SI1399448T1 - Imidazo 1,5-a) pyrimido 5,4-d) benzazepine derivatives as gaba a receptor modulators - Google Patents

Imidazo 1,5-a) pyrimido 5,4-d) benzazepine derivatives as gaba a receptor modulators

Info

Publication number: SI1399448T1
Authority: SI; Slovenia
Prior art keywords: pyrimido; gaba; imidazo; receptor modulators; benzazepine derivatives
Prior art date: 2001-05-18

Application number

SI200230055T

Other languages

English (en)

Slovenian (sl)

Inventor

Raffaello Masciadri

Andrew William Thomas

Juergen Wichmann

Original Assignee

F. Hoffmann-La Roche Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-05-18

Filing date

2002-05-08

Publication date

2005-02-28

2002-05-08 Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag

2005-02-28 Publication of SI1399448T1 publication Critical patent/SI1399448T1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

SI200230055T 2001-05-18 2002-05-08 Imidazo 1,5-a) pyrimido 5,4-d) benzazepine derivatives as gaba a receptor modulators SI1399448T1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP01112222		2001-05-18
PCT/EP2002/005121 WO2002094834A1 (en)	2001-05-18	2002-05-08	Imidazo [1,5-a] pyrimido [5,4-d] benzazepine derivatives as gaba a receptor modulators
EP02771640A EP1399448B1 (en)	2001-05-18	2002-05-08	Imidazo 1,5-a] pyrimido 5,4-d] benzazepine derivatives as gaba a receptor modulators

Publications (1)

Publication Number	Publication Date
SI1399448T1 true SI1399448T1 (en)	2005-02-28

Family

ID=8177471

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI200230055T SI1399448T1 (en)	2001-05-18	2002-05-08	Imidazo 1,5-a) pyrimido 5,4-d) benzazepine derivatives as gaba a receptor modulators

Country Status (38)

Country	Link
US (1)	US6686352B2 (es)
EP (1)	EP1399448B1 (es)
JP (1)	JP4068466B2 (es)
KR (1)	KR100533406B1 (es)
CN (1)	CN1230436C (es)
AR (1)	AR033753A1 (es)
AT (1)	ATE283857T1 (es)
AU (1)	AU2002338898B2 (es)
BG (1)	BG108369A (es)
BR (1)	BR0209859A (es)
CA (1)	CA2446903C (es)
CZ (1)	CZ20033355A3 (es)
DE (1)	DE60202147T2 (es)
DK (1)	DK1399448T3 (es)
EC (1)	ECSP034851A (es)
ES (1)	ES2232778T3 (es)
GT (1)	GT200200087A (es)
HK (1)	HK1066544A1 (es)
HR (1)	HRP20030890A2 (es)
HU (1)	HUP0400743A3 (es)
IL (2)	IL158572A0 (es)
JO (1)	JO2297B1 (es)
MA (1)	MA27024A1 (es)
MX (1)	MXPA03010529A (es)
MY (1)	MY127570A (es)
NO (1)	NO20035104L (es)
NZ (1)	NZ529097A (es)
PA (1)	PA8545201A1 (es)
PE (1)	PE20030041A1 (es)
PL (1)	PL366846A1 (es)
PT (1)	PT1399448E (es)
RU (1)	RU2287531C2 (es)
SI (1)	SI1399448T1 (es)
SK (1)	SK15252003A3 (es)
TW (1)	TWI251489B (es)
WO (1)	WO2002094834A1 (es)
YU (1)	YU90003A (es)
ZA (1)	ZA200308544B (es)

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KR20120091275A (ko)	2004-05-14	2012-08-17	밀레니엄 파머슈티컬스 인코퍼레이티드	아우로라 키나아제의 억제에 의해 유사분열 진행을 억제하기 위한 화합물 및 그 방법
EP1799684B1 (en) *	2004-10-04	2014-12-03	Millennium Pharmaceuticals, Inc.	Lactam compounds useful as protein kinase inhibitors
MX2007004640A (es) *	2004-10-20	2007-06-08	Hoffmann La Roche	Derivados de benzodiazepina sustituidos con halogeno.
MX2007004639A (es) *	2004-10-20	2007-06-08	Hoffmann La Roche	Derivados de imidazo-benzodiazepina.
AU2006301377B2 (en) *	2005-10-11	2012-03-08	F. Hoffmann-La Roche Ag	Imidazo benzodiazepine derivatives
PE20080145A1 (es) *	2006-03-21	2008-02-11	Janssen Pharmaceutica Nv	Tetrahidro-pirimidoazepinas como moduladores de trpv1
CL2007003244A1 (es)	2006-11-16	2008-04-04	Millennium Pharm Inc	Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
CL2008003749A1 (es)	2007-12-17	2010-01-15	Janssen Pharmaceutica Nv	Compuestos derivados de imidazol, oxazol, y tiazol pirimidina, moduladores de trpv1, proceso de preparacion, composicion farmaceutica y su uso en el tratamiento de enfermedades, trastornos o condicion de dolor, prurito, artritis, tos, asma, trastorno del oido interno y enfermedad inflamatoria intestinal, entre otras.
CN101735211B (zh) *	2008-11-04	2012-11-14	复旦大学	2,3-二氢[1,5]苯并噻氮杂*类化合物或其盐在制备GSK-3β抑制剂中的用途
JP5684719B2 (ja) *	2008-12-05	2015-03-18	ミレニアムファーマシューティカルズ，インコーポレイテッドＭｉｌｌｅｎｎｉｕｍＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ．	Ｐｌｋ阻害剤としての５，７−ジヒドロ−６ｈ−ピリミド［５、−４ｄ］［１］ベンゾアゼピン−６−チオン
EP2376082B1 (en)	2008-12-22	2014-03-05	Millennium Pharmaceuticals, Inc.	Combination of aurora kinase inhibitors and anti-cd20 antibodies
JO3635B1 (ar)	2009-05-18	2020-08-27	Millennium Pharm Inc	مركبات صيدلانية صلبة وطرق لانتاجها
JP2013520424A (ja)	2010-02-19	2013-06-06	ミレニアムファーマシューティカルズ，インコーポレイテッド	ナトリウム４−｛［９−クロロ−７−（２−フルオロ−６−メトキシフェニル）−５Ｈ−ピリミド［５，４−ｄ］［２］ベンゾアゼピン−２−イル］アミノ｝−２−メトキシベンゾエートの結晶形
CN101891706B (zh) *	2010-04-09	2013-05-29	复旦大学	3,4-二氢苯并[f][1,4]噻氮杂*类化合物或其盐及其药物用途
CN102424670A (zh) *	2011-10-31	2012-04-25	江苏阿尔法药业有限公司	一种合成3-(3-氯丙基)-1,3,4,5-四氢-7,8-二甲氧基-2h-3-苯并氮杂卓-2-酮的方法
US20150374705A1 (en)	2012-02-14	2015-12-31	Shanghai Institues for Biological Sciences	Substances for treatment or relief of pain
US20130303519A1 (en)	2012-03-20	2013-11-14	Millennium Pharmaceuticals, Inc.	Methods of treating cancer using aurora kinase inhibitors
CN105209042B (zh)	2013-03-22	2019-03-08	米伦纽姆医药公司	催化性mtorc 1/2抑制剂与选择性极光a激酶抑制剂的组合
AU2014368961B2 (en)	2013-12-20	2019-10-17	Agenebio, Inc.	Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
WO2016205739A1 (en)	2015-06-19	2016-12-22	Belew Mekonnen	Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
EP3324976A4 (en)	2015-07-21	2019-03-27	Millennium Pharmaceuticals, Inc.	ADMINISTRATION OF KINASE AURORA INHIBITOR AND CHEMOTHERAPEUTIC AGENTS
US11505555B2 (en)	2016-12-19	2022-11-22	Agenebio, Inc.	Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
WO2019246300A1 (en)	2018-06-19	2019-12-26	Agenebio, Inc.	Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CN110452172B (zh) *	2019-08-21	2021-03-26	爱斯特（成都）生物制药股份有限公司	一种苯并己内酰胺的合成方法
CN112159411A (zh) *	2020-10-15	2021-01-01	南京工业大学	一种三氟甲基取代嘧啶并[1,3]二氮杂*化合物及其制备方法

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TW201311B (es)	1991-06-17	1993-03-01	Hoffmann La Roche
FR2783828B1 (fr)	1998-09-29	2000-11-10	Synthelabo	Derives d'acide 5,6-dihydro-4h-imidazo[1,2-a][1] benzazepine -1-acetique, leur preparation et leur application en therapeutique
US6511987B1 (en)	1999-11-12	2003-01-28	Neurogen Corporation	Bicyclic and tricyclic heteroaromatic compounds
TWI239333B (en)	2000-11-16	2005-09-11	Hoffmann La Roche	Benzodiazepine derivatives as GABA A receptor modulators

2002
- 2002-04-09 US US10/118,584 patent/US6686352B2/en not_active Expired - Fee Related
- 2002-05-08 NZ NZ529097A patent/NZ529097A/en unknown
- 2002-05-08 BR BR0209859-8A patent/BR0209859A/pt not_active IP Right Cessation
- 2002-05-08 ES ES02771640T patent/ES2232778T3/es not_active Expired - Lifetime
- 2002-05-08 DK DK02771640T patent/DK1399448T3/da active
- 2002-05-08 AU AU2002338898A patent/AU2002338898B2/en not_active Ceased
- 2002-05-08 CZ CZ20033355A patent/CZ20033355A3/cs unknown
- 2002-05-08 EP EP02771640A patent/EP1399448B1/en not_active Expired - Lifetime
- 2002-05-08 AT AT02771640T patent/ATE283857T1/de not_active IP Right Cessation
- 2002-05-08 CN CNB028101774A patent/CN1230436C/zh not_active Expired - Fee Related
- 2002-05-08 KR KR10-2003-7015036A patent/KR100533406B1/ko not_active IP Right Cessation
- 2002-05-08 DE DE60202147T patent/DE60202147T2/de not_active Expired - Lifetime
- 2002-05-08 SK SK1525-2003A patent/SK15252003A3/sk unknown
- 2002-05-08 JP JP2002591507A patent/JP4068466B2/ja not_active Expired - Fee Related
- 2002-05-08 IL IL15857202A patent/IL158572A0/xx unknown
- 2002-05-08 SI SI200230055T patent/SI1399448T1/xx unknown
- 2002-05-08 PT PT02771640T patent/PT1399448E/pt unknown
- 2002-05-08 YU YU90003A patent/YU90003A/sh unknown
- 2002-05-08 RU RU2003136078/04A patent/RU2287531C2/ru not_active IP Right Cessation
- 2002-05-08 MX MXPA03010529A patent/MXPA03010529A/es active IP Right Grant
- 2002-05-08 CA CA002446903A patent/CA2446903C/en not_active Expired - Fee Related
- 2002-05-08 WO PCT/EP2002/005121 patent/WO2002094834A1/en active IP Right Grant
- 2002-05-08 HU HU0400743A patent/HUP0400743A3/hu unknown
- 2002-05-08 PL PL02366846A patent/PL366846A1/xx not_active Application Discontinuation
- 2002-05-14 JO JO200243A patent/JO2297B1/en active
- 2002-05-15 PA PA20028545201A patent/PA8545201A1/es unknown
- 2002-05-15 TW TW091110162A patent/TWI251489B/zh not_active IP Right Cessation
- 2002-05-16 AR ARP020101805A patent/AR033753A1/es not_active Application Discontinuation
- 2002-05-16 GT GT200200087A patent/GT200200087A/es unknown
- 2002-05-16 PE PE2002000413A patent/PE20030041A1/es not_active Application Discontinuation
- 2002-05-17 MY MYPI20021808A patent/MY127570A/en unknown
2003
- 2003-10-23 IL IL158572A patent/IL158572A/en not_active IP Right Cessation
- 2003-10-31 ZA ZA200308544A patent/ZA200308544B/en unknown
- 2003-11-04 HR HR20030890A patent/HRP20030890A2/xx not_active Application Discontinuation
- 2003-11-14 MA MA27398A patent/MA27024A1/fr unknown
- 2003-11-17 NO NO20035104A patent/NO20035104L/no not_active Application Discontinuation
- 2003-11-17 EC EC2003004851A patent/ECSP034851A/es unknown
- 2003-11-18 BG BG108369A patent/BG108369A/bg unknown
2004
- 2004-12-01 HK HK04109492A patent/HK1066544A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
ZA200308544B (en)	2005-01-31
JP2004531563A (ja)	2004-10-14
ES2232778T3 (es)	2005-06-01
NO20035104D0 (no)	2003-11-17
SK15252003A3 (sk)	2004-08-03
CN1230436C (zh)	2005-12-07
PE20030041A1 (es)	2003-02-07
MY127570A (en)	2006-12-29
EP1399448A1 (en)	2004-03-24
AU2002338898B8 (en)	2002-12-03
US20030055042A1 (en)	2003-03-20
IL158572A0 (en)	2004-05-12
PT1399448E (pt)	2005-03-31
PL366846A1 (en)	2005-02-07
CZ20033355A3 (en)	2004-07-14
ATE283857T1 (de)	2004-12-15
HK1066544A1 (en)	2005-03-24
HUP0400743A2 (hu)	2004-07-28
DK1399448T3 (da)	2005-04-11
BR0209859A (pt)	2004-06-15
RU2003136078A (ru)	2005-05-27
US6686352B2 (en)	2004-02-03
IL158572A (en)	2010-02-17
KR100533406B1 (ko)	2005-12-02
GT200200087A (es)	2003-06-19
CA2446903A1 (en)	2002-11-28
JP4068466B2 (ja)	2008-03-26
RU2287531C2 (ru)	2006-11-20
AR033753A1 (es)	2004-01-07
HUP0400743A3 (en)	2007-09-28
MA27024A1 (fr)	2004-12-20
JO2297B1 (en)	2005-09-12
PA8545201A1 (es)	2003-02-28
DE60202147D1 (de)	2005-01-05
HRP20030890A2 (en)	2005-08-31
WO2002094834A1 (en)	2002-11-28
DE60202147T2 (de)	2005-12-01
TWI251489B (en)	2006-03-21
AU2002338898B2 (en)	2007-03-15
BG108369A (bg)	2005-01-31
YU90003A (sh)	2006-08-17
CA2446903C (en)	2008-12-30
ECSP034851A (es)	2003-12-24
MXPA03010529A (es)	2004-03-02
NZ529097A (en)	2005-04-29
NO20035104L (no)	2003-11-17
KR20040002975A (ko)	2004-01-07
EP1399448B1 (en)	2004-12-01
CN1509289A (zh)	2004-06-30

Publication	Publication Date	Title
SI1399448T1 (en)	2005-02-28	Imidazo 1,5-a) pyrimido 5,4-d) benzazepine derivatives as gaba a receptor modulators
TWI346664B (en)	2011-08-11	Substituted 8'-pyri(mi)dinyl-dihydrospiro-[cycloalkylamine]-pyrimido[1,2-a] pyrimidin-6-one derivatives
PL370535A1 (en)	2005-05-30	Substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyrimidinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1h)one derivatives for neurodegenerative disorders
DK1686130T3 (da)	2009-04-06	Pyrrolo-[2,3-d]-pyrimidinforbindelser som immunsuppressive midler
EG24399A (en)	2009-04-29	Pyrrolo[2,3-D]pyrimidine compounds
EP1599482A4 (en)	2008-10-01	PYRAZOLO1,5-A PYRIMIDINE DERIVATIVES
EP1653969A4 (en)	2006-12-20	PYRROLO 1,2-B PYRIDAZINE DERIVATIVES
SI1220856T1 (en)	2005-06-30	Pyrazolo(4,3-d)pyrimidine derivatives
HUP0301614A3 (en)	2005-02-28	Pyrido[2,3-d]pyrimidini and pyrimido[4,5-d]pyrimidini nucleosides
IL170680A0 (en)	2009-02-11	8 - SUBSTITUTED - 6,7,8,9 -TETRAHYDROPYRIMIDO [1,2-a] PYRIMIDIN - 4 - ONE DERIVATIVES
ZA200507192B (en)	2007-03-28	Substituted 8-perfluoroalkyl-6,7,8,9-tetrahydropyrimido [1,2-A] pyrimidin-4-one derivatives
PT1674456E (pt)	2008-09-11	Utilização de 2-fluoro-3-cetoésteres para preparar 3-fluoro- 6,7,8,9-tetra-hidro-4-h-pirimido[1,2-a]pirimidin-4-onas
AU1224902A (en)	2002-03-13	2-pyridinyl-6,7,8,9-tetrahydropyrimido(1,2-a)pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo(1,2-a)pyrimidin-5(1H)one derivatives
IL156536A0 (en)	2004-01-04	Pyrazolo [3,4-d] pyrimidin-4-one derivatives and pharmaceutical compositions containing the same
PL353366A1 (en)	2003-11-17	Pyrazolo[4,3-d]pyrimidines
PL370067A1 (en)	2005-05-16	8-amino-[1,2,4]triazolo[1,5-a]pyridine-6-carboxylic acid amide
PL356668A1 (en)	2004-06-28	Novel substituted pyrazolo[4,3-e
HUP0401991A3 (en)	2005-11-28	Method for producing of substituted imidazo[1,2-a]-5,6,7,8-tetrahydropyridine-8-on derivatives
AU2002226861A1 (en)	2002-08-12	Novel forms of 2,3-dimethyl-8-(2-ethyl-6-methylbenzylamino)-imidazo (1,2-a)pyridine-6-carboxamide
AU2002228540A1 (en)	2002-08-12	Novel forms of 2,3-dimethyl-8-(2-ethyl-6-methylbenzylamino)-imidazo (1,2-a)pyridine-6-carboxamide
AU2002228541A1 (en)	2002-08-12	Novel forms of 2,3-dimethyl-8-(2-ethyl-6-methylbenzylamino)-imidazo (1,2-a)pyridine-6-carboxamide
SI1210349T1 (en)	2003-06-30	PYRAZOLO 4,3-d)PYRIMIDINES
GB0110251D0 (en)	2001-06-20	Process for the preparation of pyrazolo[4,4-d]Pyrimidin-7-one compounds and intermediates thereof