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EA201291356A1 - Пиперидиноновые производные как ингибиторы mdm2 для лечения рака - Google Patents

Пиперидиноновые производные как ингибиторы mdm2 для лечения рака

Info

Publication number
EA201291356A1
EA201291356A1 EA201291356A EA201291356A EA201291356A1 EA 201291356 A1 EA201291356 A1 EA 201291356A1 EA 201291356 A EA201291356 A EA 201291356A EA 201291356 A EA201291356 A EA 201291356A EA 201291356 A1 EA201291356 A1 EA 201291356A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cancer treatment
piperidine derivatives
mdm2 inhibitors
present
compounds
Prior art date
Application number
EA201291356A
Other languages
English (en)
Other versions
EA023004B1 (ru
Inventor
Майкл Дэвид Бартбергер
Ана Гонсалес Буэнростро
Хилари Плэйк Бек
Сяоци Чэнь
Ричард Виктор Коннорс
Джеффри Дейгнан
Джейсон Дукветт
Джон Экстерович
Бенджамин Фишер
Брайан Мэттью Фокс
Цзяшэн Фу
Цзыцэ Фу
Феликс Гонсалес Лопес де Турисо
мл. Майкл Уилльям Гриббл
Дарин Джеймс Гастин
Джули Энн Хит
Синь Хуан
Сяньюнь Цзяо
Майкл Джонсон
Франк Кайзер
Дэвид Джон Копески
Суцзен Лай
Ихун Ли
Чжихун Ли
Цзивэнь Лю
Джонатан Данте Лоу
Брайан Стюарт Лукас
Чжихуа Ма
Лоуренс Макги
Джоэл Макинтош
Дастин Макминн
Хулио Сезар Медина
Джеффри Томас Михалик
Стивен Ховард Олсон
Йосуп Рью
Филип Марли Ровето
Дацин Сунь
Сяодун Ван
Инцай Ван
Сюэлэй Янь
Мин Юй
Цзян Чжу
Original Assignee
Эмджен Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44504412&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201291356(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эмджен Инк. filed Critical Эмджен Инк.
Publication of EA201291356A1 publication Critical patent/EA201291356A1/ru
Publication of EA023004B1 publication Critical patent/EA023004B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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Abstract

В настоящем изобретении представлены соединения-ингибиторы MDM2 формулы (I)где переменные определены выше, и эти соединения являются полезными в качестве терапевтических средств, в частности, для лечения раковых заболеваний. Настоящее изобретение также относится к фармацевтическим композициям, содержащим ингибитор MDM2.
EA201291356A 2010-06-04 2011-06-03 Пиперидиноновые производные как ингибиторы mdm2, фармацевтическая композиция, содержащая их, и способ лечения рака EA023004B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US35182710P 2010-06-04 2010-06-04
US35232210P 2010-06-07 2010-06-07
US201161452578P 2011-03-14 2011-03-14
PCT/US2011/039184 WO2011153509A1 (en) 2010-06-04 2011-06-03 Piperidinone derivatives as mdm2 inhibitors for the treatment of cancer

Publications (2)

Publication Number Publication Date
EA201291356A1 true EA201291356A1 (ru) 2013-06-28
EA023004B1 EA023004B1 (ru) 2016-04-29

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EA201291356A EA023004B1 (ru) 2010-06-04 2011-06-03 Пиперидиноновые производные как ингибиторы mdm2, фармацевтическая композиция, содержащая их, и способ лечения рака

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US (9) US8569341B2 (ru)
EP (4) EP2927213B1 (ru)
JP (3) JP5420797B2 (ru)
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