PE20071182A1 - Derivados de bencimidazol sustituidos con cromano como inhibidores de la bomba de acido - Google Patents
Derivados de bencimidazol sustituidos con cromano como inhibidores de la bomba de acidoInfo
- Publication number
- PE20071182A1 PE20071182A1 PE2006001625A PE2006001625A PE20071182A1 PE 20071182 A1 PE20071182 A1 PE 20071182A1 PE 2006001625 A PE2006001625 A PE 2006001625A PE 2006001625 A PE2006001625 A PE 2006001625A PE 20071182 A1 PE20071182 A1 PE 20071182A1
- Authority
- PE
- Peru
- Prior art keywords
- chromen
- dihydro
- oxy
- hydrogen
- hydroxy
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical group C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 title 1
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title 1
- VZWXIQHBIQLMPN-UHFFFAOYSA-N chromane Chemical group C1=CC=C2CCCOC2=C1 VZWXIQHBIQLMPN-UHFFFAOYSA-N 0.000 title 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 BENZIMIDAZOLE DERIVATIVE COMPOUND Chemical class 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- DBTDEFJAFBUGPP-UHFFFAOYSA-N Methanethial Chemical compound S=C DBTDEFJAFBUGPP-UHFFFAOYSA-N 0.000 abstract 1
- 208000008469 Peptic Ulcer Diseases 0.000 abstract 1
- 208000007107 Stomach Ulcer Diseases 0.000 abstract 1
- 101100073357 Streptomyces halstedii sch2 gene Proteins 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 201000005917 gastric ulcer Diseases 0.000 abstract 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 208000011906 peptic ulcer disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Nutrition Science (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
REFERIDA A UN COMPUESTO DERIVADO DE BENCIMIDAZOL DE FORMULA (I), DONDE A-B ES OCH2, SCH2, CH2-O- o CH2S; X ES OXIGENO O NH; R1 ES ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO CON 1 O 2 SUSTITUYENTES ELEGIDOS DE HIDROXI Y ALCOXI C1-C6; R2 Y R3 SON HIDROGENO, ALQUILO C1-C6, CICLOALQUILO C3-C7, ENTRE OTROS; R4, R5, R6 Y R7 SON HIDROGENO, HALOGENO, HIDROXI, ALQUILO C1-C6, ENTRE OTROS; R8 ES HIDROGENO, HIDROXI O ALCOXI C1-C6. SON COMPUESTOS PREFERIDOS: 4-[(5,7-DIFLUORO-3,4-DIHIDRO-2H-CROMEN-4-IL)OXI]-N,N,2-TRIMETIL-1H-BENCIMIDAZOL-6-CARBOXAMIDA, 4-[(5,7-DIFLUORO-3,4-DIHIDRO-2H-CROMEN-4-IL)OXI]-2-METIL-6-(PIRROLIDIN-1-ILCARBONIL)-1H-BENCIMIDAZOL, 4-[(5-FLUORO-3,4-DIHIDRO-2H-CROMEN-4-IL)OXI]-N,N,2-TRIMETIL-1H-BENCIMIDAZOL-6-CARBOXAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS TIENEN ACTIVIDAD INHIBIDORA DE LA BOMBA DE ACIDO Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES GASTROINTESTINALES, GASTROESOFAGICAS, DE REFLUJO GASTROESOFAGICO, ULCERA PEPTICA, ULCERA GASTRICA, GASTRITIS, DISPEPSIA, CANCER, ENTRE OTRAS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75218105P | 2005-12-19 | 2005-12-19 | |
| US80294406P | 2006-05-23 | 2006-05-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20071182A1 true PE20071182A1 (es) | 2008-02-07 |
Family
ID=37912450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006001625A PE20071182A1 (es) | 2005-12-19 | 2006-12-18 | Derivados de bencimidazol sustituidos con cromano como inhibidores de la bomba de acido |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7723321B2 (es) |
| EP (1) | EP1963311B1 (es) |
| JP (1) | JP4481344B2 (es) |
| KR (1) | KR101088247B1 (es) |
| CN (2) | CN102321077A (es) |
| AR (1) | AR058120A1 (es) |
| AT (1) | ATE471319T1 (es) |
| BR (2) | BRPI0620081B8 (es) |
| CA (1) | CA2631880C (es) |
| DE (1) | DE602006014996D1 (es) |
| DO (1) | DOP2006000285A (es) |
| ES (1) | ES2345726T3 (es) |
| GT (1) | GT200600514A (es) |
| HK (1) | HK1125368A1 (es) |
| NL (1) | NL2000371C2 (es) |
| PE (1) | PE20071182A1 (es) |
| TW (1) | TW200732326A (es) |
| UY (1) | UY30043A1 (es) |
| WO (1) | WO2007072146A1 (es) |
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| JP5492770B2 (ja) * | 2007-06-26 | 2014-05-14 | サノフイ | ベンゾイミダゾール及びアザベンゾイミダゾールの位置選択的銅触媒合成 |
| BRPI1013288A2 (pt) | 2009-07-09 | 2016-03-29 | Raqualia Pharma Inc | uso de um composto, método de composição farmacêutica para o tratamento de doenças em que a motilidade gastrointestinal anormal está envolvida, kit e embalagem comercial que compreende uma composição farmacêutica contendo o composto |
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| KR102084185B1 (ko) | 2013-08-29 | 2020-03-04 | 주식회사 대웅제약 | 테트라히드로사이클로펜타피롤 유도체 및 이의 제조방법 |
| KR102129842B1 (ko) * | 2013-10-02 | 2020-07-06 | 주식회사 대웅제약 | 술포닐인돌 유도체 및 이의 제조방법 |
| AU2014352875B2 (en) | 2013-11-22 | 2019-10-24 | CL BioSciences LLC | Gastrin antagonists (eg YF476, netazepide) for treatment and prevention of osteoporosis |
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| KR20240109898A (ko) | 2023-01-05 | 2024-07-12 | 위더스제약주식회사 | 무정형 테고프라잔 고체분산체 |
| KR20240118377A (ko) | 2023-01-27 | 2024-08-05 | 스마트바이오팜 주식회사 | 테고프라잔 중간체를 제조하는 방법 및 이에 사용되는 신규 중간체 |
| KR102638900B1 (ko) | 2023-01-27 | 2024-02-21 | 스마트바이오팜 주식회사 | 테고프라잔 중간체를 제조하는 방법 및 이에 사용되는 신규 중간체 |
| WO2024171128A1 (en) * | 2023-02-18 | 2024-08-22 | Lee Pharma Limited | Stable amorphous form of potassium-competitive acid blocker and process for the preparation thereof |
| KR20240131641A (ko) | 2023-02-24 | 2024-09-02 | 엠에프씨 주식회사 | 신규 테고프라잔의 염 결정형 및 이의 용매화물 결정형, 및 이들의 제조방법 |
| KR102715562B1 (ko) * | 2023-03-16 | 2024-10-11 | (주) 에프엔지리서치 | 테고프라잔의 신규 염 및 이의 제조 방법 |
| WO2024210689A1 (ko) * | 2023-04-07 | 2024-10-10 | 제이더블유중외제약 주식회사 | 벤즈이미다졸 유도체의 염 |
| KR20240171624A (ko) | 2023-05-31 | 2024-12-09 | 권대길 | 치환된 벤즈이미다졸의 결정형 및 이의 제조방법 |
| WO2025037242A1 (en) * | 2023-08-14 | 2025-02-20 | Ami Lifesciences Private Limited | Solid forms of tegoprazan and process thereof |
| KR102689851B1 (ko) | 2023-09-26 | 2024-07-30 | 스마트바이오팜 주식회사 | 테고프라잔 중간체를 제조하는 방법 및 이에 사용되는 신규 중간체 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8604566D0 (sv) * | 1986-10-27 | 1986-10-27 | Haessle Ab | Novel compunds |
| US5444775A (en) | 1993-11-09 | 1995-08-22 | Tobish; John J. | Telephone key selection aid |
| SE9602286D0 (sv) * | 1996-06-10 | 1996-06-10 | Astra Ab | New compounds |
| GB9914022D0 (en) | 1999-06-17 | 1999-08-18 | Zeneca Ltd | Chemical compounds |
| AR043063A1 (es) * | 2002-12-13 | 2005-07-13 | Altana Pharma Ag | Bencimidazoles 6-sustituidos y su uso como inhibidores de secreciones gastricas |
| AR049168A1 (es) * | 2004-05-18 | 2006-07-05 | Altana Pharma Ag | Derivados de benzimidazol |
| DE602006009105D1 (de) * | 2005-06-14 | 2009-10-22 | Raqualia Pharma Inc | Chroman-substituierte benzimidazolderivate als säurepumpenantagonisten |
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2006
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- 2006-12-06 CN CN2011101399640A patent/CN102321077A/zh active Pending
- 2006-12-06 CA CA2631880A patent/CA2631880C/en active Active
- 2006-12-06 CN CN2006800479255A patent/CN101341149B/zh active Active
- 2006-12-06 ES ES06831708T patent/ES2345726T3/es active Active
- 2006-12-06 KR KR1020087017466A patent/KR101088247B1/ko active Active
- 2006-12-06 DE DE602006014996T patent/DE602006014996D1/de active Active
- 2006-12-06 BR BRPI0620081A patent/BRPI0620081B8/pt active IP Right Grant
- 2006-12-06 AT AT06831708T patent/ATE471319T1/de not_active IP Right Cessation
- 2006-12-06 BR BR122020004679-1A patent/BR122020004679B1/pt not_active IP Right Cessation
- 2006-12-06 JP JP2008546663A patent/JP4481344B2/ja active Active
- 2006-12-06 WO PCT/IB2006/003605 patent/WO2007072146A1/en active Application Filing
- 2006-12-13 NL NL2000371A patent/NL2000371C2/nl not_active IP Right Cessation
- 2006-12-18 GT GT200600514A patent/GT200600514A/es unknown
- 2006-12-18 PE PE2006001625A patent/PE20071182A1/es not_active Application Discontinuation
- 2006-12-18 DO DO2006000285A patent/DOP2006000285A/es unknown
- 2006-12-18 TW TW095147456A patent/TW200732326A/zh unknown
- 2006-12-19 AR ARP060105611A patent/AR058120A1/es unknown
- 2006-12-19 US US11/612,583 patent/US7723321B2/en active Active
- 2006-12-19 UY UY30043A patent/UY30043A1/es not_active Application Discontinuation
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Also Published As
| Publication number | Publication date |
|---|---|
| ES2345726T3 (es) | 2010-09-30 |
| JP4481344B2 (ja) | 2010-06-16 |
| CN101341149B (zh) | 2011-06-08 |
| BR122020004679B1 (pt) | 2021-09-21 |
| HK1125368A1 (en) | 2009-08-07 |
| WO2007072146A1 (en) | 2007-06-28 |
| ATE471319T1 (de) | 2010-07-15 |
| CN102321077A (zh) | 2012-01-18 |
| EP1963311B1 (en) | 2010-06-16 |
| NL2000371C2 (nl) | 2007-09-06 |
| CN101341149A (zh) | 2009-01-07 |
| NL2000371A1 (nl) | 2007-06-20 |
| JP2009520017A (ja) | 2009-05-21 |
| CA2631880A1 (en) | 2007-06-28 |
| BRPI0620081B8 (pt) | 2021-05-25 |
| DOP2006000285A (es) | 2007-07-31 |
| US20070142448A1 (en) | 2007-06-21 |
| US7723321B2 (en) | 2010-05-25 |
| AR058120A1 (es) | 2008-01-23 |
| TW200732326A (en) | 2007-09-01 |
| KR20080080195A (ko) | 2008-09-02 |
| CA2631880C (en) | 2011-03-29 |
| BRPI0620081A2 (pt) | 2011-11-01 |
| EP1963311A1 (en) | 2008-09-03 |
| GT200600514A (es) | 2007-07-17 |
| BRPI0620081B1 (pt) | 2020-10-20 |
| DE602006014996D1 (de) | 2010-07-29 |
| UY30043A1 (es) | 2007-07-31 |
| KR101088247B1 (ko) | 2011-11-30 |
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