |
| JP6949025B2 (ja) | 2015-12-17 | 2021-10-13 | ヤンセン ファーマシューティカ エヌ．ベー． | リスペリドンに対する抗体及びその使用 |
| US10435478B2 (en) | 2015-12-17 | 2019-10-08 | Janssen Pharmaceutica Nv | Antibodies to quetiapine and use thereof |
| CN110452183B (zh) * | 2019-09-04 | 2023-03-14 | 中国科学院上海有机化学研究所 | 一种手性杂环化合物的制备方法 |
| CN114671829B (zh) * | 2022-04-22 | 2023-07-25 | 合肥工业大学 | 以茚酮和二苯并氮杂卓为母核的杂二联体及其盐酸盐、其制备方法和用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3457264A (en) * | 1965-07-06 | 1969-07-22 | Farmochimica Cutolo Calosi Spa | N-(5h-dibenzo-(a,d)-cyclohepten - 5 - one-11-yl)-piperazines and method of preparing the same |
| US4087421A (en) | 1976-04-19 | 1978-05-02 | American Cyanamid Company | Substituted benzodiazepines and method of use |
| US4431589A (en) | 1980-12-11 | 1984-02-14 | Lilly House | Benzodiazepine compounds and their use as pharmaceuticals |
| US4987421A (en) * | 1988-06-09 | 1991-01-22 | Mitsubishi Denki Kabushiki Kaisha | Microstrip antenna |
| GB8819059D0 (en) | 1988-08-11 | 1988-09-14 | Lilly Industries Ltd | Benzodiazepine compounds & their use as pharmaceuticals |
| US5602124A (en) | 1994-12-12 | 1997-02-11 | Allelix Biopharmaceuticals, Inc. | 5-HT2 receptor ligands |
-
2003
- 2003-03-17 DE DE60318030T patent/DE60318030T2/de not_active Expired - Fee Related
- 2003-03-17 WO PCT/US2003/006708 patent/WO2003082877A1/en active IP Right Grant
- 2003-03-17 AU AU2003217936A patent/AU2003217936A1/en not_active Abandoned
- 2003-03-17 CA CA002479932A patent/CA2479932A1/en not_active Abandoned
- 2003-03-17 AT AT03713911T patent/ATE380818T1/de not_active IP Right Cessation
- 2003-03-17 JP JP2003580342A patent/JP2005533009A/ja not_active Withdrawn
- 2003-03-17 US US10/505,805 patent/US7214673B2/en not_active Expired - Fee Related
- 2003-03-17 ES ES03713911T patent/ES2297142T3/es not_active Expired - Lifetime
- 2003-03-17 EP EP03713911A patent/EP1492794B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20050203296A1 (en) | 2005-09-15 |
| US7214673B2 (en) | 2007-05-08 |
| DE60318030T2 (de) | 2008-04-10 |
| CA2479932A1 (en) | 2003-10-09 |
| WO2003082877A1 (en) | 2003-10-09 |
| JP2005533009A (ja) | 2005-11-04 |
| EP1492794B1 (de) | 2007-12-12 |
| EP1492794A1 (de) | 2005-01-05 |
| DE60318030D1 (de) | 2008-01-24 |
| AU2003217936A1 (en) | 2003-10-13 |
| ES2297142T3 (es) | 2008-05-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |