DE60202147D1 - Imidazo(1,5-a!pyrimido)5,4-d!benz azepinderivate als gaba-a-rezeptormodulatoren - Google Patents

Imidazo(1,5-a!pyrimido)5,4-d!benz azepinderivate als gaba-a-rezeptormodulatoren

Info

Publication number: DE60202147D1
Authority: DE; Germany
Prior art keywords: pyrimido; gaba; imidazo; receptor modulators; azepine derivatives
Prior art date: 2001-05-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60202147T

Other languages

English (en)

Other versions

DE60202147T2 (de

Inventor

Raffaello Masciadri

William Thomas

Juergen Wichmann

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

HOFFMANN LA ROCHE

F Hoffmann La Roche AG

Original Assignee

HOFFMANN LA ROCHE

F Hoffmann La Roche AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-05-18

Filing date

2002-05-08

Publication date

2005-01-05

2002-05-08 Application filed by HOFFMANN LA ROCHE, F Hoffmann La Roche AG filed Critical HOFFMANN LA ROCHE

2005-01-05 Publication of DE60202147D1 publication Critical patent/DE60202147D1/de

2005-12-01 Application granted granted Critical

2005-12-01 Publication of DE60202147T2 publication Critical patent/DE60202147T2/de

2022-05-09 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DE60202147T 2001-05-18 2002-05-08 Imidazo(1,5-a)pyrimido(5,4-d)(1)benzazepinderivate als GABA-A-Rezeptormodulatoren Expired - Lifetime DE60202147T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP01112222		2001-05-18
EP01112222		2001-05-18
PCT/EP2002/005121 WO2002094834A1 (en)	2001-05-18	2002-05-08	Imidazo [1,5-a] pyrimido [5,4-d] benzazepine derivatives as gaba a receptor modulators

Publications (2)

Publication Number	Publication Date
DE60202147D1 true DE60202147D1 (de)	2005-01-05
DE60202147T2 DE60202147T2 (de)	2005-12-01

Family

ID=8177471

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60202147T Expired - Lifetime DE60202147T2 (de)	2001-05-18	2002-05-08	Imidazo(1,5-a)pyrimido(5,4-d)(1)benzazepinderivate als GABA-A-Rezeptormodulatoren

Country Status (38)

Country	Link
US (1)	US6686352B2 (de)
EP (1)	EP1399448B1 (de)
JP (1)	JP4068466B2 (de)
KR (1)	KR100533406B1 (de)
CN (1)	CN1230436C (de)
AR (1)	AR033753A1 (de)
AT (1)	ATE283857T1 (de)
AU (1)	AU2002338898B2 (de)
BG (1)	BG108369A (de)
BR (1)	BR0209859A (de)
CA (1)	CA2446903C (de)
CZ (1)	CZ20033355A3 (de)
DE (1)	DE60202147T2 (de)
DK (1)	DK1399448T3 (de)
EC (1)	ECSP034851A (de)
ES (1)	ES2232778T3 (de)
GT (1)	GT200200087A (de)
HK (1)	HK1066544A1 (de)
HR (1)	HRP20030890A2 (de)
HU (1)	HUP0400743A3 (de)
IL (2)	IL158572A0 (de)
JO (1)	JO2297B1 (de)
MA (1)	MA27024A1 (de)
MX (1)	MXPA03010529A (de)
MY (1)	MY127570A (de)
NO (1)	NO20035104L (de)
NZ (1)	NZ529097A (de)
PA (1)	PA8545201A1 (de)
PE (1)	PE20030041A1 (de)
PL (1)	PL366846A1 (de)
PT (1)	PT1399448E (de)
RU (1)	RU2287531C2 (de)
SI (1)	SI1399448T1 (de)
SK (1)	SK15252003A3 (de)
TW (1)	TWI251489B (de)
WO (1)	WO2002094834A1 (de)
YU (1)	YU90003A (de)
ZA (1)	ZA200308544B (de)

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KR101748290B1 (ko)	2004-05-14	2017-06-16	밀레니엄 파머슈티컬스 인코퍼레이티드	아우로라 키나아제의 억제에 의해 유사분열 진행을 억제하기 위한 화합물 및 그 방법
CN101068815B (zh) *	2004-10-04	2012-09-05	千禧药品公司	有效作为蛋白激酶抑制剂的内酰胺化合物
KR100915469B1 (ko) *	2004-10-20	2009-09-03	에프. 호프만-라 로슈 아게	할로겐 치환된 벤조다이아제핀 유도체
NZ554439A (en) *	2004-10-20	2009-09-25	Hoffmann La Roche	Imidazo-benzodiazepine derivatives
CA2625611A1 (en) *	2005-10-11	2007-04-19	F. Hoffman-La Roche Ag	Imidazo benzodiazepine derivatives
PE20080145A1 (es)	2006-03-21	2008-02-11	Janssen Pharmaceutica Nv	Tetrahidro-pirimidoazepinas como moduladores de trpv1
CL2007003244A1 (es)	2006-11-16	2008-04-04	Millennium Pharm Inc	Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
CL2008003749A1 (es)	2007-12-17	2010-01-15	Janssen Pharmaceutica Nv	Compuestos derivados de imidazol, oxazol, y tiazol pirimidina, moduladores de trpv1, proceso de preparacion, composicion farmaceutica y su uso en el tratamiento de enfermedades, trastornos o condicion de dolor, prurito, artritis, tos, asma, trastorno del oido interno y enfermedad inflamatoria intestinal, entre otras.
CN101735211B (zh) *	2008-11-04	2012-11-14	复旦大学	2,3-二氢[1,5]苯并噻氮杂*类化合物或其盐在制备GSK-3β抑制剂中的用途
AR074487A1 (es)	2008-12-05	2011-01-19	Millennium Pharm Inc	Tiolactamas inhibidoras de proteinquinasas plk, composiciones farmaceuticas que las contienen y usos de las mismas para el tratamiento de trastornos proliferativos e inflamatorios, en particular cancer.
EP2376082B1 (de)	2008-12-22	2014-03-05	Millennium Pharmaceuticals, Inc.	Kombination von aurora-kinase-inhibitoren und anti-cd20-antikörpern
JO3635B1 (ar)	2009-05-18	2020-08-27	Millennium Pharm Inc	مركبات صيدلانية صلبة وطرق لانتاجها
WO2011103089A1 (en)	2010-02-19	2011-08-25	Millennium Pharmaceuticals, Inc.	Crystalline forms of sodium 4-{[9-chloro-7-(2-fluoro-6--methoxyphenyl)-5h -pyrimido[5,4-d][2]benzazepin-2yl]amino}-2-methoxybenzoate
CN101891706B (zh) *	2010-04-09	2013-05-29	复旦大学	3,4-二氢苯并[f][1,4]噻氮杂*类化合物或其盐及其药物用途
CN102424670A (zh) *	2011-10-31	2012-04-25	江苏阿尔法药业有限公司	一种合成3-(3-氯丙基)-1,3,4,5-四氢-7,8-二甲氧基-2h-3-苯并氮杂卓-2-酮的方法
US20150374705A1 (en)	2012-02-14	2015-12-31	Shanghai Institues for Biological Sciences	Substances for treatment or relief of pain
US20130303519A1 (en)	2012-03-20	2013-11-14	Millennium Pharmaceuticals, Inc.	Methods of treating cancer using aurora kinase inhibitors
CN105209042B (zh)	2013-03-22	2019-03-08	米伦纽姆医药公司	催化性mtorc 1/2抑制剂与选择性极光a激酶抑制剂的组合
CN106068256B (zh)	2013-12-20	2020-10-23	艾吉因生物股份有限公司	用于治疗认知损害的苯并二氮杂*衍生物、组合物和方法
IL256354B (en)	2015-06-19	2022-09-01	Agenebio Inc	Benzodiazepine derivatives, compositions, and uses thereof for treating cognitive impairment
US20180207173A1 (en)	2015-07-21	2018-07-26	Millennium Pharmaceuticals, Inc.	Administration of aurora kinase inhibitor and chemotherapeutic agents
US11505555B2 (en)	2016-12-19	2022-11-22	Agenebio, Inc.	Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
MX2020013927A (es)	2018-06-19	2021-03-02	Agenebio Inc	Derivados de benzodiazepina, composiciones y metodos para tratar el deterioro cognitivo.
CN110452172B (zh) *	2019-08-21	2021-03-26	爱斯特（成都）生物制药股份有限公司	一种苯并己内酰胺的合成方法
CN112159411A (zh) *	2020-10-15	2021-01-01	南京工业大学	一种三氟甲基取代嘧啶并[1,3]二氮杂*化合物及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW201311B (de)	1991-06-17	1993-03-01	Hoffmann La Roche
FR2783828B1 (fr)	1998-09-29	2000-11-10	Synthelabo	Derives d'acide 5,6-dihydro-4h-imidazo[1,2-a][1] benzazepine -1-acetique, leur preparation et leur application en therapeutique
ES2195943T3 (es)	1999-11-12	2003-12-16	Neurogen Corp	Compuestos heteroaromaticos biciclicos y triciclicos.
TWI239333B (en)	2000-11-16	2005-09-11	Hoffmann La Roche	Benzodiazepine derivatives as GABA A receptor modulators

2002
- 2002-04-09 US US10/118,584 patent/US6686352B2/en not_active Expired - Fee Related
- 2002-05-08 HU HU0400743A patent/HUP0400743A3/hu unknown
- 2002-05-08 NZ NZ529097A patent/NZ529097A/en unknown
- 2002-05-08 WO PCT/EP2002/005121 patent/WO2002094834A1/en active IP Right Grant
- 2002-05-08 CZ CZ20033355A patent/CZ20033355A3/cs unknown
- 2002-05-08 PT PT02771640T patent/PT1399448E/pt unknown
- 2002-05-08 BR BR0209859-8A patent/BR0209859A/pt not_active IP Right Cessation
- 2002-05-08 YU YU90003A patent/YU90003A/sh unknown
- 2002-05-08 IL IL15857202A patent/IL158572A0/xx unknown
- 2002-05-08 MX MXPA03010529A patent/MXPA03010529A/es active IP Right Grant
- 2002-05-08 AU AU2002338898A patent/AU2002338898B2/en not_active Ceased
- 2002-05-08 ES ES02771640T patent/ES2232778T3/es not_active Expired - Lifetime
- 2002-05-08 CA CA002446903A patent/CA2446903C/en not_active Expired - Fee Related
- 2002-05-08 RU RU2003136078/04A patent/RU2287531C2/ru not_active IP Right Cessation
- 2002-05-08 PL PL02366846A patent/PL366846A1/xx not_active Application Discontinuation
- 2002-05-08 SK SK1525-2003A patent/SK15252003A3/sk unknown
- 2002-05-08 DK DK02771640T patent/DK1399448T3/da active
- 2002-05-08 KR KR10-2003-7015036A patent/KR100533406B1/ko not_active IP Right Cessation
- 2002-05-08 AT AT02771640T patent/ATE283857T1/de not_active IP Right Cessation
- 2002-05-08 JP JP2002591507A patent/JP4068466B2/ja not_active Expired - Fee Related
- 2002-05-08 EP EP02771640A patent/EP1399448B1/de not_active Expired - Lifetime
- 2002-05-08 DE DE60202147T patent/DE60202147T2/de not_active Expired - Lifetime
- 2002-05-08 CN CNB028101774A patent/CN1230436C/zh not_active Expired - Fee Related
- 2002-05-08 SI SI200230055T patent/SI1399448T1/xx unknown
- 2002-05-14 JO JO200243A patent/JO2297B1/en active
- 2002-05-15 TW TW091110162A patent/TWI251489B/zh not_active IP Right Cessation
- 2002-05-15 PA PA20028545201A patent/PA8545201A1/es unknown
- 2002-05-16 AR ARP020101805A patent/AR033753A1/es not_active Application Discontinuation
- 2002-05-16 PE PE2002000413A patent/PE20030041A1/es not_active Application Discontinuation
- 2002-05-16 GT GT200200087A patent/GT200200087A/es unknown
- 2002-05-17 MY MYPI20021808A patent/MY127570A/en unknown
2003
- 2003-10-23 IL IL158572A patent/IL158572A/en not_active IP Right Cessation
- 2003-10-31 ZA ZA200308544A patent/ZA200308544B/en unknown
- 2003-11-04 HR HR20030890A patent/HRP20030890A2/xx not_active Application Discontinuation
- 2003-11-14 MA MA27398A patent/MA27024A1/fr unknown
- 2003-11-17 EC EC2003004851A patent/ECSP034851A/es unknown
- 2003-11-17 NO NO20035104A patent/NO20035104L/no not_active Application Discontinuation
- 2003-11-18 BG BG108369A patent/BG108369A/bg unknown
2004
- 2004-12-01 HK HK04109492A patent/HK1066544A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
SI1399448T1 (en)	2005-02-28
BG108369A (bg)	2005-01-31
PA8545201A1 (es)	2003-02-28
YU90003A (sh)	2006-08-17
JP4068466B2 (ja)	2008-03-26
ZA200308544B (en)	2005-01-31
KR100533406B1 (ko)	2005-12-02
PT1399448E (pt)	2005-03-31
MA27024A1 (fr)	2004-12-20
NO20035104D0 (no)	2003-11-17
AU2002338898B2 (en)	2007-03-15
US20030055042A1 (en)	2003-03-20
CZ20033355A3 (en)	2004-07-14
DK1399448T3 (da)	2005-04-11
GT200200087A (es)	2003-06-19
AR033753A1 (es)	2004-01-07
BR0209859A (pt)	2004-06-15
IL158572A0 (en)	2004-05-12
US6686352B2 (en)	2004-02-03
CA2446903C (en)	2008-12-30
CN1509289A (zh)	2004-06-30
EP1399448A1 (de)	2004-03-24
NO20035104L (no)	2003-11-17
TWI251489B (en)	2006-03-21
IL158572A (en)	2010-02-17
HUP0400743A2 (hu)	2004-07-28
PL366846A1 (en)	2005-02-07
HRP20030890A2 (en)	2005-08-31
AU2002338898B8 (en)	2002-12-03
MXPA03010529A (es)	2004-03-02
NZ529097A (en)	2005-04-29
SK15252003A3 (sk)	2004-08-03
MY127570A (en)	2006-12-29
ATE283857T1 (de)	2004-12-15
ES2232778T3 (es)	2005-06-01
EP1399448B1 (de)	2004-12-01
PE20030041A1 (es)	2003-02-07
CA2446903A1 (en)	2002-11-28
HK1066544A1 (en)	2005-03-24
DE60202147T2 (de)	2005-12-01
JP2004531563A (ja)	2004-10-14
WO2002094834A1 (en)	2002-11-28
KR20040002975A (ko)	2004-01-07
HUP0400743A3 (en)	2007-09-28
RU2003136078A (ru)	2005-05-27
JO2297B1 (en)	2005-09-12
RU2287531C2 (ru)	2006-11-20
CN1230436C (zh)	2005-12-07
ECSP034851A (es)	2003-12-24

Publication	Publication Date	Title
DE60202147D1 (de)	2005-01-05	Imidazo(1,5-a!pyrimido)5,4-d!benz azepinderivate als gaba-a-rezeptormodulatoren
ATE251623T1 (de)	2003-10-15	Imidazo(1,2-a)pyridin- und pyrazolo(2,3- a)pyridinderivate
ATE284404T1 (de)	2004-12-15	Pyrazolo(4,3-d)pyrimidinderivate
DK1699795T3 (da)	2007-09-10	Substituerede 8'-pyri(mi)dinyldihydrospiro[cycloalkylamin]-pyrimido[1,2-a]pyrimidin-6-onderivater
DE60103776D1 (de)	2004-07-15	Benzodiazepinderivate als gaba-a-rezeptormodulatoren
NO20022738L (no)	2002-06-07	Pyrrolo(2,3-d)pyrimidinforbindelser
PT996621E (pt)	2004-02-27	Derivados da triazolo¬4,5-d\|pirimidina como agentes anti-tromboticos
IL160878A0 (en)	2004-08-31	Imidazo (4,3-e)-1,2,4-triazolo (1,5-c) pyrimidines as adenosine a2a receptor antagonists
NO20041142L (no)	2004-06-21	Subsitituerte 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-A]pyrimidin-4-on og 7-pyrimidinyl-2,3-dihydroimidazo[1,2-A]pyrimidin-5(1H)on-derivater for neurodegenerative lidelser
ATE269333T1 (de)	2004-07-15	2-pyridinyl-6,7,8,9-tetrahydropyrimido(1,2- a)pyrimidin-4-on- und 7-pyridinyl-2,3- dihydroimidazo(1,2-a)pyrimidin-5 1honderivate
DK1430057T3 (da)	2006-01-16	Substituerede 2-pyridinyl-6,7,8, 9-tetrahydropyrimido [1,2-a] pyrimidin-4-on- og 7-pyridinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)onderivater
EE200100377A (et)	2002-10-15	Imidaso[1,5-a]-pürido[3,2-e]-pürasinoonide kasutamine arstimitena
DK1210349T3 (da)	2003-05-19	Pyrazolo[4,3-d]pyrimidiner
EE200400078A (et)	2004-06-15	Tritsüklilisi 5,6-dihüdro-9H-pürasolo[3,4-c]-1,2,4-triasolo[4,3-alfa]püridiine sisaldavad inhalatsioonikompositsioonid
PL370565A1 (en)	2005-05-30	5-methoxy-8-aryl-[1,2,4] triazolo [1,5-a] pyridine derivatives as adenosine receptor antagonists
DK1678182T3 (da)	2007-06-04	Fremgangsmåde til fremstilling af substituerede 5-amino-pyrazolo[4,3-E]-1,2,4-triazolo-[1,5-C]pyrimidiner
DE69902606D1 (de)	2002-10-02	Spiro(piperidin-4,1'-pyrrolo(3,4-c)pyrrole)
PT1326866E (pt)	2005-08-31	3,4-di-hidropirido[1,2-a]pirimidinas substituidas
ATE294180T1 (de)	2005-05-15	Substituierte 3,4-dihydro-pyrimido (1,2- a)pyrimidine und 3,4-dihydropyrazino (1,2- a)pyrimidine
EE200100700A (et)	2003-04-15	Asendatud [1,4]diasepino[6,7,1-hi]indool-4-oonidevalmistamismeetod
DK1330457T3 (da)	2005-02-28	Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoler som 5HT2C-antagonister
PL366807A1 (en)	2005-10-03	New derivatives of 1h-pyrazolo[4,3-e]-1,2,4-triazolo[3,4-b][1,2,4]- triazine system
DK1326866T3 (da)	2005-08-01	Substituerede 3,4-dihydro-pyrido[1,2-a]pyrimidiner

Legal Events

Date	Code	Title	Description
2006-01-05	8364	No opposition during term of opposition